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Incidence trends of oral cavity, oropharyngeal, hypopharyngeal and laryngeal cancers among males in Taiwan, 1980-2019: a population-based cancer registry study

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BMC cancer 2023年第1期23卷 213页

作者： Yu-Shiun Tsai Yong-Chen Chen Tzu-I Chen Yu-Kwang Lee Chun-Ju Chiang San-Lin You Wan-Lun Hsu Li-Jen Liao School of Medicine College of Medicine Fu-Jen Catholic University New Taipei City 242 Taiwan. Master Program of Big Data Analysis in Biomedicine College of Medicine Fu Jen Catholic University New Taipei City 242 Taiwan. Data Science Center College of Medicine Fu Jen Catholic University New Taipei City 242 Taiwan. Graduate Institute of Business Administration College of Management Fu Jen Catholic University New Taipei City 242062 Taiwan. Division of General Surgery Department of Surgery National Taiwan University Hospital Taipei 100 Taiwan. Graduate Institute of Epidemiology and Preventive Medicine College of Public Health National Taiwan University Taipei 10055 Taiwan. Master Program of Big Data Analysis in Biomedicine College of Medicine Fu Jen Catholic University New Taipei City 242 Taiwan. 156521@mail.fju.edu.tw. Data Science Center College of Medicine Fu Jen Catholic University New Taipei City 242 Taiwan. 156521@mail.fju.edu.tw. Otolaryngology Head and Neck Surgery Far Eastern Memorial Hospital No. 21 Sec. 2 Nanya S. Rd. Banciao Dist. New Taipei City 220 Taiwan. liaolj@ntu.edu.tw. Head and Neck Cancer Surveillance & Research Group Far Eastern Memorial Hospital New Taipei Taiwan. liaolj@ntu.edu.tw. Department of Electrical Engineering Yuan Ze University Taoyuan Taiwan. liaolj@ntu.edu.tw.

In a country with a high prevalence of cigarette smoking, betel chewing, and alcohol drinking, cancers of the oral cavity, nasopharynx, and larynx were the fourth, twelfth and seventeenth leading causes of cancer death, respectively, for men in 2020. We analyzed patients with head and neck cancer from 1980 to 2019 from the Taiwan Cancer Registration Database and discussed the annual average percent change, average percent change, age period, and birth cohort. Obvious period effects and birth effects are seen in oral, oropharyngeal, and hypopharyngeal cancer; however, the most significant period effect was seen between 1990 and 2009, which mainly reflects the consumption of betel nuts per capita. In addition, the period effect lessens after 2010 in oral cancer and hypopharyngeal cancers, while oropharyngeal cancers remain an obvious period effect, which results from the rising prevalence of HPV. Due to the high prevalence rate of betel quid chewing and cigarette smoking in the 1990s, the government executed several acts. As a result, the age-adjusted incidence rates of oral, oropharyngeal, and hypopharyngeal cancers have flattened since 2010, which can be explained by the declining cigarette smoking rate. The strict policy indeed shows an obvious effect on the head and neck cancer incidence rates, and we expect to see a further decline in the future.

关键词： Age-period-cohort effect Head and neck cancers Incidence Secular trend

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Surveillance of avian influenza through bird guano in remote regions of the global south to uncover transmission dynamics

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Nature communications 2025年第1期16卷 4900页

