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2023 Conference on Lasers and Electro-Optics, CLEO 2023

作者： Chen, Wei-Ju Liao, En-Yu Tai, Tsung-Ming Liao, Yi-Hua Sun, Chi-Kuang Lee, Cheng-Kuang See, Simon Chen, Hung-Wen International Intercollegiate Ph.D. Program National Tsing Hua University Hsinchu Taiwan Department of Electrical Engineering Graduate Institute of Photonics and Optoelectronics National Taiwan University Taipei Taiwan NVIDIA AI Technology Center NVIDIA Taipei Taiwan Department of Dermatology National Taiwan University Hospital College of Medicine National Taiwan University Taipei Taiwan Institute of Photonics Technologies National Tsing Hua University Hsinchu Taiwan

This work proposes an unsupervised deep learning-based image translation from Harmonic generation microscopy (HGM) to widely used H&E-stained images. The proposed methodology is promising and hopefully will facili... 详细信息

ISBN: (纸本)9781957171258

关键词： Deep learning

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Glucose-mediated mitochondrial reprogramming by cholesterol export at TM4SF5-enriched mitochondria-lysosome contact sites

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Cancer Communications 2024年第1期44卷 47-75页

作者： Ji Eon Kim So-Young Park Chulhwan Kwak Yoonji Lee Dae-Geun Song Jae Woo Jung Haesong Lee Eun-Ae Shin Yangie Pinanga Kyung-hee Pyo Eun Hae Lee Wonsik Kim Soyeon Kim Chang-Duck Jun Jeanho Yun Sun Choi Hyun-Woo Rhee Kwang-Hyeon Liu Jung Weon Lee Department of Pharmacy College of PharmacySeoul National UniversitySeoulRepublic of Korea Research Institute of Pharmaceutical Sciences College of PharmacySeoul National UniversitySeoulRepublic of Korea BK21 FOUR Community-Based Intelligent Novel Drug Discovery Education Unit College of Pharmacy and Research Institute of Pharmaceutical SciencesKyungpook National UniversityDaeguRepublic of Korea Department of Chemistry Seoul National UniversitySeoulRepublic of Korea College of Pharmacy Chung-Ang UniversitySeoulRepublic of Korea Natural Product Informatics Research Center Korea Institute of Science and Technology(KIST)Gangneung-siGangwon-doRepublic of Korea School of Life Sciences Gwangju Institute of Science and Technology(GIST)GwangjuRepublic of Korea Department of Biochemistry College of MedicineDong-A UniversityBusanRepublic of Korea Global AI Drug Discovery Center College of Pharmacy and Graduate School of Pharmaceutical SciencesEwha Womans UniversitySeoulRepublic of Korea Interdisciplinary Program in Genetic Engineering Seoul National UniversitySeoulRepublic of Korea

Background:Transmembrane 4 L six family member 5(TM4SF5)translocates subcellularly and functions metabolically,although it is unclear how intracellu-lar TM4SF5 translocation is linked to metabolic *** is thus of interests to understand how the traffic dynamics of TM4SF5 to subcellular endosomal membranes are correlated to regulatory roles of ***:Here,we explored the metabolic significance of TM4SF5 localization at mitochondria-lysosome contact sites(MLCSs),using in vitro cells and in vivo animal systems,via approaches by immunofluorescence,proximity labelling based proteomics analysis,organelle reconstitution ***:Upon extracellular glucose repletion following depletion,TM4SF5 became enriched at MLCSs via an interaction between mitochondrial FK506-binding protein 8(FKBP8)and lysosomal *** labeling showed molecular clustering of phospho-dynamic-related protein I(DRP1)and certain mitophagy receptors at TM4SF5-enriched MLCSs,leading to mitochondrial fis-sion and ***4SF5 bound NPC intracellular cholesterol transporter 1(NPC1)and free cholesterol,and mediated export of lysosomal cholesterol to mitochondria,leading to impaired oxidative phosphorylation but intact tri-carboxylic acid(TCA)cycle andβ-*** mouse models,hepatocyte Tm4sf5 promoted mitophagy and cholesterol transport to mitochondria,both with positive relations to liver ***:Our findings suggested that TM4SF5-enriched MLCSs regu-late glucose catabolism by facilitating cholesterol export for mitochondrial reprogramming,presumably while hepatocellular carcinogenesis,recapitulating aspects for hepatocellular carcinoma metabolism with mitochondrial repro-gramming to support biomolecule synthesis in addition to glycolytic energetics.

