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Meta-analysis of genome-wide association studies identifies multiple lung cancer susceptibility loci in never-smoking Asian women

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Human molecular genetics 2016年第3期25卷 620-9页

作者： Zhaoming Wang Wei Jie Seow Kouya Shiraishi Chao A Hsiung Keitaro Matsuo Jie Liu Kexin Chen Taiki Yamji Yang Yang I-Shou Chang Chen Wu Yun-Chul Hong Laurie Burdett Kathleen Wyatt Charles C Chung Shengchao A Li Meredith Yeager Amy Hutchinson Wei Hu Neil Caporaso Maria T Landi Nilanjan Chatterjee Minsun Song Joseph F Fraumeni Takashi Kohno Jun Yokota Hideo Kunitoh Kyota Ashikawa Yukihide Momozawa Yataro Daigo Tetsuya Mitsudomi Yasushi Yatabe Toyoaki Hida Zhibin Hu Juncheng Dai Hongxia Ma Guangfu Jin Bao Song Zhehai Wang Sensen Cheng Zhihua Yin Xuelian Li Yangwu Ren Peng Guan Jiang Chang Wen Tan Chien-Jen Chen Gee-Chen Chang Ying-Huang Tsai Wu-Chou Su Kuan-Yu Chen Ming-Shyan Huang Yuh-Min Chen Hong Zheng Haixin Li Ping Cui Huan Guo Ping Xu Li Liu Motoki Iwasaki Taichi Shimazu Shoichiro Tsugane Junjie Zhu Gening Jiang Ke Fei Jae Yong Park Yeul Hong Kim Jae Sook Sung Kyong Hwa Park Young Tae Kim Yoo Jin Jung Chang Hyun Kang In Kyu Park Hee Nam Kim Hyo-Sung Jeon Jin Eun Choi Yi Young Choi Jin Hee Kim In-Jae Oh Young-Chul Kim Sook Whan Sung Jun Suk Kim Ho-Il Yoon Sun-Seog Kweon Min-Ho Shin Adeline Seow Ying Chen Wei-Yen Lim Jianjun Liu Maria Pik Wong Victor Ho Fun Lee Bryan A Bassig Margaret Tucker Sonja I Berndt Wong-Ho Chow Bu-Tian Ji Junwen Wang Jun Xu Alan Dart Loon Sihoe James C M Ho John K C Chan Jiu-Cun Wang Daru Lu Xueying Zhao Zhenhong Zhao Junjie Wu Hongyan Chen Li Jin Fusheng Wei Guoping Wu She-Juan An Xu-Chao Zhang Jian Su Yi-Long Wu Yu-Tang Gao Yong-Bing Xiang Xingzhou He Jihua Li Wei Zheng Xiao-Ou Shu Qiuyin Cai Robert Klein William Pao Charles Lawrence H Dean Hosgood Chin-Fu Hsiao Li-Hsin Chien Ying-Hsiang Chen Chung-Hsing Chen Wen-Chang Wang Chih-Yi Chen Chih-Liang Wang Chong-Jen Yu Hui-Ling Chen Yu-Chun Su Fang-Yu Tsai Yi-Song Chen Yao-Jen Li Tsung-Ying Yang Chien-Chung Lin Pan-Chyr Yang Tangchun Wu Dongxin Lin Baosen Zhou Jinming Yu Hongbing Shen Michiaki Kubo Stephen J Chanock Nathaniel Rothman Qing Lan Cancer Genomics Research Laboratory Leidos Biomedical Research Inc. Gaithersburg MD USA Division of Cancer Epidemiology and Genetics National Cancer Institute National Institutes of Health Rockville MD USA wangzha@mail.nih.gov. Division of Cancer Epidemiology and Genetics National Cancer Institute National Institutes of Health Rockville MD USA. Division of Genome Biology National Cancer Center Hospital Tokyo Japan. Institute of Population Health Sciences. Division of Molecular Medicine Aichi Cancer Center Research Institute Nagoya Japan. Department of Oncology Shandong Cancer Hospital and Institute Shandong Academy of Medical Sciences Jinan China. Department of Epidemiology and Biostatistics National Clinical Research Center for Cancer Tianjin Medical University Cancer Institute and Hospital Tianjin China. Epidemiology and Prevention Group Research Center for Cancer Prevention and Screening National Cancer Center Tokyo Japan. Shanghai Pulmonary Hospital Shanghai China. National Institute of Cancer Research National Health Research Institutes Zhunan Taiwan. Department of Etiology & Carcinogenesis and State Key Laboratory of Molecular Oncology Cancer Institute and Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China. Department of Preventive Medicine. Cancer Genomics Research Laboratory Leidos Biomedical Research Inc. Gaithersburg MD USA Division of Cancer Epidemiology and Genetics National Cancer Institute National Institutes of Health Rockville MD USA. Cancer Genome Biology Group Institute of Predictive and Personalized Medicine of Cancer Barcelona Spain. Department of Medical Oncology Japanese Red Cross Medical Center Tokyo Japan. Laboratory for Genotyping Development RIKEN Center for Integrative Medical Sciences Yokohama Japan. Laboratory of Molecular Medicine Human Genome Center Institute of Medical Science University of Tokyo Tokyo Japan. Division of Thoracic Surgery Kinki University School of Medicine

