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ESTABLISHING THE FUNDAMENTALS OF A SURFACE SHIP SURVIVABILITY DESIGN DISCIPLINE

NAVAL ENGINEERS JOURNAL 1994年第1期106卷 71-74页

作者： BALL, RE CALVANO, CN Robert E. Ball:attended Northwestern University where he received BS and MS degrees in civil engineering in 1958 and 1959 and a Ph.D. in structural mechanics in 1962. From 1962 to 1967 he worked in the aerospace industry. In 1967 he joined the faculty of the Naval Postgraduate School (NPS) Monterey Ca. and is currently a professor in the department of aeronautics and astronautics. In 1976 Dr. Ball began developing an educational program in aircraft combat survivability at NPS. Approximately 3500 Navy Marine Army and Air Force officers DoD civilians and civilians from the US aircraft industry attended his NPS graduate level and short courses since 1977. He has conducted short courses for NATO and the governments of Canada and Greece. He has also developed similar graduate level courses at NPS in air defense lethality and surface ship combat survivability. He has conducted an extensive research program in survivability and lethality at NPS directing over 110 theses and in 1985 his 400 page textbook The Fundamentals of Aircraft Combat Survivability Analysis and Designwas published by AIAA. He is a Fellow of AIAA. Charles N. Calvano:is a 1963 graduate of the U.S. Naval Academy and a 1970 graduate of MIT with an MS in ocean engineering and a naval engineer's degree. His active duty Navy career spanned twenty-eight years culminating in assignments in the Naval Sea Systems Command as the director of the ship design group and as the director for ship concepts and technology. He joined the faculty of the Naval Postgraduate School in October 1991 and is developing and teaching the total ship systems engineering curriculum discussed in this paper. He is a member of ASNE and of the Society of Naval Architects and Marine Engineers.

This paper describes a conceptual structure of ship survivability definitions and concepts and deals with the need to incorporate a total-ship approach to surface ship combat survivability as part of the philosophy used to guide a ship's design. Included are: A discussion of the increasing emphasis placed on ship survivability during the ship system development process. Definitions of the different aspects of ship survivability, in order to suggest a coordinated and coherent understanding of their relationships. A discussion of the value of making survivability considerations an integral part of the ship design philosophy, to ensure a requirements-based systems approach to all of the ship's required attributes, including survivability.

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High Resolution Imaging of Virus in Liquid Droplets: The Application of Cryo-TEM Methodology to Improve Liquid-phase TEM Imaging of Biological Materials

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Microscopy and Microanalysis 2021年第S2期27卷 19-20页

作者： Madeline J. Dukes GM Jonaid William J. Dearnaley Michael A. Casasanta Deborah F. Kelly Protochips Inc.Morrisville NC USA. Bioinformatics and Genomics Graduate Program Huck Institutes of the Life Sciences Pennsylvania State University University Park PA USA. Department of Biomedical Engineering Pennsylvania State University University Park PA USA. Materials Research Institute Pennsylvania State University University Park PA USA. Center for Structural Oncology Pennsylvania State University University Park PA16802 USA.

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Analytical model of retrofitted reinforced concrete beam column joints after experiencing severe damage from earthquake load simulation using SAP2000

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IOP Conference Series: Materials Science and engineering 2019年第1期508卷

作者： N Gosal I Imran M Riyansyah Post Graduate Program of Faculty of Civil Engineering Bandung Institute of Technology 40132 Bandung Indonesia Structural Engineering Department Faculty of Civil Engineering Bandung Institute of Technology 40132 Bandung Indonesia

An earthquake resistant structure should be able to perform as expected when it's struck by an earthquake such as it may experience slight damage and should be able to be repaired to its original state when struck by a design level earthquake. However, there are still debates whether reparation should also be viable when structures are experiencing severe damage. There are still a little to no studies about repairing severely damaged structures, therefore a study was made to see how severely damaged structures behaved after being repaired. Two beam column joints are used as specimens, which were severely damaged by an earthquake simulation before getting repaired. Both their initial and repaired condition are then modeled analytically using SAP2000. Their behaviors such as plastic hinges, joint's shear deformation, bond slip, and rebars' residual strain and stress due to previous loading are also implemented to the model. Although the lateral strength of the specimens are similar to their analytical model, the other behavior, especially their stiffness is not similar, therefore needing another parameter implemented in the model.

