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Anti-malaria drug artesunate protects bronchial epithelium from DNA damage induced by asthma

中国药理学与毒理学杂志 2015年第S1期29卷 25-26页

作者： TzeKheeCHAN WNFeliciaTAN BevinPENGELWARD WSFredWONG Department of Pharmacology Yong Loo Lin School of Medicine National University Health System Singapore Immunology Program Life Science Institute National University of Singapore Interdisciplinary Research Group in Infectious Diseases Singapore-MIT Alliance for Research and Technology Singapore Department of Biological Engineering Massachusetts Institute of Technology Cambridge MA 02139 USA

OBJECTIVE To investigate the genome protective effects of anti-malaria drug,artesunate in an experimental allergic asthma *** Mice were sensitized on day 0 and 7 and challenged on day 14 with 100μg house dust mite(HDM)via intratracheal ***(30mg·kg-1)was administered intra-peritoneally on day 6,7,8,13,14 and *** were collected on day 1,3 and 5 post last HDM-challenge for analysis of air way inflammation and DNA *** sections were immunofluorescence(IF)-stained for DNA double strand breaks(DSBs)markers,γH2AX and *** of DNA repair proteins Ku70 and Rad51,which are involved in non-homologous end joining(NHEJ)and homologous recombination(HR)DNA DSB repair pathways respectively,were *** quantify cell death in asthmatic lung,TUNEL staining was *** assay,a single cell gel electrophoresis was employed to detect DNA damage induced by HDM in BEAS-2Bhuman bronchial epithelial cell line,in *** Artesunate treatment significantly reduces immune cells infiltration in BAL fluid of asthmatic mice,collected on day 3 and 5 ***,artesuante is able to protect bronchial epithelium from DNA DSBs induced by asthma,as detected by the reduced level of γH2AX and 53BP1 foci formation in the *** genome protective effect is evident even on day 1 post-challenge,when immune cells infiltration remained *** indicates that artesunate confers protection on bronchial epithelium in the presence of ***,artesunate is also able to reduce cell death in asthmatic lung revealed by TUNEL assay and cleaved caspase 3 ***,the levels of DNA repair proteins in artesuante-treated asthmatic mice are unchanged as compared to HDM-only mice,suggesting that artesunate treatment does not augment the level of DNA repair *** human bronchial epithelial BEAS-2 Bcells were exposed to HDMin vitro,we observed an increase in the levels of DNA ***(60μ

关键词： artesunate HDM asthma DNA damage cell death comet

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Getting Undergraduates Ready for China’s Belt and Road Initiative (BRI) Through an Overseas Experiential Learning Project

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China and the World 2021年第3期4卷

作者： Andrew Min Han Chin Thomas Menkhoff Hans-Dieter Evers Hoong Hui Daniel Gn Kevin Koh Chester Wey Lee Patrick H. M. Loh Linda Low Sebastian Tan Teng Seng Teo Natalie Yap Lee Kong Chian School of Business Singapore Management University (SMU) 81 Victoria Street Singapore 188065 Singapore Andrew Chin Min Han graduated from Tsinghua University in Beijing China with a Tsinghua–MIT Sloan International Master of Business Administration degree under the Singapore Government’s Asian Business Fellowship (ABF) scholarship program. He is the Program Director of Singapore Management University (SMU) Executive Certificate in China Business and of the SMU Internationalisation Series. He teaches as an Adjunct Faculty of Strategy and Organisation at the SMU Lee Kong Chian School of Business since January 2017. He teaches effectively in English and Chinese. With over 23 years of experience in education and publishing industry in Asia Andrew Chin’s multi-sector career has enabled him to experience the full spectrum of the education industry in his roles as the Singapore EDB Officer handling the World-Class University portfolio and the Specialist Information and Publishing Industry portfolio Chief Representative and Country Manager (China) at Thomson Learning (Fortune 500 company) and Co-founder and CEO for an early childhood education business. Andrew was a Business Development Director (Universities) at Sodexo Group (Fortune 500 company) for the Asia-Pacific region. After working 10 years in Beijing China Andrew returned to Singapore in 2012 to work closely with the top leadership at Singapore Management University on the SMU China & East Asia Initiatives. Thomas Menkhoff is the Professor of Organisational Behaviour & Human Resources (Education) at the Lee Kong Chian School of Business Singapore Management University (SMU). Two of his recent publications include: (i) Menkhoff Thomas Ning Kan Siew Evers Hans-Dieter and Chay Yue Wah eds. Living in Smart Cities: Innovation and Sustainability (New Jersey: World Scientific Publishing 2018) and (ii) Chay Yue Wah Menkhoff Thomas and Low Linda eds. China’s Belt and Road Initiative — Understanding the Dynamics of a Global Transfor

