检索结果-内蒙古大学图书馆

SSRN 2020年

作者： Grasso, Michael Bond, Gavin J. Kim, Ye-Jin Alwan, Katherine B. Boyd, Stefanie Dzebo, Maria Matson Valenzuela, Sebastian Tsang, Tiffany Schibrowsky, Natalie A. Matthews, Megan L. Burslem, George M. Wittung-Stafshede, Pernilla Winkler, Duane D. Blackburn, Ninian J. Marmorstein, Ronen Brady, Donita C. Department of Chemistry School of Arts and Sciences University of Pennsylvania PhiladelphiaPA19104 United States Abramson Family Cancer Research Institute Perelman School of Medicine University of Pennsylvania PhiladelphiaPA19104 United States Biochemistry Major Program College of Arts and Sciences University of Pennsylvania PhiladelphiaPA19104 United States Department of Cancer Biology Perelman School of Medicine University of Pennsylvania PhiladelphiaPA19104 United States Department of Chemical Physiology and Biochemistry School of Medicine Oregon Health and Science University PortlandOR97239 United States Department of Biological Sciences University of Texas at Dallas RichardsonTX75080 United States Department of Biology and Biological Engineering Chalmers University of Technology Gothenburg412 96 Sweden Cell and Molecular Biology Graduate Group Perelman School of Medicine University of Pennsylvania PhiladelphiaPA19104 United States Department of Biochemistry and Molecular Biophysics Perelman School of Medicine University of Pennsylvania PhiladelphiaPA19104 United States

Normal physiology relies on the precise coordination of intracellular signal transduction pathways that respond to nutrient availability to balance cell growth and cell death. We recently established a critical mechanistic function for the redox-active micronutrient copper (Cu) in the canonical mitogen activated protein kinase (MAPK) pathway at the level of MEK1 and MEK2. Here we report the X-ray crystal structure of Cu-MEK1 and reveal active site chemical ligands and oxidation state specificity for MEK1 Cu coordination. Mechanistically, the Cu chaperone CCS selectively bound to and facilitated Cu transfer to MEK1. Mutations in MEK1 that disrupt Cu(I) affinity or a CCS small molecule inhibitor reduced Cu-stimulated MEK1 kinase activity. These atomic and molecular level data provide the first mechanistic insights of Cu kinase signaling and could be exploited for the development of novel MEK1/2 inhibitors that either target the Cu structural interface or blunt dedicated Cu delivery mechanisms via CCS. © 2020, The Authors. All rights reserved.

关键词： Cell death

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Data-augmented modeling of intracranial pressure

arXiv

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arXiv 2018年

作者： Wang, Jian-Xun Hu, Xiao Shadden, Shawn C. Mechanical Engineering University of California BerkeleyCA United States Aerospace and Mechanical Engineering Center of Informatics and Computational Science University of Notre Dame Notre DameIN United States Department of Physiological Nursing Department of Neurological surgery Institute of Computational Health Sciences UCSF Joint Bio-Engineering Graduate Program University of California San FranciscoCA United States

Precise management of patients with cerebral diseases often requires intracranial pressure (ICP) monitoring, which is highly invasive and requires a specialized ICU setting. The ability to noninvasively estimate ICP is highly compelling as an alternative to, or screening for, invasive ICP measurement. Most existing approaches for noninvasive ICP estimation aim to build a regression function that maps noninvasive measurements to an ICP estimate using statistical learning techniques. These data-based approaches have met limited success, likely because the amount of training data needed is onerous for this complex applications. In this work, we discuss an alternative strategy that aims to better utilize noninvasive measurement data by leveraging mechanistic understanding of physiology. Specifically, we developed a Bayesian framework that combines a multiscale model of intracranial physiology with noninvasive measurements of cerebral blood flow using transcranial Doppler. Virtual experiments with synthetic data are conducted to verify and analyze the proposed framework. A preliminary clinical application study on two patients is also performed in which we demonstrate the ability of this method to improve ICP prediction. Copyright © 2018, The Authors. All rights reserved.

