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science Signaling Podcast: 1 January 2013

science Signaling 2013年第256期6卷 pc1页

作者： Arthur Weiss Jayajit Das Annalisa M. VanHook The Rosalind Russell Research Center for Arthritis Department of Medicine Howard Hughes Medical Institute University of California San Francisco CA 94143 USA. Battelle Center for Mathematical Medicine The Research Institute at Nationwide Children's Hospital Biophysics Graduate Program and Departments of Pediatrics and Physics The Ohio State University Columbus OH 43205 USA. Web Editor Science Signaling American Association for the Advancement of Science 1200 New York Avenue NW Washington DC 20005 USA.

This Podcast features an interview Arthur Weiss and Jayajit Das, senior authors of a research Article that appears in this issue of science Signaling. Signaling through the B cell receptor (BCR) may be induced by monomeric or multimeric ligands and requires kinases of both the Src and Syk family. A group led by Weiss and Das used mathematical modeling to address the roles of these two kinases in B cell receptor signaling. Their findings, which were experimentally validated in cells, indicated that Syk was sufficient to mediate signaling initiated by multimeric ligands, which induce BCR clustering. However, both kinases were required to mediate signaling initiated by monomeric ligands, which do not induce BCR clustering.

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Prior COVID-19 vaccination and reduced risk of cerebrovascular diseases among COVID-19 survivors

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Journal of medical Virology 2024年第5期96卷 e29648-e29648页

作者： Chen, Sheng-Yin Hsieh, Tina Yi Jin Hung, Yao-Min Oh, Jae Won Chen, Shen-Kai Wang, Shiow-Ing Chang, Renin Wei, James Cheng-Chung Clinical and Translational Epidemiology Unit Massachusetts General Hospital and Harvard Medical School Boston Morocco Division of Gastroenterology Massachusetts General Hospital and Harvard Medical School Boston Morocco Department of Epidemiology Harvard T. H. Chan School of Public Health Boston Morocco Department of Obstetrics & Gynecology Beth Israel Deaconess Medical Center Boston Morocco Department of Bioinformatics Harvard Medical School Boston Morocco Division of Nephrology Department of Internal Medicine Taipei Veterans General Hospital Taitung Branch Taiwan Master Program in Biomedicine College of Science and Engineering National Taitung University Taitung Taiwan College of Health and Nursing Meiho University Pingtung Taiwan Department of Neurology Brigham and Women's Hospital Boston Morocco Department of Neurology Harvard Medical School Boston MA United States Department of Education Kaohsiung Chang Gung Memorial Hospital Boston MA United States Center for Health Data Science Department of Medical Research Chung Shan Medical University Hospital Taichung Taiwan Institute of Medicine College of Medicine Chung Shan Medical University Taichung Taiwan Department of Nursing Jen-Teh Junior College of Medicine Nursing and Management Miaoli County Taiwan Department of Medical Education and Research Kaohsiung Veterans General Hospital Kaohsiung Taiwan Department of Emergency Medicine Kaohsiung Veterans General Hospital Kaohsiung Taiwan School of Medicine Chung Shan Medical University Taichung Taiwan Department of Recreation and Sports Management Tajen University Pintung Taiwan Department of Allergy Immunology & Rheumatology Chung Shan Medical University Hospital Taichung Taiwan Department of Nursing Chung Shan Medical University Taichung Taiwan Graduate Institute of Integrated Medicine China Medical University Taichung Taiwan Office of Research and Development Asia University Taichung Taiwan

The effects of COVID-19 vaccination on short-term and long-term cerebrovascular risks among COVID-19 survivors remained unknown. We conducted a national multi-center retrospective cohort study with 151 597 vaccinated and 151 597 unvaccinated COVID-19 patients using the TriNetX database, from January 1, 2020 to December 31, 2023. Patients baseline characteristics were balanced with propensity score matching (PSM). The outcomes were incident cerebrovascular diseases occurred between 1st and 30th days (short-term) after COVID-19 diagnosis. Nine subgroup analyses were conducted to explore potential effect modifications. We performed six sensitivity analyses, including evaluation of outcomes between 1st to 180th days, accounting for competing risk, and incorporating different variant timeline to test the robustness of our results. Kaplan-Meier curves and Log-Rank tests were performed to evaluate survival difference. Cox proportional hazards regressions were adopted to estimate the PSM-adjusted hazard ratios (HR). The overall short-term cerebrovascular risks were lower in the vaccinated group compared to the unvaccinated group (HR: 0.66, 95% CI: 0.56–0.77), specifically cerebral infarction (HR: 0.62, 95% CI: 0.48–0.79), occlusion and stenosis of precerebral arteries (HR: 0.74, 95% CI: 0.53–0.98), other cerebrovascular diseases (HR: 0.57, 95% CI: 0.42–0.77), and sequelae of cerebrovascular disease (HR: 0.39, 95% CI:0.23–0.68). Similarly, the overall cerebrovascular risks were lower in those vaccinated among most subgroups. The long-term outcomes, though slightly attenuated, were consistent (HR: 0.80, 95% CI: 0.73–0.87). Full 2-dose vaccination was associated with a further reduced risk of cerebrovascular diseases (HR: 0.63, 95% CI: 0.50–0.80) compared to unvaccinated patients. Unvaccinated COVID-19 survivors have significantly higher cerebrovascular risks than their vaccinated counterparts. Thus, clinicians are recommended to monitor this population closely for stroke even

