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Laminated Solid Timber Slab with Transverse Prestressing Using the Strategy of Interleaved Vertical Displacement of Lamellae

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Journal of Civil engineering and Architecture 2024年第4期18卷 186-198页

作者： Bianca Bispo dos Reis Jorge Daniel de Melo Moura Marcos Vinício de Camargo Everaldo Pletz Graduate Program in Architecture and Urbanism Londrina State UniversityJardim Portal de Versalhes 1Londrina 86057-970PRBrazil Department of Civil Engineering Federal Technological University of Paraná(UTFPR)Apucarana 86812-460PRBrazil Retired professor Department of Structural Engineering Londrina State UniversityLondrina 86057-970PRBrazil

This article presents a study on the structural behavior of transversely prestressed laminated timber slabs,focusing on an innovative approach:vertically misaligned *** misalignment,achieved by sliding vertically the wooden lamellae rather than aligning them,enhances the slab’s cross-section moment of inertia,thereby improving load-bearing capacity and *** involved two groups of structural size specimens:one with vertically aligned lamellae(control group)and the other with misaligned lamellae(study group).Results showed the study group exhibited 42%superior stiffness and 10%less load capacity compared to the *** typically occurred individually in the lamellae,particularly in those with defects or lower modulus of elasticity,concentrated in the middle third of the slabs’free span where tensile stresses *** a higher number of failed lamellae,the study group demonstrated promising *** of prestressing bar indicated no damage at all in the thread,suggesting potential for reducing bar *** findings offer crucial insights into applying these slabs in timber construction as well as to any kind of construction.

关键词： Transversal prestressed slabs wooden construction plantation wood flexural testing design methodology

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12.07: Numerical assessment of stayed austenitic steel columns

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ce/papers 2017年第2-3期1卷 3519-3526页

作者： Ribeiro, Danielle M. da S. Vellasco, Pedro C. G. de Araujo, Ricardo R. de Lima, Luciano R. O. da Silva, André T. PGECIV – Civil Engineering Post-Graduate Program State University of Rio de Janeiro – UERJ Brazil Structural Engineering Department State University of Rio de Janeiro – UERJ Brazil Civil Engineering Department Federal Center for Technologic Education Celso Suckow da Fonseca – CEFET/RJ Brazil

The use of prestressed steel stayed columns systems in construction has numerous advantages related to its light weight, load bearing capacity and assembly process flexibility. A practical application of these structural systems could be recently observed in Brazil for the erection of the Rock in Rio III world stage. In this event the use of prestressed stayed carbon steel columns were used for temporary shoring, optimizing the erection sequence. The main stage had a 82 meters span with a 40 m clear height and a 4500 m2 area. Two stayed column were used, both with a 20 m length. Up to the present the majority of investigations of these stayed systems have been focused on carbon steel columns. In view of these facts the present paper aimed to present an investigation of the structural behaviour of columns made with the austenitic stainless steel. Numerical models were developed in the Ansys software, focusing on the structural system load carrying capacity and the optimal level of prestress to be used. The optimal level of prestress to be used was also determined considering the influence of initial imperfections. The results confirmed that the use of prestress in the cables significantly enhance the ultimate loads and ductility capacity of the columns. © Ernst & Sohn Verlag für Architektur und technische Wissenschaften GmbH & Co. KG, Berlin.

关键词： Austenitic stainless steel

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Experimental Assessment of Stainless and Carbon Steel Double-Skin Tubular Stub Columns Filled with Recycled Aggregate Concrete

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ce/papers 2021年第2-4期4卷 764-771页

作者： Castanheira, Deborah S. de Lima, Luciano R. O. Vellasco, Pedro C. G. da S. Cashell, Katherine A. Gardner, Leroy PGECIV - Civil Engineering Post-Graduate Program UERJ – State University of Rio de Janeiro Brazil Department of Civil and Environmental Engineering Imperial College London London United Kingdom Structural Engineering Department UERJ – State University of Rio de Janeiro Brazil Department of Civil and Environmental Engineering Brunel University London United Kingdom

This paper presents an experimental study into the behaviour of concrete filled double skin tubular (CFDST) stub columns. A total of eight axial compression tests were carried out, half of which were filled with conventional concrete and the remainder had recycled aggregate concrete. The columns were circular in cross-section and comprised an austenitic stainless steel outer tube and a carbon steel inner tube, of varying dimensions. Accordingly, hollow ratios of 0.67 and 0.55 were considered. The recycled coarse aggregate was made by crushing test specimens from a previous research project. A replacement ratio of 50% was adopted in these tests. Both the natural coarse aggregates and the recycled aggregates had a maximum diameter of 9.5 mm. During the tests, similar structural behaviour and failure modes were observed between the columns with conventional and recycled aggregate concrete, and the faiure modes were identical. The experimental results are compared with available design procedures and it is ultimately shown that using recycled aggregate concrete rather than regular concrete in CFDST stub columns does not have a significant effect on the performance. © 2021 Ernst & Sohn Verlag für Architektur und technische Wissenschaften GmbH & Co. KG, Berlin.