关键词： cholesterol fluorescent imaging glucose catabolism hepatocellular carcinogenesis mem-brane contact sites mitochondria function mitophagy oxidative phosphorylation protein-protein interaction tetraspanin

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The path toward 500 um depletion of AstroPix, a pixelated silicon HVCMOS sensor for space and EIC

arXiv

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arXiv 2024年

作者： Steinhebel, Amanda L. Ott, Jennifer Kroger, Olivia Caputo, Regina Fadeyev, Vitaliy Affolder, Anthony Affolder, Kirsten Deshmukh, Aware Striebig, Nicolas Jadhav, Manoj Suda, Yusuke Fukazawa, Yasushi Metcalfe, Jessica Leys, Richard Peric, Ivan Shin, Taylor K.-W. Violette, Daniel NASA Postdoctoral Program Fellow United States NASA Goddard Space Flight Center GreenbeltMD United States University of California Santa Cruz Santa CruzCA United States Karlsruhe Institute of Technology Karlsruhe Germany Argonne National Laboratory LemontIL United States Physics Program Graduate School of Advanced Science and Engineering Hiroshima University Hiroshima739-8526 Japan

The precise reconstruction of Compton-scatter events is paramount for an imaging medium-energy gamma-ray telescope. The proposed AMEGO-X is enabled by a silicon tracker utilizing AstroPix chips - a pixelated silicon HVCMOS sensor novel for space use. To achieve science goals, each 500 × 500 µm2 pixel must be sensitive for energy deposits ranging from 25 - 700 keV with an energy resolution of 5 keV at 122 keV ( © 2024, CC BY.

关键词： Gamma rays

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Effects of carbon dioxide concentration and swine wastewater on the cultivation of Chlorella vulgaris FSP-E and bioethanol production from microalgae biomass

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Applied Energy 2024年 369卷

作者： Condor, Billriz E. de Luna, Mark Daniel G. Lacson, Carl Francis Z. Acebu, Paula Isabel G. Abarca, Ralf Ruffel M. Nagarajan, Dillirani Lee, Duu-Jong Chang, Jo-Shu Energy Engineering Program National Graduate School of Engineering University of the Philippines Diliman Quezon City Philippines Quezon City1101 Philippines Department of Chemical Engineering University of the Philippines Diliman Quezon City1101 Philippines Center of Excellence in Environmental Catalysis and Adsorption Thammasat University Pathum Thani12121 Thailand Department of Chemical Engineering and Technology Mindanao State University-Iligan Institute of Technology Iligan City9200 Philippines College of Hydrosphere Science Institute of Aquatic Science and Technology National Kaohsiung University of Science and Technology Kaohsiung City811532 Taiwan Department of Mechanical Engineering City University of Hong Kong Kowloon Tang Hong Kong Department of Chemical and Materials Engineering Tunghai University 407 Taiwan Research Center for Smart Sustainable Circular Economy Tunghai University Taichung407 Taiwan Department of Chemical Engineering National Cheng Kung University Tainan701 Taiwan Department of Chemical Engineering and Materials Science Yuan Ze University Chung-Li Taiwan