关键词： cohort study COVID-19 vaccination strokes

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Worldwide Soundscapes: A Synthesis of Passive Acoustic Monitoring Across Realms

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Global Ecology and Biogeography 2025年第5期34卷

作者： Kevin F. A. Darras Rodney A. Rountree Steven L. Van Wilgenburg Anna F. Cord Frederik Pitz Youfang Chen Lijun Dong Agnès Rocquencourt Camille Desjonquères Patrick Mauritz Diaz Tzu-Hao Lin Théophile Turco Louise Emmerson Tom Bradfer-Lawrence Amandine Gasc Sarah Marley Marcus Salton Laura Schillé Paul J. Wensveen Shih-Hung Wu Adriana C. Acero-Murcia Orlando Acevedo-Charry Matyáš Adam Jacopo Aguzzi Irmak Akoglu M. Clara P. Amorim Mina Anders Michel André Alexandre Antonelli Leandro Aparecido Do Nascimento Giulliana Appel Stephanie Archer Christos Astaras Andrey Atemasov Jamieson Atkinson Joël Attia Emanuel Baltag Luc Barbaro Fritjof Basan Carly Batist Julio Ernesto Baumgarten Just T. Bayle Sempere Kristen Bellisario Asaf Ben David Oded Berger-Tal Frédéric Bertucci Matthew G. Betts Iqbal S. Bhalla Thiago Bicudo Marta Bolgan Sara Bombaci Gerard Bota Martin Boullhesen Robert A. Briers Susannah Buchan Michal Budka Katie Burchard Giuseppa Buscaino Alice Calvente Marconi Campos-Cerqueira Maria Isabel Carvalho Gonçalves Maria Ceraulo Maite Cerezo-Araujo Gunnar Cerwén Adams A. Chaskda Maria Chistopolova Christopher W. Clark Kieran D. Cox Benjamin Cretois Chapin Czarnecki Luis P. da Silva Wigna da Silva Laurence H. De Clippele David de la Haye Ana Silvia de Oliveira Tissiani Devin de Zwaan M. Eugenia Degano Jessica Deichmann Joaquin del Rio Christian Devenish Ricardo Díaz-Delgado Pedro Diniz Dorgival Diógenes Oliveira-Júnior Thiago Dorigo Saskia Dröge Marina Duarte Adam Duarte Kerry Dunleavy Robert Dziak Simon Elise Hiroto Enari Haruka S. Enari Florence Erbs Britas Klemens Eriksson Pınar Ertör-Akyazi Nina C. Ferrari Luane Ferreira Abram B. Fleishman Paulo J. Fonseca Bárbara Freitas Nicholas R. Friedman Jérémy S. P. Froidevaux Svetlana Gogoleva Carolina Gonzaga José Miguel González Correa Eben Goodale Benjamin Gottesman Ingo Grass Jack Greenhalgh Jocelyn Gregoire Samuel Haché Jonas Hagge William Halliday Antonia Hammer Tara Hanf-Dressler Sylvain Haupert Samara Haver Becky Heath Daniel Hending Jose Hernandez-Blanco Dennis Higgs EFNO ECODIV INRAE Domaine des Barres Nogent-sur-Vernisson France Sustainable Agricultural Systems & Engineering Lab School of Engineering Westlake University Hangzhou Zhejiang China Chair of Computational Landscape Ecology Faculty of Environmental Sciences Dresden University of Technology Dresden Germany Biology Department University of Victoria Victoria British Columbia Canada The Fish Listener Waguoit Massachusetts USA Terrestrial Unit Prairie Region Canadian Wildlife Service Environment & Climate Change Canada Prairie & Northern Wildlife Research Centre Saskatoon Saskatchewan Canada Agro-ecological Modeling Group Faculty of Agriculture University of Bonn Bonn Germany Marine Mammal and Marine Bioacoustics Laboratory Department of Deep Sea Science Institute of Deep-sea Science and Engineering Chinese Academy of Sciences Sanya Hainan China Institut de Systématique Évolution Biodiversité Muséum National d’Histoire Naturelle Paris France Université Grenoble Alpes Université Savoie Mont Blanc CNRS LECA Grenoble France Climate Change and Biodiversity Hanns R. Neumann Stiftung Indonesia Muaradua Indonesia Biodiversity Research Center Academia Sinica Nankang Taipei Taiwan ENES Bioacoustics Research Laboratory University of Saint-Etienne CRNL CNRS UMR 5292 Inserm UMR_S 1028 Saint-Etienne France Australian Antarctic Division Science Branch Department of Climate Change Energy Environment and Water Channel Highway Kingston Tasmania Australia Biological and Environmental Sciences University of Stirling Stirling Scotland Centre for Conservation Science RSPB Edinburgh UK IMBE Aix Marseille Univ Avignon Univ CNRS IRD Aix-en-Provence France Scotland's Rural College Craibstone Estate Aberdeen UK BIOGECO INRAE University of Bordeaux Cestas France Westman Islands Research Centre University of Iceland Vestmannaeyjar Iceland Qigu Research Center Taiwan Biodiversity Research Institute Nantou County Taiwan Programa de Pós-graduação em Ecologia

