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DISTINCT COGNITIVE TRAJECTORIES IN LATE MIDDLE-AGE AND THEIR ASSOCIATIONS WITH BRAIN STRUCTURE AND ALZHEIMER'S DISEASE BIOMARKERS: FINDINGS FROM THE WISCONSIN REGISTRY FOR ALZHEIMER’S PREVENTION

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Alzheimer's & Dementia 2016年第7期12卷 P306-P307页

作者： Lindsay R. Clark Rebecca L. Koscik Sara Elizabeth Berman Annie M. Racine Kimberly D. Mueller Cynthia M. Carlsson Christopher R. Nicholas Sanjay Asthana Kaj Blennow Henrik Zetterberg Sterling C. Johnson Wisconsin Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health Madison WI USA Wisconsin Alzheimer's Institute University of Wisconsin School of Medicine and Public Health Madison WI USA University of Wisconsin School of Medicine and Public Health: Medical Scientist Training Program Madison WI USA Neuroscience Training Program University of Wisconsin Madison WI USA Institute on Aging University of Wisconsin Madison WI USA Neuroscience and Public Policy Program University of Wisconsin Madison WI USA Department of Communication Sciences and Disorders University of Wisconsin-Madison Madison WI USA Geriatric Research Education and Clinical Center Wm. S. Middleton Veterans Hospital Madison WI USA Institute of Neuroscience and Physiology The Sahlgrenska Academy at University of Gothenburg Gothenburg Sweden University College London Institute of Neurology London United Kingdom Waisman Laboratory for Brain Imaging and Behavior University of Wisconsin-Madison Madison WI USA

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Hematopoietic stem and progenitor cells harbor provirus with identical Gag and V3 sequences as residual plasma virus in optimally treated patients

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Journal of Virus Eradication 2015年 1卷 34-34页

作者： V.H. Terry N.T. Sebastian R. Yucha F. Taschuk L.A. McNamara A. Onafuwa-Nuga J. Riddell D. Bixby K.L. Collins Department of Internal Medicine University of Michigan Medical School Ann Arbor MI USA Cellular and Molecular Biology Graduate Program University of Michigan Medical School Ann Arbor MI USA Medical Scientist Training Program University of Michigan Medical School Ann Arbor MI USA Department of Microbiology and Immunology University of Michigan Medical School Ann Arbor MI USA

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Ryanodine受体的功能结构和调节因子

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中国细胞生物学学报 2015年第1期37卷 6-15页

作者：范娟杨瑾周鑫董治龙王李阳 MengMeng Xu 牟玉莲 Miyuki Nishi Williams Issacs 安书成 Hiroshi Takeshima Jianjie Ma 徐学红陕西师范大学生命科学学院细胞遗传及发育生物学实验室西安710062 兰州大学第二医院兰州730030 Medical Scientist Training Program Duke University Medical Center 中国农业科学院北京畜牧兽医研究所北京100093 Graduate School of Pharmaceutical Sciences Kyoto University School of Medicine Johns Hopkins University School of Medicine Ohio State University

Ryanodine受体(ryanodine receptor,Ry R)是位于细胞内内质网/肌浆网膜上的钙离子释放通道蛋白。Ry R是由四个足状结构的亚单位组成的同源四聚体,每个亚单位大于550 k Da,四聚体的总分子量超过2 MDa,是迄今发现的内质网/肌浆网膜上最大... 详细信息

Ryanodine受体(ryanodine receptor,Ry R)是位于细胞内内质网/肌浆网膜上的钙离子释放通道蛋白。Ry R是由四个足状结构的亚单位组成的同源四聚体,每个亚单位大于550 k Da,四聚体的总分子量超过2 MDa,是迄今发现的内质网/肌浆网膜上最大的离子通道。哺乳动物有三种类型的Ry R,其中Ry R1主要分布在骨骼肌中,Ry R2首先发现于心肌,Ry R3主要在脑中有较多分布。Ry R钙离子释放通道在肌肉收缩、突触传递、激素分泌、蛋白折叠和程控性凋亡以及坏死等一系列以细胞功能为基础的生理过程中起着极其重要的作用,因而近些年在医学生物学和药学应用上都有极大的进展。该文就Ry R在机体中的分布、功能结构和调节因子等进行了介绍,其蛋白调节因子二氢吡啶受体(dihydropyridine receptor,DHPR)、钙调蛋白(Calmodulin)、隐钙素(calsequestrin)、FKBP(FK506-binding protein)家族蛋白和小分子调节因子咖啡因、离子等都是Ry R复合体行使细胞生理功能必不可少的因素。

