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Active food packages for cake conservation: Antifungal potential of bean starch biodegradable films with orange peel essential oil

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International Journal of Biological Macromolecules 2025年 310卷

作者： Lemos, Graciele Saraiva Vitoria, Jéssica Silveira Fonseca, Laura Martins Pires, Juliani Buchveitz Silva, Francine Tavares da Siebeneichler, Tatiane Jéssica Pacheco, Camila de Oliveira Gandra, Eliezer Avila Zavareze, Elessandra da Rosa Graduate Program in Food Science and Technology Department of Agro-industrial Science and Technology Federal University of Pelotas RS Pelotas96010-900 Brazil Graduate Program in Nutrition and Food Center for Chemical Pharmaceutical and Food Sciences Federal University of Pelotas RS Pelotas96010-900 Brazil

This study aimed to apply antifungal films as biodegradable active packages for cake conservation. Native or octenyl succinic anhydride (OSA)-modified carioca bean starches (4 %, w/v) were used to produce films incorporated with orange peel essential oil (5 % and 10 %, v/w). D-limonene was determined as the major compound (94.25 %) in orange peel essential oil. Filmogenic solutions exhibited greater stability due to OSA modification. The films presented a continuous morphology, high luminosity (97.0 %), and low opacity (8.6 %), moisture content of 24.2 %, solubility in water of 38.0 %, and a water vapor permeability of 4.97 ***/***. They remained intact after 24 h of immersion in water. The mechanical properties included a tensile strength (5.44 MPa) and an elongation at break (52.0 %). The antifungal activity of the essential oil and the films against Penicillium crustosum and Aspergillus flavus was high, with higher inhibition of A. flavus. Films produced from OSA-modified starch exhibited improved morphological properties, showing increased homogeneity over native starch films. The bean starch films with 10 % orange peel essential oil exhibited an enhanced antifungal effect. They were used for the application in cake conservation, displaying high inhibition of fungi with the potential for the formation of biodegradable active food packaging. © 2025 Elsevier B.V.

关键词： Citrus sinensis L OSA-modified starch Phaseolus vulgaris

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The revolution of type I organic photosensitizers: current strategies and future directions

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science Bulletin 2025年第8期70卷 1203-1206页

作者： Yang, Mengyao Zhou, Luyan Zhao, Yuan-Yuan Swamy, Kunemadihalli Mathada Kotraiah Chen, Aibing Yoon, Juyoung College of Chemical and Pharmaceutical Engineering Hebei University of Science and Technology Shijiazhuang050018 China Department of Chemistry and Nanoscience Ewha Womans University Seoul03760 Korea People's Democratic Rep Graduate Program in Innovative Biomaterials Convergence Ewha Womans University Seoul03760 Korea People's Democratic Rep

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Potential Use of Yam Starch: Thermal Protection of Tea Tree Essential Oil Encapsulated by Electrospinning

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Starch/Staerke 2025年第5期77卷

作者： Souza, Estefania Júlia Dierings de Santos, Felipe Nardo dos Pires, Juliani Buchveitz Cruz, Elder Pacheco da Fonseca, Laura Martins Gandra, Eliezer Avila Dias, Alvaro Renato Guerra Zavareze, Elessandra da Rosa Graduate Program in Food Science and Technology Department of Agroindustrial Science and Technology Federal University of Pelotas RS Pelotas Brazil Center of Chemical Pharmaceutical and Food Sciences Federal University of Pelotas RS Pelotas Brazil

Encapsulation of essential oils may broaden their application in the food chain by promoting their protection. Thus, starch ultrafine fibers are effective green vehicles to increase the thermal stability of bioactive compounds. The objective of this study was to evaluate the antimicrobial activity of tea tree essential oil (TTEO) and perform its encapsulation in yam starch ultrafine fibers by electrospinning. The TTEO was evaluated by chemical composition, thermal properties, and antimicrobial action against Escherichia coli and Staphylococcus aureus bacteria. The ultrafine fibers containing TTEO were evaluated by morphology, size distribution, water contact angle, Fourier transform infrared (FTIR) spectra, thermal properties, and loading capacity (LC). The main compounds of TTEO were 4-terpineol (49.13%) and α-terpineol (11.46%). The free TTEO presented inhibition zones ranging from approximately 5 to 20 mm for E. coli and S. aureus bacteria. The polymeric solutions presented a maximum electrical conductivity of 3.44 mS·cm−1 and pseudoplastic behavior by rheological measurements. The ultrafine fibers containing TTEO displayed continuous morphology, mean diameters ranging from 187 to 231 nm, and LC ranging from 12.1% to 13.4%. The increase in TTEO concentration in the ultrafine fibers promoted an increase in the contact angle with water, reducing its hydrophilicity. Yam starch ultrafine fibers are a promising structure for the encapsulation of TTEO, increasing its thermal stability for future applications in the food chain. © 2025 Wiley-VCH GmbH.

