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55th SPSJ Annual Meeting

作者： Terada, Keiko Sato, Yuko Ohishi, Jun Kawamura, Kenji Kang, Jeong-Hun Asai, Daisuke Katayama, Yoshiki Graduate School of System Life Science Kyushu University CREST-JST Kyushu University Department of Applied Chemistry Faculty of Engineering Kyushu University Center for Future Chemistry Kyushu University Grant-in-Aid for the 21Th Century COE Program

We designed a gene carrier that can activate the delivered gene in response to the intercellular kinase signal. 'c-Src', which is non-receptor tyrosine kinase, is specifically activated within a cancer cell. We create gene carrier to express a therapeutics gene in response to 'c-Src'. We synthesize polymers that are grafted c-Src substrate peptide as an intercellular signal-response gene carrier. We will discuss the design of c-Src responsive carriers and their abilities for target signal specific gene regulation.

关键词： Genes

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A comparative study on sensitivity for biomolecular detection between gold nanoparticles coated and uncoated gold thin film using spectroscopic ellipsometry

A comparative study on sensitivity for biomolecular detectio...

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作者： Moirangthem, Rakesh Singh Chang, Yia-Chung Hsu, Shih-Hsin Wei, Pei-Kuen Research Centre for Applied Sciences Academia Sinica Taipei 115 Taiwan Nano Science and Technology Program Academia Sinica Taipei 115 Taiwan Taiwan International Graduate Program Academia Sinica Taipei 115 Taiwan Department of Engineering and System Science National Tsing Hua University Hsinchu 300 Taiwan

ISBN: (纸本)9781439834152

We investigate the plasmonic responses of gold nanoparticles (AuNP) coated and uncoated on 40nm gold thin film with surrounding medium having different refractive indices using Surface Plasmon Resonance (SPR) ellipsometry. The bulk sensitivities obtained from the measurements in both the cases are found to have same order of magnitude. However SPR dip in case of AuNP coated gold thin film has been shifted to longer wavelength (near IR) as compare to the bare gold thin film under the same environment and condition. Hence, it could provide a good platform to study biomolecular interaction where the absorption of light by the biomolucules is minimal. By monitor the induced changes in polarization state or phase of reflected light from the sample surface, which depend on surface properties of the sample, we use these changes as a sensor signal and compare that with theoretical simulation. This kind of characterization technique is non-destructive, label free and it has high sensitivity and sub-nanometer thickness resolution.

关键词： Surface plasmon resonance

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3D scaffolds-specific cellular mechanoresponse as a pivotal regulating factor in tissue engineering

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JMST Advances 2024年第2期6卷 121-134页

作者： Ahn, Yejin Chang, Hyewon Baek, Jieung Department of Biological Sciences Pusan National University Busan Republic of Korea Division of Mechanical and Biomedical Engineering Ewha Womans University Seoul Republic of Korea Graduate Program in System Health Science and Engineering Ewha Womans University Seoul Republic of Korea

In tissue engineering, the mechanical properties of the extracellular matrix (ECM) or scaffolds have increasingly been considered to impact therapeutic efficacy by regulating cell behaviors, including differentiation, proliferation, migration, and adhesion. However, the understanding of how cells sense, integrate, and convert the mechanical cues from the ECM cues into biochemical signals to control certain cell behaviors is still elusive, especially in 3D, which more closely mimics the natural microenvironment than 2D systems. This review highlights the key differences between 2 and 3D in the contexts of mechanoregulative cell behaviors such as cell adhesion, spreading, migration, and force transmission. Furthermore, critical designing factors that needs to be considered for the fabrication of 3D tissue engineering scaffolds is discussed: stiffness, viscoelasticity, degradability, and the immobilization of biomolecules. Although mechanotransduction in 3D is actively being studied, understanding cellular mechanotransduction in 3D and designing of mechanoregulative 3D scaffolds still presents several challenges, including varying mechanical properties depending on different tissues, dynamic mechanical environments, and integration of multimodal cues. Interdisciplinary methodologies encompassing material engineering, cell biology, and mechanical engineering would serve to mitigate these challenges and augment our understanding of mechanoregulation governing cellular behaviors, thus fostering advancements in biomedical applications in the future.

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High-Resolution Hydrogen Molecule Detection Utilizing a Nanocandle-Based Optical Sensor 16

High-Resolution Hydrogen Molecule Detection Utilizing a Nano...

