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Calcification in free-living coralline algae is strongly influenced by morphology: Implications for susceptibility to ocean acidification (vol 11, 11232, 2021)

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SCIENTIFIC REPORTS 2021年第1期11卷 1-14页

作者： Schubert, Nadine Hofmann, Laurie C. Saa, Antonella C. Almeida Moreira, Anderson Camargo Arenhart, Rafael Guntzel Fernandes, Celso Peres de Beer, Dirk Horta, Paulo A. Silva, Joao CCMAR - Center of Marine Sciences University of Algarve Campus Gambelas 8005-139 Faro Portugal Phycology Laboratory Botany Department Center for Biological Sciences Federal University of Santa Catarina Campus Trindade Florianopolis 88010-970 Brazil Graduate Program in Oceanography (PPGOCEANO) Center for Physical and Mathematical Sciences Federal University of Santa Catarina Campus Trindade Florianopolis 88010-970 Brazil Microsensor Group Max Planck Institute for Marine Microbiology Celsiusstrasse 1 28359 Bremen Germany Porous Media and Thermophysical Properties Laboratory (LMPT) Mechanical Engineering Department Federal University of Santa Catarina Campus Trindade Florianopolis 88010-970 Brazil

Rhodolith beds built by free-living coralline algae are important ecosystems for marine biodiversity and carbonate production. Yet, our mechanistic understanding regarding rhodolith physiology and its drivers is still limited. Using three rhodolith species with different branching morphologies, we investigated the role of morphology in species’ physiology and the implications for their susceptibility to ocean acidification (OA). For this, we determined the effects of thallus topography on diffusive boundary layer (DBL) thickness, the associated microscale oxygen and pH dynamics and their relationship with species’ metabolic and light and dark calcification rates, as well as species’ responses to short-term OA exposure. Our results show that rhodolith branching creates low-flow microenvironments that exhibit increasing DBL thickness with increasing branch length. This, together with species’ metabolic rates, determined the light-dependent pH dynamics at the algal surface, which in turn dictated species’ calcification rates. While these differences did not translate in species-specific responses to short-term OA exposure, the differences in the magnitude of diurnal pH fluctuations (~ 0.1–1.2 pH units) between species suggest potential differences in phenotypic plasticity to OA that may result in different susceptibilities to long-term OA exposure, supporting the general view that species’ ecomechanical characteristics must be considered for predicting OA responses.

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Emerging contaminants:A One Health perspective

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The Innovation 2024年第4期5卷 140-170,139页

作者： Fang Wang Leilei Xiang Kelvin Sze-Yin Leung Martin Elsner Ying Zhang Yuming Guo Bo Pan Hongwen Sun Taicheng An Guangguo Ying Bryan WBrooks Deyi Hou Damian EHelbling Jianqiang Sun Hao Qiu Timothy MVogel Wei Zhang Yanzheng Gao Myrna JSimpson Yi Luo Scott XChang Guanyong Su Bryan MWong Tzung-May Fu Dong Zhu Karl JJobst Chengjun Ge Frederic Coulon Jean Damascene Harindintwali Xiankui Zeng Haijun Wang Yuhao Fu Zhong Wei Rainer Lohmann Changer Chen Yang Song Concepcion Sanchez-Cid Yu Wang Ali El-Naggar Yiming Yao Yanran Huang Japhet Cheuk-Fung Law Chenggang Gu Huizhong Shen Yanpeng Gao Chao Qin Hao Li Tong Zhang Natàlia Corcoll Min Liu Daniel SAlessi Hui Li Kristian KBrandt Yolanda Pico Cheng Gu Jianhua Guo Jianqiang Su Philippe Corvini Mao Ye Teresa Rocha-Santos Huan He Yi Yang Meiping Tong Weina Zhang Fidèle Suanon Ferdi Brahushi Zhenyu Wang Syed AHashsham Marko Virta Qingbin Yuan Gaofei Jiang Louis A.Tremblay Qingwei Bu Jichun Wu Willie Peijnenburg Edward Topp Xinde Cao Xin Jiang Minghui Zheng Taolin Zhang Yongming Luo Lizhong Zhu Xiangdong Li DamiàBarceló Jianmin Chen Baoshan Xing Wulf Amelung Zongwei Cai Ravi Naidu Qirong Shen Janusz Pawliszyn Yong-guan Zhu Andreas Schaeffer Matthias C.Rillig Fengchang Wu Gang Yu James M.Tiedje State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China University of Chinese Academy of Sciences Beijing 100049China Department of Chemistry Hong Kong Baptist UniversityHong KongChina HKBU Institute of Research and Continuing Education Shenzhen Virtual University ParkShenzhenChina Technical University of Munich TUM School of Natural SciencesInstitute of Hydrochemistry85748 GarchingGermany School of Resources&Environment Northeast Agricultural UniversityHarbin 150030China Climate Air Quality Research UnitSchool of Public Health and Preventive MedicineMonash UniversityMelbourneVICAustralia Faculty of Environmental Science&Engineering Kunming University of Science&TechnologyKunming 650500China Ministry of Education Key Laboratory of Pollution Processes and Environmental Criteria College of Environmental Science and EngineeringNankai UniversityTianjin 300350China Guangdong Key Laboratory of Environmental Catalysis and Health Risk Control School of Environmental Science and EngineeringInstitute of Environmental Health and Pollution ControlGuangdong University of TechnologyGuangzhou 510006China Ministry of Education Key Laboratory of Environmental Theoretical Chemistry South China Normal UniversityGuangzhouGuangdong 510006China Department of Environmental Science Baylor UniversityWacoTXUSA Center for Reservoir and Aquatic Systems Research(CRASR) Baylor UniversityWacoTXUSA School of Environment Tsinghua UniversityBeijing 100084China School of Civil and Environmental Engineering Cornell UniversityIthacaNY 14853USA Key Laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province Zhejiang University of TechnologyHangzhou 310014China School of Environmental Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China Laboratoire d’Ecologie Microbienne Universite Claude Bernard Lyon 1UMR CNRS 5557UMR INRAE 1418VetAgro Sup69622 VilleurbanneFrance Department of Pla

