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Human genome meeting 2016 : Houston, TX, USA. 28 February - 2 March 2016

Human genomics 2016年第1期10 Suppl 1卷 12页

作者： A. K. Srivastava Y. Wang R. Huang C. Skinner T. Thompson L. Pollard T. Wood F. Luo R. Stevenson R. Polimanti J. Gelernter X. Lin I. Y. Lim Y. Wu A. L. Teh L. Chen I. M. Aris S. E. Soh M. T. Tint J. L. MacIsaac F. Yap K. Kwek S. M. Saw M. S. Kobor M. J. Meaney K. M. Godfrey Y. S. Chong J. D. Holbrook Y. S. Lee P. D. Gluckman N. Karnani A. Kapoor D. Lee A. Chakravarti C. Maercker F. Graf M. Boutros G. Stamoulis F. Santoni P. Makrythanasis A. Letourneau M. Guipponi N. Panousis M. Garieri P. Ribaux E. Falconnet C. Borel S. E. Antonarakis S. Kumar J. Curran J. Blangero S. Chatterjee J. Akiyama D. Auer C. Berrios L. Pennacchio T. R. Donti G. Cappuccio M. Miller P. Atwal A. Kennedy A. Cardon C. Bacino L. Emrick J. Hertecant F. Baumer B. Porter M. Bainbridge P. Bonnen B. Graham R. Sutton Q. Sun S. Elsea Z. Hu P. Wang Y. Zhu J. Zhao M. Xiong David A. Bennett A. Hidalgo-Miranda S. Romero-Cordoba S. Rodriguez-Cuevas R. Rebollar-Vega E. Tagliabue M. Iorio E. D’Ippolito S. Baroni B. Kaczkowski Y. Tanaka H. Kawaji A. Sandelin R. Andersson M. Itoh T. Lassmann Y. Hayashizaki P. Carninci A. R. R. Forrest C. A. Semple E. A. Rosenthal B. Shirts L. Amendola C. Gallego M. Horike-Pyne A. Burt P. Robertson P. Beyers C. Nefcy D. Veenstra F. Hisama R. Bennett M. Dorschner D. Nickerson J. Smith K. Patterson D. Crosslin R. Nassir N. Zubair T. Harrison U. Peters G. Jarvik F. Menghi K. Inaki X. Woo P. Kumar K. Grzeda A. Malhotra H. Kim D. Ucar P. Shreckengast K. Karuturi J. Keck J. Chuang E. T. Liu B. Ji A. Tyler G. Ananda G. Carter H. Nikbakht M. Montagne M. Zeinieh A. Harutyunyan M. Mcconechy N. Jabado P. Lavigne J. Majewski J. B. Goldstein M. Overman G. Varadhachary R. Shroff R. Wolff M. Javle A. Futreal D. Fogelman L. Bravo W. Fajardo H. Gomez C. Castaneda C. Rolfo J. A. Pinto K. C. Akdemir L. Chin S. Patterson C. Statz S. Mockus S. N. Nikolaev X. I. Bonilla L. Parmentier B. King F. Bezrukov G. Kaya V. Zoete V. Seplyarskiy H. Sharpe T. McKee K. Popadin N. Basset-Seguin R. Ben Chaabene M. Andrianova C. Verdan K. Grosdemange O. Sumara M. E JCSRI Greenwood Genetic Center Greenwood USA School of Computing Clemson University Clemson USA Biochemical Genetics Laboratory Greenwood Genetic Center Greenwood USA Department Psychiatry Yale Sch Med and VA CT Healthcare Center West Haven USA Department Genetics Yale Sch Med and VA CT Healthcare Center West Haven USA Department Neurobiology Yale Sch Med and VA CT Healthcare Center West Haven USA Singapore Institute for Clinical Sciences Singapore Singapore National University of Singapore Singapore Singapore University of British Columbia Vancouver Canada KK Women’s and Children’s Hospital Singapore Singapore University of Southampton and University Hospital Southampton NHS Foundation Trust Southampton UK University of Auckland Auckland New Zealand McKusick-Nathans Institute of Genetic Medicine Johns Hopkins University School of Medicine Baltimore USA Esslingen University of Applied Sciences Esslingen Germany German Cancer Research Center Heidelberg Germany Department of Genetic Medicine and Development University of Geneva Medical School Geneva Switzerland Geneva University Hospitals-HUG Service of Genetic Medicine Geneva Switzerland GE3 Institute of Genetics and Genomics of Geneva University of Geneva Medical School Geneva Switzerland South Texas Diabetes and Obesity Institute School of Medicine University of Texas Rio-Grande Valley Edinburg USA South Texas Diabetes and Obesity Institute School of Medicine University of Texas Rio-Grande Valley Brownsville USA Institute of Genetic Medicine Johns Hopkins University Baltimore USA Genomics Division Lawrence Berkeley National Laboratory Berkeley USA Molecular and Human Genetics Baylor College of Medicine Houston USA Department of Translational Medical Sciences Federico II University Naples Italy Metabolon Inc Durham USA Section of Pediatric Neurology and Neuroscience Baylor College of Medicine Houston USA Tawam Hospital Abu Dhabi United Arab Emirates Stanford Medical School Stanford USA Sch