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16th Pacific Rim Conference on Lasers and Electro-Optics, CLEO-PR 2024

作者： Park, Nu-Ri Kim, Min-Joong Lee, Jongsu Seo, Minah Ryu, Yong-Sang Kim, Myung-Ki KU-KIST Graduate School of Converging Science and Technology Korea University Seoul02841 Korea Republic of Korea Institute of Science and Technology Sensor System Research Center Seoul02792 Korea Republic of Northwestern University Department of Electrical Engineering and Computer Science EvanstonIL60208 United States School of Biomedical Engineering Korea University Seoul02481 Korea Republic of Interdisciplinary Program in Precision Public Health Korea University Seoul02481 Korea Republic of

Our research introduces a novel method for safe hydrogen detection. We've developed an advanced nano-candle sensor, combining Pd with nano-candles, enabling accurate detection of low-concentration hydrogen ( ©... 详细信息

ISBN: (纸本)9798350372076

关键词： Nanoclay

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Chaperone proteins as ameliorators of α-synuclein-induced synaptic pathologies: insights into Parkinson’s disease

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Neural Regeneration Research 2021年第6期16卷 1198-1199页

作者： Susan M.L.Banks Audrey T.Medeiros Rui Sousa Eileen M.Lafer Jennifer R.Morgan Department of Biology Florida Southern CollegeLakelandFLUSA Neuroscience Graduate Program Brown UniversityProvidenceRIUSA Department of Biochemistry and Structural Biology and Center for Biomedical Neuroscience The University of Texas Health Science Center at San AntonioSan AntonioTXUSA The Eugene Bell Center for Regenerative Biology&Tissue Engineering Marine Biological LaboratoryWoods HoleMAUSA

α-Synuclein accumulation causes synaptic vesicle trafficking defects and may underlie neurodegenerative disorders:Neurodegenerative disorders,such as Parkinson’s disease(PD)and other synucleinopathies,impact the lives of millions of patients and their *** include PD,dementia with Lewy Bodies(DLB),multiple system atrophy,and several Alzheimer’s Disease *** are clinically characterized by intracellular inclusions called Lewy Bodies,which are rich in atypical aggregates of the protein α-*** dopaminergic neurons in the substantia nigra are particularly susceptible toα-synuclein-induced aggregation and neurodegeneration,glutamatergic neurons in other brain regions(***)are also frequently affected in PD and other synucleinopathies(Schulz-Schaeffer 2010).

关键词： cortex Alzheimer insight

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Learner Action Patterns in the Problem-Solving Process Related to program Code Composition Based on Tracking system Activities 7

Learner Action Patterns in the Problem-Solving Process Relat...

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7th International Conference on Informatics and Computing, ICIC 2022

作者： Syahidi, Aulia Akhrian Supianto, Ahmad Afif Hirashima, Tsukasa Watanobe, Yutaka Politeknik Negeri Banjarmasin Smart City Information System Applied Undergraduate Program Banjarmasin City Indonesia Research Center for Data and Information Sciences Bandung City Indonesia Graduate School of Advanced Science and Engineering Hiroshima University Kagamiyama Learning Engineering Laboratory Higashihiroshima Japan University of Aizu Division of Information Systems Department of Computer Science and Engineering Fukushima AizuWakamatsu Japan

ISBN: (纸本)9798350345711

Learning activities are an indicator of the learner's desire to learn during the learning process. The pattern of learner action is related to learning activities. In this case, in extracting the learning process, it is necessary to collect a lot of data through analysis of the learning process. The purpose of this study is to recommend and report the performance of an activity tracking system equipped with visual artifacts as an educational data mining approach to analyze action patterns when learners complete the arrangement of program code lines in each programming problem. In this study, data were taken from activity recordings when learners used interactive learning media for a basic programming subject called TOLSYASUPI-EduMed which had problem-solving learning models embedded in their interactions. Learning Analytics is used as a method of this research and data relationships from learner actions during the learning process using the 'if-then' rule. Log data is used for recording and detecting activities carried out by learners. We confirm that the results of the study are based on the findings of the data relationship that if the lines of program code are too long (more than five lines) then almost all learners experience a bottleneck condition. The completion time of each question and the number of iterations in completing the program code lines for each question have also been recorded and have a pattern of connection between the data. The information that has been obtained is then forwarded to teachers or stakeholders as key information to make appropriate feedback to learners based on the results as a means of analyzing and evaluating the programming learning process. © 2022 IEEE.

关键词： Data mining

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Analysis of the synchrotron radiation from segmented undulator in double-mini beta function 8

Analysis of the synchrotron radiation from segmented undulat...

