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2006 IEEE/NLM Life science Systems and Applications Workshop, LiSA 2006

作者： Koev, Stephan T. Powers, Michael A. Badilita, Vlad Yi, Hyunmin Bentley, William E. Payne, Gregory F. Rubloff, Gary W. Ghodssi, Reza Department of Electrical and Computer Engineering University of Maryland College Park MD 20742 Department of Materials Science and Engineering University of Maryland College Park MD 20742 Department of Chemical Engineering University of Maryland College Park MD 20742 University of Maryland College Park MD 20742 University of Maryland College Park MD 20742 Bioengineering Graduate Program University of Maryland College Park MD 20742

ISBN: (纸本)1424402786

We present the use of the polysaccharide chitosan for immobilizing biomolecules on microfabricated device surfaces. The main advantages of chitosan are its abundance of primary amine groups and its ability to be electrodeposited. Biomolecules are easily attached to chitosan's amines by standard glutaraldehyde chemistry. The electrodeposition of chitosan allows accurate spatial and temporal control of biomolecule placement. We have demonstrated this biofunctionalization method for two different BioMEMS devices: a biophotonic sensor and a micromechanical biosensor. We have successfully assembled probe DNA on each of them and detected hybridization with target DNA as a demonstration of sensor operation. Here, we briefly present the fabrication procedure and testing results for both of these BioMEMS sensing devices. © 2006 IEEE.

关键词： Microsystems

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Capturing Cellular Communication with Guided Electrode Network on a Silicon Integrated Circuit Chip

Capturing Cellular Communication with Guided Electrode Netwo...

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2006 8th International Conference on Solid-State and Integrated Circuit Technology

作者： Mansun Chan Chi-Kong Yeung Yijin Wang Jin He Sven Ingebrandt Andreas Offenhaeusser Dept.of Electronic and Computer Engineering Hong Kong University of Science & Technology Bioengineering Graduate Program Hong Kong University of Science & Technology Institute of Microelectronic Peking University Juelich Research Center Institute for Thin Films and Interfaces(ISG-2)Leo-Brandt Str.52425 JuelichGermany

ISBN: (纸本)1424401607

This paper describes the development of a Multi-Electrode Array(MEA)with Guided Network for Cell-to-Cell Communication Transduction using a standard integrated circuit(IC) fabrication *** conventional electronic system,bio-system requires a special handling environment that is uncommon in conventional IC *** work presented here demonstrated the interaction between electrically active cells such as neuron and cardiac cells and an IC based *** a carefully designed array,and ionic action of a cell, extracellular signals can be captured and imaged.

关键词： Capturing Cellular Communication with Guided Electrode Network on a Silicon Integrated Circuit Chip

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Real-time organ motion tracking and fast image registration system for MRI-guided surgery

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Systems and computers in Japan 2006年第1期37卷 83-92页

作者： Tokuda, Junichi Hirano, Masaya Tsukamoto, Tetsuji Dohi, Takeyoshi Hata, Nobuhiko Graduate School of Information Science and Technology University of Tokyo Tokyo 113-8656 Japan GE Yokogawa Medical Systems Ltd. Hino 191-8503 Japan International Society for Computer-Aided Surgery Japan Society for Computer-Aided Surgery Japan Society for Magnetic Resonance in Medicine GE Yokogawa Medical Systems Ltd. Imaging Application Tech. Center MR Group R and D Laboratory Technology Center GE Yokogawa Medical Systems Ltd. Society for Magnetic Resonance in Medicine Graduate School of Information Science and Technology Society for Life Support Technology Japan Society for Organ Preservation Biology and Medicine Society for Precision Engineering Society for Medical Image Computing and Computer Assisted Intervention International Union for Physics and Engineering Sciences in Medicine JSMEBE Japan Society for Life Assistance Technology Brigham and Women's Hospital Harvard Medical School MR Therapy Program

