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Fungal diversity notes 253-366:taxonomic and phylogenetic contributions to fungal taxa

Fungal Diversity 2016年第3期78卷 1-237页

作者： Guo Jie Li Kevin D.Hyde Rui Lin Zhao Sinang Hongsanan Faten Awad Abdel-Aziz Mohamed A.Abdel-Wahab Pablo Alvarado Genivaldo Alves-Silva Joseph F.Ammirati Hiran A.Ariyawansa Abhishek Baghela Ali Hassan Bahkali Michael Beug D.Jayarama Bhat Dimitar Bojantchev Thitiya Boonpratuang Timur S.Bulgakov Erio Camporesi Marcela CBoro Oldriska Ceska Dyutiparna Chakraborty Jia Jia Chen K.W.Thilini Chethana Putarak Chomnunti Giovanni Consiglio Bao Kai Cui Dong Qin Dai Yu Cheng Dai Dinushani A.Daranagama Kanad Das Monika C.Dayarathne Eske De Crop Rafael J.V.De Oliveira Carlos Alberto Fragoso de Souza JoséIde Souza Bryn T.M.Dentinger Asha J.Dissanayake Mingkwan Doilom E.Ricardo Drechsler-Santos Masoomeh Ghobad-Nejhad Sean P.Gilmore Aristóteles Góes-Neto MichałGorczak Charles H.Haitjema Kalani Kanchana Hapuarachchi Akira Hashimoto Mao Qiang He John K.Henske Kazuyuki Hirayama Maria J.Iribarren Subashini C.Jayasiri Ruvishika S.Jayawardena Sun Jeong Jeon Gustavo H.Jerônimo Ana L.Jesus E.B.Gareth Jones Ji Chuan Kang Samantha C.Karunarathna Paul M.Kirk Sirinapa Konta Eric Kuhnert Ewald Langer Haeng Sub Lee Hyang Burm Lee Wen Jing Li Xing Hong Li Kare Liimatainen Diogo Xavier Lima Chuan Gen Lin Jian Kui Liu Xings Zhong Liu Zuo Yi Liu J.Jennifer Luangsa-ard Robert Lücking H.Thorsten Lumbsch Saisamorn Lumyong Eduardo M.Leaño Agostina V.Marano Misato Matsumura Eric H.C.McKenzie Suchada Mongkolsamrit Peter E.Mortimer Thi Thuong Thuong Nguyen Tuula Niskanen Chada Norphanphoun Michelle A.O’Malley Sittiporn Parnmen Julia Pawłowska Rekhani H.Perera Rungtiwa Phookamsak Chayanard Phukhamsakda Carmen L.A.Pires-Zottarelli Olivier Raspé Mateus A.Reck Sarah C.O.Rocha AndréL.C.M.Ade Santiago Indunil C.Senanayake Ledo Setti Qiu Ju Shang Sanjay K.Singh Esteban B.Sir Kevin V.Solomon Jie Song Prasert Srikitikulchai Marc Stadler Satinee Suetrong Hayato Takahashi Takumasa Takahashi Kazuaki Tanaka Li Ping Tang Kasun M.Thambugala Donnaya Thanakitpipattana Michael K.Theodorou Benjarong Thongbai Tuksaporn Thummarukcharoen Qing Tian Saowaluck Tibpromma Annemieke State Key Laboratory of Mycology Institute of MicrobiologyChinese Academy of SciencesNo 31st West Beichen RoadChaoyang DistrictBeijing 100101People’s Republic of China Centre of Excellence in Fungal Research and School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanPeople’s Republic of China Department of Botany and Microbiology College of ScienceKing Saud UniversityP.O.Box:2455Riyadh 1145Saudi Arabia Department of Botany and Microbiology Faculty of ScienceSohag UniversitySohag 82524Egypt ALVALAB C/La Rochela nº47E-39012 SantanderSpain Micolab Programa de Pós-Graduação em Biologia de FungosAlgas e PlantasDepartamento de BotânicaUniversidade Federal de Santa CatarinaCampus Universitário TrindadeCEP:88040-900 FlorianópolisSanta CatarinaBrazil Department of Biology University of WashingtonBox 351800SeattleWA 98195-1800USA Guizhou Key Laboratory of Agricultural Biotechnology Guizhou Academy of Agricultural SciencesGuiyang 550006GuizhouPeople’s Republic of China National Fungal Culture Collection of India(NFCCI) Biodiversity and Palaeobiology GroupMACS’Agharkar Research InstituteG.G.Agarkar RoadPune 411004India PO Box 116 HusumWA 98623-0116USA Formerly Department of BotanyGoa UniversityGoaIndia No.128/1-J Azad Housing SocietyCurcaP.O.Goa Velha 403108India *** 345 Shipwatch LaneHerculesCA 94547USA Microbe Interaction Laboratory(BMIT) BIOTECNational Science and Technology Development Agency(NSTDA)113 Thailand Science ParkThanon PhahonyothinTombon Khlong NuengAmphoeKhlong LuangPathum Thani 12120Thailand Academy of Biology and Biotechnology Southern Federal UniversityRostov-on-Don 344090Rostov regionRussia A.M.B.Gruppo Micologico Forlivese BAntonio“Cicognani” Via Roma Forlì Italy 18 A.M.B.Circolo Micologico“Giovanni Carini”C.P.314BresciaItaly Societàper gli Studi Naturalistici della Romagna C.P.144Bagnacavallo