In this paper, we explain how an experiential learning course and study tour to Gansu Province (People’s Republic of China) enabled undergraduates at the Singapore Management University (SMU) to acquire 21st-century competencies and higher-order thinking skills by analyzing and evaluating specific aspects of China’s Belt and Road Initiative (BRI) and China–Singapore (Chongqing) Connectivity Initiative — New International Land–Sea Trade Corridor (CCI-ILSTC) with emphasis on developing viable Go-To-Market (GTM) strategies aimed at selling Gansu produce in four Southeast Asian markets. We share how the course was designed to support the attainment of key learning goals and discuss how we turned pedagogical aspirations into concrete learning outcomes. We introduce key aspects of the so-called “SMU-XO” project that the students conducted in partnership with an industry partner, Pacific International Lines (PIL), and discuss how the project work helped learners to gain global competency by (i) examining critical issues related to BRI such as multi-modal infrastructure connectivity, (ii) appreciating the local perspectives of project stakeholders in Lanzhou and Shanghai and (iii) successfully interacting with people from different cultures, namely China, Indonesia, Vietnam, Malaysia and Thailand.

关键词： Experiential learning Singapore China Belt and Road Initiative (BRI)

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Dysregulated mechanisms underlying Duchenne muscular dystrophy from co-expression network preservation analysis

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BMC Research Notes 2015年第1期8卷 1-10页

作者： Mukund, Kavitha Subramaniam, Shankar Bioinformatics and System Biology Graduate Program University of California San Diego MC0412 9500 Gilman Drive San Diego 92093 CA United States Departments of Bioengineering Computer Science and Engineering Cellular and Molecular Medicine Chemistry and Biochemistry University of California San Diego 9500 Gilman Drive San Diego 92093 CA United States

Background: Duchenne Muscular Dystrophy (DMD) is an X-linked recessive disorder with its primary insult on the skeletal muscle. Severe muscle wasting, chronic inflammation and fibrosis characterize dystrophic muscle. Here we identify dysregulated pathways in DMD utilizing a co-expression network approach as described in Weighted Gene Co-expression Network Analysis (WGCNA). Specifically, we utilize WGCNA's "preservation" statistics to identify gene modules that exhibit a weak conservation of network topology within healthy and dystrophic networks. Preservation statistics rank modules based on their topological metrics such as node density, connectivity and separability between networks. Methods: Raw data for DMD was downloaded from Gene Expression Omnibus (GSE6011) and suitably preprocessed. Co-expression networks for each condition (healthy and dystrophic) were generated using the WGCNA library in R. Preservation of healthy network edges was evaluated with respect to dystrophic muscle and vice versa using WGCNA. Highly exclusive gene pairs for each of the low preserved modules within both networks were also determined using a specificity measure. Results: A total of 11 and 10 co-expressed modules were identified in the networks generated from 13 healthy and 23 dystrophic samples respectively. 5 out of the 11, and 4 out of the 10 modules were identified as exhibiting none-to-weak preservation. Functional enrichment analysis identified that these weakly preserved modules were highly relevant to the condition under study. For instance, weakly preserved dystrophic module D2 exhibited the highest fraction of genes exclusive to DMD. The highly specific gene pairs identified within these modules were enriched for genes activated in response to wounding and affect the extracellular matrix including several markers such as SPP1, MMP9 and ITGB2. Conclusion: The proposed approach allowed us to identify clusters of genes that are non-randomly associated with the disease. Furthe

关键词： Co-expression network Differential network analysis Duchenne muscular dystrophy Preservation statistics Skeletal muscle

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Abstracts from the 20th International Symposium on Signal Transduction at the Blood-Brain Barriers Abstracts

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FLUIDS AND BARRIERS OF THE CNS 2017年第SUPPL 2期14卷 27-27页