关键词： RyR 功能结构调节因子

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Immunotherapy Bridge 2016 and Melanoma Bridge 2016: meeting abstracts

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Journal of Translational Medicine 2017年第1期15卷 1-14页

作者： Vera Hirsh Sandro Pignata Melissa Bersanelli Donatello Gasparro Francesco Leonardi Sebastiano Buti Letizia Gnetti Cinzia Azzoni Lorena Bottarelli Enrico Maria Silini Erik Wennerberg Sandra Demaria Claire Vanpouille-Box Karsten Pilones Nils Rudqvist Julie Diamond Silvia Formenti Aranzazu Mediero Bruce Cronstein Zachary S. Morris Emily I. Guy David M. Francis Monica M. Gressett Eric A. Armstrong Shyhmin Huang Jacquelyn A. Hank Anna Hoefges Alexander L. Rakhmilevich Paul M. Harari Paul M. Sondel Stephen D. Gilles Alan J. Korman Yared Hailemichael Willem W. Overwijk Per thor Straten Alessandro Lugli Heather Dawson Annika Blank Inti Zlobec Luigi Fattore Susan Costantini Maria Elena Pisanu Paolo Antonio Ascierto Gennaro Ciliberto Debora Malpicci Mario Acunzo Giulia Romano Giovanni Nigita Carlo Maria Croce Alessandro Laganà Ciro Francesco Ruggiero Alessia Noto Claudia De Vitis Rita Mancini Michael Postow Jason Luke David Stroncek Luciano Castiello Wenjing Chen Ping Jin Jiaqiang Ren Marianna Sabatino Soldano Ferrone Connie PM Duong Marie Vetizou Laurence Zitvogel Marcella Occelli Carolina Cauchi Cristiana Lo Nigro Chiara Varamo Daniela Vivenza Silvia Violante Laura Lattanzio Marco Carlo Merlano Grazia Sciancalepore Giuseppe Forte Michela Rovera Zelda Seia Stefania Palazzini Fabiana Errico Davide Basso Laura Quaranta Fulvio Lavagna Paolo Bosio Duane Moogk Shi Zhong Victoria Fang Janna Dougherty Arianne Perez-Garcia Iman Osman Michelle Krogsgaard Zhiya Yu Nicholas P. Restifo Ivan Liadi Navin Varadarajan William Rittase Cheng Zhu Alan Frey Timea Balatoni Gabriella Liszkay Miklós Kasler Anita Moho Timea Sebestyén Anita Varga Judit Oláh Zsuzsanna Lengyel Gabriella Emri Andrea Ladányi Beatrice Polini Stefano Fogli Sara Carpi Maria Cristina Breschi Paola Nieri Barbara Pardini Alessio Naccarati Nevio Dubbini Antonella Romanini Francesca Morgese Davide Soldato Silvia Pagliaretta Riccardo Giampieri Silvia Rinaldi Mariangela Torniai Agnese Savini Azzurra Onofri Francesca Bianchi Rossana Berardi Donatella Brancorsini Anna Campanati McGill University Health Centre Cedars Cancer Centre Montreal QC Canada Dipartimento Uro-Ginecologico S.C. Oncologia Medica Uro-Ginecologica Istituto Nazionale Tumori Fondazione “G. Pascale” Napoli Italy Medical Oncology University Hospital of Parma Via Gramsci 14 43126 Parma PR Italy Anatomic Pathology Unit University Hospital of Parma Via Gramsci 14 43126 Parma PR Italy Weill Cornell Medicine Cornell University New York NY USA Department of Radiation Oncology Weill Cornell Medical College New York NY USA New York University Langone Medical Center New York NY USA Dept. of Human Oncology School of Medicine and Public Health University of Wisconsin Madison WI USA Provenance Biopharmaceuticals Carlisle MA USA Bristol-Myers Squibb Company Redwood City CA USA Department of Melanoma Medical Oncology The University of Texas MD Anderson Cancer Center Houston TX USA Department of Hematology Center for Cancer Immune Therapy (CCIT) University Hospital Herlev Copenhagen Denmark Department of Immunology and Microbiology University of Copenhagen Copenhagen Denmark Institute of Pathology University of Bern Bern Switzerland Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione G. Pascale” Naples Italy Dipartimento di Chirurgia “P. Valdoni” Sapienza Università di Roma Rome Italy IRCCS Pascale Naples Italy Dipartimento Melanoma Tessuti molli Muscolo-Scheletrico e Testa-Collo Oncologia Medica Melanoma Immunoterapia Oncologica e Terapie Innovative Istituto Nazionale Tumori “G. Pascale” Via M. Semmola 80131 Naples Italy Dipartimento di Medicina Sperimentale e Clinica Università degli Studi di Catanzaro “Magna Graecia” Catanzaro Italy Department of Molecular Virology Immunology and Medical Genetics The Ohio State University Comprehensive Cancer Center Columbus OH USA Department of Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai New York NY USA Dipartimento di Medicina Clinica e Molecolare Sapienza Università di Roma Rome