关键词： Compression testing

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NUMERICAL EVALUATION OF DUPLEX STAINLESS STEEL STAYED COLUMNS

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ce/papers 2019年第5-6期3卷 252-261页

作者： Ribeiro, Danielle M. da S. Vellasco, Pedro C. G. de Lima, Luciano R. O. de Araújo, Ricardo R. da Silva, André T. PGECIV – Civil Engineering Graduate Program State University of Rio de Janeiro – UERJ Brazil Structural Engineering Department State University of Rio de Janeiro – UERJ Brazil Civil Eng. Department Tecn. Education Federal Centre Celso Suckow da Fonseca – CEFET/RJ Brazil

The use of prestressed stayed steel column systems in construction has numerous advantages related to its high strength and assembly flexibility. The present work aims to present an investigation of the structural behaviour of duplex stainless steel columns through a numerical modelling, using the finite element method, through the ANSYS program. The results confirmed that the use of cable prestress significantly increases the ultimate loads and ductility of the system, indicating the potential of these efficient and promising solutions. This was mainly due to their considerable resistance gain and numerous advantages in replacing carbon by stainless steel. © 2020 Ernst & Sohn Verlag für Architektur und technische Wissenschaften GmbH & Co. KG, Berlin.

关键词： Stainless steel

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Development and Application of a Genetic Algorithm for Selecting High Entropy Alloys with Good Combinations of Mechanical Properties

SSRN

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SSRN 2024年

作者： Stoco, Caroline Binde Cassar, Daniel Roberto Kaufman, Michael Clarke, Amy Coury, Francisco Gil Federal University of São Carlos Graduate Program in Materials Science and Engineering SP São Carlos Brazil SP Campinas Brazil Center for Advanced Non-Ferrous Structural Alloys George S. Ansell Department of Metallurgical and Materials Engineering Colorado School of Mines GoldenCO United States

A genetic algorithm was developed to search for high entropy alloys (HEAs) with good combinations of mechanical properties. The algorithm was designed to solve a multi-objective problem of finding single-phase face-centered cubic HEAs with high Hall-Petch constants and high critical resolved shear stresses. The goal was to obtain an alloy with good ductility and strength. The most promising alloy suggested by the genetic algorithm was an unconventional composition (Co32.73Cu15.11Fe0.72Hf0.72Mn35.97Mo3.96Ni10.43Sn0.36);this alloy was experimentally produced and characterized. An advantage of the proposed method is the possibility of more systematically identifying and exploring new compositions in the complex composition space characteristic of these multicomponent alloys. However, the thermodynamic parameters used for this selection process exhibited limitations, which were further explored in the present study, as evidenced by the fact that the microstructure of the selected alloy was not single-phase. © 2024, The Authors. All rights reserved.

关键词： Phase equilibria

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A STUDY ON DYNAMIC RESPONSE DISPLACEMENT MEASURING METHODS FOR BUILDING UNDER EARTHQUAKE USING SATELLITE TECHNOLOGY WITH TWO MOVABLE VIBRATION TABLES

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AIJ Journal of Technology and Design 2024年第74期30卷 65-70页

作者： Hashimoto, Akihiro Mukai, Tomohisa Tajima, Kazuyuki Nakamura, Akihiro Ariki, Katsuyoshi Kinugasa, Hideyuki Dept. of Architecture Graduate School of Science and Technology Tokyo Univ. of Science Japan Building Dept. National Institute for Land and Infrastructure Management Program Management Division Ground Facilities Dept. The Japan Aerospace Exploration Agency Dept. of Structural Engineering Building Research Institute Dept. of Structural Engineering Building Research Institute Urban Renaissance Agency Japan Dept. of Architecture Faculty of Science and Technology Tokyo Univ. of Science Japan

In recent years, research has been conducted to establish a method for quickly and appropriately determining damage to buildings during an earthquake using sensors, and it’s useful to appropriately evaluate the maximum and residual displacement during an earthquake. The purpose of this study is to propose a disaster assessment method using a satellite positioning system that directly measures the response displacement of a building from satellite positioning information. In this paper, the positioning accuracy is verified when calculating the relative displacement using two movable vibration tables that assume the top floor of a building and the ground surface under earthquake. © 2024 Architectural Institute of Japan. All rights reserved.