作者： Dhammika Leshan Wannigama Mohan Amarasiri Phatthranit Phattharapornjaroen Cameron Hurst Charin Modchang John Jefferson V Besa Kazuhiko Miyanaga Longzhu Cui Stefan Fernandez Angkana T Huang Puey Ounjai W K C P Werawatte Ali Hosseini Rad S M Porames Vatanaprasan Dylan John Jay Thammakorn Saethang Sirirat Luk-In Phitsanuruk Kanthawee Wanwara Thuptimdang Ratana Tacharoenmuang Bernadina Cynthia S P H Spencer Vitharana Natharin Ngamwongsatit Hitoshi Ishikawa Takashi Furukawa Yangzhong Wang Andrew C Singer Naveen Kumar Devanga Ragupathi Tanittha Chatsuwan Kazunari Sei Asuka Nanbo Asada Leelahavanichkul Talerngsak Kanjanabuch Hiroshi Hamamoto Paul G Higgins Daisuke Sano Anthony Kicic José O Valdebenito Jonas Bonnedahl Sam Trowsdale Parichart Hongsing Aisha Khatib Kenji Shibuya Shuichi Abe Department of Infectious Diseases Faculty of Medicine Yamagata University Yamagata Japan. leshanwannigama@med.id.yamagata-u.ac.jp. Department of Infectious Diseases and Infection Control Yamagata Prefectural Central Hospital Yamagata Japan. leshanwannigama@med.id.yamagata-u.ac.jp. Pathogen Hunter's Research Collaborative Team Department of Infectious Diseases and Infection Control Yamagata Prefectural Central Hospital Yamagata Japan. leshanwannigama@med.id.yamagata-u.ac.jp. Yamagata Prefectural University of Health Sciences Kamiyanagi Yamagata Japan. leshanwannigama@med.id.yamagata-u.ac.jp. The Lygodium Ceylon Health and Environmental Policy Research Center Colombo Sri Lanka. leshanwannigama@med.id.yamagata-u.ac.jp. Biofilms and Antimicrobial Resistance Consortium of ODA receiving countries The University of Sheffield Sheffield UK. leshanwannigama@med.id.yamagata-u.ac.jp. Pathogen Hunter's Research Collaborative Team Department of Infectious Diseases and Infection Control Yamagata Prefectural Central Hospital Yamagata Japan. Department of Civil and Environmental Engineering Graduate School of Engineering Tohoku University Sendai Miyagi Japan. Faculty of Health Science Technology Chulabhorn Royal Academy Bangkok Thailand. HRH Princess Chulabhorn Disaster and Emergency Medicine Center Chulabhorn Royal Academy Bangkok Thailand. Department of Clinical Epidemiology Faculty of Medicine Thammasat University Rangsit Thailand. Center of Excellence in Applied Epidemiology Thammasat University Rangsit Thailand. Mater Research Institute University of Queensland Brisbane QLD Australia. Biophysics Group Department of Physics Faculty of Science Mahidol University Bangkok Thailand. Centre of Excellence in Mathematics MHESI Bangkok Thailand. Thailand Center of Excellence in Physics Ministry of Higher Education Science Research and Innovation Bangkok Thailand. Department of Infectious Diseases and Infection Control Yamagata Prefectural Central Hospital Yamagata Japan. Co

Avian influenza viruses (AIVs) pose a growing global health threat, particularly in low- and middle-income countries (LMICs), where limited surveillance capacity and under-resourced healthcare systems hinder timely detection and response. Migratory birds play a significant role in the transboundary spread of AIVs, yet data from key regions along migratory flyways remain sparse. To address these surveillance gaps, we conducted a study between December 2021 and February 2023 using fresh bird guano collected across 10 countries in the Global South. Here, we show that remote, uninhabited regions in previously unsampled areas harbor a high diversity of AIV strains, with H5N1 emerging as the most prevalent. Some of these H5N1 samples also carry mutations that may make them less responsive to the antiviral drug oseltamivir. Our findings documented the presence of AIVs in several underrepresented regions and highlighted critical transmission hotspots where viral evolution may be accelerating. These results underscore the urgent need for geographically targeted surveillance to detect emerging variants, inform public health interventions, and reduce the risk of zoonotic spillover.

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Patterns of somatic structural variation in human cancer genomes (vol 578, pg 112, 2020)

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NATURE 2023年第7948期614卷 E38-E38页

