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Perioperative Stress, Inflammation, and Cancer Progression: Opportunities for Intervention in Breast and Colorectal Cancer Surgery Utilizing Beta-Adrenergic Blockade and COX-2 Inhibition

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Current Anesthesiology Reports 2018年第4期8卷 386-392页

作者： Fischer, Avital Ben-Eliyahu, Shamgar School of Medicine Medical Scientist Training Program University of California Irvine Irvine CA United States Sagol School of Neuroscience School of Psychological Sciences Tel Aviv University Tel Aviv 69978 Israel

Purpose of review: This review explores the blockade of cyclooxygenase (COX)-2/prostaglandin and catecholamine/beta(β)-adrenergic signaling as opportunities to enhance the curative potential of surgical excision of breast and colorectal cancer malignancies. Recent findings: Phase-II randomized placebo-controlled biomarker clinical trials, employing perioperative administration of the COX-2 inhibitor etodolac and the β-adrenergic antagonist propranolol, have shown improved biomarkers associated with both breast and colorectal cancer progression. Tumor epithelial-to-mesenchymal transition (EMT) status and tumor transcription activity levels of GATA-1, GATA-2, EGR3, and STAT-3 were reduced, while anti-cancer immune parameters within the tumor microenvironment improved perioperatively. Increased tumor-associated B cells and NK cells and reduced tumor-associated monocytes were noted. Reduced systemic pro-inflammatory markers IL-6 and CRP were indicated, starting before surgery. Summary: Improved biomarkers of tumor-associated (i) anti-metastatic transcriptional activity, (ii) anti-metastatic immune function, and (iii) reduced systemic inflammatory indices were observed following the combined administration of etodolac and propranolol. These findings support future investigation with larger clinical trials to test long-term cancer outcomes. © 2018, Springer Science+Business Media, LLC, part of Springer Nature.

关键词： Beta-adrenergic blockade Breast cancer Cancer progression Colorectal cancer COX-2 inhibition Perioperative stress Surgery

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Real-World Experiences With Yoga on Cancer-Related Symptoms in Women With Breast Cancer

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Global Advances In Health and Medicine 2021年第1期10卷

作者： Patel, Shruti R Zayas, Jacqueline Medina-Inojosa, Jose R Loprinzi, Charles Cathcart-Rake, Elizabeth J Bhagra, Anjali Olson, Janet E Couch, Fergus J Ruddy, Kathryn J Department of Internal Medicine Mayo Clinic Rochester MN United States Mayo Clinic Graduate School of Biomedical Sciences Mayo Clinic School of Medicine and the Mayo Clinic Medical Scientist Training Program Rochester MN United States Department of Cardiovascular Medicine Mayo Clinic Rochester MN United States Department of Medical Oncology Mayo Clinic Rochester MN United States Department of Medical Oncology University of Missouri Kansas City MO United States Department of Health Sciences Research Mayo Clinic Rochester MN United States Department of Laboratory Medicine and Pathology Mayo Clinic Rochester MN United States

Purpose: Integrative therapies such as yoga are potential treatments for many psychological and physical symptoms that occur during and/or after treatment for cancer. The purpose of the current study was to evaluate the patient-perceived benefit of yoga for symptoms commonly experienced by breast cancer survivors. Methods: 1,049 breast cancer survivors who had self-reported use of yoga on a follow up survey, in an ongoing prospective Mayo Clinic Breast Disease Registry (MCBDR), received an additional mailed yoga-focused survey asking about the impact of yoga on a variety of symptoms. Differences between pre- and post- scores were assessed using Wilcoxon Signed Rank Test. Results: 802/1,049 (76%) of women who were approached to participate, consented and returned the survey. 507/802 (63%) reported use of yoga during and/or after their cancer diagnosis. The vast majority of respondents (89.4%) reported some symptomatic benefit from yoga. The most common symptoms that prompted the use of yoga were breast/chest wall pain, lymphedema, and anxiety. Only 9% of patients reported that they had been referred to yoga by a medical professional. While the greatest symptom improvement was reported with breast/chest wall pain and anxiety, significant improvement was also perceived in joint pain, muscle pain, fatigue, headache, quality of life, hot flashes, nausea/vomiting, depression, insomnia, lymphedema, and peripheral neuropathy, (all p-values <0.004). Conclusion: Data supporting the use of yoga for symptom management after cancer are limited and typically focus on mental health. In this study, users of yoga often reported physical benefits as well as mental health benefits. Further prospective studies investigating the efficacy of yoga in survivorship are warranted. © The Author(s) 2021.

