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191 Dose prescription variability in Oropharynx Cancer Radiotherapy

Radiotherapy and Oncology 2024年 192卷 S225-S228页

作者： Christian R Hansen Tony Tadic Andrea McNiven Jens Petersen Sharma Manju Gareth Price Mohamed A Naser Pernille Lassen Jens Overgaard Lachlan McDowell Clifton David Fuller David Thomsen Sue S Yom J⊘rgen Johansen Jeppe Friborg Andrew Hope Laboratory of Radiation Physics Odense University Hospital Odense Denmark. Institute of Clinical Research University of Southern Denmark Odense Denmark. Danish Center of Particle Therapy Aarhus University Hospital Aarhus Denmark. Department of Medical Physics Princess Margaret Cancer Centre Toronto Canada. Department of Oncology Copenhagen University Hospital Rigshospitalet Copenhagen Denmark. Department of Computer Science University of Copenhagen Copenhagen Denmark. Department of Radiation Oncology University of California San Francisco San Francisco USA. Division of Cancer Sciences University of Manchester The Christie NHS Foundation Trust Manchester United Kingdom. Department of Radiation Oncology Baylor College of Medicine Houston USA. Department of Radiation Oncology The University of Texas MD Anderson Cancer Center Houston USA. Medical Physics Program The University of Texas Graduate School of Biomedical Sciences Houston USA. Department of Experimental Clinical Oncology Aarhus University Hospital Aarhus Denmark. Department of Oncology Aarhus University Hospital Aarhus Denmark. Department of Radiation Oncology Princess Alexandra Hospital Brisbane Australia. Department of Oncology Odense University Hospital Odense Denmark. Department of Otolaryngology-Head Neck Surgery Princess Margaret Cancer Centre Toronto Canada

Purpose/Objective Radiotherapy treatment planning hinges on a critical factor: the prescribed dose. Surprisingly, no consistent, standardised global approach to interpreting this prescription exists. This study aimed to examine and illustrate the variations in prescribed doses for the same treatment across North European and North American centres. Material/Methods The study analysed consecutively treated oropharynx cancer patients from six globally recognised radiotherapy departments. The criteria for inclusion encompassed curative IMRT or VMAT radiotherapy administered in 2017 or later. These centres were divided into three North American and three North European centres. Dose-volume histogram (DVH) data were extracted from the local treatment planning system for the Gross Tumour Volume (GTV), the high-dose Clinical Target Volume (CTV), and Planning Target Volume (PTV) for each patient. The DVH was sampled in 1 cGy dose bins across the 0 to 100 Gy range. All DVHs were scaled to a standard prescription of 70 Gy delivered in 35 fractions to facilitate straightforward comparisons across centres. No biological corrections were applied. For the three target volumes (GTV, CTV, PTV), we extracted and compared metrics such as D95% (Dose to 95% of the volume), D98%, D99%, V95% (Volume receiving 95% of the prescription dose), V105%, and V107%. We visually compared these metrics and conducted statistical testing using the Mann-Whitney U-test. Results Our study encompassed 1,375 patients treated across six centres, revealing a spectrum of 38 different dose prescriptions, ranging from 55 Gy in 20 to 70 Gy in 35 fractions. When normalised to 70 Gy, the median mean CTV dose exhibited a 4% difference, ranging from 70.12 Gy to 72.93 Gy across centres. Notably, the three European centres showed a high consistency, deviating by only 0.4%, while the three North American centres showed a slight variation within 2%. Figure 1 presents the mean CTV dose and the D98% boxplots. The interqu

关键词： HPV or EBV related cancers Dose prescription Treatment planning Trials

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Author Correction: Profiling immunoglobulin repertoires across multiple human tissues using RNA sequencing

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Nature communications 2020年第1期11卷 4499页

