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A self-assembling nanoplatform for pyroptosis and ferroptosis enhanced cancer photoimmunotherapy

Light(science & Applications) 2025年第1期14卷 153-166页

作者： Zhichao Wang Yuqi Tang Quan Li Institute of Advanced Materials and School of Chemistry and Chemical Engineering Southeast UniversityNanjing211189China Materials Science Graduate Program Kent State UniversityKentOH44242USA

The microenvironment of immunosuppression and low immunogenicity of tumor cells has led to unsatisfactory therapeutic effects of the currently developed *** cell death,such as pyroptosis and ferroptosis,can efficiently boost antitumor ***,the exploration of nanoplatform for dual function inducers and combined immune activators that simultaneously trigger pyroptosis and ferroptosis remains ***,a multifunctional pH-responsive theranostic nanoplatform(M@P)is designed and constructed by self-assembly of aggregation-induced emission photosensitizer MTCN-3 and immunoadjuvant Poly(l:C),which are further encapsulated in amphiphilic *** nanoplatform is found to have the characteristics of cancer cell targeting,pH response,near-infrared fluorescence imaging,and lysosome ***,after targeting lysosomes,M@P can cause lysosome dysfunction through the generation of reactive oxygen species and heat under light irradiation,triggering pyroptosis and ferroptosis of tumor cells,achieving immunogenic cell death,and further enhancing immunotherapy through the combined effect with the immunoadjuvant Poly(I:C).The anti-tumor immunotherapy effect of M@P has been further demonstrated in in vivo antitumor experiment of 4T1 tumor-bearing mouse model with poor *** research would provide an impetus as well as a novel strategy for dual function inducers and combined immune activators enhanced photoimmunotherapy.

关键词： immunotherapy cancer aggregation

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Rheological and stability analysis of cement pastes incorporating silica-based wastes

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Particuology 2024年第6期89卷 144-152页

作者： Julia da Rosa Martins Janaíde Cavalcante Rocha Dachamir Hotza Luciano Senff Graduate Program in Materials Science and Engineering(PPGMAT) Federal University of Santa Catarina(UFSC)Florianópolis88040-900SCBrazil Graduate Program in Civil Engineering(PPGEC) Federal University of Santa Catarina(UFSC)Florianópolis88040-900SCBrazil Graduate Program in Chemical Engineering(POSENQ) Federal University of Santa Catarina(UFSC)Florianópolis88040-900SCBrazil Department of Mobility Engineering Federal University of Santa Catarina(UFSC)Joinville89219-600SCBrazil

This study investigates the influence of waste characteristics,especially zeta potential,on the properties of cement pastes and *** focus is to evaluate the impact of the zeta potential of cement particles and waste materials on the sedimentation speed,rheology,and hardening time of stabilized cement *** Cement II F 40,retarder additive,silica,and fly ash were used in the *** pastes were prepared,and during the stabilization period,their rheological properties and pH were *** zeta potential and sedimentation speed of the cement and waste particles were measured at the pH that the pastes presented during the entire stabilization *** the stabilization period,the pastes were subjected to the hardening time *** zeta potential analyses revealed diverse values for the different powder types,with the cement particles exhibiting a zeta potential of−3.0 mV,the silica particles exhibiting−10.5 mV,and the fly ash particles exhibiting−20.3 *** influence of the high zeta potential modulus was observed on the sedimentation speed,with the solution containing fly ash exhibiting a speed of 40.01μm/s,whereas the solution containing only cement exhibited a speed of 99.38μm/*** the pastes,the results indicate that the presence of fly ash particles with a significantly negative zeta potential led to a 16%reduction in hardening time compared to particles with a lower modulus of zeta *** tests showed that the inclusion of fly ash particles prevented the formation of *** the zeta potential influenced agglomerate formation and hardening time,it was found to have no effect on yield stress or viscosity.

关键词： Wastes Zeta potential Setting time Rheometry

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Recent advances on the systems metabolically engineered Pseudomonas species as versatile biosynthetic platforms for the production of polyhydroxyalkanoates

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Systems Microbiology and Biomanufacturing 2024年第2期4卷 473-499页

作者： Hye Min Song Seo Young Jo Haeyoung Lee Subeen Jeon Dohye Yun Chaerin Kim Jina Son Yu Jung Sohn Jong-Il Choi Si Jae Park Department of Chemical Engineering and Materials Science Graduate Program in System Health Science and EngineeringEwha Womans UniversitySeoul 03760Republic of Korea Department of Biotechnology and Bioengineering Chonnam National UniversityGwangju 61186Republic of Korea

Pseudomonas *** been considered one of the most promising microbial platform strains due to its versatile metabolism,enabling the valorization of waste materials into value-added chemical *** the native producer of polyhydroxyal-kanoates(PHAs),the biodegradable biopolyesters,it has been widely engineered by various metabolic engineering tools for the production of PHAs composed of short-chain-length and medium-chain-length monomers with adjustable composition from diverse carbon sources,ranging from pure sugars to crude oils and fatty *** review discusses the feasibility of Pseudomonas *** the industrial host strain and the recent advances regarding the systems metabolic engineering strategies for PHAs production in Pseudomonas sp.

