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Addressing Diversity in PTSD Treatment: Clinical Considerations and Guidance for the Treatment of PTSD in LGBTQ Populations

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Current Treatment Options in Psychiatry 2020年第2期7卷 53-69页

作者： Livingston, Nicholas A. Berke, Danielle Scholl, James Ruben, Mollie Shipherd, Jillian C. National Center for PTSD Behavioral Science Division Boston MA United States Department of Psychiatry Boston University School of Medicine Boston MA United States VA Boston Healthcare System Boston MA United States Hunter College of the City University of New York New York City NY United States The Graduate Center City University of New York New York City NY United States Department of Psychology University of Maine Orono ME United States National Center for PTSD Women’s Health Sciences Division Boston MA United States Lesbian Gay Bisexual and Transgender (LGBT) Health Program Veterans Health Administration Washington DC United States

Purpose of review: Trauma exposure is widespread but is especially common among lesbian, gay, bisexual, transgender, and queer (LGBTQ) individuals. LGBTQ individuals also experience higher rates of discrimination, victimization, and minority stress which can complicate posttraumatic stress disorder (PTSD) treatment but also represent independent intervention targets. In this review, we highlight existing evidence-based practices, current limitations, and provide recommendations for care in the absence of established guidelines for treatment PTSD among LGBTQ patients. Recent findings: Trauma-focused therapies (e.g., CPT, PE) and medications (e.g., SSRIs, SNRIs) have shown benefit for people with PTSD. However, evaluations of these interventions have failed to examine the role of LGBTQ identities in recovery from trauma, and existing PTSD treatments do not account for ongoing threat to safety or the pervasive minority stress experienced by LGBTQ patients. In addition, many LGBTQ patients report negative experiences with healthcare, necessitating increased education and cultural awareness on the part of clinicians to provide patient-centered care and, potentially, corrective mental health treatment experiences. Summary: Providers should routinely assess trauma exposure, PTSD, and minority stress among LGBTQ patients. We provide assessment and screening recommendations, outline current evidence-based treatments, and suggest strategies for integrating existing treatments to treat PTSD among LGBTQ patients. © 2020, Springer Nature Switzerland AG.

关键词： Assessment Evidence-based treatment LGBT Minority stress PTSD

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Modulating motor cortical oscillation with coordinated reset multifocal transcranial magnetic stimulation

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Journal of neurophysiology 2023年第5期129卷 1061-1071页

作者： Kai-Hsiang Stanley Chen Tzu-Kang Hung Rupesh Kumar Chikara Yu-Ting Kuo Yi-Ping Liu Yan-Siou Dong Yih-Ru Wu Li-Wei Ko Ying-Zu Huang Robert Chen Department of Neurology National Taiwan University Hospital Hsinchu Branch Hsinchu Taiwan. Institute of Bioinformatics and Systems Biology National Yang Ming Chiao Tung University Hsinchu Taiwan. Center for Intelligent Drug Systems and Smart Bio-devices (IDS2B) National Yang Ming Chiao Tung University Hsinchu Taiwan. Jane and John Justin Neurosciences Center Cook Children's Health Care System Fort Worth Texas United States. Department of Bioengineering University of Texas at Arlington Arlington Texas United States. Department of Neurology Chang Gung Memorial Hospital and Chang Gung University College of Medicine Taoyuan Taiwan. Institute of Electrical and Control Engineering National Yang Ming Chiao Tung University Hsinchu Taiwan. Neuroscience Research Center and Department of Neurology Chang Gung Memorial Hospital and Chang Gung University College of Medicine Taoyuan Taiwan. Institute of Cognitive Neuroscience College of Health Science and Technology Taoyuan Taiwan. Krembil Research Institute University Health Network Toronto Ontario Canada. Division of Neurology Department of Medicine University of Toronto Toronto Ontario Canada. Edmond J. Safra Program in Parkinson's Disease University Health Network Toronto Ontario Canada.

