检索结果-内蒙古大学图书馆

structural ANALYSIS AND DESIGN OF A CATAMARAN CROSS‐STRUCTURE BY THE FINITE ELEMENT METHOD

Naval Engineers Journal 1973年第1期85卷 33-42页

作者： MANSOUR, DR.A. FENTON, LCDR. PAUL H. Dr. A. Mansour an Associate Professor in the Department of Ocean Engineering at Massachusetts Institute of Technology received his Bachelor of Science degree in Mechanical Engineering from the University of Cairo in 1958 and his M.E. and Ph.D. degrees in Naval Architecture and Marine Engineering from the University of California at Berkeley in 1962 and 1966 respectively. He has had field experience and design responsibilities for about six years in the Suez Canal Authority John J. McMullen Associates Inc. and M. Rosenblatt and Son Inc. and has been with the Massachusetts Institute of Technology for the past four years. During this period he contributed several technical papers and reports in the areas of structural mechanics sea loads finite element analysis of marine structures and probabilistic structural mechanics. He has been a consultant for several companies and organizations is a member of Sigma Xi and SNAME currently serving as a member of the latter's Stress Analysis and Strength of Structural Elements Panel. USN Lieutenant Commander Paul H. Fenton USN a 1964 graduate of the U.S. Naval Academy recently completed a graduate education program at M.I.T. in the field of Naval Construction and Engineering earning two degrees: Ocean Engineer and Master of Science in Naval Architecture and Marine Engineering. He is presently assigned to the Charleston Naval Shipyard Charleston South Carolina and has had previous duty in the U.S.S. STICKELL (DD 888) and with the Naval Support Activity Saigon.

One of the problems encountered during the design of the ASR‐21 Catamaran is the determination of the effectiveness of the cross‐structure deck plating. In this paper, this problem is examined using the Finite Element Method. The behavior of a multicell box girder representing a catamaran cross‐structure is studied. Because of the relatively low length‐to‐breadth ratio of a typical catamaran cross‐structure, the deck plating effectiveness is found to be rather small. Parametric studies are performed, and curves of the effectiveness as a function of the relevant geometric and loading parameters are presented. These curves may be helpful in the early stages of new designs. © 1973 by the American Society of Naval Engineers

关键词：

来源：评论

学校读者我要写书评

暂无评论

Mechanistic Insights into CLNS1A-Mediated Chemoresistance and Tumor Progression in Non-small Cell Lung Cancer

引用

Cancer letters 2025年 217783页

作者： Tong-You Wade Wei Jiun-Yi Hsia Tsung-Ying Yang Yu-Xu Huang Guo-Zhi Wang Yi-Chung Liu Yi-Wun Wang Fangzhou He Jo-Mei Maureen Chen Guo-Jun Zhao Ping-Chiang Lyu Li-Jen Su Shao-Chih Chiu Chang-Tze Ricky Yu Department of Applied Chemistry National Chi Nan University Nantou Taiwan Division of Cardiology Department of Medicine University of California San Diego La Jolla California USA. Electronic address: t1wei@health.ucsd.edu. Division of Thoracic Surgery Chung Shan Medical University Hospital Taichung Taiwan School of Medicine Chung Shan Medical University Taichung Taiwan. Department of Chest Medicine Taichung Veterans General Hospital Taichung Taiwan Doctoral Program in Translational Medicine National Chung Hsing University Taichung Taiwan. Department of Medicine JingGangShan University Ji'an China. Division of Thoracic Surgery Chung Shan Medical University Hospital Taichung Taiwan. Department of Life Sciences National Tsing Hua University Hsinchu Taiwan. Cardiovascular Research Center School of Basic Medical Sciences Xi'an Jiaotong University Health Science Center Xi'an China. Department of Applied Chemistry National Chi Nan University Nantou Taiwan. Department of Cardiology The First Affiliated Hospital of Zhengzhou University Zhengzhou China. Institute of Bioinformatics and Structural Biology Department of Life Science National Tsing Hua University Hsinchu Taiwan. Department of Biomedical Sciences and Engineering Education and Research Center for Technology Assisted Substance Abuse Prevention and Management and Core Facilities for High Throughput Experimental Analysis National Central University Taoyuan Taiwan. Graduate Institute of Biomedical Sciences China Medical University Taichung Taiwan Translational Cell Therapy Center Department of Medical Research China Medical University Hospital Taichung Taiwan. Electronic address: scchiu@mail.cmu.edu.tw. Department of Applied Chemistry National Chi Nan University Nantou Taiwan. Electronic address: ctyu@ncnu.edu.tw.

