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A SUCCESSFUL PLATELET-RICH PLASMA TREATMENT IN A FAWN WITH OVER-MOTHERING WOUND IN THE PERINEAL AREA

Taiwan Veterinary Journal 2023年第1N02期48卷 21-26页

作者： Huan-Yu Hsu Natcha Thongrueang Guan-Ming Ke Hsu-Hsun Lee Veterinary Medical Teaching Hospital National Pingtung University of Science and Technology Neipu Pingtung Taiwan International Degree Program in Animal Vaccine Technology International College National Pingtung University of Science and Technology Neipu Pingtung Taiwan Department of Veterinary Medicine College of Veterinary Medicine National Pingtung University of Science and Technology Neipu Pingtung Taiwan Graduate Institute of Animal Vaccine Technology College of Veterinary Medicine National Pingtung University of Science and Technology Neipu Pingtung Taiwan https://***/0000-0002-9651-6831

Over-mothering syndrome is common in intensive deer farming; the wound is usually deep and hard to take care of, and results in neonatal mortality increased by bacterial infection related to the wound. Regenerate therapy might be an option for treating severe wounds due to over-mothering syndrome. Autologous platelet-rich plasma (PRP) is a widely used method to treat orthopedic issues in humans and animals. It contains several concentrated growth factors to promote tissue regeneration, without the complications of overreaction or of rejection issues. This report presents the successful treatment of autologous PRP in a fawn with a 7 cm × 4 cm wound in the perineal area, caused by an over-mothering doe. Autologous PRP was injected on both sides of the proximal of the gluteobiceps muscle and applied 3 times over the 20-day treatment period. The wound displayed rapid tissue regeneration with no complications. This successful application of PRP is the first report to enhance the regeneration of the vulva and the anus in a large animal. The PRP was injected on the proximal of the wound rather than directly on the wound to reduce potential irritation from physical contact to the wound, and the regeneration process was nice and fast. This protocol could provide clinical veterinarians with an effective and low labor cost method to treat severe and contaminated wounds in the perineal area.

关键词： Autologous platelet-rich plasma treatment Fawn Perineal wound Over-mothering syndrome

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Innovative Facial Sculpting of the Human Skull Using 3D Scanning Techniques

Innovative Facial Sculpting of the Human Skull Using 3D Scan...

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Biomedical Engineering International Conference (BMEiCON)

作者： Somying Phuaphisit Pasuk Mahakkanukrauh Somchat Taertulakarn Graduate Program in Forensic Science Faculty of Allied Health Sciences Thammasat University Pathum Thani Thailand Department of Anatomy Faculty of Medicine Chiang Mai University Chiang Mai Thailand Department of Medical Technology Faculty of Allied Health Sciences Thammasat University Pathum Thani Thailand

ISBN: (数字)9798331505431

ISBN: (纸本)9798331505448

The identification of missing persons and the resolution of cases involving unidentified human remains have become increasingly critical issues, as the occurrence of these cases continues to increase. To address this, various methods are used to identify these individuals. One effective method involves the identification of human remains through facial reconstruction. Our study advocates for the application of 3D computerized facial reconstruction as a technique for identifying individuals from their skulls. A portable 3D scanner was employed to obtain detailed data from the skulls, making it a versatile tool suitable not only for laboratory and field settings but also for real-time data collection, which offers significant advantages in time-sensitive situations. The facial reconstruction process was carried out using the Facial Soft Tissue Thickness (FSTTs) database, which provides essential information on tissue thickness at various points on the skull, derived from the average facial soft tissue thickness of Northern Thai male donors who contributed their bodies for educational and research purposes. The reconstruction involved the use of 27 skeletal landmarks to guide the process. Autodesk Meshmixer software was used to mark and connect the mesh points of the face, while ZBrush was employed to refine and complete the facial model, resulting in a detailed reconstruction. For this research, the skull samples were obtained from individuals who had donated their bodies for scientific study. Importantly, the researchers did not have access to any photographs or images of the donors during the reconstruction process, ensuring that the work was based solely on the skull's anatomical features. An evaluation of the accuracy of these facial reconstructions is currently ongoing, and the results will be shared in future studies to assess the potential of this technique in solving cases involving unidentified remains.