According to the theory of coordinated reset (CR) stimulation, multifocal bursts of stimuli delivered in a random order with a specific interval may reduce the resonance power of the oscillatory generator in the epicenter. We develop a noninvasive coordinated multifocal burst stimulation (COMBS) with three repetitive transcranial stimulation machines based on CR theory to modulate the target frequency in the primary motor cortex and to assess its effect on motor cortical excitability in separate experiments. Electroencephalography and electromyography were recorded in 16 healthy participants during a finger-tapping task, both before and after the intervention. The resting oscillatory power at the targeted frequency was not changed by COMBS. α-Band power was increased in both preparation and movement stages and the low β-band power was increased in the movement stage of the finger tapping task. The extent of low β-band event-related desynchronization was reduced by COMBS. There were no changes in reaction time, but there was a trend for a reduced error rate after COMBS. In another 14 healthy participants, there were no significant changes in cortical excitability before and after COMBS measured by rest motor threshold, short interval intracortical inhibition, short interval intracortical facilitation, and cortical silent period. The result indicates that COMBS may modify the cortical oscillatory power and its perturbation within specific movement stage. This is the first study, to our knowledge, to apply coordinated reset (CR) neuromodulation to the motor cortex with three repetitive transcranial magnetic stimulation (rTMS) stimulators to assess its effect on cortical oscillation. The results revealed enhancement of α-band power specifically in preparation and movement stages and low β-band power in the movement stage of a motor task. It postulated that CR stimulation may modify the motor cortical oscillation in the specific movement stages.

关键词： coordinated reset event-related desynchronization low beta oscillation motor cortical excitability repetitive transcranial magnetic stimulation (rTMS)

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Relative humidity levels associated with increases in microbial growth and MVOC emissions in carpet and drywall 16

Relative humidity levels associated with increases in microb...

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16th Conference of the International Society of Indoor Air Quality and Climate: Creative and Smart Solutions for Better Built Environments, Indoor Air 2020

作者： Haines, Sarah R. Hall, Emma C. Misztal, Pawel K. Goldstein, Allen H. Adams, Rachel I. Dannemiller, Karen C. Environmental Sciences Graduate Program Ohio State University ColumbusOH43210 United States Department of Civil Environmental and Geodetic Engineering College of Engineering Ohio State University ColumbusOH43210 United States Division of Environmental Health Sciences College of Public Health Ohio State University ColumbusOH43210 United States Department of Civil Architectural and Environmental Engineering University of Texas at Austin AustinTX78712 United States Department of Environmental Science Policy and Management University of California BerkeleyCA94720 United States Department of Plant and Microbial Biology University of California BerkeleyCA94720 United States

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Magnesium-enriched deep-sea water inhibits NLRP3 inflammasome activation and dampens inflammation

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Heliyon 2024年第15期10卷 e35136页

作者： Wang, Hsueh-Hsiao Huang, Chi-Ruei Lin, Hsin-Chung Lin, Hsin-An Chen, Yu-Jen Tsai, Kuen-Jou Shih, Chieh-Tien Huang, Kuo-Yang Ojcius, David M. Tsai, Ming-Hang Tseng, Kuang-Wen Chen, Lih-Chyang Department of Medicine MacKay Medical College Master Program in Biomedicine College of Science and Engineering National Taitung University Biomedicine Agriculture and Food Sciences Research Center College of Science and Engineering National Taitung University Graduate Institute of Pathology and Parasitology National Defense Medical Center Division of Clinical Pathology Department of Pathology Tri-Service General Hospital National Defense Medical Center Division of Infection Department of Medicine Tri-Service General Hospital SongShan Branch National Defense Medical Center Department of Health Promotion and Health Education National Taiwan Normal University Department of Medical Research MacKay Memorial Hospital Department of Radiation Oncology MacKay Memorial Hospital Department of Artificial Intelligence and Medical Application MacKay Junior College of Medicine Nursing and Management Department of Medical Research China Medical University Hospital Department of Laboratory Medicine MacKay Memorial Hospital Department of Nursing MacKay Medical College Department of Biomedical Sciences University of the Pacific Arthur Dugoni School of Dentistry Department of Medicine Tri-Service General Hospital SongShan Branch National Defense Medical Center