Environmental pollution is escalating due to rapid global development that often prioritizes human needs over planetary *** global efforts to mitigate legacy pollutants,the continuous introduction of new substances remains a major threat to both people and the *** response,global initiatives are focusing on risk assessment and regulation of emerging contaminants,as demonstrated by the ongoing efforts to establish the UN’s Intergovernmental Science-Policy Panel on Chemicals,Waste,and Pollution *** review identifies the sources and impacts of emerging contaminants on planetary health,emphasizing the importance of adopting a One Health *** for monitoring and addressing these pollutants are discussed,underscoring the need for robust and socially equitable environmental policies at both regional and international *** actions are needed to transition toward sustainable pollution management practices to safeguard our planet for future generations.

关键词： pollution planet contaminants

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A micromirror array with annular partitioning for high-speed random-access axial focusing

arXiv

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arXiv 2020年

作者： Ersumo, Nathan Tessema Yalcin, Cem Antipa, Nick Pégard, Nicolas Waller, Laura Lopez, Daniel Muller, Rikky University of California Berkeley - University of California San Francisco Graduate Program in Bioengineering United States Departement of Electrical Engineering & Computer Sciences University of California BerkeleyCA94720 United States Department of Applied Physical Sciences University of North Carolina at Chapel Hill Chapel HillNC27514 United States Chan Zuckerberg Biohub San FranciscoCA94158 United States Physical Measurement Laboratory National Institute of Standards and Technology GaithersburgMD20899 United States

Dynamic axial focusing functionality has recently seen widespread incorporation in microscopy, augmented/virtual reality (AR/VR), adaptive optics, and material processing. Yet the limitations of existing varifocal tools continue to beset the performance capabilities and operating overhead of the optical systems that mobilize such functionality. The varifocal tools that are the least burdensome to drive (ex: liquid crystal, elastomeric or optofluidic lenses) suffer from low (~100 Hz) refresh rates. Conversely, the fastest devices sacrifice either critical capabilities such as dwelling capacity (ex: acoustic gradient lenses or monolithic micromechanical mirrors) or low operating overhead (ex: deformable mirror arrays). Here, we present a general-purpose random-access axial focusing device that bridges these previously conflicting features of high speed, dwelling capacity and lightweight drive by employing low-rigidity micromirrors that exploit the robustness of defocusing phase profiles. Geometrically, the device consists of an 8.2 mm diameter array of piston-motion, 48 μm-pitch micromirror pixels that provide 2π phase shifting for wavelengths shorter than 1 100 nm with 10-90% settling in 64.8 μs (i.e. 15.44 kHz refresh rate). The pixels are electrically partitioned into 32 rings for a driving scheme that enables phase-wrapped operation with circular symmetry and requires less than 30 V/channel. Optical experiments demonstrated the array’s wide focusing range with a measured ability to target 29 distinct, resolvable depth planes. Overall, the features of the proposed array offer the potential for compact, straightforward methods of tackling bottlenecked applications including high-throughput single-cell targeting in neurobiology and the delivery of dense 3D visual information in AR/VR. Copyright © 2020, The Authors. All rights reserved.