Notes on 113 fungal taxa are compiled in this paper,including 11 new genera,89 new species,one new subspecies,three new combinations and seven reference *** geographic and taxonomic range of fungal taxa are *** the Ascomycota the new genera Angustospora(Testudinaceae),Camporesia(Xylariaceae),Clematidis,Crassiparies(Pleosporales genera incertae sedis),Farasanispora,Longiostiolum(Pleosporales genera incertae sedis),Multilocularia(Parabambusicolaceae),Neophaeocryptopus(Dothideaceae),Parameliola(Pleosporales genera incertae sedis),and Towyspora(Lentitheciaceae)are *** introduced species are Angustospora nilensis,Aniptodera aquibella,Annulohypoxylon albidiscum,Astrocystis thailandica,Camporesia sambuci,Clematidis italica,Colletotrichum menispermi,***,Comoclathris pimpinellae,Crassiparies quadrisporus,Cytospora salicicola,Diatrype thailandica,Dothiorella rhamni,Durotheca macrostroma,Farasanispora avicenniae,Halorosellinia rhizophorae,Humicola koreana,Hypoxylon lilloi,Kirschsteiniothelia tectonae,Lindgomyces okinawaensis,Longiostiolum tectonae,Lophiostoma pseudoarmatisporum,Moelleriella phukhiaoensis,***,Mucoharknessia anthoxanthi,Multilocularia bambusae,Multiseptospora thysanolaenae,Neophaeocryptopus cytisi,Ocellularia arachchigei,***,Ochronectria thailandica,Ophiocordyceps karstii,Parameliola acaciae,***,Parastagonospora cumpignensis,Pseudodidymosphaeria phlei,Polyplosphaeria thailandica,Pseudolachnella brevifusiformis,Psiloglonium macrosporum,Rhabdodiscus albodenticulatus,Rosellinia chiangmaiensis,Saccothecium rubi,Seimatosporium pseudocornii,***,Sigarispora ononidis and Towyspora *** combinations are provided for Eutiarosporella dactylidis(sexual morph described and illus trated)and Pseudocamarosporium ***,illustrations and/or reference specimens are designated for Aposphaeria corallinolutea,Cryptovalsa ampelina,Dothiorella vidmadera,Ophiocordyceps formosana,P

关键词： Ascomycota Basidiomycota Neocallimastigomycota Oomycota.Zygomycota Phylogeny Taxonomy New genus New species

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Lipopolysaccharide from Gut-Associated Lymphoid-Tissue-ResidentAlcaligenes faecalis: Complete Structure Determination and Chemical Synthesis of Its Lipid A

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Angewandte Chemie 2021年第18期133卷