Aim The urgency for remote, reliable and scalable biodiversity monitoring amidst mounting human pressures on ecosystems has sparked worldwide interest in Passive Acoustic Monitoring (PAM), which can track life underwater and on land. However, we lack a unified methodology to report this sampling effort and a comprehensive overview of PAM coverage to gauge its potential as a global research and monitoring tool. To address this gap, we created the Worldwide Soundscapes project, a collaborative network and growing database comprising metadata from 416 datasets across all realms (terrestrial, marine, freshwater and subterranean). Location Worldwide, 12,343 sites, all ecosystem types. Time Period 1991 to present. Major Taxa Studied All soniferous taxa. Methods We synthesise sampling coverage across spatial, temporal and ecological scales using metadata describing sampling locations, deployment schedules, focal taxa and audio recording parameters. We explore global trends in biological, anthropogenic and geophysical sounds based on 168 selected recordings from 12 ecosystems across all realms. Results Terrestrial sampling is spatially denser (46 sites per million square kilometre—Mkm 2 ) than aquatic sampling (0.3 and 1.8 sites/Mkm 2 in oceans and fresh water) with only two subterranean datasets. Although diel and lunar cycles are well sampled across realms, only marine datasets (55%) comprehensively sample all seasons. Across the 12 ecosystems selected for exploring global acoustic trends, biological sounds showed contrasting diel patterns across ecosystems, declined with distance from the Equator, and were negatively correlated with anthropogenic sounds. Main Conclusions PAM can inform macroecological studies as well as global conservation and phenology syntheses, but representation can be improved by expanding terrestrial taxonomic scope, sampling coverage in the high seas and subterranean ecosystems, and spatio-temporal replication in freshwater habitats. Overall, this

关键词： ARU automated sound recorder biodiversity conservation biology ecoacoustics IUCN GET realm Passive Acoustic Monitoring phenology soundscape ecology

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STUDENT PRIZE PAPER: The Illnesses No Longer Understand: Changing Concepts of Health and Curing in a Rural Mexican Community

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medical Anthropology Quarterly 1977年第2期8卷 5-11页

作者： Kathleen Musante DeWalt Kathleen DeWalt is a fourth year graduate student in the Dept of Biocultural Anthropology Connecticut-Storrs and in the Social Sciences and Health Services Training Program in the Dept of Community Medicine and Health Care at the U Conn Health Center Farmington. She received her B.A. in 1971 and her M.A. in 1976 both in Anthropology from Connecticut. The work on which this paper is based was carried out in a village in the municipio of Temascalcingo between January and December 1973 about 11 months in all. She had first worked in the Temascalcingo area in summer 1970 supported by a National Science Foundation undergraduate research grant. In 1971 she began her graduate study in the Dept of Anthropology at Connecticut but decided to discontinue her studies at that time in order to be with her husband while he carried out his Ph.D. dissertation research on agricultural modernization in Mexico. During this period however Ms. DeWalt was able to carry out a preliminary study of her own which focused on medical behavior and diet. When she returned from the field she resumed her studies by entering the Social Sciences and Health Services Doctoral Training Program located in the Dept of Community Medicine at the U of Connecticut Health Center. Ms. DeWalt has just completed her Ph.D. qualifying examinations at Connecticut and plans to begin work on her dissertation shortly. Her dissertation will focus on the effects of economic diversification on diet and nutrition in the Temascalcingo area. While the research carried out thus far will serve as background and provide baseline data she expects to spend an additional 4–6 months in the field in 1977.