关键词： Pixels

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Bridging between type IIb and Ib supernovae: SN IIb 2022crv with a very thin Hydrogen envelope

arXiv

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arXiv 2023年

作者： Gangopadhyay, Anjasha Maeda, Keiichi Singh, Avinash Nayana, A.J. Nakaoka, Tatsuya Kawabata, Koji S. Taguchi, Kenta Singh, Mridweeka Chandra, Poonam Ryder, Stuart D. Dastidar, Raya Yamanaka, Masayuki Kawabata, Miho Alsaberi, Rami Z.E. Dukiya, Naveen Teja, Rishabh Singh Ailawadhi, Bhavya Dutta, Anirban Sahu, D.K. Moriya, Takashi J. Misra, Kuntal Tanaka, Masaomi Chevalier, Roger Tominaga, Nozomu Uno, Kohki Imazawa, Ryo Hamada, Taisei Hori, Tomoya Isogai, Keisuke Hiroshima Astrophysical Science Centre Hiroshima University 1-3-1 Kagamiyama Higashi-Hiroshima Hiroshima739-8526 Japan Department of Astronomy Kyoto University Kitashirakawa-Oiwake-cho Sakyo-ku Kyoto606-8502 Japan Indian Institute of Astrophysics Koramangala 2nd Block Bangalore560034 India Department of Physics Graduate School of Advanced Science and Engineering Hiroshima University 1-3-1 Kagamiyama Higashi-Hiroshima Hiroshima739-8526 Japan National Radio Astronomy Observatory 520 Edgemont Road CharlottesvilleVA22903 United States School of Mathematical and Physical Sciences Macquarie University NSW2109 Australia Astrophysics and Space Technologies Research Centre Macquarie University SydneyNSW2109 Australia Instituto de Astrofísica Universidad Andres Bello Fernandez Concha 700 Las Condes RM Santiago Chile Millennium Institute of Astrophysics Nuncio Monsenor Sótero Sanz 100 Providencia Santiago8320000 Chile Graduate School of Science and Engineering Kagoshima University 1-21-35 Korimoto Kagoshima Kagoshima890-0065 Japan Nishi-Harima Astronomical Observatory Center for Astronomy University of Hyogo 407-2 Nishigaichi Sayo-cho Hyogo Sayo679-5313 Japan Western Sydney University Locked Bag 1797 PenrithNSW2751 Australia Aryabhatta Research Institute of observational sciencES Manora Peak Nainital263 002 India Department of Applied Physics Mahatma Jyotiba Phule Rohilkhand University Bareilly243006 India Pondicherry University Chinna Kalapet Puducherry Kalapet605014 India Department of Physics Deen Dayal Upadhyaya Gorakhpur University Gorakhpur273009 India National Astronomical Observatory of Japan National Institutes of Natural Sciences 2-21-1 Osawa Mitaka Tokyo181-8588 Japan School of Physics and Astronomy Faculty of Science Monash University ClaytonVIC3800 Australia Astronomical Institute Tohoku University Aoba Sendai980-8578 Japan University Of Virginia Astronomy Building 530 McCormick Road CharlottesvilleVA2290

We present optical, near-infrared, and radio observations of supernova (SN) SN IIb 2022crv. We show that it retained a very thin H envelope and transitioned from a SN IIb to a SN Ib;prominent Hα seen in the pre-maximum phase diminishes toward the post-maximum phase, while He i lines show increasing strength. SYNAPPS modeling of the early spectra of SN 2022crv suggests that the absorption feature at 6200 Å is explained by a substantial contribution of Hα together with Si ii, as is also supported by the velocity evolution of Hα. The light-curve evolution is consistent with the canonical stripped-envelope supernova subclass but among the slowest. The light curve lacks the initial cooling phase and shows a bright main peak (peak MV =−17.82±0.17 mag), mostly driven by radioactive decay of 56Ni. The light-curve analysis suggests a thin outer H envelope (Menv ∼0.05 M☉) and a compact progenitor (Renv ∼3 R☉). An interaction-powered synchrotron self-absorption (SSA) model can reproduce the radio light curves with a mean shock velocity of 0.1c. The mass-loss rate is estimated to be in the range of (1.9−2.8) × 10−5 M☉ yr−1 for an assumed wind velocity of 1000 km s−1, which is on the high end in comparison with other compact SNe IIb/Ib. SN 2022crv fills a previously unoccupied parameter space of a very compact progenitor, representing a beautiful continuity between the compact and extended progenitor scenario of SNe IIb/Ib. Copyright © 2023, The Authors. All rights reserved.

关键词： Supernovae

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Low energy performance boost through a hardware stereoscopic trigger between CTA LST-1 and MAGIC 38

Low energy performance boost through a hardware stereoscopic...

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38th International Cosmic Ray Conference, ICRC 2023

