The purpose of this paper is to introduce a form of update based on the minimization of the geodesic distance on a graph. We provide a characterization of this class using set-theoretic operators and show that such op...
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Chemical reaction networks by which individual cells gather and process information about their chemical environments have been dubbed "signal transduction" networks. Despite this suggestive terminology, the...
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ISBN:
(纸本)9780262195683
Chemical reaction networks by which individual cells gather and process information about their chemical environments have been dubbed "signal transduction" networks. Despite this suggestive terminology, there have been few attempts to analyze chemical signaling systems with the quantitative tools of information theory. Gradient sensing in the social amoeba Dictyostelium discoideum is a well characterized signal transduction system in which a cell estimates the direction of a source of diffusing chemoattractant molecules based on the spatiotemporal sequence of ligand-receptor binding events at the cell membrane. Using Monte Carlo techniques (MCell) we construct a simulation in which a collection of individual ligand particles undergoing Brownian diffusion in a three-dimensional volume interact with receptors on the surface of a static amoeboid cell. Adapting a method for estimation of spike train entropies described by Victor (originally due to Kozachenko and Leonenko), we estimate lower bounds on the mutual information between the transmitted signal (direction of ligand source) and the received signal (spatiotemporal pattern of receptor binding/unbinding events). Hence we provide a quantitative framework for addressing the question: how much could the cell know, and when could it know it? We show that the time course of the mutual information between the cell's surface receptors and the (unknown) gradient direction is consistent with experimentally measured cellular response times. We find that the acquisition of directional information depends strongly on the time constant at which the intracellular response is filtered.
With support from HBCU-UP (Historically Black College and University Undergraduateprogram) at National science Foundation (NSF), the ACTION (Advanced Curriculum and Technology-Based Instructional Opportunities Networ...
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We give a straightforward computable-model-theoretic definition of a property of Δ02 sets called order-computability. We then prove various results about these sets which suggest that, simple though the definition is...
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Chemical reaction networks by which individual cells gather and process information about their chemical environments have been dubbed "signal transduction" networks. Despite this suggestive terminology, the...
Chemical reaction networks by which individual cells gather and process information about their chemical environments have been dubbed "signal transduction" networks. Despite this suggestive terminology, there have been few attempts to analyze chemical signaling systems with the quantitative tools of information theory. Gradient sensing in the social amoeba Dictyostelium discoideum is a well characterized signal transduction system in which a cell estimates the direction of a source of diffusing chemoattractant molecules based on the spatiotemporal sequence of ligand-receptor binding events at the cell membrane. Using Monte Carlo techniques (MCell) we construct a simulation in which a collection of individual ligand particles undergoing Brownian diffusion in a three-dimensional volume interact with receptors on the surface of a static amoeboid cell. Adapting a method for estimation of spike train entropies described by Victor (originally due to Kozachenko and Leonenko), we estimate lower bounds on the mutual information between the transmitted signal (direction of ligand source) and the received signal (spatiotemporal pattern of receptor binding/unbinding events). Hence we provide a quantitative framework for addressing the question: how much could the cell know, and when could it know it? We show that the time course of the mutual information between the cell's surface receptors and the (unknown) gradient direction is consistent with experimentally measured cellular response times. We find that the acquisition of directional information depends strongly on the time constant at which the intracellular response is filtered.
作者:
Artemov, SergeiNogina, ElenaGraduate Center
CUNY Ph.D. Program in Computer Science 365 Fifth Avenue New York NY 10016 United States BMCC
CUNY Department of Mathematics 199 Chambers Street New York NY 10007 United States
The true belief components of Plato's tripartite definition of knowledge as justified true belief are represented in formal epistemology by modal logic and its possible worlds semantics. At the same time, the just...
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ISBN:
(纸本)9810534124
The true belief components of Plato's tripartite definition of knowledge as justified true belief are represented in formal epistemology by modal logic and its possible worlds semantics. At the same time, the justification component of Plato's definition did not have a formal representation. This paper introduces the notion of justification into formal epistemology. Epistemic logic with justification, along with the usual knowledge operator F (F is known), contains assertions t:F (t is a justification for F). We suggest an epistemic semantics which augments Kripke models with a natural Fitting-style treatment of justification assertions t:F. Completeness and some new specific properties of basic systems of epistemic logic with justification are established.
With the increase in adoption of remote work groups and teams working in non-collocated environments, several opportunities for interaction have been lost. Contact with colleagues and discovery of opportunities, previ...
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With the increase in adoption of remote work groups and teams working in non-collocated environments, several opportunities for interaction have been lost. Contact with colleagues and discovery of opportunities, previously easy due to physical proximity, is made harder with distance. In this paper, we describe an agent-based framework to assist users in finding opportunities for interaction that may have been overlooked.
作者:
Vivacqua, Ade Souza, JComputer Science Program
Graduate School Engineering Federal University of Rio de Janeiro Rio de Janeiro Brazil DCC
Institute of Mathematics Federal University of Rio de Janeiro Rio de Janeiro Brazil
Creativity has become an important asset in today's fast changing environment. It is especially important in design, which demands innovative solutions for every project. We believe that creativity can and should ...
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ISBN:
(纸本)0780379411
Creativity has become an important asset in today's fast changing environment. It is especially important in design, which demands innovative solutions for every project. We believe that creativity can and should be encouraged in work groups. In this paper, we propose a framework for supporting creativity in problem solving. Through the use of problem, domain and user models and information retrieval and agent technology, we hope to support creative cooperative work.
Creativity has become an important asset in today'sfast changing environment. It is especially important indesign, which demands innovative solutions for *** believe that creativity can and should beencouraged in ...
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Creativity has become an important asset in today'sfast changing environment. It is especially important indesign, which demands innovative solutions for *** believe that creativity can and should beencouraged in work groups. In this paper, we proposea framework for supporting creativity in problemsolving. Through the use of problem, domain and usermodels and information retrieval and agent technology,we hope to support creative cooperative work.
In this paper, we start from a case study of an architecture company and move on to a framework of agents to identify and inform conceptual design. The processes and problems exhibited by the company involved are quit...
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