The advantage of magnetic resonance imaging (MRI)-guided surgery, in which MR images taken during surgery are used to guide the surgery, has been recognized recently. However, there is a problem, due to long imaging time of MRI, that it is difficult to capture the respiratory organ motion. It is often a constraint that the patient must hold his or her breath, especially in the treatment of the abdominal region. Consequently, this paper proposes a method of eliminating this constraint in MRI-guided surgery by real-time monitoring of the movement of the organ involved in the surgery by means of the signal derived from MRI. Specifically, the navigator echo is extracted in imaging during surgery. The movement of the organ involved in surgery is detected on the basis of the change in the calculated projection profile, and the results are presented to the surgeon. In this study, the procedure is built into a 1.5-T clinical MRI system. The feasibility of the proposed system was examined under clinical conditions by evaluating its accuracy and delay in a phantom experiment, and also in an in vivo experiment on the liver of a volunteer. The results are reported in this paper. © 2005 Wiley Periodicals, Inc.

关键词： Motion estimation

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Identifying interaction sites in "Recalcitrant" proteins: Predicted protein and RNA binding sites in REV proteins of HIV-1 and EIAV agree with experimental data

Identifying interaction sites in "Recalcitrant" proteins: Pr...

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11th Pacific Symposium on Biocomputing 2006, PSB 2006

作者： Terribllini, Michael Lee, Jae-Hyung Yan, Changhui Jernigan, Robert L. Carpenter, Susan Honavar, Vasant Dobbs, Drena Bioinformatics and Computational Biology Graduate Program LH. Baker Center for Bioinformatics and Biological Statistics Iowa State University Ames IA 50010 United States Department of Computer Science Iowa State University Ames IA 50010 United States Department of Biochemistry Biophysics and Molecular Biology Iowa State University Ames IA 50010 United States Department of Genetics Development and Cell Biology Iowa State University Ames IA 50010 United States Artificial Intelligence Research Laboratory Center for Computational Intelligence Learning and Discovery Iowa State University Ames IA 50010 United States Department of Veterinary Microbiology and Pathology Washington State University Pullman WA. 99164 United States

ISBN: (纸本)9812564632

Protein-protein and protein nucleic acid interactions are vitally important for a wide range of biological processes, including regulation or gene expression, protein synthesis, and replication and assembly of many viruses. We have developed machine learning approaches for predicting which amino acids of a protein participate in its interactions with other proteins and/or nucleic acids, using only the proiein sequence as input. In this paper, we describe an application of classifiers trained on datasets of well-characterized protein-protein and protein-RNA complexes for which experimental structures are available. We apply these classifiers to the problem of predicting protein and RNA binding sites in the sequence of a clinically important protein for which the structure is not known: the regulatory protein Rev, essential for the replication of HIV-I and other lentiviruses. We compare our predictions with published biochemical, genetic and partial structural information for HIV-1 and EIAV Rev and with our own published experimental mapping of RNA binding sites in EIAV Rev. The predicted and experimentally determined binding sites are in very good agreement. The ability to predict reliably the residues of a protein that directly contribute to specific binding events - without the requirement for structural information regarding either the protein or complexes in which it participates - can potentially generate new disease intervention strategies.

关键词： Binding sites

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U.S. Government computer Search and Seizure Policies

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EDPACS 2006年第9期26卷 13-20页

作者： Randy Coneby Frederick Gallegos Assistant Director of Audits with the United States Postal Service in Washington D.C. Prior to joining the U.S. Postal Service he was an Audit Manager and IS Auditor with the U.S. Air Force Audit Agency at March AFB California. He is a graduate of the Master of Science in Business Administration Program (Option – IS Auditing) at the California State Polytechnic University at Pomona. An adjunct professor and the MSBA-Information Systems Audit Advisor for the Computer Information Systems Department the College of Business Administration at the California State Polytechnic University at Pomona.

This article reviews the way in which the spread of computing technology has impacted the search and seizure policies of relevant U.S. government agencies. Among the changes that have occurred is a total redesign by the Justice Department of its search and seizure guidelines and policies. the article discusses numerous questions that involve search and seizure procedures as they pertain to the use of computing technology.