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FLAMMABILITY AND TOXICITY OF COMPOSITE-MATERIALS FOR MARINE VEHICLES

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NAVAL ENGINEERS JOURNAL 1990年第5期102卷 45-54页

作者： SEVART, JL GRIFFIN, OH GURDAL, Z WARNER, GA Jeffrey L. Sevart:is a native of Kansas and a 1985 graduate of Kansas State University with a B.S. in mechanical engineering (magna cum laude). After working as a stress analysis engineer at Boeing Military Airplane Company in Wichita Kans. he attended Virginia Polytechnic Institute and State University and received an M.S. in engineering mechanics in February 1988. He currently resides in Akron Ohio working as a research engineer in tire composites research at The Goodyear Tire and Rubber Company. O. Hayden Griffin Jr.:received his B.S. and M.S. in mechanical engineering from Texas Tech University in 1970 and 1971 respectively. He received his Ph.D. in engineering mechanics from Virginia Polytechnic Institute and State University in 1980. Prior to joining the faculty of Virginia Polytechnic Institute and State University as associate professor of engineering science and mechanics in September 1985 he was employed at the U.S. Naval Surface Warfare Center (Dahlgren Virginia) BF Goodrich Tire Group (Akron Ohio) the Bendix Advanced Technology Center (Columbia Maryland) and the Johns Hopkins University Applied Physics Laboratory (Laurel Maryland). He is currently an associate director of the Virginia Institute for Material Systems. He is a registered professional engineer in Virginia and is a member of the American Society of Mechanical Engineers and the American Society for Composites. Zafer Gürdal:received his M.S. in mechanical and aerospace engineering from Illinois Institute of Technology in 1981 and his Ph.D. in aerospace engineering from Virginia Polytechnic Institute and State University in 1985. He worked as a research associate in the Aerospace and Ocean Engineering Department at Virginia Tech before joining the Engineering Science and Mechanics Department as an assistant professor in September 1985. Professor Gürdal's research interests include: composite structures failure mechanics of composites structural optimization and damage tolerant design. He is a member of the American Institute

Characteristics of both thermoplastic and thermoset composite materials as they pertain to marine vehicle applications are discussed. Comparison of various material selection factors such as strength, damage and moisture resistance, and flammability and toxicity as well as cost and availability of thermoset and thermoplastic composite materials are presented. Methods for testing and reducing the flammability and toxicity are discussed. Many commercially available composite systems are reported to provide favorable characteristics for marine applications. Although there seems to be a need for improved production technology for thermoplastics, they present potential advantages in physical properties over thermoset composites.

关键词： Composite Materials

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Development of label-free triboelectric nanosensors as screening platforms for anti-tumor drugs

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Nano Energy 2024年 125卷

作者： Cheng, Yu-Ying Ganguly, Anindita Cheng, Yi-Yun Ortiz, Christopher Llynard D. Pal, Arnab Shah, Pramod Kaswan, Kuldeep Yang, Lee-Wei Lin, Zong-Hong Department of Biomedical Engineering National Taiwan University Taipei10617 Taiwan Institute of Biomedical Engineering National Tsing Hua University Hsinchu30013 Taiwan Internet of Senses Research Center National Tsing Hua University Hsinchu30013 Taiwan Praexisio Taiwan Inc. New Taipei221425 Taiwan Institute of Bioinformatics and Structural Biology National Tsing Hua University Hsinchu300044 Taiwan Chemical Biology and Molecular Biophysics Program Taiwan International Graduate Program Institute of Biological Chemistry Academia Sinica Taipei115 Taiwan Department of Chemistry National Tsing Hua University Hsinchu300044 Taiwan International Intercollegiate PhD Program National Tsing Hua University Hsinchu300044 Taiwan Department of Power Mechanical Engineering National Tsing Hua University Hsinchu300044 Taiwan Biomedical Artificial Intelligence PhD Program National Tsing Hua University Hsinchu300044 Taiwan Physics Division National Center for Theoretical Sciences Taipei Taiwan