关键词： Pseudomonas sp. Polyhydroxyalkanoates Systems metabolic engineering Synthetic biology Fermentation

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Flexible refractory castables based on the Al2O3-MgO-TiO2 system

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Ceramics International 2025年第15期51卷 20822-20829页

作者： Reitmann, B. Borges, O.H. Falsetti, L.O.Z. Pagliosa Neto, C. Pandolfelli, V.C. Federal University of São Carlos Graduate Program in Materials Science and Engineering São Carlos Brazil São Carlos Brazil RHI Magnesita Research and Development Center Contagem Brazil

Toughening by in-situ phase formation is highly desired for high-performance refractories, as it enhances their thermomechanical properties (e.g. thermal shock damage resistance). For this purpose, pseudobrookite and intermediary spinels are promising phases due to their thermal expansion mismatch, resulting in self-microcracking. Aiming to develop highly flexible refractory castables, compositions based on the Al2O3-MgO-TiO2 system were formulated with the aid of computational thermodynamics. Of the most promising compositions, five of them were experimentally produced and had their thermomechanical and physical properties assessed by X-ray diffraction, in-situ elastic modulus, thermal shock damage analysis (ΔT = 1000 °C) and scanning electron microscopy. Results pointed out that small titania contents led to a positive effect on microstructure densification, improving the mechanical performance of the refractories and generation of phases that induce microcracking upon cooling, enhancing the thermal shock damage resistance. Nevertheless, an excess of TiO2 led to extensive cracking and cohesion loss in the refractory matrix. © 2025

关键词： Microcracking

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When quantum dots meet blue phase liquid crystal elastomers:visualized full-color and mechanically-switchable circularly polarized luminescence

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Light(science & Applications) 2024年第6期13卷 1210-1220页

作者： Shan Li Yuqi Tang Qingyan Fan Ziyuan Li Xinfang Zhang Jingxia Wang Jinbao Guo Quan Li Key Laboratory of Carbon Fibers and Functional Polymers Ministry of Educationand College of Materials Science and EngineeringBeijing University of Chemical Technology100029BeijingChina Institute of Advanced Materials and School of Chemistry and Chemical Engineering Southeast UniversityNanjing211189China Materials Science Graduate Program Kent State UniversityKentOH44242USA CAS Key Laboratory of Bio-Inspired Materials and Interfacial Sciences Technical Institute of Physics and ChemistryChinese Academy of Sciences100190BeijingChina

Polymer-based circularly polarized luminescence(CPL)materials with the advantage of diversified structure,easy fabrication,high thermal stability,and tunable properties have garnered considerable ***,adequate and precise tuning over CPL in polymer-based materials remains challenging due to the difficulty in regulating chiral ***,visualized full-color CPL is achieved by doping red,green,and blue quantum dots(QDs)into reconfigurable blue phase liquid crystal elastomers(BPLCEs).In contrast to the CPL signal observed in cholesteric liquid crystal elastomers(CLCEs),the chiral 3D cubic superstructure of BPLCEs induces an opposite CPL ***,this effect is entirely independent of photonic bandgaps(PBGs)and results in a high glum value,even without matching between PBGs and the emission bands of ***,the lattice structure of the BPLCEs can be reversibly switched via mechanical stretching force,inducing on-off switching of the CPL signals,and these variations can be further fixed using dynamic disulfide bonds in the ***,the smart polymer-based CPL systems using the BPLCEs for anti-counterfeiting and information encryption have been demonstrated,suggesting the great potential of the BPLCEs-based CPL active materials.

关键词： circular quantum crystal

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Reuse of sodium–doped iridium oxide nanoparticles as a bio–stimulating electrode by a chemical and electrochemical recovery process

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Ceramics International 2024年第4期50卷 6220-6228页

作者： Tso, Kuang-Chih Chen, Chieh-Hsuan Chen, Po-Chun Li, Shao-Sian Chen, Jeng-Lung Ohta, Jun Wu, Pu-Wei Division of Materials Science Graduate School of Science and Technology Nara Institute of Science and Technology Nara630-0192 Japan Graduate Degree Program of Science and Technology of Accelerator Light Source National Yang Ming Chiao Tung University Hsinchu300 Taiwan Department of Materials Science and Engineering National Yang Ming Chiao Tung University Hsinchu300 Taiwan Institute of Materials Science and Engineering National Taipei University of Technology Taipei106 Taiwan National Synchrotron Radiation Research Center Hsinchu300 Taiwan

