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Combination of curcumin or chitosan with photodynamic therapy as an effective alternative therapy for overcoming wound infection associated with multidrug-resistant Acinetobacter baumannii

Microbe (Netherlands)

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Microbe (Netherlands) 2025年 7卷

作者： Yonpiam, Manta Wannigama, Dhammika Leshan Shein, Aye Mya Sithu Liao, Tingting Hurst, Cameron Monk, Peter N. Amarasiri, Mohan Phattharapornjaroen, Phatthranit Ounjai, Puey Saethang, Thammakorn Badavath, Vishnu Nayak Luk-in, Sirirat Nilgate, Sumanee Rirerm, Ubolrat Srisakul, Sukrit Ngamwongsatit, Natharin Leelahavanichkul, Asada Ragupathi, Naveen Kumar Devanga Kanjanabuch, Talerngsak Narkban, Phurin Miyanaga, Kazuhiko Cui, Longzhu Boontaveeyuwat, Einapak Higgins, Paul G. Kicic, Anthony Hamamoto, Hiroshi Abe, Shuichi Hongsing, Parichart Chatsuwan, Tanittha Department of Microbiology Faculty of Medicine Chulalongkorn University King Chulalongkorn Memorial Hospital Thai Red Cross Society Bangkok Thailand Center of Excellence in Antimicrobial Resistance and Stewardship Research Faculty of Medicine Chulalongkorn University Bangkok Thailand Dual degree Medical Science program Faculty of Medicine Chulalongkorn University Bangkok 10330 Thailand Department of Infectious Diseases and Infection Control Yamagata Prefectural Central Hospital Yamagata Japan School of Medicine Faculty of Health and Medical Sciences The University of Western Australia Nedlands WA Australia Biofilms and Antimicrobial Resistance Consortium of ODA receiving countries The University of Sheffield Sheffield United Kingdom Pathogen Hunter's Research Team Department of Infectious Diseases and Infection Control Yamagata Prefectural Central Hospital Yamagata Japan Department of Infectious Diseases Faculty of Medicine Yamagata University Yamagata Japan Department of Clinical Epidemiology Faculty of Medicine Thammasat University Rangsit 10120 Thailand Department of Infection Immunity & Cardiovascular Disease University of Sheffield Medical School United Kingdom Department of Civil and Environmental Engineering Graduate School of Engineering Tohoku University Miyagi Japan Faculty of Health Science Technology Chulabhorn Royal Academy Bangkok 10210 Thailand HRH Princess Chulabhorn Disaster and Emergency Medicine Center Chulabhorn Royal Academy Bangkok 10210 Thailand Department of Biology Faculty of Science Mahidol University Bangkok Thailand Department of Computer Science Faculty of Science Kasetsart University Bangkok Thailand School of Pharmacy & Technology Management SVKM's Narsee Monjee Institute of Management Studies (NMIMS) Hyderabad 509301 India Department of Clinical Microbiology and Applied Technology Faculty of Medical Technology Mahidol University Bangkok Thailand Department of Clinical Sciences and Public Health Faculty of Veteri

The increasing prevalence of multidrug-resistant Acinetobacter baumannii as an opportunistic pathogen in wound infections raises significant concerns due to its antibiotic resistance and biofilm-mediated antibiotic tolerance. This underscores the urgent need to explore an alternative approach to effectively managing wound infections caused by MDR A. baumannii. In this study, combining subinhibitory concentrations of curcumin (25 µg/ml) or chitosan (156 µg/ml) with photodynamic therapy-PDT (10 J/cm²) resulted in a significant reduction of planktonic viabilities and biofilm biovolume of MDR A. baumannii clinical isolates in vitro. In murine A. baumannii-associated wound infection, a combination of curcumin (25 µg/ml) or chitosan (156 µg/ml) with PDT (10 J/cm²) resulted in complete bacterial eradication with wound healing at Day 15 of post-treatments with these combination therapies. Our study demonstrated that combining curcumin or chitosan with PDT at their subinhibitory concentrations represents a promising alternative strategy as localized therapy for effectively managing A. baumannii-associated wound infection. © 2025 The Authors

关键词： Acinetobacter baumannii Alternative therapy Biofilm eradication Chitosan Curcumin Multidrug-resistant (MDR) Photodynamic therapy (PDT) Wound infection

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Carbon sequestration in mangrove ecosystems: Sources, transportation pathways, influencing factors, and its role in the carbon budget

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Earth-science Reviews 2025年 269卷

作者： Shafiqa Ali Gobinda Dey Nguyen Hoang Kim Nuong Abdur Rahman Liang-Chi Wang Uttara Sukul Koyeli Das Raju Kumar Sharma Shan-Li Wang Chien Yen Chen Department of Earth and Environmental Sciences National Chung Cheng University 168 University Road Min-Hsiung Chiayi County 62102 Taiwan Doctoral Program in Science Technology Environment and Mathematics National Chung Cheng University 168 University Road Min-Hsiung Chiayi County 62102 Taiwan Department of Agricultural Chemistry National Taiwan University Taipei 106319 Taiwan Environment and Disaster Monitoring Center National Chung Cheng University Chiayi 621 Taiwan Department of Biomedical Sciences Graduate Institute of Molecular Biology National Chung Cheng University 168 University Road Ming-Shung Chiayi County 62102 Taiwan Department of Chemistry and Biochemistry National Chung Cheng University 168 University Road Min-Hsiung Chiayi County 62102 Taiwan Center for Nano Bio-Detection Center for Innovative Research on Aging Society AIM-HI National Chung Cheng University 168 University Road Min-Hsiung Chiayi County 62102 Taiwan You-Cheng Engineering & Technology Co. Ltd 168 University Road Min-Hsiung Chiayi County 62102 Taiwan

