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Assistive technology with device for self-inflating bag in neonatology

Research on Biomedical Engineering 2025年第2期41卷

作者： Marcelino, Ana Carolina Rodovanski, Giovana Pascoali Bonetti, Karoline Panes, Caio Rabinovich de Almeida Martins, Fernando Moran, Cristiane Aparecida Araranguá Brazil Graduate Program in Neurosciences and Behavior Department of Experimental Psychology of the Institute of Psychology-University of São Paulo Sao Paulo Brazil Araranguá Brazil Computer Engineering Instituto Mauá de Tecnologia São Caetano do Sul Brazil Electronic Engineering and Computing with Emphasis on Electronic Devices and Systems at Instituto Tecnológico de Aeronáutica–ITA São Caetano do Sul Brazil Department of Physiotheraphy and at the Postgraduate Program in Rehabilitation Science of the Federal University of Santa Catarina-UFCS Ararangua Brazil

Purpose: The objectives of this study were to create a device with technological development of the self-inflating bag (SIB) equipment to measure the variables tidal volume, peak inspiratory pressure, and inspiratory flow and to evaluate the knowledge of undergraduate students in handling the SIB. To reduce the risks of mortality, length of hospital stay, and infections, SIB is a resource used to ventilate the patient through the inflation of the device, but it is not capable of measuring the ventilatory parameters. Excess ventilation and incorrect handling of the bag can cause lung injury in newborns. Therefore, measuring these parameters can prevent lung injury resulting from inadequate ventilation. Method: This is a cross-sectional and experimental study, with the development of a device SIB that allows the evaluation of variables of neonatal respiratory mechanics that were tested with an artificial lung. It was approved by the Research Ethics Committee and the research was developed in three stages: the first represents the search for scientific articles for the consensus of neonatal ventilatory variables for the construction of the SIB parameters;the second stage depicts the technological development of a device capable of monitoring such variables through the SIB. In the third stage, the content validation of the device with the handling of the SIB was carried out by students of medicine and physiotherapy courses of Brazil. Results: In this work, a device that analyzes the values of the main ventilatory parameters in neonatology was developed and to generate a safety range for the use of the device, curves with a tolerance of 10% up and down were created. All electronic components were coupled to the equipment, with a display that transmits the parameter values. The web page can be used on a cell phone, tablet, computer, or SmartTv, as long as it is connected to the "RespiratorIoT_AP" network. Among the 29 participants in the study, 8 said they were familiar w

关键词： Students

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Multilayer recurrent network models of primate retinal ganglion cell responses 5

Multilayer recurrent network models of primate retinal gangl...

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5th International Conference on Learning Representations, ICLR 2017

作者： Batty, Eleanor Merel, Josh Brackbill, Nora Heitman, Alexander Sher, Alexander Litke, Alan Chichilnisky, E.J. Paninski, Liam Doctoral Program in Neurobiology and Behavior Columbia University United States Department of Physics Stanford University United States Neurosciences Graduate Program University of California San Diego United States Santa Cruz Institute for Particle Physics University of California Santa Cruz United States Department of Neurosurgery Hansen Experimental Physics Laboratory Stanford University United States Departments of Statistics and Neuroscience Columbia University United States

Developing accurate predictive models of sensory neurons is vital to understanding sensory processing and brain computations. The current standard approach to modeling neurons is to start with simple models and to incrementally add interpretable features. An alternative approach is to start with a more complex model that captures responses accurately, and then probe the fitted model structure to understand the neural computations. Here, we show that a multitask recurrent neural network (RNN) framework provides the flexibility necessary to model complex computations of neurons that cannot be captured by previous methods. Specifically, multilayer recurrent neural networks that share features across neurons outperform generalized linear models (GLMs) in predicting the spiking responses of parasol ganglion cells in the primate retina to natural images. The networks achieve good predictive performance given surprisingly small amounts of experimental training data. Additionally, we present a novel GLM-RNN hybrid model with separate spatial and temporal processing components which provides insights into the aspects of retinal processing better captured by the recurrent neural networks. © ICLR 2019 - Conference Track Proceedings. All rights reserved.