作者： Li, Yilong Roberts, Nicola D. Wala, Jeremiah A. Shapira, Ofer Schumacher, Steven E. Kumar, Kiran Khurana, Ekta Waszak, Sebastian Korbel, Jan O. Haber, James E. Imielinski, Marcin Weischenfeldt, Joachim Beroukhim, Rameen Campbell, Peter J. Cancer Genome Project Wellcome Trust Sanger Institute Hinxton UK Totient Inc Cambridge MA USA Wellcome Sanger Institute Wellcome Genome Campus Hinxton UK Department of Haematology University of Cambridge Cambridge UK Cambridge University Hospitals NHS Foundation Trust Cambridge UK Korea Advanced Institute of Science and Technology Daejeon South Korea Department of Zoology Genetics and Physical Anthropology University of Santiago de Compostela Santiago de Compostela Spain Centre for Research in Molecular Medicine and Chronic Diseases (CIMUS) University of Santiago de Compostela Santiago de Compostela Spain The Biomedical Research Centre (CINBIO) University of Vigo Vigo Spain Centre for Research in Molecular Medicine and Chronic Diseases (CiMUS) Universidade de Santiago de Compostela Santiago de Compostela Spain Department of Zoology Genetics and Physical Anthropology (CiMUS) Universidade de Santiago de Compostela Santiago de Compostela Spain The Biomedical Research Centre (CINBIO) Universidade de Vigo Vigo Spain The Broad Institute of Harvard and MIT Cambridge MA USA Bioinformatics and Integrative Genomics Harvard University Cambridge MA USA Department of Cancer Biology Dana-Farber Cancer Institute Boston MA USA Broad Institute of MIT and Harvard Cambridge MA USA Department of Medical Oncology Dana-Farber Cancer Institute Boston MA USA Harvard Medical School Boston MA USA Massachusetts General Hospital Center for Cancer Research Charlestown MA USA Dana-Farber Cancer Institute Boston MA USA Department of Biostatistics and Computational Biology Dana-Farber Cancer Institute and Harvard Medical School Boston MA USA Weill Cornell Medical College New York NY USA Department of Physiology and Biophysics Weill Cornell Medicine New York NY USA Institute for Computational Biomedicine Weill Cornell Medicine New York NY USA Controlled Department and Institution New York NY USA Englander Institute for Precision Medicine Weill Cornell Medicine Ne

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Global tracking of marine megafauna space use reveals how to achieve conservation targets

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science (New York, N.Y.) 2025年第6751期388卷 1086-1097页