The NLRP3 inflammasome is an essential component of the innate immune system, but excessive activation can lead to inflammatory diseases. Ion fluxes across the plasma membrane or from intracellular stores are known to regulate NLRP3 inflammasome activation. Deep-sea water (DSW) contains high concentrations of many mineral ions, which could potentially influence NLRP3 inflammasome activation. However, the impact of DSW on NLRP3 inflammasome activation has not been investigated. Here, we demonstrated that DSW with water hardness levels up to 500 mg/L did not affect cell viability or the expression of NLRP3 inflammasome components in macrophages derived from THP-1 cells. However, the DSW significantly inhibited IL-1β secretion and caspase-1 activation in response to NLRP3 activators such as nigericin, ATP, or monosodium urate (MSU) crystals. Mechanically, it was discovered that the presence of 5 mM magnesium ions (Mg2⁺), equivalent to the Mg2⁺ concentration found in the DSW with a water hardness of 500 mg/L, inhibits NLRP3 inflammasome activation. This indicates that Mg2⁺ contributes to the mechanism by which DSW mitigates NLRP3 inflammasome activation. Moreover, DSW administration effectively lessens MSU-triggered peritonitis in mice, a commonly used model for examining the impacts of NLRP3 inflammasome activation. These results show that DSW enriched with Mg²⁺ could potentially be beneficial in modulating NLRP3 inflammasome-associated diseases. © 2024 The Authors

关键词： Deep-sea water Macrophages Magnesium NLRP3 inflammasome

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Simple One-Pot Assay for Visual and Smartphone-Based Quantification of Human Albumin in Urine and Biological Fluids

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Talanta 2025年

作者： Nopchulee Cheeveewattanagul Oranut Warachit Paskorn Muangphrom Patsamon Rijiravanich Sensor Technology Laboratory Pilot Plant Development and Training Institute King Mongkut’s University of Technology Thonburi (KMUTT) Bangkhuntien Campus Bangkok 10150 Thailand Department of Clinical Pathology Phramongkutklao Hospital and College of Medicine Bangkok 10400 Thailand Nanoscience and Nanotechnology Graduate Program Faculty of Science KMUTT Bangmod Campus Bangkok 10140 Thailand Industrial Sensor Technology Research Team Biochemical Engineering and System Biology Research Group National Center for Genetic Engineering and Biotechnology National Science and Technology Development Agency at KMUTT (Bangkhuntien Campus) Bangkok 10150 Thailand

This study introduces a simple and effective one-pot assay for the quantification of human albumin (HA) using H8 aptamer-modified magnetic beads (H8Apt-MB-HA), applicable across various biological fluids, including urine, serum, and sweat. Upon binding to HA, the aptamer-bead complexes exhibit concentration-dependent aggregation: well-dispersed at low HA levels and clustered at higher concentrations, with rapid sedimentation under a magnetic field in U-shaped well plates. These aggregation patterns are visually discernible, enabling rapid qualitative screening without the need for complex instrumentation. For quantitative analysis, digital images captured by a smartphone or a plate scanner (Cytation™ 5) are processed using ImageJ software, allowing for accurate signal quantification. The top and bottom-view assay achieves a detection limit of 5.9 and 6.5 mg L -1 and demonstrates robust performance across a urinary pH range of 5.0 to 7.0. Minimal cross-reactivity with other biological components confirms the aptamer’s high specificity. Clinical validation with patient urine samples shows excellent correlation with standard immunoturbidimetric methods, underscoring the assay’s potential for point-of-care testing. This approach supports immediate interpretation and clinical decision making, especially valuable in resource-limited settings and for routine monitoring of kidney-related disorders.

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Microfluidic nanodevices for drug sensing and screening applications

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Biosensors and Bioelectronics 2023年 219卷 114783页

作者： Pal, Arnab Kaswan, Kuldeep Barman, Snigdha Roy Lin, Yu-Zih Chung, Jun-Hsuan Sharma, Manish Kumar Liu, Kuei-Lin Chen, Bo-Huan Wu, Chih-Cheng Lee, Sangmin Choi, Dongwhi Lin, Zong-Hong Institute of Biomedical Engineering National Tsing Hua University Hsinchu30013 Taiwan International Intercollegiate PhD Program National Tsing Hua University Hsinchu30013 Taiwan Department of Power Mechanical Engineering National Tsing Hua University Hsinchu30013 Taiwan Department of Materials Science and Engineering National Tsing Hua University Hsinchu30013 Taiwan Department of Chemistry National Tsing Hua University Hsinchu30013 Taiwan Frontier Research Center on Fundamental and Applied Sciences of Matters National Tsing Hua University Hsinchu30013 Taiwan Department of Gastroenterology and Hepatology Chang Gung Memorial Hospital Linkou Medical Center Taoyuan333 Taiwan Center of Quality Management National Taiwan University Hospital Hsinchu Branch Hsinchu30059 Taiwan College of Medicine National Taiwan University Taipei10051 Taiwan Institute of Cellular and System Medicine National Health Research Institute Zhunan 35053 Taiwan School of Mechanical Engineering Chung-Ang University Seoul06974 Korea Republic of Kyung Hee University Gyeonggi 17104 Korea Republic of