作者： Dr. Atsushi Shimoyama Dr. Flaviana Di Lorenzo Haruki Yamaura Dr. Keisuke Mizote Dr. Angelo Palmigiano Molly D. Pither Dr. Immacolata Speciale Tomoya Uto Dr. Seiji Masui Dr. Luisa Sturiale Prof. Domenico Garozzo Dr. Koji Hosomi Dr. Naoko Shibata Dr. Kazuya Kabayama Prof. Yukari Fujimoto Prof. Alba Silipo Prof. Jun Kunisawa Prof. Hiroshi Kiyono Prof. Antonio Molinaro Prof. Koichi Fukase Department of Chemistry Graduate School of Science Osaka University 1-1 Machikaneyama Toyonaka Osaka 560-0043 Japan Project Research Center for Fundamental Sciences Osaka University 1-1 Machikaneyama Toyonaka Osaka 560-0043 Japan Department of Chemical Sciences and Task Force on Microbiome Studies University of Naples Federico II Via Cinthia 4 80126 Naples Italy CNR Institute for Polymers Composites and Biomaterials IPCB Via P. Gaifami 18 95126 Catania Italy Department of Chemical Sciences University of Naples Federico II Via Cinthia 4 80126 Naples Italy Laboratory of Vaccine Materials Center for Vaccine and Adjuvant Research and Laboratory of Gut Environmental System National Institutes of Biomedical Innovation Health and Nutrition Osaka 567-0085 Japan Faculty of Science and Engineering Waseda University 3-4-1 Okubo Shinjuku-ku Tokyo 169-8555 Japan Faculty of Science and Technology Keio University 3-14-1 Hiyoshi Kohoku-ku Yokohama Kanagawa 223-8522 Japan International Research and Development Center for Mucosal Vaccines The Institute of Medical Science The University of Tokyo 4–6-1 Shirokanedai Minato-ku Tokyo 108-8639 Japan

Alcaligenes faecalis is the predominant Gram-negative bacterium inhabiting gut-associated lymphoid tissues, Peyer's patches. We previously reported that an A. faecalis lipopolysaccharide (LPS) acted as a weak agonist for Toll-like receptor 4 (TLR4)/myeloid differentiation factor-2 (MD-2) receptor as well as a potent inducer of IgA without excessive inflammation, thus suggesting that A. faecalis LPS might be used as a safe adjuvant. In this study, we characterized the structure of both the lipooligosaccharide (LOS) and LPS from A. faecalis . We synthesized three lipid A molecules with different degrees of acylation by an efficient route involving the simultaneous introduction of 1- and 4′-phosphates. Hexaacylated A. faecalis lipid A showed moderate agonistic activity towards TLR4-mediated signaling and the ability to elicit a discrete interleukin-6 release in human cell lines and mice. It was thus found to be the active principle of the LOS/LPS and a promising vaccine adjuvant candidate.

关键词： glycolipids lipid A lipopolysaccharides oligosaccharides vaccines

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Obesity alters pathology and treatment response in inflammatory disease

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四川生理科学杂志 2022年第3期44卷 446-446页

作者： Sagar P Bapat NOMIS Center for Immunobiology and Microbial Pathogenesis The Salk Institute for Biological Studies La Jolla CA USA Gene Expression Laboratory The Salk Institute for Biological Studies La Jolla CA USA Medical Scientist Training Program University of California San Diego La Jolla CA USA Department of Laboratory Medicine University of California San Francisco San Francisco CA USA Department of Microbiology and Immunology University of California San Francisco San Francisco CA USA Diabetes Center University of California San Francisco San Francisco CA USA Medical Scientist Training Program University of California San Francisco CA USA Division of Pulmonary Critical Care Allergy and Sleep Department of Medicine University of California San Francisco San Francisco CA USA School of Pharmaceutical Sciences Xiamen University Xiamen China Department of Dermatology University of California San Diego La Jolla CA USA Department of Surgery University of California San Francisco San Francisco CA USA Department of Medicine University of California San Francisco San Francisco CA USA Sandler Asthma Basic Research Center University of California San Francisco San Francisco CA USA School of Medicine Wake Forest University Winston–Salem NC USA Department of Dermatology Icahn School of Medicine at Mount Sinai New York NY USA Lung Biology Center Department of Medicine University of California San Francisco San Francisco CA USA Department of Biomedical Science Graduate School Kyungpook National University Kyungpook National University Hospital Daegu South Korea Department of Dermatology University of California San Francisco San Francisco CA USA Department of Pathology University of California San Francisco San Francisco CA USA Department of Internal Medicine Division of Pulmonary Critical Care and Sleep Medicine University of Kentucky Lexington KY USA Pulmonary Critical Care Section Department of Medicine Veterans Affairs San Diego Hea

Decades of work have elucidated cytokine signalling and transcriptional pathways that control T cell differentiation and have led the way to targeted biologic therapies that are effective in a range of autoimmune,allergic and inflammatory *** evidence indicates that obesity and metabolic disease can also influence the immune system1-7,although the mechanisms and effects on immunotherapy outcomes remain largely ***,using two models of atopic dermatitis,we show that lean and obese mice mount markedly different immune *** converted the classical type 2 T helper(TH2)-predominant disease associated with atopic dermatitis to a more severe disease with prominent TH17 *** also observed divergent responses to biologic therapies targeting TH2 cytokines,which robustly protected lean mice but exacerbated disease in obese ***-cell RNA sequencing coupled with genome-wide binding analyses revealed decreased activity of nuclear receptor peroxisome proliferator-activated receptor-γ(PPARγ)in TH2 cells from obese mice relative to lean mice.