作者： Ana M M Sequeira Jorge P Rodríguez Sarah A Marley Hannah J Calich Mirjam van der Mheen Michelle VanCompernolle Lucy M Arrowsmith Lauren R Peel Nuno Queiroz Marisa Vedor Ivo da Costa Gonzalo Mucientes Ana Couto Nicolas E Humphries Sara Abalo-Morla Francisco J Abascal Debra L Abercrombie Katya Abrantes F Alberto Abreu-Grobois André S Afonso Pedro Afonso Heidi Ahonen Susanne Åkesson Joanna Alfaro-Shigueto Russel D Andrews Frédéric Angelier Marina Antonopoulou Javier A Arata Gonzalo Araujo Randall Arauz José Manuel Arcos Igor Arregui Haritz Arrizabalaga Marie Auger-Méthé Steffen Bach Fred Bailleul Robin W Baird George H Balazs Susan G Barco Adam Barnett Warren Baverstock Alastair M M Baylis Annalea Beard Juan Bécares Eduardo J Belda Ian Bell Ashley Bennison Scott R Benson Diego Bernal Michael L Berumen Sandra Bessudo Natalia P A Bezerra Antonin V Blaison Gabriela S Blanco Barbara A Block Mark Bolton Mark E Bond Ramón Bonfil Camrin D Braun Annette C Broderick Michael de L Brooke Annabelle M L Brooks Edward J Brooks Ignacio M Bruno Jennifer M Burns Michael E Byrne Steven E Campana Hamish A Campbell Richard A Campbell Aaron Carlisle Ruth H Carmichael Gemma Carroll Paolo Casale Filipe R Ceia Demian D Chapman Taylor K Chapple Jean-Benoit Charrassin Andre Chiaradia John Chisholm Christopher R Clarke Thomas A Clay Christophe Cleguer Elizabeth Clingham Eric E G Clua Jesse E M Cochran Rochelle Constantine Robert W Cooper Estelle Crochelet Michelle Cronin Eduardo Cuevas Kayla P DaCosta Laurent Dagorn Ryan Daly Randall W Davis P J Nico de Bruyn Carlos Delgado-Trejo Thomas Dellinger Solène Derville Stella Diamant Andrew DiMatteo Kara L Dodge Philip D Doherty Michael C Double Alistair D M Dove Thomas K Doyle Michael J Drew Lindsay L Dubbs Clinton A J Duffy Peter H Dutton Ewan W J Edwards Luke D Einoder Mark V Erdmann Eduardo Espinoza Nicole Esteban Ana Isabel Fagundes Chris Feare Steven H Ferguson Luciana C Ferreira Francesco Ferretti John Filmalter Brittany Finucci G Chris Fischer Richard J Fitzpatrick Jorge Fontes Angela Formia Division of Ecology and Evolution Research School of Biology The Australian National University Canberra (Australian Capital Territory) Australia. UWA Oceans Institute and the School of Biological Sciences The University of Western Australia Perth (Western Australia) Australia. Instituto de Física Interdisciplinar y Sistemas Complejos (IFISC) CSIC-UIB Palma de Mallorca Spain. Instituto Mediterráneo de Estudios Avanzados (IMEDEA) CSIC-UIB Esporles Illes Balears Spain. C.A. Illes Balears Universidad Nacional de Educación a Distancia (UNED) Palma Spain. Delegación Territorial en Illes Balears Agencia Estatal de Meteorología (AEMET) Muelle de Poniente s/n Palma Spain. Scotland's Rural College (SRUC) Craibstone Estate Bucksburn Aberdeen UK. Oceans Graduate School and the UWA Oceans Institute The University of Western Australia Perth (Western Australia) Australia. School of Engineering and the UWA Oceans Institute The University of Western Australia Perth (Western Australia) Australia. Department of Biodiversity Conservation and Attractions Biodiversity and Conservation Science Kensington (Western Australia) Australia. Save Our Seas Foundation Geneva Switzerland. The Manta Trust Catemwood House Norwood Lane Corscombe Dorset UK. Centro de Investigação em Biodiversidade e Recursos Genéticos (CIBIO) InBIO Laboratório Associado Campus de Vairão Universidade do Porto Vairão Portugal. BIOPOLIS Program in Genomics Biodiversity and Land Planning Campus de Vairao Vairão Portugal. Instituto de Investigaciones Marinas Consejo Superior de Investigaciones Científicas (IIM-CSIC) Vigo Pontevedra Spain. School of Biological Sciences University of Aberdeen Aberdeen UK. Biomathematics and statistics Scotland The kings building Edinburgh Scotland. Marine Biological Association (MBA) The Laboratory Citadel Hill Plymouth UK. Instituto de Investigación para la Gestión Integrada de Zonas Costeras Universitat Politècnica de València Gandia València Spain. Instituto Español de O

The recent Kunming-Montreal Global Biodiversity Framework (GBF) sets ambitious goals but no clear pathway for how zero loss of important biodiversity areas and halting human-induced extinction of threatened species will be achieved. We assembled a multi-taxa tracking dataset (11 million geopositions from 15,845 tracked individuals across 121 species) to provide a global assessment of space use of highly mobile marine megafauna, showing that 63% of the area that they cover is used 80% of the time as important migratory corridors or residence areas. The GBF 30% threshold (Target 3) will be insufficient for marine megafauna's effective conservation, leaving important areas exposed to major anthropogenic threats. Coupling area protection with mitigation strategies (e.g., fishing regulation, wildlife-traffic separation) will be essential to reach international goals and conserve biodiversity.