关键词： Neurons

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Balancing Cortisol: The Role of Affect-adjusted and Multimodal Exercise as an Adjunct to Pharmacotherapy in a Randomized Controlled Trial for Major Depressive Disorder

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Mental Health and Physical Activity 2025年

作者： Vagner Deuel de O. Tavares Geovan Menezes de Sousa Felipe B. Schuch Joseph Firth Lin Yang Maria Stein Bruno Marson Malagodi Raissa Nóbrega Renali Camilo Bezerra Alexandre Guimarães Gouveia Jaime Eduardo Hallak Emerson Arcoverde Colleen Cuthbert Nicole Leite Galvão-Coelho Laboratory of Hormone Measurement Department of Physiology and Behavior Federal University of Rio Grande do Norte Natal Brazil Graduate Program in Psychobiology Center for Biosciences Federal University of Rio Grande do Norte Natal Brazil Department of Community Health Sciences University of Calgary Faculty of Nursing University of Calgary Calgary AB Canada Department of Sports Methods and Techniques Federal University of Santa Maria Santa Maria Brazil Institute of Psychiatry Federal University of Rio de Janeiro Rio de Janeiro Brazil Faculty of Health Sciences Universidad Autónoma de Chile Providencia Chile Division of Psychology and Mental Health University of Manchester Manchester Academic Health Science Centre Manchester UK Department of Cancer Epidemiology and Prevention Research Cancer Care Alberta Alberta Health Services Calgary Canada Department of Oncology Cumming School of Medicine University of Calgary Calgary AB Canada Department of Clinical Psychology and Psychotherapy Institute of Psychology University of Bern Bern Switzerland Department of Sport Sciences State University of Londrina Londrina Paraná Brazil Neurosciences and Behavior Department Ribeirao Preto Medical School University of Sao Paulo Brazil Onofre Lopes University Hospital Federal University of Rio Grande do Norte Natal Brazil National Institute of Science and Technology for Translational Medicine – INCT TM – CNPq/FAPESP/CAPES Brazil NICM Health Research Institute Western Sydney University Westmead New South Wales

Background The adjunctive effects of exercise on cortisol levels in people with major depressive disorders (MDD) are equivocal. Therefore, we aimed to compare pharmacotherapy alone (antidepressants) versus an adjunct intervention of pharmacotherapy plus exercise on cortisol levels over 12 weeks. Methods Serum cortisol were assessed before (baseline–t0), during (Week 5–t1), and end of treatment (Week 12–t2). The exercise intervention focused on promoting perceived effort, enjoyment, and overall pleasure throughout multimodal exercise sessions. The study enrolled 59 adults and randomly allocated them into two groups: exercise group (EG; n=26,76.9% females, mean age 28.5 years; normal cortisol- EG-CN, n=18 and hypercortisolemia- EG-HC,n=7) and control group (CG, n=29,72.40% females, mean age 26.0 years/normal cortisol CO-CN,n=17 and hypercortisolemia- CO-HC,n=11). Results No changes in cortisol levels were observed over time in either groups (EG and CO). However, in subgroup analysis, participants with hypercortisolemia reduced their cortisol levels regardless of the intervention allocation. At the end of the study, hypercortisolemic MDD participants of EG showed similar cortisol levels with those of the normal cortisol group (EG-CN) [p=.507,d=-.22(-1.11,.67)], while hypercortisolemic MDD participants under exclusive pharmacotherapy (control group) continued to show significantly higher levels than CO-CN [p=<.0001,d=-2.32(-3.41,-1.20)]. Conclusion Our preliminary findings suggest that, in people with MDD and hypercortisolemia, a structured, multimodal, affect-adjusted, and supervised exercise program along with pharmacotherapy normalized cortisol levels. Notwithstanding, neither pharmacotherapy nor exercise plus pharmacotherapy changed cortisol levels among those with normal cortisol levels at baseline. These results indicate that combining exercise with pharmacotherapy may be effective in reducing cortisol levels specifically in individuals with MDD and elevated corti

关键词： Multimodal exercise Pharmacotherapy Cortisol Major Depression

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Influence of maternal bipolar disorder on the biological rhythms of their offspring

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Psychiatry Research Communications 2022年第1期2卷

作者： de Souza Berny, Thierry Patel, Swara de Azevedo Cardoso, Taiane Dias de Mattos Souza, Luciano Reyes, Amanda Neumann Fialho, Amanda Rodrigues Sampaio Jansen, Kimberli Tiane Mondin, Thaíse Azevedo da Silva, Ricardo Jansen, Karen Health and Behavior Graduate Program Catholic University of Pelotas Rio Grande do Sul Pelotas Brazil School of Interdisciplinary Science Life Sciences Program McMaster University Hamilton Ontario Canada Department of Psychiatry and Behavioural Neurosciences McMaster University Hamilton Ontario Canada Pró-Reitoria de Assuntos Estudantis (PRAE) Federal University of Pelotas Rio Grande do Sul Pelotas Brazil