关键词： Diagnosis

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Ovatodiolide and antrocin synergistically inhibit the stemness and metastatic potential of hepatocellular carcinoma via impairing ribosome biogenesis and modulating ERK/Akt-mTOR signaling axis

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Phytomedicine : international journal of phytotherapy and phytopharmacology 2023年 108卷 154478页

作者： Ming-Yao Chen Chia-Hung Hsu Syahru Agung Setiawan David T W Tzeng Hon-Ping Ma Jiann Ruey Ong Yi Cheng Chu Ming-Shou Hsieh Alexander T H Wu Yew-Min Tzeng Chi-Tai Yeh Division of Gastroenterology and Hepatology Department of Internal Medicine School of Medicine College of Medicine Taipei Medical University Taipei City 110 Taiwan Division of Gastroenterology and Hepatology Department of Internal Medicine Taipei Medical University-Shuang Ho Hospital New Taipei City 235 Taiwan. Department of Emergency Medicine Taipei Medical University-Shuang Ho Hospital New Taipei City 235 Taiwan Graduate Institute of Injury Prevention and Control College of Public Health Taipei Medical University Taipei City 110 Taiwan Department of Emergency Medicine School of Medicine Taipei Medical University Taipei City 110 Taiwan. International Ph.D. Program in Medicine College of Medicine Taipei Medical University Taipei City 110 Taiwan Department of Medical Research & Education Taipei Medical University - Shuang-Ho Hospital New Taipei City 235 Taiwan. School of Life Sciences The Chinese University of Hong Kong Hong Kong SAR 999077 China Lifebit Mindspace Shoreditch London England EC2A 2AP UK. Department of Medicine St. George's University School of Medicine St. George Grenada. Department of Applied Science National Taitung University Taitung 95092 Taiwan. Electronic address: ymtzeng@nttu.edu.tw. Department of Medical Research & Education Taipei Medical University - Shuang-Ho Hospital New Taipei City 235 Taiwan Continuing Education Program of Food Biotechnology Applications College of Science and Engineering National Taitung University Taitung 95092 Taiwan. Electronic address: ctyeh@s.tmu.edu.tw.

Activation of mitogen-activated protein kinase (MAPK) and PI3K signaling confers resistance against sorafenib, a mainstay treatment for advanced hepatocellular carcinoma (HCC). Antrocin and ovatodiolide constitute as the most potent secondary metabolites isolated from Antrodia camphorata and Anisomeles indica, respectively. Both natural compounds have recently gained a lot of attention due to their putative inhibition of MAPK and PI3K signaling in various solid cancers. However, whether their combination is effective in HCC remains unknown. Here, we investigated their effect, alone or in various combinations, on MAPK and PI3K signaling pathways in HCC cells. An array of in vitro study were used to investigate anticancer and stemness effects to treat HCC, such as cytotoxicity, drug combination index, migration, invasion, colony formation, and tumor sphere formation. Drug effect in vivo was evaluated using mouse xenograft models. In this study, antrocin and ovatodiolide synergistically inhibited the SNU387, Hep3B, Mahlavu, and Huh7 cell lines. Sequential combination treatment of Huh7 and Mahlavu with ovatodiolide followed by antrocin resulted stronger cytotoxic effect than did treatment with antrocin followed by ovatodiolide, their simultaneous administration, antrocin alone, or ovatodiolide alone. In the Huh7 and Mahlavu cell lines, ovatodiolide→antrocin significantly suppressed colony formation and proliferation as well as markedly downregulated ERK1/2, Akt, and mTOR expression. Inhibition of ERK1/2 and Akt/mTOR signaling by ovatodiolide→antrocin suppressed ribosomal biogenesis, autophagy, and cancer stem cell-like phenotypes and promoted apoptosis in Huh7 and Mahlavu cells. The sorafenib-resistant clone of Huh7 was effectively inhibited by synergistic combination of both compound in vitro. Eventually, the ovatodiolide→antrocin combination synergistically suppressed the growth of HCC xenografts. Taken together, our findings suggested that ovatodiolide→antrocin combi