关键词： breast cancer complementary and alternative medicine survivorship symptom control yoga

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Common AAV gene therapy vectors show nonselective transduction of ex vivo human brain tissue

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Molecular Therapy Methods & Clinical Development 2025年第2期33卷

作者： JP McGinnis Joshua Ortiz-Guzman Maria Camila Guevara Sai Mallannagari Benjamin D.W. Belfort Suyang Bao Snigdha Srivastava Maria Morkas Emily Ji Angela Addison Evelyne K. Tantry Sarah Chen Ying Wang Zihong Chen Kalman A. Katlowitz Jeffrey J. Lange Melissa M. Blessing Carrie A. Mohila M. Cecilia Ljungberg Guillermo Aldave Benjamin R. Arenkiel Department of Neurosurgery Baylor College of Medicine Houston TX 77030 USA Jan and Dan Duncan Neurological Research Institute Texas Children’s Hospital Houston TX 77030 USA Department of Molecular and Human Genetics Baylor College of Medicine Houston TX 77030 USA Medical Scientist Training Program Baylor College of Medicine Houston TX 77030 USA Development Disease Models & Therapeutics Graduate Program Baylor College of Medicine Houston TX 77030 USA Stowers Institute for Medical Research Kansas City MO 64110 USA Department of Pathology Texas Children’s Hospital Baylor College of Medicine Houston TX 77030 USA Department of Pediatrics Texas Children’s Hospital Baylor College of Medicine Houston TX 77030 USA Department of Neurosurgery Texas Children’s Hospital Baylor College of Medicine Houston TX 77030 USA

The ability to deliver a therapeutic sequence to a specific cell type in the human brain would make possible innumerable therapeutic options for some of our most challenging diseases; however, studies on adeno-associated virus (AAV) vector tropism have generally relied on animal models with limited translational utility. For this reason, establishing the tropism of common adeno-associated virus (AAV) vectors in living human brain tissue serves as an important baseline for further optimization, as well as a determination of human brain cell types transduced by clinically approved gene therapy vectors AAV2 and AAV9. We have adapted an ex vivo organotypic model to evaluate AAV transduction properties in living slices of human brain tissue. Using fluorescent reporter expression and single-nucleus RNA sequencing, we found that common AAV vectors show broad transduction of normal cell types, with protein expression most apparent in astrocytes; this work introduces a pipeline for identifying and optimizing AAV gene therapy vectors in human brain samples.

关键词： gene therapy human brain AAV AAV tropism human brain organotypic slice culture

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A consensus protocol for functional connectivity analysis in the rat brain (vol 26, pg 673, 2023)

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NATURE neuroscience 2023年第6期26卷 1127-1128页