作者： Igor Mandric Jeremy Rotman Harry Taegyun Yang Nicolas Strauli Dennis J Montoya William Van Der Wey Jiem R Ronas Benjamin Statz Douglas Yao Velislava Petrova Alex Zelikovsky Roberto Spreafico Sagiv Shifman Noah Zaitlen Maura Rossetti K Mark Ansel Eleazar Eskin Serghei Mangul Department of Computer Science University of California Los Angeles 404 Westwood Plaza Los Angeles CA 90095 USA. Department of Clinical Pharmacy School of Pharmacy University of Southern California 1540 Alcazar Street Los Angeles CA 90033 USA. Bioinformatics Interdepartmental Ph.D. Program University of California Los Angeles 611 Charles E. Young Drive East Los Angeles CA 90095-1570 USA. Biomedical Sciences Graduate Program University of California San Francisco 1675 Owens Street Suite 310 San Francisco CA 94143-0523 USA. Department of Molecular Cell and Developmental Biology University of California Los Angeles 610 Charles E. Young Drive South Los Angeles CA 90095 USA. Department of Microbiology Immunology and Molecular Genetics University of California Los Angeles 609 Charles E. Young Drive East Los Angeles CA 90095 USA. Program in Bioinformatics and Integrative Genomics Harvard Medical School 10 Shattuck Street Suite 514 Boston MA 02115 USA. Wellcome Trust Sanger Institute Wellcome Genome Campus Hinxton Cambridge CB10 1SA UK. Department of Computer Science Georgia State University 33 Gilmer Street SE Atlanta GA 30303 USA. The Laboratory of Bioinformatics I.M. Sechenov First Moscow State Medical University Moscow 119991 Russia. Institute for Quantitative and Computational Biosciences University of California Los Angeles 611 Charles E. Young Drive East Los Angeles CA 90095 USA. Department of Genetics The Institute of Life Sciences The Hebrew University of Jerusalem Jerusalem 9190401 Israel. Department of Medicine University of California San Francisco 533 Parnassus Avenue San Francisco CA 94143 USA. Immunogenetics Center Department of Pathology and Laboratory Medicine David Geffen School of Medicine University of California Los Angeles 1000 Veteran Avenue Los Angeles CA 90095-1652 USA. Sandler Asthma Basic Research Center Department of Microbiology and Immunology University of California San Francisco 513 Parnass

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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BHEL Smart Wall Blowing System: New Product Development in Manufacturing Industry

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Vikalpa 2021年第4期45卷 240 - 249页

作者： Abhishek Kumar R. Dhanuskodi R. Kaliappan K. Nandakumar Abhishek Kumar teaches design philosophies at Anant National University Ahmedabad. He earned his Ph.D in Management from Pondicherry University. He is an Economics graduate from Calcutta University and MBA from BIM Trichy. He has published more than 20 articles in reputed international journals has authored two books written articles and columns for newspapers and is quoted on issues related to leadership and marketing by various media platforms. His research work comprises construction of brand personality scale for media aesthetics and phenomenological design. His recent publications are on philosophy of a photograph hermeneutic reality of product and on philosophy of intimate spaces. R. Dhanuskodi has nearly 40 years of R&D experience at BHEL India in technical areas applicable for thermal power plants. He is a life member of The Institution of Engineers (India) and The Combustion Institute. He has won two BHEL’s Excel awards under the best author category for technical papers. He has visited France Netherlands and Germany under Indo-Europe Clean Coal Development Program. He has guided 42 UG PG and PhD project works. He holds 11 patents 40 copyrights and 2 design registrations. He has presented papers in 20 conferences and published in 10 national and international journals. R. Kaliappan completed his bachelors in electrical and electronics engineering and Masters in Computer Science. He has 36 years of research experience in different fields of power generation and power plant subsystems such as heat transfer studies on boiler circulation efficiency improvements of boiler subsystems product improvements/ enhancements and setting up test facilities for research studies. He has published a number of technical papers on MHD power generation and heat transfer studies in various national and international journals. He has more than 25 patents and copyrights on products development related to power boilers. He has won BHEL’S gold medal for product development for Smart Wall Blowing system. K. Nandakumar

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Abstracts from the 2011 Joint Annual Meeting of the Society for Northwestern Vertebrate Biology and Washington Chapter of the Wildlife Society, Held at the Wesley Inn, Gig Harbor, Washington, March 23–25, 2011

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Northwestern Naturalist 2011年第2期92卷 136-166页

