检索结果-内蒙古大学图书馆

HOS15 represses flowering by promoting GIGANTEA degradation in response to low temperature in Arabidopsis

Plant Communications 2023年第4期4卷 225-239页

作者： Gyeongik Ahn Hee Jin Park Song Yi Jeong Gyeong-Im Shin Myung Geun Ji Joon-Yung Cha Jeongsik Kim Min Gab Kim Dae-Jin Yun Woe-Yeon Kim Research Institute of Life Science Institute of Agricultural and Life ScienceGyeongsang National UniversityJinju 52828Republic of Korea Division of Applied Life Science(BK21 Four) Plant Biological Rhythm Research CenterPlant Molecular Biology and Biotechnology Research CenterGraduate School of Gyeongsang National UniversityJinju 52828Republic of Korea Department of Biological Sciences College of Natural SciencesChonnam National UniversityGwangju 61186Republic of Korea Faculty of Science Education and Interdisciplinary Graduate Program in Advanced Convergence Technology and Science Jeju National UniversityJeju 63243Republic of Korea College of Pharmacy and Research Institute of Pharmaceutical Science PMBBRCGyeongsang National UniversityJinju 52828Republic of Korea Institute of Glocal Disease Control Konkuk UniversitySeoul 05029Republic of Korea Key Laboratory of Molecular Epigenetics of the Ministry of Education(MOE) Northeast Normal UniversityChangchun 130024China

Flowering is the primary stage of the plant developmental transition and is tightly regulated by environmental factors such as light and ***,the mechanisms by which temperature signals are integrated into the photoperiodic flowering pathway are still poorly ***,we demonstrate that HOS15,which is known as a GI transcriptional repressor in the photoperiodic flowering pathway,controls flowering time in response to low ambient *** 16℃,the hos15 mutant exhibits an early flowering phenotype,and HOS15 acts upstream of photoperiodic flowering genes(GI,CO,and FT).GI protein abundance is increased in the hos15 mutant and is insensitive to the proteasome inhibitor ***,the hos15 mutant has a defect in low ambient temperature-mediated GI degradation,and HOS15 interacts with COP1,an E3 ubiquitin ligase for GI *** analyses of the hos15 cop1 double mutant revealed that repression of flowering by HOS15 is dependent on COP1 at 16℃.However,the HOS15-COP1 interaction was attenuated at 16℃,and GI protein abundance was additively increased in the hos15 cop1 double mutant,indicating that HOS15 acts independently of COP1 in GI turnover at low ambient *** study proposes that HOS15 controls GI abundance through multiple modes as an E3 ubiquitin ligase and transcriptional repressor to coordinate appropriate flowering time in response to ambient environmental conditions such as temperature and day length.

关键词： Arabidopsis flowering response low ambient temperature HOS15 GIGANTEA

来源：评论

学校读者我要写书评

暂无评论

Red onion skin extract rich in flavonoids encapsulated in ultrafine fibers of sweet potato starch by electrospinning

引用

Food Chemistry 2023年 406卷 134954页

作者： Cruz, Elder Pacheco da Jansen, Estefani Tavares Fonseca, Laura Martins Hackbart, Helen Cristina dos Santos Siebeneichler, Tatiane Jéssica Pires, Juliani Buchveitz Gandra, Eliezer Avila Rombaldi, Cesar Valmor Zavareze, Elessandra da Rosa Dias, Alvaro Renato Guerra Graduate Program in Food Science and Technology Department of Agroindustrial Science and Technology Federal University of Pelotas RS Pelotas96010-900 Brazil Center for Chemical Pharmaceutical and Food Sciences Federal University of Pelotas RS Pelotas96010-900 Brazil

Electrospinning encapsulation is a highly viable method to protect bioactive compounds and prevent their degradation. Hence, this study produced ultrafine fibers based on yellow and white sweet potato starches and a red onion skin extract (ROSE;0, 3, 6, and 9 %, w/w) using electrospinning. The fibers were evaluated for morphology, thermogravimetric properties, antioxidant, in vitro release simulation, thermal resistance (100 and 180 °C), and wettability. The fibers with ROSE presented 251–611 nm diameters, 67–78 % loading capacity, and 51.6–95.4 and 13.4–99.4 % thermal resistance (100 and 180 °C, respectively);apigenin presented the highest thermal protection. The phenolic compounds showed low release using 10 % ethanol and greater release with 50 % ethanol. The fibers with 9 % ROSE showed 2,2′-azino-bis(3-ethylbenzothiazoline) 6-sulfonic acid radical inhibition above 92 %. The ultrafine fibers and the unencapsulated ROSE showed inhibitory action against Escherichia coli and Staphylococcus aureus;only unencapsulated ROSE showed bactericidal activity. © 2022 Elsevier Ltd