作者： [Anonymous] The Jerzy Kukuczka Academy of Physical Education Katowice Poland The Institute of Animal Physiology and Food Research Polish Academy of Sciences Olsztyn Poland University of Miami Miami FL USA Institute of Pharmaceutical Science King’s College London London United Kingdom Department of Ophthalmology and Molecular and Integrative Physiology The University of Michigan Ann Arbor MI USA Department of Internal Medicine and Cardiology The University of Michigan Ann Arbor MI USA School of Medicine Department of Cellular and Molecular Medicine Koc University Istanbul Turkey Department of Cellular and Molecular Medicine Medical Faculty Koc University Istanbul Turkey Department of Neuroscience School of Medicine Koc University Istanbul Turkey Department of Neuroscience Medical Faculty Koc University Istanbul Turkey Department of Laboratory Animals Science Aziz Sancar Experimental Medicine Research Institute Istanbul University Istanbul Turkey Department of Neuroscience Aziz Sancar Experimental Medicine Research Institute Istanbul University Istanbul Turkey School of Medicine Koc University Istanbul Turkey Department of Forensic Science Istanbul Faculty of Medicine Istanbul University Istanbul Turkey Department of Histology and Embryology School of Medicine Koc University Istanbul Turkey Department of Histology and Embryology Istanbul Faculty of Medicine Istanbul University Istanbul Turkey Department of Physiology School of Medicine Koc University Istanbul Turkey Theodor Kocher Institute University of Bern Bern Switzerland Institute of Veterinary Physiology Vetsuisse Faculty University of Zurich Zurich Switzerland Zurich Center for Integrative Human Physiology University of Zurich Zurich Switzerland Zurich Center of Integrative Human Physiology University of Zurich Zurich Switzerland Institute for Veterinary Physiology and Zurich Center for Integrative Human Physiology University of Zurich Zurich Switzerland Institute of Veterinary Physiology Univer

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"what We Breathe Impacts Our health: Improving Understanding of the Link between Air Pollution and health"

"what We Breathe Impacts Our Health: Improving Understanding...

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作者： West, J. Jason Cohen, Aaron Dentener, Frank Brunekreef, Bert Zhu, Tong Armstrong, Ben Bell, Michelle L. Brauer, Michael Carmichael, Gregory Costa, Dan L. Dockery, Douglas W. Kleeman, Michael Krzyzanowski, Michal Künzli, Nino Liousse, Catherine Lung, Shih-Chun Candice Martin, Randall V. Pöschl, Ulrich Pope, C. Arden Roberts, James M. Russell, Armistead G. Wiedinmyer, Christine Environmental Sciences and Engineering University of North Carolina at Chapel Hill Chapel HillNC27599 United States Health Effects Institute BostonMA02110 United States European Commission Joint Research Centre Institute for Environment and Sustainability IspraI. 21027 Italy Institute for Risk Assessment Sciences Universiteit Utrecht Julius Center for Health Sciences and Primary Care University Medical Center Utrecht Utrecht3584 CJ Netherlands State Key Lab for Environmental Simulation and Pollution Control College of Environmental Science and Engineering Peking University Beijing100871 China Social and Environmental Health Research London School of Hygiene and Tropical Medicine LondonWC1E 7HT United Kingdom School of Forestry and Environmental Studies Yale University New HavenCT06511 United States School of Population and Public Health University of British Columbia VancouverBCV6T 1Z3 Canada Chemical and Biochemical Engineering University of Iowa Iowa CityIA52242 United States Air Climate and Energy Research Program Office of Research and Development Environmental Protection Agency DurhamNC27705 United States Harvard T. H. Chan School of Public Health BostonMA02115 United States Civil and Environmental Engineering University of California at Davis DavisCA95616 United States Environmental Research Group King's College London LondonSE1 9NH United Kingdom Epidemiology and Public Health Swiss Tropical and Public Health Institute Basel Switzerland University of Basel Basel Switzerland Laboratoire d' Aérologie CNRS-Université de Toulouse Toulouse31400 France Research Center for Environmental Changes Academia Sinica Taipei Taiwan Physics and Atmospheric Science Dalhousie University HalifaxNSB3H 4R2 Canada Harvard-Smithsonian Center for Astrophysics CambridgeMA02138 United States Multiphase Chemistry Department Max Planck Institute for Chemistry Mainz55128 Germany Economics Brigham Young University ProvoUT84602 United States Ea

Air pollution contributes to the premature deaths of millions of people each year around the world, and air quality problems are growing in many developing nations. While past policy efforts have succeeded in reducing particulate matter and trace gases in North America and Europe, adverse health effects are found at even these lower levels of air pollution. Future policy actions will benefit from improved understanding of the interactions and health effects of different chemical species and source categories. Achieving this new understanding requires air pollution scientists and engineers to work increasingly closely with health scientists. In particular, research is needed to better understand the chemical and physical properties of complex air pollutant mixtures, and to use new observations provided by satellites, advanced in situ measurement techniques, and distributed micro monitoring networks, coupled with models, to better characterize air pollution exposure for epidemiological and toxicological research, and to better quantify the effects of specific source sectors and mitigation strategies. © 2016 American Chemical Society.

