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Author Correction: A microfluidic assay for the quantification of the metastatic propensity of breast cancer specimens

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Nature biomedical engineering 2025年第2期9卷 285页

作者： Christopher L Yankaskas Keyata N Thompson Colin D Paul Michele I Vitolo Panagiotis Mistriotis Ankit Mahendra Vivek K Bajpai Daniel J Shea Kristen M Manto Andreas C Chai Navin Varadarajan Aikaterini Kontrogianni-Konstantopoulos Stuart S Martin Konstantinos Konstantopoulos Department of Chemical and Biomolecular Engineering The Johns Hopkins University Baltimore MD USA. Johns Hopkins Institute for NanoBioTechnology The Johns Hopkins University Baltimore MD USA. Marlene and Stewart Greenebaum National Cancer Institute Comprehensive Cancer Center University of Maryland School of Medicine Baltimore MD USA. Graduate Program in Molecular Medicine University of Maryland School of Medicine Baltimore MD USA. Department of Physiology University of Maryland School of Medicine Baltimore MD USA. Department of Chemical and Biomolecular Engineering University of Houston Houston TX USA. Department of Chemical and Systems Biology Stanford University Stanford CA USA. Department of Biochemistry and Molecular Biology University of Maryland School of Medicine Baltimore MD USA. Department of Chemical and Biomolecular Engineering The Johns Hopkins University Baltimore MD USA. konstant@jhu.edu. Johns Hopkins Institute for NanoBioTechnology The Johns Hopkins University Baltimore MD USA. konstant@jhu.edu. Department of Biomedical Engineering The Johns Hopkins University Baltimore MD USA. konstant@jhu.edu. Department of Oncology The Johns Hopkins University School of Medicine Baltimore MD USA. konstant@jhu.edu.

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Self-Aware Smart Products: Systematic Literature Review, Conceptual Design and Prototype Implementation

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Procedia Manufacturing 2017年 11卷 1471-1480页

作者： Filho, Marcelo Feliciano Liao, Yongxin Loures, Eduardo Rocha Canciglieri, Osiris Graduate Program in Industrial and Systems Engineering (PPGEPS) Pontifical University Catholic of Paraná Curitiba 80215-901 Brazil

The fourth industrial revolution makes more effective use of data generated during manufacturing processes and creates a more interconnected manufacturing network. The data stored inside a product can be updated, analyzed and protected throughout its life cycle. It is currently becoming a reality to speed up the modern mass-customization. The aim of this paper is firstly to explore the state of art about smart products through a systematic literature review. Second, to design a self-aware smart product in a smart factory production environment based on the review findings. Finally, to turn the conceptual design into a prototype implementation. © 2017

关键词： CPS Industrie 4.0 Intelligent Products IoT RFID Smart Factory Smart Products Systematic Literature Review

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Impact of Scheduling Policies on the Performance of an Additive Manufacturing Production System

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Procedia Manufacturing 2019年 39卷 447-456页

作者： Maaz Saleem Kapadia Binil Starly Alec Thomas Reha Uzsoy Donald Warsing Graduate Program in Operations Research North Carolina State University 2500 Stinson Dr Raleigh NC 27607 USA Edward P.Fitts Department of Industrial and Systems Engineering North Carolina State University 111 Lampe Dr Raleigh NC 27607 USA Poole College of Management North Carolina State University 2801 Founders Dr Raleigh NC 27695 USA

We study the impact of scheduling policies on the cycle time and throughput of an Additive Manufacturing (AM) facility. Orders for irregularly shaped parts with specified due dates and surface quality requirements arrive randomly at the facility. The parts are fabricated in one of several AM build chambers, followed by post-processing operations based on surface finishing requirements. We combine a part placement heuristic with different scheduling policies (FIFO, Earliest Due Date) to allocate parts to AM build chambers and lay out the parts within the chambers to approximately optimize delivery performance. Simulation experiments using an Iterative Optimization-based Simulation (IOS) model integrating a simulation engine (implemented in SIMIO) with a computational engine (implemented in MATLAB) show that the scheduling policies have a significant impact on cycle time and order lateness. Selection and peer review under the responsibility of ICPR25 International Scientific & Advisory and Organizing Committee members.