O1 The metabolomics approach to autism: identification of biomarkers for early detection of autism spectrum disorder A. K. Srivastava, Y. Wang, R. Huang, C. Skinner, T. Thompson, L. Pollard, T. Wood, F. Luo, R. Stevenson O2 Phenome-wide association study for smoking- and drinking-associated genes in 26,394 American women with African, Asian, European, and Hispanic descents R. Polimanti, J. Gelernter O3 Effects of prenatal environment, genotype and DNA methylation on birth weight and subsequent postnatal outcomes: findings from GUSTO, an Asian birth cohort X. Lin, I. Y. Lim, Y. Wu, A. L. Teh, L. Chen, I. M. Aris, S. E. Soh, M. T. Tint, J. L. MacIsaac, F. Yap, K. Kwek, S. M. Saw, M. S. Kobor, M. J. Meaney, K. M. Godfrey, Y. S. Chong, J. D. Holbrook, Y. S. Lee, P. D. Gluckman, N. Karnani, GUSTO study group O4 High-throughput identification of specific qt interval modulating enhancers at the SCN5A locus A. Kapoor, D. Lee, A. Chakravarti O5 Identification of extracellular matrix components inducing cancer cell migration in the supernatant of cultivated mesenchymal stem cells C. Maercker, F. Graf, M. Boutros O6 Single cell allele specific expression (ASE) IN T21 and common trisomies: a novel approach to understand DOWN syndrome and other aneuploidies G. Stamoulis, F. Santoni, P. Makrythanasis, A. Letourneau, M. Guipponi, N. Panousis, M. Garieri, P. Ribaux, E. Falconnet, C. Borel, S. E. Antonarakis O7 Role of microRNA in LCL to IPSC reprogramming S. Kumar, J. Curran, J. Blangero O8 Multiple enhancer variants disrupt gene regulatory network in Hirschsprung disease S. Chatterjee, A. Kapoor, J. Akiyama, D. Auer, C. Berrios, L. Pennacchio, A. Chakravarti O9 Metabolomic profiling for the diagnosis of neurometabolic disorders T. R. Donti, G. Cappuccio, M. Miller, P. Atwal, A. Kennedy, A. Cardon, C. Bacino, L. Emrick, J. Hertecant, F. Baumer, B. Porter, M. Bainbridge, P. Bonnen, B. Graham, R. Sutton, Q. Sun, S. Elsea O10 A novel causal methylation network approach to Alzheimer’s

关键词： Pulmonary Arterial Hypertension Oral Squamous Cell Carcinoma Deep Neural Network Autosomal Recessive Polycystic Kidney Disease Whole Genome Bisulfite Sequencing

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Adaptation and Nucleation of Anaerobic Granules under Synthetic and Natural Polymers

Adaptation and Nucleation of Anaerobic Granules under Synthe...