关键词： Contact angle

来源：评论

学校读者我要写书评

暂无评论

Glucose-mediated mitochondrial reprogramming by cholesterol export at TM4SF5-enriched mitochondria-lysosome contact sites

引用

Cancer Communications 2024年第1期44卷 47-75页

作者： Ji Eon Kim So-Young Park Chulhwan Kwak Yoonji Lee Dae-Geun Song Jae Woo Jung Haesong Lee Eun-Ae Shin Yangie Pinanga Kyung-hee Pyo Eun Hae Lee Wonsik Kim Soyeon Kim Chang-Duck Jun Jeanho Yun Sun Choi Hyun-Woo Rhee Kwang-Hyeon Liu Jung Weon Lee Department of Pharmacy College of PharmacySeoul National UniversitySeoulRepublic of Korea Research Institute of Pharmaceutical Sciences College of PharmacySeoul National UniversitySeoulRepublic of Korea BK21 FOUR Community-Based Intelligent Novel Drug Discovery Education Unit College of Pharmacy and Research Institute of Pharmaceutical SciencesKyungpook National UniversityDaeguRepublic of Korea Department of Chemistry Seoul National UniversitySeoulRepublic of Korea College of Pharmacy Chung-Ang UniversitySeoulRepublic of Korea Natural Product Informatics Research Center Korea Institute of Science and Technology(KIST)Gangneung-siGangwon-doRepublic of Korea School of Life Sciences Gwangju Institute of Science and Technology(GIST)GwangjuRepublic of Korea Department of Biochemistry College of MedicineDong-A UniversityBusanRepublic of Korea Global AI Drug Discovery Center College of Pharmacy and Graduate School of Pharmaceutical SciencesEwha Womans UniversitySeoulRepublic of Korea Interdisciplinary Program in Genetic Engineering Seoul National UniversitySeoulRepublic of Korea

Background:Transmembrane 4 L six family member 5(TM4SF5)translocates subcellularly and functions metabolically,although it is unclear how intracellu-lar TM4SF5 translocation is linked to metabolic *** is thus of interests to understand how the traffic dynamics of TM4SF5 to subcellular endosomal membranes are correlated to regulatory roles of ***:Here,we explored the metabolic significance of TM4SF5 localization at mitochondria-lysosome contact sites(MLCSs),using in vitro cells and in vivo animal systems,via approaches by immunofluorescence,proximity labelling based proteomics analysis,organelle reconstitution ***:Upon extracellular glucose repletion following depletion,TM4SF5 became enriched at MLCSs via an interaction between mitochondrial FK506-binding protein 8(FKBP8)and lysosomal *** labeling showed molecular clustering of phospho-dynamic-related protein I(DRP1)and certain mitophagy receptors at TM4SF5-enriched MLCSs,leading to mitochondrial fis-sion and ***4SF5 bound NPC intracellular cholesterol transporter 1(NPC1)and free cholesterol,and mediated export of lysosomal cholesterol to mitochondria,leading to impaired oxidative phosphorylation but intact tri-carboxylic acid(TCA)cycle andβ-*** mouse models,hepatocyte Tm4sf5 promoted mitophagy and cholesterol transport to mitochondria,both with positive relations to liver ***:Our findings suggested that TM4SF5-enriched MLCSs regu-late glucose catabolism by facilitating cholesterol export for mitochondrial reprogramming,presumably while hepatocellular carcinogenesis,recapitulating aspects for hepatocellular carcinoma metabolism with mitochondrial repro-gramming to support biomolecule synthesis in addition to glycolytic energetics.