Genome-wide association studies (GWAS) of lung cancer in Asian never-smoking women have previously identified six susceptibility loci associated with lung cancer risk. To further discover new susceptibility loci, we imputed data from four GWAS of Asian non-smoking female lung cancer (6877 cases and 6277 controls) using the 1000 Genomes Project (Phase 1 Release 3) data as the reference and genotyped additional samples (5878 cases and 7046 controls) for possible replication. In our meta-analysis, three new loci achieved genome-wide significance, marked by single nucleotide polymorphism (SNP) rs7741164 at 6p21.1 (per-allele odds ratio (OR) = 1.17; P = 5.8 × 10(-13)), rs72658409 at 9p21.3 (per-allele OR = 0.77; P = 1.41 × 10(-10)) and rs11610143 at 12q13.13 (per-allele OR = 0.89; P = 4.96 × 10(-9)). These findings identified new genetic susceptibility alleles for lung cancer in never-smoking women in Asia and merit follow-up to understand their biological underpinnings.

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Influence of structural parameters on electrical characteristics of schottky tunneling field-effect transistor and its scalability

Influence of structural parameters on electrical characteris...

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作者： Wu, Yan Dou, Chunmeng Wei, Feng Kakushima, Kuniyuki Ohmori, Kenji Ahmet, Parhat Watanabe, Takanobu Tsutsui, Kazuo Nishiyama, Akira Sugii, Nobuyuki Natori, Kenji Yamada, Keisaku Kataoka, Yoshinori Hattori, Takeo Iwai, Hiroshi Frontier Research Center Tokyo Institute of Technology Yokohama 226-8502 Japan Interdisciplinary Graduate School of Science and Engineering Tokyo Institute of Technology Yokohama 226-8502 Japan Honors Graduate Program for Nanotech/Sciences University of Tsukuba Tsukuba Ibaraki 305-8573 Japan Graduate School of Pure and Applied Sciences University of Tsukuba Tsukuba Ibaraki 305-8573 Japan Institute for Nanoscience and Nanotechnology Waseda University Shinjuku Tokyo 169-8555 Japan

The influence of structural parameters, including the Schottky barrier height for electron (Bn) and channel doping (Na), on the electrical characteristics of a scaled Schottky barrier tunneling FET (SBTFET) have been clarified by numerical device simulation. The thermionic emission current (ITH) as well as the tunneling current (ITN) have been considered as the main electron injections at the source edge. Simulation results have revealed that the main conduction is ITN in the region near and above the threshold voltage (Vth). As tunneling probability is determined by Bn and the width of the triangular potential barrier at the source edge, a lower Bn with higher Na results in a better subthreshold swing (SS) with high on-state drive current (ION) at a gate length (Lg) of 50 nm. With Lg scaling down to 10 nm, however, a lower Bn has shown an increased offstate leakage current (IOFF) due to the short-channel effect (SCE), while a larger Bn can suppress the IOFF at the cost of ION. Therefore, considering SS with ION and IOFF ratio, it can be concluded that an optimum Bn exists for short-channel devices. The SBTFET showed good subthreshold performance and higher ION=IOFF than the conventional silicon-on-insulator (SOI) MOSFET in 10nm region with the Schottky barrier height optimization. © 2013 The Japan Society of Applied Physics.