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Scaffold-free tissue engineering for injured joint surface restoration

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Journal of Experimental Orthopaedics 2018年第1期5卷 2页

作者： Shimomura, Kazunori Ando, Wataru Fujie, Hiromichi Hart, David A. Yoshikawa, Hideki Nakamura, Norimasa Medicine for Sports and Performing Arts Department of Health and Sport Sciences Osaka University Graduate School of Medicine 2-2 Yamadaoka Suita City 565-0871 Osaka Japan Department of Orthopaedic Surgery Osaka University Graduate School of Medicine 2-2 Yamadaoka Suita City 565-0871 Osaka Japan Division of Human Mechatronics Systems Faculty of System Design Tokyo Metropolitan University 6-6 Asahigaoka Hino City 191-0065 Tokyo Japan McCaig Institute for Bone & Joint Health University of Calgary 3330 Hospital Drive Northwest Calgary T2N 4N1 AB Canada Institute for Medical Science in Sports Osaka Health Science University 1-9-27 Tenma Kita-ku Osaka City 530-0043 Osaka Japan Center for Advanced Medical Engineering and Informatics Osaka University 2-2 Yamadaoka Suita City 565-0871 Osaka Japan

Articular cartilage does not heal spontaneously due to its limited healing capacity, and thus effective treatments for cartilage injuries has remained challenging. Since the first report by Brittberg et al. in 1994, autologous chondrocyte implantation (ACI) has been introduced into the clinic. Recently, as an alternative for chondrocyte-based therapy, mesenchymal stem cell (MSC)-based therapy has received considerable research attention because of the relative ease in handling for tissue harvest, and subsequent cell expansion and differentiation. In this review, we discuss the latest developments regarding stem cell-based therapies for cartilage repair, with special focus on recent scaffold-free approaches. © 2018, The Author(s).

关键词： Cartilage repair Mesenchymal stem cell Scaffold-free

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Retracted: LUC Algorithm in Visual Cryptography

Retracted: LUC Algorithm in Visual Cryptography

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2018 Workshop on Multidisciplinary and Its Applications: Applied Mathematics, Computer science, Information systems, and Information Technology, WMA-Mathcomtech 2018

作者： Achmad Daengs, G.S. Ratnadewi Alpha, Christian Dio Napitupulu, Darmawan Nurdiyanto, Heri Kurniasih, Nuning Hasibuan, Abdurrozaq Daengs, Achmad Manurung, Rosida Tiurma Mulyaningsih, Indrya Rahim, Robbi Sugianto, Castaka Agus Abdullah, Dahlan Department of Electrical Engineering Universitas Kristen Maranatha Bandung Indonesia Research Center for Quality System and Testing Technology Indonesian Institute of Sciences Banten Indonesia STMIK Dharma Wacana Indonesia Faculty of Communication Sciences Library and Information Science Program Universitas Padjadjaran Bandung Indonesia Universitas Islam Sumatera Utara Indonesia University of 45 Surabaya Indonesia Graduate Program in Scientific Psychology Universitas Kristen Maranatha Bandung Indonesia Department of Education Institut Agama Islam Negeri Syekh Nurjati Cirebon Indonesia School of Computer and Communication Engineering Universiti Malaysia Perlis Kubang Gajah Malaysia Politeknik TEDC Bandung Indonesia Department of Informatics Universitas Malikussaleh Aceh Utara Indonesia

Nowadays, messaging technology in digital data form more often used and not less messages that confidentially wanted. Then it should be modified so that can be understood only by the sender and the intended recipients. All of this system can be realization by using cryptography. LUC algorithms are introduced by Smith and Lennon in 1993. LUC algorithm is an algorithm that based on the use of Lucas sequence (specific arithmetic operations derived from Lucas row) that rarely used to enhance the security of the messages. In this research, LUC algorithm is combined with visual cryptography to process the encryption and the description of a colored image. Four different images were used in the trial here. The performance of the system is assessed using Structural similarity (SSIM) which has an assessment similar to human eye. If the image quality is the same as the original image, then the SSIM value is one. Whereas if the quality of decryption image is very different from the original image then the value of SSIM is zero. © Published under licence by IOP Publishing Ltd.