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Matched computed tomography segmentation and demographic data for oropharyngeal cancer radiomics challenges

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Scientific data 2017年第1期4卷 170077-170077页

作者： Hesham Elhalawani Abdallah S.R. Mohamed Aubrey L. White James Zafereo Andrew J. Wong Joel E. Berends Shady AboHashem Bowman Williams Jeremy M. Aymard Aasheesh Kanwar Subha Perni Crosby D. Rock Luke Cooksey Shauna Campbell Yao Ding Clifton D. Fuller Stephen Y. Lai Elisabeta G. Marai David Vock Guadalupe M. Canahuate John Freymann Keyvan Farahani Jayashree Kalpathy-Cramer Department of Radiation Oncology University of Texas MD Anderson Cancer Center Houston 77030 Texas USA Department of Clinical Oncology University of Alexandria Alexandria 21527 Egypt McGovern Medical School at University of Texas Health Science Center at Houston (UTHealth) Houston 77030 Texas USA University of Texas Health Science Center San Antonio 78229 Texas USA Department of Cardiology Harvard Medical School and Massachusetts General Hospital Boston 02115 Massachusetts USA Furman University Greenville 29613 South Carolina USA Abilene Christian University Abilene 79601 Texas USA Texas Tech University Health Sciences Center School of Medicine Lubbock 79905 Texas USA Columbia College of Physicians and Surgeons New York 10032 Massachusetts USA Texas Tech Health Sciences Center El Paso Paul L. Foster School of Medicine 79905 Texas USA Department of Radiation Oncology Cleveland Clinic Foundation Cleveland 44124 Ohio USA Department of Imaging Physic University of Texas MD Anderson Cancer Center Houston 77030 Texas USA Medical Physics Program University of Texas Graduate School of Biomedical Sciences Houston 77030 Texas USA Department of Head and Neck Surgery University of Texas MD Anderson Cancer Center Houston 77030 Texas USA Department of Computer Science University of Illinois at Chicago Chicago 60607 Illinois USA Department of Biostatistics University of Minnesota of Public Health Minneapolis 55455 Minnesota USA Department of Electrical & Computer Engineering University of Iowa Iowa City 52242 Iowa USA Leidos Biomedical Research Inc Frederick National Laboratory for Cancer Research Frederick 21701 Maryland USA The Russell H. Morgan Department of Radiology and Radiological Science Johns Hopkins Medical Institutions Baltimore 21287 Maryland USA National Cancer Institute National Institutes of Health Bethesda 20892 Maryland USA Department of Radiology and Athinoula A. Martinos Center for Biomedical Imaging Massachusetts Ge

Cancers arising from the oropharynx have become increasingly more studied in the past few years, as they are now epidemic domestically. These tumors are treated with definitive (chemo)radiotherapy, and have local recurrence as a primary mode of clinical failure. Recent data suggest that 'radiomics', or extraction of image texture analysis to generate mineable quantitative data from medical images, can reflect phenotypes for various cancers. Several groups have shown that developed radiomic signatures, in head and neck cancers, can be correlated with survival outcomes. This data descriptor defines a repository for head and neck radiomic challenges, executed via a Kaggle in Class platform, in partnership with the MICCAI society 2016 annual *** public challenges were designed to leverage radiomics and/or machine learning workflows to discriminate HPV phenotype in one challenge (HPV status challenge) and to identify patients who will develop a local recurrence in the primary tumor volume in the second one (Local recurrence prediction challenge) in a segmented, clinically curated anonymized oropharyngeal cancer (OPC) data set.

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Erratum to 'Relation Between Mitral Valve Prolapse and Erectile Dysfunction (from a Nationwide Case-Control Study)': The American Journal of Cardiology 2019 Nov 15;124(10):1590-1593./ doi: 10.1016/***.2019.08.010

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The American journal of cardiology 2021年 142卷 161页

作者： Shiu-Dong Chung Ju-Chi Liu Tsai-Ning Lou Ben-Chang Shia Herng-Ching Lin Li-Ting Kao Division of Urology Department of Surgery Far Eastern Memorial Hospital Taipei Taiwan Department of Computer Science and Engineering and Graduate Program in Biomedical Informatics College of Informatics Yuan-Ze University Chung-Li Taiwan Sleep Research Center Taipei Medical University Hospital Taipei Taiwan. Department of Internal Medicine School of Medicine College of Medicine Taipei Medical University Taipei Taiwan Division of Cardiovascular Medicine Department of Medicine Medical University Hospital-Shuang Ho Hospital TaipeiTaiwan. School of Health Care Administration Taipei Medical University Taipei Taiwan. Big Data Research Center Taipei Medical University Taipei Taiwan. Sleep Research Center Taipei Medical University Hospital Taipei Taiwan School of Health Care Administration Taipei Medical University Taipei Taiwan Graduate Institute of Life Sciences National Defense Medical Center Taipei Taiwan Department of Pharmacy Practice Tri-Service General Hospital Taipei Taiwan School of Pharmacy National Defense Medical Center Taipei Taiwan.. Electronic address: kaoliting@***.

