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Global Clock Coordination by the Brain Clock in the Suprachiasmatic Nucleus Through Relay and Amplification of Diffusible and Neural Signaling

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European Journal of neuroscience 2025年第8期61卷

作者： Silver, Rae Yao, Yifan Myung, Jihwan Department of Psychology Columbia University New York NY United States Department of Neuroscience and Behavior Barnard College New York NY United States Department of Pathology and Cell Biology Columbia University Medical School New York NY United States Zuckerman Institute Affiliate Columbia University New York NY United States Graduate Institute of Mind Brain and Consciousness Taipei Medical University New Taipei City Taiwan Graduate Institute of Medical Sciences Taipei Medical University Taipei Taiwan Ph.D. Program in Neuroscience of Cognition and Consciousness Taipei Medical University New Taipei City Taiwan

The brain clock located in the suprachiasmatic nucleus (SCN) of the hypothalamus receives direct retinal input, thereby providing the entire body with an internal representation of external solar time. The pathways by which this small nucleus signals so broadly involve co-occurring nervous and diffusible output signals, although the latter are less understood. Portal pathways, such as the well-known pituitary portal pathway, provide a mechanism, whereby signals of neural origin can reach local, specialized targets without suffering dilution in the systemic blood supply. Newly discovered vascular pathways involve direct connections between each of the sensory circumventricular nuclei at its point of attachment to the brain. These nuclei line the brain's ventricles, and their leaky blood vessels and large perivascular spaces represent a route, whereby secretions from the SCN can be relayed and then amplified, providing a pathway to achieve global coordination of circadian clock signaling. This review provides a narrative that incorporates our understanding of SCN neural and diffusible output signals, with particular emphasis on the contribution of brain fluidic compartments and the fluids therein. © 2025 Federation of European neuroscience Societies and John Wiley & Sons Ltd.

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Non-Invasive Neuromodulation of Adult ADHD: Investigation of the Effects of an Individualized Theta tACS Protocol

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Brain Stimulation 2025年第1期18卷 556-556页

作者： Senturk, Hansa Akturk, Tuba Hanoglu, Lutfu Department of Neuroscience Graduate School of Health Sciences Istanbul Medipol University Turkey Program of Electroneurophysiology Istanbul Medipol University Turkey Research Institute for Health Sciences and Technologies (SABITA) Istanbul Medipol University Turkey Section Brain Stimulation and Cognition Department of Cognitive Neuroscience Faculty of Psychology and Neuroscience Maastricht University The Netherlands Department of Neurology School of Medicine Istanbul Medipol University Turkey

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Temperature and toxic Tau in Alzheimer's disease: new insights

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Temperature 2015年第4期2卷 491-498页

作者： Carrettiero, Daniel Carneiro Santiago, Fernando Enrique Motzko-Soares, Anna Carolina Parracho Almeida, Maria Camila Graduate Program in Neuroscience and Cognition

Alzheimer's disease (AD), the most common dementia in the elderly, is characterized by cognitive impairment and severe autonomic symptoms such as disturbance in core body temperature (Tc), which may be predictors or early events in AD onset. Inclusions of phosphorylated Tau (p-Tau) are a hallmark of AD and other neurodegenerative disorders called “Tauopathies.” Animal and human studies show that anesthesia augments p-Tau levels through reduction of Tc, with implications for AD. Additionally, hypothermia impairs memory and cognitive function. The molecular networks related to Tc that are associated with AD remain poorly characterized. Under physiological conditions, Tau binds microtubules, promoting their assembly and stability. The dynamically regulated Tau-microtubule interaction plays an important role in structural remodeling of the cytoskeleton, having important functions in neuronal plasticity and memory in the hippocampus. Hypothermia-induced increases in p-Tau levels are significant, with an 80% increase for each degree Celsius below normothermic conditions. Although the effects of temperature on Tau phosphorylation are evident, its effects on p-Tau degradation remain poorly understoodWe review information concerning the mechanisms of Tau regulation of neuron plasticity via its effects on microtubule dynamics, with focus on pathways regulating the abundance of phosphorylated Tau species. We highlight the effects of temperature on molecular mechanisms influencing the development of Tau-related diseases. Specifically, we argue that cold might preferentially affects central nervous system structures that are highly reliant upon plasticity, such as the hippocampus, and that the effect of cold on Tau phosphorylation may constitute a pathology-initiating trigger leading to neurodegeneration. © 2015, © 2015 The Author(s). Published with license by Taylor & Francis. © 2015, © Daniel Carneiro Carrettiero, Fernando Enrique Santiago, Anna Carolina Parracho Motzko-Soare