关键词： Threshold voltage

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Cascaded High-Gain Distributed Amplifier Configuration For Enhanced Gain-Bandwidth Product

Cascaded High-Gain Distributed Amplifier Configuration For E...

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International Conference on Electrical engineering/Electronics, Computer, Telecommunications and Information technology

作者： Panus Sinsoontornpong Ittipat Roopkom Apisak Worapishet The Electrical Engineering Graduate Program Faculty of Engineering Mahanakorn University of Technology Bangkok Thailand 10530 Mahanakorn Microelectronics Research Center (MMRC) Mahanakorn University of Technology Bangkok Thailand 10530

ISBN: (纸本)9781479905461

An improved distributed amplifier configuration based on a cascade of high-gain distributed amplifiers is introduced and investigated in this paper. The cascaded high-gain amplifier offers a multiplicative gain characteristic against the number of stages N and thus gain-bandwidth enhancement. The cascade connection also enables the use of the tapered drain line technique with no idle termination for further gain improvement. Verification is provided through simulation using a 0.18 μm RF CMOS process.

关键词： Distributed amplifiers wideband amplifiers CMOS amplifiers gain-bandwidth product cascaded amplifiers

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Human genome meeting 2016 : Houston, TX, USA. 28 February - 2 March 2016

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Human genomics 2016年第1期10 Suppl 1卷 12页

作者： A. K. Srivastava Y. Wang R. Huang C. Skinner T. Thompson L. Pollard T. Wood F. Luo R. Stevenson R. Polimanti J. Gelernter X. Lin I. Y. Lim Y. Wu A. L. Teh L. Chen I. M. Aris S. E. Soh M. T. Tint J. L. MacIsaac F. Yap K. Kwek S. M. Saw M. S. Kobor M. J. Meaney K. M. Godfrey Y. S. Chong J. D. Holbrook Y. S. Lee P. D. Gluckman N. Karnani A. Kapoor D. Lee A. Chakravarti C. Maercker F. Graf M. Boutros G. Stamoulis F. Santoni P. Makrythanasis A. Letourneau M. Guipponi N. Panousis M. Garieri P. Ribaux E. Falconnet C. Borel S. E. Antonarakis S. Kumar J. Curran J. Blangero S. Chatterjee J. Akiyama D. Auer C. Berrios L. Pennacchio T. R. Donti G. Cappuccio M. Miller P. Atwal A. Kennedy A. Cardon C. Bacino L. Emrick J. Hertecant F. Baumer B. Porter M. Bainbridge P. Bonnen B. Graham R. Sutton Q. Sun S. Elsea Z. Hu P. Wang Y. Zhu J. Zhao M. Xiong David A. Bennett A. Hidalgo-Miranda S. Romero-Cordoba S. Rodriguez-Cuevas R. Rebollar-Vega E. Tagliabue M. Iorio E. D’Ippolito S. Baroni B. Kaczkowski Y. Tanaka H. Kawaji A. Sandelin R. Andersson M. Itoh T. Lassmann Y. Hayashizaki P. Carninci A. R. R. Forrest C. A. Semple E. A. Rosenthal B. Shirts L. Amendola C. Gallego M. Horike-Pyne A. Burt P. Robertson P. Beyers C. Nefcy D. Veenstra F. Hisama R. Bennett M. Dorschner D. Nickerson J. Smith K. Patterson D. Crosslin R. Nassir N. Zubair T. Harrison U. Peters G. Jarvik F. Menghi K. Inaki X. Woo P. Kumar K. Grzeda A. Malhotra H. Kim D. Ucar P. Shreckengast K. Karuturi J. Keck J. Chuang E. T. Liu B. Ji A. Tyler G. Ananda G. Carter H. Nikbakht M. Montagne M. Zeinieh A. Harutyunyan M. Mcconechy N. Jabado P. Lavigne J. Majewski J. B. Goldstein M. Overman G. Varadhachary R. Shroff R. Wolff M. Javle A. Futreal D. Fogelman L. Bravo W. Fajardo H. Gomez C. Castaneda C. Rolfo J. A. Pinto K. C. Akdemir L. Chin S. Patterson C. Statz S. Mockus S. N. Nikolaev X. I. Bonilla L. Parmentier B. King F. Bezrukov G. Kaya V. Zoete V. Seplyarskiy H. Sharpe T. McKee K. Popadin N. Basset-Seguin R. Ben Chaabene M. Andrianova C. Verdan K. Grosdemange O. Sumara M. E JCSRI Greenwood Genetic Center Greenwood USA School of Computing Clemson University Clemson USA Biochemical Genetics Laboratory Greenwood Genetic Center Greenwood USA Department Psychiatry Yale Sch Med and VA CT Healthcare Center West Haven USA Department Genetics Yale Sch Med and VA CT Healthcare Center West Haven USA Department Neurobiology Yale Sch Med and VA CT Healthcare Center West Haven USA Singapore Institute for Clinical Sciences Singapore Singapore National University of Singapore Singapore Singapore University of British Columbia Vancouver Canada KK Women’s and Children’s Hospital Singapore Singapore University of Southampton and University Hospital Southampton NHS Foundation Trust Southampton UK University of Auckland Auckland New Zealand McKusick-Nathans Institute of Genetic Medicine Johns Hopkins University School of Medicine Baltimore USA Esslingen University of Applied Sciences Esslingen Germany German Cancer Research Center Heidelberg Germany Department of Genetic Medicine and Development University of Geneva Medical School Geneva Switzerland Geneva University Hospitals-HUG Service of Genetic Medicine Geneva Switzerland GE3 Institute of Genetics and Genomics of Geneva University of Geneva Medical School Geneva Switzerland South Texas Diabetes and Obesity Institute School of Medicine University of Texas Rio-Grande Valley Edinburg USA South Texas Diabetes and Obesity Institute School of Medicine University of Texas Rio-Grande Valley Brownsville USA Institute of Genetic Medicine Johns Hopkins University Baltimore USA Genomics Division Lawrence Berkeley National Laboratory Berkeley USA Molecular and Human Genetics Baylor College of Medicine Houston USA Department of Translational Medical Sciences Federico II University Naples Italy Metabolon Inc Durham USA Section of Pediatric Neurology and Neuroscience Baylor College of Medicine Houston USA Tawam Hospital Abu Dhabi United Arab Emirates Stanford Medical School Stanford USA Sch