关键词： dermatitis inflammatory allergic

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Learning from learning machines: A new generation of AI technology to meet the needs of science

arXiv

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arXiv 2021年

作者： Pion-Tonachini, Luca Bouchard, Kristofer Martin, Hector Garcia Peisert, Sean Holtz, W. Bradley Aswani, Anil Dwivedi, Dipankar Wainwright, Haruko Pilania, Ghanshyam Nachman, Benjamin Marrone, Babetta L. Falco, Nicola Prabhat Arnold, Daniel Wolf-Yadlin, Alejandro Powers, Sarah Climer, Sharlee Jackson, Quinn Carlson, Ty Sohn, Michael Zwart, Petrus Kumar, Neeraj Justice, Amy Tomlin, Claire Jacobson, Daniel Micklem, Gos Gkoutos, Georgios V. Bickel, Peter J. Cazier, Jean-Baptiste Müller, Juliane Webb-Robertson, Bobbie-Jo Stevens, Rick Anderson, Mark Kreutz-Delgado, Ken Mahoney, Michael W. Brown, James B. Pattern Computer Inc. Friday HarborWA98250 United States Biosciences Area Lawrence Berkeley National Lab BerkeleyCA94803 United States Computational Research Division Lawrence Berkeley National Lab BerkeleyCA94720 United States Helen Wils Neuroscience Institute Redwood Center for Theoretical Neuroscience Uc Berkeley BerkeleyCA94720 United States Doe Agile BioFoundry Lawrence Berkeley National Laboratory BerkeleyCA94803 United States Joint BioEnergy Institute Lawrence Berkeley National Laboratory BerkeleyCA94803 United States Bcam Basque Center for Applied Mathematics Bilbao48009 Spain Computer Science University of California Davis DavisCA95616 United States Cenic La MiradaCA90638 United States Health Informatics University of California Davis School of Medicine SacramentoCA95817 United States Berkeley Institute for Data Science University of California Berkeley BerkeleyCA94720 United States Industrial Engineering and Operations Research University of California Berkeley BerkeleyCA94720 United States Environmental & Earth Sciences Area Lawrence Berkeley National Laboratory BerkeleyCA94803 United States Nuclear Engineering University of California Berkeley BerkeleyCA94720 United States Materials Science and Technology Division Los Alamos National Laboratory Los AlamosNM87545 United States Physics Division Lawrence Berkeley National Lab BerkeleyCA94720 United States Bioscience Division Los Alamos National Laboratory Los AlamosNM87545 United States Earth and Environmental Sciences Area Lawrence Berkeley National Lab BerkeleyCA94803 United States Energy Technologies Area Lawrence Berkeley National Lab BerkeleyCA94803 United States Computing and Computational Sciences Oak Ridge National Laboratory Oak RidgeTN37831 United States Industrial & Systems Engineering The University of Tennessee KnoxvilleTN37996 United States Department of Computer Science University of Missouri-Saint Louis St. LouisMO63121 United

We outline emerging opportunities and challenges to enhance the utility of AI for scientific discovery. The distinct goals of AI for industry versus the goals of AI for science create tension between identifying patterns in data versus discovering patterns in the world from data. If we address the fundamental challenges associated with "bridging the gap" between domain-driven scientific models and data-driven AI learning machines, then we expect that these AI models can transform hypothesis generation, scientific discovery, and the scientific process itself. © 2021, CC BY.