A sequential chlorination and electrochemical reduction process is demonstrated to convert Na–doped iridium oxide nanoparticles into useful IrIIICl63−(aq) serving as the precursor for the fabrication of bio–stimulating electrode. The Na–doped iridium oxide nanoparticles are treated in 35 wt% hydrochloric acid at 70 °C for 18 h to form IrIVCl62−(aq) with pH of 0.3, so the latter could be readily reduced to IrIIICl63−(aq) at a potentiostatic mode of 0.6 V (vs. SCE). The oxidation state and the nature of complexing ligands for the regenerated IrIIICl63− and IrIVCl62−, as well as commercially available IrIIICl63− are validated by X–ray Absorption Spectroscopy. UV–Vis profiles of regenerated IrIVCl62−(aq) are recorded and the absorbance at 487 nm signal is benchmarked against that of standard IrIVCl62−(aq) to obtain the effective regeneration ratio of 68.6%. X–ray diffraction patterns of Na–doped iridium oxide nanoparticles before and after the annealing treatment indicate the amorphous structure facilitates the chlorination step. The regenerated IrIIICl63− is reused to synthesize Na–doped iridium oxide thin film serving as a bio–stimulating electrode for implantable bio–electronics. The regenerated Na–doped iridium oxide thin film reveals a charge-storage capacity of 0.32 mC/cm2-nm and impressive stability that are comparable to those of fresh Na–doped iridium oxide thin film derived from commercially available IrIIICl63−. © 2023 Elsevier Ltd and Techna Group S.r.l.

关键词： Transition metal oxides

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Low-Temperature Methanolysis of Polycarbonate over Solid Base Sodium Aluminate

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Langmuir 2024年第10期40卷 5338-5347页

作者： Krisbiantoro, Philip Anggo Sato, Miyu Lin, Tzu-Ming Chang, Yu-Chia Peng, Tzu-Yun Wu, Yun-Chih Liao, Weisheng Kamiya, Yuichi Otomo, Ryoichi Wu, Kevin C.-W. Molecular Science and Technology Program Taiwan International Graduate Program Academia Sinica Taipei11529 Taiwan International Graduate Program of Molecular Science and Technology National Taiwan University Taipei10617 Taiwan Department of Chemical Engineering College of Engineering National Taiwan University Taipei10617 Taiwan Graduate School of Environmental Science Hokkaido University Nishi 5 Kita 10 Sapporo060-0810 Japan Faculty of Environmental Earth Science Hokkaido University Nishi 5 Kita 10 Sapporo060-0810 Japan Center of Atomic Initiative for New Materials National Taiwan University Taipei10617 Taiwan Department of Chemical Engineering and Materials Science Yuan Ze University Taoyuan320 Taiwan

Herein, a low-cost and readily available sodium aluminate (NaAlO2) was used as a solid base catalyst for the depolymerization of polycarbonate (PC) via methanolysis in the presence of tetrahydrofuran (THF) as a solvent. NaAlO2 was highly active for the reaction, and the performance was comparable to that of soluble strong base SrO and much higher than those of MgO and CaO. By the reaction over the catalyst, a highly pure and crystalline bisphenol A (BPA) was obtained. Among tested organic solvents, THF was the best in aiding PC methanolysis over NaAlO2 due to the polarity similar to PC according to Hansen solubility parameters (HSPs). At 60 °C, 98.1% PC conversion and 96.8% BPA yield were achieved within just 2 h. NaAlO2 was reusable without any severe catalyst deactivation in at least four runs. The mechanistic study revealed that the reaction proceeded via the methoxide pathway, with THF aiding the dissolution of PC. The reaction over NaAlO2 possessed a low apparent activation energy (Ea) of 75.1 kJ mol-1, which is the lowest ever reported so far for the reaction over solid catalysts. © 2024 The Authors. Published by American Chemical Society.

关键词： Sodium Aluminate

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Bending the Rule: Naphthobisthiadiazole-Based Terpolymers with Both High Solubility and Crystallinity for Organic Photovoltaics

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ACS Applied Polymer materials 2024年第5期6卷 2586-2593页

作者： Chou, Li-Hui Chen, Fengkun Nakano, Kyohei Yamanaka, Kodai Mikie, Tsubasa Saito, Masahiko Liu, Cheng-Liang Tajima, Keisuke Osaka, Itaru Department of Applied Chemistry Graduate School of Engineering Hiroshima University Hiroshima Higashi-Hiroshima739-8527 Japan Department of Chemical and Materials Engineering National Central University Taoyuan32001 Taiwan Saitama Wako351-0198 Japan Applied Chemistry Program Graduate School of Advanced Science and Engineering Hiroshima University Hiroshima Higashi-Hiroshima739-8527 Japan Department of Materials Science and Engineering National Taiwan University Taipei10617 Taiwan