关键词： Earthquakes

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Mapping the interaction surface between CaVβ and actin and its role in calcium channel clearance

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Nature Communications 2025年第1期16卷 1-21页

作者： Castilla, Francisco Lugo, Victor Miranda-Laferte, Erick Jordan, Nadine Huesgen, Pitter F. Santiago-Schübel, Beatrix Alfonso-Prieto, Mercedes Hidalgo, Patricia Institute of Biological Information Processing (IBI-1)—Molecular and Cellular Physiology Forschungszentrum Jülich Jülich Germany Graduate Program Faculty of Mathematics and Natural Sciences Heinrich-Heine University Düsseldorf Germany Biologics Analytical Research and Development AbbVie Deutschland GmbH & Co. KG Ludwigshafen Germany Central Institute of Engineering Electronics and Analytics (ZEA-3) Forschungszentrum Jülich Jülich Germany Institute of Biology II University of Freiburg Freiburg Germany Institute of Biological Information Processing (IBI-7)—Structural Biochemistry Forschungszentrum Jülich Jülich Germany Institute of Neuroscience and Medicine (INM-9)—Computational Biomedicine Forschungszentrum Jülich Jülich Germany Cécile and Vogt Institute for Brain Research Medical Faculty Heinrich-Heine University Düsseldorf Germany Institute of Biochemistry Heinrich-Heine University Düsseldorf Germany

Defective ion channel turnover and clearance of damaged proteins are associated with aging and neurodegeneration. The L-type CaV1.2 voltage-gated calcium channel mediates depolarization-induced calcium signals in heart and brain. Here, we determined the interaction surface between actin and two calcium channel subunits, CaVβ2 and CaVβ4, using cross-linking mass spectrometry and protein-protein docking, and uncovered a role in replenishing conduction-defective CaV1.2 channels. Computational and in vitro mutagenesis identified hotspots in CaVβ that decreased the affinity for actin but not for CaV1.2. When coexpressed with CaV1.2, none of the tested actin-association-deficient CaVβ mutants altered the single-channel properties or the total number of channels at the cell surface. However, coexpression with the CaVβ2 hotspot mutant downregulated current amplitudes, and with a concomitant reduction in the number of functionally available channels, indicating that current inhibition resulted from a build-up of conduction silent channels. Our findings established CaVβ2–actin interaction as a key player for clearing the plasma membrane of corrupted CaV1.2 proteins to ensure the maintenance of a functional pool of channels and proper calcium signal transduction. The CaVβ–actin molecular model introduces a potentially druggable protein-protein interface to intervene CaV-mediated signaling processes. © The Author(s) 2025.

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Development of a Deep Learning Model for Binding Affinity Prediction and Fragment-based de novo Drug Design

Development of a Deep Learning Model for Binding Affinity Pr...

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中国生物化学与分子生物学会第十二届全国会员代表大会暨2018年全国学术会议

作者： Shiwei Wang Jianfeng Pei Luhua Lai PTN Joint Graduate Program Academy for Advanced Interdisciplinary StudiesPeking University Center for Quantitative Biology Academy for Advanced Interdisciplinary StudiesPeking University BNLMS State Key Laboratory for Structural Chemistry of Unstable and Stable Speciesand Peking-Tsinghua Center for Life Sciences at College of Chemistry and Molecular EngineeringPeking University

The traditional drug design and discovery methods were time-consuming and expensive,which largely reduced the efficiency of drug design ***-based de novo drug design was applied to accelerate the procedure of drug *** a complementary of high-throughput screening technology,de novo drug design method is confronted with a virtually infinite search *** drug-like molecules can be discovered by exploring the chemical space with specific combinational search strategies,which provides a new approach to find novel ***,challenges including combinatorial explosion,scoring function and so on hinder the development and application of de novo drug *** this work,we hope to construct a reinforcement-learning model by combing Monto Carlo Tree Search method and deep neural network to solve the combinatorial explosion *** order to achieve our goals,we updated our Pocket program to extract more accurate pharmacophore models,which can help to extract features of 3 D structure information of protein-ligand ***,we developed a new scoring function to predict binding affinity of protein-ligand complex based on the 3 D structure *** further improving and optimizing,the new scoring function could be applied to binding affinity prediction and will be integrated to our fragment-based de novo drug design method.

