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Author Correction: The power of genetic diversity in genome-wide association studies of lipids

Nature 2023年第7965期618卷 E19-E20页

作者： Sarah E Graham Shoa L Clarke Kuan-Han H Wu Stavroula Kanoni Greg J M Zajac Shweta Ramdas Ida Surakka Ioanna Ntalla Sailaja Vedantam Thomas W Winkler Adam E Locke Eirini Marouli Mi Yeong Hwang Sohee Han Akira Narita Ananyo Choudhury Amy R Bentley Kenneth Ekoru Anurag Verma Bhavi Trivedi Hilary C Martin Karen A Hunt Qin Hui Derek Klarin Xiang Zhu Gudmar Thorleifsson Anna Helgadottir Daniel F Gudbjartsson Hilma Holm Isleifur Olafsson Masato Akiyama Saori Sakaue Chikashi Terao Masahiro Kanai Wei Zhou Ben M Brumpton Humaira Rasheed Sanni E Ruotsalainen Aki S Havulinna Yogasudha Veturi QiPing Feng Elisabeth A Rosenthal Todd Lingren Jennifer Allen Pacheco Sarah A Pendergrass Jeffrey Haessler Franco Giulianini Yuki Bradford Jason E Miller Archie Campbell Kuang Lin Iona Y Millwood George Hindy Asif Rasheed Jessica D Faul Wei Zhao David R Weir Constance Turman Hongyan Huang Mariaelisa Graff Anubha Mahajan Michael R Brown Weihua Zhang Ketian Yu Ellen M Schmidt Anita Pandit Stefan Gustafsson Xianyong Yin Jian'an Luan Jing-Hua Zhao Fumihiko Matsuda Hye-Mi Jang Kyungheon Yoon Carolina Medina-Gomez Achilleas Pitsillides Jouke Jan Hottenga Gonneke Willemsen Andrew R Wood Yingji Ji Zishan Gao Simon Haworth Ruth E Mitchell Jin Fang Chai Mette Aadahl Jie Yao Ani Manichaikul Helen R Warren Julia Ramirez Jette Bork-Jensen Line L Kårhus Anuj Goel Maria Sabater-Lleal Raymond Noordam Carlo Sidore Edoardo Fiorillo Aaron F McDaid Pedro Marques-Vidal Matthias Wielscher Stella Trompet Naveed Sattar Line T Møllehave Betina H Thuesen Matthias Munz Lingyao Zeng Jianfeng Huang Bin Yang Alaitz Poveda Azra Kurbasic Claudia Lamina Lukas Forer Markus Scholz Tessel E Galesloot Jonathan P Bradfield E Warwick Daw Joseph M Zmuda Jonathan S Mitchell Christian Fuchsberger Henry Christensen Jennifer A Brody Mary F Feitosa Mary K Wojczynski Michael Preuss Massimo Mangino Paraskevi Christofidou Niek Verweij Jan W Benjamins Jorgen Engmann Rachel L Kember Roderick C Slieker Ken Sin Lo Nuno R Zilhao Phuong Le Marcus E Kleber Graciela E Delgado Shaofeng Huo Dai Department of Internal Medicine Division of Cardiology University of Michigan Ann Arbor MI USA. VA Palo Alto Health Care System Palo Alto CA USA. Department of Medicine Division of Cardiovascular Medicine Stanford University School of Medicine Stanford CA USA. Department of Computational Medicine and Bioinformatics University of Michigan Ann Arbor MI USA. William Harvey Research Institute Barts and the London School of Medicine and Dentistry Queen Mary University of London London UK. Department of Biostatistics and Center for Statistics Genetics University of Michigan Ann Arbor MI USA. Department of Genetics Perelman School of Medicine University of Pennsylvania Philadelphia PA USA. Clinical Pharmacology William Harvey Research Institute Barts and The London School of Medicine and Dentistry Queen Mary University of London London UK. Endocrinology Boston Children's Hospital Boston MA USA. Medical and Population Genetics Broad Institute Cambridge MA USA. Department of Genetic Epidemiology University of Regensburg Regensburg Germany. McDonnell Genome Institute and Department of Medicine Washington University St Louis MO USA. Department of Precision Medicine Division of Genome Science National Institute of Health Cheongju-si South Korea. Tohoku Medical Megabank Organization Tohoku University Sendai Japan. Sydney Brenner Institute for Molecular Bioscience Faculty of Health Sciences University of the Witwatersrand Johannesburg South Africa. Center for Research on Genomics and Global Health National Human Genome Research Institute National Institutes of Health Bethesda MD USA. Blizard Institute Barts and the London School of Medicine and Dentistry Queen Mary University of London London UK. Wellcome Sanger Institute Hinxton UK. Department of Epidemiology Emory University Rollins School of Public Health Atlanta GA USA. Atlanta VA Health Care System Decatur GA USA. Malcolm Randall VA Medical Center Gainesville FL USA. Division of Vascular Sur

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Proton acceleration in thermonuclear nova explosions revealed by gamma rays (Apr, 10.1038/s41550-022-01640-z, 2022)

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NATURE ASTRONOMY 2022年第6期6卷 760-760页