关键词： Information systems

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Identification of gene expression signatures for psoriasis classification using machine learning techniques

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Medicine in Omics 2021年 1卷

作者： Nguyen Quoc Khanh Le Duyen Thi Do Trinh-Trung-Duong Nguyen Ngan Thi Kim Nguyen Truong Nguyen Khanh Hung Nguyen Thi Thu Trang Professional Master Program in Artificial Intelligence in Medicine College of Medicine Taipei Medical University Taipei City 106 Taiwan Research Center for Artificial Intelligence in Medicine Taipei Medical University Taipei City 106 Taiwan Graduate Institute of Biomedical Informatics Taipei Medical University Taipei City 106 Taiwan Department of Computer Science and Engineering Yuan Ze University Chung-Li 32003 Taiwan School of Nutrition and Health Sciences Taipei Medical University Taipei City 110 Taiwan International Master/Ph.D. Program in Medicine College of Medicine Taipei Medical University Taipei City 110 Taiwan Orthopedic and Trauma Department Cho Ray Hospital Ho Chi Minh City Viet Nam International PhD Program for Cell Therapy and Regeneration Medicine College of Medicine Taipei Medical University Taipei City 110 Taiwan

Psoriasis classification requires the accurate identification of the lesional types for the early and effective diagnosis and it is worth interesting that the normal and psoriasis cell tissues exhibit different gene expression. Therefore, gene expression data is an effective source for psoriasis classification and there is a challenge regarding the selection of suitable gene signatures for its purpose. In this present study, the gene expression-based microarray data were used and 35 expression features linked with psoriasis were utilized to feed into our machine learning model. Overall, the performance of our model based on 35 mentioned-above features surpassed that of other state-of-the-art classifiers with an average accuracy of 98.3%, recall of 98.6%, and precision of 98% in 5-fold cross-validation tests. We also validate our model on two different sets of psoriasis and the performance results are significant. These results have suggested that our 35 expression signatures have been identified as key features for classifying samples between lesion and non-lesion. More specifically, the expression levels of few genes i.e., FABP5 , TGM1 , or BCAR3 are discovered as newly potential biomarkers for psoriasis classification and treatment with high confidence. This study, therefore, could shed light on developing the prediction models for psoriasis classification and treatment using gene expression profiles.

关键词： Psoriasis classification Random forest Gene expression Feature selection Machine learning FABP5 Dermatology

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Genome-wide association study of long COVID