This study introduces a general label-free drug screening platform with potential to support high-throughput drug screening for any protein target. Its innovation lies in quantifying the affinity of molecule-molecule interactions via voltage output variation, which achieves unprecedented selectivity and sensitivity. It combines computational analysis complemented by experimental substantiation with a solid-liquid triboelectric nanosensor. Owing to its high binding affinity, FKBP-rapamycin is used as a model system to demonstrate the platform's sensitivity. Subsequently, the research is extended to study drug interactions with an oncogenic protein ATG4B. The findings unveil the binding of S130 and Tioconazole to ATG4B, a critical cysteine protease involved in autophagy, while revealing that Dexamethasone does not bind ATG4B. This binding exerts a specific inhibitory effect on autophagic flux and triggers cancer cell apoptosis. The results support the previously verified inhibitory effects of these drugs and the effectiveness of a newly developed self-powered drug screening platform, leveraging the principles of solid-liquid contact electrification. This approach adeptly confronts enduring challenges in traditional drug development methods where biochemical assays need to be designed for each individual protein target or only time-consuming and concentration-demanding molecular interaction measurements were made available. © 2024 Elsevier Ltd

关键词： Nanosensors

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RELIABILITY-BASED FATIGUE DESIGN FOR SHIP STRUCTURES

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NAVAL ENGINEERS JOURNAL 1987年第3期99卷 135-149页

作者： WHITE, GJ AYYUB, BM Gregory J. White: LCdr. USNR-R is an assistant professor of naval architecture at the U.S. Naval Academy. He received a B. S. degree in engineering mechanics from Vanderbilt University in 1975 an M. E. degree in naval architecture from the University of California Berkeley in 1981 and a Ph.D. from the University of Maryland in 1986. Dr. White served on active duty with the U.S. Navy from 1975 to 1979 first as the damage control assistant aboard the USS Reasoner (FF-1063) and then as the commissioning CIC officer aboard the USS Merrill (DD-976). After leaving active duty and while attending graduate school he worked at Mare Island Naval Shipyard in the scientific section (Code 250.1). Upon completion of graduate school he then worked for Exxon International Company as a research engineer in the R & D division of the tanker department. A lieutenant commander in the Ready Reserve Dr. White drills with the repair department of a submarine tender reserve unit and recently completed the reserve engineering duty officer qualification program. A member of ASNE since 1983 Dr. White is also a member of SNAME and the U.S. Naval Institute Dr. White received the “Jimmie” Hamilton Award for 1985. Bilal M. Ayyub:is currently an assistant professor of civil engineering at the University of Maryland. He received his B. S. degree in civil engineering from the University of Kuwait in 1980. He completed both his M. S. (1981) and Ph.D. (1983) in civil engineering at the Georgia Institute of Technology. While there he was awarded the Kuwait Foundation for the Advancement of Science Fellowship. Dr. Ayyub has extensive background in risk-based analysis and design simulation pre-stressed composite steel girders and construction engineering. He is engaged in research work involving structural reliability bridges marine structures mathematical modelling using the theories of probability statistics and fuzzy sets. His research work is sponsored by the National Transportation Safety Board the University of Maryland the Natio

In the continuing effort to apply reliability methods to marine structures, the next logical step is to include these techniques in the design process. The advantage of doing this would be the ability to design more efficient structures with some measure of certainty of the reliability level involved. The particular application in ship structural design which would benefit the most from using reliability methods is the design against fatigue failure. In this paper, some of the reliability-based methods currently being used (or proposed for use) in the design of structures against fatigue are examined. Each is evaluated as to its suitability for use in the structural design of ships. In addition, the authors propose a new reliability-based fatigue design format which is based on their recently introduced Reliability-Conditioned (RC) design method and the Load and Resistance Factor Design (LRFD) code format. This approach is hoped to provide the design engineer with an easy to understand and use tool based on the LRFD format. The RC method will enable him to quickly and accurately design the components of a ship's structure such that a desired level of safety against fatigue is achieved. Each of the methods discussed is used to solve a practical example. The results of that example and several others are used to discuss the relative merits of each method.