Global efforts to mitigate climate change emphasize the critical need to reduce atmospheric CO₂ levels and enhance carbon sinks. Mangrove ecosystems, renowned for their substantial carbon sequestration capacity, play a vital role in sequestering significant amounts of carbon. This review explores carbon fluxes in mangrove ecosystems, emphasizing autochthonous and allochthonous carbon sequestration mechanisms. Specifically, it discusses the pathways through which carbon is absorbed and stored, including biological productivity, sediment accumulation, and carbonate precipitation. Furthermore, the role of microbial communities and root systems in carbon stabilization, nutrient cycling, and methane oxidation is also examined, highlighting their significance in enhancing sequestration efficiency. Moreover, this study evaluates the factors influencing carbon sequestration efficiency in mangroves and the methods used for its quantification. Finally, this review assesses the contribution of mangroves to the global carbon budget, emphasizing their strategic role in offsetting atmospheric CO 2 and enhancing coastal ecosystem resilience. However, significant research gaps remain in understanding the mechanism of carbon transformation, the interaction between diverse carbon sources, sediment dynamics, and long-term stability of buried organic matter across varying mangrove settings.

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The missing link in engineering education: The arts and humanities 25

The missing link in engineering education: The arts and huma...

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25th International Conference on Computers in Education: technology and Innovation: Computer-Based Educational Systems for the 21st Century, ICCE 2017

作者： Drew, David E. Bucciarelli, Louis L. School of Educational Studies Claremont Graduate University United States Program in Science Technology and Society Massachusetts Institute of Technology United States

ISBN: (纸本)9789869401227

We suggest that engineering education would benefit from a closer integration with the arts and humanities: to improve the design process, to attract a more diverse student body, and to sensitize students to the social impact of technology. Conversely, in today's high-tech environment, the liberal arts would be strengthened by introducing students to engineering concepts. We propose a program, Liberal Studies in Engineering, and outline its key components. Creating this interdisciplinary program in higher education requires confronting and transcending academic silos. © 2017 Asia-Pacific society for Computers in Education. All rights reserved.

关键词： Engineering education

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Freshwater microalgae-mediated engineered nanoparticles: Sustainable approach for heavy metals remediation

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Bioresource technology 2025年 434卷 132761页

作者： Manish Sutradhar Raju Kumar Sharma Gobinda Dey Uttara Sukul Koyeli Das Md Taharia Pin-Yun Lin Shafiqa Ali Chin-Wen Wang Chien-Yen Chen Doctoral Program in Science Technology Environment and Mathematics Department of Earth and Environmental Sciences National Chung Cheng University 168 University Road Min-Hsiung Chiayi County 62102 Taiwan Department of Earth and Environmental Sciences National Chung Cheng University 168 University Road Min-Hsiung Chiayi County 62102 Taiwan. Department of Chemistry and Biochemistry National Chung Cheng University 168 University Road Min-Hsiung Chiayi County 62102 Taiwan Center for Nano Bio-Detection Center for Innovative Research on Aging Society AIM-HI National Chung Cheng University 168 University Road Min-Hsiung Chiayi County 62102 Taiwan. Department of Biomedical Sciences Graduate Institute of Molecular Biology National Chung Cheng University 168 University Road Min-Hsiung Chiayi County 62102 Taiwan. Department of Chemistry and Biochemistry National Chung Cheng University 168 University Road Min-Hsiung Chiayi County 62102 Taiwan. Department of Earth and Environmental Sciences National Chung Cheng University 168 University Road Min-Hsiung Chiayi County 62102 Taiwan Center for Nano Bio-Detection Center for Innovative Research on Aging Society AIM-HI National Chung Cheng University 168 University Road Min-Hsiung Chiayi County 62102 Taiwan You-Cheng Engineering & Technology Co. Ltd 168 University Road Min-Hsiung Chiayi Country 62102 Taiwan. Electronic address: yen@eq.ccu.edu.tw.

Recently, convergence of nanotechnology and sustainable approaches has emerged as promising strategy for advanced remediation of heavy metals (HMs) from water. However, engineered nanoparticles (ENPs)-derived from freshwater microalgae gained attention as viable alternative, owing their inherent metal tolerance, rapid-growth rates, and versatile metabolic capabilities. This review predominantly focuses on freshwater microalgae-mediated-ENPs, highlighting intracellular/extracellular pathways induced by biomolecules such as polysaccharides, proteins, lipids, reductases etc., which govern nanoparticle nucleation, stabilization, and functionalization. Subsequently, the review discusses significant types of ENPs including iron, silver, gold, cadmium-sulfide, iron-oxide, nanocomposites, and bio-nano-hybrids nanoparticles, which reported removal efficiency from 21 to 100% of different HMs (lead, cadmium, chromium, copper, zinc, etc.). Despite ENPs exhibit significant potential, their large-scale implementation is constrained by challenges such as scaling-up, nutrient-variability, and high turbidity of wastewater. Future research recommended to focus on optimizing biosynthesis parameters, investigating diverse microalgal-strains, incorporating hybrid nano-materials to enhance their stability, reusability, and scalability for sustainable green-technology.