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Author Correction: Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries

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Nature genetics 2023年第3期55卷 519-520页

作者： Ceres Fernandez-Rozadilla Maria Timofeeva Zhishan Chen Philip Law Minta Thomas Stephanie Schmit Virginia Díez-Obrero Li Hsu Juan Fernandez-Tajes Claire Palles Kitty Sherwood Sarah Briggs Victoria Svinti Kevin Donnelly Susan Farrington James Blackmur Peter Vaughan-Shaw Xiao-Ou Shu Jirong Long Qiuyin Cai Xingyi Guo Yingchang Lu Peter Broderick James Studd Jeroen Huyghe Tabitha Harrison David Conti Christopher Dampier Mathew Devall Fredrick Schumacher Marilena Melas Gad Rennert Mireia Obón-Santacana Vicente Martín-Sánchez Ferran Moratalla-Navarro Jae Hwan Oh Jeongseon Kim Sun Ha Jee Keum Ji Jung Sun-Seog Kweon Min-Ho Shin Aesun Shin Yoon-Ok Ahn Dong-Hyun Kim Isao Oze Wanqing Wen Keitaro Matsuo Koichi Matsuda Chizu Tanikawa Zefang Ren Yu-Tang Gao Wei-Hua Jia John Hopper Mark Jenkins Aung Ko Win Rish Pai Jane Figueiredo Robert Haile Steven Gallinger Michael Woods Polly Newcomb David Duggan Jeremy Cheadle Richard Kaplan Timothy Maughan Rachel Kerr David Kerr Iva Kirac Jan Böhm Lukka-Pekka Mecklin Pekka Jousilahti Paul Knekt Lauri Aaltonen Harri Rissanen Eero Pukkala Johan Eriksson Tatiana Cajuso Ulrika Hänninen Johanna Kondelin Kimmo Palin Tomas Tanskanen Laura Renkonen-Sinisalo Brent Zanke Satu Männistö Demetrius Albanes Stephanie Weinstein Edward Ruiz-Narvaez Julie Palmer Daniel Buchanan Elizabeth Platz Kala Visvanathan Cornelia Ulrich Erin Siegel Stefanie Brezina Andrea Gsur Peter Campbell Jenny Chang-Claude Michael Hoffmeister Hermann Brenner Martha Slattery John Potter Konstantinos Tsilidis Matthias Schulze Marc Gunter Neil Murphy Antoni Castells Sergi Castellví-Bel Leticia Moreira Volker Arndt Anna Shcherbina Mariana Stern Bens Pardamean Timothy Bishop Graham Giles Melissa Southey Gregory Idos Kevin McDonnell Zomoroda Abu-Ful Joel Greenson Katerina Shulman Flavio Lejbkowicz Kenneth Offit Yu-Ru Su Robert Steinfelder Temitope Keku Bethany van Guelpen Thomas Hudson Heather Hampel Rachel Pearlman Sonja Berndt Richard Hayes Marie Elena Martinez Sushma Thomas Douglas Corley Paul Pharoah Susanna Larsson Yun Yen Heinz-Jo Edinburgh Cancer Research Centre Institute of Genomics and Cancer University of Edinburgh Edinburgh UK. Genomic Medicine Group Instituto de Investigacion Sanitaria de Santiago Santiago de Compostela Spain. Colon Cancer Genetics Group Medical Research Council Human Genetics Unit Institute of Genetics and Cancer University of Edinburgh Edinburgh UK. Danish Institute for Advanced Study Department of Public Health University of Southern Denmark Odense Denmark. Division of Epidemiology Department of Medicine Vanderbilt-Ingram Cancer Center Vanderbilt Epidemiology Center Vanderbilt University Medical Center Nashville TN USA. Division of Genetics and Epidemiology Institute of Cancer Research London UK. Public Health Sciences Division Fred Hutchinson Cancer Research Center Seattle WA USA. Genomic Medicine Institute Cleveland Clinic Cleveland OH USA. Population and Cancer Prevention Program Case Comprehensive Cancer Center Cleveland OH USA. Colorectal Cancer Group ONCOBELL Program Bellvitge Biomedical Research Institute Barcelona Spain. Oncology Data Analytics Program Catalan Institute of Oncology Barcelona Spain. Consortium for Biomedical Research in Epidemiology and Public Health Madrid Madrid Spain. Department of Clinical Sciences Faculty of Medicine University of Barcelona Barcelona Spain. Department of Biostatistics School of Public Health University of Washington Seattle WA USA. Institute of Cancer and Genomic Sciences College of Medical and Dental Sciences University of Birmingham Birmingham UK. Department of Public Health Richard Doll Building University of Oxford Oxford UK. Department of Biomedical Informatics Vanderbilt University School of Medicine Nashville TN USA. Department of Preventive Medicine USC Norris Comprehensive Cancer Center Keck School of Medicine University of Southern California Los Angeles CA USA. Center for Public Health Genomics Department of Public Health Sciences University of Virginia Charlottesville VA USA. De