作者： Baxter, J. Barrio, J.A. Bitossi, M. Donini, A. Mazin, D. Paoletti, R. Pérez Aguilera, A. Tejedor Álvarez, L.Á. Abe, H. Abe, K. Abe, S. Abhir, J. Acciari, V.A. Aguasca-Cabot, A. Agudo, I. Alvarez Crespo, N. Aniello, T. Ansoldi, S. Antonelli, L.A. Aramo, C. Arbet-Engels, A. Cornelia, A. Artero, M. Asano, K. Aubert, P. Baack, D. Babić, A. Baktash, A. Bamba, A. Baquero Larriva, A. Baroncelli, L. Barres de Almeida, U. Barrio, J.A. Batkovic, I. Becerra González, J. Bednarek, W. Bernardini, E. Bernardos, M.I. Bernete Medrano, J. Berti, A. Besenrieder, J. Bhattacharjee, P. Biederbeck, N. Bigongiari, C. Biland, A. Bissaldi, E. Blanch, O. Bonnoli, G. Bordas, P. Bošnjak, Ž. Bulgarelli, A. Burelli, I. Burmistrov, L. Buscemi, M. Busetto, G. Campoy-Ordaz, A. Cardillo, M. Caroff, S. Carosi, A. Carosi, R. Carrasco, M.S. Carretero-Castrillo, M. Cassol, F. Castro-Tirado, A.J. Cauz, D. Cerasole, D. Ceribella, G. Chai, Y. Cheng, K. Chiavassa, A. Chikawa, M. Chilingarian, A. Chytka, L. Cifuentes, A. Cikota, S. Colombo, E. Contreras, J.L. Cortina, J. Costantini, H. Covino, S. D’Amico, G. Dalchenko, M. D’Elia, V. Da Vela, P. Dazzi, F. De Angelis, A. de Bony de Lavergne, M. De Lotto, B. De Lucia, M. de Menezes, R. Del Peral, L. Deleglise, G. Delfino, M. Delgado, C. Delgado Mengual, J. della Volpe, D. Dellaiera, M. Del Popolo, A. Depaoli, D. Di Piano, A. Di Pierro, F. Di Pilato, A. Di Tria, R. Di Venere, L. Díaz, C. Dominik, R.M. Dominis Prester, D. Donini, A. Dorner, D. Doro, M. Eisenberger, L. Elsässer, D. Emery, G. Escudero, J. Fallah Ramazani, V. Fariña, L. Fattorini, A. Ferrara, G. Ferrarotto, F. Fiasson, A. Foffano, L. Font, L. Freixas Coromina, L. Fröse, S. Fukami, S. Fukazawa, Y. Garcia, E. Garcia López, R. Garczarczyk, M. Gasbarra, C. Gasparrini, D. Gasparyan, S. Gaug, M. Geyer, D. Giesbrecht Paiva, J. Giglietto, N. Giordano, F. Gliwny, P. Godinovic, N. Grau, R. Green, J. Green, D. Gunji, S. Günther, P. Hackfeld, J. Hadasch, D. Hahn, A. Hashiyama, K. Hassan, T. Hayashi, K. Institute for Cosmic Ray Research University of Tokyo Chiba Kashiwa277-8582 Japan IPARCOS Institute EMFTEL Department Universidad Complutense de Madrid Spain Sezione di Pisa Pisa56127 Italy Osservatorio Astronomico di Roma Italy Max-Planck-Institut für Physik Föhringer Ring 6 München80805 Germany Università degli Studi di Siena via Roma 56 Siena53100 Italy Department of Physics Tokai University Japan ETH Zürich Switzerland Instituto de Astrofísica de Canarias Departamento de Astrofísica Universidad de La Laguna Spain Departament de Física Quàntica i Astrofísica Institut de Ciències del Cosmos Universitat de Barcelona IEEC-UB Spain Instituto de Astrofísica de Andalucía-CSIC Spain EMFTEL department IPARCOS Universidad Complutense de Madrid Spain Italy INFN Sezione di Trieste Università degli Studi di Udine Italy Italy INAF Osservatorio Astronomico di Roma Italy INFN Sezione di Napoli Italy INFN Sezione di Padova Università degli Studi di Padova Italy The Barcelona Institute of Science and Technology Spain LAPP Univ. Grenoble Alpes Univ. Savoie Mont Blanc CNRS-IN2P3 Annecy France Department of Physics TU Dortmund University Germany Croatia Universität Hamburg Institut für Experimentalphysik Germany Graduate School of Science University of Tokyo Japan Universidad del Azuay Ecuador INAF Osservatorio di Astrofisica e Scienza dello spazio di Bologna Italy Centro Brasileiro de Pesquisas Físicas Brazil Faculty of Physics and Applied Informatics University of Lodz Poland CIEMAT Spain INFN Sezione di Bari Politecnico di Bari Italy INAF Osservatorio Astronomico di Brera Italy University of Geneva Département de physique nucléaire et corpusculaire Switzerland INFN Sezione di Catania Italy Departament de Física CERES-IEEC Universitat Autónoma de Barcelona Spain Italy Università di Pisa INFN Pisa Italy Aix Marseille Univ CNRS IN2P3 CPPM France INFN Sezione di Bari Università di Bari Italy INFN Sezione di Torino Italy ICRANet-Armenia at