关键词： SHIPS

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THE structural SYNTHESIS DESIGN program - ITS IMPACT ON THE FLEET

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NAVAL ENGINEERS JOURNAL 1983年第3期95卷 87-99页

作者： WIERNICKI, CJ GOODING, TG NAPPI, NS Mr. Christopher J. Wiernicki:graduated from Vanderbilt University in 1980 with a B.E. degree in Structural Engineering. Upon graduation he began his professional career at the David Taylor Naval Ship Research and Development Center. As a structural engineer in the Surface Ship Structures Division Mr. Wiernicki was responsible for developing improved methods and procedures for designing and evaluating structural systems for surf ace combatants. Specific projects included design for producibility development and evaluation of automated ship structural design methods and participation in the structural design of the CG 49 Cruiser and the current DDG 51 Destroyer. In 1982 Mr. Wiernicki received his M.S. degree in Ocean Engineering from George Washington University. Mr. Wiernicki is a recipient of the SNAME 1982-82 Graduate Scholarship and is currently doing post graduate work in Naval Architecture at Massachusetts Institute of Technology he is a member of ASNE SNAME ASCE and Chi Epsilon. Mr. Thomas G. Gooding:graduated in 1975 from the University of Michigan with B.S. degrees in Oceanography and Naval Architecture. After graduation he began his professional career at the Naval Ship Engineering Center (NA VSEC) as a structural engineer. From 1975 till 1978 Mr. Gooding worked in the area of ship dry docking and was the structural task leader on the complex overhaul ofUSS Long Beach (CGN-9). Mr. Gooding returned to the University of Michigan to receive a M.S. in Naval Architecture in 1979. Currently Mr. Gooding is the structural task leader on the DDGX/DDG 51 program at the Naval Sea Systems Command (NAVSEA). Mr. Gooding is a member of SNAME and the Naval Institute. Mr. Natale S. Nappi:graduated from City College of New York in 1954 with a Bachelor of Civil Engineering and received his M.S. in Civil Engineering from Polytechnic Institute of Brooklyn in 1959. He began his professional career in 1964 at the New York Naval Shipyard as a Naval Architect (Structure) performing detail structural design and fabrication s

The structural design of a ship's section is a complicated, repetitive and time consuming task. With the advent of new technology, high speed computers have enabled the ship designer to accomplish in a matter of seconds what would formerly take days to accomplish by hand. The structural Synthesis Design program (SSDP) is a N avy developed computer-aided design tool which is used to design (or to analyze) the longitudinal scantlings for a variety of ship cross sections, consisting of any practical combinations of decks, platforms, bulkheads and materials, i.e., various steel and aluminum alloys. The final hull section design will have the lowest practical weight for the chosen geometric configuration, structural arrangements, and imposed loadings. The scantling developed by the program will satisfy all U.S. N avy ship structural design criteria. An explanation of the objective and design elements of N avy ship structures is included. The rationale behind the SSDP design philosophy is developed along with the significant program capabilities. In an attempt to highlight the influence of automated design procedures on the current naval ship design process, the effect of the SSDP on the DDG 51 destroyer structural development is addressed.

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Reliability analysis of transverse stability of surface ships

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NAVAL ENGINEERS JOURNAL 1997年第3期109卷 129-140页