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Publisher Correction: Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

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Nature genetics 2019年第7期51卷 1192-1193页

作者： Rainer Malik Ganesh Chauhan Matthew Traylor Muralidharan Sargurupremraj Yukinori Okada Aniket Mishra Loes Rutten-Jacobs Anne-Katrin Giese Sander W van der Laan Solveig Gretarsdottir Christopher D Anderson Michael Chong Hieab H H Adams Tetsuro Ago Peter Almgren Philippe Amouyel Hakan Ay Traci M Bartz Oscar R Benavente Steve Bevan Giorgio B Boncoraglio Robert D Brown Adam S Butterworth Caty Carrera Cara L Carty Daniel I Chasman Wei-Min Chen John W Cole Adolfo Correa Ioana Cotlarciuc Carlos Cruchaga John Danesh Paul I W de Bakker Anita L DeStefano Marcel den Hoed Qing Duan Stefan T Engelter Guido J Falcone Rebecca F Gottesman Raji P Grewal Vilmundur Gudnason Stefan Gustafsson Jeffrey Haessler Tamara B Harris Ahamad Hassan Aki S Havulinna Susan R Heckbert Elizabeth G Holliday George Howard Fang-Chi Hsu Hyacinth I Hyacinth M Arfan Ikram Erik Ingelsson Marguerite R Irvin Xueqiu Jian Jordi Jiménez-Conde Julie A Johnson J Wouter Jukema Masahiro Kanai Keith L Keene Brett M Kissela Dawn O Kleindorfer Charles Kooperberg Michiaki Kubo Leslie A Lange Carl D Langefeld Claudia Langenberg Lenore J Launer Jin-Moo Lee Robin Lemmens Didier Leys Cathryn M Lewis Wei-Yu Lin Arne G Lindgren Erik Lorentzen Patrik K Magnusson Jane Maguire Ani Manichaikul Patrick F McArdle James F Meschia Braxton D Mitchell Thomas H Mosley Michael A Nalls Toshiharu Ninomiya Martin J O'Donnell Bruce M Psaty Sara L Pulit Kristiina Rannikmäe Alexander P Reiner Kathryn M Rexrode Kenneth Rice Stephen S Rich Paul M Ridker Natalia S Rost Peter M Rothwell Jerome I Rotter Tatjana Rundek Ralph L Sacco Saori Sakaue Michele M Sale Veikko Salomaa Bishwa R Sapkota Reinhold Schmidt Carsten O Schmidt Ulf Schminke Pankaj Sharma Agnieszka Slowik Cathie L M Sudlow Christian Tanislav Turgut Tatlisumak Kent D Taylor Vincent N S Thijs Gudmar Thorleifsson Unnur Thorsteinsdottir Steffen Tiedt Stella Trompet Christophe Tzourio Cornelia M van Duijn Matthew Walters Nicholas J Wareham Sylvia Wassertheil-Smoller James G Wilson Kerri L Wiggins Qiong Yang Salim Yusuf Joshua C Bis Tomi Institute for Stroke and Dementia Research (ISD) University Hospital LMU Munich Munich Germany. Centre for Brain Research Indian Institute of Science Bangalore India. INSERM U1219 Bordeaux Population Health Research Center University of Bordeaux Bordeaux France. Stroke Research Group Division of Clinical Neurosciences University of Cambridge Cambridge UK. Department of Neurology Institute for Neurodegenerative Disease Bordeaux University Hospital Bordeaux France. Laboratory for Statistical Analysis RIKEN Center for Integrative Medical Sciences Yokohama Japan. Department of Statistical Genetics Osaka University Graduate School of Medicine Osaka Japan. Laboratory of Statistical Immunology Immunology Frontier Research Center (WPI-IFReC) Osaka University Suita Japan. Department of Neurology Massachusetts General Hospital (MGH) Harvard Medical School Boston MA USA. Laboratory of Experimental Cardiology Department of Cardiology Division of Heart and Lungs University Medical Center Utrecht University of Utrecht Utrecht the Netherlands. deCODE genetics/AMGEN Inc. Reykjavik Iceland. Center for Genomic Medicine MGH Boston MA USA. J. Philip Kistler Stroke Research Center Department of Neurology MGH Boston MA USA. Program in Medical and Population Genetics Broad Institute Cambridge MA USA. Population Health Research Institute McMaster University Hamilton Ontario Canada. Department of Epidemiology Erasmus University Medical Center Rotterdam the Netherlands. Department of Radiology and Nuclear Medicine Erasmus University Medical Center Rotterdam the Netherlands. Department of Medicine and Clinical Science Graduate School of Medical Sciences Kyushu University Fukuoka Japan. Department of Clinical Sciences Lund University Malmö Sweden. INSERM Institut Pasteur de Lille LabEx DISTALZ-UMR1167 Risk Factors and Molecular Determinants of Aging-Related Diseases Université Lille Lille France. Centre Hospitalier Université Lille Epidemiology and Public Health D