关键词： Learning systems

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Author Correction: Restoration of patterned vision with an engineered photoactivatable G protein-coupled receptor

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Nature communications 2018年第1期9卷 1112页

作者： Michael H Berry Amy Holt Joshua Levitz Johannes Broichhagen Benjamin M Gaub Meike Visel Cherise Stanley Krishan Aghi Yang Joon Kim Kevin Cao Richard H Kramer Dirk Trauner John Flannery Ehud Y Isacoff Department of Molecular and Cell Biology University of California Berkeley CA 94720 USA. Department of Medicine Oregon Health and Science University Portland OR 97239 USA. Department of Biochemistry Weill Cornell Medical College New York City New York 10024 USA. Department of Chemistry Ludwig-Maximilians-Universität München and Munich Center for Integrated Protein Science Butenandtstrasse 5-13 81377 München Germany. Laboratory of Protein Engineering Institut des Sciences et Ingénierie Chimiques Sciences de Base École Polytechnique Fédérale Lausanne 1015 Lausanne Switzerland. Department of Chemical Biology Max-Planck Institute for Medical Research Jahnstr. 29 69120 Heidelberg Germany. Department of Biosystems Science Engineering ETH Zürich Mattenstrasse 26 4058 Basel Switzerland. Helen Wills Neuroscience Institute University of California Berkeley CA 94720 USA. Biophysics Graduate Program University of California Berkeley CA 94720 USA. Department of Chemistry New York University New York City New York 10003 USA. School of Optometry University of California Berkeley CA 94720 USA. Department of Molecular and Cell Biology University of California Berkeley CA 94720 USA. ehud@berkeley.edu. Helen Wills Neuroscience Institute University of California Berkeley CA 94720 USA. ehud@berkeley.edu. Biophysics Graduate Program University of California Berkeley CA 94720 USA. ehud@berkeley.edu. Bioscience Division Lawrence Berkeley National Laboratory Berkeley CA 94720 USA. ehud@berkeley.edu.

Kevin J. Cao and Richard H. Kramer, who developed extended release with beta cyclodextrin, were inadvertently omitted from the author list and author contributions section of this Article. These errors have now been c... 详细信息

关键词： Molecular neuroscience Protein design Retina

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Corrigendum to "A novel vaccination strategy against Vibrio harveyi infection in Asian seabass (Lates calcarifer) with the aid of oxygen nanobubbles and chitosan" [Fish and Shellfish Immunol 149 (2024) 109557]

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Fish & shellfish immunology 2024年 154卷 110000页

作者： Nguyen Giang Thu Lan Ha Thanh Dong Nguyen Tien Vinh Krishna R Salin Saengchan Senapin Khaettareeya Pimsannil Sophie St-Hilaire Andrew P Shinn Channarong Rodkhum The International Graduate Program of Veterinary Science and Technology (VST) Faculty of Veterinary Science Chulalongkorn University Bangkok Thailand Center of Excellence in Fish Infectious Diseases (CE FID) Department of Veterinary Microbiology Faculty of Veterinary Science Chulalongkorn University Bangkok Thailand Aquaculture and Aquatic Resources Management Department of Food Agriculture and Bioresources School of Environment Resources and Development Asian Institute of Technology Pathum Thani Thailand. Aquaculture and Aquatic Resources Management Department of Food Agriculture and Bioresources School of Environment Resources and Development Asian Institute of Technology Pathum Thani Thailand. Electronic address: htdong@ait.ac.th. National Center for Genetic Engineering and Biotechnology (BIOTEC) National Science and Technology Development Agency (NSTDA) Pathum Thani Thailand Fish Heath Platform Center of Excellence for Shrimp Molecular Biology and Biotechnology (Centex Shrimp) Faculty of Science Mahidol University Bangkok Thailand. Department of Infectious Diseases and Public Health Jockey Club College of Veterinary Medicine and Life Sciences City University of Hong Kong Kowloon Tong Hong Kong. INVE Aquaculture (Thailand) 471 Bond Street Bangpood Pakkred Nonthaburi 11120 Thailand. Center of Excellence in Fish Infectious Diseases (CE FID) Department of Veterinary Microbiology Faculty of Veterinary Science Chulalongkorn University Bangkok Thailand. Electronic address: Channarong.R@chula.ac.th.

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Author Correction: Nitrogen and phosphorus constrain the CO2 fertilization of global plant biomass

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Nature Climate Change 2020年第7期10卷 696-697页