作者： Acciari, V. A. Ansoldi, S. Antonelli, L. A. Engels, A. Arbet Artero, M. Asano, K. Baack, D. Babic, A. Baquero, A. de Almeida, U. Barres Barrio, J. A. Batkovic, I. Gonzalez, J. Becerra Bednarek, W. Bellizzi, L. Bernardini, E. Bernardos, M. Berti, A. Besenrieder, J. Bhattacharyya, W. Bigongiari, C. Biland, A. Blanch, O. Bokenkamp, H. Bonnoli, G. Bosnjak, Z. Busetto, G. Carosi, R. Ceribella, G. Cerruti, M. Chai, Y. Chilingarian, A. Cikota, S. Colak, S. M. Colombo, E. Contreras, J. L. Cortina, J. Covino, S. D'Amico, G. D'Elia, V. Da Vela, P. Dazzi, F. De Angelis, A. De Lotto, B. Del Popolo, A. Delfino, M. Delgado, J. Mendez, C. Delgado Depaoli, D. Di Pierro, F. Di Venere, L. Espineira, E. Do Souto Prester, D. Dominis Donini, A. Dorner, D. Doro, M. Elsaesser, D. Ramazani, V. Fallah Alonso, L. Farina Fattorini, A. Fonseca, M. V. Font, L. Fruck, C. Fukami, S. Fukazawa, Y. Lopez, R. J. Garcia Garczarczyk, M. Gasparyan, S. Gaug, M. Giglietto, N. Giordano, F. Gliwny, P. Godinovic, N. Green, J. G. Green, D. Hadasch, D. Hahn, A. Hassan, T. Heckmann, L. Herrera, J. Hoang, J. Hrupec, D. Hutten, M. Inada, T. Ishio, K. Iwamura, Y. Martinez, I. Jimenez Jormanainen, J. Jouvin, L. Kerszberg, D. Kobayashi, Y. Kubo, H. Kushida, J. Lamastra, A. Lelas, D. Leone, F. Lindfors, E. Linhoff, L. Lombardi, S. Longo, F. Lopez-Coto, R. Lopez-Moya, M. Lopez-Oramas, A. Loporchio, S. de Oliveira Fraga, B. Machado Maggio, C. Majumdar, P. Makariev, M. Mallamaci, M. Maneva, G. Manganaro, M. Mannheim, K. Maraschi, L. Mariotti, M. Martinez, M. Aguilar, A. Mas Mazin, D. Menchiari, S. Mender, S. Micanovic, S. Miceli, D. Miener, T. Miranda, J. M. Mirzoyan, R. Molina, E. Moralejo, A. Morcuende, D. Moreno, V. Moretti, E. Nakamori, T. Nava, L. Neustroev, V. Rosillo, M. Nievas Nigro, C. Nilsson, K. Nishijima, K. Noda, K. Nozaki, S. Ohtani, Y. Oka, T. Otero-Santos, J. Paiano, S. Palatiello, M. Paneque, D. Paoletti, R. Paredes, J. M. Pavletic, L. Penil, P. Persic, M. Pihet, M. Moroni, P. G. Prada Prandini, E. Priyadarshi, C. Puljak, I. Rhode, W. Ribo, M. Rico, Universidad de La Laguna Instituto de Astrofísica de Canarias and Departamento de Astrofísica La Laguna Spain (GRID:grid.10041.34) (ISNI:***) Università di Udine and INFN Trieste Udine Italy (GRID:grid.5390.f) (ISNI:0000 0001 2113 062X) International Center for Relativistic Astrophysics (ICRA) Rome Italy (GRID:grid.5390.f) National Institute for Astrophysics (INAF) Rome Italy (GRID:grid.4293.c) (ISNI:0000 0004 1792 8585) Max-Planck-Institut für Physik Munich Germany (GRID:grid.435824.c) (ISNI:0000 0001 2375 0603) The Barcelona Institute of Science and Technology (BIST) Institut de Física d’Altes Energies (IFAE) Barcelona Spain (GRID:grid.473715.3) (ISNI:0000 0004 6475 7299) Japanese MAGIC Group: Institute for Cosmic Ray Research (ICRR) The University of Tokyo Kashiwa Japan (GRID:grid.26999.3d) (ISNI:0000 0001 2151 536X) Technische Universität Dortmund Dortmund Germany (GRID:grid.5675.1) (ISNI:0000 0001 0416 9637) Croatian MAGIC Group: University of Zagreb Faculty of Electrical Engineering and Computing (FER) Zagreb Croatia (GRID:grid.4808.4) (ISNI:0000 0001 0657 4636) Universidad Complutense de Madrid IPARCOS Institute and EMFTEL Department Madrid Spain (GRID:grid.4795.f) (ISNI:0000 0001 2157 7667) Centro Brasileiro de Pesquisas Físicas (CBPF) Rio de Janeiro Brazil (GRID:grid.418228.5) (ISNI:0000 0004 0643 8134) Università di Padova and INFN Padua Italy (GRID:grid.5608.b) (ISNI:0000 0004 1757 3470) University of Lodz Department of Astrophysics Faculty of Physics and Applied Informatics Lodz Poland (GRID:grid.10789.37) (ISNI:0000 0000 9730 2769) Università di Siena and INFN Pisa Siena Italy (GRID:grid.9024.f) (ISNI:0000 0004 1757 4641) Deutsches Elektronen-Synchrotron (DESY) Zeuthen Germany (GRID:grid.7683.a) (ISNI:0000 0004 0492 0453) ETH Zürich Zurich Switzerland (GRID:grid.5801.c) (ISNI:0000 0001 2156 2780) Instituto de Astrofísica de Andalucía-CSIC Granada Spain (GRID:grid.450285.e) (ISNI:0000 0004 1793 7043) Università di Pisa and INFN Pisa Pisa Italy (GRID:grid.5395.

Classical novae are cataclysmic binary star systems in which the matter of a companion star is accreted on a white dwarf1,2. Accumulation of hydrogen in a layer eventually causes a thermonuclear explosion on the surface of the white dwarf3, brightening the white dwarf to ~105 solar luminosities and triggering ejection of the accumulated matter. Novae provide the extreme conditions required to accelerate particles, electrons or protons, to high energies. Here we present the detection of gamma rays by the MAGIC telescopes from the 2021 outburst of RS Ophiuchi, a recurrent nova with a red giant companion, which allowed us to accurately characterize the emission from a nova in the 60 GeV to 250 GeV energy range. The theoretical interpretation of the combined Fermi LAT and MAGIC data suggests that protons are accelerated to hundreds of gigaelectronvolts in the nova shock. Such protons should create bubbles of enhanced cosmic ray density, of the order of 10 pc, from the recurrent *** of the 2021 outburst of the nova RS Oph in very-high-energy gamma rays by the MAGIC telescopes is reported. Investigation of the gamma-ray emission provides evidence for acceleration of protons within the nova shock, which then propagate outwards to create bubbles of enhanced cosmic ray density.