O1 The metabolomics approach to autism: identification of biomarkers for early detection of autism spectrum disorder A. K. Srivastava, Y. Wang, R. Huang, C. Skinner, T. Thompson, L. Pollard, T. Wood, F. Luo, R. Stevenson O2 Phenome-wide association study for smoking- and drinking-associated genes in 26,394 American women with African, Asian, European, and Hispanic descents R. Polimanti, J. Gelernter O3 Effects of prenatal environment, genotype and DNA methylation on birth weight and subsequent postnatal outcomes: findings from GUSTO, an Asian birth cohort X. Lin, I. Y. Lim, Y. Wu, A. L. Teh, L. Chen, I. M. Aris, S. E. Soh, M. T. Tint, J. L. MacIsaac, F. Yap, K. Kwek, S. M. Saw, M. S. Kobor, M. J. Meaney, K. M. Godfrey, Y. S. Chong, J. D. Holbrook, Y. S. Lee, P. D. Gluckman, N. Karnani, GUSTO study group O4 High-throughput identification of specific qt interval modulating enhancers at the SCN5A locus A. Kapoor, D. Lee, A. Chakravarti O5 Identification of extracellular matrix components inducing cancer cell migration in the supernatant of cultivated mesenchymal stem cells C. Maercker, F. Graf, M. Boutros O6 Single cell allele specific expression (ASE) IN T21 and common trisomies: a novel approach to understand DOWN syndrome and other aneuploidies G. Stamoulis, F. Santoni, P. Makrythanasis, A. Letourneau, M. Guipponi, N. Panousis, M. Garieri, P. Ribaux, E. Falconnet, C. Borel, S. E. Antonarakis O7 Role of microRNA in LCL to IPSC reprogramming S. Kumar, J. Curran, J. Blangero O8 Multiple enhancer variants disrupt gene regulatory network in Hirschsprung disease S. Chatterjee, A. Kapoor, J. Akiyama, D. Auer, C. Berrios, L. Pennacchio, A. Chakravarti O9 Metabolomic profiling for the diagnosis of neurometabolic disorders T. R. Donti, G. Cappuccio, M. Miller, P. Atwal, A. Kennedy, A. Cardon, C. Bacino, L. Emrick, J. Hertecant, F. Baumer, B. Porter, M. Bainbridge, P. Bonnen, B. Graham, R. Sutton, Q. Sun, S. Elsea O10 A novel causal methylation network approach to Alzheimer’s