关键词： Bio-nanotechnology Bioremediation efficiency Environmental nano-materials Green synthesis Heavy metal removal Phytoremediation

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Global tracking of marine megafauna space use reveals how to achieve conservation targets

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science (New York, N.Y.) 2025年第6751期388卷 1086-1097页

作者： Ana M M Sequeira Jorge P Rodríguez Sarah A Marley Hannah J Calich Mirjam van der Mheen Michelle VanCompernolle Lucy M Arrowsmith Lauren R Peel Nuno Queiroz Marisa Vedor Ivo da Costa Gonzalo Mucientes Ana Couto Nicolas E Humphries Sara Abalo-Morla Francisco J Abascal Debra L Abercrombie Katya Abrantes F Alberto Abreu-Grobois André S Afonso Pedro Afonso Heidi Ahonen Susanne Åkesson Joanna Alfaro-Shigueto Russel D Andrews Frédéric Angelier Marina Antonopoulou Javier A Arata Gonzalo Araujo Randall Arauz José Manuel Arcos Igor Arregui Haritz Arrizabalaga Marie Auger-Méthé Steffen Bach Fred Bailleul Robin W Baird George H Balazs Susan G Barco Adam Barnett Warren Baverstock Alastair M M Baylis Annalea Beard Juan Bécares Eduardo J Belda Ian Bell Ashley Bennison Scott R Benson Diego Bernal Michael L Berumen Sandra Bessudo Natalia P A Bezerra Antonin V Blaison Gabriela S Blanco Barbara A Block Mark Bolton Mark E Bond Ramón Bonfil Camrin D Braun Annette C Broderick Michael de L Brooke Annabelle M L Brooks Edward J Brooks Ignacio M Bruno Jennifer M Burns Michael E Byrne Steven E Campana Hamish A Campbell Richard A Campbell Aaron Carlisle Ruth H Carmichael Gemma Carroll Paolo Casale Filipe R Ceia Demian D Chapman Taylor K Chapple Jean-Benoit Charrassin Andre Chiaradia John Chisholm Christopher R Clarke Thomas A Clay Christophe Cleguer Elizabeth Clingham Eric E G Clua Jesse E M Cochran Rochelle Constantine Robert W Cooper Estelle Crochelet Michelle Cronin Eduardo Cuevas Kayla P DaCosta Laurent Dagorn Ryan Daly Randall W Davis P J Nico de Bruyn Carlos Delgado-Trejo Thomas Dellinger Solène Derville Stella Diamant Andrew DiMatteo Kara L Dodge Philip D Doherty Michael C Double Alistair D M Dove Thomas K Doyle Michael J Drew Lindsay L Dubbs Clinton A J Duffy Peter H Dutton Ewan W J Edwards Luke D Einoder Mark V Erdmann Eduardo Espinoza Nicole Esteban Ana Isabel Fagundes Chris Feare Steven H Ferguson Luciana C Ferreira Francesco Ferretti John Filmalter Brittany Finucci G Chris Fischer Richard J Fitzpatrick Jorge Fontes Angela Formia Division of Ecology and Evolution Research School of Biology The Australian National University Canberra (Australian Capital Territory) Australia. UWA Oceans Institute and the School of Biological Sciences The University of Western Australia Perth (Western Australia) Australia. Instituto de Física Interdisciplinar y Sistemas Complejos (IFISC) CSIC-UIB Palma de Mallorca Spain. Instituto Mediterráneo de Estudios Avanzados (IMEDEA) CSIC-UIB Esporles Illes Balears Spain. C.A. Illes Balears Universidad Nacional de Educación a Distancia (UNED) Palma Spain. Delegación Territorial en Illes Balears Agencia Estatal de Meteorología (AEMET) Muelle de Poniente s/n Palma Spain. Scotland's Rural College (SRUC) Craibstone Estate Bucksburn Aberdeen UK. Oceans Graduate School and the UWA Oceans Institute The University of Western Australia Perth (Western Australia) Australia. School of Engineering and the UWA Oceans Institute The University of Western Australia Perth (Western Australia) Australia. Department of Biodiversity Conservation and Attractions Biodiversity and Conservation Science Kensington (Western Australia) Australia. Save Our Seas Foundation Geneva Switzerland. The Manta Trust Catemwood House Norwood Lane Corscombe Dorset UK. Centro de Investigação em Biodiversidade e Recursos Genéticos (CIBIO) InBIO Laboratório Associado Campus de Vairão Universidade do Porto Vairão Portugal. BIOPOLIS Program in Genomics Biodiversity and Land Planning Campus de Vairao Vairão Portugal. Instituto de Investigaciones Marinas Consejo Superior de Investigaciones Científicas (IIM-CSIC) Vigo Pontevedra Spain. School of Biological Sciences University of Aberdeen Aberdeen UK. Biomathematics and statistics Scotland The kings building Edinburgh Scotland. Marine Biological Association (MBA) The Laboratory Citadel Hill Plymouth UK. Instituto de Investigación para la Gestión Integrada de Zonas Costeras Universitat Politècnica de València Gandia València Spain. Instituto Español de O

The recent Kunming-Montreal Global Biodiversity Framework (GBF) sets ambitious goals but no clear pathway for how zero loss of important biodiversity areas and halting human-induced extinction of threatened species will be achieved. We assembled a multi-taxa tracking dataset (11 million geopositions from 15,845 tracked individuals across 121 species) to provide a global assessment of space use of highly mobile marine megafauna, showing that 63% of the area that they cover is used 80% of the time as important migratory corridors or residence areas. The GBF 30% threshold (Target 3) will be insufficient for marine megafauna's effective conservation, leaving important areas exposed to major anthropogenic threats. Coupling area protection with mitigation strategies (e.g., fishing regulation, wildlife-traffic separation) will be essential to reach international goals and conserve biodiversity.