This study aimed to assess the association between maternal diagnosis of Bipolar Disorder (BD) and the biological rhythms of their offspring, and describe the synchronization of biological rhythms among mothers and their offspring. This study included 59 mothers with a diagnosis of BD and 59 mothers who have not been diagnosed with BD at the first stage of the study, as well as their offspring aged 9–11 years. The mothers' biological rhythms were assessed using the Biological Rhythm Interview of Assessment in Neuropsychiatry (BRIAN) and the offspring's biological rhythms were evaluated using the same assessment tool in the kids' version. The offspring of mothers with BD showed a significantly higher disruption of overall biological rhythm when compared to the offspring of mothers without BD. The mothers with BD and their offspring showed a higher disruption of biological rhythms in all the BRIAN/BRIAN-k domains when compared to the mothers without BD and their offspring. Additionally, we identified a positive correlation between the disruption of biological rhythms in mothers and the disruption of biological rhythms in their offspring. It is likely that they synced their own rhythm with the disrupted rhythm of their mothers. © 2021 The Authors

关键词： Bipolar disorder offspring Circadian rhythm Sleep patterns

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Computer Vision and Eyetracking Approach for Assessing Visual Disorders in Premature Infants

Computer Vision and Eyetracking Approach for Assessing Visua...

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Annual IEEE Symposium on Computer-Based Medical Systems

作者： Rodrigo Ferraz Souza Manoella Rockembach Bruna Samantha Marchi Marcelo Fernandes Costa Cristiane Aparecida Moran Antonio Carlos Sobieranski Department of Computing - DEC Federal University of Santa Catarina Araranguá Brazil Department of Health Sciences Federal University of Santa Catarina Araranguá Brazil Neurosciences and Behavior Postgrad. Program Institute of Psychology São Paulo University São Paulo Brazil Department of Rehabilitation Sciences Federal University of Santa Catarina Araranguá Brazil Department of Computing - DEC Graduate Program in Information and Communication Technologies - PPGTIC Federal University of Santa Catarina Araranguá Brazil

ISBN: (数字)9798350384727

ISBN: (纸本)9798350384734

Premature infants are subjected to an elevated risk of abnormal visual development, leading to potential visual impairments such as field defects, optic nerve dysfunctions, eye movement abnormalities, and nystagmus. To mitigate these dangers, early and exact assessment is important. This paper presents a computer vision approach that uses face mapping and eye-tracking technologies to objectively and accurately assess further visual disorders in infants. Our methodology integrates eye-tracking with facial recognition techniques to quantify eye movements and gaze stability accurately. Detailed video recordings of infants responses to visual stimuli are analyzed using a custom-developed algorithm, which processes eye and head movements to generate precise metrics of visual function. The results demonstrate that our computational tool significantly enhances the diagnostic capabilities by providing quantifiable and objective metrics that supports the clinical observations, thus assisting healthcare professionals in identifying and addressing potential visual abnormalities at early stages effectively.

关键词： Measurement Visualization Pediatrics Computer vision Face recognition Visual impairment Gaze tracking

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Personality disorders as predictors for the conversion from major depressive disorder to bipolar disorder: A prospective cohort study

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Psychiatry Research Communications 2022年第3期2卷

作者： Bartz de Ávila, Gisele Montezano, Bruno Braga Dias de Mattos Souza, Luciano de Azevedo Cardoso, Taiane Azevedo da Silva, Ricardo Mondin, Thaíse Campos Moreira, Fernanda Pedrotti Jansen, Karen Department of Health and Behavior Catholic University of Pelotas RS Pelotas Brazil Graduate Program in Psychiatry and Behavioral Sciences Universidade Federal do Rio Grande do Sul RS Porto Alegre Brazil Molecular Psychiatry Laboratory Hospital de Clínicas de Porto Alegre RS Porto Alegre Brazil Mood Disorders Program Department of Psychiatry and Behavioural Neurosciences McMaster University Hamilton ON Canada Department of Student Affairs Federal University of Pelotas RS Pelotas Brazil