关键词： cholesterol fluorescent imaging glucose catabolism hepatocellular carcinogenesis mem-brane contact sites mitochondria function mitophagy oxidative phosphorylation protein-protein interaction tetraspanin

来源：评论

学校读者我要写书评

暂无评论

Actinidia deliciosa as a complemental therapy against nephropathy and oxidative stress in diabetic rats

引用

Food science and Human Wellness 2023年第6期12卷 1981-1990页

作者： Ali Y.Naoom Wenyi Kang Nora F.Ghanem Mohamed M.Abdel-Daim Fatma M.El-Demerdash Department of Medical Laboratory Techniques Imam Ja'afar Al-Sadiq UniversityAl-Muthanna 66002Iraq National R&D Center for Edible Fungus Processing Technology Henan UniversityKaifeng 475004China Department of Zoology Faculty of ScienceKafr ElSheikh UniversityKafr El Sheikh 33516Egypt Department of Pharmaceutical Sciences Pharmacy ProgramBatterjee Medical CollegeJeddah 21442Saudi Arabia Pharmacology Department Faculty of Veterinary MedicineSuez Canal UniversityIsmailia 41522Egypt Department of Environmental Studies Institute of Graduate Studies and ResearchAlexandria UniversityAlexandria 21526Egypt

This study aimed to evaluate the anti-hyperglycemic and antioxidant role of Actinidia deliciosa(kiwifruits)aqueous extract in streptozotocin-treated *** were distributed into;control,*** aqueous extract(ADAE;1 g/kg orally),streptozotocin(STZ;50 mg/kg,i.p,single dose),and STZ plus ADAE,*** showed that ADAE had high antioxidant and radical scavenging *** in blood sugar level,lipid peroxidation(LPO),kidney function biomarkers,and perturbations in hematological parameters were observed in diabetic ***,enzymatic and non-enzymatic antioxidants,protein content,and alkaline phosphatase(ALP)activity ***,histological,immunohistochemical alpha-smooth muscle actin immunoreactivity(α-SMA-ir)and histochemical(collagen,total protein,DNA,and RNA)alterations were observed in rat ***,STZ produced upregulation of inflammatory associated genes(tumor necrosis factor-alpha;TNF-αand transforming growth factorβ1;TGF-β1)and triggered apoptosis by upregulating apoptotic related gene[Bcl2-associated X protein(Bax)]and downregulating anti-apoptotic related gene B-cell lymphoma-2(Bcl-2)based on real-time PCR ***,diabetic rats administered with ADAE showed significant restoration in LPO,antioxidant status,and biochemical indices besides tissue architecture,and genes improvement regarding STZ ***,*** has a valuable ameliorative infl uence and can restore glucose levels and improve kidney dysfunction in diabetic rats.

关键词： Diabetes mellitus Actinidia deliciosa Inflammation Apoptosis Oxidative stress Nephropathy

来源：评论

学校读者我要写书评

暂无评论

Revisiting some overlooked registered Thai traditional medicine preparations: an alert to a regulatory affair

引用

Bulletin of the National Research Centre 2022年第1期46卷 1-9页

作者： Vimolmangkang, Sornkanok Rani, Dolly Prestwong, Naruemon Sutcharitchan, Chayanis Pakdeesattayapong, Duangkamol Department of Pharmacognosy and Pharmaceutical Botany Faculty of Pharmaceutical Sciences Chulalongkorn University Bangkok Thailand Center of Excellence in Plant Produced Pharmaceuticals Faculty of Pharmaceutical Sciences Chulalongkorn University Bangkok Thailand Graduate Program in Pharmaceutical Science and Technology Faculty of Pharmaceutical Sciences Chulalongkorn University Bangkok Thailand Herbal Products Division Food and Drug Administration Thailand Ministry of Public Health Nonthaburi Thailand

This study evaluated the heavy metal identity and content of registered Thai Traditional medicine (TTM) preparations in Thailand to ensure consumer safety. Both qualitative and quantitative information about the elemental composition of the heavy metal content in each TTM crude drug and the heavy metal content in some registered TTM preparations in Thailand was performed. Seven kinds of mineral-based TTM crude drugs, namely realgar, orpiment, Chinese powder, Sen, vermilion, natural vermilion, and cinnabar, were analyzed with X-ray diffraction and scanning electron microscopy and energy-dispersive spectroscopy techniques to determine the type of metal and elemental composition to confirm their chemical formulas. Furthermore, the number of heavy metals, such as arsenic (As), lead (Pb), and mercury (Hg), was in three samples of realgar-containing preparations; one sample of Sen-containing preparation, and eight samples of cinnabar-containing preparations. Heavy metals were determined with inductively coupled plasma-optical emission spectrometry. It was observed that realgar and orpiment consisted of arsenic sulfide (AsS) and arsenic trisulfide (As2S3), respectively. Both crude drugs contained approximately 50% of As. Vermilion, natural vermilion, and cinnabar consisted of mercuric sulfide (HgS), with Hg accounting for approximately 66%. Sen consisted of Pb (II, IV) oxide (Pb3O4) with an approximate Pb percentage of 80%. However, Pb was absent in Chinese powder and consisted mainly of calcium carbonate (CaCO3). A traditional detoxification procedure can reduce the amount of As and Hg in processed crude drugs by at least 20%. Pb was higher in some TTM preparations, and no CaCO3 was detected in Chinese powder. Our results raise concerns on both safety and efficacy to consumers and alert public health policymakers that they should implement regulations so that the quality (authenticity) and quantity of elemental medicine used in traditional medicine are correctly labeled a