关键词： Pulmonary Arterial Hypertension Oral Squamous Cell Carcinoma Deep Neural Network Autosomal Recessive Polycystic Kidney Disease Whole Genome Bisulfite Sequencing

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Band classification based on chromosome shapes

Band classification based on chromosome shapes

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Biomedical engineering International Conference (BMEiCON)

作者： Ravi Uttamatanin Peerapol Yuvapoositanon Apichart Intarapanich Saowaluck Kaewkamnerd Sissades Tongsima The Electrical Engineering Graduate Program Mahanakorn University of Technology Bangkok Thailand National Electronics and Computer Technology Center Pathum thani Thailand Electronic Engineering Department Mahanakorn University of Technology Bangkok Thailand National Center for Genetic Engineering and Biotechnology Pathum thani Thailand

For an automatic chromosome classification, band resolution information is required in order to perform diagnosis on numerical and structural abnormalities. Metaphases with low band resolution are normal used for numerical abnormality analysis while metaphases with high band resolution are used for structural abnormality analysis. In our work, we classify metaphases into low and high band resolution groups using chromosome shape. This band classification task can automatically perform without human intervention leading to faster the diagnosis process. The results showed that chromosome shape information is able to classify metaphases into low and high band resolution groups with the accuracy of 73.08% and 95.24%, respectively.

关键词： Biological cells Image resolution Probability density function Shape Accuracy Image segmentation Microscopy

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Abstracts from the 3rd International Genomic Medicine Conference (3rd IGMC 2015) : Jeddah, Kingdom of Saudi Arabia. 30 November - 3 December 2015

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BMC genomics 2016年第6期17 Suppl 6卷 487页