关键词： Advanced HCC Antrocin (ANC) MAPK Ovatodiolide (OVA) PI3K

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The electroencephalography protocol for the Accelerating Medicines Partnership® Schizophrenia program: Reliability and stability of measures

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Schizophrenia (Heidelberg, Germany) 2025年第1期11卷 85页

作者： Daniel H Mathalon Spero Nicholas Brian J Roach Tashrif Billah Suzie Lavoie Thomas Whitford Holly K Hamilton Lauren Addamo Andrey Anohkin Tristan Bekinschtein Aysenil Belger Kate Buccilli John Cahill Ricardo E Carrión Stefano Damiani Ilvana Dzafic Bjørn H Ebdrup Igor Izyurov Johanna Jarcho Raoul Jenni Anna Jo Sarah Kerins Clarice Lee Elizabeth A Martin Rocio Mayol-Troncoso Margaret A Niznikiewicz Muhammad Parvaz Oliver Pogarell Julio Prieto-Montalvo Rachel Rabin David R Roalf Jack Rogers Dean F Salisbury Riaz Shaik Stewart Shankman Michael C Stevens Yi Nam Suen Nicole C Swann Xiaochen Tang Judy L Thompson Ivy Tso Julian Wenzel Juan Helen Zhou Jean Addington Luis Alameda Celso Arango Nicholas J K Breitborde Matthew R Broome Kristin S Cadenhead Monica E Calkins Rolando I Castillo-Passi Eric Yu Hai Chen Jimmy Choi Philippe Conus Cheryl M Corcoran Barbara A Cornblatt Covadonga M Diaz-Caneja Lauren M Ellman Paolo Fusar-Poli Pablo A Gaspar Carla Gerber Louise Birkedal Glenthøj Leslie E Horton Christy Lai Ming Hui Joseph Kambeitz Lana Kambeitz-Ilankovic Matcheri S Keshavan Minah Kim Sung-Wan Kim Nikolaos Koutsouleris Jun Soo Kwon Kerstin Langbein Daniel Mamah Vijay A Mittal Merete Nordentoft Godfrey D Pearlson Jesus Perez Diana O Perkins Albert R Powers Fred W Sabb Jason Schiffman Jai L Shah Steven M Silverstein Stefan Smesny William S Stone Gregory P Strauss Rachel Upthegrove Swapna K Verma Jijun Wang Daniel H Wolf Tianhong Zhang Sylvain Bouix Ofer Pasternak Kang-Ik K Cho Michael J Coleman Dominic Dwyer Angela Nunez Zailyn Tamayo Stephen J Wood Rene S Kahn John M Kane Patrick D McGorry Carrie E Bearden Barnaby Nelson Scott W Woods Martha E Shenton Gregory A Light Department of Psychiatry and Behavioral Sciences and Weill Institute for Neurosciences University of California San Francisco San Francisco CA USA. daniel.mathalon@ucsf.edu. Mental Health Service Veterans Affairs San Francisco Health Care System San Francisco CA USA. daniel.mathalon@ucsf.edu. Mental Health Service Veterans Affairs San Francisco Health Care System San Francisco CA USA. Northern California Institute for Research and Education San Francisco CA USA. Department of Psychiatry Brigham and Women's Hospital and Harvard Medical School Boston MA USA. Orygen Parkville VIC Australia. Centre for Youth Mental Health The University of Melbourne Parkville VIC Australia. School of Psychology University of New South Wales (UNSW) Kensington NSW Australia. Department of Psychiatry and Behavioral Sciences and Weill Institute for Neurosciences University of California San Francisco San Francisco CA USA. University of Minnesota Minneapolis MN USA. Washington University School of Medicine St. Louis MO USA. Consciousness and Cognition Lab Department of Psychology University of Cambridge Cambridge UK. Department of Psychiatry University of North Carolina at Chapel Hill Chapel Hill NC USA. UNC Intellectual and Developmental Disabilities Research Center Carrboro NC USA. Department of Psychiatry Yale University School of Medicine New Haven CT USA. Department of Psychiatry Donald and Barbara Zucker School of Medicine at Hofstra/Northwell Hempstead NY USA. Institute of Behavioral Science Feinstein Institutes for Medical Research Northwell Health Manhasset NY USA. Department of Brain and Behavioral Sciences University of Pavia Pavia Italy. Centre for Neuropsychiatric Schizophrenia Research CNSR Mental Health Centre Glostrup Denmark. Department of Clinical Medicine University of Copenhagen Copenhagen Denmark. Department of Psychiatry and Psychotherapy Jena University Hospital Jena Germany. Department of Psychology & Neuroscience Temple University Philad