作者： Michael J. Adams Christopher A. Pearl Jessica Y. Adkins Daniel D. Roby Ladd Bayliss Peter J. Loschl Donald E. Lyons Yasuko Suzuki Hannah E. Anderson Sarah T. Hamman Keith B. Aubry Catherine M. Raley John J. Rohrer Eric C. Lofroth Scott H. Fitkin Michael L. Best Hartwell H. Welsh Jamie B. Bettaso Don T. Ashton Hartwell H. Welsh Scott McBain Lindsay M. Biga Andrew R. Blaustein Susan F. Brady R. Steven Wagner Daniel J. Selski James E. Johnson R. Bruce Bury Wynn W. Cudmore Hartwell H. Welsh Nathan D. Chelgren Tara Chestnut Chaucney W. Anderson Julie Kirshtein Megan T. Cook Tiffany S. Garcia Stephen Corn Erin Muths Amanda Kissel Rick Scherer Eric Delvin Jonathan D. Bakker Peter W. Dunwiddie Diana L. Dishman Deborah A. Duffield Harriet R. Huber Dyanna M. Lambourn Karen M. Dvornich Greg Falxa Gary M. Fellers Patrick M. Kleeman David Miller Brandon Fessler Jason T. Irwin Daniel D. Beck R. Steven Wagner Marc P. Hayes John A. Frew Christian E. Grue Chris R. Friesen Robert T. Mason Stevan J. Arnold Suzanne Estes Tiffany S. Garcia Katie M. Dugger Josh Johnson Mike Rochelle A. J. Kroll Stephanie S. Gervasi Caren S. Goldberg Dan Davis Erica Bree Rosenblum Bill Bosworth Lisette P. Waits Purnima Govindarajulu Gregory A. Green Steve Negri Jennifer R. Griffiths Daniel E. Schindler Christian E. Grue Karen M. Dvornich Adam G. Hansen David A. Beauchamp Casey M. Baldwin Marc P. Hayes Gretchen Padgett-Flohr Blake R. Hossack Winsor H. Lowe Paul Stephen Corn Aaron N. Johnston Kris Kendell Dave Prescott Scott Stevens Peter M. Kiffney Carol Volk Kerensa A. King Christian E. Grue James M. Grassley Andrew J. Kroll Matt Hane Josh Johnston Mike Rochelle Stuart Farber Niels Leuthold Michael J. Adams John P. Hayes Bo Li Michael T. Brett Kent B. Livezey Ilon E. Logan Teresa J. Lorenz Kimberly A. Sullivan Amanda V. Bakian Deanna Lynch Nancy Thomas Krysten Schuler Steven Jeffries Joshua Malt Kelly R. McAllister Joanne P. Schuett-Hames Aimee P. McIntyre Jay E. Jones Eric M. Lund Frithiof T. Waterstrat Jack N. Giovanini Stephen D. Duke Marc P. Hayes US Forest Service Pacific Northwest Research Station Olympia WA 98512 kaubry@fs.fed.us US Forest Service Okanogan-Wenatchee National Forest Methow Valley Ranger District Winthrop WA 98862 British Columbia Ministry of Environment Victoria BC V8W9M1 Washington Department of Fish and Wildlife Winthrop WA 98862 Humboldt State University 1 Harpst St. Arcata CA 95521 addsmike14@*** US Forest Service Pacific Southwest Research Station 1700 Bayside Dr. Arcata CA 95521 hwelsh@fs.fed.us US Fish and Wildlife Service Arcata Field Office 1655 Heindon Road Arcata CA 95521 jamie_bettaso@fws.gov Redwood Sciences Laboratory US Forest Service1700 Bayview Drive Arcata CA 99521 dashton@fs.fed.us hwelsh@fs.fed.us McBain &amp Trush 980 7th Street Arcata CA 95521 scott@*** Oregon State University Environmental Sciences Graduate Program Corvallis OR 97331 lindsay.biga@science.oregonstate.edu Oregon State University Department of Zoology Corvallis OR 97331 US Geological Survey Forest and Rangeland Ecosystem Science Center 3200 SW Jefferson Way Corvallis OR 97331 buryb@usgs.gov Life Science Department Chemeketa Community College Salem OR 97309 wynn.cudmore@chemeketa.edu US Forest Service Redwood Sciences Laboratory 1700 Bayview Drive Arcata CA 95521 hwelsh@fs.fed.us USGS Oregon Water Science Center 2130 SW 5th Avenue Portland OR 97207 chestnut@usgs.gov USGS Headquarters 12201 Sunrise Valley Drive Reston VA 20192 US Geological Survey Northern Rocky Mountain Science Center Aldo Leopold Wilderness Research Institute 790 E. Beckwith Avenue Missoula MT 59801 scorn@usgs.gov US Geological Survey Fort Collins Science Center 2150 Centre Avenue Building C Fort Collins CO 80526 Department of Biological Sciences Simon Fraser University Burnaby BC V5A 1S6 Colorado State University Department of Fishery and Wildlife Biology Fort Collins CO 80523 The Nature Conservancy 120 Union Ave SE Olympia WA 98501 edelvin@tnc.org School of Forest Resources University of Washington Seattle WA

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Author Correction: RADICL-seq identifies general and cell type-specific principles of genome-wide RNA-chromatin interactions

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Nature communications 2021年第1期12卷 3128页

