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Mesenchymal Stromal/Stem Cells Know Best:The Remarkable Complexities of Its InteractionsWith Polymorphonuclear Neutrophils

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Stem Cells 2024年第5期42卷 403-415页

作者： Wang, Li-Tzu Lee, Wei Liu, Ko-Jiunn Sytwu, Huey-Kang Yen, Men-Luh Linju Yen, B. Department of Obstetrics and Gynecology National Taiwan University (NTU) Hospital College of Medicine NTU Taipei Taiwan School of Medical Laboratory Science and Biotechnology College of Medical Science and Technology Taipei Medical University Taipei Taiwan Ph.D. Program in Medical Biotechnology College of Medical Science and Technology Taipei Medical University Taipei Taiwan Regenerative Medicine Research Group Institute of Cellular and System Medicine National Health Research Institutes (NHRI) Zhunan Taiwan Cell Therapy Center China Medical University Hospital Taichung Taiwan National Institute of Cancer Research NHRI Tainan Taiwan National Institute of Infectious Diseases and Vaccinology NHRI Zhunan Taiwan Department and Graduate Institute of Microbiology and Immunology National Defense Medical Center Taipei Taiwan

Polymorphonuclear neutrophils (PMNs), the predominant immune cell type in humans, have long been known as first-line effector cells against bacterial infections mainly through phagocytosis and production of reactive oxygen species (ROS). However, recent research has unveiled novel and pivotal roles of these abundant but short-lived granulocytes in health and disease. Human mesenchymal stromal/stem cells (MSCs), renowned for their regenerative properties and modulation of T lymphocytes from effector to regulatory phenotypes, exhibit complex and context-dependent interactions with PMNs. Regardless of species or source, MSCs strongly abrogate PMN apoptosis, a critical determinant of PMN function, except if PMNs are highly stimulated. MSCs also have the capacity to fine-tune PMN activation, particularly in terms of CD11b expression and phagocytosis. Moreover, MSCs can modulate numerous other PMN functions, spanning migration, ROS production, and neutrophil extracellular trap (NET) formation/NETosis, but directionality is remarkably dependent on the underlying context: in normal nondiseased conditions, MSCs enhance PMN migration and ROS production, whereas in inflammatory conditions, MSCs reduce both these functions and NETosis. Furthermore, the state of the MSCs themselves, whether isolated from diseased or healthy donors, and the specific secreted products and molecules, can impact interactions with PMNs;while healthy MSCs prevent PMN infiltration and NETosis, MSCs isolated from patients with cancer promote these functions. This comprehensive analysis highlights the intricate interplay between PMNs and MSCs and its profound relevance in healthy and pathological conditions, shedding light on how to best strategize the use of MSCs in the expanding list of diseases with PMN involvement. © The Author(s) 2024. Published by Oxford University Press.

关键词： : polymorphonuclear neutrophils apoptosis CD11b mesenchymal stromal/stem cells migration NETosis phagocytosis reactive oxygen species

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Verification of the Inactivation Effect of Near-UV LEDs using a Pulsed Lighting System on Staphylococcus aureus

Verification of the Inactivation Effect of Near-UV LEDs usin...

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2024 IEEE Sustainable Smart Lighting World Conference and Expo, LS24 2024

作者： Nomura, Hiroki Kihara, Seiji Zukeran, Akinori Sawai, Jun Misu, Takayuki Kanagawa Institute of Technology Graduate School of Engineering Master's Degree Program in Electrical and Electronic Engineering Atsugi Kanagawa243-0292 Japan Kanagawa Institute of Technology Faculty of Engineering Department of Electrical and Electronic Engineering Atsugi Kanagawa243-0292 Japan Kanagawa Institute of Technology Faculty of Health and Medical Sciences Department of Nutrition and Life Science Atsugi Kanagawa243-0292 Japan

ISBN: (纸本)9798331540197

The purpose of this study is to investigate the disinfection effect of Near-UV LED light, which is pulsed using PWM control, on Staphylococcus aureus. To evaluate the disinfection effect of Near-UV LED light, three types of Near-UV LEDs with wavelengths of 395 nm, 385 nm, and 365 nm were installed within a sealed space inside an incubator and energized with a forward current of 1000 mA and a forward voltage of 3.6 V, and the disinfection rate under each type of light was assessed. Additionally, the disinfection effect was evaluated when the same three types of Near-UV LEDs were pulsed with a 50% duty cycle. As a result, 100% disinfection was achieved with 365 nm Near-UV LED direct-current irradiation for 120 seconds, and a 93% disinfection rate was obtained with pulsed irradiation for 150 seconds. © 2024 IEEE.