The next generation facility for gamma-ray ground-based observations is the Cherenkov Telescope Array (CTA) observatory, which comprises three types of imaging atmospheric Cherenkov telescopes (IACTs). The Large-Sized Telescopes (LSTs) of CTA are the largest telescope type with a mirror dish of 23 m diameter. They cover the low energy end of the accessible gamma-ray energies for IACTs, starting from about 20 GeV up to a few TeV. The first LST prototype, known as LST-1, was officially inaugurated at the Observatorio del Roque de Los Muchachos in La Palma (Canary Islands, Spain) in 2018 and has since performed calibration observations of various known gamma-ray sources. Additionally, the site houses the MAGIC telescopes, two 17 m IACTs situated approximately 100 m away from LST-1, which have been performing stereo observations since 2009. Currently, joint observations between LST-1 and MAGIC are being carried on, and the data taken independently by the two IACT systems is analyzed by combining events via software. However, this method increases the energy threshold, as it discards all but the relatively high-energy events triggered by all three telescopes. To address this issue, we have developed a novel hardware stereo trigger system between LST-1 and MAGIC, which is capable of handling events triggered by any-two out of the three telescopes. In this contribution, we will report on the performance estimation of joint LST-1 and MAGIC observations using the hardware trigger. © Copyright owned by the author(s) under the terms of the Creative Commons.

关键词： Cosmology

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Observation of Active Galactic Nuclei with the Large-Sized Telescope prototype of the Cherenkov Telescope Array 38

Observation of Active Galactic Nuclei with the Large-Sized T...

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38th International Cosmic Ray Conference, ICRC 2023

作者： Takeishi, R. Álvarez Crespo, N. Arbet-Engels, A. Baquero Larriva, A. Baxter, J. Biederbeck, N. Caroff, S. Di Marco, G. Fallah Ramazani, V. Green, D. Heckmann, L. Láinez, M. Nickel, L. Nievas Rosillo, M. Pons, E. Priyadarshi, C. Sanchez, D.A. Vázquez Acosta, M. Abe, K. Abe, S. Aguasca-Cabot, A. Agudo, I. Antonelli, L.A. Aramo, C. Arcaro, C. Artero, M. Asano, K. Aubert, P. Baktash, A. Bamba, A. Baquero Larriva, A. Baroncelli, L. Barres de Almeida, U. Barrio, J.A. Batkovic, I. Becerra González, J. Bernardini, E. Bernardos, M.I. Bernete Medrano, J. Berti, A. Bhattacharjee, P. Bigongiari, C. Bissaldi, E. Blanch, O. Bonnoli, G. Bordas, P. Bulgarelli, A. Burelli, I. Burmistrov, L. Buscemi, M. Cardillo, M. Carosi, A. Carrasco, M.S. Cassol, F. Cauz, D. Cerasole, D. Ceribella, G. Chai, Y. Cheng, K. Chiavassa, A. Chikawa, M. Chytka, L. Cifuentes, A. Contreras, J.L. Cortina, J. Costantini, H. Dalchenko, M. Dazzi, F. De Angelis, A. de Bony de Lavergne, M. De Lotto, B. De Lucia, M. de Menezes, R. Del Peral, L. Deleglise, G. Delgado, C. Delgado Mengual, J. della Volpe, D. Dellaiera, M. Di Piano, A. Di Pierro, F. Di Pilato, A. Di Tria, R. Di Venere, L. Díaz, C. Dominik, R.M. Dominis Prester, D. Donini, A. Dorner, D. Doro, M. Eisenberger, L. Elsässer, D. Emery, G. Escudero, J. Ferrara, G. Ferrarotto, F. Fiasson, A. Foffano, L. Freixas Coromina, L. Fröse, S. Fukami, S. Fukazawa, Y. Garcia, E. Garcia López, R. Gasbarra, C. Gasparrini, D. Geyer, D. Giesbrecht Paiva, J. Giglietto, N. Giordano, F. Gliwny, P. Godinovic, N. Grau, R. Gunji, S. Günther, P. Hackfeld, J. Hadasch, D. Hahn, A. Hashiyama, K. Hassan, T. Hayashi, K. Heller, M. HerreraLlorente, J. Hirotani, K. Hoffmann, D. Horns, D. Houles, J. Hrabovsky, M. Hrupec, D. Hui, D. Hütten, M. Iarlori, M. Imazawa, R. Inada, T. Inome, Y. Ioka, K. Iori, M. Ishio, K. Jimenez Martinez, I. Jurysek, J. Kagaya, M. Karas, V. Katagiri, H. Kataoka, J. Kerszberg, D. Kobayashi, Y. Kohri, K. Kong, A. Kubo, H. Kushida, J. Lamanna, G. Lamastra, A. Institute for Cosmic Ray Research University of Tokyo Chiba Kashiwa277-8582 Japan Grupo de Electronica Universidad Complutense de Madrid Av. Complutense s/n Madrid28040 Spain Max-Planck-Institut für Physik Föhringer Ring 6 München80805 Germany IPARCOS-UCM Instituto de Física de Partículas y del Cosmos EMFTEL Department Universidad Complutense de Madrid MadridE-28040 Spain Faculty of Science and Technology Universidad del Azuay Cuenca Ecuador Department of Physics TU Dortmund University Otto-Hahn-Str. 4 Dortmund44227 Germany Univ. Savoie Mont Blanc CNRS Laboratoire d’Annecy de Physique des Particules - IN2P3 Annecy74000 France Instituto de Astrofísica de Canarias Departamento de Astrofísica Universidad de La Laguna Tenerife La Laguna Spain Institut für Theoretische Physik Lehrstuhl IV: Plasma-Astroteilchenphysik Ruhr-Universität Bochum Universitätsstraße 150 Bochum44801 Germany The Barcelona Institute of Science and Technology Campus UAB Bellaterra Barcelona08193 Spain Department of Physics Tokai University Japan Departament de Física Quàntica i Astrofísica Institut de Ciències delCosmos Universitat de Barcelona IEEC-UB Spain Instituto de Astrofísica de Andalucía-CSIC Spain EMFTEL department IPARCOS Universidad Complutense de Madrid Spain INAF - Osservatorio Astronomico di Roma Italy INFN Sezione di Napoli Italy INFN Sezione di Padova Università degli Studi di Padova Italy Universität Hamburg Institut für Experimentalphysik Germany Graduate School of Science University of Tokyo Japan Universidad del Azuay Ecuador INAF - Osservatorio di Astrofisica e Scienza dello spazio di Bologna Italy Centro Brasileiro de Pesquisas Físicas Brazil CIEMAT Spain INFN Sezione di Bari Politecnico di Bari Italy INAF - Osservatorio Astronomico di Brera Italy INFN Sezione di Trieste Università degli Studi di Udine Italy University of Geneva Département de physique nucléaire et corpusculaire Switzerland INFN Sezione di Catania Italy Italy Aix Marseille Uni

