检索结果-内蒙古大学图书馆

arXiv 2024年

作者： Zheng, Yitong Wang, Dong Beeghly, Garrett Fischbach, Claudia Shattuck, Mark D. O’Hern, Corey S. Department of Mechanical Engineering & Materials Science Yale University New HavenCT06520 United States Integrated Graduate Program in Physical and Engineering Biology Yale University New HavenCT06520 United States Nancy E. and Peter C. Meinig School of Biomedical Engineering Cornell University IthacaNY14853 United States Benjamin Levich Institute Physics Department City College of New York New YorkNY10031 United States Department of Physics Yale University New HavenCT06520 United States

Breast cancer invasion into adipose tissue strongly influences disease progression and metastasis. The degree of cancer cell invasion into adipose tissue depends on numerous biochemical and physical properties of cancer cells, adipocytes, and other key components of adipose tissue. We model breast cancer invasion into adipose tissue as a physical process by carrying out simulations of active, cohesive spherical particles (cancer cells) invading into confluent packings of deformable polyhedra (adipocytes). We quantify the degree of invasion by calculating the interfacial area At between cancer cells and adipocytes. We determine the long-time value of At versus the activity and strength of the cohesion between cancer cells, as well as mechanical properties of the adipocytes and extracellular matrix (ECM) in which the adipocytes are embedded. We show that the degree of invasion collapses onto a master curve by plotting it versus a dimensionless energy scale Ec, which grows linearly with mean-square fluctuations and persistence time of the cancer cell velocities, is inversely proportional to the pressure of the system, and has an offset that increases with the cancer cell cohesive energy. The condition, Ec 1, indicates that cancer cells will invade the adipose tissue, whereas for Ec 1, the cancer cells and adipocytes remain demixed. We also show that constraints on adipocyte positions by the ECM decrease At relative to that obtained for unconstrained adipocytes. Finally, spatial heterogeneity in structural and mechanical properties of the adipocytes in the presence of ECM impedes invasion relative to adipose tissue with uniform properties. © 2024, CC BY-NC-ND.

关键词： Cancer cells

来源：评论

学校读者我要写书评

暂无评论

Transforming Near-Infrared Photodetectors with Perovskites: Materials, Strategies, and Future Outlook

引用

Energy and Fuels 2025年第23期39卷 10744-10767页

作者： Xu, Ruizhi Chin, Xin Yu White, Luke R. W. Mhaisalkar, Subodh G. Bruno, Annalisa Energy Research Institute @ NTU Nanyang Technological University Research Techno Plaza 50 Nanyang Drive Singapore 637553 Singapore Interdsciplinary Graduate Program Nanyang Technological University Singapore 637553 Singapore School of Physical and Mathematical Science Nanyang Technological University 21 Nanyang Link Singapore 637371 Singapore School of Materials Science and Engineering Nanyang Technological University 50 Nanyang Avenue Singapore 639798 Singapore SKKU Institute of Energy Science and Technology (SIEST) Sungkyunkwan University 2066 Seobu-ro Jangan-gu Gyeonggi-do Suwon-si 16419 South Korea

Photodetectors, capable of transforming optical stimuli to electrical signals, have experienced unprecedented growth in their development recently due to rapidly growing demand in sensing, imaging, and communication. Particularly, near-infrared (NIR) photodetectors garnered much attention for decades for their sophisticated applications, including advanced imaging of energy dissipation, solar spectrum monitoring, biomedical imaging, optical communication, environmental monitoring, augmented reality, etc. In an effort to obtain better photodetector performance in the NIR region, various inorganic material platforms have been explored, spanning traditional inorganic semiconductors exemplified by silicon, germanium, III-V materials, low-dimensional materials, polymers, and their heterostructures. Although conventional inorganic photodetectors are well-known for their high sensitivity and fast response times, they are often discouraged by high fabrication costs, rigid device structures, and poor industrial scalability. Fortunately, recent progress of perovskite materials in various optoelectronics validates the outstanding properties of perovskites, including adjustable bandgaps, strong light absorption, large exciton binding energy, and compatibility with flexible substrates. These properties of perovskite materials lay a solid foundation for low-cost, high-performance, and scalable NIR photodetectors. This review offers a comprehensive roadmap of the recent development of NIR photodetectors, which examines the advancements in inorganic-, polymer-, and perovskite-based devices. The review analyzes several engineering strategies in tailoring device performance metrics and fabrication methods while addressing methods tackling challenges in maintaining stability and scalability and mitigating environmental impact. Additionally, this work specifically highlights recent innovations in perovskite photoactive layers such as multiple quantum wells (MQWs) and perovskite heteros