Individuals at clinical high risk for psychosis (CHR) have variable clinical outcomes and low conversion rates, limiting development of novel and personalized treatments. Moreover, given risks of antipsychotic drugs, safer effective medications for CHR individuals are needed. The Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ) program was launched to address this need. Based on past CHR and schizophrenia studies, AMP SCZ assessed electroencephalography (EEG)-based event-related potential (ERP), event-related oscillation (ERO), and resting EEG power spectral density (PSD) measures, including mismatch negativity (MMN), auditory and visual P300 to target (P3b) and novel (P3a) stimuli, 40-Hz auditory steady state response, and resting EEG PSD for traditional frequency bands (eyes open/closed). Here, in an interim analysis of AMP SCZ EEG measures, we assess test-retest reliability and stability over sessions (baseline, month-2 follow-up) in CHR (n = 654) and community control (CON; n = 87) participants. Reliability was calculated as Generalizability (G)-coefficients, and changes over session were assessed with paired t-tests. G-coefficients were generally good to excellent in both groups (CHR: mean = 0.72, range = 0.49-0.85; CON: mean = 0.71, range = 0.44-0.89). Measure magnitudes significantly (p < 0.001) decreased over session (MMN, auditory and visual target P3b, visual novel P3a, 40-Hz ASSR) and/or over runs within sessions (MMN, auditory/visual novel P3a and target P3b), consistent with habituation effects. Despite these small systematic habituation effects, test-retest reliabilities of the AMP SCZ EEG-based measures are sufficiently strong to support their use in CHR studies as potential predictors of clinical outcomes, markers of illness progression, and/or target engagement or secondary outcome measures in controlled clinical trials.

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Publisher Correction: Divergent SARS-CoV-2 variant emerges in white-tailed deer with deer-to-human transmission

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Nature microbiology 2023年第1期8卷 188页

作者： Bradley Pickering Oliver Lung Finlay Maguire Peter Kruczkiewicz Jonathon D Kotwa Tore Buchanan Marianne Gagnier Jennifer L Guthrie Claire M Jardine Alex Marchand-Austin Ariane Massé Heather McClinchey Kuganya Nirmalarajah Patryk Aftanas Juliette Blais-Savoie Hsien-Yao Chee Emily Chien Winfield Yim Andra Banete Bryan D Griffin Lily Yip Melissa Goolia Matthew Suderman Mathieu Pinette Greg Smith Daniel Sullivan Josip Rudar Oksana Vernygora Elizabeth Adey Michelle Nebroski Guillaume Goyette Andrés Finzi Geneviève Laroche Ardeshir Ariana Brett Vahkal Marceline Côté Allison J McGeer Larissa Nituch Samira Mubareka Jeff Bowman National Centre for Foreign Animal Disease Canadian Food Inspection Agency Winnipeg Manitoba Canada. bradley.pickering@canada.ca. Department of Veterinary Microbiology and Preventative Medicine College of Veterinary Medicine Iowa State University Ames IA USA. bradley.pickering@canada.ca. Department of Medical Microbiology and Infectious Diseases University of Manitoba Winnipeg Manitoba Canada. bradley.pickering@canada.ca. National Centre for Foreign Animal Disease Canadian Food Inspection Agency Winnipeg Manitoba Canada. Department of Biological Sciences University of Manitoba Winnipeg Manitoba Canada. Faculty of Computer Science Dalhousie University Halifax Nova Scotia Canada. Department of Community Health & Epidemiology Dalhousie University Halifax Nova Scotia Canada. Shared Hospital Laboratory Toronto Ontario Canada. Sunnybrook Research Institute Toronto Ontario Canada. Wildlife Research and Monitoring Section Ontario Ministry of Natural Resources and Forestry Peterborough Ontario Canada. Ministère des Forêts de la Faune et des Parcs Quebec City Quebec Canada. Public Health Ontario Toronto Ontario Canada. Department of Microbiology & Immunology Western University London Toronto Ontario Canada. Canadian Wildlife Health Cooperative Ontario-Nunavut Department of Pathobiology University of Guelph Guelph Ontario Canada. Public Health Health Protection and Surveillance Policy and Programs Branch Ontario Ministry of Health Toronto Ontario Canada. Centre de Recherche du CHUM Montréal Quebec Canada. Département de Microbiologie Infectiologie et Immunologie Université de Montréal Montréal Quebec Canada. Department of Biochemistry Microbiology and Immunology University of Ottawa Ottawa Ontario Canada. Ottawa Institute of Systems Biology University of Ottawa Ottawa Ontario Canada. Centre for Infection Immunity and Inflammation University of Ottawa Ottawa Ontario Canada. Sinai Health System Toronto Ontario Canada. Department of Laborat