关键词： Escherichia coli

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Dual Delivery of Light/Prodrug Nanoparticles Using Tumor-Implantable Micro Light-Emitting Diode on an Optofluidic System for Combinational Glioma Treatment

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ACS Nano 2025年第18期19卷 17393-17409页

作者： Goo, Jagyeong Lee, Jun Seo Park, Junwon Jeon, Seong Ik Kim, Jeongrae Yun, Wan Su Shim, Nayeon Moon, Yujeong Song, Sunejeong Kim, Jinseong Cho, Hanhee Jeong, Ju Yeon Lee, Ju Seung Han, Sangheon Lee, Hyeon-Ju Koh, Won-Gun Chang, Won Seok Kim, Tae-Il Kim, Kwangmeyung Department of Chemical and Biomolecular Engineering Yonsei University 50 Yonsei-ro Seodaemun-gu Seoul03722 Korea Republic of 2066 Seobu-ro Jangan-gu Suwon16419 Korea Republic of Department of Neurosurgery and Brain Research Institute College of Medicine Yonsei University 50-1 Yonsei-Ro Seodaemun-gu Seoul03722 Korea Republic of College of Pharmacy Graduate School of Pharmaceutical Sciences Ewha Womans University 52 Ewhayeodae-gil Seodaemun-gu Seoul03760 Korea Republic of KU-KIST Graduate School of Converging Science and Technology Korea University 145 Anam-ro Seongbuk-gu Seoul02841 Korea Republic of Gradutate Program in Innovative Biomaterials Convergence Ewha Womans University 52 Ewhayeodae-gil Seodaemun-gu Seoul03760 Korea Republic of

Glioma is a highly lethal tumor with a poor prognosis, in which the presence of the blood-brain barrier (BBB) and skull significantly limits treatment options. To address this, a tumor-implantable optofluidic system (LED-SC), consisting of a microsized LED (microLED) and a microsyringe chip (SC), is proposed to deliver both light and prodrug nanoparticles (PNPs) directly to brain glioma. The LED-SC combines microLED and SC to enable intratumoral administration of light and PNPs for chemophotodynamic therapy. PNPs, self-assembled nanoparticles of verteporfin (VPF)-doxorubicin (DOX) prodrug, are cleaved by the enzyme cathepsin B, releasing active drugs specifically within tumor cells. In vitro studies show that PNPs are taken up by glioma cells and exhibit enhanced cytotoxicity under light irradiation. The PNPs-loaded LED-SC can be implanted into glioma, wherein PNPs are slowly diffused through the tumor, bypassing the BBB, and it also ensures effective light delivery in glioma beneath the skull, boosting chemo-photodynamic therapy. In glioma mouse models, PNP-loaded LED-SC implantation showed a 3.9-fold improvement in PNP delivery efficiency over intravenous administration, leading to better drug distribution and therapeutic results. The PNPs-loaded LED-SC offers a promising and minimally invasive solution for glioma treatment, overcoming the barriers of the BBB and skull while reducing systemic toxicity. © 2025 American Chemical Society.