关键词： Three-dimensional displays Databases Forensics Biological tissues Data collection Software Real-time systems Image reconstruction Faces Biomedical engineering

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Corrigendum to "Effect of cell imprinting on viability and drug susceptibility of breast cancer cells to doxorubicin" [Acta Biomaterialia, 2020, 113, 119-129] (Acta Biomaterialia (2020) 113 (119–129), (S1742706120303287), (10.1016/***.2020.06.007))

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Acta Biomaterialia 2025年 198卷 571-572页

作者： Shahriyari, Fatemeh Janmaleki, Mohsen Sharifi, Shahriar Hesar, Milad Eyvazi Hoshian, Sasha Taghiabadi, Reza Razaghian, Ahmad Ghadiri, Majid Peirovi, Afshin Mahmoudi, Morteza Nezhad, Amir Sanati Khademhosseini, Ali Division of Engineering in Medicine Department of Medicine Brigham and Women's Hospital Harvard Medical School CambridgeMA United States Division of Health Sciences & Technology Harvard-Massachusetts Institute of Technology Massachusetts Institute of Technology CambridgeMA United States Department of Materials Engineering Faculty of Engineering Imam Khomeini International University Qazvin Iran Biomedical Engineering Graduate Program University of Calgary Canada Precision Health Program and Department of Radiology Michigan State University East LansingMI48824 United States RWTH Aachen University Templergraben 55 Aachen52062 Germany Department of Chemistry and Materials Science Aalto University School of Chemical Engineering Espoo Finland Department of Mechanical Engineering Faculty of Engineering Imam Khomeini International University Qazvin Iran Nano-Biotechnology Department Pasteur Institute of Iran Tehran Iran Departments of Bioengineering Chemical and Biomolecular Engineering and Radiological Sciences Center for Minimally Invasive Therapeutics California NanoSystems Institute University of California – Los Angeles Los AngelesCA United States Terasaki Institute for Biomedical Innovation Los AngelesCA United States

The authors regret to report that the images for panels h (Plain PDMS) and I (MCF7-imprinted PDMS) in Fig. 3 were mistakenly taken from the same dataset, resulting in the omission of the correct image in panel h for the Plain PDMS day 7 image. We sincerely apologize for this error. For an accurate representation, please see the corrected Fig. 3 provided here along with its original figure caption. This does not affect the validity of the statistical analyses or the overall conclusions drawn from the study. © 2025

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Novel blue-pea flowers derived-carbon dots/iron oxide nanohybrid as sustainable "turn-off" fluorescent nanosensor for selective Fe3+ detection in food samples

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Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy 2025年 339卷 126291页

作者： Nuntahirun, Pattaraporn Li, Chien-Hung Sirisit, Natee Shashikumar, Uday Tsai, Pei-Chien Manjappa, Kiran B. Huang, Genin Gary Paoprasert, Peerasak Ponnusamy, Vinoth Kumar Department of Chemistry Faculty of Science and Technology Thammasat University Pathum Thani12120 Thailand Department of Medicinal and Applied Chemistry Kaohsiung Medical University Kaohsiung City807 Taiwan Graduate Program for Biomedical and Materials Science and Department of Chemistry Tunghai University Taichung City Taiwan Center of Excellence on Petrochemical and Materials Technology Chulalongkorn University Bangkok10330 Thailand Kaohsiung City807 Taiwan Kaohsiung City807 Taiwan

Developing a novel fluorescence carbon-based sensor with high sensitivity, selectivity, and rapid response is critical for detecting ferric ion (Fe3+) in beverages and food products. Overcoming this challenge is essential, as excess Fe3+ can cause cellular damage, raising health concerns. Herein, we designed a fluorescence nanosensor utilizing a hybrid iron oxide/carbon dots (HICs) nanocomposite, synthesized from blue pea (BPs) flowers and iron oxide nanoparticles through a hydrothermal treatment. More importantly, the HICs demonstrated high sensitivity and a rapid response to Fe3+, with a linear detection range spanning 0.06 to 100 µM and an impressively low limit of detection (LOD) of 13.61 nM. Moreover, the HICs exhibited remarkable selectivity toward Fe3+, remaining unaffected by various interferences, including common metal ions and small organic molecules. Upon Fe3+ addition, the fluorescence quenching of HICs occurs through a combination of static quenching and dynamic quenching mechanism and the inner filter effect. Additionally, the detection of Fe3+ in milk and herbal drinks was achieved using HICs, yielding satisfactory recovery rates ranging from 94.4 % to 103.7 %. Thus, the developed HICs serve as highly efficient "turn-off’" fluorescent nanosensors, exhibiting a rapid response, high sensitivity, and ultra-selectivity for Fe3+ detection, unaffected by matrix interference. These qualities make them promising candidates for advanced detection applications in food products, ensuring food safety. © 2025 Elsevier B.V.