作者： Grandjean, Joanes Desrosiers-Gregoire, Gabriel Anckaerts, Cynthia Angeles-Valdez, Diego Ayad, Fadi Barriere, David A. Blockx, Ines Bortel, Aleksandra Broadwater, Margaret Cardoso, Beatriz M. Celestine, Marina Chavez-Negrete, Jorge E. Choi, Sangcheon Christiaen, Emma Clavijo, Perrin Colon-Perez, Luis Cramer, Samuel Daniele, Tolomeo Dempsey, Elaine Diao, Yujian Doelemeyer, Arno Dopfel, David Dvorakova, Lenka Falfan-Melgoza, Claudia Fernandes, Francisca F. Fowler, Caitlin F. Fuentes-Ibanez, Antonio Garin, Clement M. Gelderman, Eveline Golden, Carla E. M. Guo, Chao C. G. Henckens, Marloes J. A. G. Hennessy, Lauren A. Herman, Peter Hofwijks, Nita Horien, Corey Ionescu, Tudor M. Jones, Jolyon Kaesser, Johannes Kim, Eugene Lambers, Henriette Lazari, Alberto Lee, Sung-Ho Lillywhite, Amanda Liu, Yikang Liu, Yanyan Y. Lopez-Castro, Alejandra Lopez-Gil, Xavier Ma, Zilu MacNicol, Eilidh Madularu, Dan Mandino, Francesca Marciano, Sabina McAuslan, Matthew J. McCunn, Patrick McIntosh, Alison Meng, Xianzong Meyer-Baese, Lisa Missault, Stephan Moro, Federico Naessens, Daphne M. P. Nava-Gomez, Laura J. Nonaka, Hiroi Ortiz, Juan J. Paasonen, Jaakko Peeters, Lore M. Pereira, Mickael Perez, Pablo D. Pompilus, Marjory Prior, Malcolm Rakhmatullin, Rustam Reimann, Henning M. Reinwald, Jonathan Del Rio, Rodrigo Triana Rivera-Olvera, Alejandro Ruiz-Perez, Daniel Russo, Gabriele Rutten, Tobias J. Ryoke, Rie Sack, Markus Salvan, Piergiorgio Sanganahalli, Basavaraju G. Schroeter, Aileen Seewoo, Bhedita J. Selingue, Erwan Seuwen, Aline Shi, Bowen Sirmpilatze, Nikoloz Smith, Joanna A. B. Smith, Corrie Sobczak, Filip Stenroos, Petteri J. Straathof, Milou Strobelt, Sandra Sumiyoshi, Akira Takahashi, Kengo Torres-Garcia, Maria E. Tudela, Raul van den Berg, Monica van der Marel, Kajo van Hout, Aran T. B. Vertullo, Roberta Vidal, Benjamin Vrooman, Roel M. Wang, Victora X. Wank, Isabel Watson, David J. G. Yin, Ting Zhang, Yongzhi Zurbruegg, Stefan Achard, Sophie Alcauter, Sarael Auer, Dorothee P. Barbier, Emmanuel L. Baudewig, Juergen Beckmann, Chri Donders Institute for Brain Behaviour and Cognition Radboud University Nijmegen The Netherlands Department for Medical Imaging Radboud University Medical Center Nijmegen The Netherlands Cerebral Imaging Centre Douglas Mental Health University Institute Verdun QC Canada Integrated Program in Neuroscience McGill University Montreal QC Canada Bio-imaging Lab University of Antwerp Antwerp Belgium µNEURO Research Centre of Excellence University of Antwerp Antwerp Belgium Instituto de Neurobiología Universidad Nacional Autónoma de México Campus Juriquilla Querétaro Mexico Biological and Biomedical Engineering McGill University Montreal QC Canada McConnell Brain Imaging Centre McGill University Montreal QC Canada Montreal Neurological Institute McGill University Montreal QC Canada UMR INRAE/CNRS 7247 Physiologie des Comportements et de la Reproduction Physiologie de la reproduction et des comportements Centre de recherche INRAE de Nouzilly Tours France Department of Neurology and Neurosurgery McGill University Montreal QC Canada Center for Animal MRI University of North Carolina at Chapel Hill Chapel Hill NC USA Department of Neurology University of North Carolina at Chapel Hill Chapel Hill NC USA Biomedical Research Imaging Center University of North Carolina at Chapel Hill Chapel Hill NC USA Preclinical MRI Champalimaud Research Champalimaud Centre for the Unknown Lisbon Portugal Laboratoire des Maladies Neurodégénératives Molecular Imaging Research Center (MIRCen) Université Paris-Saclay Commissariat à l’Énergie Atomique et aux Énergies Alternatives (CEA) CNRS Fontenay-aux-Roses France Departamento de Neurobiología Conductual y Cognitiva Instituto de Neurobiología Universidad Nacional Autónoma de México Campus Juriquilla Querétaro México Translational Neuroimaging and Neural Control Group High-Field Magnetic Resonance Max Planck Institute for Biological Cybernetics Tuebingen Germany Graduate Training Centre of Neuroscience International Max

Task-free functional connectivity in animal models provides an experimental framework to examine connectivity phenomena under controlled conditions and allows for comparisons with data modalities collected under invasive or terminal procedures. Currently, animal acquisitions are performed with varying protocols and analyses that hamper result comparison and integration. Here we introduce StandardRat, a consensus rat functional magnetic resonance imaging acquisition protocol tested across 20 centers. To develop this protocol with optimized acquisition and processing parameters, we initially aggregated 65 functional imaging datasets acquired from rats across 46 centers. We developed a reproducible pipeline for analyzing rat data acquired with diverse protocols and determined experimental and processing parameters associated with the robust detection of functional connectivity across centers. We show that the standardized protocol enhances biologically plausible functional connectivity patterns relative to previous acquisitions. The protocol and processing pipeline described here is openly shared with the neuroimaging community to promote interoperability and cooperation toward tackling the most important challenges in neuroscience.