关键词： Controlled drug delivery

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Cytocompatible and antibacterial Fe-, Cu- and Zn-substituted calcium hydroxyapatite materials for skin applications

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Ceramics International 2025年第9期51卷 11286-11296页

作者： Lukaviciute, L. Lukowiak, A. Stankeviciute, Z. Junka, A. Mortimer, M. Zarkov, A. Yang, J.-C. Ganceviciene, R. Kareiva, A. Faculty of Chemistry and Geosciences Vilnius University Naugarduko st. 24 Vilnius03225 Lithuania Institute of Low Temperature and Structure Research Polish Academy of Sciences Okolna 2 Wroclaw50422 Poland Department of Pharmaceutical Microbiology and Parasitology Wroclaw Medical University Borowska 211A Wroclaw50556 Poland Laboratory of Environmental Toxicology National Institute of Chemical Physics and Biophysics Akadeemia tee 23 Tallinn12618 Estonia Graduate Institute of Nanomedicine and Medical Engineering International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering Research Center of Biomedical Device Research Center of Digital Oral Science and Technology Taipei Medical University Taiwan Faculty of Medicine Vilnius University M.K. Ciurlionio st. 21 Vilnius03101 Lithuania

Calcium hydroxyapatite (C10(PO4)6(OH)2;CHAp) and metal-substituted samples (Fe:CHAp, Cu:CHAp, and Zn:CHAp) were synthesized using a recently developed method. This method involved the wet precipitation of amorphous calcium phosphate (ACP), followed by solid-state reaction synthesis of α-tricalcium phosphate (α-TCP), and finally hydrothermal synthesis of CHAp. The effect of Fe3+, Cu2+, and Zn2+ substitution on the phase purity and antimicrobial properties of CHAp are summarized in this study. Notably, it highlights the phase purity of CHAp and Zn:CHAp (in the presence of Fe3+ and Cu2+ ions, the α- and β-TCP phases have formed) as well as the antimicrobial activity of Zn:CHAp and Cu:CHAp against Staphylococcus aureus and Candida albicans. The synthesized nanosized CHAp, Fe:CHAp, Cu:CHAp, and Zn:CHAp samples were used as additives in the preparation of skin creams. In vitro biological studies of the resulting skin creams demonstrated their antimicrobial activity against Pseudomonas aeruginosa, and showed a reduction in osteoblasts cells viability of in the range of 20–40 %. The addition of zinc enhances antimicrobial efficacy but reduces biocompatibility, while copper maintains both high antimicrobial activity and biocompatibility, making it more suitable for the development of medical or cosmetic materials. Dermal creams containing CHAp with copper and iron ions also show significant antimicrobial activity while preserving good cell viability. These results highlight the importance of optimizing the balance between antimicrobial effectiveness and biocompatibility in these materials. © 2024

关键词： Biocompatibility

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Improvement of mitochondrial function in Duchenne muscular dystrophy skeletal muscle cells by coenzyme Q₁₀ delivery to mitochondria

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Biochemical and Biophysical Research Communications 2025年 771卷 152003页

作者： Sato, Itsumi Sasaki, Daisuke Abe, Jiro Yamanouchi, Keitaro Takeda, Atsuhito Yamada, Yuma Faculty of Pharmaceutical Sciences Hokkaido University Sapporo Japan Faculty of Medicine and Graduate School of Medicine Hokkaido University Sapporo Japan Department of Veterinary Physiology of Agricultural and Life Sciences The University of Tokyo Tokyo Japan Fusion Oriented Research for Disruptive Science and Technology (FOREST) Program Japan Science and Technology Agency (JST) Japan Saitama Japan

Duchenne muscular dystrophy (DMD) is a genetic disease, with no curative therapy, and is associated with mitochondrial dysfunction in skeletal muscle. Thus, mitochondrial treatment is a potential therapy for DMD. However, few studies have reported on such treatments because of the difficulty of drug delivery to mitochondria. Here, we used MITO-Porter to deliver coenzyme Q₁₀ to the mitochondria of primary skeletal muscle cells isolated from DMD model rats. Our results show the therapeutic potential of mitochondrial activation for DMD. © 2025 Elsevier Inc.

关键词： Coenzyme Q10 Decreased mitochondrial respiratory capacity Drug delivery system Duchenne muscular dystrophy Nanoparticle Skeletal muscle cell

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Pitaya (Hylocereus polyrhizus) peel powder: a source of pigments, phenolic and antioxidants activity for use in food hydrocolloids