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Galactic transient sources with the Cherenkov Telescope Array Observatory

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Monthly Notices of the Royal Astronomical Society 2025年第1期540卷 205–238页

作者： Abe, K Abe, S Abhir, J Abhishek, A Acero, F Acharyya, A Adam, R Aguasca-Cabot, A Agudo, I Aguirre-Santaella, A Alfaro, J Alfaro, R Alvarez-Crespo, N Alves Batista, R Amans, J-P Amato, E Ambrosi, G Ambrosino, F Angüner, E O Antonelli, L A Aramo, C Arcaro, C Arnesen, T T H Asano, K Ascasibar, Y Aschersleben, J Ashkar, H Augusto Stuani, L Baack, D Backes, M Balazs, C Balbo, M Baquero Larriva, A Barbosa Martins, V Barres de Almeida, U Barrio, J A Barrios-Jiménez, L Batković, I Batzofin, R Baxter, J Becerra González, J Becker Tjus, J Belmont, R Benbow, W Bernete, J Bernlöhr, K Berti, A Bertucci, B Beshley, V Bhattacharjee, P Bhattacharyya, S Bigongiari, C Bissaldi, E Blanch, O Blazek, J Bocchino, F Boisson, C Bolmont, J Bonnoli, G Bonollo, A Bordas, P Bosnjak, Z Bottacini, E Böttcher, M Bradascio, F Bronzini, E Brown, A M Brunelli, G Bulgarelli, A Burelli, I Burger-Scheidlin, C Burmistrov, L Burton, M Buscemi, M Cailleux, J Campoy-Ordaz, A Cantlay, B K Capasso, G Caproni, A Capuzzo-Dolcetta, R Caraveo, P Caroff, S Carosi, A Carosi, R Carquin, E Carrasco, M-S Cascone, E Cassol, F Castaldini, L Castrejon, N Castro-Tirado, A J Cerasole, D Ceribella, G Cerruti, M Chadwick, P M Chaty, S Chen, A W Chernyakova, M Chiavassa, A Chudoba, J Chytka, L Cicciari, G M Cifuentes, A Coimbra Araujo, C H Colapietro, M Conforti, V Contreras, J L Cortina, J Costa, A Costantini, H Cotter, G Cristofari, P Cuevas, O Curtis-Ginsberg, Z D’Aì, A D’Amico, G D’Ammando, F Dai, S Dazzi, F de Bony de Lavergne, M De Caprio, V De Cesare, G De Frondat Laadim, F de Gouveia Dal Pino, E M De Lotto, B De Lucia, M de Martino, D de Menezes, R de Naurois, M de Ona Wilhelmi, E de Souza, V del Peral, L del Valle, M V Delgado, C Dell’aiera, M Della Valle, M della Volpe, D Depaoli, D Devin, J Di Girolamo, T Di Piano, A Di Pierro, F Di Tria, R Di Venere, L Diebold, S Dignam, C Dima, R Dinesh, A Djuvsland, J Dominik, R M Dominis Prester, D Donini, A Dorner, D Dörner, J Doro, M Dubos, C Ducci, L Dwarkadas, V V Ebr, J Eckner, C Egberts, K Einecke, S Elsässer, D Emery Department of Physics Tokai University 4-1-1 Kita-Kaname Hiratsuka Kanagawa 259-1292 Japan Institute for Cosmic Ray Research University of Tokyo 5-1-5 Kashiwa-no-ha Kashiwa Chiba 277-8582 Japan ETH Zürich Institute for Particle Physics and Astrophysics Otto-Stern-Weg 5 CH-8093 Zürich Switzerland INFN and Università degli Studi di Siena Dipartimento di Scienze Fisiche della Terra e dell’Ambiente (DSFTA) Sezione di Fisica Via Roma 56 I-53100 Siena Italy Université Paris-Saclay Université Paris Cité CEA CNRS AIM F-91191 Gif-sur-Yvette Cedex France FSLAC IRL 2009 CNRS/IAC E-38205 La Laguna Tenerife Spain University of Alabama Tuscaloosa Department of Physics and Astronomy Gallalee Hall Box 870324 Tuscaloosa AL 35487-0324 USA Université Côte d’Azur Observatoire de la Côte d’Azur CNRS Laboratoire Lagrange UF 06304 Nice France Laboratoire Leprince-Ringuet CNRS/IN2P3 École Polytechnique Institut Polytechnique de Paris F-91120 Palaiseau France Departament de Física Quàntica i Astrofísica Institut de Ciències del Cosmos Universitat de Barcelona IEEC-UB Martí i Franquès 1 E-08028 Barcelona Spain Instituto de Astrofísica de Andalucía-CSIC Glorieta de la Astronomía s/n E-18008 Granada Spain Institute for Computational Cosmology and Department of Physics Durham University South Road Durham DH1 3LE UK Pontificia Universidad Católica de Chile Av. Libertador Bernardo O’Higgins 340 8331150 Santiago Chile Universidad Nacional Autónoma de México Delegación Coyoacán 04510 Ciudad de México Mexico IPARCOS-UCM Instituto de Física de Partículas y del Cosmos and EMFTEL Department Universidad Complutense de Madrid E-28040 Madrid Spain Instituto de Física Teórica UAM/CSIC and Departamento de Física Teórica Universidad Autónoma de Madrid c/ Nicolás Cabrera 13-15 Campus de Cantoblanco UAM E-28049 Madrid Spain LUTH GEPI and LERMA Observatoire de Paris Université PSL Université Paris Cité CNRS 5 place Jules Janssen F-92190 Meudon France INAF – Osservatorio

A wide variety of Galactic sources show transient emission at soft and hard X-ray energies: low- and high-mass X-ray binaries containing compact objects, isolated neutron stars exhibiting extreme variability as magnetars as well as pulsar-wind nebulae. Although most of them can show emission up to MeV and/or GeV energies, many have not yet been detected in the TeV domain by Imaging Atmospheric Cherenkov Telescopes. In this paper, we explore the feasibility of detecting new Galactic transients with the Cherenkov Telescope Array Observatory (CTAO) and the prospects for studying them with Target of Opportunity observations. We show that CTAO will likely detect new sources in the TeV regime, such as the massive microquasars in the Cygnus region, low-mass X-ray binaries with low-viewing angle, flaring emission from the Crab pulsar-wind nebula or other novae explosions, among others. Since some of these sources could also exhibit emission at larger time-scales, we additionally test their detectability at longer exposures. We finally discuss the multiwavelength synergies with other instruments and large astronomical facilities.