Cherenkov Telescope Array (CTA) will be the next generation gamma-ray observatory. It will consist of three different sizes of telescopes, with a collective improvement of about an order of magnitude in sensitivity, compared with the current generation gamma-ray telescopes. LargeSized Telescopes (LSTs) will be the most sensitive at energies from tens of GeV up to a few TeVs, and will be the best suited to observe gamma-ray sources such as Active Galactic Nuclei (AGN). The first Large-Sized Telescope prototype (LST-1), inaugurated in 2018 and currently in commissioning phase, has accumulated more than one thousand hours of data to date. From 2020 to 2022, we have detected various gamma-ray sources, and prominent among them are several well-known AGN, like Mrk 421, Mrk 501, 1ES 1959+650, 1ES 0647+250, PG 1553+113, etc. We report on light curves and energy spectra reconstructed out of these observations down to energies of tens of GeV, which is very close to the energy threshold of LST-1. © Copyright owned by the author(s) under the terms of the Creative Commons.

关键词： Active Galactic Nuclei

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Hypoxia-responsive circular RNA circAAGAB reduces breast cancer malignancy by activating p38 MAPK and sponging miR-378 h

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Cancer cell international 2023年第1期23卷 45页

作者： Kuan-Yi Lee Chia-Ming Liu Li-Han Chen Chien-Yueh Lee Tzu-Pin Lu Li-Ling Chuang Liang-Chuan Lai Graduate Institute of Physiology College of Medicine National Taiwan University Taipei Taiwan. Institute of Fisheries Science College of Life Science National Taiwan University Taipei Taiwan. Department of Life Science College of Life Science National Taiwan University Taipei Taiwan. Master Program for Biomedical Engineering College of Biomedical Engineering China Medical University Taichung Taiwan. Institute of Epidemiology and Preventive Medicine Department of Public Health National Taiwan University Taipei Taiwan. School of Physical Therapy and Graduate Institute of Rehabilitation Science College of Medicine Chang Gung University Taoyuan Taiwan. lchuang@gap.cgu.edu.tw. Department of Physical Medicine and Rehabilitation Chang Gung Memorial Hospital at Linkou Taoyuan Taiwan. lchuang@gap.cgu.edu.tw. Graduate Institute of Physiology College of Medicine National Taiwan University Taipei Taiwan. llai@ntu.edu.tw. Bioinformatics and Biostatistics Core Center of Genomic and Precision Medicine National Taiwan University Taipei Taiwan. llai@ntu.edu.tw.

BACKGROUND:Breast cancer is a prevalent disease in women, with high prevalence worldwide. The hypoxic microenvironment of solid tumors develops during the progress of carcinogenesis and leads to greater malignancy and treatment resistance. Recently, accumulating evidence indicates that non-coding RNAs, such as circular RNAs (circRNAs), play a pivotal role in altering cellular functions. However, the underlying mechanisms of circRNAs in breast cancer are still unclear. Therefore, the purpose of this study was to investigate the role of a tumor-suppressive circRNA, circAAGAB, in breast cancer by assuming down-regulation of circAAGAB under hypoxia and the properties of a tumor suppressor. METHODS:Firstly, circAAGAB was identified from expression profiling by next generation sequencing. Next, the stability of circAAGAB increased by interacting with the RNA binding protein FUS. Moreover, cellular and nuclear fractionation showed that most circAAGAB resided in the cytoplasm and that it up-regulated KIAA1522, NKX3-1, and JADE3 by sponging miR-378 h. Lastly, the functions of circAAGAB were explored by identifying its down-stream genes using Affymetrix microarrays and validated by in vitro assays. RESULTS:The results showed that circAAGAB reduced cell colony formation, cell migration, and signaling through p38 MAPK pathway, as well as increased radiosensitivity. CONCLUSION:These findings suggest that the oxygen-responsive circAAGAB acts as a tumor suppressor in breast cancer, and may contribute to the development of a more specific therapeutic regimen for breast cancer.