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2012 2nd International Conference on Environment and Industrial Innovation（ICEII 2012）

作者： Nasrul Hudayah Benjaphon Suraraksa Pawinee Chaiprasert Environmental Technology Program The Joint Graduate School of Energy and Environment King Mongkut's University of Technology Thonburi Bangkok Thailand Excellent Center of Waste Utilization and Management National Center of Genetic Engineering and Biotechnology (BIOTEC) Bangkok Thailand Division of Biotechnology School of Bioresources and Technology King Mongkut’s University of Technology Thonburi Bangkok Thailand

Nucleation or granule nuclei formation is an important step in the formation of anaerobic granules. This research was aimed to investigate the formation and time for granule nuclei under the addition of synthetic and natural cationic polymers. In addition, the increase activity of synthroph microorgansm in granule nuclei by adaptation with volatile fatty acid (VFA) was also studied. Three UASB reactors were used namely R1, R2 and R3 as control, addition of synthetic and natural polymers, respectively. Three reactors were operated under identical conditions. VFA was used as main substrate to adapt seed sludge and built synthroph microbial nuclei. Based on size distribution, nucleation was achieved at day 69 in R2 with average diameter size about 126 μm, size distribution 50.7% of >100 μm-aggregates and SVI 42 ml.g -1 SS. The activities of specific non-methanogens and methanogen in reactors added polymers (R2 and R3) were lower than control reactor. However, adaptation of specific microorganism succeed due to their activities from methanogens, propionate- and butyrate- degrading microorganism were higher than initial activities. R2 showed as better cationic polymer compared to chitosan for shortening nucleation phase.

关键词： Cationic polymer, synthroph, nucleation, aggregates, anaerobic granules

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Water scarcity and drought in WANA countries

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Procedia Engineering 2012年 33卷 14-29页

作者： Jauad El Kharraz Alaa El-Sadek Noreddine Ghaffour Eric Mino Euro-Mediterranean Information System on know-how in the Water sector (EMWIS) BP 23 Sophia Antipolis 06901 France Water Resources Management Program College of Graduate Studies Arabian Gulf University Kingdom of Bahrain Water Desalination and Reuse Center King Abdullah University of Science and Technology (KAUST) KSA

Water Security was a central theme of WANA Forum 2010, where regional experts warned that the wars of the 21st century will be fought over water. Climate change will only exacerbate problems in a region already stressed by lack of water, food and political and social unrest. Across the Arc of Crisis, from Somalia, Sudan and Egypt in Africa to Yemen, Iraq, Pakistan, and Afghanistan in West Asia, water scarcity in the region has already lead to drought and famine, loss of livelihood, the spread of water-borne diseases, forced migrations and open conflict. Water scarcity is closely linked to food and health security, making better water management a key stepping stone for poverty reduction and economic growth. If nothing changes, most of the WANA countries will encounter, in less than a generation, serious problems in managing inland freshwater, the availability of which, in sufficient quantity and quality, may become, as it is already the case in several of these countries, a main challenge for economic and social development. Wastage and pollution will then be such that « water stress » will affect, in a way or another, most of the populations of WANA countries and the poorest first of all. The effects of global warming will increase current trends. On the other hand, water scarcity in the WANA region is an issue of growing concern. With heavy demand from agriculture, growing populations and virtually no remaining untapped water sources, the need to establish water-management strategies in the region is of vital importance. WANA countries can be divided into three major agro-ecologies, each facing slightly different challenges. Rain-fed areas are dependent on a low and extremely variable rainfall, resulting in minimal yields, a problem exacerbated by frequent drought. Rainfall occurs in the form of intense and unpredictable storms, and as a result, the crusting soils are unable to absorb the moisture, which rapidly becomes lost through evaporation or runoff. Irrigate

关键词： water scarcity drought WANA region water demand water supply climate change

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Foresight scenario analysis of motor system of electric vehicle

Foresight scenario analysis of motor system of electric vehi...

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26th Electric Vehicle Symposium 2012, EVS 2012

作者： Shiue, Yih-Chearng Chen, Peng-Jen Lee, Chang-Franw Yu, Chih-Chiang Chen, Chih-Wei Department of Information Management National Central University No.300 Jhongda Rd. Jhongli City Taoyuan County 32001 Taiwan Graduate School of Design Doctoral Program National Yunlin University of Science and Technology No. 123 University Road Douliou Yunlin 64002 Taiwan Department of Industrial Design National Yunlin University of Science and Technology No. 123 University Road Douliou Yunlin 64002 Taiwan Department of Business Administration National Central University No.300 Jhongda Rd. Jhongli City Taoyuan County 32001 Taiwan