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A business-oriented perspective for QoS management

A business-oriented perspective for QoS management

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2004 IEEE Workshop on IP Operations and Management Proceedings, IPOM 2004: Self-Measurement and Self-Management of IP Networks and Services

作者： Penna, Manoel Camillo Kaestner, Celso Wandresen, Rafael Romualdo Post Graduate Program in Computer Science Pontifical Catholic University of Parana Curitiba Brazil

ISBN: (纸本)0780388364

Research efforts in Quality of Service (QoS) management have usually addressed the problem under the network infrastructure perspective whereas a business-oriented perspective, named Service Quality Management (SQM), is being considered by industry. This paper point out differences and similarities between two approaches and addresses the main issues arising under SQM perspective. Here, QoS indicators and corresponding service levels are defined to provide a common understanding of service delivery, and a critical issue is to provide an effective way to evaluate them. Two evaluation modes are used: off-line and on-line. Off-line methods compute indicators values at the end of a pre-defined evaluation period, whereas on-line methods do it when a related event occurs. This work proposes an architecture for SQM systems and discusses the mechanisms for both off-line and on-line evaluation modes. ©2004 IEEE.

关键词： Quality of service

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An alternative metric for channel estimation with applications in Bluetooth scheduling

An alternative metric for channel estimation with applicatio...

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IFIP TC6/WG6.8 Conference on Mobile and Wireless Communication Networks, MWCN 2004

作者： Kleinschmidt, João H. Pellenz, Marcelo E. Lima Jr., Luiz A. P. Graduate Program in Computer Science Pontifical Catholic University of Paraná Curitiba - PR Brazil

ISBN: (纸本)038723148X

Once Wireless Local Networks (WLAN) and Bluetooth devices share the same frequency band (ISM) there is a potential risk of interference if they are supposed to operate close to each other. Additionally, the signal fading effects on mobile Bluetooth networks may deeply affect the overall performance. That is why the use of strategies that minimize transmission on channels with great interference or severe fading is so important. This paper proposes and investigates the use of parameter m of the Nakagami distribution, as the channel estimation metric. We observed that parameter m may provide faster estimates on the channel condition than the bit error rate metric. This metric is applied in a new scheduling algorithm for Bluetooth piconets. Simulation results showing the performance of the algorithm for different traffic conditions are eventually presented. © 2005 by International Federation for Information Processing.

关键词： Scheduling algorithms

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Transforming K-12 education via the collaborative large-scale engineering analysis network for environmental research (CLEANER) project

Transforming K-12 education via the collaborative large-scal...

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113th Annual ASEE Conference and Exposition, 2006

作者： Eschenbach, Elizabeth Johnson, James H. Brus, Chris Carlson, Patricia Giammar, Dan Grauer, Bette Hotaling, Liesl Oguntimein, Gbekeloluwa Safferman, Steven Wentling, Tim Humboldt State University United States Department of Environmental Resources Engineering Humboldt State University United States Howard University United States Department of Environmental Engineering College of Engineering Architecture and Computer Sciences Howard University United States Board of Scientific Counselors Executive Committee U.S. Environmental Protection Agency Office of Research and Development United States EPA's Science Advisory Board Department of Energy-sponsored HBCU/MI Environmental Technology Consortium Board Environmental Studies and Toxicology and the Engineering Council of the American Society for Engineering Education United States University of Iowa United States Program University of Iowa United States Rose-Hulman Institute of Technology United States Department of Rhetoric Rose-Hulman Institute ot Technology U.S. Air Forcer United States Army's Aberdeen Proving Ground NASA's Classroom of the Future Wheeling WV United States Washington University United States Department of Civil Engineering Washington University St. Louis United States Environmental Engineering Science Program Center for Materials Innovation United States McPherson High School United States McPherson High School McPherson KS United States Stevens Institute of Technology United States Stevens Institute of Technology United States Morgan State University United States Michigan State University United States Biosystems and Agricultural Engineering Department Michigan State University United States University of Dayton United States U.S. EPA Office of Research and Development United States National Center for Supercomputing Applications United States Department of Information Science Graduate School of Library and Information Science National Center for Supercomputing Applications University of Illinois United States