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Nature Genetics 2025年 1-16页

作者： Lammi, Vilma Nakanishi, Tomoko Jones, Samuel E. Andrews, Shea J. Karjalainen, Juha Cortés, Beatriz O’Brien, Heath E. Ochoa-Guzman, Ana Fulton-Howard, Brian E. Broberg, Martin Haapaniemi, Hele H. Kanai, Masahiro Pirinen, Matti Schmidt, Axel Mitchell, Ruth E. Mousas, Abdou Mangino, Massimo Huerta-Chagoya, Alicia Sinnott-Armstrong, Nasa Cirulli, Elizabeth T. Vaudel, Marc Kwong, Alex S. F. Maiti, Amit K. Marttila, Minttu M. Posner, Daniel C. Rodriguez, Alexis A. Batini, Chiara Minnai, Francesca Dearman, Anna R. Warmerdam, C. A. Robert Sequeros, Celia B. Winkler, Thomas W. Jordan, Daniel M. Rešcenko, Raimonds Miano, Lorenzo Lane, Jacqueline M. Chung, Ryan K. Guillen-Guio, Beatriz Leavy, Olivia C. Carvajal-Silva, Laura Aguilar-Valdés, Kevin Frangione, Erika Guare, Lindsay Vergasova, Ekaterina Marouli, Eirini Striano, Pasquale Zainulabid, Ummu Afeera Kumar, Ashutosh Ahmad, Hajar Fauzan Edahiro, Ryuya Azekawa, Shuhei Maj, Carlo Pensel, Max C. Miller, Abigail Nöthen, Markus M. Behzad, Pari Schultz, Sonja Heggemann, Julia Balla, Daniella Morrison, David R. Mooser, Vincent Perley, Danielle Ragoussis, Jiannis Rousseau, Simon Shi, Fangyi Lathrop, G. Mark Yanishevsky, Solomia Laurent, Laetitia Auld, Daniel Bertrand, Mylene Boisclair, Ariane Bourque, Guillaume Bujold, David Durand, Madeleine Adra, Darin St-Cyr, Janick Niemi, Mari E. K. Iyengar, Sudha K. Cai, Tianxi Cho, Kelly Sarvadhavabhatla, Sannidhi Donaire, Maria Sophia Valenzuela-Jorquera, Héctor Lamoza, Eduardo Arévalo, Tamara V. Retamales-Ortega, Rocío Sanhueza, Sergio Selman, Carolina S. Silva, Andrea X. Alarcon, Teresa A. Martínez, Matías F. Quiroga, Romina Zuñiga-Pacheco, Paula Zapata-Contreras, Daniela Yáñez, Cristian E. Quiñones, Luis A. Tobar-Calfucoy, Eduardo A. Monardes-Ramírez, Virginia A. Signore, Iskra A. Guajardo, Lissette G. Figueroa, Alvaro Oróstica, Karen Y. Muñoz, Christian A. Fuentes-Guajardo, Macarena Bocchieri, Pamela Cabrera, Camilo Echeverria, Cesar A. Cerpa, Leslie C. Donoso, Gerardo Gutiérrez-Richards, Scarlett Nova-Lamperti, Estefania Saez Hidalgo Institute for Molecular Medicine Finland (FIMM) Helsinki Institute of Life Science (HiLIFE) University of Helsinki Helsinki Finland Department of Human Genetics McGill University Montreal QC Canada Centre for Clinical Epidemiology Department of Medicine Lady Davis Institute Jewish General Hospital McGill University Montreal QC Canada Kyoto-McGill International Collaborative Program in Genomic Medicine Graduate School of Medicine Kyoto University Kyoto Japan Department of Genome Informatics Graduate School of Medicine the University of Tokyo Tokyo Japan Research Fellow Japan Society for the Promotion of Science Tokyo Japan Department of Psychiatry and Behavioral Sciences University of California San Francisco San Francisco CA United States Program in Medical and Population Genetics Broad Institute of Harvard and MIT Cambridge MA United States Stanley Center for Psychiatric Research Broad Institute of Harvard and MIT Cambridge MA United States Analytic and Translational Genetics Unit Massachusetts General Hospital Boston MA United States Genomes for Life-GCAT Lab CORE Program Germans Trias i Pujol Research Institute (IGTP) Badalona Spain Grup de REcerca en Impacte de les Malalties Cròniques i les seves Trajectòries (GRIMTra) Barcelona Spain Sano Genetics Limited London United Kingdom Unidad de Biología Molecular y Medicina Genómica Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán Mexico City Mexico Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai New York City NY United States Broad Institute Cambridge MA United States Analytical and Translational Genetics Unit Massachusetts General Hospital Harvard Medical School Boston MA United States Department of Mathematics and Statistics University of Helsinki Helsinki Finland Department of Public Health University of Helsinki Helsinki Finland Institute of Human Genetics University of Bonn School of Medicine and University Hospital Bonn Bonn Germany MRC Integrat

Infections can lead to persistent symptoms and diseases such as shingles after varicella zoster or rheumatic fever after streptococcal infections. Similarly, severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) infection can result in long coronavirus disease (COVID), typically manifesting as fatigue, pulmonary symptoms and cognitive dysfunction. The biological mechanisms behind long COVID remain unclear. We performed a genome-wide association study for long COVID including up to 6,450 long COVID cases and 1,093,995 population controls from 24 studies across 16 countries. We discovered an association of FOXP4 with long COVID, independent of its previously identified association with severe COVID-19. The signal was replicated in 9,500 long COVID cases and 798,835 population controls. Given the transcription factor FOXP4’s role in lung physiology and pathology, our findings highlight the importance of lung function in the pathophysiology of long COVID. © The Author(s) 2025.