关键词：

来源：评论

学校读者我要写书评

暂无评论

Measurement of Water Diffusion Coefficient in Cross-Linked Gelatins Using the Terahertz Time-Domain Spectroscopy Technique

Measurement of Water Diffusion Coefficient in Cross-Linked G...

引用

Conference on Lasers and Electro-Optics (CLEO)

作者： D. Walden D. Chakraborty J. Cheng A. Straksys A. Stirke W. CMA Melo A. Jukna I. Komissarov Roman Sobolewski Department of Physics and Astronomy University of Rochester Rochester New York USA Laboratory for Laser Energetics University of Rochester Rochester New York USA Materials Science Graduate Program University of Rochester Rochester New York USA State Research Institute Center for Physical Sciences & Technology Vilnius Lithuania Department of Physics Vilnius Gediminas Technical University Vilnius Lithuania Department of Electrical and Computer Engineering University of Rochester Rochester New York USA

A novel method has been developed to evaluate the water diffusion dynamics in gelatin-based gels, based on transient terahertz time-domain spectroscopy measurements. Such gels are widely used models for human skin.

ISBN: (纸本)9798350369311

关键词： Spectroscopy Measurement by laser beam Lasers and electrooptics Laser modes Skin Time-domain analysis Transient analysis Electro-optical waveguides

来源：评论

学校读者我要写书评

暂无评论

Thermography for the detection of Secondary Raynaud's Phenomenon by means of the Distal-Dorsal Distance

Thermography for the detection of Secondary Raynaud's Phenom...

引用

Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： J.R. Viana D. Campos L. Ulbricht G.Y. Sato W.L. Ripka Universidade Tecnológica Federal do Paraná with the Graduate Program in Biomedical Engineering Curitiba Brazil Federal University of Paraná with the Graduate Program in Physical Education

ISBN: (数字)9781728119908

ISBN: (纸本)9781728119915

Raynaud's phenomenon (RP) is a disease characterized by a transient ischemic process, in an exaggerated vascular response to cold or emotional stress. Thermography is a resource applied to support diagnosis of changes in the circulatory system. The aim of the study was to use the DistalDorsal Thermography Difference (DDD) in thermographic images to assess thermal behavior in individuals with secondary RP. The research was carried out in the period between 2018 and 2019. The sample means of the Distal-consisted of 44 individuals in a control group (Control) and 44 individuals in a pathological group (RP2). The participants, after acclimatization, were submitted to the cold stress protocol. The protocol consisted of immersing hands in a container of water at a temperature of 15°C for 60 seconds. The acquisition of thermographic images was performed at the pre-test moment and at the 1st, 3rd, 5th, 7th, 10th and 15th minute. At each time, the DDD values (of all fingers - minimum, maximum and sum) between the groups were analyzed. For statistical analysis, the independent t test and Cohen's d test were used. Regarding the results, there was a difference in relation to the rate of temperature recovery between the groups. The first group showed a rate of reheating just after the first minute subsequent to the cold stress test, while the RP2 group was unable to recover the temperature over 15 minutes. DDD, regardless of the selected criterion, proved to be a valid index for verifying the temperature gradient in the study with individuals identified with secondary RP.