作者： Alessandro Bonetti Federico Agostini Ana Maria Suzuki Kosuke Hashimoto Giovanni Pascarella Juliette Gimenez Leonie Roos Alex J Nash Marco Ghilotti Christopher J F Cameron Matthew Valentine Yulia A Medvedeva Shuhei Noguchi Eneritz Agirre Kaori Kashi Joachim Luginbühl Riccardo Cazzoli Saumya Agrawal Nicholas M Luscombe Mathieu Blanchette Takeya Kasukawa Michiel de Hoon Erik Arner Boris Lenhard Charles Plessy Gonçalo Castelo-Branco Valerio Orlando Piero Carninci RIKEN Center for Integrative Medical Sciences Yokohama Kanagawa 230-0045 Japan. alessandro.bonetti@riken.jp. Laboratory of Molecular Neurobiology Department Medical Biochemistry and Biophysics Karolinska Institutet Stockholm Sweden. alessandro.bonetti@riken.jp. The Francis Crick Institute 1 Midland Road London NW1 1AT UK. RIKEN Center for Integrative Medical Sciences Yokohama Kanagawa 230-0045 Japan. Department of Medicine (H7) Karolinska Institutet Stockholm 141 86 Sweden. Epigenetics and Genome Reprogramming Laboratory IRCCS Fondazione Santa Lucia Rome Italy. Faculty of Medicine Imperial College London Institute of Clinical Sciences London W12 0NN UK. MRC London Institute of Medical Sciences London W12 0NN UK. School of Computer Science McGill University Montréal QC Canada. Department of Biochemistry and Goodman Cancer Research Centre McGill University Montréal QC Canada. Institute of Bioengineering Research Centre of Biotechnology Russian Academy of Science 117312 Moscow Russia. Department of Computational Biology Vavilov Institute of General Genetics Russian Academy of Science 119991 Moscow Russia. Department of Biological and Medical Physics Moscow Institute of Physics and Technology 141701 Dolgoprudny Moscow Region Russia. Laboratory of Molecular Neurobiology Department Medical Biochemistry and Biophysics Karolinska Institutet Stockholm Sweden. Department of Experimental Oncology IEO European Institute of Oncology IRCCS Milan Italy. UCL Genetics Institute University College London London WC1E 6BT UK. Okinawa Institute of Science and Technology Graduate University 1919-1 Tancha Onna-son Kunigami-gun Okinawa 904-0495 Japan. Sars International Centre for Marine Molecular Biology University of Bergen 5008 Bergen Norway. Epigenetics and Genome Reprogramming Laboratory IRCCS Fondazione Santa Lucia Rome Italy. valerio.orlando@kaust.edu.sa. KAUST Environmental Epigenetics Program King Abdullah University of Science and Technology (KAUS

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Overview of KAGRA : Data transfer and management

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Progress of Theoretical and Experimental Physics 2023年第10期2023卷