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INTRODUCTION

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Bulletin of the American Meteorological society 2024年第8期105卷 S1-S11页

作者： Boyer, T. Blunden, J. Dunn, R.J.H. NOAA/NESDIS National Centers for Environmental Information Silver Spring Maryland NOAA/NESDIS National Centers for Environmental Information Asheville North Carolina Met Office Hadley Centre Exeter United Kingdom European Centre for Medium-Range Weather Forecasts Reading United Kingdom University of Maryland College Park Maryland Scripps Institution of Oceanography University of California San Diego La Jolla California NOAA/NWS National Centers for Environmental Prediction Climate Prediction Center College Park Maryland Brandenburg University of Technology (BTU) Cottbus-Senftenberg Germany Servicio Meteorológico Nacional Buenos Aires Argentina NOAA/OAR Physical Sciences Laboratory Boulder Colorado European Centre for Medium-Range Weather Forecasts Bonn Germany Center for Geophysical Research and School of Physics University of Costa Rica San José Costa Rica Department of Meteorology and National Centre for Earth Observation University of Reading Reading United Kingdom Centro Nacional de Monitoramento e Alertas de Desastres Naturais CEMADEN São Paulo Brazil Université Grenoble Alpes Institut des Géosciences de l’Environnement IRD CNRS Grenoble INP Grenoble France Hampton University Hampton Virginia Seychelles Meteorological Authority Mahe Seychelles Section for Glaciers Ice and Snow Norwegian Water Resources and Energy Directorate Oslo Norway National Research Institute for Agriculture Food and Environment (INRAE) CARRTEL Université Savoie Mont Blanc Thonon les Bains France Graduate School of Agriculture Osaka Metropolitan University Sakai Japan Science Faculty Universidad Nacional de Colombia Bogotá Colombia University of Bremen Bremen Germany NOAA Global Monitoring Laboratory Boulder Colorado Servicio Nacional de Meteorología e Hidrología del Perú Lima Perú Centro de Investigaciones sobre Desertificación – Spanish National Research Council (CSIC-UV-GVA) Valencia Spain Hydro-Climate Extremes Lab (H-CEL) Ghent University Ghent Belgium Department o

In 2023, La Niña conditions that generally prevailed in the eastern Pacific Ocean from mid-2020 into early 2023 gave way to a strong El Niño by October. Atmospheric concentrations of Earth’s major greenhouse gases—carbon dioxide, methane, and nitrous oxide—all increased to record-high levels. The annual global average carbon dioxide concentration in the atmosphere rose to 419.3±0.1 ppm, which is 50% greater than the pre-industrial level. The growth from 2022 to 2023 was 2.8 ppm, the fourth highest in the record since the 1960s. The combined short-term effects of El Niño and the long-term effects of increasing levels of heat-trapping gases in the atmosphere contributed to new records for many essential climate variables reported here. The annual global temperature across land and oceans was the highest in records dating as far back as 1850, with the last seven months (June–December) having each been record warm. Over land, the globally averaged temperature was also record high. Dozens of countries reported record or near-record warmth for the year, including China and continental Europe as a whole (warmest on record), India and Russia (second warmest), and Canada (third warmest). Intense and widespread heatwaves were reported around the world. In Vietnam, an all-time national maximum temperature record of 44.2°C was observed at Tuong Duong on 7 May, surpassing the previous record of 43.4°C at Huong Khe on 20 April 2019. In Brazil, the air temperature reached 44.8°C in Araçuaí in Minas Gerais on 20 November, potentially a new national record and 12.8°C above normal. The effect of rising temperatures was apparent in the cryosphere, where snow cover extent by June 2023 was the smallest in the 56-year record for North America and seventh smallest for the Northern Hemisphere overall. Heatwaves contributed to the greatest average mass balance loss for Alpine glaciers around the world since the start of the record in 1970. Due to rapid volume loss beginning in 2021, St. A

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A New Master Supernovae Ia sample and the investigation of the Hubble tension

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Journal of High Energy Astrophysics 2025年 48卷

作者： M.G. Dainotti B. De Simone A. Garg K. Kohri A. Bashyal A. Aich A. Mondal S. Nagataki G. Montani T. Jareen V.M. Jabir S. Khanjani M. Bogdan N. Fraija A.C.C. do E.S. Pedreira R.H. Dejrah A. Singh M. Parakh R. Mandal K. Jarial H. Sarkar Division of Science National Astronomical Observatory of Japan 2 Chome-21-1 Osawa Mitaka Tokyo 181-8588 Japan The Graduate University for Advanced Studies SOKENDAI Shonankokusaimura Hayama Miura District Kanagawa 240-0115 Japan Space Science Institutes 4765 Walnut St Ste B Boulder 80301 CO USA Nevada Center for Astrophysics University of Nevada 89154 4505 Maryland Parkway Las Vegas 80301 NV USA Dipartimento di Fisica “E.R. Caianiello” Università di Salerno Via Giovanni Paolo II 132 Fisciano Salerno 84084 Italy INFN Gruppo Collegato di Salerno - Sezione di Napoli. c/o Dipartimento di Fisica “E.R. Caianiello” Università di Salerno Via Giovanni Paolo II 132 Fisciano Salerno 84084 Italy Department of Astronomy Astrophysics and Space Engineering Indian Institute of Technology Indore Madhya Pradesh 403552 India Theory Center IPNS and QUP (WPI) KEK 1-1 Oho Tsukuba 305-0801 Japan Kavli IPMU (WPI) UTIAS The University of Tokyo Kashiwa Chiba 277-8583 Japan Central Department of Physics Tribhuvan University Kirtipur Kathmandu 44618 Nepal Pokhara Astronomical Society Pokhara 33700 Nepal Prayoga Institute of Education Research Kanakapura Rd off Ravgodlu Post Bengaluru 560082 Karnataka India Indian Institute of Science Education and Research Homi Bhabha Road Pashan Pune Maharashtra 411008 India Astrophysical Big Bang Laboratory (ABBL) RIKEN Cluster for Pioneering Research 2-1 Hirosawa Wako Saitama 351-0198 Japan RIKEN Interdisciplinary Theoretical & Mathematical Science Program (iTHEMS) 2-1 Hirosawa Wako Saitama 351-0198 Japan Astrophysical Big Bang Group (ABBG) Okinawa Institute of Science and Technology (OIST) 1919-1 Tancha Onna-son Kunigami-gun Okinawa 904-0495 Japan Physics Department “Sapienza” University of Rome P.le Aldo Moro 5 Rome 00185 Italy ENEA Fusion and Nuclear Safety Department C.R. Frascati Via E. Fermi 45 Frascati 00044 Italy The Thanu Padmanabhan Centre for Cosmology and Science Popularization Gurugram