作者： César Terrer Robert B. Jackson I. Colin Prentice Trevor F. Keenan Christina Kaiser Sara Vicca Joshua B. Fisher Peter B. Reich Benjamin D. Stocker Bruce A. Hungate Josep Peñuelas Ian McCallum Nadejda A. Soudzilovskaia Lucas A. Cernusak Alan F. Talhelm Kevin Van Sundert Shilong Piao Paul C. D. Newton Mark J. Hovenden Dana M. Blumenthal Yi Y. Liu Christoph Müller Klaus Winter Christopher B. Field Wolfgang Viechtbauer Caspar J. Van Lissa Marcel R. Hoosbeek Makoto Watanabe Takayoshi Koike Victor O. Leshyk H. Wayne Polley Oskar Franklin Department of Earth System Science Stanford University Stanford USA Institut de Ciència i Tecnologia Ambientals Universitat Autònoma de Barcelona Barcelona Spain Ecosystems Services and Management Program International Institute for Applied Systems Analysis Laxenburg Austria Woods Institute for the Environment and Precourt Institute for Energy Stanford University Stanford USA AXA Chair Programme in Biosphere and Climate Impacts Department of Life Sciences Imperial College London Silwood Park Campus Ascot UK Department of Biological Sciences Macquarie University North Ryde Australia Department of Earth System Science Tsinghua University Beijing China Department of Environmental Science Policy and Management UC Berkeley Berkeley USA Climate and Ecosystem Sciences Division Lawrence Berkeley National Laboratory Berkeley USA Department of Microbiology and Ecosystem Science Division of Terrestrial Ecosystem Research Faculty of Life Sciences University of Vienna Vienna Austria Evolution and Ecology Program International Institute for Applied Systems Analysis Laxenburg Austria Centre of Excellence PLECO (Plants and Ecosystems) Biology Department University of Antwerp Wilrijk Belgium Jet Propulsion Laboratory California Institute of Technology Pasadena USA Joint Institute for Regional Earth System Science and Engineering University of California at Los Angeles Los Angeles USA Department of Forest Resources University of Minnesota St. Paul USA Hawkesbury Institute for the Environment Western Sydney University Penrith Australia CREAF Cerdanyola del Vallès Spain Center for Ecosystem Science and Society Northern Arizona University Flagstaff USA Department of Biological Sciences Northern Arizona University Flagstaff USA CSIC Global Ecology Unit CREAF-CEAB-UAB Bellaterra Spain Environmental Biology Department Institute of Environmental Sciences Leiden University Leiden the Netherlands College of Marine and Environmental Sciences James Cook University Cairns

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282

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Cytokine 2013年第3期63卷 310-310页

作者： Elia D. Tait Wojno Mario Noti Brian S. Kim Mark C. Siracusa Paul R. Giacomin Meera G. Nair Alain J. Benitez Kathryn R. Ruymann Amanda B. Muir David A. Hill Kudakwashe R. Chikwava Amin E. Moghaddam Quentin J. Sattentau Aneesh Alex Chao Zhou Paul Menard-Katcher Masato Kubo Kazushige Obata-Ninomiya Hajime Karasuyama Michael R. Comeau David Artis Department of Microbiology University of Pennsylvania Philadelphia PA USA Institute for Immunology Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Queensland Tropical Health Alliance and School of Public Health and Tropical Medicine James Cook University Cairns Australia Division of Gastroenterology Hepatology and Nutrition Children’s Hospital of Philadelphia Philadelphia PA USA Department of Pediatrics Division of Allergy and Immunology Children’s Hospital of Philadelphia Philadelphia PA USA Department of Pathology and Laboratory Medicine Children’s Hospital of Philadelphia Philadelphia PA USA The Sir William Dunn School of Pathology The University of Oxford Oxford UK Department of Electrical and Computer Engineering Lehigh University Bethlehem PA USA Center for Photonics and Nanoelectronics Lehigh University BethlehemPA USA Bioengineering Program Lehigh University Bethlehem PA USA Division of Gastroenterology Hospital of the University of Pennsylvania Philadelphia PA USA Laboratory for Signal Network Research Center for Allergy and Immunology RIKEN Yokohama Institute Yokohama Japan Division of Molecular Pathology Research Institute for Biological Science Tokyo University of Science Chiba Japan Department of Immune Regulation Tokyo Medical and Dental University Graduate School Tokyo Japan JST CREST Tokyo Medical and Dental University Graduate School Tokyo Japan Inflammation Research Amgen Inc. Seattle WA USA Department of Pathobiology School of Veterinary Medicine University of Pennsylvania Philadelphia PA USA