关键词： health

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26th Annual Computational Neuroscience Meeting (CNS*2017): Part 3 Antwerp, Belgium. 15-20 July 2017 Abstracts

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BMC NEUROscience 2017年第SUPPL 1期18卷 95-176页

作者： [Anonymous] Department of Neuroscience Yale University New Haven CT 06520 USA Department Physiology & Pharmacology SUNY Downstate Brooklyn NY 11203 USA NYU School of Engineering 6 MetroTech Center Brooklyn NY 11201 USA Departament de Matemàtica Aplicada Universitat Politècnica de Catalunya Barcelona 08028 Spain Institut de Neurobiologie de la Méditerrannée (INMED) INSERM UMR901 Aix-Marseille Univ Marseille France Center of Neural Science New York University New York NY USA Aix-Marseille Univ INSERM INS Inst Neurosci Syst Marseille France Laboratoire de Physique Théorique et Modélisation CNRS UMR 8089 Université de Cergy-Pontoise 95300 Cergy-Pontoise Cedex France Department of Mathematics and Computer Science ENSAT Abdelmalek Essaadi’s University Tangier Morocco Laboratory of Natural Computation Department of Information and Electrical Engineering and Applied Mathematics University of Salerno 84084 Fisciano SA Italy Department of Medicine University of Salerno 84083 Lancusi SA Italy Dipartimento di Fisica Università degli Studi Aldo Moro Bari and INFN Sezione Di Bari Italy Data Analysis Department Ghent University Ghent Belgium Coma Science Group University of Liège Liège Belgium Cruces Hospital and Ikerbasque Research Center Bilbao Spain BIOtech Department of Industrial Engineering University of Trento and IRCS-PAT FBK 38010 Trento Italy Department of Data Analysis Ghent University Ghent 9000 Belgium The Wellcome Trust Centre for Neuroimaging University College London London WC1N 3BG UK Department of Electronic Engineering NED University of Engineering and Technology Karachi Pakistan Blue Brain Project École Polytechnique Fédérale de Lausanne Lausanne Switzerland Departement of Mathematics Swansea University Swansea Wales UK Laboratory for Topology and Neuroscience at the Brain Mind Institute École polytechnique fédérale de Lausanne Lausanne Switzerland Institute of Mathematics University of Aberdeen Aberdeen Scotland UK Department of Integrativ

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Metadata Correction: Importance-Performance Analysis of Personal health Records in Taiwan: A Web-Based Survey

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Journal of medical Internet research 2017年第6期19卷 e209页

作者： Hsiao-Hsien Rau Yi-Syuan Wu Chi-Ming Chu Fu-Chung Wang Min-Huei Hsu Chi-Wen Chang Kang-Hua Chen Yen-Liang Lee Senyeong Kao Yu-Lung Chiu Hsyien-Chia Wen Anis Fuad Chien-Yeh Hsu Hung-Wen Chiu Graduate Institute of Biomedical Informatics Taipei Medical University Taipei Taiwan. Administration Department Healthconn Corp Taipei Taiwan. Institute of Medical Informatics Department of Computer Science of Information Engineering National Cheng Kung University Tainan Taiwan. School Of Public Health National Defense Medical Center Taiepi Taiwan. National Health Insurance Administration Ministry of Health and Welfare Taiepi Taiwan. School of Nursing College of Medicine Chang Gung University Linkou Taiwan. Division of Endocrinology Department of Pediatrics Linkou Chang Gung Memorial Hospital Linkou Taiwan. Internet of Things Laboratory Chunghwa Telecom Laboratories TaoYuen Taiwan. School of Health Care Administration Taipei Medical University Taipei Taiwan. Department of Biostatistics Epidemiology and Population Health Faculty of Medicine Universitas Gadjah Mada Yogyakarta Indonesia. Department of Information Management National Taipei University of Nursing and Health Sciences Taipei Taiwan. Master Program in Global Health and Development Taipei Medical University Taipei Taiwan.

[This corrects the article DOI: .].

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26th Annual Computational Neuroscience Meeting (CNS*2017) of the Organization for Computational Neuroscience Antwerp, Belgium, July 15-20, 2017

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BMC NEUROscience 2017年第SUPPL 1期18卷 59-59页