关键词： Iterative Optimization-based Simulation Additive Manufacturing Genetic Algorithm

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An atlas of dynamic chromatin landscapes in mouse fetal development (vol 583, pg 744, 2020)

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NATURE 2021年第7842期589卷 E4-E4页

作者： Gorkin, David U. Barozzi, Iros Zhao, Yuan Zhang, Yanxiao Huang, Hui Lee, Ah Young Li, Bin Chiou, Joshua Wildberg, Andre Ding, Bo Zhang, Bo Wang, Mengchi Strattan, J. Seth Davidson, Jean M. Qiu, Yunjiang Afzal, Veena Akiyama, Jennifer A. Plajzer-Frick, Ingrid Novak, Catherine S. Kato, Momoe Garvin, Tyler H. Pham, Quan T. Harrington, Anne N. Mannion, Brandon J. Lee, Elizabeth A. Fukuda-Yuzawa, Yoko He, Yupeng Preissl, Sebastian Chee, Sora Han, Jee Yun Williams, Brian A. Trout, Diane Amrhein, Henry Yang, Hongbo Cherry, J. Michael Wang, Wei Gaulton, Kyle Ecker, Joseph R. Shen, Yin Dickel, Diane E. Visel, Axel Pennacchio, Len A. Ren, Bing Ludwig Institute for Cancer Research La Jolla CA USA Center for Epigenomics University of California San Diego School of Medicine La Jolla CA USA Bioinformatics and Systems Biology Graduate Program University of California San Diego La Jolla CA USA Biomedical Sciences Graduate Program University of California San Diego School of Medicine La Jolla CA USA Department of Cellular and Molecular Medicine University of California San Diego School of Medicine La Jolla CA USA Institute of Genomic Medicine University of California San Diego School of Medicine La Jolla CA USA Moores Cancer Center University of California San Diego School of Medicine La Jolla CA USA Environmental Genomics and Systems Biology Division Lawrence Berkeley National Laboratory Berkeley CA USA Department of Surgery and Cancer Imperial College London London UK US Department of Energy Joint Genome Institute Berkeley CA USA School of Natural Sciences University of California Merced Merced CA USA Comparative Biochemistry Program University of California Berkeley Berkeley CA USA Genomic Analysis Laboratory Salk Institute for Biological Studies La Jolla CA USA Department of Pediatrics University of California San Diego School of Medicine La Jolla CA USA Department of Biochemistry and Molecular Biology Penn State School of Medicine Hershey PA USA Stanford University School of Medicine Department of Genetics Stanford CA USA Howard Hughes Medical Institute Salk Institute for Biological Studies La Jolla CA USA Division of Biology and Biological Engineering California Institute of Technology Pasadena CA USA Institute for Human Genetics and University of California San Francisco San Francisco CA USA Department of Neurology University of California San Francisco San Francisco CA USA

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Author Correction: Single-cell transcriptomics uncovers EGFR signaling-mediated gastric progenitor cell differentiation in stomach homeostasis

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Nature communications 2023年第1期14卷 6540页

作者： Hitomi Takada Yohei Sasagawa Mika Yoshimura Kaori Tanaka Yoshimi Iwayama Tetsutaro Hayashi Ayako Isomura-Matoba Itoshi Nikaido Akira Kurisaki Laboratory of Stem Cell Technologies Graduate School of Science and Technology Nara Institute of Science and Technology Takayama-cho Ikoma Nara Japan. Laboratory for Bioinformatics Research RIKEN Center for Biosystems Dynamics Research Wako Saitama Japan. Department of Functional Genome Informatics Biological Data Science Medical Research Institute Tokyo Medical and Dental University Bunkyo Tokyo Japan. Laboratory for Bioinformatics Research RIKEN Center for Biosystems Dynamics Research Wako Saitama Japan. itoshi.nikaido@riken.jp. Department of Functional Genome Informatics Biological Data Science Medical Research Institute Tokyo Medical and Dental University Bunkyo Tokyo Japan. itoshi.nikaido@riken.jp. Master's/Doctoral Program in Life Science Innovation (Bioinformatics) Degree Programs in Systems and Information Engineering Graduate School of Science and Technology University of Tsukuba Tsukuba Ibaraki Japan. itoshi.nikaido@riken.jp. Laboratory of Stem Cell Technologies Graduate School of Science and Technology Nara Institute of Science and Technology Takayama-cho Ikoma Nara Japan. akikuri@bs.naist.jp.