关键词： binaries: general stars: magnetars novae cataclysmic variables pulsars: general gamma-rays: general

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Detection of RS Oph with LST-1 and modelling of its HE/VHE gamma-ray emission

arXiv

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arXiv 2025年

作者： Abe, K. Abe, S. Abhishek, A. Acero, F. Aguasca-Cabot, A. Agudo, I. Alispach, C. Crespo, N. Alvarez Ambrosino, D. Antonelli, L.A. Aramo, C. Arbet-Engels, A. Arcaro, C. Asano, K. Aubert, P. Baktash, A. Balbo, M. Bamba, A. Larriva, A. Baquero de Almeida, U. Barres Barrio, J.A. Jiménez, L. Barrios Batkovic, I. Baxter, J. González, J. Becerra Bernardini, E. Bernete, J. Berti, A. Bezshyiko, I. Bhattacharjee, P. Bigongiari, C. Bissaldi, E. Blanch, O. Bonnoli, G. Bordas, P. Borkowski, G. Brunelli, G. Bulgarelli, A. Bunse, M. Burelli, I. Burmistrov, L. Buscemi, M. Cardillo, M. Caroff, S. Carosi, A. Carrasco, M.S. Cassol, F. Castrejón, N. Cerasole, D. Ceribella, G. Chai, Y. Cheng, K. Chiavassa, A. Chikawa, M. Chon, G. Chytka, L. Cicciari, G.M. Cifuentes, A. Contreras, J.L. Cortina, J. Costantini, H. Da Vela, P. Dalchenko, M. Dazzi, F. De Angelis, A. de Bony de Lavergne, M. De Lotto, B. de Menezes, R. Del Burgo, R. Del Peral, L. Delgado, C. Delgado Mengual, J. della Volpe, D. Dellaiera, M. Di Piano, A. Di Pierro, F. Di Tria, R. Di Venere, L. Díaz, C. Dominik, R.M. Dominis Prester, D. Donini, A. Dore, D. Dorner, D. Doro, M. Eisenberger, L. Elsässer, D. Emery, G. Escudero, J. Fallah Ramazani, V. Ferrarotto, F. Fiasson, A. Foffano, L. Freixas Coromina, L. Fröse, S. Fukazawa, Y. Garcia López, R. Gasbarra, C. Gasparrini, D. Geyer, D. Giesbrecht Paiva, J. Giglietto, N. Giordano, F. Gliwny, P. Godinovic, N. Grau, R. Green, D. Green, J. Gunji, S. Günther, P. Hackfeld, J. Hadasch, D. Hahn, A. Hassan, T. Hayashi, K. Heckmann, L. Heller, M. Herrera Llorente, J. Hirotani, K. Hoffmann, D. Horns, D. Houles, J. Hrabovsky, M. Hrupec, D. Hui, D. Iarlori, M. Imazawa, R. Inada, T. Inome, Y. Inoue, S. Ioka, K. Iori, M. Iuliano, A. Jahanvi, J. Jimenez Martinez, I. Jimenez Quiles, J. Jurysek, J. Kagaya, M. Kalashev, O. Karas, V. Katagiri, H. Kataoka, J. Kerszberg, D. Kobayashi, Y. Kohri, K. Kong, A. Kubo, H. Kushida, J. Lacave, B. Lainez, M. Lamanna, G. Lamastra, A. Lemoigne, L. Department of Physics Tokai University 4-1-1 Kita-Kaname Kanagawa Hiratsuka259-1292 Japan Institute for Cosmic Ray Research University of Tokyo 5-1-5 Kashiwa-no-ha Chiba Kashiwa277-8582 Japan Sezione di Fisica Via Roma 56 Siena53100 Italy Université Paris-Saclay Université Paris Cité CEA CNRS AIM Gif-sur-YvetteF-91191 Cedex France FSLAC IRL 2009 CNRS/IAC Tenerife La Laguna Spain Departament de Física Quàntica i Astrofísica Institut de Ciències del Cosmos Universitat de Barcelona IEEC-UB Martí i Franquès 1 Barcelona08028 Spain Instituto de Astrofísica de Andalucía-CSIC Glorieta de la Astronomía s/n Granada18008 Spain Department of Astronomy University of Geneva Chemin d’Ecogia 16 VersoixCH-1290 Switzerland IPARCOS-UCM Instituto de Física de Partículas y del Cosmos EMFTEL Department Universidad Complutense de Madrid Ciudad Universitaria Plaza de Ciencias 1 Madrid28040 Spain INFN Sezione di Napoli Via Cintia ed. G Napoli80126 Italy INAF - Osservatorio Astronomico di Roma Via di Frascati 33 Monteporzio Catone00040 Italy Max-Planck-Institut für Physik Föhringer Ring 6 München80805 Germany INFN Sezione di Padova Università degli Studi di Padova Via Marzolo 8 Padova35131 Italy Univ. Savoie Mont Blanc CNRS Laboratoire d’Annecy de Physique des Particules - IN2P3 Annecy74000 France Universität Hamburg Institut für Experimentalphysik Luruper Chaussee 149 Hamburg22761 Germany Graduate School of Science University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo113-0033 Japan Faculty of Science and Technology Universidad del Azuay Cuenca Ecuador Centro Brasileiro de Pesquisas Físicas Rua Xavier Sigaud 150 RJ Rio de Janeiro22290-180 Brazil Instituto de Astrofísica de Canarias Departamento de Astrofísica Universidad de La Laguna C. Vía Láctea s/n Santa Cruz de Tenerife La Laguna38205 Spain CIEMAT Avda. Complutense 40 Madrid28040 Spain University of Geneva Département de physique nucléaire et corpusculaire 24 Quai Ernest Ansernet