The study investigated the potential of wastewater-derived microalgae as a cost-effective feedstock for bioethanol production. The influence of CO2 loading, use of swine wastewater as a nutrient source, effect of micronutrients in the cultivation media, and scale-up of Chlorella vulgaris FSP-E was conducted. Results showed that 2% CO2, 25% swine wastewater, 500 mg/L sodium nitrate, 40 mg/L K2HPO4, 75 mg/L MgSO4, and 6 mg/L citric acid were optimal for maximal biomass production, nitrate removal, and carbohydrate accumulation in BG-11 medium. The maximum biomass and carbohydrate content obtained in this study were 35-fold and 60%, respectively. Scaling up to 5 L volume was challenging due to illumination, aeration, and mixing issues. The obtained carbohydrate-rich biomass was subjected to mild sulfuric acid hydrolysis and subsequently used for bioethanol fermentation. The hydrolysate was composed solely of glucose and galactose and was converted into bioethanol within 8 h by Saccharomyces cerevisiae with an ethanol yield of 0.22 ± 0.01 g ethanol per g biomass. Further exploration of effective lighting and mixing strategies are recommended to realize economically viable microalgal biofuels. © 2024 Elsevier Ltd

关键词： Biomass

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Development of Simultaneous Quantitative Analytical Method for Three Active Components of Agastache Rugosa in Human Plasma Using Ultra-High-Performance Liquid Chromatography–Tandem Mass Spectrometry

SSRN

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SSRN 2023年

作者： Rinik, Urmi Rahman Kim, Ji Eon Lee, Eunok Kwon, Oran Jung, Byung Hwa Center for Advanced Biomolecular Recognition Korea Institute of Science and Technology Seoul02792 Korea Republic of Division of Bio-medical Science and Technology KIST School University of Science and Technology Daejeon34113 Korea Republic of Department of Nutritional Science and Food Management Graduate Program in System Health Science and Engineering Ewha Womans University Korea Republic of

Abstract: Agastache rugosa contains phenolic compounds and flavonoids, and has been extensively used as a traditional herbal medicine. The major components in Agastache rugosa are rosmarinic acid, tilianin, and acacetin, for which several analytical techniques have been reported. However, these substances have yet to be simultaneously quantified in human plasma. In this study, we aimed to simultaneously determine the three active components of Agastacherugosa in human plasma by developing a reliable quantitative analytical method using ultra-high-performance liquid chromatography–tandem mass spectrometry (UHPLC-MS/MS). Chromatographic separation of the plasma samples was achieved using an ACQUITY UPLC® BEH C18 column with a gradient mobile phase of water and acetonitrile containing 0.1% formic acid. Mass spectrometric detection was performed using a triple quadrupole tandem mass spectrometer in negative electrospray ionization (ESI−) and multiple reaction monitoring (MRM) modes. The developed quantitative method was validated for the three active components. All three analytes exhibited a linear response over the ranges of 0.5–50 ng/mL for rosmarinic acid, 0.1–20 ng/mL for acacetin, and 0.5–20 ng/mL for tilianin with a weighting factor of 1/x (where x is the concentration). At three quality control (QC) concentration levels (low, medium, and high), including the lower limit of quantitation (LLOQ), acceptable accuracy (±15%) was achieved in the intra- and interday validations. The concentration of rosmarinic acid was highest in plasma. Tilianin and acacetin appeared and were eliminated earlier in the plasma than rosmarinic acid. This study provides a successfully validated method that can be used in further clinical applications of Agastache rugosa extracts. © 2023, The Authors. All rights reserved.

关键词： Mass spectrometers

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Atomic excitation delocalization at the clean to disordered interface in a chirally-coupled atomic array

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Physical Review Research 2024年第1期6卷 013159-013159页

作者： C.-C. Wu K.-T. Lin I. G. N. Y. Handayana C.-H. Chien S. Goswami G.-D. Lin Y.-C. Chen H. H. Jen Institute of Atomic and Molecular Sciences Academia Sinica Taipei 10617 Taiwan Department of Physics and Center for Quantum Science and Engineering National Taiwan University Taipei 10617 Taiwan Molecular Science and Technology Program Taiwan International Graduate Program Academia Sinica Taipei 115201 Taiwan Department of Physics National Central University Taoyuan City 320317 Taiwan Physics Division National Center for Theoretical Sciences Taipei 10617 Taiwan Trapped-Ion Quantum Computing Laboratory Hon Hai Research Institute Taipei 11492 Taiwan