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Food Bioscience 2025年 68卷

作者： de Oliveira, Gabriela de Lima Costa, Igor Henrique dos Santos Lima, Marcos Macedo Dantas, Aline Guerra Dias, Alvaro Renato da Silva Campelo Borges, Graciele Laboratory of Biopolymers and Nanotechnology in Food (BioNano) Graduate Program in Food Science and Technology Department of Agroindustrial Science and Technology Federal University of Pelotas RS Pelotas 96010-900 Brazil Federal Institute of Education Science and Technology Sertão Pernambucano Department of Food Technology Campus Petrolina Rod. BR 407 Km 08 S/N Jardim São Paulo Pernambuco Petrolina CEP 56314-520 Brazil Program Pos Graduate Food Science and Techolgy Federal University of Paraíba PB João Pessoa Brazil Center of Sciences Chemistry Pharmaceutical and Foods Federal University of Pelotas RS Pelotas 96010-900 Brazil

Pitaya is an exotic fruit that is widely consumed fresh or processed. The consumption of pitaya generates approximately 30 % of co-products, mainly peels, that contain substances of interest to the food industry, such as fibers, phenolics, and betacyanins. This pigment is responsible for the coloration of the peel of fruits and can be exploited for technological properties such as natural colorant for application in food. This study aimed to evaluate the physical-chemical characteristics, profile of phenolic, antioxidant activity, and digestibility of pitaya peel powder (PPP) for application in food gel models. Pitaya peels were in an oven with forced air circulation at 60, 70, and 80 °C. In general, PPP dried at different temperatures presented similar characteristics: moisture 4.20, a_w (0.210–0.243), and varied pH (4.5–5). However, PPP dried at 60 °C presented major content soluble solids (32.03 °Brix), betacyanins, phenolic compounds, and consequently, a minor darkening index. On the other hand, PPP dried at 70 and 80 °C showed a reduction in betacyanins content, consequently in color parameters;however, maintenance phenolics contributed high antioxidant activity by DPPH• and ORAC radicals. Furthermore, the PPP dried at 60 °C showed stability in different pH varying from 3 to 7, and the potential of coloring to different food hydrocolloids such as cassava starch and gelatin showed potential power during 7 days of storage. Thus, PPP demonstrated technological potential for the application of such colorants in food as alternatives to artificial compounds. © 2025 Elsevier Ltd

关键词： Betalains Bioactive compounds Food gels Gastrointestinal digestion Principal component analysis

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Comparative analysis of multiple DNA double-strand break repair pathways in CRISPR-mediated endogenous tagging

Communications Biology

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Communications Biology 2025年第1期8卷 1-12页

作者： Tei, Chiharu Hata, Shoji Mabuchi, Akira Okuda, Shotaro Ito, Kei K. Genova, Mariya Fukuyama, Masamitsu Yamamoto, Shohei Chinen, Takumi Toyoda, Atsushi Kitagawa, Daiju Department of Physiological Chemistry Graduate School of Pharmaceutical Sciences The University of Tokyo Bunkyo Tokyo Japan Precursory Research for Embryonic Science and Technology (PRESTO) Program Japan Science and Technology Agency Honcho Kawaguchi Saitama Japan Zentrum für Molekulare Biologie Universität Heidelberg DKFZ-ZMBH Allianz Heidelberg Germany Comparative Genomics Laboratory and Advanced Genomics Center National Institute of Genetics Mishima Shizuoka Japan

CRISPR-mediated endogenous tagging is a powerful tool in biological research. Inhibiting the non-homologous end joining (NHEJ) pathway has been shown to improve the low efficiency of accurate knock-in via homology-directed repair (HDR). However, the influence of alternative double-stranded break (DSB) repair pathways on knock-in remains to be fully explored. In this study, our long-read amplicon sequencing analysis reveals various patterns of imprecise repair in CRISPR-mediated knock-in, even with NHEJ inhibition. Further suppressing either microhomology-mediated end joining (MMEJ) or single-strand annealing (SSA) reduces nucleotide deletions around the cut site, thereby elevating knock-in accuracy. Additionally, imprecise donor integration is reduced by inhibiting SSA, but not MMEJ. Particularly, SSA suppression reduced asymmetric HDR, a specific imprecise integration pattern, which we further confirm using a novel reporter system. These findings demonstrate the complex interplay of multiple DSB repair pathways in CRISPR-mediated knock-in and offer novel strategies, including SSA pathway targeting, to improve precise gene editing efficiency. © The Author(s) 2025.