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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RUDDER ROLL STABILIZATION FOR COAST GUARD CUTTERS AND FRIGATES

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NAVAL ENGINEERS JOURNAL 1983年第3期95卷 267-282页

作者： BAITIS, E WOOLAVER, DA BECK, TA Dr. Erich Baitis: a native of Germany came to the David W. Taylor Naval Ship Research and Development Center in 1957 as a co-operative student/trainee and received his Bachelor of Science Degree in Physics from Virginia Polytechnic Institute. As a 32-year-old naval architect in 1971 he received both the VietnamHonorServiceMedaland the Navy'sMeritoriousCivilianServiceAwardfor his eight months as liaison with the Vietnamese NAVVS ferro-cement ship program. As head of the Seakeeping and Stabilization Group of the Surface Ship Dynamics Branch his work has led to the development of a new standard Ship Motion Computer Program and the application of ship motions to ship habitability operability and survivability problems. A major area of this work has been the ship/aircraft interface which is particularly sensitive to ship motions wind and other environmental factors. Mr. Dennis A. Woolaver:has been employed as a Naval Architect at the David W. Taylor Naval Ship Research and Development Center since 1965 where his work has resulted in numerous patents. He received his Bachelor of Science Degree in Electrical Engineering from George Washington University where he also completed graduate work in Communication Theory. Additional fields of study include Computer Science and Personnel Management. Current efforts are directed toward surface ship motion mitigation data acquisition and statistical analysis. He is a member of the Society of Naval Architects and Marine Engineers. Lt. Tom A. Beck USCG: joined the UnitedStatesCoastGuardin 1966 where he trained as an Electronics Technician. He received a Bachelor of Science Degree in Electrical Engineering from Columbia University in 1978. From 1978 to 1979 he was an Electronics Project Officer at the CoastGuardElectronics Laboratory in Alexandria Virginia. Since 1980 he has been a Research and Development Project Officer in the Sensor Technology Branch of the CoastGuardsOffice of Research and Development. Lt. Beck is a member of the Institute of Electronic and Elect

The potential use of rudders as anti-roll devices has long been recognized. However, the possible interference of this secondary function of the rudder with its primary role as the steering mechanism has prevented, for many years, the development of practical rudder roll stabilizers. The practical feasibility of rudder roll stabilization has, however, in recent years been demonstrated by two systems designed and developed for operational evaluation aboard two different U.S. C oast G uard Cutters, i.e., Jarvis and Mellon of the 3,000-ton, 378-foot HAMILTON Class. The authors describe the major components of the rudder roll stabilization (RRS) system, along with the design goals and methodology as applied to these first two prototypes. In addition, a brief history of the hardware development is provided in order to show some of the lessons learned. The near flawless performance of the prototypes over the past four years of operational use in the North Pacific is documented. Results from various sea trials and reports of the ship operators are cited and discussed. The paper concludes with a discussion of the costs and benefits of roll stabilization achieved using both a modern anti-roll fin system, as well as two different performance level RRS systems. The benefits of roll stabilization are demonstrated by the relative expansion in the operational envelopes of the USS OLIVER HAZARD PERRY (FFG-7) Class. The varying levels of roll stabilization suggest that the merits of fins and RRS systems are strongly dependent on mission requirements and the environment. The demonstrated performance of the reliable RRS system offers the naval ship acquisition manager a good economical stabilization system.