The outbreak of pandemics (e.g., severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 in 2019), influenza A viruses (H1N1 in 2009), etc.), and worldwide spike in the aging population have created unprecedented urgency for developing new drugs to improve disease treatment. As a result, extensive efforts have been made to design novel techniques for efficient drug monitoring and screening, which form the backbone of drug development. Compared to traditional techniques, microfluidics-based platforms have emerged as promising alternatives for high-throughput drug screening due to their inherent miniaturization characteristics, low sample consumption, integration, and compatibility with diverse analytical strategies. Moreover, the microfluidic-based models utilizing human cells to produce in-vitro biomimetics of the human body pave new ways to predict more accurate drug effects in humans. This review provides a comprehensive summary of different microfluidics-based drug sensing and screening strategies and briefly discusses their advantages. Most importantly, an in-depth outlook of the commonly used detection techniques integrated with microfluidic chips for highly sensitive drug screening is provided. Then, the influence of critical parameters such as sensing materials and microfluidic platform geometries on screening performance is summarized. This review also outlines the recent applications of microfluidic approaches for screening therapeutic and illicit drugs. Moreover, the current challenges and the future perspective of this research field is elaborately highlighted, which we believe will contribute immensely towards significant achievements in all aspects of drug development. © 2022 Elsevier B.V.

关键词： Microfluidics

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Controlled tempering of lipid concentration and microbubble shrinkage as a possible mechanism for fine-tuning microbubble size and shell properties

arXiv

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arXiv 2023年

作者： Zalloum, Intesar O. Sojahrood, Amin Jafari Paknahad, Ali A. Kolios, Michael C. Tsai, Scott S.H. Karshafian, Raffi Department of Physics Toronto Metropolitan University TorontoONM5B 2K3 Canada Department of Mechanical and Industrial Engineering Toronto Metropolitan University 350 Victoria Street TorontoONM5B 2K3 Canada A Partnership Between Toronto Metropolitan University St. Michael's Hospital 209 Victoria Street TorontoONM5B 1T8 Canada Keenan Research Centre for Biomedical Science Unity Health Toronto 209 Victoria Street TorontoONM5B 1W8 Canada Graduate Program in Biomedical Engineering Toronto Metropolitan University 350 Victoria Street TorontoONM5B 2K3 Canada

The acoustic response of microbubbles (MBs) depends on their resonance frequency, which is dependent on MB size and shell properties. Monodisperse MBs with tunable shell properties are thus desirable for optimizing and controlling MB behavior in acoustics applications. By utilizing a novel microfluidic method that uses lipid concentration to control MB shrinkage, we generate monodisperse MBs of four different initial diameters at three lipid concentrations (5.6, 10.0, and 16.0 mg/mL) in the aqueous phase. Following shrinkage, we measure MB resonance frequency and determine its shell stiffness and viscosity. The study demonstrates that we can generate monodisperse MBs of specific sizes and tunable shell properties by controlling MB initial diameter and aqueous phase lipid concentration. Our results indicate that the resonance frequency increases by 180-210% with increasing lipid concentration (from 5.6 to 16.0 mg/mL) while bubble diameter is kept constant. Additionally, we find that the resonance frequency decreases by 260-300% with increasing MB final diameter (from 5 to 12 μm), while lipid concentration is held constant. For example, our results depict that the resonance frequency increases by ~195% with increasing lipid concentration from 5.6 to 16.0 mg/mL, for ~11 μm final diameter MBs. Additionally, we find that the resonance frequency decreases by ~275% with increasing MB final diameter from 5 to 12 μm, when we use a lipid concentration of 5.6 mg/mL. We also determine that MB shell viscosity and stiffness increase with increasing lipid concentration and MB final diameter, and the level of change depends on the degree of shrinkage experienced by MB. Specifically, we find that by increasing the concentration of lipids from 5.6 to 16.0 mg/mL, the shell stiffness and viscosity of ~11 μm final diameter MBs increase by ~400% and ~200 %, respectively. This study demonstrates the feasibility of fine-tuning the MB acoustic response to ultrasound by tailoring MB initial

关键词： Shrinkage

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Transferable individual brain regional atrophy progression prediction model using structural connectome