关键词： Light emitting diodes

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Node-Level Lymph Node Automatic Segmentation in CT Images Using Deep Parallel Structure-Related 3D U-Net Variant 21st

Node-Level Lymph Node Automatic Segmentation in CT Images Us...

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21st Pacific Rim International Conference on Artificial Intelligence, PRICAI 2024

作者： Cheng, Shi Li, Quan Zhang, Guangyu Zhang, Lei Peng, Tao School of Future Science and Engineering Soochow University Suzhou China Center of Stomatology The Second Affiliated Hospital of Soochow University Suzhou China Division of Cardiology Department of Internal Medicine Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China Graduate Program of Medical Physics and Data Science Research Center Duke Kunshan University Jiangsu Kunshan China

ISBN: (纸本)9789819601240

The delineation of Lymph Nodes (LNs) is pivotal in pinpointing therapeutic targets for radiotherapy in head and neck malignancies. Nevertheless, this endeavor poses a formidable challenge, primarily stemming from the suboptimal contrast against adjacent tissues. This investigation introduces a deep learning methodology aimed at automating the segmentation of LNs within CT scans, offering the following contributions: (1) Expanding upon the 3D Unet model, we incorporate a parallel block consisting of attention gate and squeeze & excitation modules. We extensively evaluate various versions of this parallel block and achieve favorable performance. (2) To address the slow decrease in Dice loss, we introduce a lightweight boundary refinement module. Our proposed method is assessed on a dataset comprising 103 patients and 603 Lymph Nodes (LNs), with 452 nodes used for training and 151 nodes for testing. The node-level Dice similarity coefficient achieved by our method reaches an impressive 0.833. © The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2025.

关键词： Computerized tomography

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Application of LDPE Film–Loaded Nutmeg Essential Oil Pickering Emulsion to Extend Tilapia Fillets’ Shelf Life

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Food and Bioprocess technology 2024年第10期17卷 3031-3045页

作者： Yudhistira, Bara Chang, Chao-Kai Punthi, Fuangfah Cheng, Kuan-Chen Husnayain, Naila Hsieh, Chang-Wei Department of Food Science and Biotechnology National Chung Hsing University Taichung City402 Taiwan Department of Food Science and Technology Sebelas Maret University Surakarta City Central Java57126 Indonesia Institute of Biotechnology National Taiwan University Taipei10617 Taiwan Graduate Institute of Food Science Technology National Taiwan University Taipei10617 Taiwan Department of Optometry Asia University Taichung City413305 Taiwan Department of Medical Research China Medical University Hospital Taichung City404333 Taiwan International Master Program of Agriculture National Chung Hsing University Taichung City402 Taiwan

The food industry is still dependent on plastics for packaging materials, primarily due to their effectiveness in safeguarding products from external factors, such as moisture, light, and gas. However, traditional plastic packaging lacks the ability to actively preserve the quality and extend the shelf life of food. To address this challenge, various methods are currently being developed through surface modifications and the incorporation of active compounds. In most cases, studies on the modification of active film using low-pressure plasma (LPP) use different parameters, including time, pressure, and power, without a systematic optimization process. Therefore, this study aims to determine the optimum parameters for the combination of LPP treatment and Pickering emulsion (PE) of nutmeg essential oil (NEO) using Taguchi’s orthogonal assay design (OAD) to produce LDPE-active film. The results showed that the optimum conditions were 15 W LPP power, 30 s LPP duration time, and 1.5% PE-NEO concentration. These results showed a 50% improvement in power and time efficiency. LDPE film–loaded PE-NEO was then applied to tilapia fillets in cold storage. The results showed that the TBARS and TBVN values of the samples after the treatment were lower than those of the control by 12.11% and 16.74%, respectively. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.