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Analysis of more than 400,000 women provides case-control evidence for BRCA1 and BRCA2 variant classification

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Nature communications 2025年第1期16卷 4852页

作者： Maria Zanti Denise G O'Mahony Michael T Parsons Leila Dorling Joe Dennis Nicholas J Boddicker Wenan Chen Chunling Hu Marc Naven Kristia Yiangou Thomas U Ahearn Christine B Ambrosone Irene L Andrulis Antonis C Antoniou Paul L Auer Caroline Baynes Clara Bodelon Natalia V Bogdanova Stig E Bojesen Manjeet K Bolla Kristen D Brantley Nicola J Camp Archie Campbell Jose E Castelao Melissa H Cessna Jenny Chang-Claude Fei Chen Georgia Chenevix-Trench Don M Conroy Kamila Czene Arcangela De Nicolo Susan M Domchek Thilo Dörk Alison M Dunning A Heather Eliassen D Gareth Evans Peter A Fasching Jonine D Figueroa Henrik Flyger Manuela Gago-Dominguez Montserrat García-Closas Gord Glendon Anna González-Neira Felix Grassmann Andreas Hadjisavvas Christopher A Haiman Ute Hamann Steven N Hart Mikael B A Hartman Weang-Kee Ho James M Hodge Reiner Hoppe Sacha J Howell Anna Jakubowska Elza K Khusnutdinova Yon-Dschun Ko Peter Kraft Vessela N Kristensen James V Lacey Jingmei Li Geok Hoon Lim Sara Lindström Artitaya Lophatananon Craig Luccarini Arto Mannermaa Maria Elena Martinez Dimitrios Mavroudis Roger L Milne Kenneth Muir Katherine L Nathanson Rocio Nuñez-Torres Nadia Obi Janet E Olson Julie R Palmer Mihalis I Panayiotidis Alpa V Patel Paul D P Pharoah Eric C Polley Muhammad U Rashid Kathryn J Ruddy Emmanouil Saloustros Elinor J Sawyer Marjanka K Schmidt Melissa C Southey Veronique Kiak-Mien Tan Soo Hwang Teo Lauren R Teras Diana Torres Amy Trentham-Dietz Thérèse Truong Celine M Vachon Qin Wang Jeffrey N Weitzel Siddhartha Yadav Song Yao Gary R Zirpoli Melissa S Cline Peter Devilee Sean V Tavtigian David E Goldgar Fergus J Couch Douglas F Easton Amanda B Spurdle Kyriaki Michailidou Biostatistics Unit The Cyprus Institute of Neurology & Genetics Nicosia Cyprus. Department of Medical Genetics Oslo University Hospital Oslo Norway. Population Health Program QIMR Berghofer Medical Research Institute Brisbane Queensland Australia. Centre for Cancer Genetic Epidemiology Department of Public Health and Primary Care University of Cambridge Cambridge UK. Department of Quantitative Health Sciences Division of Computational Biology Mayo Clinic Rochester MN USA. Department of Laboratory Medicine and Pathology Mayo Clinic Rochester MN USA. Division of Cancer Epidemiology and Genetics National Cancer Institute National Institutes of Health Department of Health and Human Services Bethesda MD USA. Department of Cancer Prevention and Control Roswell Park Comprehensive Cancer Institute Buffalo NY USA. Fred A. Litwin Center for Cancer Genetics Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital Toronto Ontario Canada. Department of Molecular Genetics University of Toronto Toronto Ontario Canada. Division of Biostatistics Data Science Institute and Cancer Center Medical College of Wisconsin Milwaukee WI USA. Centre for Cancer Genetic Epidemiology Department of Oncology University of Cambridge Cambridge UK. Department of Population Science American Cancer Society Atlanta GA USA. Radiation Oncology Research Unit Hannover Medical School Hannover Germany. Copenhagen General Population Study Herlev and Gentofte Hospital Copenhagen University Hospital Herlev Denmark. Department of Clinical Biochemistry Herlev and Gentofte Hospital Copenhagen University Hospital Herlev Denmark. Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark. Department of Medical Oncology Dana-Farber Cancer Institute Boston MA USA. Department of Internal Medicine and Huntsman Cancer Institute University of Utah Salt Lake City UT USA. Centre for Genomic and Experimental Medicine Institute of Genetics & Cancer The University of Ed