关键词： Alzheimer's disease brain plasticity hippocampus hypothermia memory and degradation microtubule dynamics tauopathy temperature

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Motor cortex repetitive transcranial magnetic stimulation in fibromyalgia: a multicentre randomised controlled trial

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British Journal of Anaesthesia 2025年第6期134卷 1756-1764页

作者： Silva, Valquíria A. Baptista, Abrahão F. Fonseca, Alessandra S. Carneiro, Adriana M. Brunoni, André R. Carrilho, Paulo.E.M. Lins, Catarina C. Kubota, Gabriel T. Fernandes, Ana Mércia B.L. Lapa, Jorge.D.S. dos Santos, Lucas M. Sasso, Ivo Monte-Silva, Katia Poindessous-Jazat, Frédérique Mori, Nobuhiko Miki, Kenji Baltar, Adriana Tanaka, Clarice Teixeira, Manoel J. Hosomi, Koichi Bouhassira, Didier Attal, Nadine Ciampi de Andrade, Daniel LIM 62 - Pain Center Department of Neurology São Paulo Brazil Service of Interdisciplinary Neuromodulation (SIN) Department and Institute of Psychiatry São Paulo Brazil Medical-Surgical Nursing Department University of São Paulo São Paulo Brazil Center for Mathematics Computation and Cognition Federal University of ABC São Paulo Brazil Mood Disorder Program (Pro-GRUDA) Department of Psychiatry University of São Paulo São Paulo Brazil Medicine School “Professor Orival Alves” State University of Western Paraná (UNIOESTE) Paraná Brazil Neurosurgery Unit Hospital de Cirurgia Sergipe Aracaju Brazil Department of Medicine Federal University of Sergipe Sergipe São Cristóvão Brazil LIM 54 - Physiotherapy Research Laboratory University of São Paulo São Paulo Brazil Applied Neuroscience Laboratory Universidade Federal de Pernambuco Cidade Universitária Pernambuco Brazil UVSQ-Paris-Saclay University Ambroise Paré Hospital Boulogne-Billancourt U987 France Department of Neurosurgery Osaka University Graduate School of Medicine Osaka Japan Faculty of Health Science Osaka Yukioka College of Health Science Osaka Japan Center for Pain Management Hayaishi Hospital Osaka Japan Center for Neuroplasticity and Pain (CNAP) Department of Health Science and Technology University of Aalborg Gistrup Denmark

Background: Despite affecting 2–4% of the population worldwide, fibromyalgia often remains refractory to treatment. Here we report the first international randomised double-blind, sham-controlled trial developed to assess the efficacy of repetitive transcranial magnetic stimulation (rTMS) as an add-on therapy for fibromyalgia. Methods: Women aged ≥18 yr with fibromyalgia refractory to best available treatment were enrolled in Brazil, France, and Japan, and randomised to 10 Hz motor cortex (M1) rTMS, 3000 pulses day⁻¹, or sham stimulation. This included 10 induction sessions over 2 weeks, followed by weekly maintenance (6 weeks), and fortnightly extended maintenance (8 weeks). Primary outcome was ≥50% pain reduction at week 8 compared with baseline. Secondary outcomes included pain interference, mood, global impression of change, and Fibromyalgia Impact Questionnaire (FIQ) scores at weeks 8 and 16. Results: We randomised 101 women (mean age 48 [range 25-83] yr) into active (n=52) or sham (n=49) arms. Bayesian analysis revealed a 99.4% probability of ≥50% pain reduction at week 8 in the active group vs sham (odds ratio [OR] 3.04;95% credible interval [95% CrI] 1.26–8.06), with a number needed to treat of 4.54. Frequentist analysis confirmed that relative pain reduction was higher in the active than in the sham group (40.4% vs 18.4%, P=0.028). At week 16, this probability reduced to 34.2% (OR 0.815;95% CrI 0.313–2.1), but the likelihood of FIQ score reduction was 79.1%. The intervention appeared safe. Conclusions: Add-on M1-repetitive transcranial magnetic stimulation reduced pain intensity up to 8 weeks in women with fibromyalgia. Although analgesic effects waned, functional improvements remained during extended maintenance at week 16. © 2025 The Authors