关键词： Cold storage

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Exploration of anti-leukemic effect of soft coral-derived 13-acetoxysarcocrassolide: Induction of apoptosis via oxidative stress as a potent inhibitor of heat shock protein 90 and topoisomerase II

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Kaohsiung Journal of medical Sciences 2023年第7期39卷 718-731页

作者： Chin, Hsien-Kuo Lu, Mei-Chin Hsu, Kai-Cheng El-Shazly, Mohamed Tsai, Tsen-Ni Lin, Tzu-Yung Shih, Shou-Ping Lin, Tony Eight Wen, Zhi-Hong Yang, Yu-Chen S. H. Liu, Yi-Chang Department of Marine Biotechnology and Resources National Sun Yat-Sen University Kaohsiung Taiwan Division of Cardiovascular Surgery Department of Surgery Kaohsiung Armed Forces General Hospital Kaohsiung Taiwan Graduate Institute of Marine Biology National Dong Hwa University Hualien Taiwan National Museum of Marine Biology and Aquarium Pingtung Taiwan Graduate Institute of Cancer Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University Taipei Taiwan Master Program for Cancer Molecular Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University Taipei Taiwan Ph.D. Program for Cancer Molecular Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University Taipei Taiwan TMU Research Center of Drug Discovery Taipei Medical University Taipei Taiwan Department of Pharmacognosy Faculty of Pharmacy Ain-Shams University Cairo Egypt Division of Hematology-Oncology Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Taiwan Department and Graduate Institute of Aquaculture National Kaohsiung University of Science and Technology Kaohsiung Taiwan Doctoral Degree Program in Marine Biotechnology National Sun Yat-Sen University Kaohsiung Taiwan Doctoral Degree Program in Marine Biotechnology Academia Sinica Taipei Taiwan Joint Biobank Office of Human Research Taipei Medical University Taipei Taiwan Department of Internal Medicine Faculty of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan Cellular Therapy and Research Center Kaohsiung Medical University Hospital Kaohsiung Taiwan

13-Acetoxysarcocrassolide (13-AC) is a marine cembranoid derived from the aquaculture soft coral of Lobophytum crassum. The cytotoxic effect of 13-AC against leukemia cells was previously reported but its mechanism of action is still unexplored. In the current study, we showed that 13-AC induced apoptosis of human acute lymphoblastic leukemia Molt4 cells, as evidenced by the cleavage of PARP and caspases, phosphatidylserine externalization, as well as the disruption of mitochondrial membrane potential. The use of N-acetylcysteine (NAC), a reactive oxygen species (ROS) scavenger, attenuated the cytotoxic effect induced by 13-AC. Molecular docking and thermal shift assay indicated that the cytotoxic mechanism of action of 13-AC involved the inhibition of heat shock protein 90 (Hsp 90) activity by eliciting the level of Hsp 70 and topoisomerase IIα in Molt4 cells. 13-AC also exhibited potent antitumor activity by reducing the tumor volume (48.3%) and weight (72.5%) in the in vivo Molt4 xenograft mice model. Our findings suggested that the marine cembranoid, 13-AC, acted as a dual inhibitor of Hsp 90 and topoisomerase IIα, exerting more potent apoptotic activity via the enhancement of ROS generation. © 2023 The Authors. The Kaohsiung Journal of medical Sciences published by John Wiley & Sons Australia, Ltd on behalf of Kaohsiung medical University.

关键词： 13-Acetoxysarcocrassolide heat shock protein 90 leukemia oxidative stress topoisomerase II

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Fabrication of versatile poly(xylitol sebacate)-co-poly(ethylene glycol) hydrogels through multifunctional crosslinkers and dynamic bonds for wound healing

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Acta Biomaterialia 2023年 170卷 344-359页