作者： Akutsu, T Ando, M Arai, K Arai, Y Araki, S Araya, A Aritomi, N Asada, H Aso, Y Bae, S Bae, Y Baiotti, L Bajpai, R Barton, M A Cannon, K Cao, Z Capocasa, E Chan, M Chen, C Chen, K Chen, Y Chiang, C-Y Chu, H Chu, Y-K Eguchi, S Enomoto, Y Flaminio, R Fujii, Y Fujikawa, Y Fukunaga, M Fukushima, M Gao, D Ge, G Ha, S Hagiwara, A Haino, S Han, W-B Hasegawa, K Hattori, K Hayakawa, H Hayama, K Himemoto, Y Hiranuma, Y Hirata, N Hirose, E Hong, Z Hsieh, B Huang, G-Z Huang, H-Y Huang, P Huang, Y-C Huang, Y Hui, D C Y Ide, S Ikenoue, B Imam, S Inayoshi, K Inoue, Y Ioka, K Ito, K Itoh, Y Izumi, K Jeon, C Jin, H-B Jung, K Jung, P Kaihotsu, K Kajita, T Kakizaki, M Kamiizumi, M Kanda, N Kang, G Kawaguchi, K Kawai, N Kawasaki, T Kim, C Kim, J Kim, J C Kim, W S Kim, Y-M Kimura, N Kita, N Kitazawa, H Kobayashi, Y Kojima, Y Kokeyama, K Komori, K Kong, A K H Kotake, K Kozakai, C Kozu, R Kumar, R Kume, J Kuo, C Kuo, H-S Kuromiya, Y Kuroyanagi, S Kusayanagi, K Kwak, K Lee, H K Lee, H W Lee, R Leonardi, M Li, K L Lin, L C-C Lin, C-Y Lin, F-K Lin, F-L Lin, H L Liu, G C Luo, L-W Majorana, E Marchio, M Michimura, Y Mio, N Miyakawa, O Miyamoto, A Miyazaki, Y Miyo, K Miyoki, S Mori, Y Morisaki, S Moriwaki, Y Nagano, K Nagano, S Nakamura, K Nakano, H Nakano, M Nakashima, R Nakayama, Y Narikawa, T Naticchioni, L Negishi, R Quynh, L Nguyen Ni, W-T Nishizawa, A Nozaki, S Obuchi, Y Ogaki, W Oh, J J Oh, K Oh, S H Ohashi, M Ohashi, T Ohishi, N Ohkawa, M Ohta, H Okutani, Y Okutomi, K Oohara, K Ooi, C Oshino, S Otabe, S Pan, K Pang, H Parisi, A Park, J Arellano, F E Peña Pinto, I Sago, N Saito, S Saito, Y Sakai, K Sakai, Y Sakuno, Y Sasaki, Y Sato, S Sato, T Sawada, T Sekiguchi, T Sekiguchi, Y Shao, L Shibagaki, S Shimizu, R Shimoda, T Shimode, K Shinkai, H Shishido, T Shoda, A Somiya, K Son, E J Sotani, H Sugimoto, R Suresh, J Suzuki, T Tagoshi, H Takahashi, H Takahashi, R Takamori, A Takano, S Takeda, H Takeda, M Tanaka, H Tanaka, K Tanaka, T Tanioka, S Martin, E N Tapia San Telada, S Tomaru, T Tomigami, Y Tomura, T Travasso, F Trozzo, L Tsang, T Ts Gravitational Wave Science Project National Astronomical Observatory of Japan (NAOJ) 2-21-1 Osawa Mitaka City Tokyo 181-8588 Japan Advanced Technology Center National Astronomical Observatory of Japan (NAOJ) 2-21-1 Osawa Mitaka City Tokyo 181-8588 Japan Department of Physics The University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo 113-0033 Japan Research Center for the Early Universe (RESCEU) The University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo 113-0033 Japan Institute for Cosmic Ray Research (ICRR) KAGRA Observatory The University of Tokyo 5-1-5 Kashiwa-no-Ha Kashiwa City Chiba 277-8582 Japan Accelerator Laboratory High Energy Accelerator Research Organization (KEK) 1-1 Oho Tsukuba City Ibaraki 305-0801 Japan Earthquake Research Institute The University of Tokyo 1-1-1 Yayoi Bunkyo-ku Tokyo 113-0032 Japan Department of Mathematics and Physics Hirosaki University 3 Bunkyo-cho Hirosaki City Aomori 036-8561 Japan Kamioka Branch National Astronomical Observatory of Japan (NAOJ) 238 Higashi-Mozumi Kamioka-cho Hida City Gifu 506-1205 Japan The Graduate University for Advanced Studies (SOKENDAI) 2-21-1 Osawa Mitaka City Tokyo 181-8588 Japan Korea Institute of Science and Technology Information (KISTI) 245 Daehak-ro Yuseong-gu Daejeon 34141 Korea National Institute for Mathematical Sciences 70 Yuseong-daero 1689 Beon-gil Yuseong-gu Daejeon 34047 Korea International College Osaka University 1-1 Machikaneyama-cho Toyonaka City Osaka 560-0043 Japan School of High Energy Accelerator Science The Graduate University for Advanced Studies (SOKENDAI) 1-1 Oho Tsukuba City Ibaraki 305-0801 Japan Department of Astronomy Beijing Normal University No. 19 Xinjiekou Street Beijing 100875 China Department of Applied Physics Fukuoka University 8-19-1 Nanakuma Jonan Fukuoka City Fukuoka 814-0180 Japan Department of Physics Tamkang University No. 151 Yingzhuan Rd. Danshui Dist. New Taipei City 25137 Taiwan Department of Physics and Institute of Astronomy Nation

KAGRA is a newly built gravitational wave observatory, a laser interferometer with a 3 km arm length, located in Kamioka, Gifu prefecture, Japan. In this article, we describe the KAGRA data management system, i.e., recording of data, transfer from the KAGRA experiment site to computing resources, as well as data distribution to tier sites, including international sites in Taiwan and Korea. The amount of KAGRA data exceeded 1.0 PiB and increased by about 1.5 TB per day during operation in 2020. Our system has succeeded in data management, and has achieved performance that can withstand observations after 2023, that is, a transfer rate of 20 MB s-1or more and file storage of sufficient capacity for petabyte class. We also discuss the sharing of data between the global gravitational-wave detector network with other experiments, namely LIGO and Virgo. The latency, which consists of calculation of calibrated strain data and transfer time within the global network, is very important from the view of multi-messenger astronomy using gravitational waves. Real-time calbrated data delivered from the KAGRA detector site and other detectors to our computing system arrive with about 4–15 seconds of latency. These latencies are sufficiently short compared to the time taken for gravitational wave event search computations. We also established a high-latency exchange of offline calibrated data that was aggregated with a better accuracy compared with real-time data.