作者： Jerry W. Shay Noriko Homma Ruyun Zhou Muhammad Imran Naseer Adeel G. Chaudhary Mohammed Al-Qahtani Nobutaka Hirokawa Maryam Goudarzi Albert J. Fornace Saleh Baeesa Deema Hussain Mohammed Bangash Fahad Alghamdi Hans-Juergen Schulten Angel Carracedo Ishaq Khan Hanadi Qashqari Nawal Madkhali Mohamad Saka Kulvinder S. Saini Awatif Jamal Jaudah Al-Maghrabi Adel Abuzenadah Adeel Chaudhary Mohammed Al Qahtani Ghazi Damanhouri Heba Alkhatabi Anne Goodeve Laura Crookes Nikolas Niksic Nicholas Beauchamp Adel M. Abuzenadah Jim Vaught Bruce Budowle Mourad Assidi Abdelbaset Buhmeida Leena Merdad Sudhir Kumar Sayaka Miura Karen Gomez Mahmood Rasool Ahmed Rebai Sajjad Karim Hend F. Nour Eldin Heba Abusamra Elham M. Alhathli Nada Salem Mohammed H. Al-Qahtani Hossam Faheem Ashok Agarwa Eberhard Nieschlag Joachim Wistuba Oliver S. Damm Mohd A. Beg Taha A. Abdel-Meguid Hisham A. Mosli Osama S. Bajouh Serdar Coskun Muhammad Abu-Elmagd Ashraf Dallol Sahar Hakamy Wejdan Al-Qahtani Asia Al-Harbi Shireen Hussain Burak Ozkosem Rick DuBois Safia S. Messaoudi Maryam T. Dandana Touhami Mahjoub Wassim Y. Almawi S. Abdalla M. Nabil Al-Aama Asmaa Elzawahry Tsuyoshi Takahashi Sachiyo Mimaki Eisaku Furukawa Rie Nakatsuka Isao Kurosaka Takahiko Nishigaki Hiromi Nakamura Satoshi Serada Tetsuji Naka Seiichi Hirota Tatsuhiro Shibata Katsuya Tsuchihara Toshirou Nishida Mamoru Kato Sajid Mehmood Naeem Mahmood Ashraf Awais Asif Muhammad Bilal Malik Siddique Mehmood Aadil Hussain Qazi Mohammad Sajid Jamal Mughees Uddin Siddiqui Mohammad A. Alzohairy Mohammad A. Al Karaawi Taoufik Nedjadi Heba Al-Khattabi Adel Al-Ammari Ahmed Al-Sayyad Hédia Zitouni Nozha Raguema Marwa Ben Ali Wided Malah Raja Lfalah Wassim Almawi Mohammed Elanbari Andrey Ptitsyn Sana Mahjoub Rabeb El Ghali Bechir Achour Nidhal Ben Amor Brahim N’siri Hamid Morjani Esam Azhar Vera Chayeb Maryam Dendena Hedia Zitouni Khedija Zouari-Limayem Bassem Refaat Ahmed M. Ashshi Sarah A. Batwa Hazem Ramadan Amal Awad Ahmed Ateya Adel Galal Ahmed El-Shemi Ahmad Ashshi Mohammed Basalamah Youjin Na Cha University of Texas Southwestern Medical Center Dallas USA Department of Cell Biology and Anatomy Graduate School of Medicine the University of Tokyo Tokyo Japan Center of Excellence in Genomic Medicine Research King Abdulaziz University Jeddah Saudi Arabia Department of Biochemistry and Molecular & Cellular Biology Lombardi Comprehensive Cancer Center Georgetown University Washington USA Department of Oncology Lombardi Comprehensive Cancer Center Georgetown University Washington USA Department of Radiation Medicine Lombardi Comprehensive Cancer Center Georgetown University Washington USA Center of Excellence in Genomic Medicine Research (CEGMR) King Abdulaziz University Jeddah Kingdom of Saudi Arabia King Fahd Medical Research Centre King Abdulaziz University Jeddah Saudi Arabia Centre of Excellence in Genomic Medicine Research King Abdulaziz University Jeddah Saudi Arabia Sheffield Diagnostic Genetic Service Sheffield Children’s NHS Foundation Trust Western Bank Sheffield UK Center of Innovations in Personalized Medicine King Abdulaziz University Jeddah Saudi Arabia President ISBER Editor-in-Chief Biopreservation & Biobanking ᅟ USA Institute of Applied Genetics Department of Molecular and Medical Genetics University of North Texas Health Science Center Fort Worth USA Department of Dental Public Health Faculty of Dentistry King Abdulaziz University Jeddah Saudi Arabia Institute for Genomics and Evolutionary Medicine Temple University Philadelphia USA Center of Excellence in Genomic Medicine King Abdulaziz University Jeddah Kingdom of Saudi Arabia Laboratory of Molecular and Cellular Screening Processes (Bioinformatics Group) Centre of Biotechnology of Sfax Sfax Tunisia Fujitsu Technology Solutions International ᅟ ᅟ Case Western Reserve University School of Medicine and Lerner College of Medicine Cleveland Clinic Foundation Cleveland USA American Center for Reproductive Medicine Andrology Center Cleveland USA Center for Reproductive Medicine and

O1 Regulation of genes by telomere length over long distances Jerry W. Shay O2 The microtubule destabilizer KIF2A regulates the postnatal establishment of neuronal circuits in addition to prenatal cell survival, cell migration, and axon elongation, and its loss leading to malformation of cortical development and severe epilepsy Noriko Homma, Ruyun Zhou, Muhammad Imran Naseer, Adeel G. Chaudhary, Mohammed Al-Qahtani, Nobutaka Hirokawa O3 Integration of metagenomics and metabolomics in gut microbiome research Maryam Goudarzi, Albert J. Fornace Jr. O4 A unique integrated system to discern pathogenesis of central nervous system tumors Saleh Baeesa, Deema Hussain, Mohammed Bangash, Fahad Alghamdi, Hans-Juergen Schulten, Angel Carracedo, Ishaq Khan, Hanadi Qashqari, Nawal Madkhali, Mohamad Saka, Kulvinder S. Saini, Awatif Jamal, Jaudah Al-Maghrabi, Adel Abuzenadah, Adeel Chaudhary, Mohammed Al Qahtani, Ghazi Damanhouri O5 RPL27A is a target of miR-595 and deficiency contributes to ribosomal dysgenesis Heba Alkhatabi O6 Next generation DNA sequencing panels for haemostatic and platelet disorders and for Fanconi anaemia in routine diagnostic service Anne Goodeve, Laura Crookes, Nikolas Niksic, Nicholas Beauchamp O7 Targeted sequencing panels and their utilization in personalized medicine Adel M. Abuzenadah O8 International biobanking in the era of precision medicine Jim Vaught O9 Biobank and biodata for clinical and forensic applications Bruce Budowle, Mourad Assidi, Abdelbaset Buhmeida O10 Tissue microarray technique: a powerful adjunct tool for molecular profiling of solid tumors Jaudah Al-Maghrabi O11 The CEGMR biobanking unit: achievements, challenges and future plans Abdelbaset Buhmeida, Mourad Assidi, Leena Merdad O12 Phylomedicine of tumors Sudhir Kumar, Sayaka Miura, Karen Gomez O13 Clinical implementation of pharmacogenomics for colorectal cancer treatment Angel Carracedo, Mahmood Rasool O14 From association to causality: translation of GWAS findings for genomic me