作者： Yeh, Ying-Yu Lin, Yi-Yun Wang, Ting-Teng Yeh, Yu-Jia Chiu, Ting-Hsiang Wang, Reuben Bai, Meng-Yi Yeh, Yi-Cheun Institute of Polymer Science and Engineering National Taiwan University Taipei Taiwan Institute of Biomedical Engineering National Taiwan University Taipei Taiwan Biomedical Engineering Program Graduate Institute of Applied Science and Technology National Taiwan University of Science and Technology Taipei Taiwan Institute of Food Safety and Health National Taiwan University Taipei Taiwan Graduate Institute of Biomedical Engineering National Taiwan University of Science and Technology Taipei Taiwan Adjunct Appointment to the Department of Biomedical Engineering National Defense Medical Center Taipei Taiwan Program National Taiwan University Taipei Taiwan GIP-TRIAD Master's Degree in Agro-Biomedical Science National Taiwan University Taipei Taiwan

Poly(polyol sebacate) (PPS) polymer family has been recognized as promising biomaterials for biomedical applications with their characteristics of easy production, elasticity, biodegradation, and cytocompatibility. Poly(xylitol sebacate)-co-poly(ethylene glycol) (PXS-co-PEG) has been developed to fabricate PPS-based hydrogels;however, current PXS-co-PEG hydrogels presented limited properties and functions due to the limitations of the crosslinkers and crosslinking chemistry used in the hydrogel formation. Here, we fabricate a new type of PXS-co-PEG hydrogels through the use of multifunctional crosslinkers as well as dynamic bonds. In our design, polyethyleneimine-polydopamine (PEI-PDA) macromers are utilized to crosslink aldehyde-functionalized PXS-co-PEG (APP) through imine bonds and hydrogen bonds. PEI-PDA/APP hydrogels present multiple functional properties (e.g., fluorescent, elastomeric, biodegradable, self-healing, bioadhesive, antioxidant, and antibacterial behaviors). These properties of PEI-PDA/APP hydrogels can be fine-tuned by changing the PDA grafting degrees in the PEI-PDA crosslinkers. Most importantly, PEI-PDA/APP hydrogels are considered promising wound dressings to promote tissue remodeling and prevent bacterial infection in vivo. Taken together, PEI-PDA/APP hydrogels have been demonstrated as versatile biomaterials to provide multiple tailorable properties and desirable functions to expand the utility of PPS-based hydrogels for advanced biomedical applications. Statement of significance: Various strategies have been developed to fabricate poly(polyol sebacate) (PPS)-based hydrogels. However, current PPS-based hydrogels present limited properties and functions due to the limitations of the crosslinkers and crosslinking chemistry used in the hydrogel formation. This work describes that co-engineering crosslinkers and interfacial crosslinking is a promising approach to synthesizing a new type of poly(xylitol sebacate)-co-poly(ethylene glycol) (PXS-co-

关键词： Polyols

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Momordica charantia fruit extract with antioxidant capacity improves the expression of tyrosine-phosphorylated proteins in epididymal fluid of chronic stress rats

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Journal of Integrative Medicine 2022年第6期20卷 534-542页

作者： Supatcharee Arun Therachon Kamollerd Nareelak Tangsrisakda Sudtida Bunsueb Arada Chaiyamoon Alexander Tsang-Hsien Wu Sitthichai Iamsaard Department of Anatomy Faculty of MedicineKhon Kaen UniversityKhon Kaen 40002Thailand Research Institute for Human High Performance and Health Promotion(HHP&HP) Khon Kaen UniversityKhon Kaen 40002Thailand The PhD Program for Translational Medicine College of Medical Science and TechnologyTaipei Medical University and Academia SinicaTaipei 11031TaiwanChina Graduate Institute of Medical Sciences National Defense Medical CenterTaipei 114TaiwanChina