关键词：

来源：评论

学校读者我要写书评

暂无评论

Improvement of mitochondrial function in Duchenne muscular dystrophy skeletal muscle cells by coenzyme Q₁₀ delivery to mitochondria

引用

Biochemical and Biophysical Research Communications 2025年 771卷 152003页

作者： Sato, Itsumi Sasaki, Daisuke Abe, Jiro Yamanouchi, Keitaro Takeda, Atsuhito Yamada, Yuma Faculty of Pharmaceutical Sciences Hokkaido University Sapporo Japan Faculty of Medicine and Graduate School of Medicine Hokkaido University Sapporo Japan Department of Veterinary Physiology of Agricultural and Life Sciences The University of Tokyo Tokyo Japan Fusion Oriented Research for Disruptive Science and Technology (FOREST) Program Japan Science and Technology Agency (JST) Japan Saitama Japan

Duchenne muscular dystrophy (DMD) is a genetic disease, with no curative therapy, and is associated with mitochondrial dysfunction in skeletal muscle. Thus, mitochondrial treatment is a potential therapy for DMD. However, few studies have reported on such treatments because of the difficulty of drug delivery to mitochondria. Here, we used MITO-Porter to deliver coenzyme Q₁₀ to the mitochondria of primary skeletal muscle cells isolated from DMD model rats. Our results show the therapeutic potential of mitochondrial activation for DMD. © 2025 Elsevier Inc.

关键词： Coenzyme Q10 Decreased mitochondrial respiratory capacity Drug delivery system Duchenne muscular dystrophy Nanoparticle Skeletal muscle cell

来源：评论

学校读者我要写书评

暂无评论

Chlorine-containing polyacetoxybriarane diterpenoids from the octocoral Junceella fragilis

引用

RSC Advances 2024年第24期14卷 17195-17201页

作者： Do, Hai Nhat Chen, Yu-Ta Chien, Su-Ying Chen, You-Ying Zhang, Mingzi M. Tsou, Lun Kelvin Chen, Jih-Jung Wen, Zhi-Hong Lo, Yi-Hao Zheng, Li-Guo Sung, Ping-Jyun Department of Marine Biotechnology and Resources National Sun Yat-sen University Kaohsiung804201 Taiwan National Museum of Marine Biology & Aquarium Pingtung944401 Taiwan Department of Family Medicine Zuoying Armed Forces General Hospital Kaohsiung813204 Taiwan Instrumentation Center National Taiwan University Taipei106319 Taiwan Institute of Molecular and Genomic Medicine National Health Research Institutes Miaoli350401 Taiwan Institute of Biotechnology and Pharmaceutical Research National Health Research Institutes Miaoli350401 Taiwan Department of Pharmacy School of Pharmaceutical Sciences National Yang Ming Chia Tung University Taipei112304 Taiwan Shu-Zen Junior College of Medicine and Management Kaohsiung821004 Taiwan Institute of Medical Science and Technology National Sun Yat-sen University Kaohsiung804201 Taiwan Doctoral Degree Program in Marine Biotechnology National Sun Yat-sen University Kaohsiung804201 Taiwan Chinese Medicine Research and Development Center China Medical University Hospital Taichung404394 Taiwan Graduate Institute of Natural Products Kaohsiung Medical University Kaohsiung807378 Taiwan PhD Program in Pharmaceutical Biotechnology Fu Jen Catholic University New Taipei City242062 Taiwan

The chemical screening of an octocoral identifed as Junceella fragilis has led to the isolation of five chlorinated briarane-type diterpenoids, including three known metabolites, gemmacolide X (1), frajunolide I (2), and fragilide F (3), along with two new analogs, 12α-acetoxyfragilide F (4) and 12α-acetoxyjunceellin (5). Single-crystal X-ray diffraction analysis was carried out to determine the absolute configurations of 1 and 2, while the structures of new compounds 4 and 5 were ascertained with 2D NMR experiments. Briaranes 1 and 3-5 were active in enhancing alkaline phosphatase (ALP) activity. © 2024 The Royal Society of Chemistry.