Context. The recurrent nova RS Ophiuchi (RS Oph) underwent a thermonuclear eruption in August 2021. In this event, RS Oph was detected by the High Energy Stereoscopic System (H.E.S.S.), the Major Atmospheric Gamma Imaging Cherenkov (MAGIC), and the first Large-Sized Telescope (LST-1) of the future Cherenkov Telescope Array Observatory (CTAO) at very-high gamma-ray energies above 100 GeV. This means that novae are a new class of very-high-energy (VHE) gamma-ray emitters. Aims. We report the analysis of the RS Oph observations with LST-1. We constrain the particle population that causes the observed emission in hadronic and leptonic scenarios. Additionally, we study the prospects of detecting further novae using LST-1 and the upcoming LST array of CTAO-North. Methods. We conducted target-of-opportunity observations with LST-1 from the first day of this nova event. The data were analysed in the framework of cta-lstchain and Gammapy, the official CTAO-LST reconstruction and analysis packages. One-zone hadronic and leptonic models were considered to model the gamma-ray emission of RS Oph using the spectral information from Fermi-LAT and LST-1, together with public data from the MAGIC and H.E.S.S. telescopes. Results. RS Oph was detected at 6.6σ with LST-1 in the first 6.35 hours of observations following the eruption. The hadronic scenario is preferred over the leptonic scenario considering a proton energy spectrum with a power-law model with an exponential cutoff whose position increases from (0.26 ± 0.08) TeV on day 1 up to (1.6 ± 0.6) TeV on day 4 after the eruption. The deep sensitivity and low energy threshold of the LST-1/LST array will allow us to detect faint novae and increase their discovery rate. © 2025, CC BY.

关键词： Gamma radiography

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Single-inductor dual-output DC-DC converter design using RC ripple regulator method

IEEJ Transactions on Electronics, Information and Systems

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IEEJ Transactions on Electronics, Information and Systems 2016年第2期136卷 101-107页

作者： Takai, Nobukazu Tanaka, Shunsuke Kobori, Yasunori Kobayashi, Haruo Devition of Electronics and Inormation Graduate School of Science and Technology Gunma University 1-5-1 Tenjin-cho Kiryu Gunma376-8515 Japan Education Program of Electronics and Informatics Graduate School of Science and Technology Gunma University 1-5-1 Tenjin-cho Kiryu Gunma376-8515 Japan National Institute of Technology Oyama College Dep. of Innovative Electrical and Electronic Engineering 771 Ohaza-Nakakuki Oyama Tochigi323-0806 Japan

In this paper, we have proposed Single Inductor Dual Output (SIDO) buck-buck and boost-boost DC-DC converter using improved RC ripple regulator control. The proposed SIDO buck-buck converter has the characteristics of lowripple and high control frequency. RC ripple regulator control can not be applied to SIDO boost-boost converter because RC ripple regulator undergoes self-excited oscillation and two self-excited oscillating controllers make the SIDO converter unstable. Thus we proposed the priority circuit for RC ripple regulator control. The proposed control circuit improves response characteristic and simplicity of the control circuit. Simulations are performed to verify the validity of the proposed SIDO converter. Simulation results indicate good performance of the proposed SIDO converter. © 2016 The Institute of Electrical Engineers of Japan.

关键词： Boost converter

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EMI reduction technique for switching converter by spectrum spread using pseudo analog signal

IEEJ Transactions on Electronics, Information and Systems

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IEEJ Transactions on Electronics, Information and Systems 2016年第1期136卷 43-49页

作者： Takai, Nobukazu Kaneya, Kotaro Kobori, Yasunori Kobayashi, Haruo Devition of Electronics and Inormation Graduate School of Science and Technology Gunma University 1-5-1 Tenjin-cho Kiryu Gunma376-8515 Japan Education Program of Electronics and Informatics Graduate School of Science and Technology Gunma University 1-5-1 Tenjin-cho Kiryu Gunma376-8515 Japan National Institute of Technology Oyama College Dep. of Innovative Electrical and Electronic Engineering 771 Ohaza-Nakakuki Oyama Tochigi323-0806 Japan

In this paper, EMI reduction method for switching power supply circuit by using PLL circuit as reference signal whose spectrum is spreaded, is proposed. M-sequence pseudo random signal is employed for PLL spectrum spread. Next, we extend this low bit M-sequence pseudo random signal to spectrum spread signal called "pseudo analog signal." The proposed pseudo analog signal can realize that the effect of the spectrum spread is wide even if the number of bit of the pseudo random circuit is small. Simulations and measurement are performed to verify the validity of the proposed method. Simulation and measurement results indicate that the proposed method have a large effect of the spectrum spread. © 2016 The Institute of Electrical Engineers of Japan.

关键词： Phase locked loops

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Development of a backdrivable magnetorheological hydraulic piston for passive and active linear actuation

Development of a backdrivable magnetorheological hydraulic p...

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IEEE/RSJ International Conference on Intelligent Robots and Systems

作者： G. A. Dominguez M. Kamezaki M. French S. Sugano Graduate Program for Embodiment Informatics for Leading Graduate Schools Japan Research Institute for Science and Engineering (RISE) Waseda University Tokyo Japan Graduate Program for Embodiment Informatics for Leading Graduate Schools Waseda University Tokyo Japan Department of Modern Mechanical Engineering Waseda University Shinjuku-ku Tokyo Japan

A new design of a magnetorheological piston prototype intended for passive or active force control in robotic applications for human robot interaction is introduced. It is based in a novel toroidal array of valves, contained within the piston head, which are used to control the output force of the actuator in order to achieve a high degree of reliability, size efficiency, and safety, by exploiting the material properties of magnetorheological fluids and permalloy metals. This paper describes the main points in the development of the magnetorheological piston prototype, the mathematical modelling of the magnetic circuit, and the results of the experiments conducted using a universal testing machine to evaluate the passive performance of the prototype. Results show the feasibility and performance of the new toroidal magnetic circuit of the magnetorheological hydraulic piston prototype. Improvements in order to be able to test the active performance of the design together with a pump setup are proposed.