Modern cosmological research still thoroughly debates the discrepancy between local probes and the Cosmic Microwave Background observations in the Hubble constant ( H 0 ) measurements, ranging from 4 to 6 σ . In the current study, we examine this tension using the Supernovae Ia (SNe Ia) data from the Pantheon, Pantheon+ (P+), Joint Lightcurve Analysis (JLA), and Dark Energy Survey, (DES) catalogs combined together into the so-called Master Sample. The sample contains 3714 SNe Ia, and is divided all of them into redshift-ordered bins. Three binning techniques are presented: the equi-population, the moving window (MW), and the equi-spacing in the log ⁡ − z . We perform a Markov-Chain Monte Carlo analysis (MCMC) for each bin to determine the H 0 value, estimating it within the standard flat ΛCDM and the w 0 w a CDM models. These H 0 values are then fitted with the following phenomenological function: H 0 ( z ) = H ˜ 0 / ( 1 + z ) α , where H ˜ 0 is a free parameter representing H 0 ( z ) fitted in z = 0 , and α is the evolutionary parameter. Our results indicate a decreasing trend characterized by α ∼ 0.01 , whose consistency with zero ranges from 1 σ in 5 cases to 1 case at 3 σ and 11 cases at > 3 σ in several samples and configurations. Such a trend in the SNe Ia catalogs could be due to evolution with redshift for the astrophysical variables or unveiled selection biases. Alternatively, intrinsic physics, possibly the f ( R ) theory of gravity, could be responsible for this trend.

关键词： Cosmology Hubble constant Hubble tension SNe Ia

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TOI-2015 b: a sub-Neptune in strong gravitational interaction with an outer non-transiting planet

arXiv

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arXiv 2025年

作者： Barkaoui, K. Korth, J. Gaidos, E. Agol, E. Parviainen, H. Pozuelos, F.J. Palle, E. Narita, N. Grimm, S. Brady, M. Bean, J.L. Morello, G. Rackham, B.V. Burgasser, A.J. Van Grootel, V. Rojas-Ayala, B. Seifahrt, A. Marfil, E. Passegger, V.M. Stalport, M. Gillon, M. Collins, K.A. Shporer, A. Giacalone, S. Yalçınkaya, S. Ducrot, E. Timmermans, M. Triaud, A.H.M.J. de Wit, J. Soubkiou, A. Watkins, C.N. Aganze, C. Alonso, R. Amado, P.J. Basant, R. Baştürk, Ö. Benkhaldoun, Z. Burdanov, A. Calatayud-Borras, Y. Chouqar, J. Conti, D.M. Collins, K.I. Davoudi, F. Delrez, L. Dressing, C.D. de Leon, J. Dévora-Pajares, M. Demory, B.O. Dransfield, G. Esparza-Borges, E. Fernández-Rodriguez, G. Fukuda, I. Fukui, A. Gallardo, P.P.M. Garcia, L. Garcia, N.A. Ghachoui, M. Geraldía-González, S. Chew, Y. Gómez Maqueo González-Rodríguez, J. Günther, M.N. Hayashi, Y. Horne, K. Hooton, M.J. Hsu, C.C. Ikuta, K. Isogai, K. Jehin, E. Jenkins, J.M. Kawauchi, K. Kagetani, T. Kawai, Y. Kasper, D. Kielkopf, J.F. Klagyivik, P. Lacedelli, G. Latham, D.W. Libotte, F. Luque, R. Livingston, J.H. Mancini, L. Massey, B. Mori, M. Torres, S. Muñoz Murgas, F. Niraula, P. Orell-Miquel, J. Rapetti, David Rebolo-López, R. Ricker, G. Papini, R. Pedersen, P.P. Peláez-Torres, A. Pérez-Prieto, J.A. Poultourtzidis, E. Rodriguez, P.M. Queloz, D. Savel, A.B. Schanche, N. Sánchez-Benavente, M. Sibbald, L. Sefako, R. Sohy, S. Sota, A. Schwarz, R.P. Seager, S. Sebastian, D. Southworth, J. Stangret, M. Stefánsson, G. Stürmer, J. Srdoc, G. Thompson, S.J. Terada, Y. Vanderspek, R. Wang, G. Watanabe, N. Wilkin, F.P. Winn, J. Wells, R.D. Ziegler, C. Zúñiga-Fernández, S. Astrobiology Research Unit Université de Liège Allée du 6 Août 19C LiègeB-4000 Belgium Department of Earth Atmospheric and Planetary Science Massachusetts Institute of Technology 77 Massachusetts Avenue CambridgeMA02139 United States Calle Vía Láctea s/n Tenerife La Laguna38200 Spain Lund Observatory Division of Astrophysics Department of Physics Lund University Box 118 Lund22100 Sweden Department of Earth Sciences University of Hawaii at Manoa 1680 East-West Rd HonoluluHI96822 United States Institute for Astrophysics University of Vienna Türkenschanzstrasse 17 ViennaA-1180 Austria Department of Astronomy Astrobiology Program University of Washington Box 351580 SeattleWA98195 United States NExSS Virtual Planetary Laboratory University of Washington Box 351580 SeattleWA98195 United States Tenerife La LagunaE-38206 Spain Glorieta de la Astronomía s/n Granada18008 Spain INAF- Palermo Astronomical Observatory Piazza del Parlamento 1 Palermo90134 Italy Komaba Institute for Science The University of Tokyo 3-8-1 Komaba Meguro Tokyo153-8902 Japan Astrobiology Center 2-21-1 Osawa Mitaka Tokyo181-8588 Japan Research Institute for Advanced Computer Science Universities Space Research Association WashingtonDC20024 United States Institute for Particle Physics and Astrophysics ETH Zürich OttoStern-Weg 5 Zürich8093 Switzerland Department of Astrophysics University of Zürich Winterthurerstrasse 190 Zürich8057 Switzerland Department of Astronomy & Astrophysics University of Chicago ChicagoIL United States NHFP Sagan Fellow United States Department of Physics Kavli Institute for Astrophysics and Space Research Massachusetts Institute of Technology CambridgeMA02139 United States Institute Université de Liège Allée du 6 Août 19C LiègeB-4000 Belgium Instituto de Alta Investigación Universidad de Tarapacá Casilla 7D Arica Chile Gemini Observatory NSF NOIRLab 670 N. A’ohoku Place HiloHI96720 United States Departamento de