关键词： Tea

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Facile synthesis of copper cobalt sulfide and nickel hydroxide tube-like composites as battery-type active material of energy storage devices

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Journal of Energy Storage 2023年 65卷

作者： Kuo, Tsung-Rong Fitriannisa, Istikhori Chung, Ren-Jei Lin, Kuan-Hsien Yougbaré, Sibidou Lin, Lu-Yin Wu, Yung-Fu International PhD Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Graduate Institute of Nanomedicine and Medical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei Taiwan BP 218 11 Nanoro Burkina Faso Department of Chemical Engineering Ming Chi University of Technology New Taipei City24301 Taiwan

Bimetallic sulfide has attracted much attentions as efficient electroactive materials of battery supercapacitor hybrid (BSH), because of numerous redox states, high conductivity and good energy efficiency. Developing composites having excellent chemical and electrochemical properties is necessary to enhance the energy storage features of bimetallic sulfides. In this study, CuCo2S4 and Ni(OH)2 composites (CuCo2S4@Ni(OH)2) are designed on Ni foam via the facial hydrothermal process and chemical bath deposition as the electroactive material of BSH at first time. Effects of Ni(OH)2 amounts on CuCo2S4 on electrochemical and physical properties of CuCo2S4@Ni(OH)2 are investigated. The physical mixed CuCo2S4 and Ni(OH)2 composite is also fabricated to verify synergistic effects of CuCo2S4@Ni(OH)2. A higher specific capacitance (CF) of 1583.9 F/g along with the capacity of 220.0 mAh/g are got for optimal CuCo2S4@Ni(OH)2 electrode, respectively comparing to 831.7 and 1063.3 F/g of CuCoS4 and Ni(OH)2 electrodes. A BSH is fabricated by the CuCo2S4@Ni(OH)2 electrode and the activated carbon electrode. The potential window of 1.6 V and maximum energy density of 32.1 Wh/kg at 1.1 kW/kg are achieved. The CF retention of 78% and Coulombic efficiency higher than 97% in 8000 charge/discharge cycles are also obtained for this BSH. © 2023

关键词： Sulfur compounds

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Patient Confidential Data Hiding and Transmission System Using Amplitude Quantization in the Frequency Domain of ECG Signals

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Sensors 2023年第22期23卷 9199-9199页

作者： Chen, Shuo-Tsung Ye, Ren-Jie Wu, Tsung-Hsien Cheng, Chun-Wen Zhan, Po-You Chen, Kuan-Ming Zhong, Wan-Yu Department of Medical Informatics Chung Shan Medical University Taichung40201 Taiwan Department of Information Center Chung Shan Medical University Hospital Taichung40201 Taiwan Graduate School of Applied Chinese Studies National Yunlin University of Science and Technology Yunlin 64002 Taiwan Bachelor’s Program in Business Management Fu Jen Catholic University New Taipei City242062 Taiwan

The transform domain provides a useful tool in the field of confidential data hiding and protection. In order to protect and transmit patients’ information and competence, this study develops an amplitude quantization system in a transform domain by hiding patients’ information in an electrocardiogram (ECG). In this system, we first consider a non-linear model with a hiding state switch to enhance the quality of the hidden ECG signals. Next, we utilize particle swarm optimization (PSO) to solve the non-linear model so as to have a good signal-to-noise ratio (SNR), root mean square error (RMSE), and relative root mean square error (rRMSE). Accordingly, the distortion of the shape in each ECG signal is tiny, while the hidden information can fulfill the needs of physiological diagnostics. The extraction of hidden information is reversely similar to a hiding procedure without primary ECG signals. Preliminary outcomes confirm the effectiveness of our proposed method, especially an Amplitude Similarity of almost 1, an Interval RMSE of almost 0, and SNRs all above 30. © 2023 by the authors.