ISBN: (纸本)9781622764211

In order to describe the trend of motor system development of electric vehicle and to figure out the factors that would affect the external drives and the internal resources, the thesis uses scenario analysis method to be the basic framework, adding modified Delphi method to clarify time transition into five categories: changeless, changeable, disappeared, uncertain states and newborn. More precisely, the five factors is used to construct "Scenario Analysis of Markov Modified Delphi Method". The thesis focuses on motor system to do the Foresight analysis, using the transition concept of Markov Chain to clarify the key factors of uncertain states into motor system: brushless DC (BLDC) motor, surface permanent magnet synchronous motor and Switched Reluctance In-Wheel Motor. Moreover, the changeless concept of Markov Chain is used to be background, adding the key factors of changeable and uncertain states to clarify seven kinds of scenario portfolio: basic scenario, scenario assumption I, scenario assumption II, future scenario, breakthrough scenario I, breakthrough scenario II and challenge scenario. It could make the government, industries and related departments realize the development trend of key components about electric vehicle by the scenario descriptions. It can increase their willingness to invest in the related researches to achieve future image, also shape the usable engineering technique and integrated system concepts of electric vehicles in 2020 for public.

关键词： Electric vehicles

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Enhanced Heliothis virescens midgut regeneration and its role in resistance to Bacillus thuringiensis toxins

Enhanced Heliothis virescens midgut regeneration and its rol...

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第2届昆虫中肠生物学国际研讨会

作者： Ana(i)s S.Castagnola Omaththage P.Perera Cris Oppert Jerreme Jackson Fred Gould Juan Luis Jurat-Fuentes Department of Entomology and Plant Pathology University of TennesseeKnoxvilleTN 37996USA Southern Insect Management Research UnitUSDA-ARSStonevilleMS 38776USA Genome Science and Technology Graduate ProgramUniversity of TennesseeKnoxvilleTN 37996 Department of EntomologyNorth Carolina State UniversityRaleigh 27607USA

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How to gauge credit risk: An investigation based on data envelopment analysis and the Markov chain model

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Applied Financial Economics 2012年第11期22卷 887-897页

作者： Lu, Su-Lien Lee, Kuo-Jung Zou, Ming-Lun Graduate Institute of Finance National Pingtung University of Science and Technology Neipu Pingtung 912 1 Shuefu Road Taiwan Department of Commerce Automation and Management National Pingtung Institute of Commerce Pingtung Taiwan Master Program in Business Administration National United University Miao-Li Taiwan

Credit risk management is one of the most important issues in the financial services industry. This article proposes a formal methodology based on Data Envelopment Analysis (DEA) and the Markov chain model to assess the credit risk of major enterprises in Taiwan. The first step of this method involves the application of factor analysis to filter financial data according to dimensions and ratios. Second, we derive the credibility scores of domestic corporations with DEA. Third, regression analysis and discriminant analysis validate the results of DEA credibility scores. At this stage, we find that most firms in Taiwan need to improve their respective financial credibility. Fourth, we apply DEA credibility scores to the Markov chain model. Finally, we construct transition matrices to observe the transition process of the financial efficiency of the firms. The advantage of the proposed method is that it is simple to follow and implement, and its empirical results can enable banks and financial institutions to monitor their credit risk quite closely. By using this method, banks and other financial institutions will be able to make more efficient lending decisions and face the Basel Capital Accord in the future. © 2012 Copyright Taylor and Francis Group, LLC.

关键词： credit risk data envelopment analysis discriminant analysis factor analysis

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Delay impact analysis method for lost productivity in construction projects

Delay impact analysis method for lost productivity in constr...

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28th International Symposium on Automation and Robotics in Construction, ISARC 2011

作者： Yang, Jyh-Bin Huang, Kuei-Mei Lee, Chang-Hung Chen, Sheue-Meei Graduate Institute of Construction Engineering and Management National Central University Taiwan Program of Technology Management Chung Hua University Taiwan Department of Construction Management Chung Hua University Taiwan

Schedule delays commonly appear in construction projects and result in delay claim progressively. Several studies have proposed various schedule delay analysis methodologies. By using the as-planned and as-built schedules, most previous studies focus on the impact calculation of identified delay events on project duration. They consider the schedule variances between the as-planned and as-built schedules, but ignore to connect delay evidence to as-built schedule. Lost productivity, one essential delay cause, is usually experienced by a contractor while accomplishing its works less than planned rate of production. In a construction project, a contractor usually suffers certain damages by lost productivity caused by the owner or the third party, but the schedule impacts from the damages are not easily evaluated. How to calculate the schedule impacts by lost productivity plays a key role for solving a delay claim with lost productivity. This study tries to propose a delay analysis method for considering the schedule impact of lost productivity. With a simplified case study, the proposed method can be used as a tool to calculate the schedule impacts of schedule delays with lost productivity.