TOI-2015 is a known exoplanetary system around an M4 dwarf star, consisting of a transiting sub-Neptune planet in a 3.35-day orbital period, TOI-2015 b, accompanied by a non-transiting companion, TOI-2015 c. High-precision radial velocity measurements were taken with the MAROON-X spectrograph, and high-precision photometric data were collected, primarily using the SPECULOOS, MUSCAT, TRAPPIST and LCOGT networks. We collected 63 transit light curves and 49 different transit epochs for TOI-2015 b. We re-characterize the target star by combining optical spectra obtained by the MAROON-X, Shane/KAST and IRTF/SpeX spectrographs, Bayesian Model Averaging (BMA) and Spectral Energy Distribution (SED) analysis. The TOI-2015 host star is a K = 10.3 mag M4-type dwarf with a sub-solar metallicity of [e/H]= −0.31 ± 0.16, and an effective temperature of Teff ≈ 3200 K. Our photodynamical analysis of the system strongly favors the 5:3 mean motion resonance and in this scenario the planet b (TOI-2015 b) has an orbital period of Pb = 3.34 days, a mass of Mp = 9.02+0.32−0.36 M⊗, a radius of Rp = 3.309+0.013−0.11 R⊗, resulting in a density of ρp = 0.25±0.01 ρ⊗ = 1.40±0.06 g cm−3, indicative of a Neptune-like composition. Its transits exhibit large (> 1 hr) timing variations indicative of an outer perturber in the system. We performed a global analysis of the high-resolution radial-velocity measurements, the photometric data, and the TTVs, and inferred that TOI-2015 hosts a second planet, TOI-2015 c, in a non-transiting configuration. Our analysis places it near a 5:3 resonance with an orbital period of Pc = 5.583 days and a mass of Mp = 8.91+0.38−0.40 M⊗. The dynamical configuration of TOI-2015 b and TOI-2015 c can be used to constrain the system’s planetary formation and migration history. Based on the mass-radius composition models, TOI-2015 b is a water-rich or rocky planet with a hydrogen-helium envelope. Moreover, TOI-2015 b has a high transmission spectroscopic metric (TSM= 149), m

关键词： Stars

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Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the Global Burden of Disease Study 2021

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The Lancet 2023年第10397期402卷 203-234页