Studies suggest that personality disorders can predict mood disorders. The present study aims to assess whether personality traits in individuals with major depressive disorder (MDD) can predict the conversion to bipolar disorder (BD). This was a prospective cohort study conducted in two waves. In the first wave, 585 subjects were diagnosed with MDD;in the second wave, all of them were reevaluated in a three-year follow-up. Personality traits were evaluated, in the first phase, using the Millon Clinical Multiaxial Inventory (MCMI). MDD and BD diagnosis was performed by trained psychologists using a clinical structured interview based on diagnostics criteria of DSM IV, the Mini International Neuropsychiatric Interview, Plus version (MINI-PLUS). During the second wave, 468 individuals were reevaluated. Diagnostic conversion rate from MDD to BD was 12.4%. Higher mean scores in Antissocial, Borderline personality traits and in the sum of all Cluster B disorders were found among individuals who had converted to BD. In addition, individuals who converted to BD had lowest scores in obsessive-compulsive personality traits. Our findings suggest that Cluster B personality disorders can be considered as predictors of diagnostics conversion from MDD to BD. Also, it seems that obsessive-compulsive traits were lower among those individuals who have converted to BD. © 2022 The Authors

关键词： Bipolar disorder Cohort study Diagnostic conversion Major depressive disorder Personality disorders

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Publisher Correction: Tuned thalamic excitation is amplified by visual cortical circuits

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Nature neuroscience 2018年第9期21卷 1292页

作者： Anthony D Lien Massimo Scanziani Neurosciences Graduate Program University of California San Diego La Jolla California USA. anthony.d.lien@***. Center for Neural Circuits and Behavior Neurobiology Section and Department of Neuroscience University of California San Diego La Jolla California USA. anthony.d.lien@***. Howard Hughes Medical Institute University of California San Diego La Jolla California USA. anthony.d.lien@***. Neurosciences Graduate Program University of California San Diego La Jolla California USA. massimo@ucsd.edu. Center for Neural Circuits and Behavior Neurobiology Section and Department of Neuroscience University of California San Diego La Jolla California USA. massimo@ucsd.edu. Howard Hughes Medical Institute University of California San Diego La Jolla California USA. massimo@ucsd.edu.

In the published version of this article, a data point is missing from Fig. 4f, and the y-axis label reads "RF"; it should read "RF." The original article has not been corrected. The original and c...

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Publisher Correction: m1A in CAG repeat RNA binds to TDP-43 and induces neurodegeneration

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Nature 2024年 E16页

作者： Yuxiang Sun Hui Dai Xiaoxia Dai Xiaochuan Liu Feng Tang Yinsheng Wang Weifeng Gu Jiekai Yin Yuxiang Cui Gwendolyn Gonzalez Jun Yuan Nan Wang X. William Yang Alexandra E. Perlegos Nancy M. Bonini Department of Chemistry University of California Riverside Riverside CA USA Department of Molecular Cell and Systems Biology University of California Riverside Riverside CA USA Environmental Toxicology Graduate Program University of California Riverside Riverside CA USA Center for Neurobehavioral Genetics The Jane and Terry Semel Institute for Neuroscience and Human Behavior University of California Los Angeles Los Angeles CA USA Department of Psychiatry and Biobehavioral Sciences David Geffen School of Medicine University of California Los Angeles Los Angeles CA USA Neurosciences Graduate Group University of Pennsylvania Philadelphia PA USA Department of Biology University of Pennsylvania Philadelphia PA USA

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Identification and immunophenotype of abnormal cells present in focal cortical dysplasia type IIb

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Surgical and Experimental Pathology 2018年第1期1卷 1-10页

作者： Gleice K. Sousa Caroline S. Capitelli Thaís C. D. Dombroski César A. B. Zanella Antonio R. Martins Vera C. Terra Tonicarlo R. Velasco Americo C. Sakamoto Hélio R. Machado João A. Assirati Carlos G. Carlotti Vani M. Alves Jaderson Costa DaCosta André L. Palmini Eliseu Paglioli Roberto Spreafico Rita Garbelli Luciano Neder Laboratory of Neuroplasticity and Neuropeptides Graduate Programs in Physiological and Health Sciences Federal University of Triângulo Mineiro Uberaba MG ZIP 38.025-015 Brazil Present address: Centro Universitário de Varzea Grande Varzea Grande MT Brazil Department of Pharmacology Ribeirão Preto Medical School University of São Paulo Avenida Bandeirantes 3900 Ribeirão Preto SP 14049-900 Brazil Institute for Neurosciences and Behavior (INeC) Ribeirão Preto SP Brazil Epilepsy Surgery Center (CIREP) Hospital das Clínicas Ribeirão Preto Medical School University of São Paulo Avenida Bandeirantes 3900 Ribeirão Preto SP ZIP 14049-900 Brazil Present Address: Epicentro Hospital Nossa Sra. das Graças Curitiba PR Brazil Department of Neurology Ribeirão Preto Medical School University of São Paulo Avenida Bandeirantes 3900 Ribeirão Preto SP ZIP 14049-900 Brazil Department of Surgery Ribeirão Preto Medical School University of São Paulo Avenida Bandeirantes 3900 Ribeirão Preto SP ZIP 14049-900 Brazil Department of Cellular and Molecular Biology Ribeirão Preto Medical School University of São Paulo Avenida Bandeirantes 3900 Ribeirão Preto SP ZIP 14049-900 Brazil Department of Internal Medicine School of Medicine Epilepsy Surgery Program and Brain Institute Pontifícia Universidade Católica do Rio Grande do Sul Porto Alegre RS Brazil Department of Surgery School of Medicine Pontifícia Universidade Católica do Rio Grande do Sul Porto Alegre RS Brazil Clinical Epileptology and Experimental Neurophysiology Uni Fondazione IRCCS Istituto Neurologico “Carlo Besta” Milan Italy Department of Pathology Ribeirão Preto Medical School University of São Paulo Avenida Bandeirantes 3900 Ribeirão Preto SP ZIP 14049-900 Brazil