关键词： Metabolites

来源：评论

学校读者我要写书评

暂无评论

16-Hydroxybriaranes from the octocoral Briareum stechei

引用

Phytochemistry Letters 2023年第1期57卷 92-95页

作者： Liu, Chia-Jung Wang, Chien-Chiao Chang, Chun-Feng Zhang, Mingzi M. Tsou, Lun Kelvin Wen, Zhi-Hong Hwang, Tsong-Long Chen, You-Ying Sung, Ping-Jyun Department of Marine Biotechnology and Resources National Sun Yat-sen University Kaohsiung 804201 Taiwan National Museum of Marine Biology and Aquarium Pingtung 944401 Taiwan Graduate Institute of Natural Products College of Medicine Chang Gung University Taoyuan 333323 Taiwan Graduate Institute of Biomedical Sciences College of Medicine Chang Gung University Taoyuan 333323 Taiwan Division of Urology Department of Surgery Kaohsiung Armed Forces General Hospital Kaohsiung 802301 Taiwan Institute of Molecular and Genomic Medicine National Health Research Institutes Miaoli Zhunan 350401 Taiwan Institute of Biotechnology and Pharmaceutical Research National Health Research Institutes Miaoli Zhunan 350401 Taiwan Department of Anesthesiology Chang Gung Memorial Hospital Taoyuan 333008 Taiwan Research Center for Chinese Herbal Medicine Graduate Institute of Healthy Industry Technology College of Human Ecology Chang Gung University of Science and Technology Taoyuan 333324 Taiwan Department of Chemical Engineering Ming Chi University of Technology New Taipei 243303 Taiwan Chinese Medicine Research and Development Center China Medical University Hospital Taichung 404394 Taiwan Graduate Institute of Natural Products Kaohsiung Medical University Kaohsiung 807378 Taiwan Ph.D. Program in Pharmaceutical Biotechnology Fu Jen Catholic University New Taipei City 242062 Taiwan

Two new 16-hydroxybriaranes, 11-dehydroxybriavioid B (1) and 12-epi-briastecholide L (2), have been isolated from an algal-containing octocoral identified as Briareum stechei. The structures of metabolites 1 and 2 were corroborated by extensive 2D-NMR studies and comparison with literature data. Briarane 2 was found to reduce the release of inducible nitric oxide synthase (iNOS) to 87.92 %, at a concentration of 10 μM. © 2023 Phytochemical Society of Europe

关键词： Briarane Briareum stechei Briastecholide Briavioid iNOS

来源：评论

学校读者我要写书评

暂无评论

Discovery of small-molecule activators of nicotinamide phosphoribosyltransferase(NAMPT)and their preclinical neuroprotective activity

引用

细胞研究（英文版） 2022年第6期32卷 570-584页

作者： Hong Yao Minghui Liu Leibo Wang Yumeng Zu Chou Wu Chenyu Li Ruoxi Zhang Haigen Lu Feifei Li Shuang Xi Shuangquan Chen Xuanyu Gu Tianya Liu Jie Cai Shirong Wang Maojun Yang Guo-Gang Xing Wei Xiong Lan Hua Yefeng Tang Gelin Wang School of Pharmaceutical Sciences Beijing Advanced Innovation Center for Structural BiologyMinistry of Education Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical BiologyTsinghua UniversityBeijingChina Joint Graduate Program of Peking-Tsinghua-NIBS School of Life SciencesPeking UniversityBeijingChina School of Pharmaceutical Sciences Beijing Advanced Innovation Center for Structural BiologyMinistry of Education Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical BiologyTsinghua UniversityBeijingChina School of Pharmaceutical Sciences Beijing Advanced Innovation Center for Structural BiologyMinistry of Education Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical BiologyTsinghua UniversityBeijingChina Joint Graduate Program of Peking-Tsinghua-NIBS School of Life SciencesTsinghua UniversityBeijingChina Tsinghua-Peking Joint Center for Life Sciences Tsinghua UniversityBeijingChina Ministry of Education Key Laboratory of Protein Science Tsinghua-Peking Joint Center for Life SciencesBeijing Advanced Innovation Center for Structural BiologySchool of Life SciencesTsinghua UniversityBeijingChina Neuroscience Research Institute Peking UniversityBeijingChina Beijing Advanced Innovation Center for Intelligent Robots and System Beijing Institute of TechnologyBeijingChina School of Life Sciences Tsinghua UniversityBeijingChina GHDDI BeijingChina