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Big Data Governance for Building A Smart Cities

Big Data Governance for Building A Smart Cities

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International Conference on ICT For Smart Society (ICISS)

作者： Novan Zulkarnain Raymond Kosala Benny Ranti Suhono Harso Supangkat Computer Science Department BINUS Graduate Program Doctor of Computer Science Information Systems Department Bina Nusantara University Jakarta Indonesia Computer Science Department Bina Nusantara University Jakarta Indonesia Computer Science Department Universitas Indonesia Depok Indonesia School of Electrical and Informatics Engineering Institute of Technology Bandung Bandung Indonesia

There have been many studies conducted related to Smart City, IT Governance and Big Data. In this study aims to find out how the relationship between the three and how to form a framework to explain it. The methodology used is qualitative by looking for some literature on smart city framework, IT Governance framework, and a Big Data framework. From these results, an overall picture of the relationship between the three is concluded, where Big Data has a role in IT Governance. and also the relationship of IT Governance to the realization of Smart City. And the final results of this study produce a framework to explain the relationship between Smart City, IT Governance and Big Data.

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Effect of Movement on Positioning Accuracy in a Transponder-based Acoustical Positioning

Effect of Movement on Positioning Accuracy in a Transponder-...

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Regional Conference on Acoustics and Vibration 2017, RECAV 2017

作者： Iwaya, Hirokazu Ogiso, Satoki Mizutani, Koichi Ebihara, Tadashi Wakatsuki, Naoto Graduate School of Systems and Information Engineering University of Tsukuba 1-1-1 Tennodai Tsukuba Ibaraki305-8573 Japan Ph. D. Program in Empowerment Informatics School of Integrative and Global Majors University of Tsukuba 1-1-1 Tennodai Tsukuba Ibaraki305-8573 Japan Faculty of Engineering Information and Systems University of Tsukuba 1-1-1 Tennodai Tsukuba Ibaraki305-8573 Japan

A transponder-based positioning method using audible sounds for a large-scale area positioning has been proposed by the authors. The proposed method has two characteristics;it employs audible sounds instead of ultrasounds to measure long distance by using audible sounds, and it achieves positioning without clock synchronization among devices which is required additional equipment such as radio wave. However, positioning of the moving object (terminal) is still challenging because the proposed method requires longer measurement time than other methods since it measures the round-trip time of flight (TOF) among the terminal and the anchors (transponders). In this paper, we evaluated the effect of the terminal movement on positioning in simulations and experiments. From simulations and experimental results, it was found that the effect of Doppler and the terminal movement cause random error and offset in TOF/distance, respectively. Consequently, it was found that our proposed method is sensitive to the terminal movement. © Published under licence by IOP Publishing Ltd.

关键词： Transponders

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IoT-Based Architecture for Data Analytics of Arboviruses in Smart Cities

IoT-Based Architecture for Data Analytics of Arboviruses in ...

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IEEE Symposium on Computers and Communications

作者： Priscylla da S. Tavares Emanuel B. Rodrigues Group of Computer Networks Software Engineering and Systems (GREat) Graduate Program in Computer Science (MDCC) Federal University of Ceará (UFC) Fortaleza Brazil

With the progress of sensor technologies, there has been an increase in the number of connected computing devices capable of collecting information and interacting with the environment in which they are inserted, forming the basis of the Internet of Things (IoT). Such devices enable the development of new applications capable of making cities more intelligent, providing improvements to society and urban infrastructure. As a result of the interaction between different applications, there is a large set of data, from which useful knowledge can be extracted. An important problem to be faced is the recurrent occurrence of arbovirus outbreaks in big cities with tropical climate. This research proposes an architecture capable of aggregating data from different types of IoT devices, and manipulating them using data analytics techniques to assist the surveillance of arbovirus outbreaks. As an example of case study, we present an exploratory analysis of climatology data and cases of arbovirus diseases in the city of Fortaleza, Ceara, Brazil, between the years of 2011 and 2017.

关键词： Internet of Things Data analytics Health care Smart city

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Spatiotemporal dynamics of ecosystem fires and biomass burning-induced carbon emissions in China over the past two decades

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Geography and Sustainability 2020年第1期1卷 47-58页