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Author Correction: Proteogenomic landscape of human pancreatic ductal adenocarcinoma in an Asian population reveals tumor cell-enriched and immune-rich subtypes

Nature cancer

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Nature cancer 2023年 2023 May 19页

作者： Do Young Hyeon Dowoon Nam Youngmin Han Duk Ki Kim Gibeom Kim Daeun Kim Jingi Bae Seunghoon Back Dong-Gi Mun Inamul Hasan Madar Hangyeore Lee Su-Jin Kim Hokeun Kim Sangyeop Hyun Chang Rok Kim Seon Ah Choi Yong Ryoul Kim Juhee Jeong Suwan Jeon Yeon Woong Choo Kyung Bun Lee Wooil Kwon Seunghyuk Choi Taewan Goo Taesung Park Young-Ah Suh Hongbeom Kim Ja-Lok Ku Min-Sik Kim Eunok Paek Daechan Park Keehoon Jung Sung Hee Baek Jin-Young Jang Daehee Hwang Sang-Won Lee School of Biological Sciences Seoul National University Seoul Republic of Korea. Department of Chemistry and Center for Proteogenome Research Korea University Seoul Republic of Korea. Department of Surgery and Cancer Research Institute Seoul National University College of Medicine Seoul Republic of Korea. Department of Anatomy and Cell Biology and Department of Biomedical Sciences Seoul National University College of Medicine Seoul Republic of Korea. Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Seoul Republic of Korea. Creative Research Initiatives Center for Epigenetic Code and Diseases Seoul National University Seoul Republic of Korea. Department of Biological Sciences College of Natural Sciences and Department of Molecular Science and Technology Ajou University Suwon Republic of Korea. Department of Pathology Seoul National University College of Medicine Seoul Korea. Department of Computer Science Hanyang University Seoul Republic of Korea. Interdisciplinary Program in Bioinformatics Seoul National University Seoul Republic of Korea. Department of Statistics Seoul National University Seoul Republic of Korea. Korean Cell Line Bank Laboratory of Cell Biology Cancer Research Institute Seoul National University College of Medicine Seoul Korea. Department of New Biology Daegu Gyeongbuk Institute of Science and Technology Daegu Republic of Korea. Department of Biological Sciences College of Natural Sciences and Department of Molecular Science and Technology Ajou University Suwon Republic of Korea. dpark@ajou.ac.kr. Department of Anatomy and Cell Biology and Department of Biomedical Sciences Seoul National University College of Medicine Seoul Republic of Korea. keehoon.jung@snu.ac.kr. Institute of Allergy and Clinical Immunology Seoul National University Medical Research Center Seoul Republic of Korea. keehoon.jung@snu.ac.kr. School of Biological Sciences Seoul National University Seoul Republic of

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THE UNITED STATES NAVY'S “DESIGN WORK STUDY” APPROACH TO THE DEVELOPMENT OF SHIPBOARD CONTROL SYSTEMS

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Naval Engineers Journal 1976年第6期88卷 62-74页

作者： PLATO, ARTIS I. GAMBREL, WILLIAM DAVID Artis I. Plato:is Head of the Design Work Study/ Shipboard Manning/Human Factors Engineering Section Systems Engineering and Analysis Branch Naval Ship Engineering Center (NAVSEC). He graduated from the City College of New York in 1956 receiving his Bachelor of Mechanical Engineering degree. Following this he started work at the New York Naval Shipyard in the Internal Combustion Engine and Cargo Elevator Section. During 1957 and 1958 he was called up for active duty with the U.S. Army Corps of Engineers and served in Europe with a Construction Engineer Battalion. After release from active duty he returned to the shipyard where he remained until 1961 when he transferred to the Naval Supply Research and Development Facility Bayonne New Jersey. Initially he was in charge of an Engineering Support Test Group and the drafting services for the whole Facility. Later he became a Project Engineer in the Food Services Facilities Branch with duties that included planning and designing new afloat and ashore messing facilities for the Navy. In 1966 he transferred to NAVSEC as a Project Engineer in the Design Work Study Section and in this capacity worked on selected projects and manning problems for new construction and also developed a computer program (Manpower Determination Model) that makes accurate crew predictions for feasibility studies. In 1969 he became Head of the Section. He has been active in the U.S. Army Reserve since his release from active duty and his duties have included command of an Engineer Company various Staff positions and his present assignment as Operations Officer for a Civil Affairs Group. He has completed the U. S. A rmy Corps of Engineers Career Course and the Civil Affairs Career Course and is presently enrolled in the U.S. Army Command and General Staff College non-resident course. Additionally he completed graduate studies at American University Washington D.C in 1972 receiving his MSTM degree in Technology of Management and is a member of ASE ASME CAA U. S. Naval Instit

The purpose of this paper is to discuss a system analysis technique called “Design Work Study”, that is used by the U.S. Navy for the development of improved ship control systems. The Design Work Study approach is one which brings about the most efficient and cost effective man‐machine combination for the ship control functions. Adherence to this process insures that the advantages of automation are balanced against incurred operational and maintenance expense. At present, U.S. Navy doctrine requires that certain ship operating stations, such as steering and propulsion control, be manned at specified ship conditions of readiness. Therefore, if personnel are needed to fulfill these combat environment obligations, excessive automation may only result in unnecessary additional acquisition costs and increased personnel skill requirements. The Design Work Study process can be applied to establish the required fine balance between the degree of built‐in automation and the shipboard manpower levels. In order to explain the techniques that are used for this process, the Authors will present a brief summary of the Design Work Study approach for optimizing shipboard control systems, including an explanation of the formal procedural tools that are applicable. In addition, a practical case study of ship control system design for one of the latest classes of Navy destroyers will be presented. This example will illustrate the resultant savings and benefits that can be realized by a judicious application of this technique. © 1976 American Society of Naval Engineers