作者： [Anonymous] Indiana University Purdue University Indianapolis Indianapolis IN 46032 USA Stark Neurosciences Research Institute Indiana University School of Medicine Indianapolis IN 46032 USA Department of Mathematics East Carolina University Greenville NC 27858 USA Jülich Supercomputing Centre Forschungszentrum Jülich 52425 Jülich Germany Future Systems Swiss National Supercomputing Centre 8092 Zurich Switzerland User Engagement and Support Swiss National Supercomputing Centre 6900 Lugano Switzerland Institut de Neurosciences des Systèmes Aix Marseille Univ 13005 Marseille France Simulation Lab Neuroscience Forschungszentrum Jülich Jülich Germany Department of Experimental Psychology Ghent University 9000 Ghent Belgium Donders Center for Cognitive Neuroimaging Radboud University 6525HR Nijmegen The Netherlands Department of Electrical Computer and Energy Engineering University of Colorado Boulder CO 80309 USA Department of Neurosurgery Johns Hopkins School of Medicine Baltimore MD 21287 USA Department of Neurology Johns Hopkins School of Medicine Baltimore MD 21287 USA Department of Otolaryngology Johns Hopkins School of Medicine Baltimore MD 21287 USA INSERM U968 Paris France Sorbonne Universités UPMC University Paris 06 UMR_S 968 Institut de la Vision Paris France CNRS UMR_7210 Paris France Department of Computer Architecture and Technology University of Granada (CITIC) Granada Spain Sorbonne Universités UPMC Univ Paris 06 INSERM CNRS Institut de la Vision Paris France Department of Adaptive Machine Systems Osaka University Osaka Japan Department of Computer Science University of Cergy-Pontoise Cergy-Pontoise France Department of Physics and Astronomy College of Charleston Charleston SC 29424 USA School of Physics Faculty of Science University of Sydney Sydney NSW 2006 Australia Center of Excellence for Integrative Brain Function Australian Research Council Sydney Australia Max Planck Institute for Human Cognitive and Brain Sciences Saxony Lei

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Optimizing the conditions for carbon nanotube growth on silicon wafers coated with nickel thin films

Optimizing the conditions for carbon nanotube growth on sili...

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International Microsystems, Packaging, Assembly and Circuits Technology (IMPACT)

作者： Jhih-Syuan Teng Wei-Jie Chen Chuen-Horng Tsai Yao-Jane Hsu Pen-Cheng Wang Graduate Program for Science and Technology of Synchrotron Light Source National Tsing Hua University Hsinchu Taiwan National Synchrotron Radiation Research Center Hsinchu Taiwan Department of Engineering and System Science National Tsing Hua University Hsinchu Taiwan

In this work, the preparative conditions for optimizing growing carbon nanotube thin films on silicon wafers using an in-house chemical vapor deposition system was evaluated. We found that, when acetylene was used as the carbon source and nickel as the catalyst, the amount of carbon nanotubes grown on the silicon wafers was increased when the growth temperature was decreased from 800°C to 600°C. The carbon nanotubes were then characterized by Raman spectroscopy, X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM) and tunneling electron microscopy (TEM). The results show the obtained carbon nanotube thin films were mainly composed of multi-walled carbon nanotubes.

关键词： Carbon nanotubes Substrates Silicon Carbon Nickel Films

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The 5th International Conference on Biomedical engineering and Biotechnology (ICBEB 2016) Abstracts

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BMC MEDICAL IMAGING 2016年第SUPPL 1期16卷 65-65页

作者： [Anonymous] Department of MRI Shandong Medical Imaging Research Institute Affiliated to Shandong University Jinan Shandong 250021 People’s Republic of China Department of Interventional Radiology Shandong Provincial Hospital Affiliated to Shandong University Jinan Shandong 250021 People’s Republic of China College of Information Science and Technology Engr. Research Center of Digitized Textile & Fashion Tech. for Ministry of Education Donghua University Shanghai 201620 China Intelligent multimedia information processing Lab College of Software Northeastern University Shenyang Liaoning Province 110004 China Institute of Biomedical and Health Engineering Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Shenzhen 518055 China School of Computer Science and Technology Nanjing Normal University Nanjing China Department of Electrical Engineering The City College of New York CUNY New York USA Jiangsu Key Laboratory of 3D Printing Equipment and Manufacturing Nanjing China School of Electronic Science and Engineering Nanjing University Nanjing Jiangsu 210046 China College of Engineering Nanyang Technological University Singapore 639798 Singapore School of Electronic Information Shanghai Dianji University Shanghai China School of Natural Sciences and Mathematics Shepherd University Shepherdstown WV 25443 USA Davis College of Agriculture Natural Resources and Design West Virginia University Morgantown WV 26505 USA State Key Laboratory of Millimeter Waves Southeast University Nanjing 210096 China Center of Medical Physics and Technology Hefei Institutes of Physical Science Chinese Academy of Sciences Hefei China College of Agricultural and Life Sciences University of Florida Gainesville FL 32611 USA Courant Institute of Mathematical Sciences New York University New York NY 10012 USA Translational Imaging Division & MRI Unit Columbia University and New York State Psychiatric Institute New York NY 10032 USA Guangxi Key Laboratory of Manufacturing System & Adv

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