Clinical genetic testing identifies variants causal for hereditary cancer, information that is used for risk assessment and clinical management. Unfortunately, some variants identified are of uncertain clinical significance (VUS), complicating patient management. Case-control data is one evidence type used to classify VUS. As an initiative of the Evidence-based Network for the Interpretation of Germline Mutant Alleles (ENIGMA) Analytical Working Group we analyze germline sequencing data of BRCA1 and BRCA2 from 96,691 female breast cancer cases and 302,116 controls from three studies: the BRIDGES study of the Breast Cancer Association Consortium, the Cancer Risk Estimates Related to Susceptibility consortium, and the UK Biobank. We observe 11,207 BRCA1 and BRCA2 variants, with 6909 being coding, covering 23.4% of BRCA1 and BRCA2 VUS in ClinVar and 19.2% of ClinVar curated (likely) benign or pathogenic variants. Case-control likelihood ratio (ccLR) evidence is highly consistent with ClinVar assertions for (likely) benign or pathogenic variants; exhibiting 99.1% sensitivity and 95.3% specificity for BRCA1 and 93.3% sensitivity and 86.6% specificity for BRCA2. This approach provides case-control evidence for 787 unclassified variants; these include 579 with strong or moderate benign evidence and 10 with strong pathogenic evidence for which ccLR evidence is sufficient to alter clinical classification.

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Author Correction: Towards symbiotic approaches between universities, sustainable development, and cities

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Scientific reports 2023年第1期13卷 552页

作者： Walter Leal Filho Liliana Caughman Maria Alzira Pimenta Dinis Fernanda Frankenberger Anabela Marisa Azul Amanda Lange Salvia Department of Natural Sciences Manchester Metropolitan University Chester Street Manchester M115GD UK. Research and Transfer Centre "Sustainable Development and Climate Change Management" Hamburg University of Applied Sciences Ulmenliet 20 21033 Hamburg Germany. Postdoctoral Research Scholar Earth Systems Science for the Anthropocene Arizona State University Tempe USA. UFP Energy Environment and Health Research Unit (FP-ENAS) University Fernando Pessoa (UFP) Praça 9 de Abril 349 4249-004 Porto Portugal. Business School PUCPR Pontifical Catholic University of Paraná Rua Imaculada Conceição Curitiba 1155 Brazil. Brazil Business School Universidade Positivo Rua Pedro Viriato Parigot de Souza Curitiba 5300 Brazil. CNC-Center for Neuroscience and Cell Biology University of Coimbra 3004-504 Coimbra Portugal. CIBB-Center for Innovative Biomedicine and Biotechnology University of Coimbra Coimbra Portugal. IIIUC-Institute for Interdisciplinary Research University of Coimbra 3030-789 Coimbra Portugal. Graduate Program in Civil and Environmental Engineering University of Passo Fundo Campus I - BR285 São José Passo Fundo RS 99052-900 Brazil. amandasalvia@***. European School of Sustainability Science and Research Hamburg University of Applied Sciences Ulmenliet 20 21033 Hamburg Germany. amandasalvia@***.