关键词： Contractors

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Case study of delay impact analysis of lost productivity in construction projects

Case study of delay impact analysis of lost productivity in ...

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28th International Symposium on Automation and Robotics in Construction, ISARC 2011

作者： Huang, Kuei-Mei Yang, Jyh-Bin Lee, Chang-Hung Ku, Ruei-Yu Program of Technology Management Chung Hua University Taiwan Graduate Institute of Construction Engineering and Management National Central University Taiwan Department of Construction Management Chung Hua University Taiwan

Schedule delays commonly appear in construction projects and result in delay claim progressively. Several studies have proposed various schedule delay analysis methodologies;however, most of the studies focus on the analysis of surface data (as-planned and as-built schedules), few of them on evaluating the effects of root causes, such as the problem of lost productivity. Lost productivity, one essential delay cause, is usually experienced by a contractor while accomplishing its works less than planned rate of production. For analyzing the situations of schedule impacts caused by lost productivity, this study discusses a case of delay analysis with lost productivity in Laiwan. Lhrough the study case, this study has proposed an approach to calculate schedule impact from lost productivity. Lhe study results will be a basis for developing a comprehensive delay analysis method considering lost productivity.

关键词： Productivity

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ESICM LIVES 2016: part two

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Intensive Care Medicine Experimental 2016年第1期4卷 205-404页

作者： S. Sivakumar F. S. Taccone K. A. Desai C. Lazaridis M. Skarzynski M. Sekhon W. Henderson D. Griesdale L. Chapple A. Deane L. Williams R. Strickland K. Lange D. Heyland M. Chapman M. J. Rowland P. Garry J. Westbrook R. Corkill C. A. Antoniades K. T. Pattinson G. Fatania A. J. Strong R. B. Myers C. M. Jermaine C. S. Robertson C. G. Rusin J. Hofmeijer L. Sondag M. C. Tjepkema-Cloostermans A. Beishuizen F. H. Bosch M. J. A. M. van Putten L. Carteron C. Patet D. Solari M. Oddo M. A. Ali C. Dias R. Almeida A. Vaz-Ferreira J. Silva E. Monteiro A. Cerejo A. P. Rocha A. A. Elsayed A. M. Abougabal B. N. Beshey K. M. Alzahaby S. Pozzebon A. Blandino Ortiz S. Cristallini O. Lheureux A. Brasseur J. L. Vincent J. Creteur M. Hravnak K. Yousef Y. Chang E. Crago R. M. Friedlander S. A. Abdelmonem S. A. Tahon T. A. Helmy H. S. Meligy F. Puig I. Dunn-Siegrist J. Pugin S. Gupta D. Govil S. Srinivasan S. J. Patel J. K. N A. Gupta D. S. Tomar M. Shafi R. Harne D. P. Arora N. Talwar S. Mazumdar E. E. Papakrivou D. Makris E. Manoulakas B. Tsolaki B. Karadodas E. Zakynthinos I. Palacios Garcia A. Diaz Martin V. Sanchez Encinares M. Pachón Ibañez J. Garnacho Montero G. Labrador T. Cebrero Cangueiro V. Poulose J. Koh J. W. Kam H. Yeter A. Kara O. Aktepe A. Topeli I. Tsolakoglou G. Intas P. Stergiannis A. A. Kolaros E. Chalari E. Athanasiadou A. Martika G. Fildisis V. Faivre C. Mengelle B. Favier D. Payen A. Poppe M. S. Winkler E. Mudersbach J. Schreiber M. L. Wruck E. Schwedhelm S. Kluge C. Zöllner T. Tavladaki A. M. Spanaki H. Dimitriou E. Kondili C. Choulaki E. Meleti D. Kafetzopoulos D. Georgopoulos G. Briassoulis A. García-de la Torre M. V. de la Torre-Prados T. Tsvetanova-Spasova P. Nuevo-Ortega C. Rueda-Molina A. Fernández-Porcel E. Camara-Sola L. Salido-Díaz A. García-Alcántara D. E. Meleti B. Suberviola J. Riera L. Rellan M. Sanchez J. C. Robles E. Lopez R. Vicente E. Miñambres M. Santibañez M. Le Guen J. Moore N. Mason M. Windpassinger O. Plattner E. Mascha D. I. Sessler Outcomes Research U. Melia J. Fontanet J. P. van den Berg M. Baylor College of Medicine Neurology/Neurocritical Care Houston USA Erasmus Hospital Intensive Care Medicine Brussels Belgium Centre Hospitalier Régional Orléans Réaimation Médicale Orléans France University of British Columbia Vancouver Canada University of Adelaide Discipline of Acute Care Medicine Adelaide Australia Royal Adelaide Hospital Intensive Care Adelaide Australia Griffith University Menzies Health Institute of Queensland Gold Coast Australia University of Adelaide Discipline of Medicine Adelaide Australia Kingston General Hospital Clinical Evaluation Research Unit Kingston Canada University of Oxford Nuffield Department of Clinical Neurosciences Oxford UK Oxford University Hospitals NHS Foundation Trust Neurosciences Intensive Care Unit Oxford UK King’s College Hospital Department of Neurosurgery London UK King’ College London Institute of Psychiatry Psychology and Neuroscience Department of Clinical Neuroscience London UK Rice University Computer Science Houston USA Baylor College of Medicine Neurosurgery Houston USA Baylor College of Medicine Pediatric Cardiology Houston USA University of Twente Clinical Neurophysiology Enschede Netherlands Rijnstate Hospital Neurology Arnhem Netherlands Medical Spectrum Twente Clinical Neurophysiology Enschede Netherlands Medical Spectrum Twente Intensive Care Enschede Netherlands Rijnstate Hospital Intensive Care Arnhem Netherlands CHUV Department of Intensive Care Medicine Neuroscience Critical Care Research Group Lausanne Switzerland Aga Khan University Hospital Anaesthesiology Karachi Pakistan Centro Hospitalar São João Intensive Care Porto Portugal Faculty of Medicine University of Porto Medicine Porto Portugal Faculdade de Ciências Universidade do Porto Departamento de Matemática Porto Portugal Centro de Matemática Universidade do Porto Porto Portugal The Biomedical Research Networking Center in Bioengineering Biomaterials and Nanomedicine Zaragoza Spain Centro Hospitalar