关键词： Pistons Toroidal magnetic fields Magnetomechanical effects Magnetic heads Actuators Magnetic circuits Valves

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Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

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The Lancet 2020年第10258期396卷 1204-1222页

作者： Abbafati, Cristiana Abbas, Kaja M. Abbasi, Mohammad Abbasifard, Mitra Abbasi-Kangevari, Mohsen Abbastabar, Hedayat Abd-Allah, Foad Abdelalim, Ahmed Abdollahi, Mohammad Abdollahpour, Ibrahim Abedi, Aidin Abedi, Parisa Abegaz, Kedir Hussein Abolhassani, Hassan Abosetugn, Akine Eshete Aboyans, Victor Abrams, Elissa M. Abreu, Lucas Guimarães Abrigo, Michael R.M. Abu Haimed, Abdulaziz Khalid Abualhasan, Ahmed Abu-Gharbieh, Eman Abu-Raddad, Laith Jamal Abushouk, Abdelrahman I. Acebedo, Alyssa Ackerman, Ilana N. Adabi, Maryam Adair, Tim Adamu, Abdu A. Adebayo, Oladimeji M. Adedeji, Isaac Akinkunmi Adekanmbi, Victor Adelson, Jaimie D. Adeoye, Abiodun Moshood Adetokunboh, Olatunji O. Adham, Davoud Advani, Shailesh M. Afarideh, Mohsen Afshari, Mahdi Afshin, Ashkan Agardh, Emilie E. Agarwal, Gina Agasthi, Pradyumna Agesa, Kareha M. Aghaali, Mohammad Aghamir, Seyed Mohammad Kazem Agrawal, Anurag Ahmad, Tauseef Ahmadi, Alireza Ahmadi, Keivan Ahmadi, Mehdi Ahmadieh, Hamid Ahmadpour, Ehsan Ahmed, Muktar Beshir Aji, Budi Akalu, Temesgen Yihunie Akinyemi, Rufus Olusola Akinyemiju, Tomi Akombi, Blessing Akunna, Chisom Joyqueenet Alahdab, Fares Al-Aly, Ziyad Alam, Khurshid Alam, Noore Alam, Samiah Alam, Tahiya Alanezi, Fahad Mashhour Alanzi, Turki M. Albertson, Samuel B. Alcalde-Rabanal, Jacqueline Elizabeth Alema, Niguse Meles Alemu, Biresaw Wassihun Alemu, Yihun Mulugeta Alhabib, Khalid F. Alhassan, Robert Kaba Ali, Muhammad Ali, Saqib Alicandro, Gianfranco Alijanzadeh, Mehran Alinia, Cyrus Alipour, Vahid Alizade, Hesam Aljunid, Syed Mohamed Alla, François Allebeck, Peter Almadi, Majid Abdulrahman Hamad Almasi, Ali Almasi-Hashiani, Amir Almasri, Nihad A. Al-Mekhlafi, Hesham M. Almulhim, Abdulaziz M. Alonso, Jordi Al-Raddadi, Rajaa M. Altirkawi, Khalid A. Alumran, Arwa Khalid Alvis-Guzman, Nelson Alvis-Zakzuk, Nelson J. Amare, Azmeraw T. Amare, Bekalu Amini, Saeed Amini-Rarani, Mostafa Aminorroaya, Arya Amiri, Fatemeh Amit, Arianna Maever L. Amugsi, Dickson A. Amul, Gianna Gayle Herrera Anbesu, Etsay Woldu Ancuceanu, Robert Anderl Department of Juridical and Economic Studies La Sapienza University Rome Italy Department of Infectious Disease Epidemiology London School of Hygiene and Tropical Medicine London United Kingdom Social Determinants of Health Research Center Tehran Iran Department of Neurology Cairo University Cairo Egypt School of Pharmacy Tehran Iran The Institute of Pharmaceutical Sciences (TIPS) Tehran Iran Neuroscience Research Center Isfahan University of Medical Sciences Isfahan Iran Biostatistics Department Near East University Nicosia Cyprus Biostatistics and Health Informatics Madda Walabu University Bale Robe Ethiopia Research Center for Immunodeficiencies Tehran Iran Karolinska University Hospital Huddinge Sweden Department of Cardiology Dupuytren University Hospital Limoges France University of Limoges Limoges France Department of Pediatric Dentistry Federal University of Minas Gerais Belo Horizonte Brazil Department of Research Philippine Institute for Development Studies Quezon City Philippines Department of Healthcare Policy and Research Weill Cornell Medical College in Qatar Doha Qatar Harvard Medical School Boston MA United States Department of Medicine Ain Shams University Cairo Egypt Hamadan University of Medical Sciences Hamadan Iran School of Medicine Cardiff University Cardiff United Kingdom School of Laboratory Medicine and Science University College Hospital Ibadan Ibadan Nigeria Institute of Cardiovascular Diseases University of Ibadan Ibadan Nigeria Centre of Excellence for Epidemiological Modelling and Analysis Stellenbosch University Cape Town South Africa Department of Global Health Stellenbosch University Cape Town South Africa School of Health Ardabil University of Medical Science Ardabil Iran Social Behavioral Research Branch National Institute of Health Bethesda MD United States Department of Oncology Georgetown University Washington DC DC United States Department of Health Metrics Sciences School of Medicine Seattle WA