Objective:Although the protective effects of Momordica charantia L.(MC)extract on chemical-induced testicular damage have been studied,the preventive effects of MC extract on functional proteins in the epididymis under chronic stress have never been *** study investigated the protective effects of MC fruit extract on protein secretion,especially tyrosine-phosphorylated proteins,in the epididymis of rats exposed to chronic unpredictable stress(CUS).Methods:Total phenolic compounds(TPC),total flavonoid compounds(TFC)and antioxidant capacities of MC extract were *** male rats were divided into 4 groups:control group,CUS group,and 2groups of CUS that received different doses of MC extract(40 or 80 mg/kg).In treated groups,rats were given MC daily,followed by induction of CUS(1 stressor was randomly applied from a battery of 9 potential stressors)for 60 consecutive *** corticosterone and testosterone levels were analyzed after the end of *** of heat-shock protein 70(HSP-70)and tyrosine-phosphorylated proteins present in the fluid of the head and tail of the epididymis were quantified using Western ***:MC extract contained TPC of(19.005±0.270)mg gallic acid equivalents and TFC of(0.306±0.012)mg catechin equivalents per gram,and had 2,2-diphenyl-1-picrylhydrazyl antioxidant capacity of(4.985±0.086)mg trolox equivalents per gram,radical 50%inhibitory concentration of(2.011±0.008)mg/mL and ferric reducing antioxidant power of(23.697±0.819)μmol Fe(Ⅱ)per *** level in the epididymis was significantly increased,while the corticosterone level was significantly improved in groups treated with MC extract,compared to the CUS ***,an 80 mg/kg dose of MC extract prevented the impairments of HSP-70 and tyrosine-phosphorylated protein expressions in the luminal fluid of the epididymis of CUS ***:MC fruit extract had antioxidant activities and improved the functional proteins secreted from

关键词： Momordica charantia L. Antioxidant activity Epididymis Tyrosine-phosphorylated proteins Chronic unpredictable stress

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Pilot Study of Distinct Graphs Models in Analysis of Brain Aging in Resting-State Functional Connectivity Networks

Pilot Study of Distinct Graphs Models in Analysis of Brain A...

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18th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2025

作者： Carvalho, M.A.G. Frayne, R. School of Technology University of Campinas Brazil Radiology and Clinical Neurosciences Hotchkiss Brain Institute Univ. of Calgary Canada Seaman Family MR Research Centre Foothills Medical Centre Calgary Canada Biomedical Engineering Graduate Program University of Calgary Canada Calgary Image Processing and Analysis Centre Foothills Medical Centre Calgary Canada

Graphs have been used successfully to represent and analyze brain networks for many decades. Such structural and functional studies are important for revealing interactions between distinct areas of the brain that, for ex ample, are associated with the performance of a specific task or the onset of a cognitive disorder like dementia. In this pilot study, resting-state functional magnetic resonance imaging data were acquired in a sex-balanced sample of 10 young (20.1±2.1 years) and 10 old (65.6±0.4 years), presumed healthy, adults. We examined the effects of age on whole-brain resting-state functional connectivity (RSFC) networks. We examined two main graph modeling approaches to analyze RSFC networks. These approaches employ different strategies or graph models for thresholding over the complete network or examining changes in graph density. We com puted and compared one graph metric, the modularity, that was derived from the RSFC network graph models. Considering the need for a model that must preserve the network’s connectivity, strategies that use spanning trees as seeds to gradually increase the graph’s density seem more appropriate to represent brain networks. © 2025 by SCITEPRESS– Science and technology Publications, Lda.

关键词： Magnetic resonance imaging

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First Results on Graph Similarity Search in Resting-State Functional Connectivity Networks Using Spectral and Graph Edit Distances

First Results on Graph Similarity Search in Resting-State Fu...

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18th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2025

The application of graph theory in the modeling and analysis of brain networks has generated both new op portunities as well as new challenges in neuroscience. Resting state functional connectivity (RSFC) networks studied with graphs is an important field of investigation because of the potential benefits in understanding function in healthy individuals and identifying evidence of brain diseases and injury in patients. This work is unique because it applies information retrieval techniques to create ranked lists from RSFC graph theory derived networks. In our analysis, we used a sample of whole-brain resting-state functional magnetic reso nance imaging (rs-fMRI) data obtained from Young (n = 10, age: 20.1±2.1) and Old (n = 10, 65.6±0.4) sex-balanced groups drawn from a healthy, i.e., neurotypical, cohort. We estimated two well-known distance metrics (graph edit distance and graph spectral distance) and by using information-retrieval graph ranking methods achieved precision measures at the top-5 positions of ranked lists of up to 80%. © 2025 by SCITEPRESS– Science and technology Publications, Lda.