CLNS1A is a chloride channel protein and an essential component of the methylosome complex, which additionally comprises PRMT5 and MEP50. In this study, we investigated its contribution to lung cancer and its potential as a therapeutic target. Analysis of transcriptomic datasets and western blotting revealed that CLNS1A, PRMT5, and MEP50 were overexpressed in lung cancer tissues, with elevated CLNS1A expression correlating with poor patient survival. CLNS1A overexpression enhanced platinum clearance from cells, increased the IC values for chemotherapy, and improved cell survival. Conversely, the knockdown of CLNS1A increased drug accumulation, reduced survival, and increased sensitivity to chemotherapy. The 3W mutant, a chloride channel-defective variant with steric hindrance at key bottleneck residues, impaired chloride ion transport, thereby reducing drug resistance, migration, and anchorage-independent growth. Mechanistically, CLNS1A promotes drug efflux through its chloride channel activity and activates the FAK-SRC-RAC1 pathway to enhance motility and clonogenicity. It also facilitates PRMT5-mediated RUVBL1 methylation to support anti-apoptotic DNA damage response signaling. In vivo, CLNS1A overexpression accelerated tumor growth and reduced survival, whereas CLNS1A knockdown sensitized tumors to cisplatin, enhancing therapeutic efficacy. These findings suggest that CLNS1A is a potential biomarker and therapeutic target, and its inhibition offers a strategy to overcome drug resistance and limit the metastatic progression of lung cancer.

关键词： Chemoresistance Chloride channel DNA damage response Lung cancer Metastasis

来源：评论

学校读者我要写书评

暂无评论

Survey of reduced workload and crewing strategies for ocean patrol vessels

引用

NAVAL ENGINEERS JOURNAL 2001年第2期113卷 29-44页

作者： Baker, C Krull, R Snyder, G Lincoln, W Malone, TB Clifford C. Baker CIE CHFEP is a senior staff scientist at Carlow International Incorporated. He has applied most of his 24 years of experience in the application of human engineering technology to maritime systems. Mr. Baker has directed much of Carlow's efforts to reduce ship workload and to improve human performance and maritime safety through application of human factors methods and data. He is a Certified Industrial Ergonomist (CIE) as well as a Certified Human Factors Engineering Professional (CHFEP). Both certifications were granted by Oxford Research where Mr. Baker also serves as an Advisory Board member. Russell D. Krull P.E. is a senior engineer with A&T/Proteus Engineering with more than 18 years of experi-ence in marine engineering naval architecture and program management including 16 years of active duty in the U.S. Coast Guard. Recent experience includes advanced ship design studies engineering software development technical support for the USMC Advanced Amphibious Assault Vehicle propulsion systems analyses ship structural engineering and cargo handling systems engineering. Mr. Krull has an M.S.E. in naval architecture and marine engineering and an M.S.E. in industrial and operations engineering from University of Michigan and a B.S. in ocean engineering from the U.S. Coast Guard Academy. Capt. Glenn L. Snyder USCG. Regrettably since this paper was originally written Capt. Snyder has passed away. At the time of his death he was an operations specialist assigned to the Coast Guard's Deepwater Capabilities Replacement Project as Chief of Human Systems Integration. He served as commanding officer of the patrol boat Cape George (WPB-95306) the icebreaking tug Biscayne Bay (WTGB-104) and the cutter Legare (WMEC-911). A 1975 graduate of the U.S. Coast Guard Academy Capt. Snyder held an M.A. in national security and strategic studies from the U.S. Naval War College and an M.A. in international relations from Salve Regina College. In addition he was a 1998 fellow of the Foreign Service