作者： Atua, K Ayyub, BM Khaled l. Atua:is a graduate student at the Reliability Engi-neering Program at the University of Maryland at College Park. He completed his B.S. degree in naval architecture and marine engineering in 1988 and completed his M.S. degree in naval architecture and marine engineering in 1992 at Alexandtia University. He is also a visiting scholar in the Civil Engineering Department at the University ofMaryland at Colkge Park. He is conducting research with Dc Bilal M. Ayyub in the area of develupment of reliability-based design of ship structures and systems. He is a member ofASNE and SNAME. He has authored or coauthored several papers and reports. Bilal M. Ayyub: Ph.D. RE. is aprofssor of civil engineer-ing at the University of Maryland at College Park. He is also a researcher and consultant in the areas of structural engineering inspection methods and practices reliability and risk analysis. Dc Ayyub completed his B.S. degree in civil engineering in 1980 and completed both his M.S. (1981) and Ph.D. (1983) degrees in civil engineering at the Georgia Institute of Echnol-OD. Dc Ayyub has an extensive background in uncertainty modeling and analysis risk-based analysis and design simula-ion and marine structural reliability. He is engaged in research work involving structural reliability marine structures uncer-tainty modeling and analysis and mathematical modeling using the theories of probability statistics and fuzzy sets. He has completed several research projects that were funded by the National Science Foundation the U S. Coast Guard the U.S. Navy the U.S. Department of Defense the U.S. Army crops of Engineers the Maryland State Highway Administration the American Society ofMechanica1 Engineers and several engi-neering companies. Dc Ayyub served the engineering communio in various capacities through societies that include ASNE ASCE ASME SNAME IEEE-CS and NMIPS. He is a member ofthe ASME Research Committee of Risk Ethnology and the ASME Committee on Human Factors. Currently he is the chai

An introduction to a rational development of transverse stability criteria for surface ships is presented in this paper. The development is based on a probabilistic analysis of the uncertainties associated with the design parameters involved in determining the transverse stability. Reliability methods are used for assessing and determining transverse stability of ships. These reliability methods address the uncertainties associated with the basic design variables that are involved in stability assessment and design. The sources of uncertainty in stability variables are presented, uncertainties associated with these basic random variables are summarized, different reliability assessment methods are described, a case study that shows the computation procedure using some of these methods is discussed for illustration purposes, and finally, conclusions and recommendations for further work in this area are presented.

关键词： Naval vessels

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Double affinity ligands modified graphene enabled orientation-controllable cryo-EM sample preparation

Double affinity ligands modified graphene enabled orientatio...

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第七届全国冷冻电子显微学与结构生物学专题研讨会

作者：程航 Liming Zheng Nan Liu Jie Xu Congyuan Huang Ye Lu Hailin Peng Yanan Chen Hong-Wei Wang Ministry of Education Key Laboratory of Protein Sciences Beijing Advanced Innovation Center for Structural BiologySchool of Life SciencesTsinghua University Tsinghua-Peking Joint Center for Life Sciences Tsinghua University Center for Nanochemistry Beijing Science and Engineering Center for NanocarbonsBeijing National Laboratory for Molecular SciencesCollege of Chemistry and Molecular EngineeringPeking University Joint Graduate Program of Peking-Tsinghua-NIBS School of Life SciencesTsinghua University Academy for Advanced Interdisciplinary Studies Peking University School of Materials Science and Engineering Tianjin University Beijing Frontier Research Center for Biological Structures Tsinghua University

With the development of both hardwares and softwares of cryo-electron microscopy (cryo-EM),high- resolution structures of macromolecules have been increasingly ***,the robustness and generality of this technique are severely challenged by the air-water interface and preferred orientation issues during specimen preparation,which practically take plenty of efforts to overcome,especially for those hard *** we reported double-modified graphene (DMG) as the supporting material in cryo-EM sample preparation by covalently modified graphene membrane with two different affinity ligands,

关键词： DMG Double affinity ligands modified graphene enabled orientation-controllable cryo-EM sample preparation

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Corrigendum to “Experimental and numerical investigation of SHS truss T-joints reinforced with sidewall plates” [Thin-Walled Struct. 145 (2019) 1–16]

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Thin-Walled Structures 2020年 146卷

作者： N.V. Gomes L.R.O. de Lima P.C.G. da S Vellasco A.T. da Silva M.C. Rodrigues L.F. Costa-Neves Structural Engineering Department UERJ – State University of Rio de Janeiro Brazil PGECIV - Civil Engineering Post-Graduate Program UERJ – State University of Rio de Janeiro Brazil INESCC Civil Engineering Department - University of Coimbra Portugal

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