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Author Correction: BigNeuron: a resource to benchmark and predict performance of algorithms for automated tracing of neurons in light microscopy datasets

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Nature methods 2024年第10期21卷 1959页

作者： Linus Manubens-Gil Zhi Zhou Hanbo Chen Arvind Ramanathan Xiaoxiao Liu Yufeng Liu Alessandro Bria Todd Gillette Zongcai Ruan Jian Yang Miroslav Radojević Ting Zhao Li Cheng Lei Qu Siqi Liu Kristofer E Bouchard Lin Gu Weidong Cai Shuiwang Ji Badrinath Roysam Ching-Wei Wang Hongchuan Yu Amos Sironi Daniel Maxim Iascone Jie Zhou Erhan Bas Eduardo Conde-Sousa Paulo Aguiar Xiang Li Yujie Li Sumit Nanda Yuan Wang Leila Muresan Pascal Fua Bing Ye Hai-Yan He Jochen F Staiger Manuel Peter Daniel N Cox Michel Simonneau Marcel Oberlaender Gregory Jefferis Kei Ito Paloma Gonzalez-Bellido Jinhyun Kim Edwin Rubel Hollis T Cline Hongkui Zeng Aljoscha Nern Ann-Shyn Chiang Jianhua Yao Jane Roskams Rick Livesey Janine Stevens Tianming Liu Chinh Dang Yike Guo Ning Zhong Georgia Tourassi Sean Hill Michael Hawrylycz Christof Koch Erik Meijering Giorgio A Ascoli Hanchuan Peng Institute for Brain and Intelligence Southeast University Nanjing China. Microsoft Corporation Redmond WA USA. Tencent AI Lab Bellevue WA USA. Computing Environment and Life Sciences Directorate Argonne National Laboratory Lemont IL USA. Kaya Medical Seattle WA USA. University of Cassino and Southern Lazio Cassino Italy. Center for Neural Informatics Structures and Plasticity Krasnow Institute for Advanced Study George Mason University Fairfax VA USA. Faculty of Information Technology Beijing University of Technology Beijing China. Beijing International Collaboration Base on Brain Informatics and Wisdom Services Beijing China. Nuctech Netherlands Rotterdam the Netherlands. Janelia Research Campus Howard Hughes Medical Institute Ashburn VA USA. Department of Electrical and Computer Engineering University of Alberta Edmonton Alberta Canada. Ministry of Education Key Laboratory of Intelligent Computation and Signal Processing Anhui University Hefei China. Paige AI New York NY USA. Scientific Data Division and Biological Systems and Engineering Division Lawrence Berkeley National Lab Berkeley CA USA. Helen Wills Neuroscience Institute and Redwood Center for Theoretical Neuroscience UC Berkeley Berkeley CA USA. RIKEN AIP Tokyo Japan. Research Center for Advanced Science and Technology (RCAST) The University of Tokyo Tokyo Japan. School of Computer Science University of Sydney Sydney New South Wales Australia. Texas A&M University College Station TX USA. Cullen College of Engineering University of Houston Houston TX USA. Graduate Institute of Biomedical Engineering National Taiwan University of Science and Technology Taipei Taiwan. National Centre for Computer Animation Bournemouth University Poole UK. PROPHESEE Paris France. Department of Neuroscience Columbia University New York NY USA. Mortimer B. Zuckerman Mind Brain Behavior Institute Columbia University New York NY USA. Department of Computer Science Northern Illinois Universit

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Erratum to 'Relation Between Mitral Valve Prolapse and Erectile Dysfunction (from a Nationwide Case-Control Study)': The American Journal of Cardiology 2019 Nov 15;124(10):1590-1593./ doi: 10.1016/***.2019.08.010

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The American journal of cardiology 2021年 142卷 161页