关键词： Thumb Temperature measurement Diseases Stress Protocols Temperature sensors

来源：评论

学校读者我要写书评

暂无评论

Cyclodextrin-Modified Layered Double Hydroxide Thin-Film Nanocomposite Desalination Membrane for Boron Removal

SSRN

引用

SSRN 2023年

作者： Ee, Liang Ying Zhao, Qipeng Gao, Jie Lim, Chit Kai Xue, Kai Chin, Sze Yuet Li, Sam Fong Yau Chung, Tai-Shung Chen, Shing Bor Department of Chemical and Biomolecular Engineering College of Design and Engineering National University of Singapore 4 Engineering Drive 4 Singapore117585 Singapore Department of Chemistry College of Humanities and Sciences National University of Singapore 3 Science Drive 3 Singapore117543 Singapore Chemical Engineering Program Physical Science and Engineering Division King Abdullah University of Science and Technology Thuwal23955-6900 Saudi Arabia Centre of High Field NMR Spectroscopy and Imaging School of Physical and Mathematical Sciences College of Science Nanyang Technological University 21 Nanyang Link Singapore637371 Singapore NUS Environmental Research Institute National University of Singapore T-Lab Building 5A Engineering Drive 1 Singapore117411 Singapore Graduate Institute of Applied Science and Technology National Taiwan University of Science and Technology Taipei106335 Taiwan

The elimination of small and potentially toxic boron species in water is always a significant challenge for conventional membrane technologies. In this study, facile intercalation and functionalization of β-cyclodextrin (CD) onto layered double hydroxides (LDHs) have resulted in the formation of accessible hydroxyl functional groups and anions that exhibit strong sorption with boron. Through meticulous molecular design and optimization, the modified LDH possessing the maximum boron adsorption capacity of 96.1 mg g-1 was employed to fabricate a polyamide-based thin-film nanocomposite (TFN) membrane with a loading of 0.10 wt.%. This resultant membrane displayed a high salt rejection and water permeance of 99.4 % and 2.68 LMH bar-1 for brackish water, respectively, which can be attributed to the increased interlayer spacing of 1.67 nm and the thinner selective layer. The innovative TFN membrane also achieved a high boron rejection of 82.3 % against brackish water containing 2,000 mg L-1 NaCl and 15 mg L-1 B at pH 8. This pioneering study provides valuable insights into the design of brackish water reverse osmosis (BWRO) membranes, through the synergistic use of macrocyclic molecules and inorganic layered nanomaterials, that could potentially revolutionize water reuse and boron removal applications. © 2023, The Authors. All rights reserved.

关键词： Sodium chloride

来源：评论

学校读者我要写书评

暂无评论

Designing the pressure-dependent shear modulus using tessellated granular metamaterials

arXiv

引用

arXiv 2023年

作者： Zhang, Jerry Wang, Dong Jin, Weiwei Xia, Annie Pashine, Nidhi Kramer-Bottiglio, Rebecca Shattuck, Mark D. O’Hern, Corey S. Department of Mechanical Engineering & Materials Science Yale University New HavenCT06520 United States Benjamin Levich Institute and Physics Department The City College of New York New YorkNY10031 United States Department of Physics Yale University New HavenCT06520 United States Department of Applied Physics Yale University New HavenCT06520 United States Integrated Graduate Program in Physical and Engineering Biology Yale University New HavenCT06520 United States

Jammed packings of granular materials display complex mechanical response. For example, the ensemble-averaged shear modulus 〈G〉 increases as a power-law in pressure p for static packings of soft spherical particles that can rearrange during compression. We seek to design granular materials with shear moduli that can either increase or decrease with pressure without particle rearrangements even in the large-system limit. To do this, we construct tessellated granular metamaterials by joining multiple particle-filled cells together. We focus on cells that contain a small number of bidisperse disks in two dimensions. We first study the mechanical properties of individual disk-filled cells with three types of boundaries: periodic boundary conditions (PBC), fixed-length walls (FXW), and flexible walls (FLW). Hypostatic jammed packings are found for cells with FLW, but not in cells with PBC and FXW, and they are stabilized by quartic modes of the dynamical matrix. The shear modulus of a single cell depends linearly on p. We find that the slope of the shear modulus with pressure, λc c > 0, as well as λc © 2023, CC BY.