关键词： scoring function Representation of binding pocket de novo drug design Reinforcement learning

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12.15: structural performance of stainless lap bolted joints

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ce/papers 2017年第2-3期1卷

作者： Raphael Freire Pedro Colmar Gonçalves da Silva Vellasco André Tenchini da Silva Luciano Rodrigues Ornelas de Lima PGECIV – Civil Engineering Post-Graduate Program State of Rio de Janeiro – UERJ Structural Engineering Department State University of Rio de Janeiro – UERJ

The stainless steel employed in the structural elements present high corrosion resistance, durability, fire resistance and high aesthetic value compared to those constructed using carbon steel. In contrast, the stainless steel structures design is made following the requirements based on the carbon steel analogies. In fact, the structural performance of stainless steel is complex and dissimilar where some stainless grades presenting nonlinear tension versus strain curves without a defined yield plateau and large strain hardening. These properties influence on structural performance of the lap bolted joints. The Eurocode 3 pt. 1.4, one of the most adopted design codes, recommends two structural design criteria for the stainless steel elements under tension: ultimate resistance of the net cross-section at holes or plastic resistance of the gross cross-section. The present work aimed to investigate the structural response of lap bolted joints made of three stainless steel grades: austenitic, ferritic and duplex. Nonlinear numerical analyses has been carried out using ABAQUS 6.14 program where the response have shown a good agreement in terms of the maximum loads and failure modes when compared to the performed experiments. The results indicated a conservative level of safety from Eurocode 3 pt. 1.4 code provisions in comparison to the experimental results.

关键词： stainless steel lap bolted joint experimental analysis numerical finite element simulations

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SHIP DESIGN AND THE NAVY LABORATORY

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NAVAL ENGINEERS JOURNAL 1981年第2期93卷 33-46页

作者： ELLSWORTH, WM CLARK, DJ Mr. William M. Ellsworth:is graduate of the State University of Iowa from which he received B.S. and M.S. degrees in Engineering majoring in Fluid Mechanics. Upon graduation in 1948 he joined the Staff of the David Taylor Model Basin (DTMB) and during the following ten years held various positions in the Hydromechanics Laboratory. In 1958 he left his position as Head of the Towing Problems Branch and joined Cleveland Pneumatic Industries which later became Pneumo Dynamics Corporation (PDC). He was General Manager of PDC's Systems Engineering Division and in 1961 became a corporate Vice President. In 1964 he returned to DTMB where he became the Technical Manager of the Hydrofoil Development Program Office. In October 1969 he was appointed to his present position of Associate Technical Director for Systems Development and Head Systems Development Department David W. Taylor Naval Ship Research and Development Center. He is a licensed Professional Engineer in the state of Maryland an Honorary Life Member of ASNE and a Fellow of ASME. He also has been the author of a number of papers and reports in the field of Naval Engineering and has served as a member of the ASNE Council from 1972 to 1974 was a member of the ASNE Flagship Section Council (1977-80) and is currently a member of the ASNE Honors and Awards Committee. He became a member of ASNE in 1960 and received his Honorary Life Membership when he was awarded the ASNE Gold Medal for 1973 at ASNE Day 1974. Dennis J. Clark:received his Bachelor's degree in Civil Engineering from City College of New York in 1963. Upon graduating he joined DTMB's Structural Mechanics Laboratory where he worked on a number of full-scale trials of surface ships evaluating the structural integrity of icebreakers sonar domes and Hydrofoils. He eventually was responsible for the entire structural research program in support of the Hydrofoil Advanced Development Office and in 1971 joined the Hydrofoil Program Office as the Manager of Systems Integration. In that capacity he

In today's environment of rapidly escalating costs, increasing technological complexity, and growing threat, we must actively seek ways to improve our effectiveness in applying limited resources to the design of Navy ships. One important aspect of this process involves the development and application of new technology to ship design. An exhaustive treatment of this subject is clearly beyond the scope of a single technical paper. It is the Authors' objective, however, to acquaint the reader with the nature and role of the Navy's Laboratory Community in general and DTNSRDC in particular; to examine some recent initiatives taken at DTNSRDC and some key issues; and, hopefully, to contribute in some small way to the building of a stronger constructive partnership between ship development and design activities. The view is that from the perspective of a Navy Laboratory and pertains to the design of the ship itself as opposed to the weapons system.

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