作者： Ong, Kanyin Liane Stafford, Lauryn K. McLaughlin, Susan A. Boyko, Edward J. Vollset, Stein Emil Smith, Amanda E. Dalton, Bronte E. Duprey, Joe Cruz, Jessica A. Hagins, Hailey Lindstedt, Paulina A. Aali, Amirali Abate, Yohannes Habtegiorgis Abate, Melsew Dagne Abbasian, Mohammadreza Abbasi-Kangevari, Zeinab Abbasi-Kangevari, Mohsen ElHafeez, Samar Abd Abd-Rabu, Rami Abdulah, Deldar Morad Abdullah, Abu Yousuf Md Abedi, Vida Abidi, Hassan Aboagye, Richard Gyan Abolhassani, Hassan Abu-Gharbieh, Eman Abu-Zaid, Ahmed Adane, Tigist Demssew Adane, Denberu Eshetie Addo, Isaac Yeboah Adegboye, Oyelola A. Adekanmbi, Victor Adepoju, Abiola Victor Adnani, Qorinah Estiningtyas Sakilah Afolabi, Rotimi Felix Agarwal, Gina Aghdam, Zahra Babaei Agudelo-Botero, Marcela Arriagada, Constanza Elizabeth Aguilera Agyemang-Duah, Williams Ahinkorah, Bright Opoku Ahmad, Danish Ahmad, Rizwan Ahmad, Sajjad Ahmad, Aqeel Ahmadi, Ali Ahmadi, Keivan Ahmed, Ali Ahmed, Luai A. Ahmed, Syed Anees Ajami, Marjan Akinyemi, Rufus Olusola Al Hamad, Hanadi Al Hasan, Syed Mahfuz AL-Ahdal, Tareq Mohammed Ali Alalwan, Tariq A. Al-Aly, Ziyad AlBataineh, Mohammad T. Alcalde-Rabanal, Jacqueline Elizabeth Alemi, Sharifullah Ali, Hassam Alinia, Tahereh Aljunid, Syed Mohamed Almustanyir, Sami Al-Raddadi, Rajaa M. Alvis-Guzman, Nelson Amare, Firehiwot Ameyaw, Edward Kwabena Amiri, Sohrab Amusa, Ganiyu Adeniyi Andrei, Catalina Liliana Anjana, Ranjit Mohan Ansar, Adnan Ansari, Golnoosh Ansari-Moghaddam, Alireza Anyasodor, Anayochukwu Edward Arabloo, Jalal Aravkin, Aleksandr Y. Areda, Demelash Arifin, Hidayat Arkew, Mesay Armocida, Benedetta Arnlov, Johan Artamonov, Anton A. Arulappan, Judie Aruleba, Raphael Taiwo Arumugam, Ashokan Aryan, Zahra Asemu, Mulu Tiruneh Asghari-Jafarabadi, Mohammad Askari, Elaheh Asmelash, Daniel Astell-Burt, Thomas Athar, Mohammad Athari, Seyyed Shamsadin Atout, Maha Moh'd Wahbi Avila-Burgos, Leticia Awaisu, Ahmed Azadnajafabad, Sina Darshan, B.B. Babamohamadi, Hassan Badar, Muhammad Badawi, Alaa Badiye, Ashish D. Baghcheghi, Nayereh Baghe Institute for Health Metrics and Evaluation School of Medicine General Medicine Service Department of Veterans Affairs Seattle WA United States Department of Health Metrics Sciences School of Medicine Faculty of Medicine France Department of Clinical Governance and Quality Improvement Aleta Wondo Hospital Aleta Wondo Ethiopia Department of Nursing Woldia University Woldia Ethiopia Department of Nursing Department of Orthopedic Surgery Orthopaedic Surgery Social Determinants of Health Research Center Non-communicable Diseases Research Center Epidemiology Department Evidence-Based Practice Center Community and Maternity Nursing Unit University of Duhok Duhok Iraq School of Planning Faculty of Environment Department of Public Health Sciences Penn State College of Medicine Pennsylvania State University Hershey PA United States Biocomplexity Institute Virginia Tech Blacksburg VA United States College of Medicine Department of Public Health Laboratory Technology Sciences Department Department of Family and Community Health University of Health and Allied Sciences Ho Ghana Research Center for Immunodeficiencies Department of Biosciences and Nutrition Karolinska University Hospital Huddinge Sweden Clinical Sciences Department Department of Surgery Department of Surgery Department of Obstetrics & Gynecology College of Graduate Health Sciences University of Tennessee Memphis TN United States Department of Obstetrics & Gynecology Department of Clinical and Psychosocial Epidemiology Department of Anesthesia and Critical Care Centre for Social Research in Health Quality and Systems Performance Unit Cancer Institute NSW Sydney NSW Australia Department of Public Health and Tropical Medicine HIV and Infectious Diseases Department Jhpiego Abuja Nigeria Adolescent Research and Care Department Adolescent Friendly Research Initiative and Care Ado Ekiti Nigeria Department of Epidemiology Department of Epidemiology and Medical Statistics Department of Family Medicine McMaster University

Background: Diabetes is one of the leading causes of death and disability worldwide, and affects people regardless of country, age group, or sex. Using the most recent evidentiary and analytical framework from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD), we produced location-specific, age-specific, and sex-specific estimates of diabetes prevalence and burden from 1990 to 2021, the proportion of type 1 and type 2 diabetes in 2021, the proportion of the type 2 diabetes burden attributable to selected risk factors, and projections of diabetes prevalence through 2050. Methods: Estimates of diabetes prevalence and burden were computed in 204 countries and territories, across 25 age groups, for males and females separately and combined;these estimates comprised lost years of healthy life, measured in disability-adjusted life-years (DALYs;defined as the sum of years of life lost [YLLs] and years lived with disability [YLDs]). We used the Cause of Death Ensemble model (CODEm) approach to estimate deaths due to diabetes, incorporating 25 666 location-years of data from vital registration and verbal autopsy reports in separate total (including both type 1 and type 2 diabetes) and type-specific models. Other forms of diabetes, including gestational and monogenic diabetes, were not explicitly modelled. Total and type 1 diabetes prevalence was estimated by use of a Bayesian meta-regression modelling tool, DisMod-MR 2.1, to analyse 1527 location-years of data from the scientific literature, survey microdata, and insurance claims;type 2 diabetes estimates were computed by subtracting type 1 diabetes from total estimates. Mortality and prevalence estimates, along with standard life expectancy and disability weights, were used to calculate YLLs, YLDs, and DALYs. When appropriate, we extrapolated estimates to a hypothetical population with a standardised age structure to allow comparison in populations with different age structures. We used the comparative r

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I see sick people: Beliefs about sensory detection of infectious disease are largely consistent across cultures

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Brain, Behavior, and Immunity 2025年 128卷 737-750页