BackgroundFocal cortical dysplasias (FCDs) are malformations of cortical development that present cortical dyslamination and abnormal cell morphology and are frequently associated with refractory epilepsy. FCD type II... 详细信息

Background

Focal cortical dysplasias (FCDs) are malformations of cortical development that present cortical dyslamination and abnormal cell morphology and are frequently associated with refractory epilepsy. FCD type IIb presents dysmorphic neurons (DNs) and balloon cells (BCs), which are the hallmarks of this dysplasia. Moreover, hypertrophic neurons (HyNs) may be present in FCD types I, II and III. The objective of this study was to perform a detailed morphology and immunophenotype study of BCs, DNs, and HyNs in a cohort of FCD IIb patients.

Methods

Cortices resected as a treatment for refractory epilepsy from 18 cases of FCD type IIb were analysed using Bielschowsky method and haematoxylin and eosin as routine stains. Immunophenotype was performed using specific antibodies to detect epitopes differentially expressed by abnormal cells.

Results

All cases showed cortical dyslamination, BCs, DNs, and HyNs. No cell layer or column could be identified, except for cortical layer I. Lesions predominated in the frontal cortex (11 cases). DNs were large neurons and presented a clumped and or displaced Nissl substance towards the cell membrane, and a cytoplasm accumulation of neurofilament that displaced the nucleus to the cell periphery, as shown by Bielschowsky staining and immunohistochemistry. HyNs were as large as DNs, but without alterations of Nissl substance or dense neurofilament accumulation, with a central nucleus. BCs were identified as large, oval-shaped and pale eosinophilic cells, which lacked the Nissl substance, and presented an eccentric nucleus. BCs and DNs expressed epitopes of both undifferentiated and mature cells, detected using antibodies against nestin, vimentin, class III β-tubulin, pan-neuronal filaments, neurofilame

关键词： Focal cortical dysplasia type IIb Taylor’s focal cortical dysplasia Dysmorphic neuron Hypertrophic neuron Balloon cell Tuberous sclerosis complex Hemimegalencephaly

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Equivalency of the diagnostic accuracy of the PHQ-8 and PHQ-9: a systematic review and individual participant data meta-analysis (vol 50, pg 1368, 2020)

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PSYCHOLOGICAL MEDICINE 2020年第16期50卷 2816-2816页