The U.S. Coast Guard is in the concept exploration phase of its Integrated Deepwater System (IDS) acquisition project. This project will define the next generation of surface, air and command, control, communications, computers, intelligence, surveillance, and reconnaissance (C4ISR) assets used to perform the Coast Guard's missions in the IDS environment (>50 NM off the U. S. coastline). As part of early technology investigations, the needs exist to: (1) analyze the workload requirements of the IDS, (2) identify alternative means to perform ship's work, and (3) optimize ship manning consistent with ship workload, performance criteria, and the available tools and equipment aboard. To reduce shipboard work requires an understanding of the mission and support requirements placed on the vessel and crew, how these requirements are currently met, and how requirements might otherwise be met to reduce workload and crew size. This study examined currently implemented workload and manpower reducing approaches of commercial maritime fleets, U.S. and foreign navies, and foreign coastguards. These approaches were analyzed according to evaluation criteria approved by the IDS acquisition project team. From this, strategies for shipboard work reduction that may be considered for adoption by the IDS were identified and analyzed according to performance and costs factors. Ten workload-reducing strategies were identified: damage control, bridge, multiple crewing, engineering, risk acceptance, modularity, deck, enabling technologies, ship/personnel readiness, and operability and maintainability.

关键词： Naval vessels

来源：评论

学校读者我要写书评

暂无评论

FOIL WEIGHT SAVING AND HYDROFOIL PERFORMANCE

引用

Naval Engineers Journal 1966年第5期78卷 905-913页

作者： RUFOLO, A. The Author received a BEE degree from the college of the City of New York pursued graduate studies at Brooklyn Polytechnic Institute holds a Professional Engineers License in New York State and is a member of the Research Society of America. Employed under various engineering titles at the U. S. Naval Applied Science Laboratory since 1941 he has held positions which embraced materials research in electrical insulation structural plastics and protective coatings. In 1963 he organized and directed a Bureau of Ships sponsored research program on materials for hydrofoils. Recently he assumed leadership of the Coatings Branch in the Material Sciences Division of the U. S. Naval Applied Science Laboratory.

来源：评论

学校读者我要写书评

暂无评论

structural basis and synergism of ATP and Na⁺ activation in bacterial K⁺ uptake system KtrAB

引用

Nature Communications 2024年第1期15卷 3850页

作者： Chiang, Wesley Tien Chang, Yao-Kai Hui, Wei-Han Chang, Shu-Wei Liao, Chen-Yi Chang, Yi-Chuan Chen, Chun-Jung Wang, Wei-Chen Lai, Chien-Chen Wang, Chun-Hsiung Luo, Siou-Ying Huang, Ya-Ping Chou, Shan-Ho Horng, Tzyy-Leng Hou, Ming-Hon Muench, Stephen P. Chen, Ren-Shiang Tsai, Ming-Daw Hu, Nien-Jen Graduate Institute of Biochemistry National Chung Hsing University Taichung 402202 Taiwan Institute of Biological Chemistry Academia Sinica Taipei 115201 Taiwan Department of Civil Engineering National Taiwan University Taipei 106319 Taiwan Department of Biomedical Engineering National Taiwan University Taipei 10663 Taiwan Life Science Group Scientific Research Division National Synchrotron Radiation Research Center Hsinchu 30092 Taiwan Institute of Molecular Biology National Chung Hsing University Taichung 402202 Taiwan Graduate Institute of Chinese Medical Science China Medical University Taichung 406040 Taiwan Department of Applied Mathematics Feng Chia University Taichung 407102 Taiwan Institute of Genomics and Bioinformatics National Chung Hsing University Taichung 402202 Taiwan School of Biomedical Sciences Faculty of Biological Sciences and the Astbury Centre for Structural Molecular Biology University of Leeds Leeds LS2 9JT United Kingdom Department of Life Science Tunghai University Taichung 407224 Taiwan Institute of Biochemical Sciences National Taiwan University Taipei 106319 Taiwan Ph.D Program in Translational Medicine National Chung Hsing University Taichung 402202 Taiwan

The K+ uptake system KtrAB is essential for bacterial survival in low K+ environments. The activity of KtrAB is regulated by nucleotides and Na+. Previous studies proposed a putative gating mechanism of KtrB regulated...