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Alzheimer's & Dementia 2023年第S14期19卷

作者： Yu Xiao Joanna Su Xian Chong Bing Cai Kok Kwun Kei Ng Christopher Li-Hsian Chen Juan Helen Zhou Quantitative Biology and Medicine Program Duke-NUS Medical School Singapore Singapore Centre for Sleep and Cognition & Centre for Translational Magnetic Resonance Research Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore Correspondece Department of Pharmacology Clinical Research Centre National University Health System National University of Singapore Singapore Singapore Memory Ageing and Cognition Centre National University Health System Singapore Singapore Electrical and Computer Engineering National University of Singapore Singapore Singapore Integrative Sciences and Engineering Programme (ISEP) NUS Graduate School National University of Singapore Singapore Singapore

Background Brain microstructure, as measured by diffusion MR imaging (dMRI), is an early biomarker of Alzheimer’s disease (AD) and has been previously demonstrated to predict whole brain atrophy and cognition. The network-based neurodegeneration hypothesis posits that the onset of AD occurs within key vulnerable regions, whose network connectivity guides the spread of atrophy into new regions. Graph convolutional network (GCN) models can mimic this spread through its convolution process. Here we present a GCN-based model to predict future individual nodal atrophy and disease progression across the AD spectrum using structural connectome. Method We analyzed 371 participants with baseline dMRI scans (154 cognitively normal (CN), 161 mild cognitive impairment (MCI), 56 AD) and longitudinal T1 scans (2.7±1.2 years) from the ADNI study. To predict annual nodal atrophy rates (126 nodes) from baseline structural connectivity (SC), we constructed a two-layer GCN followed by multilayer perceptron (GCN-MLP). Five-fold nested cross-validation and Optuna were used for hyperparameter tuning. We applied the trained GCN-MLP model to predict future disease progression via transfer learning. GNNExplainer was used to identify the predictive SC features for atrophy or cognition. The GCN-MLP model was validated in another independent dataset from Singapore (MACC) with 226 participants (61 CN, 112 MCI, 53 AD, follow-up period of T1 scans (3.1±1.3 years)) using transfer learning. Result The proposed GCN-MLP model predicted the annual rate of regional atrophy at the individual level in the main (R = 0.5407±0.0480; MAE = 0.0013±0.0001; EV = 0.2930±0.0516) and validation (R = 0.5323±0.0564; MAE = 0.0009±0.0001; EV = 0.2808±0.0559) datasets (Table 1; Figure 1). Graph edge SC of the target network contributed most to the atrophy prediction of its own network (Figure 2A&C). Nodal feature SC in hippocampus, striatum, and temporal network were major predictors of atrophy progression across all 1

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Therapeutic targeting of hepatocellular carcinoma cells with antrocinol, a novel, dual-specificity, small-molecule inhibitor of the KRAS and ERK oncogenic signaling pathways

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Chemico-Biological Interactions 2023年第1期370卷 110329页

作者： Hsu, Chia-Hung Weng, Pei-Wei Chen, Ming-Yao Yeh, Chi-Tai Setiawan, Syahru Agung Yadav, Vijesh Kumar Wu, Alexander T.H. Tzeng, David T.W. Gong, Jian-Xian Yang, Zhen Tzeng, Yew-Min Department of Emergency Medicine Shuang Ho Hospital Taipei Medical University New Taipei City 23561 Taiwan Graduate Institute of Injury Prevention and Control College of Public Health Taipei Medical University Taipei City 11031 Taiwan Department of Emergency Medicine School of Medicine Taipei Medical University Taipei 11031 Taiwan Department of Orthopaedics School of Medicine College of Medicine Taipei Medical University Taipei 11031 Taiwan Department of Orthopaedics Shuang Ho Hospital Taipei Medical University New Taipei City 23561 Taiwan Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering Taipei Medical University Taipei 11031 Taiwan Division of Gastroenterology and Hepatology Department of Internal Medicine Shuang Ho Hospital New Taipei City 23561 Taiwan Division of Gastroenterology and Hepatology Department of Internal Medicine School of Medicine College of Medicine Taipei Medical University Taipei 11031 Taiwan Continuing Education Program of Food Biotechnology Applications College of Science and Engineering National Taitung University Taitung 95092 Taiwan International Ph.D. Program in Medicine College of Medicine Taipei Medical University Taipei 11031 Taiwan Ph.D. Program of Translational Medicine College of Medical Science and Technology Taipei Medical University Taipei 11031 Taiwan School of Life Sciences The Chinese University of Hong Kong 999077 Hong Kong Lifebit London EC2A 2AP United Kingdom Laboratory of Chemical Genomics School of Chemical Biology and Biotechnology Peking University Shenzhen Graduate School Shenzhen 518055 China State Key Laboratory of Bioorganic Chemistry and Molecular Engineering of the Ministry of Education and Beijing National Laboratory for Molecular Science College of Chemistry and Molecular Engineering Peking University Beijing 100871 China Shenzhen Bay Laboratory Shenzhen 518055 China Department of Applied Science National Taitung University Taitung