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XXIV World Allergy Congress 2015 Seoul, Korea. 14-17 October 2015 Abstracts

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WORLD ALLERGY ORGANIZATION JOURNAL 2016年第1期9卷 1-206页

作者： [Anonymous] Korea University College of Medicine Guro Hospital Seoul South Korea College of Medicine Korea University Seoul South Korea Korea University Guro Hospital Seoul South Korea Seoul National University Boramae Hospital Seoul South Korea Division of Clinical Immunology Faculty of Medicine University of Debrecen Debrecen Hungary Meiji Pharmaceutical University Tokyo Japan Suri Medical Foundation Hospital Uttar Pradesh State India Shahid Beheshti University Tehran Iran Airlangga University Teaching Hospital Surabaya Indonesia Tokyo Metropolitan Police Hospital Tokyo Japan Shinichiro KogaSamsung Changwon Hospital Seoul South Korea Sapporo Tokushukai Hospital Sapporo Japan Department of Dermatology Yonsei University College of Medicine Seoul South Korea Brain Korea 21 PLUS Project for Medical Science Yonsei University College of Medicine Seoul South Korea Sureyyapasa Chest Diseases and Chest Surgery Training Hospital Istanbul Turkey Kangnam Sacred Heart Hospital Seoul South Korea Sakai City Medical Center Sakai Japan Osaka University Suita Japan Yonsei University College of Medicine Seoul South Korea Osaka-Minami Medical Center Kawachinagano Japan Inha University College of Medicine Incheon South Korea Inha University Hospital Incheon South Korea Center for Rhinology and Allergology Wiesbaden Wiesbaden Germany Leti Pharma Gmbh Witten Germany Postgraduate Institute of Medical Education and Research Chandigarh India West Bengal Technical University Kolkata India Institute of Microbiology Academy of Sciences of the Czech Republic Prague Czech Republic Seoul National University Hospital Seoul South Korea Ent and Allergy Centre(INDIA) Panchkula India University of Santo Tomas Hospital Manila Philippines University of Santo Tomas Faculty of Medicine Manila Philippines Kyung Hee University Hospital at Gang-Dong Seoul South Korea Sangji University Wonju South Korea Division of Allergy and Immunology Department of Internal Medicine Yonsei University Colle