Eosinophilic esophagitis (EoE) is a food allergy-associated disease characterized by esophageal eosinophilia and associated inflammation. EoE has become increasingly common in industrialized countries. However, current management strategies, such as treatment with swallowed steroids and dietary restrictions, are nonspecific or negatively impact the quality of life of EoE patients. In addition, use of more specific therapies that target immunoglobulin E (IgE) and interleukin (IL)-5 have been largely unsuccessful in ameliorating EoE. Thus, there is an urgent need to identify novel, specific immunological pathways that underlie the pathogenesis of EoE that could be targeted to treat this disease. Recently, a genome-wide association study identified that EoE is associated with a gain-of-function polymorphism in the gene that encodes thymic stromal lymphopoietin (TSLP). TSLP is an IL-7 family member cytokine that promotes allergic inflammation by eliciting T helper type 2 cytokine responses, IgE production, and the expansion of a distinct population of basophils . However, whether TSLP directly promotes allergic inflammation in the esophagus and the mechanisms by which TSLP might contribute to the pathogenesis of EoE remain unknown. Here, we describe a new murine model of experimental EoE-like disease that was used to investigate the role of TSLP in allergic inflammation of the esophagus. Murine experimental EoE-like disease developed independently of IgE but was dependent on TSLP-elicited basophils. Critically, therapeutic antibody-mediated neutralization of TSLP or depletion of basophil populations ameliorated established EoE-like disease in mice. Finally, elevated TSLP levels and exaggerated basophil responses were observed in esophageal biopsies from EoE patients, and a gain-of-function polymorphism in TSLP correlated with increased basophil responses in patients with EoE. Together, these data indicate that TSLP-elicited basophil responses may play a key role in medi

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The autocrine glycosylated-GREM1 interacts with TGFB1 to suppress TGFβ/BMP/SMAD-mediated EMT partially by inhibiting MYL9 transactivation in urinary carcinoma

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Cellular oncology (Dordrecht, Netherlands) 2023年第4期46卷 933-951页

作者： Ti-Chun Chan Cheng-Tang Pan Hsin-Yu Hsieh Pichpisith Pierre Vejvisithsakul Ren-Jie Wei Bi-Wen Yeh Wen-Jeng Wu Lih-Ren Chen Meng-Shin Shiao Chien-Feng Li Yow-Ling Shiue Department of Medical Research Chi-Mei Medical Center Tainan 71004 Taiwan. National Institute of Cancer Research National Health Research Institutes Tainan 71004 Taiwan. Institute of Precision Medicine College of Medicine National Sun Yat-Sen University Kaohsiung 80424 Taiwan. Department of Mechanical and Electro-Mechanical Engineering National Sun Yat-Sen University Kaohsiung 80424 Taiwan. Institute of Advanced Semiconductor Packaging and Testing College of Semiconductor and Advanced Technology Research National Sun Yat-Sen University Kaohsiung 80424 Taiwan. Institute of Biomedical Sciences College of Medicine National Sun Yat-Sen University Kaohsiung 80424 Taiwan. Program in Translational Medicine Faculty of Medicine Ramathibodi Hospital Mahidol University Bangkok 10400 Thailand. Department of Pathology Kaohsiung Armed Forces General Hospital Kaohsiung 80284 Taiwan. Institute of Medical Science and Technology School of Medicine National Sun Yat-Sen University Kaohsiung 80424 Taiwan. Department of Medical Laboratory Sciences and Biotechnology Fooyin University Kaohsiung 83102 Taiwan. Department of Urology School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung 80708 Taiwan. Department of Urology Kaohsiung Medical University Hospital Kaohsiung 80708 Taiwan. Graduate Institute of Clinical Medicine College of Medicine Kaohsiung Medical University Kaohsiung 80708 Taiwan. Regenerative Medicine and Cell Therapy Research Center Kaohsiung Medical University Kaohsiung 80708 Taiwan. Division of Physiology Livestock Research Institute Tainan 71246 Taiwan. Research Center Faculty of Medicine Ramathibodi Hospital Mahidol University Bangkok 10400 Thailand. Department of Medical Research Chi-Mei Medical Center Tainan 71004 Taiwan. angelo.p@yahoo.com.tw. National Institute of Cancer Research National Health Research Institutes Tainan 71004 Taiwan. angelo.p@yahoo.com.tw. Institute of Precision Medicine College of Medicine Nat