关键词： Elastic moduli

来源：评论

学校读者我要写书评

暂无评论

Mechanical Plasticity of Cell Membranes Enhances Epithelial Wound Closure

arXiv

引用

arXiv 2023年

作者： Ton, Andrew T. MacKeith, Arthur K. Shattuck, Mark D. O'Hern, Corey S. Department of Physics Yale University New HavenCT06520 United States Integrated Graduate Program in Physical and Engineering Biology Yale University New HavenCT06520 United States Department of Mechanical Engineering & Materials Science Yale University New HavenCT06520 United States Benjamin Levich Institute and Physics Department The City College of New York New YorkNY10031 United States Department of Applied Physics Yale University New HavenCT06520 United States

During epithelial wound healing, cell morphology near the healed wound and the healing rate vary strongly among different developmental stages even for a single species like Drosophila. We develop deformable particle (DP) model simulations to understand how variations in cell mechanics give rise to distinct wound closure phenotypes in the Drosophila embryonic ectoderm and larval wing disc epithelium. We find that plastic deformation of the cell membrane can generate large changes in cell shape consistent with wound closure in the embryonic ectoderm. Our results show that the embryonic ectoderm is best described by cell membranes with an elasto-plastic response, whereas the larval wing disc is best described by cell membranes with an exclusively elastic response. By varying the mechanical response of cell membranes in DP simulations, we recapitulate the wound closure behavior of both the embryonic ectoderm and the larval wing disc. © 2023, CC BY-NC-ND.

关键词： Cytology

来源：评论

学校读者我要写书评

暂无评论

Cold atmospheric plasma-enabled platelet vesicle incorporated iron oxide nano-propellers for thrombolysis

引用

Materials Today Bio 2023年 23卷 100876页

作者： Jheng, Pei-Ru Chiang, Chia-Che Kang, Jiunn-Horng Fan, Yu-Jui Wu, Kevin C.-W. Chen, Yan-Ting Liang, Jia-Wei Bolouki, Nima Lee, Jyh-Wei Hsieh, Jang-Hsing Chuang, Er-Yuan Graduate Institute of Nanomedicine and Medical Engineering Graduate Institute of Biomedical Materials and Tissue Engineering Institute of Biomedical Optomechatronics International Ph.D. Program in Biomedical Engineering School of Biomedical Engineering College of Biomedical Engineering Professional Master Program in Artificial Intelligence in Medicine College of Medicine Taipei Medical University Taipei11031 Taiwan Department of Physical Medicine and Rehabilitation Taipei Medical University Hospital Taipei Taiwan Institute of Biomedical Engineering & Nanomedicine National Health Research Institute Keyan Road Zhunan Miaoli City350 Taiwan Department of Chemical Engineering National Taiwan University No.1 Sec. 4 Roosevelt Rd Taipei10617 Taiwan Department of Plasma Physics and Technology Faculty of Science Masaryk University Brno Czech Republic Center for Plasma and Thin Film Technologies Ming Chi University of Technology New Taipei City Taiwan Department of Materials Engineering Ming Chi University of Technology New Taipei City Taiwan Cell Physiology and Molecular Image Research Center Taipei Medical University-Wan Fang Hospital Taipei11696 Taiwan

A new approach to treating vascular blockages has been developed to overcome the limitations of current thrombolytic therapies. This approach involves biosafety and multimodal plasma-derived theranostic platelet vesicle incorporating iron oxide constructed nano-propellers platformed technology that possesses fluorescent and magnetic features and manifold thrombus targeting modes. The platform is capable of being guided and visualized remotely to specifically target thrombi, and it can be activated using near-infrared phototherapy along with an actuated magnet for magnetotherapy. In a murine model of thrombus lesion, this proposed multimodal approach showed an approximately 80 % reduction in thrombus residues. Moreover, the new strategy not only improves thrombolysis but also boosts the rate of lysis, making it a promising candidate for time-sensitive thrombolytic therapy. © 2023 The Authors

关键词： Infrared devices

来源：评论

学校读者我要写书评

暂无评论

Assessment of scoring functions for computational models of protein-protein interfaces

arXiv

引用

arXiv 2024年

作者： Sumner, Jacob Meng, Grace Brandt, Naomi Grigas, Alex T. Córdoba, Andrés Shattuck, Mark D. O’Hern, Corey S. Graduate Program in Computational Biology and Bioinformatics Yale University New HavenCT06520 United States Integrated Graduate Program in Physical and Engineering Biology Yale University New HavenCT06520 United States Department of Chemistry Yale University New HavenCT06520 United States Department of Physics Yale University New HavenCT06520 United States Department of Chemistry Duke University DurhamNC27708 United States Department of Physics Duke University DurhamNC27708 United States Benjamin Levich Institute Physics Department City College of New York New YorkNY10031 United States Department of Mechanical Engineering and Materials Science Yale University New HavenCT06520 United States Department of Applied Physics Yale University New HavenCT06520 United States