作者： Wu, Yin Levis, Brooke Riehm, Kira E. Saadat, Nazanin Levis, Alexander W. Azar, Marleine Rice, Danielle B. Boruff, Jill Cuijpers, Pim Gilbody, Simon Ioannidis, John P. A. Kloda, Lorie A. McMillan, Dean Patten, Scott B. Shrier, Ian Ziegelstein, Roy C. Akena, Dickens H. Arroll, Bruce Ayalon, Liat Baradaran, Hamid R. Baron, Murray Bombardier, Charles H. Butterworth, Peter Carter, Gregory Chagas, Marcos H. Chan, Juliana C. N. Cholera, Rushina Conwell, Yeates de Manvan Ginkel, Janneke M. Fann, Jesse R. Fischer, Felix H. Fung, Daniel Gelaye, Bizu Goodyear-Smith, Felicity Greeno, Catherine G. Hall, Brian J. Harrison, Patricia A. Harter, Martin Hegerl, Ulrich Hides, Leanne Hobfoll, Stevan E. Hudson, Marie Hyphantis, Thomas Inagaki, Masatoshi Jette, Nathalie Khamseh, Mohammad E. Kiely, Kim M. Kwan, Yunxin Lamers, Femke Liu, Shen-Ing Lotrakul, Manote Loureiro, Sonia R. Lowe, Bernd McGuire, Anthony Mohd-Sidik, Sherina Munhoz, Tiago N. Muramatsu, Kumiko Osorio, Flavia L. Patel, Vikram Pence, Brian W. Persoons, Philippe Picardi, Angelo Reuter, Katrin Rooney, Alasdair G. Santos, Ina S. Shaaban, Juwita Sidebottom, Abbey Simning, Adam Stafford, Lesley Sung, Sharon Tan, Pei Lin Lynnette Turner, Alyna van Weert, Henk C. White, Jennifer Whooley, Mary A. Winkley, Kirsty Yamada, Mitsuhiko Benedetti, Andrea Thombs, Brett D. [a1]Lady Davis Institute for Medical Research Jewish General Hospital Montréal Québec Canada [a2]Department of Psychiatry McGill University Montréal Québec Canada [a3]Department of Epidemiology Biostatistics and Occupational Health McGill University Montréal Québec Canada [a4]Department of Psychology McGill University Montréal Québec Canada [a5]Schulich Library of Physical Sciences Life Sciences and Engineering McGill University Montreal Quebec Canada [a6]Department of Clinical Neuro and Developmental Psychology Amsterdam Public Health Research Institute Vrije Universiteit Amsterdam the Netherlands [a7]Hull York Medical School and the Department of Health Sciences University of York Heslington York UK [a8]Department of Medicine Department of Health Research and Policy Department of Biomedical Data Science Department of Statistics Stanford University Stanford California USA [a9]Library Concordia University Montréal Québec Canada [a10]Department of Community Health Sciences University of Calgary Calgary Alberta Canada [a11]Hotchkiss Brain Institute and O’Brien Institute for Public Health University of Calgary Calgary Alberta Canada [a12]Department of Medicine Johns Hopkins University School of Medicine Baltimore Maryland USA [a13]Department of Psychiatry Makerere University College of Health Sciences Kampala Uganda [a14]Department of General Practice and Primary Health Care University of Auckland Auckland New Zealand [a15]Louis and Gabi Weisfeld School of Social Work Bar Ilan University Ramat Gan Israel [a16]Endocrine Research Center Institute of Endocrinology and Metabolism Iran University of Medical Sciences Tehran Iran [a17]Ageing Clinical & Experimental Research Team Institute of Applied Health Sciences School of Medicine Medical Sciences and Nutrition University of Aberdeen Aberdeen Scotland UK [a18]Department of Medicine McGill University Montréal Québec Canada [a19]Department of Rehabilitation Medicine University of Washington S

BackgroundItem 9 of the Patient Health Questionnaire-9 (PHQ-9) queries about thoughts of death and self-harm, but not suicidality. Although it is sometimes used to assess suicide risk, most positive responses are not associated with suicidality. The PHQ-8, which omits Item 9, is thus increasingly used in research. We assessed equivalency of total score correlations and the diagnostic accuracy to detect major depression of the PHQ-8 and *** conducted an individual patient data meta-analysis. We fit bivariate random-effects models to assess diagnostic ***16 742 participants (2097 major depression cases) from 54 studies were included. The correlation between PHQ-8 and PHQ-9 scores was 0.996 (95% confidence interval 0.996 to 0.996). The standard cutoff score of 10 for the PHQ-9 maximized sensitivity + specificity for the PHQ-8 among studies that used a semi-structured diagnostic interview reference standard (N = 27). At cutoff 10, the PHQ-8 was less sensitive by 0.02 (−0.06 to 0.00) and more specific by 0.01 (0.00 to 0.01) among those studies (N = 27), with similar results for studies that used other types of interviews (N = 27). For all 54 primary studies combined, across all cutoffs, the PHQ-8 was less sensitive than the PHQ-9 by 0.00 to 0.05 (0.03 at cutoff 10), and specificity was within 0.01 for all cutoffs (0.00 to 0.01).ConclusionsPHQ-8 and PHQ-9 total scores were similar. Sensitivity may be minimally reduced with the PHQ-8, but specificity is similar.

关键词： Depression diagnostic accuracy individual participant data meta-analysis meta-analysis PHQ-8 PHQ-9 screening systematic review

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