关键词： chronic pain clinical trial fibromyalgia neuromodulation transcranial magnetic stimulation

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Current understanding on the neurophysiology of behavioral thermoregulation

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Temperature 2015年第4期2卷 483-490页

作者： Almeida, Maria Camila Vizin, Robson Cristiano Lillo Carrettiero, Daniel Carneiro Natural and Humanities Science Center Graduate Program in Neuroscience and Cognition

Temperature influence on the physiology and biochemistry of living organisms has long been recognized, which propels research in the field of thermoregulation. With the cloning and characterization of the transient receptor potential (TRP) ion channels as the principal temperature sensors of the mammalian somatosensory neurons, the understanding, at a molecular level, of thermosensory and thermoregulatory mechanisms became promising. Because thermal environment can be extremely hostile (temperature range on earth's surface is from ∼ −69°C to 58°C), living organisms developed an array of thermoregulatory strategies to guarantee survival, which include both autonomic mechanisms, which aim at increasing or decreasing heat exchange between body, and ambient and behavioral strategies. The knowledge regarding neural mechanisms involved in autonomic thermoregulatory strategies has progressed immensely compared to the knowledge on behavioral thermoregulation. This review aims at collecting the up-to-date knowledge on the neural basis for behavioral thermoregulation in mammals in order to point out perspectives and deployment of this research field. © 2015, © 2015 The Author(s). Published with license by Taylor & Francis. © 2015, © Maria Camila Almeida, Robson Cristiano Lillo Vizin, and Daniel Carneiro Carrettiero.

关键词： grooming operant thermoregulatory behavior thermo-TRP thermogradient

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Reserpine-Induced Progressive Parkinsonism in Mice Predisposed and Non-Predisposed to Depressive-Like Behavior

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Journal of Behavioral and Brain Science 2021年第11期11卷 267-279页

作者： Manuela B. L. Soares Leonardo B. Lopes-Silva Marcela Becegato Vinicius S. Bioni Alvaro C. Lima Gabriela M. Ferreira Ywlliane Meurer Regina H. Silva Behavioral Neuroscience Laboratory Department of Pharmacology Federal University of S&atilde o Paulo S&atilde o Paulo Brazil Memory and Cognition Studies Laboratory Post-Graduate Program of Cognitive Neuroscience and Behavior Department of Psychology Federal University of Paraíba Jo&atilde o Pessoa Brazil

Parkinson’s disease (PD) is a progressive degenerative condition that mainly affects the elderly. The disease comprises motor symptoms such as tremors at rest, loss of voluntary movement, decreased muscle strength, propensity to lean forward and acceleration of the walking pace. These signs are related to the degeneration of the nigrostriatal dopaminergic pathway. Patients also have non-motor symptoms, among which sleep alterations, cognitive deficits, fatigue, pain and depression stand out. Although depression has been described as the most prevalent non-motor symptom, it is not clear whether this mood disorder is due to PD or patients would already have a greater predisposition. The present study evaluated the relationship between the predisposition to depressive-like behavior and the development of motor alterations in a progressive pharmacological model of PD in mice. Mice were classified into groups of depressive-like propensities and submitted to the pharmacological model. Reserpine was administrated at 0.1 mg/kg on alternate days for 40 days. The catalepsy and oral movement tests were used to evaluate motor alterations, the sucrose preference test was used to evaluate anhedonia, and the open field test was applied to evaluate general activity. Reserpine promoted parkinsonian motor impairments, and there were no differences between animals from different depressive-like behavior profiles. Thus, it was not possible to find a relationship between parkinsonism and the propensity to depression based on the basal sucrose preference test. More studies with other evaluations of depressive-like behavior are needed to confirm the results found in our study.

