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A Study on Optimization and Augmentation Techniques for Improving the Performance of CADx System for Cat Skin Disease

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Transactions of the Korean Institute of Electrical Engineers 2025年第1期74卷 135-141页

作者： Won, Hyeong-Sik Park, Jae-Beom Cho, Hyun-Chong Dept. of Electronics Engineering Interdisciplinary Graduate Program for BIT Medical Convergence Dept. of Data Science Kangwon National University Korea Republic of Dept. of Interdisciplinary Graduate Program for BIT Medical Convergence Kangwon National University Korea Republic of

In modern society, the number of households raising pets is increasing. As pet ownership increases, the cost of treating companion cats is also rising, with a significant portion of these costs going toward the treatment of skin diseases. Skin diseases are among the common ailments in pets, and swift action is required if they occur in cats. However, early lesions lack distinctive characteristics, making accurate diagnosis difficult. Therefore, this study proposes a CADx(Computer-Aided Diagnosis) system that classifies images of cat skin conditions into inflammatory lesions, non-inflammatory lesions, and normal images using a dataset of cat skin diseases. We selected the ConvNeXt model, based on CNN, which can learn regional information and features. To learn various patterns of skin lesions, we applied Mixup, an image augmentation technique. When Mixup was applied, the model accuracy was 0.8679, showing a 3.35% improvement compared to the original dataset. Additionally, Lookahead Optimizer was applied to ensure stable learning of Mixup. When both Mixup and Lookahead Optimizer were applied, the model accuracy was 0.8741, showing a high improvement of 3.97% compared to the original dataset. Therefore, the Lookahead Optimizer helps with the stable training of mixup, which can improve the performance of the model. Copyright © The Korean Institute of Electrical Engineers.

关键词： Dermatology

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Development of a Deep Learning-Based System for Cat Skin Disease Classification and Grad-CAM Visualization

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Transactions of the Korean Institute of Electrical Engineers 2025年第2期74卷 339-344页

作者： Won, Hyeong-Sik Cho, Hyun-Chong Dept. of Interdisciplinary Graduate Program for BIT Medical Convergence Kangwon National University Korea Republic of Dept. of Electronics Engineering and Interdisciplinary Graduate Program for BIT Medical Convergence Dept. of Data Science Kangwon National University Korea Republic of

Skin diseases in companion cats can worsen if not treated promptly, and this can increase the financial burden on pet owners. To prevent this, early and accurate diagnosis is essential. This study introduces a deep learning-based Computer-Aided Diagnosis (CADx) system designed to classify cat skin diseases into non-inflammatory and inflammatory lesions by comparing them with normal images. The system employs the EfficientNetV2 model and incorporates image augmentation techniques like AutoAugment and AugMix to enhance classification performance. The study results indicate that the developed model achieved an 84.68% accuracy for non-inflammatory lesions, reflecting a 10.06% improvement, and a 97.19% accuracy for inflammatory lesions, reflecting a 2.45% improvement. Furthermore, we applied Grad-CAM to visualize the regions of interest in the images, offering veterinarians critical insights into the location and characteristics of the lesions. This system has the potential to significantly improve the precision of diagnosing skin diseases in companion cats, thereby supporting better veterinary care. Copyright © The Korean Institute of Electrical Engineers.

关键词： Veterinary medicine

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Development of a Deep Learning-Based Model for Canine Skin Disease Diagnosis Using RandAugment and Patterned-GridMask

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Transactions of the Korean Institute of Electrical Engineers 2025年第1期74卷 142-148页

作者： Kim, Min-Jun Park, Jae-Beom Cho, Hyun-Chong Dept. of Electronics Engineering Interdisciplinary Graduate Program for BIT Medical Convergence Dept. of Data Science Kangwon National University Korea Republic of Dept. of Interdisciplinary Graduate Program for BIT Medical Convergence Kangwon National University Korea Republic of

In contemporary society, pets are increasingly regarded as integral family members, contributing significantly to human quality of life. The growing prevalence of dog ownership has concurrently escalated the economic burden associated with veterinary care, particularly in managing common conditions like skin diseases. This study introduces an advanced deep learning-based diagnostic system for canine skin diseases, designed for practical application in home environments. We employed RandAugment to enhance data augmentation, thereby increasing the diversity of the training dataset. Furthermore, the implementation of Patterned-GridMask significantly improved the model's generalization capabilities. The use of the AdamW optimization algorithm was instrumental in mitigating overfitting, thus enhancing the model's overall learning efficiency. The proposed Transformer-based model, ViT/B-16, achieved an accuracy of 78.65% with the original dataset. With the integration of RandAugment and Patterned-GridMask techniques, the model's accuracy improved to 84.33%, underscoring its potential effectiveness for practical veterinary applications. Copyright © The Korean Institute of Electrical Engineers.