A goal of computational studies of protein-protein interfaces (PPIs) is to predict the binding site between two monomers that form a heterodimer. The simplest version of this problem is to rigidly re-dock the bound forms of the monomers, which involves generating computational models of the heterodimer and then scoring them to determine the most native-like models. Scoring functions have been assessed previously using rank- and classification-based metrics, however, these methods are sensitive to the number and quality of models in the scoring function training set. We assess the accuracy of seven PPI scoring functions by comparing their scores to a measure of structural similarity to the x-ray crystal structure (i.e. the DockQ score) for a non-redundant set of heterodimers from the Protein Data Bank. For each heterodimer, we generate re-docked models uniformly sampled over DockQ and calculate the Spearman correlation between the PPI scores and DockQ. For some targets, the scores and DockQ are highly correlated;however, for many targets, there are weak correlations. Several physical features can explain the difference between difficult- and easy-to-score targets. For example, strong correlations exist between the score and DockQ for targets with highly intertwined monomers and many interface contacts. We also develop a new score based on only three physical features that matches or exceeds the performance of current PPI scoring functions. These results emphasize that PPI prediction can be improved by focusing on correlations between the PPI score and DockQ and incorporating more discriminating physical features into PPI scoring functions. © 2024, CC BY.

关键词： Monomers

来源：评论

学校读者我要写书评

暂无评论

Determination of Majorana type-phases from the time evolution of lepton numbers

arXiv

引用

arXiv 2022年

作者： Benoit, Nicholas J. Kawamura, Yuta Hamada, Saki Morozumi, Takuya Shimizu, Yusuke Yamamoto, Kei Graduate School of Science Hiroshima University Higashi-Hiroshima739-8526 Japan Mie Yokkaichi City Japan Higashi-Hiroshima Japan Physics Program Graduate School of Advanced Science and Engineering Hiroshima University Higashi-Hiroshima739-8526 Japan Core of Research for the Energetic Universe Hiroshima University Higashi-Hiroshima739-8526 Japan Department of Information Kaishi Professional University Niigata950-0916 Japan Faculty of Science and Engineering Department of Physical Science and Materials Engineering Studies in Mathematical Science and Physics Iwate University Japan

We have investigated an approach to determine the Majorana type-phases using the time evolution of lepton family numbers. The Majorana type-phases are related to the orientation of unitarity triangles for the Pontecorvo-Maki-Nakagawa-Sakata (PMNS) matrix, and the Majorana phases α21 and α31. After taking the second-order time derivative of the lepton family number expectation values, the dependencies on the summation of Majorana type-phases can be determined. Thus allowing for the extraction of the orientation of the unitarity triangles and the Majorana phases. We study how to extract the Majorana type-phases and the lightest neutrino mass for three massive neutrinos, and when a neutrino is massless, i.e., m1,3 = 0. Theoretically, our results indicate lepton number can be used to determine the orientation of the PMNS unitarity triangles and the Majorana phases. To show how the Majorana phases and Majorana-type phases are related to the CP violation for leptogenesis at high energy, we first adopt a parametrization where the diagonal elements of the effective Majorana mass matrix at low energy are given by real positive numbers. In this basis, the phase of the off-diagonal elements related to the CP violating phases in PMNS matrix. We explicitly show the relation between the single Majorana phase and the phase of the effective Majorana mass matrix for two generation case of active neutrinos. Then for type I seesaw model with two gauge singlet neutrinos and two families of lepton doublet, we study the effective Majorana mass matrix generated by the seesaw model. We are able to show how the Majorana phase at low energy is related to two CP violating phases in the seesaw model and the relation between Majorana phase at low energy and CP violating phases related to the lepton number asymmetries of the heavy Majorana neutrinos decays is established. © 2022, CC BY.

关键词： Neutrons

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：