A1 Pirfenidone inhibits TGF-b1-induced extracellular matrix production in nasal polyp-derived fibroblasts Jae-Min Shin, Heung-Man Lee, Il-Ho Park A2 The efficacy of a 2-week course of oral steroid in the treatment of chronic spontaneous urticaria refractory to antihistamines Hyun-Sun Yoon, Gyeong Yul Park A3 The altered distribution of follicular t helper cells may predict a more pronounced clinical course of primary sjögren’s syndrome Margit Zeher A4 Betamethasone suppresses Th2 cell development induced by langerhans cell like dendritic cells Katsuhiko Matsui, Saki Tamai, Reiko Ikeda A5 An evaluation of variousallergens in cases of allergic bronchial asthma at lucknow and neighbouring districts by intradermal skintest Drsushil Suri, Dranu Suri A6 Evaluation ferqency of ADHD in childhood asthma Marzieh Heidarzadeh Arani A7 Steven johnson syndrome caused by typhoid fever in a child Azwin Lubis, Anang Endaryanto A8 Chronic Bronchitis with Radio Contrast Media Hypersensitivity: A Case with Hypothesized GINA Step 1 Asthma Shinichiro Koga A9 The association between asthma and depression in Korean adult : An analysis of the fifth korea national health and nutrition examination survey (2010-2012) Lee Ju Suk A10 Management of allergic disease exacerbations in pregnancy Yasunobu Tsuzuki A11 Subcutaneous immunotherapy mouse model for atopic dermatitis Seo Hyeong Kim, Jung U Shin, Ji Yeon Noh, Shan Jin, Shan Jin, Hemin Lee, Jungsoo Lee, Chang Ook Park, Kwang Hoon Lee, Kwang Hoon Lee A12 Atopic disease and/or atopy are risk factors for local anesthetic allergy in patients with history of hypersensitivity reactions to drugs? Fatma Merve Tepetam A13 Food hypersensitivity in patients with atopic dermatitis in Korea Chun Wook Park, Jee Hee Son, Soo Ick Cho, Yong Se Cho, Yun Sun Byun, Yoon Seok Yang, Bo Young Chung, Hye One Kim, Hee Jin Cho A14 Anaphylaxis caused by an ant (Brachyponera chinensis) in Japan Yoshinori Katada, Toshio Tanaka, Akihiko Nakabayashi, Koji Nishida, Kenichi A

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The relationship between intracranial vascular health and metrics of Alzheimer's disease

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Alzheimer's & Dementia 2015年第7期11卷 P793-P794页

作者： Sara Elizabeth Berman Leonardo Rivera Oliver Wieben Annie M. Racine Lindsay R. Clark Cynthia M. Carlsson Barbara B. Bendlin Lisa C. Bratzke Howard A. Rowley Patrick Turski Henrik Zetterberg Kaj Blennow Sanjay Asthana Sterling C. Johnson University of Wisconsin School of Medicine and Public Health Medical Scientist Training Program Madison WI USA University of Wisconsin-Madison Neuroscience Training Program Madison WI USA Wisconsin Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health Madison WI USA Wisconsin Alzheimer's Institute University of Wisconsin School of Medicine and Public Health Madison WI USA University of Wisconsin-Madison Madison WI USA Neuroscience Training Program University of Wisconsin Madison WI USA Neuroscience and Public Policy Program University of Wisconsin Madison WI USA Geriatric Research Education and Clinical Center Wm. S. Middleton Veterans Hospital Madison WI USA School of Nursing University of Wisconsin School of Medicine and Public Health Madison WI USA University of Wisconsin School of Medicine and Public Health Madison WI USA Clinical Neurochemistry Laboratory Institute of Neuroscience and Physiology The Sahlgrenska Academy at the University of Gothenburg Mölndal Sweden UCL Institute of Neurology London United Kingdom Waisman Laboratory for Brain Imaging and Behavior University of Wisconsin-Madison Madison WI USA

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P1-204: Insulin resistance is associated with altered microstructure in the medial temporal lobe and fornix of cognitively healthyApoEε4 carriers

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Alzheimer's & Dementia 2015年第7S_PART_9期11卷