作者： Ackerman, Joshua M. Samore, Theodore Fessler, Daniel M.T. Kupfer, Tom R. Choi, Soyeon Merrell, Wilson N. Aarøe, Lene Aavik, Toivo Acabado, Stephen Akello, Grace Alfian, Ilham N. Al-Shawaf, Laith Alvarez, Marinés M. Ammann, Jeanine Arikan, Gizem Asha, Saiyeda A. Astobiza, Anibal M. Baeza-Ugarte, Carmen G. Barclay, Pat Barlow, Fiona Kate Bizarro, Lisiane Bressan, Paola Castellanos-Chacón, Andres Choy, Bryan K.C. Chusairi, Achmad Contreras-Garduño, Jorge Chávez Cosamalón, Brenda L. Costa-Neves, Bernardo De, Mallika de Lima, Tiago J.S. de Zoysa, Piyanjali Dryžaitė, Ieva Elbæk, Christian T. Fedor, Peter Fernández, Ana M. Fernandez-Morales, Regina Fülöp, Márta Gamsakhurdia, Vladimer Lado Garcia-Gómez, Leonor Garcia-Marques, Leonel Garduño-Franco, Jimena Pilar Grazioso, María del Habacht, Fanny Hasan, Youssef Haugestad, Camila P. Haugestad, Christian A.P. Havlíček, Jan Hernandez, Earl J. Hoang, Vu M. Hong, Minsung Hromatko, Ivana Iliško, Dzintra Imada, Hirotaka Jakšić, Ivana Jarmakowski, Tomasz Hjördísar Jónsdóttir, Harpa L. Kajokaite, Kotrina Kaňková, Šárka Kervyn, Nicolas Kim, Jinseok P. Kunst, Jonas R. Laakasuo, Michael Leongómez, Juan David Li, Norman P. Lu, Junsong Lynch, Nathan Maegli, María A. Manley, Harry Marcu, Gabriela McAfee, Thea Mitkidis, Panagiotis Molnár, Nándor B. Morvinski, Coby Muhamad, Haslina Nejat, Pegah Huy, Hoang Nguyen Oliveira, Angelica N. Olsson, Mats J. Onyishi, Charity N. Onyishi, Ike E. Orozco, Reegan Otterbring, Tobias Ottersen, Ida S. Pacheco-López, Gustavo Panagiotopoulou, Penny Paniagua, Walter Parvin, Roksana Pavlović, Zoran Prokop, Pavol Raffman, Emma Rizwan, Muhammad Rojas, Sheila Różycka-Tran, Joanna Sánchez, Oscar R. Selim, Heyla Sevi, Barış Shani, Yaniv Shastry, Madhulika S. Stieger, Stefan Suh, Eunkook M. Sumari, Melati Takemura, Kosuke Tognetti, Arnaud Trombetta, Roberta Z.R. Tybur, Joshua M. Ucak, Eylul B. Uchida, Yukiko Valentova, Jaroslava V. Viciana, Hugo Visine, Amandine Wang, Jin Wang, XT Yahiiaiev, Illia I. Zein, Rizqy A. Žeželj, Iris Department of Psychology University of Michigan Ann Arbor MI United States Religion Programme University of Otago Dunedin New Zealand Department of Anthropology University of California Los Angeles Los Angeles CA United States Center for Behavior Evolution & Culture University of California Los Angeles Los Angeles CA United States Bedari Kindness Institute University of California Los Angeles Los Angeles CA United States Department of Psychology Nottingham Trent University England Nottingham United Kingdom Department of Psychology University of Wisconsin-Madison Madison WI United States Center for the Experimental-Philosophical Study of Discrimination Aarhus University Aarhus Denmark Department of Political Science Aarhus University Aarhus Denmark Institute of Psychology University of Tartu Tartu Estonia Department of Mental Health Faculty of Medicine Gulu University Gulu Uganda Department of Psychology Universitas Airlangga East Java Indonesia Department of Psychology University of Colorado Colorado Springs Colorado Springs CO United States Department of Psychology Universidad del Valle Guatemala Guatemala City Guatemala Agroscope Research group Economic Modelling and Policy Analysis Ettenhausen Switzerland Department of Political Science Trinity College Dublin Dublin Ireland Department of Psychology International University of Business Agriculture and Technology Dhaka Bangladesh Department of Philosophy University of Granada Granada Spain Department of Psychology University of Guelph Guelph ON Canada School of Psychology University of Queensland Brisbane QLD Australia Graduate Program in Psychology Universidade Federal do Rio Grande Do Sul RS Porto Alegre Brazil Department of General Psychology University of Padova Padova Italy Faculty of Psychology Universidad El Bosque Bogotá Colombia Ministry of Defence Singapore Sustainability and Education Policy Network Saskatoon SK Canada Escuela Nacional de Estudios Superiores unid

Identifying cues to contagious disease is critical for effectively tracking and defending against interpersonal infection threats. People hold lay beliefs about the types of sensory information most relevant for identifying whether others are sick with transmissible illnesses. Are these beliefs universal, or do they vary along cultural and ecological dimensions? Participants in 58 countries (N = 19,217) judged how effective, and how likely they were to use, cues involving each of the five major sensory modalities in an imagined social interaction during a flu outbreak. Belief patterns were strongly consistent across countries (sight > audition > touch > smell > taste), suggesting a largely universal conceptualization of the role of sensory information for interpersonal respiratory disease detection. Results also support a safe senses hypothesis, with perceivers reporting that they would use senses that function at a distance—and thus reduce pathogen transmission risk—more than would be expected given participants’ beliefs as to the efficacy of these senses for disease detection. Where societal variation did emerge, it was captured by a cohesive set of socio-ecological factors, including human development, latitude, pathogen prevalence, and population density. Together, these findings reveal a shared lens through which contagious respiratory disease is assessed, one that prioritizes minimizing risk to perceivers, and may offer leverage for designing interventions to improve public health. © 2025 Elsevier Inc.

关键词： Behavioral immune system Culture Iterpersonal perception Pathogen threat Sensation Threat detection

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