关键词： Databases Neural circuits

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A Cell-Free Antigen Processing System Reveals Factors Critical for HIV-1 Epitope Dominance and Informs Vaccine Design

SSRN

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SSRN 2021年

作者： Sengupta, Srona Reed, Madison C. Yu, Jeanna Zhang, Josephine Kim, Aeryon Boronina, Tatiana N. Welsh, Robin A. Yang, Weiming Timmons, Andrew E. Wrabl, James O. Hoh, Rebecca Cole, Robert N. Deeks, Steve Siliciano, Janet D. Siliciano, Robert F. Sadegh-Nasseri, Scheherazade Department of Medicine Johns Hopkins University School of Medicine BaltimoreMD21205 United States Department of Pathology Johns Hopkins University School of Medicine BaltimoreMD21205 United States Department of Inflammation and Oncology Genome Analysis Unit Amgen Research Amgen Inc. South San FranciscoCA94080 United States Mass Spectrometry and Proteomics Facility Department of Biological Chemistry Johns Hopkins University School of Medicine BaltimoreMD21205 United States Department of Biology Johns Hopkins University BaltimoreMD21218 United States Department of Medicine University of California San Francisco San FranciscoCA94143 United States Howard Hughes Medical Institute BaltimoreMD21205 United States The Graduate Program in Immunology Medical Scientist Training Program Johns Hopkins University School of Medicine BaltimoreMD21205 United States

Distinct CD4+T cell epitopes have been associated with spontaneous control of HIV-1 replication, but analysis of antigen-dependent factors that influence epitope selection is lacking. To examine these factors, we used a cell-free antigen processing system that incorporates soluble HLA-DR (DR1), HLA-DM (DM), and cathepsins along with full-length protein antigens for epitope identification by LC-MS/MS. HIV-1 Gag, Pol, Env, Vif, Nef, Tat, and Rev were examined using this system. We identified 35 novel epitopes, including glycopeptides. Epitopes from smaller HIV-1 proteins with crystal structures mapped to regions of low protein stability and higher solvent accessibility. HIV-1 antigens associated with limited CD4+T cell responses were processed efficiently, while some protective epitopes were inefficiently processed. 66% of epitopes obtained from cell-free processing induced memory CD4+T cell responses in HIV-1+ donors, including 10 of 19 novel epitopes. Thus, an in vitro processing system can identify novel HIV-1 epitopes and reveal factors influencing epitope dominance. © 2021, The Authors. All rights reserved.

关键词： Epitopes

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Therapeutic Targeting of Follicular T Cells with Chimeric Antigen Receptor-Expressing Natural Killer Cells (vol 1, pg 100003, 2020)

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CELL REPORTS MEDICINE 2020年第5期1卷 100003-100003页

作者： Reighard, Seth D. Cranert, Stacey A. Rangel, Kelly M. Ali, Ayad Gyurova, Ivayla E. de la Cruz-Lynch, Arthur T. Tuazon, Jasmine A. Khodoun, Marat V. Kottyan, Leah C. Smith, David F. Brunner, Hermine I. Waggoner, Stephen N. Center for Autoimmune Genomics and Etiology Cincinnati Children’s Hospital Medical Center Cincinnati OH 45229 USA Medical Scientist Training Program University of Cincinnati College of Medicine Cincinnati OH 45267 USA Immunology Graduate Training Program University of Cincinnati College of Medicine Cincinnati OH 45267 USA Division of Developmental Biology Cincinnati Children’s Hospital Medical Center Cincinnati OH 45229 USA Pathobiology and Molecular Medicine Graduate Program University of Cincinnati College of Medicine Cincinnati OH 45267 USA Division of Immunology Allergy and Rheumatology Department of Medicine University of Cincinnati Medical Center Cincinnati OH 45267 USA Department of Research Cincinnati Veterans Affairs Medical Center Cincinnati OH 45220 USA Department of Pediatrics University of Cincinnati College of Medicine Cincinnati OH 45267 USA Division of Pediatric Otolaryngology - Head & Neck Surgery Cincinnati Children’s Hospital Medical Center Cincinnati OH 45229 USA Division of Pulmonary and Sleep Medicine Cincinnati Children’s Hospital Medical Center Cincinnati OH 45229 USA Department of Otolaryngology - Head & Neck Surgery University of Cincinnati College of Medicine Cincinnati OH 45267 USA Division of Rheumatology Cincinnati Children’s Hospital Medical Center Cincinnati OH 45229 USA