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Author Correction: Genomic footprints of activated telomere maintenance mechanisms in cancer (Dec, 10.1038/s41467-019-13824-9, 2022)

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NATURE COMMUNICATIONS 2022年第1期13卷 1-1页

作者： Sieverling, Lina Hong, Chen Koser, Sandra D. Ginsbach, Philip Kleinheinz, Kortine Hutter, Barbara Braun, Delia M. Cortes-Ciriano, Isidro Xi, Ruibin Kabbe, Rolf Park, Peter J. Eils, Roland Schlesner, Matthias Brors, Benedikt Rippe, Karsten Jones, David T. W. Feuerbach, Lars Division of Applied Bioinformatics German Cancer Research Center (DKFZ) 69120 Heidelberg Germany Faculty of Biosciences Heidelberg University 69120 Heidelberg Germany Division of Applied Bioinformatics German Cancer Research Center (DKFZ) Heidelberg Germany Faculty of Biosciences Heidelberg University Heidelberg Germany Division of Theoretical Bioinformatics German Cancer Research Center (DKFZ) 69120 Heidelberg Germany Department for Bioinformatics and Functional Genomics Institute for Pharmacy and Molecular Biotechnology (IPMB) and BioQuant 69120 Heidelberg Germany Division of Theoretical Bioinformatics German Cancer Research Center (DKFZ) Heidelberg Germany Institute of Pharmacy and Molecular Biotechnology and BioQuant Heidelberg University Heidelberg Germany German Cancer Consortium (DKTK) Heidelberg Germany National Center for Tumor Diseases (NCT) Heidelberg Heidelberg Germany Heidelberg Center for Personalized Oncology (DKFZ-HIPO) German Cancer Research Center (DKFZ) Heidelberg Germany German Cancer Consortium (DKTK) German Cancer Research Center (DKFZ) Heidelberg Germany Division of Chromatin Networks German Cancer Research Center (DKFZ) and BioQuant 69120 Heidelberg Germany Department of Biomedical Informatics Harvard Medical School Boston Massachusetts 02115 USA Department of Chemistry Centre for Molecular Science Informatics University of Cambridge Cambridge CB2 1EW UK Ludwig Center at Harvard Medical School Boston Massachusetts 02115 USA Department of Biomedical Informatics Harvard Medical School Boston MA USA Department of Chemistry Centre for Molecular Science Informatics University of Cambridge Cambridge UK Ludwig Center at Harvard Medical School Boston MA USA School of Mathematical Sciences and Center for Statistical Science Peking University Beijing 100871 China Heidelberg University Heidelberg Germany New BIH Digital Health Center Berlin Institute of Health (BIH) and Charité - Universitätsmedizin Berlin Berlin Germany Bioi

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The Hyper-Kamiokande experiment - snowmass LOI