PURPOSE:Urothelial carcinoma (UC) is a common disease in developed counties. This study aimed to identify autocrine roles and signaling pathways of gremlin 1, DAN family BMP antagonist (GREM1), which inhibits tumor growth and epithelial-mesenchymal transition (EMT) in UC. METHODS:systematic in vitro and in vivo studies using genetic engineering, different urinary bladder urothelial carcinoma (UBUC)-derived cell lines, and mouse models were performed, respectively. Further, primary upper tract urothelial carcinoma (UTUC) and UBUC specimens were evaluated by immunohistochemistry. RESULTS:GREM1 protein levels conferred better disease-specific and metastasis-free survival rates and played an independent prognostic factor in UTUC and UBUC. Hypermethylation is the primary cause of low GREM1 levels. In different UBUC-derived cell lines, the autocrine/secreted and glycosylated GREM1 interacted with transforming growth factor beta 1 (TGFB1) and inhibited TGFβ/BMP/SMAD signaling and myosin light chain 9 (MYL9) transactivation, subsequently cell proliferation and epithelial-mesenchymal transition (EMT). Secreted and glycosylated GREM1 also suppressed tumor growth, metastasis, and MYL9 levels in the mouse model. Instead, cytosolic GREM1 promoted cell proliferation and EMT by activating the tumor necrosis factor (TNF)/AKT/nuclear factor kappa B (NFκB) axis. CONCLUSIONS:Clinical associations, animal models, and in vitro indications provided solid evidence to show that the epithelial autocrine GREM1 is a novel tumor suppressor in UCs. The glycosylated-GREM1 hampered cell proliferation, migration, invasion, and in vitro angiogenesis through interaction with TGFB1 to inactivate TGFβ/BMP/SMAD-mediated EMT in an autocrine manner.

关键词： Autocrine Epithelial-mesenchymal transition GREM1 TGFβ Urothelial carcinoma

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Adverse events following the first, second and third doses of a COVID-19 vaccine in hemodialysis patients

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Renal failure 2023年第1期45卷 2172432页

作者： Mei-Fen Pai Kuei-Ting Tung Shih-Ping Hsu Yu-Sen Peng Wan-Yu Lin Ju-Yeh Yang Hon-Yen Wu Yen-Ling Chiu Kai-Hsiang Shu Wan-Chuan Tsai Division of Nephrology Department of Internal Medicine Far Eastern Memorial Hospital New Taipei City Taiwan. Department of Internal Medicine National Taiwan University Hospital and College of Medicine Taipei City Taiwan. School of Life Science National Taiwan Normal University Taipei City Taiwan. Department of Applied Cosmetology Lee-Ming Institute of Technology New Taipei City Taiwan. Department of Electrical Engineering Yuan Ze University Taoyuan City Taiwan. Institute of Epidemiology and Preventive Medicine College of Public Health National Taiwan University Taipei City Taiwan. Center for General Education Lee-Ming Institute of Technology New Taipei City Taiwan. Faculty of Medicine School of Medicine National Yang-Ming University Taipei City Taiwan. Graduate Program in Biomedical Informatics Yuan Ze University Taoyuan City Taiwan.

BACKGROUND:This study aimed to identify adverse events following the first three doses of COVID-19 vaccines in hemodialysis (HD) patients. Risk factors associated with postvaccination adverse events were explored. METHODS:Postvaccination adverse events in 438 HD patients who received 3 doses of COVID-19 vaccines were prospectively assessed. The adverse events among three doses were compared using generalized linear mixed models. Factors associated with adverse events were assessed with multivariate analyses. RESULTS:The vast majority of participants received Oxford/AstraZeneca ChAdOx1 as their first two doses and Moderna mRNA-1273 as their third dose. Overall, 79%, 50% and 84% of the participants experienced at least one adverse event after their first, second, and third doses, respectively. These adverse events were mostly minor, short-lived and less than 5% reported daily activities being affected. Compared with the first dose, the second dose caused a lower rate of adverse events. Compared with the first dose, the third dose elicited a higher rate of injection site reactions and a lower rate of systemic reactions. Multivariate analyses showed that every 10-year increase of age (odds ratio 0.67, 95% confidence intervals 0.57-0.79) was associated with decreased risk of adverse events, while female sex (2.82, 1.90-4.18) and arteriovenous fistula (1.73, 1.05-2.84) were associated with increased risk of adverse events. Compared with Oxford/AstraZeneca ChAdOx1, Moderna mRNA-1273 was associated with an increased risk of injection site reactions. CONCLUSIONS:COVID-19 vaccination was well tolerated in HD patients. Age, sex, dialysis vascular access and vaccine types were associated with postvaccination adverse events.

关键词： COVID-19 ChAdOx1 Hemodialysis adverse event mRNA-1273 vaccination

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