The K⁺ uptake system KtrAB is essential for bacterial survival in low K⁺ environments. The activity of KtrAB is regulated by nucleotides and Na⁺. Previous studies proposed a putative gating mechanism of KtrB regulated by KtrA upon binding to ATP or ADP. However, how Na⁺ activates KtrAB and the Na⁺ binding site remain unknown. Here we present the cryo-EM structures of ATP- and ADP-bound KtrAB from Bacillus subtilis (BsKtrAB) both solved at 2.8 Å. A cryo-EM density at the intra-dimer interface of ATP-KtrA was identified as Na⁺, as supported by X-ray crystallography and ICP-MS. Thermostability assays and functional studies demonstrated that Na⁺ binding stabilizes the ATP-bound BsKtrAB complex and enhances its K⁺ flux activity. Comparing ATP- and ADP-BsKtrAB structures suggests that BsKtrB Arg417 and Phe91 serve as a channel gate. The synergism of ATP and Na⁺ in activating BsKtrAB is likely applicable to Na⁺-activated K⁺ channels in central nervous system. © The Author(s) 2024.

关键词：

来源：评论

学校读者我要写书评

暂无评论

OpenMM 8: Molecular Dynamics Simulation with Machine Learning Potentials

arXiv

引用

arXiv 2023年

作者： Eastman, Peter Galvelis, Raimondas Peláez, Raúl P. Abreu, Charlles R.A. Farr, Stephen E. Gallicchio, Emilio Gorenko, Anton Henry, Michael M. Hu, Frank Huang, Jing Krämer, Andreas Michel, Julien Mitchell, Joshua A. Pande, Vijay S. Rodrigues, João P.G.L.M. Rodriguez-Guerra, Jaime Simmonett, Andrew C. Singh, Sukrit Swails, Jason Turner, Philip Wang, Yuanqing Zhang, Ivy Chodera, John D. De Fabritiis, Gianni Markland, Thomas E. Department of Chemistry Stanford University StanfordCA94305 United States Acellera Labs C Dr Trueta 183 Barcelona08005 Spain C Dr. Aiguader 88 Barcelona08003 Spain Chemical Engineering Department School of Chemistry Federal University of Rio de Janeiro Rio de Janeiro68542 Brazil Redesign Science Inc. 180 Varick St. New YorkNY10014 United States EaStCHEM School of Chemistry University of Edinburgh EH9 3FJ United Kingdom Department of Chemistry and Biochemistry Brooklyn College The City University of New York NY United States Ph.D. Program in Chemistry Ph.D. Program in Biochemistry The Graduate Center of the City University of New York New YorkNY United States Stream HPC Koningin Wilhelminaplein 1 - 40601 Amsterdam1062 HG Netherlands Computational and Systems Biology Program Sloan Kettering Institute Memorial Sloan Kettering Cancer Center New YorkNY10065 United States Key Laboratory of Structural Biology of Zhejiang Province School of Life Sciences Westlake University 18 Shilongshan Road Zhejiang Hangzhou310024 China Department of Mathematics and Computer Science Freie Universität Berlin Arnimallee 12 Berlin14195 Germany The Open Force Field Initiative Open Molecular Software Foundation DavisCA95616 United States Andreessen Horowitz 2865 Sand Hill Rd Menlo ParkCA94025 United States Department of Structural Biology Stanford University StanfordCA94305 United States Charité Universitätsmedizin Berlin In silico Toxicology and Structural Bioinformatics Virchowweg 6 Berlin10117 Germany Laboratory of Computational Biology National Heart Lung and Blood Institute National Institutes of Health BethesdaMD20892 United States Entos Inc. 9310 Athena Circle La Jolla CA92037 United States College of Engineering Virginia Polytechnic Institute State University BlacksburgVA24061 United States Simons Center for Computational Physical Chemistry Center for Data Science New York University 24 Waverly Place New YorkNY10004 United States T

Machine learning plays an important and growing role in molecular simulation. The newest version of the OpenMM molecular dynamics toolkit introduces new features to support the use of machine learning potentials. Arbitrary PyTorch models can be added to a simulation and used to compute forces and energy. A higher-level interface allows users to easily model their molecules of interest with general purpose, pretrained potential functions. A collection of optimized CUDA kernels and custom PyTorch operations greatly improves the speed of simulations. We demonstrate these features on simulations of cyclin-dependent kinase 8 (CDK8) and the green fluorescent protein (GFP) chromophore in water. Taken together, these features make it practical to use machine learning to improve the accuracy of simulations at only a modest increase in cost. Copyright © 2023, The Authors. All rights reserved.