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Solution-processed zinc oxide nanoparticles as interlayer materials for inverted organic solar cells

Solution-processed zinc oxide nanoparticles as interlayer ma...

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作者： Ibrahem, Mohammed Aziz Wei, Hung-Yu Tsai, Meng-Hung Ho, Kuo-Chuan Shyue, Jing-Jong Chu, Chih Wie Department of Physics National Taiwan University Taipei 106 Taiwan Research Center of Applied Science Academia Sinica Taipei 115 Taiwan Nanoscience and Technology Program Taiwan International Graduate Program Academia Sinica Taipei 115 Taiwan Institute of Polymer Science and Engineering National Taiwan University Taipei 10617 Taiwan Department of Material Science and Engineering National Taiwan University Taipei 106 Taiwan Department of Photonics National Chiao Tung University Hsinchu 300 Taiwan

This paper describes inverted bulk heterojunction organic solar cells featuring solution-processed zinc oxide nanoparticles (ZnO NPs) as an electron extraction layer, prepared at relatively low annealing temperatures (≤150°C). A solution of ZnO NPs (average size: 25 nm) was prepared using a wet grinding method. When the ZnO interlayer was present in the solar cell, the vertical phase separation of the active layers prepared with and without solvent annealing exhibited similar gradient concentrations and, therefore, similar photocurrent generation, both of which were superior to those of conventional devices incorporating a poly(3,4-ethylenedioxythiophene): poly(styrene sulfonic acid) (PEDOT:PSS) hole extraction layer. We attribute this vertical phase separation to the similar surface energies of the fullerene derivative and the ZnO interlayer. Under simulated air mass (AM) 1.5 G illumination at 100 mW cm-2, the power conversion efficiency of the optimized device was approximately 4%. © 2012 Elsevier B.V.

关键词： Zinc oxide

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Determination of developing trend for a novelty microbial electrolysis cell by a modified inventive problem solving approach

Determination of developing trend for a novelty microbial el...

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作者： Li, Ya-Chieh Chu, Chen-Yeon Chien, Wei-Che Chang, Pao-Long Hsu, Chiung-Wen Wu, Shu-Yii Dept. of Chemical Engineering Feng Chia University Taichung 40724 Taiwan Green Energy Development Center Feng Chia University Taichung 40724 Taiwan Master Program of Green Energy Science and Technology Feng Chia University Taichung 40724 Taiwan Department of Business Administration Feng Chia University Taichung 40724 Taiwan Graduate Institute of Management of Technology Feng Chia University Taichung 40724 Taiwan

Nowadays, the design of waste treatment needs to be environmentally- friendly. Due to the fact that the concern of global warming is getting critical, the reuse of waste treatment can be beneficial in reducing carbon dioxide emission. Microbial electrolysis cell (MEC) is a device that can reduce the organic materials and produce the green energy, biohydrogen. Therefore, MEC provides an alternative path for waste degradation. In this study, MEC was analyzed with TRIZ that aims to eliminate contradiction matrix from the analysis in order to improve the MEC efficiency. The study approach is based on the following steps: classifying patents and paper, determining engineering parameters;solving the contradictory problems with 40 innovative principles, and finding the solutions. The results were verified by the currently researches. © 2013, Hydrogen Energy Publications, LLC. Published by Elsevier Ltd. All rights reserved.