作者： Erika Jane Starks Joseph Patrick O'Grady Siobhan M. Hoscheidt Annie M. Racine Ozioma C. Okonkwo Henrik Zetterberg Cynthia M. Carlsson Howard A. Rowley Kaj Blennow Sanjay Asthana Nagesh Adluru Andrew L. Alexander Carey E. Gleason N. Maritza Dowling LeAnn DeRungs Nancy J. Davenport Mark A. Sager Sterling C. Johnson Barbara B. Bendlin University of Wisconsin Alzheimer's Disease Research Center Madison WI USA Medical Scientist Training Program Madison WI USA University of Wisconsin School of Medicine and Public Health Madison WI USA Neuroscience Training Program Madison WI USA Alzheimer's Disease Research Center Madison WI USA Wisconsin Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health Madison WI USA Institute on Aging University of Wisconsin Madison WI USA Neuroscience Training Program University of Wisconsin Madison WI USA Neuroscience and Public Policy Program University of Wisconsin Madison WI USA Geriatric Research Education and Clinical Center Wm. S. Middleton Veterans Hospital Madison WI USA Wisconsin Alzheimer's Institute University of Wisconsin School of Medicine and Public Health Madison WI USA Clinical Neurochemistry Laboratory Institute of Neuroscience and Physiology The Sahlgrenska Academy at the University of Gothenburg Mölndal Sweden Waisman Laboratory for Brain Imaging and Behavior at University of Wisconsin-Madison Madison WI USA Department of Psychiatry University of Wisconsin-Madison Madison WI USA Department of Medical Physics University of Wisconsin School of Medicine and Public Health Madison WI USA Waisman Laboratory for Brain Imaging and Behavior University of Wisconsin-Madison Madison WI USA Wisconsin Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health Madsion WI USA

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Insulin resistance is associated with altered microstructure in the medial temporal lobe and fornix of cognitively healthy ApoE ε4 carriers

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Alzheimer's & Dementia 2015年第7期11卷 P427-P428页

作者： Erika Jane Starks Joseph Patrick O'Grady Siobhan M. Hoscheidt Annie M. Racine Ozioma C. Okonkwo Henrik Zetterberg Cynthia M. Carlsson Howard A. Rowley Kaj Blennow Sanjay Asthana Nagesh Adluru Andrew L. Alexander Carey E. Gleason N. Maritza Dowling LeAnn DeRungs Nancy J. Davenport Mark A. Sager Sterling C. Johnson Barbara B. Bendlin University of Wisconsin Alzheimer's Disease Research Center Madison WI USA Medical Scientist Training Program Madison WI USA University of Wisconsin School of Medicine and Public Health Madison WI USA Neuroscience Training Program Madison WI USA Alzheimer's Disease Research Center Madison WI USA Wisconsin Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health Madison WI USA Institute on Aging University of Wisconsin Madison WI USA Neuroscience Training Program University of Wisconsin Madison WI USA Neuroscience and Public Policy Program University of Wisconsin Madison WI USA Geriatric Research Education and Clinical Center Wm. S. Middleton Veterans Hospital Madison WI USA Wisconsin Alzheimer's Institute University of Wisconsin School of Medicine and Public Health Madison WI USA Clinical Neurochemistry Laboratory Institute of Neuroscience and Physiology the Sahlgrenska Academy at the University of Gothenburg Mölndal Sweden Waisman Laboratory for Brain Imaging and Behavior at University of Wisconsin-Madison Madison WI USA Department of Psychiatry University of Wisconsin-Madison Madison WI USA Department of Medical Physics University of Wisconsin School of Medicine and Public Health Madison WI USA Waisman Laboratory for Brain Imaging and Behavior University of Wisconsin-Madison Madison WI USA Wisconsin Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health Madsion WI USA Wisconsin Alzheimer’s Institute University of Wisconsin School of Medicine and Public Health Madison WI USA Wisconsin Alzheimer's Institute University of Wisconsin School of Medicine and Public Health Madison WI USA Madison WI USA

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P113. Learning volitional control of functional connectivity: Effects on behaviour

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Clinical Neurophysiology 2015年第8期126卷 e104-e104页

作者： D. Singh Kajal J. Mellinger S. Ruiz M. Sacchet E. Fetz N. Birbaumer R. Sitaram C. Braun Universität Tübingen MEG-Zentrum Tübingen Germany Universität Tübingen Graduate Training Center Tübingen Germany Universität Tübingen Institute of Medical Psychology Tübingen Germany Pontificia Universidad Catolica de Chile Departamento de Psiquiatría Santiago Chile Stanford University School of Medicine Neuroscience Program Stanford United States Stanford University Department of Psychology Stanford United States University of Washington Department of Physiology and Biophysics Seattle United States San Camillo Hospital Scientific Institute for Research Hospitalization and Health Care Venice Italy University of Florida Department of Biomedical Engineering Gainsville United States Sri Chitra Tirunal Institute for Medical Sciences and Technology Trivandrum India Università degli Studi di Trento CIMeC Centro interdipartimentale Mente e Cervello Trento Italy