Follicular helper T cells (TFH) are critical for vaccine and infection elicitation of long-lived humoral immunity, but exaggerated TFH responses can promote autoimmunity and other pathologies. It is unfortunate that no clinical interventions exist for the selective depletion of follicular T cells to alleviate these diseases. We engineered a chimeric antigen receptor (CAR) facilitating the specific targeting of cells with high expression levels of human programmed cell death protein 1 (PD-1), a cardinal feature of follicular T cells. CAR-expressing human natural killer (NK) cells robustly and discriminately eliminated PD-1high follicular human T cells in vitro and in a humanized mouse model of lupus-like disease while sparing B cells and other PD-1low T cell subsets, including regulatory T cells. These results establish a strategy for specific targeting of PD-1high T cells that can be advanced as a clinical tool for the selective depletion of pathogenic follicular T cells or other PD-1high target cells in certain disease states.

关键词： systemic lupus erythematosus rheumatoid arthritis Sjögren syndrome allergy cytotherapy cytotoxicity checkpoint PD-L1 NK-92

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Publisher Correction: Multistate and functional protein design using RoseTTAFold sequence space diffusion

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Nature biotechnology 2024年 2024 Oct 7页

作者： Sidney Lyayuga Lisanza Jacob Merle Gershon Samuel W K Tipps Jeremiah Nelson Sims Lucas Arnoldt Samuel J Hendel Miriam K Simma Ge Liu Muna Yase Hongwei Wu Claire D Tharp Xinting Li Alex Kang Evans Brackenbrough Asim K Bera Stacey Gerben Bruce J Wittmann Andrew C McShan David Baker Department of Biochemistry University of Washington Seattle WA USA. Institute for Protein Design University of Washington Seattle WA USA. Graduate Program in Biological Physics Structure and Design University of Washington Seattle WA USA. Department of Molecular Engineering University of Washington Seattle WA USA. Molecular & Cellular Biology Medical Scientist Training Program University of Washington Seattle WA USA. Faculty of Engineering Sciences Heidelberg University Heidelberg Germany. School of Chemistry and Biochemistry Georgia Institute of Technology Atlanta GA USA. Office of the Chief Scientific Officer Microsoft Redmond WA USA. Department of Biochemistry University of Washington Seattle WA USA. dabaker@uw.edu. Institute for Protein Design University of Washington Seattle WA USA. dabaker@uw.edu. Howard Hughes Medical Institute University of Washington Seattle WA USA. dabaker@uw.edu.

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BIOM-25. IDENTIFYING EXTRACELLULAR VESICLES FROM GLIOBLASTOMA OR NON-NEOPLASTIC CELLS VIA IMAGING FLOW CYTOMETRY

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Neuro-Oncology 2020年第SUPPLEMENT_2期22卷 ii7-ii7页

作者： Milbeth Cumba Garcia, Luz Aibaidula, Abudumijiti Kazemi, Nazanin Yeganeh Jung, Miyeon Lucien-Matteoni, Fabrice Markovic, Svetomir Parney, Ian Mayo Clinic Graduate School of Biomedical Sciences Rochester MN USA Mayo Clinic Medical Scientist Training Program Rochester MN USA Mayo Clinic Rochester MN USA

Patients with glioblastoma (GBM) have a median survival of 15 months despite aggressive treatment. Immunosuppressive monocytes are heavily infiltrated in these tumors and in patients’ circulation. Treatment-related pseudo-progression confounds outcome assessment by MRI. Thus, there is a need for additional non-invasive methods to assess treatment response. Extracellular vesicles (EVs) contain tumor-specific microRNA (miRNA) cargo that could serve as a liquid biopsy to distinguish true progression from treatment-related pseudo-progression. We had found significant differences in plasma EVs molecular profile (i.e. miRNA signatures) between GBM patients and healthy donors. Our overall hypothesis is that these differences reflect the EVs cell of origin. Our goal in this project was to develop a fluorescent staining paradigm by flow cytometry to distinguish EVs from different cellsin vitroand determine differences in EV miRNA expression profile between GBM and monocytic cell-derived EVs. Gleolan (5-ALA) is an FDA-approved orally available agent for fluorescence-guided resection of GBM tumors. It is metabolized to protoporphyrin IX (PpIX) in GBM cells but not in non-neoplastic cells and has been reported to aid in the detection of GBM-derived EVs by flow cytometry. However, distinguishing between GBM-derived EVs and EVs from other cells of origin has not been described. We co-cultured human GBM cells (dBT114 or dBT116) and CD14+ monocytes for 72 hours in the presence or absence of 5-ALA. EVs were isolated by ultracentrifugation and stained for CD11b (myeloid cell marker). ImageStream Imaging Flow Cytometry was performed showing clear differentiation between PpIX+ EVs from GBM cells and CD11b+ EVs from monocytes. Interestingly, a small number of double-positive EVs (presumably representing monocyte-derived EVs that had taken up PpIX after phagocytizing GBM cells) were also present. Taken together, we were able to optimize a technique to distinguish EVs originating from GBM