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Q&A

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Design management Review 2014年第1期25卷

作者： Woodie Flowers Sarah Stein Greenberg Richard K. Miller Srikant M. Datar Pappalardo Professor Emeritus of mechanical engineering at the Massachusetts Institute of Technology. He helped create MIT's renowned INTRODUCTION TO DESIGN COURSE. Flowers also received national recognition in his role as host for the PBS television series Scientific American Frontiers from 1990 to 1993 and received a New England EMMY Award for a special PBS program on design. He is a member of the National Academy of Engineering a Fellow of the American Association for the Advancement of Science and of the American Society of Mechanical Engineering and has received three honorary doctorates. He is a MacVicar Faculty Fellow for extraordinary contributions to undergraduate education at MIT where he is a member of the faculty advisory committee for MITX the Massachusetts Innovation & Technology Exchange. He was also the inaugural recipient of the Woodie Flowers Award from FIRST (For Inspiration and Recognition of Science and Technology). He recently received the Edward F. Church Medal and the Spira Outstanding Design Educator Award from ASME. Currently Flowers is a director or scientific advisor for four companies. He is also national advisor and chairman of the executive advisor board for FIRST. Has been managing director of the Hasso Plattner Institute of Design at Stanford University (also known as the d.school) since 2010. Previously she worked in the innovation practice of Monitor Group in the US and India and advised multinational companies on developing innovation capabilities. Her background includes developing new products and services in a number of emerging markets in Asia and Africa. In the classroom Stein Greenberg has co‐taught the d.school's foundational class Design Thinking Bootcamp and its renowned course on design for the developing world Entrepreneurial Design for Extreme Affordability. She recently launched an experimental new program featuring short‐format “pop‐up” classes. She holds an MBA from Stanford University and a BA in history from Oberlin College. Among other pursuits she s

Being a “gracious professional” is the key to leadership, whether you’re an engineer, a scientist, or an MIT professor. As managing director of Stanford University's ***, this Renaissance woman spends her time developing “adaptive learners.” Olin College's first president (and first employee) has plenty to say about engineering—and education. Rethinking the MBA at Harvard Business School.

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