The Collaborative Large-scale Engineering Analysis Network for Environmental Research (CLEANER) Project Office has been established with funding from the National science Foundation (NSF) to the University of Illinois Urbana-Champaign (UIUC) and a coalition of 11 other institutions. The project office is coordinating the creation of a strategic plan consisting of research, cyberinfrastructure, and education plans that set forth a roadmap for the collaborative engineering analysis network for the study of environmental problems. This report will be completed by July 2007 and requires input from K-12 educators, administrators and other stakeholders in K-12 education. This paper describes the CLEANER project, provides an example of the CLEANER Education Committee's vision for the K-12 area and lists contacts for further information. The intention of this paper is to elicit input from the K-12 engineering education community, including K-12 educators, on how the CLEANER Education Plan could better meet the future needs of K-12 students and educators © American Society for Engineering Education, 2006.

关键词： Engineering education

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Power efficient error control for bluetooth-based sensor networks

Power efficient error control for bluetooth-based sensor net...

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IEEE Conference on Local computer Networks - 30th Anniversary, LCN 2005

作者： Kleinschmidt, João H. Borelli, Walter C. Pellenz, Marcelo E. School of Electrical and Computer Engineering State University of Campinas - UNICAMP Graduate Program in Computer Science Pontifical Catholic University of Paraná - PUCPR

ISBN: (纸本)0769524214

This paper- studies different error control schemes in wireless sensor networks with Bluetooth technology. The tradeoff between reliability and energy consumption of Bluetooth packets are analyzed, using different error control techniques, such as retransmission and channel coding The AUX1 packet is utilized for custom coding and also are proposed adaptive techniques based on the number of hops of the network. The wireless channel is modeled with Rayleigh fading. The results obtained may be used as references to determine the packet type in a sensor application. © 2005 IEEE.

关键词： Wireless telecommunication systems

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A kernel method for MicroRNA target prediction using sensible data and position-based features

A kernel method for MicroRNA target prediction using sensibl...

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2005 IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology, CIBCB '05

作者： Kim, Sung-Kyu Nam, Jin-Wu Lee, Wha-Jin Zhang, Byoung-Tak Graduate Program in Bioinformatics School of Computer Science and Engineering Seoul National University Seoul 151-744 Korea Republic of

ISBN: (纸本)0780393872

MicroRNAs (miRNAs) are small endogenous RNAs of ∼22nt that act as direct post-transcriptional regulators in animals and plants. MicroRNAs generally perform a function by binding to the complementary site on the 3' untranslated region of Its target gene and especially the Smers on the 5' part of miRNA seems important as a seed. Computational methods for miRNA target prediction have been focusing on this seed region, but recent researches revealed that the specificity of the seed region may be sharply decreased even by a point mutation. In this paper, we present a kernel method for miRNA target prediction in animals, which improves the prediction performance with biologically sensible data and position-based features reflecting the way of miRNA:mRNA pairing mechanism. In building a training dataset, we choose experimentally verified data only to improve the quality of dataset by excluding randomly synthesized one and consequently to make the result of learning valid. We use sensitivity, specificity, and area under ROC curve as performance measures of our algorithm and compare the results of various dataset configurations. The overall results were 92.1% in sensitivity, 83.3% in specificity, and 0.931 in area under ROC curve. With position-based features, an increase of 3.3% in sensitivity and 1.6% in specificity were observed. In the feature selection experiment to investigate the role of individual position-based features, the result suggests that pairing at positions 4, 5, 6 of the seed part is of greater importance than the other positions together with the general stability of the seed part. © 2005 IEEE.

关键词： RNA

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