关键词： Breast cancer Hypoxia Radiosensitivity Tumor suppressor circAAGAB miRNA sponge p38 MAPK

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Correction: Autonomy support encourages use of more-afected arm post-stroke

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Journal of neuroengineering and rehabilitation 2023年第1期20卷 126页

作者： Sujin Kim Yumi Shin Yeonwoo Jeong Seungyoung Na Cheol E Han Department of Physical Therapy Jeonju University Jeonju South Korea. Department of Rehabilitative and Assistive Technology National Rehabilitation Center Seoul South Korea. Department of Rehabilitation and Medicine Ongoul Rehabilitation Hospital Jeonju South Korea. Department of Electronics and Information Engineering Korea University Sejong South Korea. cheolhan@korea.ac.kr. Interdisciplinary Graduate Program for Artificial Intelligence Smart Convergence Technology Korea University Sejong South Korea. cheolhan@korea.ac.kr.

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cytoNet: Network Analysis of Cell Communities

SSRN

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SSRN 2019年

作者： Mahadevan, Arun S. Long, Byron L. Hu, Chenyue Wendy Ryan, David T. Britton, George L. Ligeralde, Andrew Robinson, Jacob T. Warmflash, Aryeh Qutub, Amina Ann Department of Biomedical Engineering University of Pennsylvania Department of Biomedical Engineering University of Texas San Antonio United States Department of Bioengineering Rice University Systems Synthetic and Physical Biology Program Rice University Department of Electrical and Computer Engineering Rice University The Department of Biosciences Rice University Biophysics Graduate Program University of California Berkeley United States

We introduce cytoNet, a method to characterize multicellular topology from microscopy images. Accessible through a web-based interface, cytoNet quantifies the spatial relationships in cell communities using principles of graph theory, and evaluates the effect of cell-cell interactions on individual cell phenotypes. We demonstrate cytoNet’s capabilities in two applications relevant to regenerative medicine: quantifying the morphological response of endothelial cells to neurotrophic factors present in the brain after injury, and characterizing cell cycle dynamics of differentiating neural progenitor cells. The framework introduced here can be used to study complex cell communities in a quantitative manner, leading to a deeper understanding of environmental effects on cellular behavior. © 2019, The Authors. All rights reserved.

关键词： Endothelial cells

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Joint Observation of the Galactic Center with MAGIC and CTA-LST-1 38

Joint Observation of the Galactic Center with MAGIC and CTA-...

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38th International Cosmic Ray Conference, ICRC 2023