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Fermi LAT search for dark matter in gamma-ray lines and the inclusive photon spectrum

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Physical Review D 2012年第2期86卷 022002-022002页

作者： M. Ackermann M. Ajello A. Albert L. Baldini G. Barbiellini K. Bechtol R. Bellazzini B. Berenji R. D. Blandford E. D. Bloom E. Bonamente A. W. Borgland M. Brigida R. Buehler S. Buson G. A. Caliandro R. A. Cameron P. A. Caraveo J. M. Casandjian C. Cecchi E. Charles A. Chekhtman J. Chiang S. Ciprini R. Claus J. Cohen-Tanugi J. Conrad F. D’Ammando F. de Palma C. D. Dermer E. do Couto e Silva P. S. Drell A. Drlica-Wagner Y. Edmonds R. Essig C. Favuzzi S. J. Fegan W. B. Focke Y. Fukazawa S. Funk P. Fusco F. Gargano D. Gasparrini S. Germani N. Giglietto F. Giordano M. Giroletti T. Glanzman G. Godfrey I. A. Grenier S. Guiriec M. Gustafsson D. Hadasch M. Hayashida D. Horan R. E. Hughes T. Kamae J. Knödlseder M. Kuss J. Lande A. M. Lionetto M. Llena Garde F. Longo F. Loparco M. N. Lovellette P. Lubrano M. N. Mazziotta P. F. Michelson W. Mitthumsiri T. Mizuno A. A. Moiseev C. Monte M. E. Monzani A. Morselli I. V. Moskalenko S. Murgia M. Naumann-Godo J. P. Norris E. Nuss T. Ohsugi A. Okumura E. Orlando J. F. Ormes D. Paneque J. H. Panetta M. Pesce-Rollins F. Piron G. Pivato T. A. Porter D. Prokhorov S. Rainò R. Rando M. Razzano O. Reimer M. Roth C. Sbarra J. D. Scargle C. Sgrò E. J. Siskind A. Snyder P. Spinelli D. J. Suson H. Takahashi T. Tanaka J. G. Thayer J. B. Thayer L. Tibaldo M. Tinivella D. F. Torres G. Tosti E. Troja J. Vandenbroucke V. Vasileiou G. Vianello V. Vitale A. P. Waite B. L. Winer K. S. Wood Z. Yang S. Zimmer Deutsches Elektronen Synchrotron DESY D-15738 Zeuthen Germany W. W. Hansen Experimental Physics Laboratory Kavli Institute for Particle Astrophysics and Cosmology Department of Physics and SLAC National Accelerator Laboratory Stanford University Stanford California 94305 USA Department of Physics Center for Cosmology and Astro-Particle Physics The Ohio State University Columbus Ohio 43210 USA Istituto Nazionale di Fisica Nucleare Sezione di Pisa I-56127 Pisa Italy Istituto Nazionale di Fisica Nucleare Sezione di Trieste I-34127 Trieste Italy Dipartimento di Fisica Università di Trieste I-34127 Trieste Italy Istituto Nazionale di Fisica Nucleare Sezione di Perugia I-06123 Perugia Italy Dipartimento di Fisica Università degli Studi di Perugia I-06123 Perugia Italy Dipartimento di Fisica “M. Merlin” dell’Università e del Politecnico di Bari I-70126 Bari Italy Istituto Nazionale di Fisica Nucleare Sezione di Bari 70126 Bari Italy Istituto Nazionale di Fisica Nucleare Sezione di Padova I-35131 Padova Italy Dipartimento di Fisica “G. Galilei” Università di Padova I-35131 Padova Italy Institut de Ciències de l’Espai (IEEE-CSIC) Campus UAB 08193 Barcelona Spain INAF-Istituto di Astrofisica Spaziale e Fisica Cosmica I-20133 Milano Italy Laboratoire AIM CEA-IRFU/CNRS/Université Paris Diderot Service d’Astrophysique CEA Saclay 91191 Gif sur Yvette France Artep Inc. 2922 Excelsior Springs Court Ellicott City Maryland 21042 USAresident at Naval Research Laboratory Washington D.C. 20375 USA ASI Science Data Center I-00044 Frascati (Roma) Italy Laboratoire Univers et Particules de Montpellier Université Montpellier 2 CNRS/IN2P3 Montpellier France Department of Physics Stockholm University AlbaNova SE-106 91 Stockholm Sweden The Oskar Klein Centre for Cosmoparticle Physics AlbaNova SE-106 91 Stockholm Sweden IASF Palermo 90146 Palermo Italy INAF-Istituto di Astrofisica Spaziale e Fisica Cosmica I-00133 Roma Italy Space Science Division Naval Research Labor

Dark matter particle annihilation or decay can produce monochromatic gamma-ray lines and contribute to the diffuse gamma-ray background. Flux upper limits are presented for gamma-ray spectral lines from 7 to 200 GeV and for the diffuse gamma-ray background from 4.8 GeV to 264 GeV obtained from two years of Fermi Large Area Telescope data integrated over most of the sky. We give cross-section upper limits and decay lifetime lower limits for dark matter models that produce gamma-ray lines or contribute to the diffuse spectrum, including models proposed as explanations of the PAMELA and Fermi cosmic-ray data.

关键词： FERMI surfaces DARK matter (Astronomy) ANNIHILATION reactions RADIOACTIVE decay GAMMA ray spectrometry CROSS sections (Nuclear physics)

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