The decline of nicotinamide adenine dinucleotide(NAD)occurs in a variety of human pathologies including ***-boosting agents can provide neuroprotective ***,we report the discovery and development of a class of potent activators(NATs)of nicotinamide phosphoribosyltransferase(NAMPT),the rate-limiting enzyme in the NAD salvage *** obtained the crystal structure of NAMPT in complex with the NAT,which defined the allosteric action of NAT near the enzyme active *** optimization of NAT further revealed the critical role of K189 residue in boosting NAMPT *** effectively increased intracellular levels of NAD and induced subsequent metabolic and transcriptional ***,NATs exhibited strong neuroprotective efficacy in a mouse model of chemotherapy-induced peripheral neuropathy(CIPN)without any overt *** findings demonstrate the potential of NATs in the treatment of neurodegenerative diseases or conditions associated with NAD level decline.

关键词： Neural stem cells X-ray crystallography

来源：评论

学校读者我要写书评

暂无评论

Isolation of 24-homoscalarane sesterterpenoids from a sponge of the genus Lendenfeldia

引用

Phytochemistry Letters 2024年 61卷 177-181页

作者： Zheng, Li-Guo Chen, You-Yan Liaw, Chia-Ching Lin, Yu-Chi Chien, Su-Ying Lo, Yi-Hao Tsai, Yu-Chi Hu, Hao-Chun Chen, You-Ying Hwang, Tsong-Long Ou, Tzu-Ming Sung, Ping-Jyun Doctoral Degree Program in Marine Biotechnology National Sun Yat-sen University Kaohsiung 804201 Taiwan National Museum of Marine Biology and Aquarium Pingtung 944401 Taiwan School of Traditional Chinese Medicine College of Medicine Chang Gung University Taoyuan 333323 Taiwan Division of Chinese Materia Medica Development National Research Institute of Chinese Medicine Ministry of Health and Welfare Taipei 112304 Taiwan Department of Biochemical Science and Technology National Chiayi University Chiayi 600355 Taiwan Instrumentation Center National Taiwan University Taipei 106319 Taiwan Department of Family Medicine Zuoying Armed Forces General Hospital Kaohsiung 813204 Taiwan Shu-Zen Junior College of Medicine and Management Kaohsiung 821004 Taiwan Institute of Medical Science and Technology National Sun Yat-sen University Kaohsiung 804201 Taiwan School of Chinese Medicine College of Chinese Medicine China Medical University Taichung 404333 Taiwan Graduate Institute of Natural Products College of Medicine Chang Gung University Taoyuan 333323 Taiwan Research Center for Chinese Herbal Medicine College of Human Ecology Chang Gung University of Science and Technology Taoyuan 333324 Taiwan Graduate Institute of Health Industry Technology College of Human Ecology Chang Gung University of Science and Technology Taoyuan 333324 Taiwan Department of Anesthesiology Chang Gung Memorial Hospital Taoyuan 333423 Taiwan Department of Chemical Engineering Ming Chi University of Technology New Taipei City 243303 Taiwan Division of Gastroenterology Department of Internal Medicine Kaohsiung Armed Forces General Hospital Kaohsiung 802301 Taiwan Department of Marine Biotechnology and Resources National Sun Yat-sen University Kaohsiung 804201 Taiwan Chinese Medicine Research and Development Center China Medical University Hospital Taichung 404394 Taiwan Graduate Institute of Natural Products Kaohsiung Medical University Kaohsiung 807378 Taiwan Program in Ph

The chemical screening of an algae-containing marine sponge identified as Lendenfeldia species has isolated two 24-homoscalarane sesterterpenoids, including a known compound, felixin A (1) and a new analogue, lendenfeldarane V (2). The structure of 1, obtained in a previous study, was cited for the first time in this study via single-crystal X-ray diffraction analysis. The structure of 2 was ascertained via 2D NMR experiments and a literature review. The absolute configurations of 1 and 2 were delineated with DP4+ computation and specific optical rotation. Homoscalarane 1 exhibited cytotoxicity towards MG63 human osteosarcoma cells. © 2024 Phytochemical Society of Europe

关键词： Felixin Homoscalarane Lendenfeldarane Lendenfeldia MG63

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：