关键词： Machine learning

来源：评论

学校读者我要写书评

暂无评论

Tissue Tension Permits Β-Catenin Phosphorylation to Drive Mesoderm Specification in Human Embryonic Stem Cells

SSRN

引用

SSRN 2023年

作者： Ayad, Nadia M.E. Lakins, Johnathon N. Ghagre, Ajinkya Ehrlicher, Allen J. Weaver, Valerie M. Graduate Program in Bioengineering University of California San Francisco University of California Berkeley San FranciscoCA94143 United States Center for Bioengineering and Tissue Regeneration Department of Surgery University of California San Francisco San FranciscoCA94143 United States Department of Bioengineering McGill University MontrealQCH3A 0E9 Canada Department of Bioengineering Department of Anatomy and Cell Biology Department of Biomedical Engineering Department of Mechanical Engineering Centre for Structural Biology Rosalind and Morris Goodman Cancer Institute McGill University MontrealQCH3A 1A3 Canada Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research University of California San Francisco San FranciscoCA94143 United States UCSF Comprehensive Cancer Center Helen Diller Family Cancer Research Center University of California San Francisco San FranciscoCA94143 United States Department of Bioengineering and Therapeutic Sciences Department of Radiation Oncology University of California San Francisco San FranciscoCA94143 United States

The role of morphogenetic forces in cell fate specification is an area of intense interest. Our prior studies suggested that the development of high cell-cell tension in human embryonic stem cells (hESC) colonies permits the Src-mediated phosphorylation of junctional β-catenin that accelerates its release to potentiate Wnt-dependent signaling critical for initiating mesoderm specification. Using an ectopically expressed nonphosphorylatable mutant of β-catenin (Y654F), we now provide direct evidence that impeding tension-dependent Src-mediated β-catenin phosphorylation impedes the expression of Brachyury (T) and the epithelial-to-mesenchymal transition (EMT) necessary for mesoderm specification. Addition of exogenous Wnt3a or inhibiting GSK3β activity rescued mesoderm expression, emphasizing the importance of force dependent Wnt signaling in regulating mechanomorphogenesis. Our work provides a framework for understanding tension-dependent β-catenin/Wnt signaling in the self-organization of tissues during developmental processes including gastrulation. © 2023, The Authors. All rights reserved.

关键词： Tissue

来源：评论

学校读者我要写书评

暂无评论

The mechanism of action of T-705 as a unique delayed chain terminator on influenza viral polymerase transcription

引用

Biophysical Chemistry 2021年 277卷 106652-106652页

作者： Wang, Yuqing Yuan, Congmin Xu, Xinzhou Chong, Tin Hang Zhang, Lu Cheung, Peter Pak-Hang Huang, Xuhui The Hong Kong University of Science and Technology-Shenzhen Research Institute Hi-Tech Park Nanshan Shenzhen 518057 China Bioengineering Graduate Program Department of Biological and Chemical Engineering The Hong Kong University of Science and Technology Clear Water Bay Hong Kong Department of Chemistry State Key Laboratory of Molecular Neuroscience The Hong Kong University of Science and Technology Kowloon Hong Kong State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences Fuzhou 350002 Fujian China University of Chinese Academy of Sciences Beijing 100049 China Department of Chemical Pathology The Chinese University of Hong Kong Prince of Wales Hospital Shatin New Territories Hong Kong Li Ka Shing Institute of Health Sciences Li Ka Shing Medical Sciences Building The Chinese University of Hong Kong Shatin New Territories Hong Kong