作者： Shiu-Dong Chung Ju-Chi Liu Tsai-Ning Lou Ben-Chang Shia Herng-Ching Lin Li-Ting Kao Division of Urology Department of Surgery Far Eastern Memorial Hospital Taipei Taiwan Department of Computer Science and Engineering and Graduate Program in Biomedical Informatics College of Informatics Yuan-Ze University Chung-Li Taiwan Sleep Research Center Taipei Medical University Hospital Taipei Taiwan. Department of Internal Medicine School of Medicine College of Medicine Taipei Medical University Taipei Taiwan Division of Cardiovascular Medicine Department of Medicine Medical University Hospital-Shuang Ho Hospital TaipeiTaiwan. School of Health Care Administration Taipei Medical University Taipei Taiwan. Big Data Research Center Taipei Medical University Taipei Taiwan. Sleep Research Center Taipei Medical University Hospital Taipei Taiwan School of Health Care Administration Taipei Medical University Taipei Taiwan Graduate Institute of Life Sciences National Defense Medical Center Taipei Taiwan Department of Pharmacy Practice Tri-Service General Hospital Taipei Taiwan School of Pharmacy National Defense Medical Center Taipei Taiwan.. Electronic address: kaoliting@***.

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Correction to: Authors’ Reply to Letter to the Editor: Continued improvement to genetic diversity indicator for CBD

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Conservation Genetics 2021年第4期22卷 537-539页

作者： Laikre, Linda Hohenlohe, Paul A. Allendorf, Fred W. Bertola, Laura D. Breed, Martin F. Bruford, Michael W. Funk, W. Chris Gajardo, Gonzalo González-Rodríguez, Antonio Grueber, Catherine E. Hedrick, Philip W. Heuertz, Myriam Hunter, Margaret E. Johannesson, Kerstin Liggins, Libby MacDonald, Anna J. Mergeay, Joachim Moharrek, Farideh O’Brien, David Ogden, Rob Orozco-terWengel, Pablo Palma-Silva, Clarisse Pierson, Jennifer Paz-Vinas, Ivan Russo, Isa-Rita M. Ryman, Nils Segelbacher, Gernot Sjögren-Gulve, Per Waits, Lisette P. Vernesi, Cristiano Hoban, Sean Division of Population Genetics Department of Zoology Stockholm University Stockholm Sweden Institute for Bioinformatics and Evolutionary Studies Department of Biological Sciences University of Idaho Moscow USA Division of Biological Sciences University of Montana Missoula USA City College of New York New York USA College of Science and Engineering Flinders University Bedford Park Australia School of Biosciences Cardiff University Cardiff Wales UK Graduate Degree Program in Ecology Department of Biology Colorado State University Fort Collins USA Universidad de Los Lagos Lab Genetics Aquaculture & Biodiversity Osorno Chile Instituto de Investigaciones en Ecosistemas y Sustentabilidad Universidad Nacional Autónoma de México Morelia Mexico School of Life and Environmental Sciences Faculty of Science The University of Sydney Sydney Australia School of Life Sciences Arizona State University Tempe USA INRAE Univ. Bordeaux Biogeco Cestas France U.S. Geological Survey Wetland and Aquatic Research Center Gainesville USA Department of Marine Sciences University of Gothenburg Tjärnö Strömstad Sweden School of Natural and Computational Sciences Massey University Auckland New Zealand The John Curtin School of Medical Research/Research School of Biology The Australian National University Acton Australia Research Institute for Nature and Forest Geraardsbergen Belgium Aquatic Ecology Evolution and Conservation KULeuven Leuven Belgium Novo Nordisk Foundation Center for Basic Metabolic Research Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark Faculty of Biological Sciences Tarbiat Modares University Tehran Iran Scottish Natural Heritage Inverness UK Royal (Dick) School of Veterinary Studies and the Roslin Institute University of Edinburgh Midlothian UK Department of Plant Science Institute of Biology University of Campinas Campinas Brazil Australian Wildlife Conservancy Subiaco East Australia Laboratoire Evolution & Div

A correction to this paper has been published: https://***/10.1007/s10592-021-01376-9

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