Background: In an era of shifting global agendas and expanded emphasis on non-communicable diseases and injuries along with communicable diseases, sound evidence on trends by cause at the national level is essential. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) provides a systematic scientific assessment of published, publicly available, and contributed data on incidence, prevalence, and mortality for a mutually exclusive and collectively exhaustive list of diseases and injuries. Methods: GBD estimates incidence, prevalence, mortality, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs) due to 369 diseases and injuries, for two sexes, and for 204 countries and territories. Input data were extracted from censuses, household surveys, civil registration and vital statistics, disease registries, health service use, air pollution monitors, satellite imaging, disease notifications, and other sources. Cause-specific death rates and cause fractions were calculated using the Cause of Death Ensemble model and spatiotemporal Gaussian process regression. Cause-specific deaths were adjusted to match the total all-cause deaths calculated as part of the GBD population, fertility, and mortality estimates. Deaths were multiplied by standard life expectancy at each age to calculate YLLs. A Bayesian meta-regression modelling tool, DisMod-MR 2.1, was used to ensure consistency between incidence, prevalence, remission, excess mortality, and cause-specific mortality for most causes. Prevalence estimates were multiplied by disability weights for mutually exclusive sequelae of diseases and injuries to calculate YLDs. We considered results in the context of the Socio-demographic Index (SDI), a composite indicator of income per capita, years of schooling, and fertility rate in females younger than 25 years. Uncertainty intervals (UIs) were generated for every metric using the 25th and 975th ordered 1000 draw value

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Mapping geographical inequalities in childhood diarrhoeal morbidity and mortality in low-income and middle-income countries, 2000-17: analysis for the Global Burden of Disease Study 2017 (vol 395, pg 1779, 2020)

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LANCET 2020年第10239期395卷 1762-1762页

作者： Reiner, R. C., Jr. Hay, S., I Institute for Health Metrics and Evaluation University of Washington Seattle WA United States Department of Global Health School of Medicine University of Washington Seattle WA United States Department of Health Metrics Sciences School of Medicine University of Washington Seattle WA United States College of Health and Medical Sciences Haramaya University Harar Ethiopia Department of Epidemiology and Biostatistics Haramaya University Harar Ethiopia Department of Medical Laboratory Sciences Haramaya University Harar Ethiopia School of Nursing and Midwifery Haramaya University Harar Ethiopia School of Pharmacy Haramaya University Harar Ethiopia School of Public Health Haramaya University Harar Ethiopia Haramaya University Harar Ethiopia Advanced Diagnostic and Interventional Radiology Research Center Tehran University of Medical Sciences Tehran Iran Cancer Biology Research Center Tehran University of Medical Sciences Tehran Iran Cancer Research Institute Tehran University of Medical Sciences Tehran Iran Department of Economics and Management Sciences for Health Tehran University of Medical Sciences Tehran Iran Department of Environmental Health Engineering Tehran University of Medical Sciences Tehran Iran Department of Epidemiology and Biostatistics Tehran University of Medical Sciences Tehran Iran Department of Health Management and Economics Tehran University of Medical Sciences Tehran Iran Department of Microbiology Tehran University of Medical Sciences Tehran Iran Department of Pharmacology Tehran University of Medical Sciences Tehran Iran Digestive Diseases Research Institute Tehran University of Medical Sciences Tehran Iran Endocrinology and Metabolism Research Center Tehran University of Medical Sciences Tehran Iran Hematology-Oncology and Stem Cell Transplantation Research Center Tehran University of Medical Sciences Tehran Iran Iran National Institute of Health Research Tehran University of Medical Sciences Tehran Iran Metabolomics and

Summary Background Across low-income and middle-income countries (LMICs), one in ten deaths in children younger than 5 years is attributable to diarrhoea. The substantial between-country variation in both diarrhoea incidence and mortality is attributable to interventions that protect children, prevent infection, and treat disease. Identifying subnational regions with the highest burden and mapping associated risk factors can aid in reducing preventable childhood *** We used Bayesian model-based geostatistics and a geolocated dataset comprising 15 072 746 children younger than 5 years from 466 surveys in 94 LMICs, in combination with findings of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017, to estimate posterior distributions of diarrhoea prevalence, incidence, and mortality from 2000 to 2017. From these data, we estimated the burden of diarrhoea at varying subnational levels (termed units) by spatially aggregating draws, and we investigated the drivers of subnational patterns by creating aggregated risk factor *** The greatest declines in diarrhoeal mortality were seen in south and southeast Asia and South America, where 54·0% (95% uncertainty interval [UI] 38·1-65·8), 17·4% (7·7-28·4), and 59·5% (34·2-86·9) of units, respectively, recorded decreases in deaths from diarrhoea greater than 10%. Although children in much of Africa remain at high risk of death due to diarrhoea, regions with the most deaths were outside Africa, with the highest mortality units located in Pakistan. Indonesia showed the greatest within-country geographical inequality; some regions had mortality rates nearly four times the average country rate. Reductions in mortality were correlated to improvements in water, sanitation, and hygiene (WASH) or reductions in child growth failure (CGF). Similarly, most high-risk areas had poor WASH, high CGF, or low oral rehydration therapy *** By co-analysing geospatial trends in d

