In the context of cancer treatment, surgery, chemotherapy and radiotherapy are among the main therapies used. However, emerging therapies are gaining prominence. The use of immunotherapy and targeted therapy, even tho...
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Introduction and Objectives Hepatitis E is an infection caused by the E virus (HEV) with the fecal-oral transmission. The spectrum of the disease varies from acute form to chronic evolution. There are few studies in t...
Introduction and Objectives Hepatitis E is an infection caused by the E virus (HEV) with the fecal-oral transmission. The spectrum of the disease varies from acute form to chronic evolution. There are few studies in the rural region of Bahia State. This study aimed to study the seroprevalence of hepatitis E in a city in a rural region in Brazil. Materials and Methods Held in May 2022 at family health clinics (PSFs) in the city of Serrinha-Bahia State, with 80,000 inhabitants and 184.6 km from Salvador, capital city. Participants who agreed to integrate into the study signed the Free and Informed Consent Term, collected blood samples and answered the questionnaire. The samples were stored at -20°C until the moment of use; those that needed to be retested for IgM were transported on dry ice and frozen at -80°C. IgG and IgM anti-HEV diagnostic kits (mikrogen and Diapro) approved by ANVISA of MS in Brazil were used. Medical-educational activities were carried out in the units on the prevention of viral hepatitis and health Results Of a sample of 300 volunteers, actually, 150 blood samples were analyzed, the prevalence of anti-HEV IgM and IgG was 2.66%, and anti-HEV IgG alone was 8.6%. Most were women, 75.3%, and the average age was 43 years (18 to 78 years). Median liver enzymes in HEV-positive patients were AST (27.5 IU/L), ALT (21 IU/L), and GGT (58.5 IU/L). Among the samples, 81% of the residences were in rural areas, 90.5% did not have a sewage system, 94.6% had running water, and 39.5% worked or worked with animal husbandry. Only 1.4% experienced flooding. The majority, 95.4%, consume pork and/or derivatives and 19.7% consume hunting meat. Conclusions A seroprevalence of 8.6% was found, higher than the result in a parallel study of our team in Salvador City (1.8%) and associated with a lack of basic sanitation, especially in rural areas.
Purpose: To verify evidence of subclinical alterations through self-reported participation restrictions in normal hearing individuals and congenital hypothyroidism ***: An analytical, quantitative, cross-sectional exp...
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Purpose: To verify evidence of subclinical alterations through self-reported participation restrictions in normal hearing individuals and congenital hypothyroidism ***: An analytical, quantitative, cross-sectional exploratory study with a 1:1 ratio, consisting of a convenience sample of 86 normal hearing individuals with(n = 42) and without(n = 44) congenital hypothyroidism diagnosis. All participants underwent tonal and speech audiometry, immitance and distortion product otoacoustic emissions. The researchers excluded people with hearing loss, genetic syndromes and metabolic diseases. The instrument used for evaluate of self-reported participation restrictions was the HHIE-adapted questionnaire, composed of 25 questions, 12 of which were social domain and 13 emotional domain. Student's ttest and chi-square test were used for statistical analysis at a significance level of 5%.Results: There was a significant(p < 0.001) self-reported participation restrictions in CH(61.9%), with a greater relevance for the social domain(p = 0.002). There was a greater frequency of mild/moderate(40.5%)and higher prevalence of association with clinical factors and adherence to ***: The findings indicate that self-reported participation restrictions in normal hearing individuals with congenital hypothyroidism was more significant than in the non-exposed group, suggesting evidence of subclinical auditory abnormalities in this population.
Leprosy is an infectious disease caused by Mycobacterium leprae, transmitted from person to person through contact among susceptible untreated patients. It presents a broad clinical spectrum which is related to the h...
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Leprosy is an infectious disease caused by Mycobacterium leprae, transmitted from person to person through contact among susceptible untreated patients. It presents a broad clinical spectrum which is related to the host’s ability to mount a specific immune response. The lesions caused by the proliferation of Mycobacterium leprae (M. leprae) were significantly reduced in recent years with the early detection of new cases. Because they are less evident and/or study, maxillofacial injuries and the oral mucosa may reveal important details about the transmissibility and immunopathogenesis of leprosy. This article was based on a literature to verify an interrelation between oral manifestations in virchowian patients and immuno-pathological factors. Association between the infection of oral mucosa and some pathological findings as well as the participation of the local immune response in protection against the disease are research topics still not fully exploited.
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