arXiv

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arXiv 2020年

作者： Abe, K. Adrich, P. Aihara, H. Akutsu, R. Alekseev, I. Ali, A. Ameli, F. Anthony, L.H.V. Araya, A. Asaoka, Y. Aushev, V. Bandac, I. Barbi, M. Barr, G. Batkiewicz-Kwasniak, M. Bellato, M. Berardi, V. Bernard, L. Bernardini, E. Berns, L. Bhadra, S. Bian, J. Blanchet, A. Blondel, A. Boiano, A. Bolognesi, S. Bonavera, L. Borjabad, S. Boschi, T. Bose, D. Boyd, S.B. Bozza, C. Bravar, A. Bronner, C. Bubak, A. Buchowicz, A. Avanzini, M. Buizza Cafagna, F.S. Calabria, N.F. Calvo-Mozota, J.M. Cao, S. Catanesi, M.G. Chakraborty, S. Choi, J.H. Choubey, S. Cicerchia, M. Coleman, J. Collazuol, G. Cuen-Rochin, S. Danilov, M. Fuente, E. De la de Perio, P. de Rosa, G. Dealtry, T. Densham, C.J. Dergacheva, A. Deshmukh, N. Devi, M.M. Di Lodovico, F. Di Meo, P. Di Palma, I. Doyle, T.A. Drakopoulou, E. Drapier, O. Dumarchez, J. Eklund, L. El Hedri, S. Ellis, J. Emery, S. Esmaili, A. Fedotov, S. Feng, J. Fernández-Martinez, E. Ferrario, P. Ferrazzi, B. Finch, A. Finley, C. Fiorillo, G. Fitton, M. Friend, M. Fujii, Y. Fukuda, Y. Galinski, G. Gao, J. Garde, C. Garfagnini, A. Garode, S. Gialanella, L. Giganti, C. Gomez-Cadenas, J.J. Gonin, M. González-Nuevo, J. Gorin, A. Gornea, R. Gramegna, F. Grassi, M. Grella, G. Guigue, M. Hadley, D.R. Harada, M. Hartz, M. Hassani, S. Hastings, N.C. Hayato, Y. Hiraide, K. Hoshina, K. Hultqvist, K. Iacob, F. Ichikawa, A.K. Ibnsalih, W. Idrissi Ikeda, M. Inomoto, M. Ioannisian, A. Ishida, T. Ishidoshiro, K. Ishino, H. Ishitsuka, M. Ito, H. Ito, S. Itow, Y. Iwamoto, K. Izumi, N. Izumiyama, S. Jakkapu, M. Jamieson, B. Jang, J.S. Jo, H.S. Jonsson, P. Joo, K.K. Kajita, T. Kakuno, H. Kameda, J. Kano, Y. Karlen, D. Kataoka, Y. Kato, A. Katori, T. Kazarian, N. Khabibullin, M. Khotjantsev, A. Kikawa, T. Kim, J.Y. Kim, S.B. King, S. Kinoshita, T. Kisiel, J. Klekotko, A. Kobayashi, T. Koerich, L. Kolev, N. Konaka, A. Kormos, L.L. Koshio, Y. Kotsar, Y. Kouzakov, K.A. Kowalik, K.L. AGH University of Science and Technology Faculty of Computer Science Electronics and Telecommunications Krakow Poland British Columbia Institute of Technology Physics Department BurnabyBC Canada Università della Campania"L. Vanvitelli" INFN Sezione di Napoli Napoli Italy Carleton University Department of Physics OttawaON Canada University of California Irvine Department of Physics and Astronomy IrvineCA United States Charles University IPNP FMF Prague Czech Republic Chonnam National University Department of Physics Gwangju Korea Republic of Dongshin University Laboratory for High Energy Physics Naju Korea Republic of Donostia International Physics Center Ikerbasque Foundation Basque Country Spain Ecole Polytechnique IN2P3-CNRS Laboratoire Leprince-Ringuet Palaiseau France University of Edinburgh School of Physics and Astronomy Edinburgh United Kingdom ETH Zurich Institute for Particle and Astroparticle Physics Zurich Switzerland University of Geneva Section de Physique DPNC Geneva Switzerland GIST College Gwangju Institute of Science and Technology Gwangju Korea Republic of University of Glasgow School of Physics and Astronomy Glasgow United Kingdom Universidad de Guadalajara CUCEA IT.Ph.D. program GuadalajaraJal Mexico Universidad de Guadalajara CUCEI Departamento de Fisica GuadalajaraJal Mexico H. Niewodniczá nski Institute of Nuclear Physics PAN Cracow Poland Imperial College London Department of Physics London United Kingdom Indian Institute of Technology Guwahati Guwahati India Indian Institute of Technology Jodhpur Department of Physics Karwar Rajasthan India Indian Institute of Technology Kharagpur Department of Physics Kharagpur India INFN Gruppo Collegato di Salerno Fisciano Italy INFN Laboratori Nazionali di Legnaro LegnaroPD Italy INFN Sezione di Bari Università e Politecnico di Bari Bari Italy INFN Sezione di Napoli Università Federico II di Napoli Dipartimento di Fisica Napoli Italy INFN Sezione di Napoli Nap

Hyper-Kamiokande is the next generation underground water Cherenkov detector that builds on the highly successful Super-Kamiokande experiment. The detector which has an 8.4 times larger effective volume than its predecessor will be located along the T2K neutrino beamline and utilize an upgraded J-PARC beam with 2.6 times beam power. Hyper-K’s low energy threshold combined with the very large fiducial volume make the detector unique, that is expected to acquire an unprecedented exposure of 3.8 Mton·year over a period of 20 years of operation. Hyper-Kamiokande combines an extremely diverse science program including nucleon decays, long-baseline neutrino oscillations, atmospheric neutrinos, and neutrinos from astrophysical origins. The scientific scope of this program is highly complementary to liquid-argon detectors for example in sensitivity to nucleon decay channels or supernova detection modes. Hyper-Kamiokande construction has started in early 2020 and the experiment is expected to start operations in 2027. The Hyper-Kamiokande collaboration is presently being formed amongst groups from 19 countries including the United States, whose community has a long history of making significant contributions to the neutrino physics program in Japan. US physicists have played leading roles in the Kamiokande, Super-Kamiokande, EGADS, K2K, and T2K programs. Copyright © 2020, The Authors. All rights reserved.

关键词： Atomic physics

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