关键词： Electrocardiograms

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A new sterol from the Formosan soft coral Lobophytum durum

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Journal of Molecular Structure 2024年第Part2期1296卷

作者： Hung, Chia-Ling Huang, Li-Chieh Shih, Kun-Yauh Lai, Kuei-Hung Peng, Bo-Rong Hwang, Tsong-Long Chien, Su-Ying Li, Chia-Ying Chung, Hsu-Ming Department of Applied Chemistry National Pingtung University Pingtung900391 Taiwan Graduate Institute of Pharmacognosy College of Pharmacy Taipei Medical University Taipei11031 Taiwan PhD Program in Clinical Drug Development of Herbal Medicine College of Pharmacy Taipei Medical University Taipei11031 Taiwan Traditional Herbal Medicine Research Center Taipei Medical University Hospital Taipei11031 Taiwan Graduate Institute of Natural Products College of Medicine Chang Gung University Taoyuan333323 Taiwan Research Center for Chinese Herbal Medicine Graduate Institute of Healthy Industry Technology College of Human Ecology Chang Gung University of Science and Technology Taoyuan333324 Taiwan Department of Chemical Engineering Ming Chi University of Technology New Taipei City243303 Taiwan Department of Anesthesiology Chang Gung Memorial Hospital Taoyuan333423 Taiwan Instrumentation Center National Taiwan University Taipei106319 Taiwan

Chromatographic investigation on the ethyl acetate extract of the soft coral Lobophytum durum collected from the waters of Guishan Island in northeast Taiwan resulted in the isolation of three sterols 1–3, including one new sterol, 3β-hydroxy-25-methylene-5-cholesten-7-one (1), and two previously reported sterols, 7-oxogorgosterol (2), and (24R)-ergostane-3β,5α,6β,25-tetraol 25-monoacetate (3). The structures of sterols 1–3 were determined by extensive spectroscopic data analysis and by comparison with literatures. Additionally, the 24R-configuration of sterol 3 was identified by a single-crystal X-ray diffraction analysis and 13C chemical shifts for first time. The anti-inflammatory activities of sterols 1–3 were evaluated by examining their inhibitory effects on the generation of superoxide anions and the release of elastase against activated human neutrophils. © 2023

关键词： Spectroscopic analysis

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Directional Neural Connectivity during Robot Mirror Therapy in Patients with Stroke

Directional Neural Connectivity during Robot Mirror Therapy ...

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Asia-Pacific Signal and Information Processing Association Annual Summit and Conference (APSIPA)

作者： Yuma Kanaizuka Takahiro Manabe Jian-Jia Huang Jen-Wen Hung Yumie Ono Electrical Engineering Program Graduate School of Science and Technology Meiji University Japan School of Science and Technology Meiji University Japan Department of Rehabilitation Chang Gung Memorial Hospital-Kaohsiung Medical Center Kaohsiung Taiwan School of Medicine College of Medicine Chang Gung University Taoyuan Taiwan

This study explored directional connectivity networks during hand movement training in stroke patients using 8 conditions combining mirror therapy, robot-assisted bimanual therapy, and object manipulation. The findings revealed that mirror therapy and robot-assisted bimanual therapy decreased interhemispheric inward connectivity to the affected motor cortex in the left-hand paralyzed patient, reducing inhibitory control. Conversely, these interventions increased interhemispheric inward connectivity in the right-hand paralyzed patient, suggesting enhanced excitatory connectivity. The results emphasized the influence of neurorehabilitation methods, hemiparesis severity, and affected side on interhemispheric connectivity. Further research is needed to develop personalized rehabilitation strategies based on directional connectivity measures.

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Analysis of the Musculoskeletal Load Generated when a Small Dog Walks on a Slippery Floor*

Analysis of the Musculoskeletal Load Generated when a Small ...

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IEEE/SICE International Symposium on System Integration

作者： Shijian Li Daisuke Chugo Satoshi Muramatsu Sho Yokota Jin-Hua She Hiroshi Hashimoto Uemura Takashi Hiroaki Kamishina Yoshiharu Hata Takayuki Yamada Takahiro Uchida Graduate School of Science and Technology Kwansei Gakuin University Sanda Japan School of Information Science and Technology Tokai University Hiratsuka Japan Faculty of Science and Engineering Toyo University Kawagoe Japan School of Engineering Tokyo University of Technology Tokyo Japan Master Program of Innovation for Design and Engineering Advanced Institute of Industrial Technology Tokyo Japan KyotoAR Animal Advanced Medical Center Kyoto Japan Rinrei Co. Ltd. Tokyo Japan