In one-dimensional quantum emitter systems, the dynamics of atomic excitations are influenced by the collective coupling between emitters through photon-mediated dipole-dipole interactions. By introducing positional disorders in a portion of the atomic array, we investigate the delocalization phenomena at the interface between the disordered and clean zones. The excitation is initialized as symmetric Dicke states in the disordered zone, and several measures are used to quantify the excitation localization. We first use population imbalance and half-chain entropy to investigate the excitation dynamics under time evolutions, and further investigate the crossover of excitation localization to delocalization via the gap ratio from the eigenspectrum in the reciprocal coupling case. In particular, we study the participation ratio of the whole chain and the photon loss ratio between both ends of the atomic chain, which can be used to quantify the delocalization crossover in the nonreciprocal coupling cases. Furthermore, by increasing the overall size or the ratio of the disordered zone under a fixed number of the whole chain, we observe that excitation localization occurs at a smaller disorder strength in the former case, while in the latter, facilitation of the delocalization appears when a significant ratio of the clean zone to disordered zone is applied. Our results can reveal the competition between the clean zone and the disordered zone sizes on localization phenomenon, give insights to nonequilibrium dynamics in the emitter-waveguide interface, and provide potential applications in quantum information processing.

关键词： Localization Collective dynamics Disordered systems

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Participatory Design and Early Deployment of DarumaTO-3 Social Robot 14th

Participatory Design and Early Deployment of DarumaTO-3 So...

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14th International Conference on Social Robotics, ICSR 2022

作者： Shen, Zhihao Urano, Nanaka Chen, Chih-Pu Feng, Shi Mitchell, Scean Katagiri, Masao Du, Yegang Trevejo, Franco Pariasca Tomo, Tito P. Schmitz, Alexander Browne, Ryan Ogawa, Toshimi Taki, Yasuyuki Trovato, Gabriele Future Robotics Organization Waseda University Tokyo Japan School of International Liberal Studies Waseda University Tokyo Japan Graduate School of Science and Engineering Waseda University Tokyo Japan Pontifical Catholic University of Peru Lima Peru Smart Aging Research Center Tohoku University Miyagi Sendai Japan Innovative Global Program Shibaura Institute of Technology Tokyo Japan

ISBN: (纸本)9783031246692

With the problem of ageing population increasingly prominent, the burden of families, caregivers and medical workers to take care of older adults will be heavier. Social exclusion and cognitive dysfunctions make things worse, especially in times of a pandemic. One of the most effective approaches to solve these problems can be technology, which application is often limited by the acceptance of the end user. We introduce a social robot, DarumaTO-3, whose appearance is inspired by a traditional Buddhist and Shinto doll called Daruma, and perform a preliminary test in which we hear the response from older adults. This paper describes this new robot prototype, and reports the feedback received from the early deployment with 44 Japanese older adults. © 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.

关键词： Machine design

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Analysis of the musculoskeletal effects of lower limb slippage when indoor dogs walk on the wooden floor

Analysis of the musculoskeletal effects of lower limb slippa...

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IEEE International Symposium on Industrial Electronics (ISIE)

作者： Daisuke Chugo Miyabi Igarashi Satoshi Muramatsu Sho Yokota Jin-Hua She Hiroshi Hashimoto Uemura Takashi Hiroaki Kamishina Yoshiharu Hata Takayuki Yamada Takahiro Uchida Graduate School of Science and Technology Kwansei Gakuin University Sanda Hyogo Japan School of Science and Technology Kwansei Gakuin University Sanda Hyogo Japan School of Information Science and Technology Tokai University Hiratsuka Kanagawa Japan Faculty of Science and Engineering Toyo University Kawagoe Saitama Japan School of Engineering Tokyo University of Technology Hachioji Tokyo Japan Master Program of Innovation for Design and Engineering Advanced Institute of Industrial Technology Shinagawa Tokyo Japan KyotoAR Animal Advanced Medical Center Kuse Kyoto Japan Rinrei Co. Ltd. Chuo Tokyo Japan