关键词： Parkinson’s Disease Depression Reserpine Mice

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Warmth-sensitive channels in thermoregulation: TRPV3 and TRPV4

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Autonomic neuroscience 2015年 192卷 52-53页

作者： Maria Camila Almeida Robson Cristiano Lillo Vizin Carolina da Silveira Scarpellini Débora Ishikawa Gabriela Monteiro Correa Cristiane Oliveira de Souza Luciane Helena Gargaglioni Daniel C. Carrettiero Kênia Cardoso Bícego Graduate Program on Neuroscience and Cognition Universidade Federal do ABC (UFABC) Natural and Humanities Science Center Universidade Federal do ABC (UFABC) Brazil Department of Animal Morphology and Physiology College of Agricultural and Veterinary Sciences São Paulo State University (UNESP) Brazil Joint UFSCar-UNESP Graduate Program of Physiological Sciences Brazil National Institute of Science and Technology in Comparative Physiology (INCT – Fisiologia Comparada) Brazil

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Photonic smart bandage for wound healing assessment

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Photonics Research 2021年第3期9卷 272-280页

作者： Arnaldo Leal-Junior Jingjing Guo Rui Min Antonio Jose Fernandes Anselmo Frizera Carlos Marques Telecommunications Laboratory(LABTEL) Graduate Program in Electrical EngineeringFederal University of Espi’rito SantoVitoria-ES 29075-910Brazil School of Instrumentation and Optoelectronic Engineering Beihang UniversityBeijing 100191China Center for Cognition and Neuroergonomics State Key Laboratory of Cognitive Neuroscience and LearningBeijing Normal UniversityZhuhai 519087China Physics Department&I3N Universidade de AveiroCampus Universitario de SantiagoAveiro 3810-193Portugal

Chronic wounds affect around 2% of the world population with an annual multi-billion dollar cost to the healthcare system. This background pushes the development of new therapies and procedures for wound healing and its assessment. Among them, the potential of hydrogen(pH) assessment is an important indicator of the wound healing stage and condition. This paper presents the development of the first optical fiber-embedded smart wound dressing for pH assessment. An intrinsically pH-sensitive optical fiber is fabricated using a polydimethylsiloxane(PDMS) precursor doped with rhodamine B dye. Raman and Fourier transform infrared(FTIR) spectroscopies are performed in order to verify the presence of rhodamine B and PDMS in the fiber samples. Then, the fiber is embedded in gauze fabric and hydrocolloid wound dressing. In addition, such low Young’s modulus of PDMS fiber enables its use as a highly sensitive pressure sensor, where the results show that the fiber-embedded bandage can measure pressures as low as 0.1 kPa with a high linearity in the range of 0 to 0.3 kPa. The smart bandage is subjected to different pH, which resulted in a wavelength shift of 0.67 nm/pH when the absorption peak at 515 nm was analyzed. Furthermore, pH increase leads to linear decrease of the transmitted optical power(R2 of 0.998), with rise and fall times below 20 s and 30 s, respectively. Therefore, the proposed optical fiber-embedded smart bandage enables the simultaneous assessment of pressure and pH on the wound region.

关键词： fiber smart healing

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The definition of sng: The expert consensus by the sng taxonomy Task force of the Taiwan sng Society

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Journal of the Formosan Medical Association 2025年