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DIPG-58. Therapeutic HDAC targeting in hypermutant CNS tumors

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Neuro-Oncology 2022年第SUPPLEMENT_1期24卷 i32-i32页

作者： Myers, Carrie Noll, Alyssa Biery, Matthew Meechan, Michael Tahiri, Sophie Foster, Jessica Dun, Matthew Olson, James Vitanza, Nicholas The Ben Towne Center for Childhood Cancer Research Seattle Children’s Research Institute Seattle WA USA Molecular and Cellular Biology Graduate Program and Medical Scientist Training Program University of Washington Seattle Washington USA Division of Oncology The Children's Hospital of Philadelphia Philadelphia PA USA Department of Pediatrics Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Cancer Signaling Research Group School of Biomedical Sciences and Pharmacy College of Health Medicine and Wellbeing University of Newcastle Callaghan NSW Australia Individualised Medicine Program Hunter Medical Research Institute New Lambton Heights NSW Australia Division of Pediatric Hematology Oncology Bone Marrow Transplant and Cellular Therapy Department of Pediatrics Seattle Children’s Hospital University of Washington Seattle WA USA

Diffuse intrinsic pontine glioma (DIPG) is a universally fatal tumor of the pons, most often characterized by mutations in genes encoding histone 3, that led to the classification diffuse midline glioma, H3 K27M-mutant (DMG). However, 15% of DIPG are histone wildtype (H3WT) and can have a hypermutant phenotype, characterized by mutations in DNA mismatch repair that also occur in pediatric high-grade glioma (pHGG). We previously published the preclinical efficacy of quisinostat in DMG. As hypermutant CNS tumors share transcriptional disruption with DMG, we investigated if HDAC inhibition was also therapeutic against hypermutant DIPG and pHGG. We tested PBT-24, a PMS2 mutant, treatment-naïve, patient-derived hypermutant DIPG model, and found similar quisinostat sensitivity compared to other DMG cultures in vitro (IC50 = ~30 nM), as well as significant efficacy in a xenograft flank model (60 day mean tumor size of 1109mm3 [vehicle] vs. 19mm3 [quisinostat-treated]). This in vivo effect was greater than the anti-tumor effect observed in a xenograft flank non-hypermutant DMG model PBT-09 (60 day mean tumor size of 1006mm3 [vehicle] vs. 244mm3 [quisinostat-treated]). To validate the effect of hypermutation on sensitivity to quisinostat, we generated PMS2 knock-out (KO) and MSH2 KO isogenic cell lines using the H3WT model VUMC-DIPG-10. In a xenograft flank model, we observed increased quisinostat sensitivity in the KO models (20 day mean tumor volume of 547mm3 [parental], 396mm3 [PMS2 KO], and 150mm3 [MSH2 KO]). RNA sequencing of quisinostat-treated PBT-24 revealed an increase in acute inflammatory response genes which we are investigating as a mechanism of action for HDACi against hypermutant tumors. Ultimately, we demonstrate the in vivo efficacy of quisinostat against hypermutant DIPG that supports the investigation of HDAC inhibition as a treatment strategy across hypermutant CNS tumors.

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Author Correction: A spatial genome aligner for resolving chromatin architectures from multiplexed DNA FISH

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Nature biotechnology 2023年第7期41卷 1027页

作者： Bojing Blair Jia Adam Jussila Colin Kern Quan Zhu Bing Ren Bioinformatics and Systems Biology Graduate Program University of California San Diego La Jolla CA USA. Medical Scientist Training Program University of California San Diego La Jolla CA USA. Department of Cellular and Molecular Medicine Center for Epigenomics University of California San Diego La Jolla CA USA. Department of Cellular and Molecular Medicine Center for Epigenomics University of California San Diego La Jolla CA USA. biren@health.ucsd.edu. Ludwig Institute for Cancer Research La Jolla CA USA. biren@health.ucsd.edu. Institute of Genomic Medicine Moores Cancer Center School of Medicine University of California San Diego La Jolla CA USA. biren@health.ucsd.edu.

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