关键词： Global warming

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P113. Learning volitional control of functional connectivity: Effects on behaviour

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Clinical Neurophysiology 2015年第8期126卷 e104-e104页

作者： D. Singh Kajal J. Mellinger S. Ruiz M. Sacchet E. Fetz N. Birbaumer R. Sitaram C. Braun Universität Tübingen MEG-Zentrum Tübingen Germany Universität Tübingen Graduate Training Center Tübingen Germany Universität Tübingen Institute of Medical Psychology Tübingen Germany Pontificia Universidad Catolica de Chile Departamento de Psiquiatría Santiago Chile Stanford University School of Medicine Neuroscience Program Stanford United States Stanford University Department of Psychology Stanford United States University of Washington Department of Physiology and Biophysics Seattle United States San Camillo Hospital Scientific Institute for Research Hospitalization and Health Care Venice Italy University of Florida Department of Biomedical Engineering Gainsville United States Sri Chitra Tirunal Institute for Medical Sciences and Technology Trivandrum India Università degli Studi di Trento CIMeC Centro interdipartimentale Mente e Cervello Trento Italy

Cerebral information processing involves the activation of brain regions and the exchange of information between them. As metric for intra-cortical communication, coherence, a frequency specific measure quantifying the correlation of the amplitudes across trials of two phase-locked signals, has been suggested. A value of 0 indicates that both signals are unrelated, a value of 1 that both signals are fully synchronized. It is evidenced by the plethora of findings that the functional connectivity between brain regions is modulated by brain states, mental processing and the planning and execution of actions. Thus, it might be hypothesized that volitionally modulating the functional connectivity between two interacting brain regions should have an impact either on behavior or cognition. The purpose of the study was to test whether subjects can learn to volitionally modulate brain functional connectivity between left and right motor cortices employing a neurofeedback training and whether the neurofeedback training induces specific effects on motor function. Thirty right-handed subjects participated in the study. The subject group was partitioned into two sub-groups, namely contingent feedback group and sham feedback group, consisting of fifteen subjects. During the neurofeedback training the magnetic brain activity originating from left and right primary motor cortices was recorded using magnetoencephalography (MEG) and a feedback signal representing the coherence between the primary motor cortices of both hemispheres was presented to the subjects on a screen. Subjects receiving contingent feedback were trained to increase coherence while the discriminative stimulus S D+ was presented and to decrease coherence while the S D− was presented. A pretest and posttest examination served to examine whether acquired control on functional connectivity evidences any behavioral effects. During pre- and posttest subjects had to perform a complex bimanual finger tapping task while th

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A Depressurization Assistance System with a Suitable Posture for a Seated Patient on a Wheelchair

A Depressurization Assistance System with a Suitable Posture...

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IEEE International Conference on Rehabilitation Robotics

作者： Kenji Shiotani Daisuke Chugo Sho Yokota Yuki Sakaida Hiroshi Hashimoto Graduate School of Science and Technology Kwansei Gakuin University Hyogo Japan Faculty of Science and Engineering Setsunan University Osaka Japan RIKEN-TRI Collaboration Center for Human-Interactive Robot Research (RTC) Master Program of Innovation for Design and Engineering Advanced Institute of Industrial Technology Tokyo Japan

ISBN: (纸本)9781467360210

For reducing a risk of pressure sore caused by long period sitting on a wheelchair, a patient is required to depressurize buttocks by changing the posture suitably. Thus, we have been developed an automatic depressurization motion assistance system for a seated patient on a wheelchair. In our previous work, we developed a sitting surface coordination system which can lift or incline and assists a depressurization motion of a patient. However, in some cases, it is difficult to change his posture suitably for patients who do not have enough physical strength in their upper body using our proposed device. Therefore, in this paper, we propose a novel posture coordination assistance system for a wheelchair user. Our system consists of the adjustable sitting surface and novel proposed adjustable backrest. These two devices coordinate the sitting posture of the patient automatically. Our key ideas are two topics. One topic is mechanical design of the adjustable backrest for practical use. We realize small mechanism which enables easy implementation to a general wheelchair without special reconstruction. The other topic is a natural posture coordination scheme using the sitting surface and the backrest. We analyze buttocks depressurization operation by a nursing specialist and drive our proposed devices for realizing it. The performance of our system is verified by experiments using our prototype.

关键词： Depressurization motion assistance Pressure sore Adjustable backrest Wheelchair

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