ISBN: (数字)9798350394085

ISBN: (纸本)9798350394092

In recent years, dogs are commonly kept indoors. Dogs, as animals that inherently walk on grippy outdoor ground, sometimes slip when walking on indoor wooden flooring, which can lead to injuries and arthritis. We have therefore developed a method to increase the coefficient of friction by applying a special coating to the wooden flooring to make it less slippery when the dog walks on it. The objective of this paper is to investigate whether the friction coefficient of the flooring can prevent dogs’ lower limbs from slipping when they walk, and to analyze the effects of lower limb slippage on the musculoskeletal system of dogs when they walk on the flooring. In the measurement experiment, walking movements were performed with and without paint coating on the wooden flooring, the test dogs were applied to a 3D musculoskeletal system simulation software model, and the amount of muscular force exerted was calculated through a simulation experiment with measured data. In addition, the floor reaction forces of the lower limbs during walking were measured and compared, and the effects of the friction coefficient of the floor environment on walking behavior were discussed.

关键词： Legged locomotion Solid modeling Force measurement Three-dimensional displays Friction Force Dogs

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A robust bendable IrO_x thin film via mild alkaline solution process for neuron stimulating electrodes

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Surfaces and Interfaces 2024年 44卷

作者： Tso, Kuang-Chih Chan, Tzu-Ying Yu, Tsung-Chun Tao, Yu-Jen Chu, Chao-Yi Chen, San-Yuan Lee, Jyh-Fu Ohta, Jun Chen, Po-Chun Wu, Pu-Wei Graduate Program of Accelerator Light Source National Yang Ming Chiao Tung University Hsinchu 300 Taiwan Division of Materials Science Graduate School of Science and Technology Nara Institute of Science Technology Nara Ikoma Takayama 8916-5 Japan Department of Materials Science and Engineering National Yang Ming Chiao Tung University Hsinchu 300 Taiwan Institute of Materials Science and Engineering National Taipei University of Technology Taipei 106 Taiwan National Synchrotron Radiation Research Center Hsinchu 300 Taiwan

We demonstrate a unique chemical formula to deposit hydrous iridium oxide thin film on a platinum-coated polyimide substrate. In a mild alkaline solution, the iridium (III) precursor undergoes the ligand exchange and hydrolysis reaction to become the iridium (III) dimers that are physically adsorbed on the substrate for subsequent heterogeneous condensation and growth of amorphous hydrous iridium oxide thin film. Both UV–Vis and X-ray absorption spectroscopy (XAS) are employed to determine the reaction steps involved. The chemical nature and crystallinity of the hydrous iridium oxide thin film are investigated by XAS, X-ray photon spectroscopy, and X-ray diffraction. The hydrous iridium oxide thin film reveals an impressive normalized charge storage capacity (CSC) of 0.3 mC/cm²-nm and a low impedance (80.5 Ω) at 1k Hz. In addition, in bending test of 3,000 cycles, the hydrous iridium oxide thin film retains 91.2 % of its initial normalized CSC without any physical crack and delamination. The cell viability test suggests negligible bio-toxicity. Our results provide a solid evidence of fabricating a robust flexible electrode for neural interfaces for potential use in implantable electronic devices. © 2023 Elsevier B.V.

关键词： Bio-electrode Flexible substrate Implantable electronic devices Iridium dimers Iridium oxide Polyimide

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Plasmonic Nanolaser by Silver Nanowire Embedded in CsPbBr3 Quantum Dots

Plasmonic Nanolaser by Silver Nanowire Embedded in CsPbBr3 Q...

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JSAP-OSA Joint Symposia, JSAP 2021

作者： Xing, Di Lin, Cheng-Chieh Won, Phillip Xiang, Rong Chen, Tzu-Pei A. Kamal, A. Syazwan Lee, Yang-Chun Ho, Ya-Lun Maruyama, Shigeo Ko, Seung Hwan Chen, Chun-Wei Delaunay, Jean-Jacques School of Engineering The University of Tokyo Japan International Graduate Program of Molecular Science and Technology National Taiwan University Taiwan Department of Materials Science and Engineering National Taiwan University Taiwan Department of Mechanical Engineering Seoul National University Korea Republic of Center of Atomic Initiative for New Materials National Taiwan University Taiwan

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