ISBN: (数字)9798331531614

ISBN: (纸本)9798331531621

The objective of this paper is to identify the stresses placed on the musculoskeletal system when small dogs walk on floors with low friction coefficients. In many households, and small dogs in particular are often kept indoors. According to veterinary experience, it is known that small dogs kept indoors that walk with their lower limbs slipping cause a great deal of stress on the musculoskeletal system, and that the incidence of joint disease in the lower limbs of such small dogs is high. In this study, we measured the body movements of small dogs walking on slippery floors using a three-dimensional motion capture system and force plate system. Furthermore, by inputting these measurements into the musculoskeletal simulation model we have developed to simulate the musculoskeletal system of dogs, we derived the load on the musculoskeletal system of small dogs on slippery and non-slippery floors. As a result, it was identified that walking on a slippery floor causes a strong load on the lower limb muscles of small dogs.

关键词： Legged locomotion Limbs Friction Dogs System integration Muscles Object recognition Floors Stress Paints

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Dual-Targeting EGCG/NO-Supplying protein assembled nanoparticles with Multi-Synergistic effects against atherosclerosis

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Chemical Engineering Journal 2024年 493卷

作者： Lin, Chi Cheng, Tsai-Mu Liu, Yun-Chun Hsu, Fang-Yu Shih, Chun-Ming Tsai, Min-Lang Shih, Chun-Che Mi, Fwu-Long Graduate Institute of Medical Sciences College of Medicine Taipei Medical University Taipei11031 Taiwan The PhD Program for Translational Medicine College of Medical Science and Technology Taipei Medical University Taipei11031 Taiwan Taipei Heart Institute Taipei Medical University Taipei11031 Taiwan Department of Food Science National Taiwan Ocean University Keelung20224 Taiwan Department of Biochemistry and Molecular Cell Biology School of Medicine College of Medicine Taipei Medical University Taipei11031 Taiwan Division of Cardiology and Cardiovascular Research Center Taipei Medical University Hospital Taipei11031 Taiwan Division of Cardiovascular Surgery Department of Surgery Wan Fang Hospital Taipei Medical University Taipei11031 Taiwan Institute of Clinical Medicine School of Medicine National Yang-Ming Chiao Tung University Taipei Taiwan Department of Surgery School of Medicine College of Medicine Taipei Medical University Taipei11031 Taiwan Graduate Institute of Nanomedicine and Medical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan International Ph.D. Program for Cell Therapy and Regeneration Medicine College of Medicine Taipei Medical University Taipei Taiwan

Limited therapeutic options are available to effectively preventing atherosclerosis. Inflammatory endothelial cells, foamy macrophages, and high protease levels contribute to atherosclerotic plaque formation. Studies have shown that catechins effectively scavenge reactive oxygen species (ROS), inhibit monocyte adhesion and reduce cholesterol levels, while nitric oxide (NO) enhances endothelial function. However, due to the poor stability and bioavailability of catechins and the toxicity from the burst release of current synthetic small molecules NO donor, effective delivery of these bioactive compounds to treat atherosclerosis is still a challenge. Herein, a catechin/protein-based NO donor co-delivery nanosystem was designed for combinatorial anti-atherosclerotic therapy. We engineered a (−)-epigallocatechin-3-gallate (EGCG)/NO-releasing protein co-assembled nanocomplex based on specific catechin-protein interactions. Furthermore, the nanocomplex was surface modified with fucoidan (Fu), a sulfated polysaccharide with anti-inflammatory activity. This nanocomplex exhibits sensitivity to ROS, pH, and enzymes. The Fu-functionalized nanoparticles specifically accumulates in atherosclerotic plaques mediated by P-selectin on inflamed endothelial cells and scavenger receptor A (SR-A) on foamy macrophages. Under environmental stimuli that simulate the condition of plaque, the nanoparticles are readily activated to release EGCG and NO in response to excess ROS and high protease levels, exerting the multi-synergistic anti-atherosclerosic effects on reducing monocyte adhesion, promoting NO production to proliferate endothelial cells, lowering ROS levels, and decreasing the foam cell formation in vitro, and reducing lipid accumulation, plaque size, and inflammatory cytokines release in high-fat diet-induced atherosclerosis model in ApoE−/− mice. The integration of plaques targeting ability and multiple therapeutic functions can provide an advanced therapeutic strategy for athero

关键词： Nitric oxide

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