Achieving a good balance between the crystallinity and solubility is of great importance in the design of π-conjugated polymers. Here, we synthesized a series of terpolymers in which small fractions of a planar V-shaped fused ring, triphenyleno[1,2-c:7,8-c′]bis([1,2,5]thiadiazole) (TPTz), are incorporated into the linear-shaped backbone of a highly crystalline polymer based on naphtho[1,2-c:5,6-c′]bis([1,2,5]thiadiazole) (NTz), PNTz4T. Due to the "bending" structure induced by the TPTz unit, the terpolymers had greatly improved solubility by about 5-9 times compared to the linear-shaped PNTz4T. In particular, the terpolymers preserved the crystallinity of PNTz4T to a considerable extent with a higher fraction of face-on oriented domains in films. As a result, the highly solution-processable terpolymers exhibited high photovoltaic performances and slightly outperformed PNTz4T. Our results indicate that the incorporation of a V-shaped unit into a linearly shaped polymer is a good strategy to develop π-conjugated polymers with high solubility and crystallinity. © 2024 American Chemical Society.

关键词： Solubility

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New muonic He atom HFS measurements at J-PARC MUSE

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Interactions 2024年第1期245卷 1-6页

作者： Goto, Yu Fukumura, Seiso Strasser, Patrick Ino, Takashi Iwai, Ryoto Kanda, Sohtaro Kawamura, Shiori Kitaguchi, Masaaki Nishimura, Shoichiro Oku, Takayuki Okudaira, Takuya Shimizu, Hirohiko M. Shimomura, Koichiro Tada, Hiroki Torii, Hiroyuki A. Department of Physics Nagoya University Nagoya Japan Tsukuba Japan Materials and Life Science Division J-PARC Center Tokai Japan Materials Structure Science Program Graduate Institute for Advanced Studies SOKENDAI Tsukuba Japan Kobayashi-Maskawa Institute Nagoya University Nagoya Japan Tokai Japan Graduate School of Science and Engineering Ibaraki University Mito Japan School of Science The University of Tokyo Tokyo Japan

Muonic He (μHe) is a hydrogen-like atom composed of a helium atom with one of its electrons replaced by a negative muon. Measurements of the ground-state hyperfine structure (HFS) interval of the μHe atom is a sensitive tool to test the three-body atomic system, bound-state quantum electrodynamics (QED) theory, and determine fundamental constants of the negative muon magnetic moment and mass. It allows a test of the CPT theorem in muons by comparing these constants with positive muons. Precise measurements of the ground-state HFS interval using a microwave magnetic resonance technique are now in progress at J-PARC by the MuSEUM collaboration. Furthermore, a new experimental approach to recover the muon polarization lost during the muon cascade process is being investigated by repolarizing μHe atoms using a spin-exchange optical pumping (SEOP) technique. The first laser repolarization experiment was recently performed. An overview of the different features of these new μHe atom HFS measurements and the latest results are presented. © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2024.

关键词： Atoms

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Machine learning of organic solvents reveals an extraordinary axis in Hansen space as indicator of spherical precipitation of polymers

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Aggregate 2023年第5期4卷 207-213页

作者： Yuta Ihara Hiroshi Yamagishi Masanobu Naito Yohei Yamamoto Department of Materials Science Faculty of Pure and Applied Sciencesand Tsukuba Research Center for Energy Materials Science(TREMS)University of TsukubaTsukubaJapan Research and Services Division of Materials Data and Integrated System(MaDIS) National Institute for Materials Science(NIMS)TsukubaJapan Program in Materials Science and Engineering Graduate School of Pure and Applied SciencesUniversity of TsukubaTsukubaJapan

Machine learning is an emerging tool in the field of materials chemistry for uncovering a principle from large ***,we focus on the spherical precipitation behavior of polymers and computationally extract a hidden trend that is orthogonal to the availability bias in the chemical *** constructing a dataset,four polymers were precipitated from 416 solvent/nonsolvent combinations,and the morphology of the resulting precipitates were *** dataset was subjected to computational investigations consisting of principal component analysis and machine learning based on random forest model and support vector ***,we eliminated the effect of the availability bias and found a linear combination of Hansen parameters to be the most suitable variable for predicting precipitation *** predicted appropriate solvents are those with low hydrogen bonding capability,low polarity,and small molecular ***,we found that the capability for spherical precipitation is orthogonal to the availability bias and forms an extraordinary axis in Hansen space,which is the origin of the conventional difficulty in identifying the *** extraordinary axis points toward a void region,indicating the potential value of synthesizing novel solvents located therein.

关键词： chemical space computational chemistry machine learning polymers precipitation

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