关键词： Graph neural networks

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Rhodiola and Salidroside Attenuate Oxidative Stress-Triggered H9c2 Cardiomyoblast Apoptosis Through IGF1R-Induced ERK1/2 Activation

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Environmental Toxicology 2024年第11期39卷 5150-5161页

作者： Ju, I-Ju Tsai, Bruce Chi-Kang Kuo, Wei-Wen Kuo, Chia-Hua Lin, Yueh-Min Hsieh, Dennis Jine-Yuan Pai, Pei-Ying Huang, Shang-En Lu, Shang-Yeh Lee, Shin-Da Huang, Chih-Yang Division of General Medicine Department of Medical Education Tri-Service General Hospital National Defense Medical Center Taipei Taiwan Department of Neurological Surgery Tri-Service General Hospital National Defense Medical Center Taipei Taiwan Cardiovascular and Mitochondrial Related Disease Research Center Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien Taiwan Department of Biological Science and Technology College of Life Sciences China Medical University Taichung Taiwan Ph.D. Program for Biotechnology Industry China Medical University Taichung Taiwan School of Pharmacy China Medical University Taichung Taiwan Laboratory of Exercise Biochemistry University of Taipei Taipei Taiwan Institute of Sports Sciences University of Taipei Taipei Taiwan Department of Kinesiology and Health Science College of William and Mary WilliamsburgVA United States School of Physical Education and Sports Science Soochow University Jiangsu Suzhou China Department of Pathology Changhua Christian Hospital Changhua Taiwan School of Medicine Chung Shan Medical University Taichung Taiwan School of Medical Laboratory and Biotechnology Chung Shan Medical University Taichung Taiwan Clinical Laboratory Chung Shan Medical University Hospital Taichung Taiwan Division of Cardiovascular Medicine Department of Internal Medicine China Medical University Hospital Taichung Taiwan School of Medicine College of Medicine China Medical University Taichung Taiwan Graduate Institute of Chinese Medicine China Medical University Taichung Taiwan Graduate Institute of Biomedical Sciences China Medical University Taichung Taiwan School of Rehabilitation Science Shanghai University of Traditional Chinese Medicine Shanghai China School of Rehabilitation Medicine Weifang Medical University Shandong Weifang China Department of Physical Therapy Graduate Institute of Rehabilitation Science China Medical University Taichung Taiwan Department of Medical Research China Medic

Oxidative stress is a pivotal factor in the pathogenesis of various cardiovascular diseases. Rhodiola, a traditional Chinese medicine, is recognized for its potent antioxidant properties. Salidroside, a phenylpropanoid glycoside derived from Rhodiola rosea, has shown remarkable antioxidant capabilities. This study aimed to elucidate the potential protective mechanisms of Rhodiola and salidroside against H2O2-induced cardiac apoptosis in H9c2 cardiomyoblast cells. H9c2 cells were exposed to H2O2 for 4 h, and subsequently treated with Rhodiola or salidroside for 24 h. Cell viability and apoptotic pathways were assessed. The involvement of insulin-like growth factor 1 receptor (IGF1R) and the activation of extracellular regulated protein kinases 1/2 (ERK1/2) were investigated. H2O2 (100 μM) exposure significantly induced cardiac apoptosis in H9c2 cells. However, treatment with Rhodiola (12.5, 25, and 50 μg/mL) and salidroside (0.1, 1, and 10 nM) effectively attenuated H2O2-induced cytotoxicity and apoptosis. This protective effect was associated with IGF1R-activated phosphorylation of ERK1/2, leading to the inhibition of Fas-dependent proteins, HIF-1α, Bax, and Bak expression in H9c2 cells. The images from hematoxylin and eosin staining and immunofluorescence assays also revealed the protective effects of Rhodiola and salidroside in H9c2 cells against oxidative damage. Our findings suggest that Rhodiola and salidroside possess antioxidative properties that mitigate H2O2-induced apoptosis in H9c2 cells. The protective mechanisms involve the activation of IGF1R and subsequent phosphorylation of ERK1/2. These results propose Rhodiola and salidroside as potential therapeutic agents for cardiomyocyte cytotoxicity and apoptosis induced by oxidative stress in heart diseases. Future studies may explore their clinical applications in cardiac health. © 2024 Wiley Periodicals LLC.

关键词： Cell death

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