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SMEPPI: An indenone derivative that selectively inhibits M1 macrophage activation and enhances phagocytic activity

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Biomedicine and Pharmacotherapy 2025年 183卷 117856-117856页

作者： Oh, Ji Hyun Jeong, Mi Gyeong Lee, Soheun Lim, Jihae Kang, Jio Bae, Myung Ae Ahn, Jin-Hee Hong, Jeong-Ho Hwang, Eun Sook College of Pharmacy and Graduate School of Pharmaceutical Sciences Ewha Womans University Seoul 03760 South Korea Gradutate Program in Innovative Biomaterials Convergence Ewha Womans University Seoul 03760 South Korea Drug Discovery Platform Research Center Korea Research Institute of Chemical Technology (KRICT) Daejeon 34114 South Korea Department of Chemistry Gwangju Institute of Science and Technology Gwangju 61005 South Korea Division of Life Sciences Korea University Seoul 02841 South Korea

SMEPPI is a small molecule synthesized as a derivative of KR-62980 that has anti-diabetic and anti-inflammatory activities. Despite the established physiological effects of KR-62980, the effects and benefits of SMEPPI remain largely unexplored. This study investigated the immunomodulatory functions of SMEPPI on macrophages and inflammatory diseases. SMEPPI did not affect the differentiation and maturation of bone marrow-derived monocytes into macrophages, nor did it affect the proliferation of M1 or M2 macrophages. Although SMEPPI did not affect M2 macrophage polarization, it significantly inhibited IL-1β and IL-6 cytokine production in both M1 macrophages and activated RAW264.7 macrophages. Importantly, SMEPPI inhibited the expression and phosphorylation of NF-κB p65 through inhibition of Akt expression, preventing its translocation to the nucleus. It also promoted p65 degradation through the stimulation of the proteasomal degradation pathway by inducing the expression of proteasome-related genes, thereby inhibiting p65 transcriptional activity. SMEPPI also enhanced the expression of various molecules associated with macrophage phagocytosis, including CD68, CD33, and lectins, thereby increasing phagocytic activity. Moreover, SMEPPI mitigated lipopolysaccharides-induced acute lung injury by suppressing IL-1β and IL-6 production in M1 macrophages and reduced mortality related to severe lung injury. These findings indicate that SMEPPI effectively regulates inflammatory diseases by impeding p65-induced cytokine production and enhancement of phagocytosis by M1 macrophages. © 2025

关键词： Acute lung injury Macrophage Mortality P65 Phagocytosis SMEPPI

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Violacein quantification using a smartphone coupled to an endoscopic camera: Quorum sensing inhibition in Chromobacterium violaceum

Microbe (Netherlands)

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Microbe (Netherlands) 2025年 6卷

作者： Casagrande, Camilla Voos, Monica Nunes, Franciane Batista dos Santos Alves, Camilla Filippi Verdi, Camila Marina Barin, Juliano Santos, Roberto Christ Vianna Department of Microbiology and Parasitology Federal University of Santa Maria (UFSM) Santa Maria Brazil Department of Food Science and Technology Federal University of Santa Maria Rio Grande do Sul Santa Maria Brazil Laboratory of Oral Microbiology Research (LAPEMICRO) Federal University of Santa Maria Rio Grande do Sul Brazil Graduate Program in Pharmaceutical Sciences Federal University of Santa Maria Rio Grande do Sul Brazil

Quorum sensing (QS) strongly regulates the biofilm formation mechanism in several microorganisms. The blockade of violacein production in Chromobacterium violaceum has been employed to indicate QS inhibition. Nevertheless, quantifying violacein is challenging due to the reliance on high-cost equipment and supplies. Consequently, this study compared the production and inhibition of violacein using a traditional spectrophotometric method and an alternative approach utilizing a Photometrix UVC Android application integrated with a USB endoscopic camera. The study standardized the growth of C. violaceum in several culture media and incubation times, then evaluated the pigment inhibition against salicylic acid. Results indicated that C. violaceum produced more violacein when cultivated in BHI broth for 24 h. Salicylic acid inhibited violacein production, even at sub-inhibitory concentrations, with a minimum inhibitory pigment concentration (125 µg/mL) and a minimum bactericidal concentration (2000 µg/mL). A comparison between application-based readings and the traditional method showed no significant differences, highlighting the potential of this technology as an essential tool in for QS inhibition and biofilm research. © 2025

关键词： Biofilm Colorimetric methods Smartphone Violacein

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