作者： Han, Der-Sheng Lin, Jiann-Her Hung, Chih-Hsien Huang, Shuping Chen, Jen-Yin Chiang, Yung-Hsiao Chiu, Hsiao-Yean Chou, Li-Wei Hsieh, Cheng-Ta Huang, Ming-Chyi Huang, Wei-Lieh Kang, Jiunn-Horng Lee, Hsun-Hua Lin, Chia-Shu Lin, Chien-Min Lin, Chih-Peng Lin, Ying-Tung Liu, Yen-Chin Ro, Long-Sun Shen, Chiung-Chyi Su, Lily I-Wen Su, Yu-Jih Sun, Jui-Ming Sung, Jia-Ying Tsai, Rong-Kung Wang, Man-Ling Wen, Yeong-Ray Weng, Hao-Jui Wu, Ming-Shun Yu, Yu-Wen Hsieh, Sung-Tsang Wang, Shuu-Jiun Sun, Wei-Zen Chen, Chih-Cheng Department of Physical Medicine and Rehabilitation National Taiwan University Hospital Beihu Branch Taipei Taiwan Department of Physical Medicine and Rehabilitation National Taiwan University College of Medicine Taipei Taiwan Division of Neurosurgery Department of Surgery Taipei Medical University Hospital Taipei Taiwan Department of Surgery School of Medicine College of Medicine Taipei Medical University Taipei Taiwan Taipei Neuroscience Institute Taipei Medical University Taipei Taiwan TMU Research Center of Neuroscience Taipei Medical University Taipei Taiwan Department of Neurology Kaohsiung Medical University Hospital Kaohsiung Taiwan School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan Department of Foreign Languages and Literature National Sun Yat-sen University Kaohsiung Taiwan Department of Anesthesiology Chi Mei Medical Center Tainan Taiwan School of Medicine College of Medicine National Sun Yat-sen University Kaohsiung Taiwan School of Nursing College of Nursing Taipei Medical University Taipei Taiwan Department of Nursing Taipei Medical University Hospital Taipei Taiwan Department of Physical Medicine and Rehabilitation China Medical University Hospital Taichung Taiwan Department of Physical Medicine and Rehabilitation Asia University Hospital Asia University Taichung Taiwan Department of Physical Therapy and Graduate Institute of Rehabilitation Science China Medical University Taichung Taiwan Division of Neurosurgery Department of Surgery Cathay General Hospital Taipei Taiwan School of Medicine National Tsing-Hua University Hsinchu Taiwan Department of Medicine School of Medicine Fu Jen Catholic University New Taipei City Taiwan Department of Psychiatry Taipei City Psychiatric Center Taipei City Hospital Taipei Taiwan Department of Psychiatry National Taiwan University Hospital Yunlin Branch Yunlin Taiwan Department of Physical Medicine and Rehabilitation Taipei Medical University Hospital Taip

“Sng” is a Taiwanese term describing a distinct state of soreness. Accumulating evidence indicates that sng is a specific somatosensory modality, independent of pain, with distinct receptors and transduction pathways. In recent years, variations in its presentation across different medical specialties have highlighted the need for a standardized definition of sng-related terminology. To address this, the Taiwan Sng Society established a multidisciplinary Sng Taxonomy Task Force, comprising 32 experts in both clinical and basic sciences related to sng. Here we summarize the discussions and expert consensus from the Task Force. A total of 16 sng-related terminology was defined. The first edition of sng terminology aims to establish a clear, standardized framework for the clinical practice and research of sng. © 2025 Formosan Medical Association

关键词： Definition sng Sngception Taxonomy Terminology

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Visual representations in the human brain are aligned with large language models

arXiv

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arXiv 2022年

作者： Doerig, Adrien Kietzmann, Tim C. Allen, Emily Wu, Yihan Naselaris, Thomas Kay, Kendrick Charest, Ian Institute of Cognitive Science University of Osnabrück Germany Donders Institute for Brain Cognition & Behaviour Nijmegen Netherlands Department of Radiology University of Minnesota MinneapolisMN United States Department of Psychology University of Minnesota MinneapolisMN United States Graduate Program in Cognitive Science University of Minnesota MinneapolisMN United States Department of Neuroscience University of Minnesota MinneapolisMN United States cerebrUM Département de Psychologie Université de Montréal Montréal Canada Center for Human Brain Health School of Psychology University of Birmingham Birmingham United Kingdom

The human brain extracts complex information from visual inputs, including objects, their spatial and semantic interrelations, and their interactions with the environment. However, a quantitative approach for studying this information remains elusive. Here, we test whether the contextual information encoded in large language models (LLMs) is beneficial for modelling the complex visual information extracted by the brain from natural scenes. We show that LLM embeddings of scene captions successfully characterise brain activity evoked by viewing the natural scenes. This mapping captures selectivities of different brain areas, and is sufficiently robust that accurate scene captions can be reconstructed from brain activity. Using carefully controlled model comparisons, we then proceed to show that the accuracy with which LLM representations match brain representations derives from the ability of LLMs to integrate complex information contained in scene captions beyond that conveyed by individual words. Finally, we train deep neural network models to transform image inputs into LLM representations. Remarkably, these networks learn representations that are better aligned with brain representations than a large number of state-of-the-art alternative models, despite being trained on orders-of-magnitude less data. Overall, our results suggest that LLM embeddings of scene captions provide a representational format that accounts for complex information extracted by the brain from visual inputs. Copyright © 2022, The Authors. All rights reserved.

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