作者： Abe, Shotaro Berti, Alessio Di Pierro, Federico López-Coto, Rubén Moralejo, Abelardo Ohtani, Yoshiki Sitarek, Julian Strzys, Marcel Suda, Yusuke Vovk, Ievgen Abe, H. Abe, K. Abe, S. Abhir, J. Acciari, V.A. Aguasca-Cabot, A. Agudo, I. Alvarez Crespo, N. Aniello, T. Ansoldi, S. Antonelli, L.A. Aramo, C. Arbet-Engels, A. Cornelia, A. Artero, M. Asano, K. Aubert, P. Baack, D. Babić, A. Baktash, A. Bamba, A. Baquero Larriva, A. Baroncelli, L. Barres de Almeida, U. Barrio, J.A. Batkovic, I. Baxter, J. Becerra González, J. Bednarek, W. Bernardini, E. Bernardos, M.I. Bernete Medrano, J. Berti, A. Besenrieder, J. Bhattacharjee, P. Biederbeck, N. Bigongiari, C. Biland, A. Bissaldi, E. Blanch, O. Bonnoli, G. Bordas, P. Bošnjak, Ž. Bulgarelli, A. Burelli, I. Burmistrov, L. Buscemi, M. Busetto, G. Campoy-Ordaz, A. Cardillo, M. Caroff, S. Carosi, A. Carosi, R. Carrasco, M.S. Carretero-Castrillo, M. Cassol, F. Castro-Tirado, A.J. Cauz, D. Cerasole, D. Ceribella, G. Chai, Y. Cheng, K. Chiavassa, A. Chikawa, M. Chilingarian, A. Chytka, L. Cifuentes, A. Cikota, S. Colombo, E. Contreras, J.L. Cortina, J. Costantini, H. Covino, S. D’Amico, G. Dalchenko, M. D’Elia, V. Da Vela, P. Dazzi, F. De Angelis, A. de Bony de Lavergne, M. De Lotto, B. De Lucia, M. de Menezes, R. Del Peral, L. Deleglise, G. Delfino, M. Delgado, C. Delgado Mengual, J. della Volpe, D. Dellaiera, M. Del Popolo, A. Depaoli, D. Di Piano, A. Di Pierro, F. Di Pilato, A. Di Tria, R. Di Venere, L. Díaz, C. Dominik, R.M. Dominis Prester, D. Donini, A. Dorner, D. Doro, M. Eisenberger, L. Elsässer, D. Emery, G. Escudero, J. Fallah Ramazani, V. Fariña, L. Fattorini, A. Ferrara, G. Ferrarotto, F. Fiasson, A. Foffano, L. Font, L. Freixas Coromina, L. Fröse, S. Fukami, S. Fukazawa, Y. Garcia, E. Garcia López, R. Garczarczyk, M. Gasbarra, C. Gasparrini, D. Gasparyan, S. Gaug, M. Geyer, D. Giesbrecht Paiva, J. Giglietto, N. Giordano, F. Gliwny, P. Godinovic, N. Grau, R. Green, J. Green, D. Gunji, S. Günther, P. Hackfeld, J. Hadasch, D. Hahn, A. Institute for Cosmic Ray Research Kashiwa-no-ha 5-1-5 Kashiwa-shi Chiba Japan Max-Planck-Institut für Physik Föhringer Ring 6 München80805 Germany INFN Sezione di Torino Via P. Giuria 1 Torino10125 Italy Instituto de Astrofísica de Andalucía-CSIC Glorieta de la Astronomía s/n Granada18008 Spain The Barcelona Institute of Science and Technology Campus UAB Bellaterra Barcelona08193 Spain Faculty of Physics and Applied Informatics University of Lodz ul. Pomorska 149-153 Lodz90-236 Poland Physics Program Graduate School of Advanced Science and Engineering Hiroshima University Hiroshima739-8526 Japan Institute for Cosmic Ray Research University of Tokyo Japan Department of Physics Tokai University Japan ETH Zürich Switzerland Instituto de Astrofísica de Canarias Departamento de Astrofísica Universidad de La Laguna Spain Departament de Física Quàntica i Astrofísica Institut de Ciències del Cosmos Universitat de Barcelona IEEC-UB Spain EMFTEL department IPARCOS Universidad Complutense de Madrid Spain Italy INFN Sezione di Trieste Università degli Studi di Udine Italy Italy INAF Osservatorio Astronomico di Roma Italy INFN Sezione di Napoli Italy INFN Sezione di Padova Università degli Studi di Padova Italy LAPP Univ. Grenoble Alpes Univ. Savoie Mont Blanc CNRS-IN2P3 Annecy France Department of Physics TU Dortmund University Germany Croatia Universität Hamburg Institut für Experimentalphysik Germany Graduate School of Science University of Tokyo Japan Universidad del Azuay Ecuador INAF Osservatorio di Astrofisica e Scienza dello spazio di Bologna Italy Centro Brasileiro de Pesquisas Físicas Brazil CIEMAT Spain INFN Sezione di Bari Politecnico di Bari Italy INAF Osservatorio Astronomico di Brera Italy University of Geneva Département de physique nucléaire et corpusculaire Switzerland INFN Sezione di Catania Italy Departament de Física CERES-IEEC Universitat Autónoma de Barcelona Spain Italy Università di Pisa INFN Pisa Italy Aix Mars

MAGIC is a system of two Imaging Atmospheric Cherenkov Telescopes (IACTs), designed to detect very-high-energy gamma rays, and is operating in stereoscopic mode since 2009 at the Observatorio del Roque de Los Muchachos in La Palma, Spain. In 2018, the prototype IACT of the Large-Sized Telescope (LST-1) for the Cherenkov Telescope Array, a next-generation ground-based gamma-ray observatory, was inaugurated at the same site, at a distance of approximately 100 meters from the MAGIC telescopes. Using joint observations between MAGIC and LST-1, we developed a dedicated analysis pipeline and established the threefold telescope system via software, achieving the highest sensitivity in the northern hemisphere. Based on this enhanced performance, MAGIC and LST-1 have been jointly and regularly observing the Galactic Center, a region of paramount importance and complexity for IACTs. In particular, the gamma-ray emission from the dynamical center of the Milky Way is under debate. Although previous measurements suggested that a supermassive black hole Sagittarius A* plays a primary role, its radiation mechanism remains unclear, mainly due to limited angular resolution and sensitivity. The enhanced sensitivity in our novel approach is thus expected to provide new insights into the question. We here present the current status of the data analysis for the Galactic Center joint MAGIC and LST-1 observations. © Copyright owned by the author(s) under the terms of the Creative Commons.

关键词： Cosmology

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