Cerebral information processing involves the activation of brain regions and the exchange of information between them. As metric for intra-cortical communication, coherence, a frequency specific measure quantifying the correlation of the amplitudes across trials of two phase-locked signals, has been suggested. A value of 0 indicates that both signals are unrelated, a value of 1 that both signals are fully synchronized. It is evidenced by the plethora of findings that the functional connectivity between brain regions is modulated by brain states, mental processing and the planning and execution of actions. Thus, it might be hypothesized that volitionally modulating the functional connectivity between two interacting brain regions should have an impact either on behavior or cognition. The purpose of the study was to test whether subjects can learn to volitionally modulate brain functional connectivity between left and right motor cortices employing a neurofeedback training and whether the neurofeedback training induces specific effects on motor function. Thirty right-handed subjects participated in the study. The subject group was partitioned into two sub-groups, namely contingent feedback group and sham feedback group, consisting of fifteen subjects. During the neurofeedback training the magnetic brain activity originating from left and right primary motor cortices was recorded using magnetoencephalography (MEG) and a feedback signal representing the coherence between the primary motor cortices of both hemispheres was presented to the subjects on a screen. Subjects receiving contingent feedback were trained to increase coherence while the discriminative stimulus S D+ was presented and to decrease coherence while the S D− was presented. A pretest and posttest examination served to examine whether acquired control on functional connectivity evidences any behavioral effects. During pre- and posttest subjects had to perform a complex bimanual finger tapping task while th

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RABL6A Promotes Oxaliplatin Resistance in Tumor Cells and Is a New Marker of Survival for Resected Pancreatic Ductal Adenocarcinoma Patients

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Genes and Cancer 2013年第7-8期4卷 273-284页

作者： Muniz, Viviane P. Askeland, Ryan W. Zhang, Xuefeng Reed, Sara M. Tompkins, Van S. Hagen, Jussara McDowell, Bradley D. Button, Anna Smith, Brian J. Weydert, Jamie A. Mezhir, James J. Quelle, Dawn E. The Molecular and Cellular Biology Graduate Program University of Iowa Iowa City IA United States Department of Pathology College of Medicine University of Iowa Iowa City IA United States Department of Pharmacology College of Medicine University of Iowa Iowa City IA United States The Medical Scientist Training Program University of Iowa Iowa City IA United States Holden Comprehensive Cancer Center University of Iowa Iowa City IA United States Department of Biostatistics College of Medicine University of Iowa Iowa City IA United States Department of Surgery College of Medicine University of Iowa Iowa City IA United States

Pancreatic ductal adenocarcinoma (PDAC) is characterized by early recurrence following pancreatectomy, rapid progression, and chemoresistance. Novel prognostic and predictive biomarkers are urgently needed to both stratify patients for clinical trials and select patients for adjuvant therapy regimens. This study sought to determine the biological significance of RABL6A (RAB, member RAS oncogene family-like protein 6 isoform A), a novel pancreatic protein, in PDAC. Analyses of RABL6A protein expression in PDAC specimens from 73 patients who underwent pancreatic resection showed that RABL6A levels are altered in 74% of tumors relative to adjacent benign ductal epithelium. Undetectable RABL6A expression, found in 7% (5/73) of patients, correlated with improved overall survival (range 41 to 118 months with 3/5 patients still living), while patients with RABL6A expression had a worse outcome (range 3.3 to 100 months, median survival 20.3 months) (P = 0.0134). In agreement with those findings, RABL6A expression was increased in pancreatic cancer cell lines compared to normal pancreatic epithelial cells, and its knockdown inhibited pancreatic cancer cell proliferation and induced apoptosis. Moreover, RABL6A depletion selectively sensitized cells to oxaliplatin-induced arrest and death. This work reveals that RABL6A promotes the proliferation, survival, and oxaliplatin resistance of PDAC cells, whereas its loss is associated with extended survival in patients with resected PDAC. Such data suggest RABL6A is a novel biomarker of PDAC and potential target for anticancer therapy. © The Author(s) 2013.

关键词： ARF chemoresistance oxaliplatin pancreatic ductal adenocarcinoma RABL6A

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