作者： Anping Chen Rongyun Tang Jiafu Mao Chao Yue Xiran Li Mengdi Gao Xiaoying Shi Mingzhou Jin Daniel Ricciuto Sam Rabin Phillippe Ciais Shilong Piao Department of Biology Colorado State UniversityFort CollinsCO 80523USA Graduate Degree Program in Ecology Colorado State UniversityFort CollinsCO 80523USA Department of Industrial and Systems Engineering University of TennesseeKnoxvilleTN 37996USA Environmental Sciences Division and Climate Change Science Institute Oak Ridge National LaboratoryOak RidgeTN 37831USA State Key Laboratory of Soil Erosion and Dryland Farming on the Loess Plateau Northwest Agriculture&Forestry UniversityYanglingShanxi 712100China College of Urban and Environmental Sciences Central China Normal UniversityWuhanHubei 430079China Sino-French Institute for Earth System Science College of Urban and Environmental SciencesPeking UniversityBeijing 100871China Atmospheric Environmental Research(IMK-IFU) Institute of Meteorology and Climate ResearchKarlsruhe Institute of Technology(KIT)Kreuzeckbahnstraße 19Garmisch-Partenkirchen 82467Germany LSCE UMR CEA-CNRSBat.709CEL’Orme des MerisiersGif-sur-Yvette 91191France

Fire is a major type of disturbance that has important influences on ecosystem dynamics and carbon *** our understanding of ecosystem fires and their carbon cycle consequences is still limited,largely due to the difficulty of large-scale fire monitoring and the complex interactions between fire,vegetation,climate,and anthropogenic ***,using data from satellite-derived fire observations and ecosystem model simulations,we performed a comprehensive investigation of the spatial and temporal dynamics of China’s ecosystem fire disturbances and their carbon emissions over the past two decades(1997–2016).Satellite-derived results showed that on average about 3.47-4.53×10^(4) km^(2) of the land was burned annually during the past two decades,among which annual burned forest area was about 0.81-1.25×10^(4) km^(2),accounting for 0.33-0.51%of the forest area in *** burning emitted about 23.02 TgC per *** to satellite products,simulations from the Energy Exascale Earth System Land Model(ELM)strongly overestimated China’s burned area and fire-induced carbon *** burned area and fire-induced carbon emissions were high for boreal forest in Northeast China’s Daxing’anling region and subtropical dry forest in South Yunnan,as revealed by both the satellite product and the model *** results suggest that climate and anthropogenic factors play critical roles in controlling the spatial and seasonal distribution of China’s ecosystem fire *** findings highlight the importance of multiple complementary approaches in assessing ecosystem fire disturbance and its carbon *** studies are required to improve the methods of observing and modelling China’s ecosystem fire disturbances,which will provide valuable information for fire management and ecosystem sustainability in an era when both human activities and the natural environment are rapidly changing.

关键词： Fire emission Burned area Fire models China

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Influence of inhibitory synapses on the criticality of excitable neuronal networks

arXiv

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arXiv 2020年

作者： Borges, F.S. Protachevicz, P.R. Santos, V. Santos, M.S. Gabrick, E.C. Iarosz, K.C. Lameu, E.L. Baptista, M.S. Caldas, I.L. Batista, A.M. Center for Mathematics Computation and Cognition Federal University of ABC São Bernardo do CampoSP09606-045 Brazil Graduate Program in Science - Physics State University of Ponta Grossa Ponta Grossa PR84030-900 Brazil Institute of Physics University of São Paulo São PauloSP05508-900 Brazil Faculdade de Telêmaco Borba Telêmaco BorbaPR84266-010 Brazil Graduate Program in Chemical Engineering Federal University of Technology Paraná Ponta Grossa PR84016-210 Brazil Cell Biology and Anatomy Department University of Calgary AB T2N 4N1 CalgaryAB Canada Institute for Complex Systems and Mathematical Biology University of Aberdeen AberdeenScotlandAB24 3UE United Kingdom Department of Mathematics and Statistics State University of Ponta Grossa Ponta Grossa PR84030-900 Brazil

In this work, we study the dynamic range of a neuronal network of excitable neurons with excitatory and inhibitory synapses. We obtain an analytical expression for the critical point as a function of the excitatory and inhibitory synaptic intensities. We also determine an analytical expression that gives the critical point value in which the maximal dynamic range occurs. Depending on the mean connection degree and coupling weights, the critical points can exhibit ceasing or ceaseless dynamics. However, the dynamic range is equal in both cases. We observe that the external stimulus mask some effects of self-sustained activity (ceaseless dynamic) in the region where the dynamic range is calculated. In these regions, the firing rate is the same for ceaseless dynamics and ceasing activity. Furthermore, we verify that excitatory and inhibitory inputs are approximately equal for a network with a large number of connections, showing excitatory-inhibitory balance as reported experimentally. Copyright © 2020, The Authors. All rights reserved.

关键词： Dynamics

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