Until recently, sorafenib has been the only treatment approved by the U.S. Food and Drug Administration for patients with advanced hepatocellular carcinoma (HCC). Some patients, however, exhibit resistance to this treatment and subsequently experience cancer progression, recurrence, or death. Therefore, identifying a new alternative treatment for patients with little or no response to sorafenib treatment is vital. In this study, we explored the therapeutic potential and underlying molecular mechanism of antrocinol ((3aS,4R,6aS,10aR)-4-(hydroxymethyl)-7,7-dimethyldecahydro-1H-naphtho[1,8a-c]furan-1-one) in patients with HCC. The results indicated that antrocinol was more therapeutically effective than antrocin, Stivarga, and sorafenib against HCC cell lines. Antrocinol also substantially suppressed the expression of KRAS-GTP, p-MEK1/2, p-ERK1/2, and p-AKT in the Huh7 cell line. Additionally, antrocinol-induced apoptosis in the Huh7 cell line, inhibited the formation of tumorspheres, and suppressed the expression of cancer stem cell markers CD133, KLF4, CD44, OCT4, SOX2, and c-Myc. Animal studies revealed that antrocinol alone considerably suppressed tumor growth in nonobese diabetic/severe combined immunodeficient mice inoculated with Huh7 tumorspheres. It also synergistically enhanced the anticancer effect of sorafenib, resulting in enhanced suppression of tumor growth (p < 0.001) and tumorsphere formation (p < 0.001). In tumor samples resected from mice treated with antrocinol alone or in combination with sorafenib, immunohistochemical analysis revealed an increase in BAX expression and a decrease in ERK and AKT protein expression. To the best of our knowledge, this is the first report of the anti-HCC activity of antrocinol. With its higher therapeutic efficacy than that of sorafenib, antrocinol is a candidate drug for patients with HCC who demonstrate little or no response to sorafenib treatment. © 2022 Elsevier B.V.

关键词： Antrocinol Cancer stemness Hepatocellular carcinoma KRAS/AKT/ERK axis Sorafenib

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Dynamics of one-dimensional spin models via complex-time evolution of tensor networks

arXiv

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arXiv 2025年

作者： Cha, Jeong Hyeok Lee, Hyun-Yong Kim, Heung-Sik Department of Semiconductor Physics Kangwon National University Chuncheon24341 Korea Republic of Interdisciplinary Program in Earth Environmental System Science and Engineering Kangwon National University Chuncheon24341 Korea Republic of Division of Semiconductor Physics Korea University Sejong30019 Korea Republic of Department of Applied Physics Graduate School Korea University Sejong30019 Korea Republic of Institute of Quantum Convergence Technology Kangwon National University Chuncheon24341 Korea Republic of

Studying the real-time dynamics of strongly correlated systems poses significant challenges, which have recently become more manageable thanks to advances in density matrix renormalization group (DMRG) and tensor network methods. A notable development in this area is the introduction of a complex-time evolution scheme for tensor network states, originally suggested for solving Anderson impurity model and designed to suppress the growth of entanglement under time evolution. In this study, we employ the complex-time evolution scheme to investigate the dynamics of one-dimensional spin systems, specifically the transverse-field Ising model (TFIM) and the XXZ model. Our analysis revisits the dynamic critical exponent z of the TFIM and explores the dynamical structure factor in both gapped and gapless states of the XXZ model. Importantly, the complex-time evolution reproduces the results of real-time evolution while mitigating the rapid growth of quantum entanglement typically associated with the latter. These results demonstrate that the combination of complex-time evolution and extrapolation provides a robust and efficient framework for studying the dynamics of complex quantum systems, enabling more comprehensive insights into their behavior. © 2025, CC BY.

关键词： Quantum entanglement

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