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Effect of low oxygen conditions on matrix metalloproteinase-9 production of macrophages subjected to cyclic stretching: Involvement of ERK and Rho kinase pathways

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Journal of Biomechanical science and engineering 2017年第1期12卷 16-00590-16-00590页

作者： Sakamoto, Naoya Sadamoto, Kiyomi Department of Intelligent Mechanical Systems Graduate School of System Design Tokyo Metropolitan University 6-6 Asahigaoka Hino Tokyo191-0065 Japan Department of Medical Engineering Faculty of Health Science and Technology Kawasaki University of Medical Welfare 288 Matsushima Kurashiki Okayama701-0193 Japan

Macrophages infiltrated in the walls of abdominal aortic aneurysms (AAA) are subjected to cyclic stretching due to pulsatile deformation of blood vessels and low oxygen conditions caused by intraluminal thrombus. These conditions could induce aberrant changes in macrophage functions and lead local weakening of AAA walls. We previously reported that the combination of 10 % cyclic stretching and 2.2% O2 conditions caused an increase in matrix metalloproteinase-9 (MMP-9) production in macrophages as well as changes in morphological responses to cyclic stretching. In the present study, we investigated the effects of oxygen concentrations on MMP-9 productions and morphological changes of macrophages subjected to cyclic stretching. Macrophages differentiated from THP-1 cells were subjected to 10% cyclic stretching under 5% or 1% O2 conditions for 24 h, and gelatinolytic activity of MMP-9 in the conditioned medium was assessed by zymography. Cells showed spread and rounded shape under static conditions and elongated and oriented to the direction of stretching after exposure to cyclic stretching, and there were no obvious effects of oxygen concentrations in cell morphology. An O2 concentration of 5% did not change MMP-9 productions of macrophages in static culture and subjected to cyclic stretching compared to normal cell culture condition of 20% O2. In contrast, 1% O2 condition stimulated MMP-9 production of macrophages both under static culture and cyclic stretching conditions. We also found that treatments of inhibitors for extracellular signal-regulated kinase (ERK) and Rho associated protein kinase (Rho kinase) suppressed the increased MMP-9 productions of macrophages by 1% O2 condition. These results suggest that lower oxygen conditions such as 1% O2 stimulate MMP-9 production in macrophages through signaling pathways involving ERK as well as Rho kinase-mediated actin cytoskeletal contractility. © 2017 The Japan Society of Mechanical Engineers.

关键词： Macrophages

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Fluorescent phenylthiazoles: Application as latent fingermark and their cytotoxicity against NOK-SI cell line

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Chemical Data Collections 2021年 33卷

作者： Bruno Nunes da Rosa Kristiane de Cássia Mariotti Bruna Silveira Pacheco Caroline Carapina da Silva Neftalí Lenin Villarreal Carreño Caroline Nicolodi Tais Poletti Allison Carlos Assunção Silva Adriana Fernandes da Silva Janice Luehring Giongo Rodrigo de Almeida Vaucher Tiago Franco de Oliveira Claudio Martin Pereira de Pereira Laboratory of Lipidomics and Bioorganic Bioforensics Research Group Federal University of Pelotas 96010 900 Pelotas RS Brazil National Institute of Forensic Science and Technology (INCT Forensic) Porto Alegre (RS) Pelotas (RS) Brazil Identification Group Brazilian Federal Police 90610-093 Porto Alegre RS Brazil Materials Science and Engineering Technology Development Center Federal University of Pelotas 96010-000 Pelotas RS Brazil Post-Graduate Program in Dentistry Department of Restorative Dentistry Dental School Federal University of Pelotas 96010 Pelotas RS Brazil Laboratory of Biochemistry Research and Molecular Biology of Microorganisms (LaPeBBiOM) Federal University of Pelotas 96010-900 Pelotas RS Brazil Pharmacosciences Department Federal University of Health Sciences of Porto Alegre Porto Alegre RS Brazil

Fingerprints are unique to each individual who contributes to human identification in forensic cases. In this sense, the present work aimed to synthesize 1H-pyrazol-1-yl-4-phenylthiazoles and apply them as powder agents to reveal latent finger marks as an alternative and low cost related to powders found on the market. The compounds were characterized by infrared; fluorescence; 1H NMR; 13C NMR; laser diffractometer and SEM. In addition, cytotoxicity was also evaluated in oral keratinocytes showing high cell viability. The result of the hemolytic assay revealed that compound 2a does not present red cell cytotoxicity. The prepared powders were applied to fingermarks deposited on different surfaces providing quality visualization at level three so that human identification is possible.

关键词： Forensic chemistry Fingermark Thiazoles Cytotoxicity Development powder

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