Favipiravir (T-705) has been developed as a potent anti-influenza drug and exhibited a strong inhibition effect against a broad spectrum of RNA viruses. Its active form, ribofuranosyl-triphosphate (T-705-RTP), functions as a competitive substrate for the RNA-dependent RNA polymerase (RdRp) of the influenza A virus (IAV). However, the exact inhibitory mechanisms of T-705 remain elusive and subject to a long-standing debate. Although T-705 has been proposed to inhibit transcription by acting as a chain terminator, it is also paradoxically suggested to be a mutagen towards IAV RdRp by inducing mutations due to its ambiguous base pairing of C and U. Here, we combined biochemical assay with molecular dynamics (MD) simulations to elucidate the molecular mechanism underlying the inhibitory functions exerted by T-705 in IAV RdRp. Our in vitro transcription assay illustrated that IAV RdRp could recognize T-705 as a purine analogue and incorporate it into the nascent RNA strand. Incorporating a single T-705 is incapable of inhibiting transcription as extra natural nucleotides can be progressively added. However, when two consecutive T-705 are incorporated, viral transcription is completely terminated. MD simulations reveal that the sequential appearance of two T-705 in the nascent strand destabilizes the active site and disrupts the base stacking of the nascent RNA. Altogether, our results provide a plausible explanation for the inhibitory roles of T-705 targeting IAV RdRp by integrating the computational and experimental methods. Our study also offers a comprehensive platform to investigate the inhibition effect of antivirals and a novel explanation for the designing of anti-flu drugs. © 2021

关键词： Chain terminator Influenza Mutagen RNA polymerase T-705

来源：评论

学校读者我要写书评

暂无评论

High-Resolution Imaging of Human Viruses in Liquid Droplets

引用

Advanced materials (Deerfield Beach, Fla.) 2021年第37期33卷 e2103221页

作者： G M Jonaid William J Dearnaley Michael A Casasanta Liam Kaylor Samantha Berry Madeline J Dukes Michael S Spilman Jennifer L Gray Deborah F Kelly Bioinformatics and Genomics Graduate Program Huck Institutes of the Life Sciences Pennsylvania State University University Park PA 16802 USA. Department of Biomedical Engineering Pennsylvania State University University Park PA 16802 USA. Materials Research Institute Pennsylvania State University University Park PA 16802 USA. Center for Structural Oncology Pennsylvania State University University Park PA 16802 USA. Molecular Cellular and Integrative Biosciences Graduate Program Huck Institutes of the Life Sciences Pennsylvania State University University Park PA 16802 USA. Protochips Inc. Morrisville NC 27560 USA. Direct Electron LP. San Diego CA 92128 USA.

Liquid-phase electron microscopy (LP-EM) is an exciting new area in the materials imaging field, providing unprecedented views of molecular processes. Time-resolved insights from LP-EM studies are a strong complement to the remarkable results achievable with other high-resolution techniques. Here, the opportunities to expand LP-EM technology beyond 2D temporal assessments and into the 3D regime are described. The results show new structures and dynamic insights of human viruses contained in minute volumes of liquid while acquired in a rapid timeframe. To develop this strategy, adeno-associated virus (AAV) is used as a model system. AAV is a well-known gene therapy vehicle with current applications involving drug delivery and vaccine development for COVID-19. Improving the understanding of the physical properties of biological entities in a liquid state, as maintained in the human body, has broad societal implications for human health and disease.

关键词： COVID-19 SARS-CoV-2 adeno-associated virus direct electron detector liquid-phase electron microscopy silicon nitride

来源：评论

学校读者我要写书评

暂无评论

Inside Front Cover: Volume 2 Issue 2

引用

SmartMat 2021年第2期2卷

作者： Jie Xu Xiaoya Cui Nan Liu Yanan Chen Hong-Wei Wang Ministry of Education Key Laboratory of Protein Sciences Beijing Advanced Innovation Center for Structural Biology School of Life Sciences Tsinghua University Beijing China Tsinghua-Peking Joint Center for Life Sciences Tsinghua University Beijing China School of Materials Science and Engineering Tsinghua University Tianjin China Hong-Wei Wang Ministry of Education Key Laboratory of Protein Sciences Beijing Advanced Innovation Center for Structural Biology School of Life Sciences Tsinghua University 100084 Beijing China. Joint Graduate Program of Peking-Tsinghua-NIBS School of Life Sciences Tsinghua University Beijing China Beijing Frontier Research Center for Biological Structures Tsinghua University Beijing China

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：