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8th International Particle Accelerator Conference, IPAC 2017

作者： Luo, H.W. Chung, T.Y. Hwang, C.S. Lee, C.H. Graduate Program in Science and Technology of Synchrotron Light Source National Tsing Hua University Hsinchu Taiwan National Synchrotron Radiation Research Center Hsinchu Taiwan Department of Electrophysics National Chiao Tung University Hsinchu Taiwan Department of Engineering and System Science National Tsing Hua University Hsinchu Taiwan

ISBN: (纸本)9783954501823

Three long straight sections with double-mini beta-y lattice were created in the Taiwan Photon Source (TPS) for which the effects of focusing elements and phase shifters between the collinear undulators result in incorrect calculations of the brilliance while assuming a Gaussian-approximation. Therefore, an on-axis Wigner distribution function (WDF), which includes effects of wave phenomena, is a natural way to measure the intensity of synchrotron radiation and is used in this article as the definition of brilliance. © 2017 CC-BY-3.0 and by the respective authors

关键词： Synchrotron radiation

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Robust H_2 Control of Active Suspension -Improvement of Ride Comfort and Driving Stability

Robust H_2 Control of Active Suspension -Improvement of Ride...

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Conference on Control Applications

作者： Kohei Suzuki Tatsuo Toda Gan Chen Isao Takami Department of System Design and Engineering Graduate Program of Mechatronics Nanzan University Aichi Japan Faculty of Science and Engineering Nanzan University Aichi Japan

ISBN: (纸本)9781479977970

This paper suggests a method of robust control for an active suspension to improve both of the ride comfort and the driving stability using half car model. The ride comfort is evaluated by the vertical acceleration and the pitch acceleration of the human body. The driving stability is evaluated by the vertical force of front and rear wheels. The purpose of this paper is to improve the ride comfort and the driving stability by using state feedback. On the other hand, the robust stability is also important factor to evaluate the performance of the car. In this study, the front and rear weights of car body are considered as uncertain parameters depending on the passengers and the loads. Their weights influence on the pitch motion of the car body. The robust H_2 controller is designed to guarantee the robust stability for the system with uncertain parameters with polytopic representation. These problems are solved by a finite set of Linear Matrix Inequality (LMI). The effectiveness of the proposed method is illustrated by simulations and experiments.

关键词： comfort driving stability experiments

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Properties of synchrotron radiation from segmented undulators based on a Wigner distribution function 7

Properties of synchrotron radiation from segmented undulator...

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7th International Particle Accelerator Conference, IPAC 2016

作者： Luo, H.W. Chung, T.Y. Lee, C.H. Hwang, C.S. Graduate Program in Science and Technology of Synchrotron Light Source National Tsing Hua University Hsinchu Taiwan National Synchrotron Radiation Research Center Hsinchu Taiwan Department of Engineering and System Science National Tsing Hua University Hsinchu Taiwan Department of Electrophysics National Chiao Tung University Hsinchu Taiwan

ISBN: (纸本)9783954501472

Three long straight sections with a double mini-βylattice were designed in Taiwan Photon Source. For the purpose to understand whether the brilliance can be enhanced or not when two collinear undulators were installed in the double mini-βysection. The method of Wigner distribution function (WDF) is a natural way to describe a synchrotron radiation source. The brilliance is thereby calculable without a Gaussian approximation used in a conventional manner. Hence the WDF is developed to calculate the brilliance for the two collinear undulators in the double mini-βysection. Some important optical properties such as the degree of coherence can be directly calculated with this method. We use it as an example to investigate the properties of radiation from a segmented undulator. Copyright © 2016 CC-BY-3.0 and by the respective authors.

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Materials Discovery with Extreme Properties via Reinforcement Learning-Guided Combinatorial Chemistry

arXiv

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arXiv 2023年

作者： Kim, Hyunseung Choi, Haeyeon Kang, Dongju Lee, Won Bo Na, Jonggeol School of Chemical and Biological Engineering Seoul National University Korea Republic of Department of Chemical Engineering and Materials Science Ewha Womans University Korea Republic of Graduate Program in System Health Science and Engineering Ewha Womans University Korea Republic of

The goal of most materials discovery is to discover materials that are superior to those currently known. Fundamentally, this is close to extrapolation, which is a weak point for most machine learning models that learn the probability distribution of data. Herein, we develop reinforcement learning-guided combinatorial chemistry, which is a rule-based molecular designer driven by trained policy for selecting subsequent molecular fragments to get a target molecule. Since our model has the potential to generate all possible molecular structures that can be obtained from combinations of molecular fragments, unknown molecules with superior properties can be discovered. We theoretically and empirically demonstrate that our model is more suitable for discovering better compounds than probability distribution-learning models. In an experiment aimed at discovering molecules that hit seven extreme target properties, our model discovered 1,315 of all target-hitting molecules and 7,629 of five target-hitting molecules out of 100,000 trials, whereas the probability distribution-learning models failed. Moreover, it has been confirmed that every molecule generated under the binding rules of molecular fragments is 100% chemically valid. To illustrate the performance in actual problems, we also demonstrate that our models work well on two practical applications: discovering protein docking molecules and HIV inhibitors. © 2023, CC BY-NC-SA.

关键词： Probability distributions

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