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Multiwavelength variability and correlation studies of Mrk 421 during historically low X-ray and γ-ray activity in 2015–2016

arXiv

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arXiv 2020年

作者： Acciari, V.A. Ansoldi, S. Antonelli, L.A. Asano, K. Babić, A. Banerjee, Biswajit Baquero, A. Barres De Almeida, U. Barrio, J.A. Becerra González, J. Bednarek, W. Bellizzi, L. Bernardini, E. Bernardos, M. Berti, A. Besenrieder, J. Bhattacharyya, W. Bigongiari, C. Blanch, O. Bonnoli, G. Bošnjak, Ž. Busetto, G. Carosi, R. Ceribella, G. Cerruti, M. Chai, Y. Chilingarian, A. Cikota, S. Colak, S.M. Colombo, E. Contreras, J.L. Cortina, J. Covino, S. D’Amico, G. D’Elia, V. Da Vela, P. Dazzi, F. De Angelis, A. De Lotto, B. Delfino, M. Delgado, J. Delgado Mendez, C. Depaoli, D. Di Girolamo, T. Di Pierro, F. Di Venere, L. Do Souto Espiñeira, E. Dominis Prester, D. Donini, A. Doro, M. Fallah Ramazani, V. Fattorini, A. Ferrara, G. Foffano, L. Fonseca, M.V. Font, L. Fruck, C. Fukami, S. García López, R.J. Garczarczyk, M. Gasparyan, S. Gaug, M. Giglietto, N. Giordano, F. Gliwny, P. Godinović, N. Green, J.G. Green, D. Hadasch, D. Hahn, A. Heckmann, L. Herrera, J. Hoang, J. Hrupec, D. Hütten, M. Inada, T. Inoue, S. Ishio, K. Iwamura, Y. Jormanainen, J. Jouvin, L. Kajiwara, Y. Karjalainen, M. Kerszberg, D. Kobayashi, Y. Kubo, H. Kushida, J. Lamastra, A. Lelas, D. Leone, F. Lindfors, E. Lombardi, S. Longo, F. López, M. López-Coto, R. López-Oramas, A. Loporchio, S. Machado De Oliveira Fraga, B. Maggio, C. Majumdar, P. Makariev, M. Mallamaci, M. Maneva, G. Manganaro, M. Maraschi, L. Mariotti, M. Martínez, M. Mazin, D. Mender, S. Mićanović, S. Miceli, D. Miener, T. Minev, M. Miranda, J.M. Mirzoyan, R. Molina, E. Moralejo, A. Morcuende, D. Moreno, V. Moretti, E. Munar-Adrover, P. Neustroev, V. Nigro, C. Nilsson, K. Ninci, D. Nishijima, K. Noda, K. Nozaki, S. Ohtani, Y. Oka, T. Otero-Santos, J. Palatiello, M. Paneque, D. Paoletti, R. Paredes, J.M. Pavletić, L. Peñil, P. Perennes, C. Persic, M. Prada Moroni, P.G. Prandini, E. Priyadarshi, C. Puljak, I. Inst. de Astrofísica de Canarias La LagunaE-38200 Spain Universidad de La Laguna Dpto. Astrofísica Tenerife La LagunaE-38206 Spain Università di Udine INFN Trieste UdineI-33100 Italy RomeI-00136 Italy Japanese MAGIC Consortium ICRR The University of Tokyo Chiba277-8582 Japan Department of Physics Kyoto University Kyoto606-8502 Japan Tokai University Kanagawa259-1292 Japan Physics Program Graduate School of Advanced Science and Engineering Hiroshima University Hiroshima739-8526 Japan Konan University Hyogo658-8501 Japan RIKEN Saitama351-0198 Japan Technische Universität Dortmund DortmundD-44221 Germany Croatian Consortium: University of Rijeka Department of Physics Rijeka51000 Croatia University of Split - FESB Split21000 Croatia University of Zagreb - FER Zagreb10000 Croatia University of Osijek Osijek31000 Croatia Rudjer Boskovic Institute Zagreb10000 Croatia IPARCOS Institute EMFTEL Department Universidad Complutense de Madrid MadridE-28040 Spain URCA RJ Rio de Janeiro22290-180 Brazil University of Lodz Faculty of Physics and Applied Informatics Department of Astrophysics Lodz90-236 Poland Università di Siena and INFN Pisa SienaI-53100 Italy ZeuthenD-15738 Germany Centro de Investigaciones Energéticas Medioambientales y Tecnológicas MadridE-28040 Spain Frascati Roma00044 Italy Max-Planck-Institut für Physik MünchenD-80805 Germany Bellaterra BarcelonaE-08193 Spain Università di Padova INFN PadovaI-35131 Italy Università di Pisa INFN Pisa PisaI-56126 Italy Universitat de Barcelona ICCUB IEEC-UB BarcelonaE-08028 Spain The Armenian Consortium: ICRANet-Armenia at NAS RA A. Alikhanyan National Laboratory Universität Würzburg WürzburgD-97074 Germany University of Turku TurkuFI-20014 Finland Astronomy Research Unit University of Oulu OuluFI-90014 Finland Departament de Física CERES-IEEC Universitat Autònoma de Barcelona Bellaterra E-08193 Spain Saha Institute of Nuclear Physics HBNI 1/AF Bi

We report a characterization of the multi-band flux variability and correlations of the nearby (z=0.031) blazar Markarian 421 (Mrk 421) using data from Metsähovi, Swift, Fermi-LAT, MAGIC, FACT and other collaborations and instruments from November 2014 till June 2016. Mrk 421 did not show any prominent flaring activity, but exhibited periods of historically low activity above 1 TeV (F>1TeV -12 ph cm-2 s-1) and in the 2-10 keV (X-ray) band (F2-10 keV -11 erg cm-2 s-1), during which the Swift-BAT data suggests an additional spectral component beyond the regular synchrotron *** highest flux variability occurs in X-rays and very-high-energy (E>0.1 TeV) γ-rays, which, despite the low activity, show a significant positive correlation with no time lag. The HRkeV and HRTeV show the harder-when-brighter trend observed in many blazars, but the trend flattens at the highest fluxes, which suggests a change in the processes dominating the blazar variability. Enlarging our data set with data from years 2007 to 2014, we measured a positive correlation between the optical and the GeV emission over a range of about 60 days centered at time lag zero, and a positive correlation between the optical/GeV and the radio emission over a range of about 60 days centered at a time lag of 43+-96 *** observation is consistent with the radio-bright zone being located about 0.2 parsec downstream from the optical/GeV emission regions of the jet. The flux distributions are better described with a LogNormal function in most of the energy bands probed, indicating that the variability in Mrk 421 is likely produced by a multiplicative process. Copyright © 2020, The Authors. All rights reserved.

关键词： Optical correlation

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