关键词： medical imaging

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Overcoming the Blood-Brain Tumor Barrier with Docetaxel-Loaded Mesoporous Silica Nanoparticles for Treatment of Temozolomide-Resistant Glioblastoma

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ACS Applied Materials and Interfaces 2024年第17期16卷 21722-21735页

作者： Hsu, Tsung-I Chen, Yi-Ping Zhang, Rong-Lin Chen, Zih-An Wu, Cheng-Hsun Chang, Wen-Chang Mou, Chung-Yuan Chan, Hardy Wai-Hong Wu, Si-Han Ph.D. Program in Medical Neuroscience College of Medical Science and Technology Taipei Medical University and National Health Research Institutes Taipei110 Taiwan International Master Program in Medical Neuroscience College of Medical Science and Technology Taipei Medical University Taipei110 Taiwan Graduate Institute of Nanomedicine and Medical Engineering Taipei Medical University Taipei110 Taiwan International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei110 Taiwan Nano Targeting & Therapy Biopharma Inc. Taipei110 Taiwan Graduate Institute of Medical Sciences College of Medicine Taipei Medical University Taipei110 Taiwan Department of Chemistry National Taiwan University Taipei106 Taiwan

While temozolomide (TMZ) has been a cornerstone in the treatment of newly diagnosed glioblastoma (GBM), a significant challenge has been the emergence of resistance to TMZ, which compromises its clinical benefits. Additionally, the nonspecificity of TMZ can lead to detrimental side effects. Although TMZ is capable of penetrating the blood-brain barrier (BBB), our research addresses the need for targeted therapy to circumvent resistance mechanisms and reduce off-target effects. This study introduces the use of PEGylated mesoporous silica nanoparticles (MSN) with octyl group modifications (C8-MSN) as a nanocarrier system for the delivery of docetaxel (DTX), providing a novel approach for treating TMZ-resistant GBM. Our findings reveal that C8-MSN is biocompatible in vitro, and DTX@C8-MSN shows no hemolytic activity at therapeutic concentrations, maintaining efficacy against GBM cells. Crucially, in vivo imaging demonstrates preferential accumulation of C8-MSN within the tumor region, suggesting enhanced permeability across the blood-brain tumor barrier (BBTB). When administered to orthotopic glioma mouse models, DTX@C8-MSN notably prolongs survival by over 50%, significantly reduces tumor volume, and decreases side effects compared to free DTX, indicating a targeted and effective approach to treatment. The apoptotic pathways activated by DTX@C8-MSN, evidenced by the increased levels of cleaved caspase-3 and PARP, point to a potent therapeutic mechanism. Collectively, the results advocate DTX@C8-MSN as a promising candidate for targeted therapy in TMZ-resistant GBM, optimizing drug delivery and bioavailability to overcome current therapeutic limitations. © 2024 The Authors. Published by American Chemical Society.

关键词： Tumors

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Electricity Consumption Prediction using Generative Models

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Transactions of the Korean Institute of Electrical Engineers 2022年第1期71卷 218-224页

作者： Kim, Heesang Im, Hyeonseung Moon, Yang-Sae Dept. of Computer Science and Engineering Interdisciplinary Graduate Program in Medical Bigdata Convergence Kangwon National University Korea Republic of Interdisciplinary Graduate Program in Medical Bigdata Convergence Kangwon National University Korea Republic of

Recently, advanced metering infrastructure (AMI) has been deployed for power demand distribution and energy saving, and correspondingly traditional watt-hour meters installed in apartments and industrial sites are also being replaced with AMIs. Accordingly, power demand prediction using AMIs will become increasingly important to save electrical energy consumption. In this paper, we develop various deep learning-based electricity consumption prediction models using simple neural networks, convolutional neural networks, recurrent neural networks, and encoder-decoder-based generative models. To build prediction models, we use average power demand data collected from various home smart meters. Experimental results show that the generative model outperforms other deep learning-based models in terms of mean squared error, and we roughly explain why the generative model is better than other models by examining the activation layer output distributions. © 2022 Korean Institute of Electrical Engineers. All rights reserved.

关键词： Watt hour meters

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Real-Time Detection of Cattle Behavior Using YOLOv9 with AutoAugment and Mixup Data Augmentation Techniques

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Transactions of the Korean Institute of Electrical Engineers 2024年第12期73卷 2326-2332页

作者： Lee, Su-Bin Park, Jae-Beom Cho, Hyun-Chong Dept. of Electronics Engineering Dept. of Data Science Kangwon National University Korea Republic of Dept. of Data Science Kangwon National University Korea Republic of Dept. of Interdisciplinary Graduate Program for BIT Medical Convergence Kangwon National University Korea Republic of

As the number of livestock farms in Korea decreases, the scale of individual farms has grown, necessitating advanced methods for efficient livestock management. Recent studies have increasingly applied computer vision and deep learning to monitor livestock behavior, health, and disease, aiming to enhance productivity and animal welfare. This study introduces a real-time cattle behavior detection system utilizing YOLOv9, a state-of-the-art object detection algorithm known for its high accuracy and efficiency. The YOLOv9-s model, optimized for real-time detection with minimal computational overhead, was employed. To further enhance detection accuracy, we incorporated AutoAugment, a data augmentation technique that automatically selects the optimal augmentation policies, and mixup, a method that improves model generalization by creating new training samples through linear interpolation of existing ones. The application of AutoAugment improved the mean Average Precision (mAP) from 0.926 to 0.941, while the addition of mixup raised the mAP to 0.947, representing a 2.1% performance increase. These results confirm the system's capability for accurate and efficient real-time detection of cattle behavior. Copyright © The Korean Institute of Electrical Engineers.

关键词： Livestock

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Harnessing novel engineered feeder cells expressing activating molecules for optimal expansion of NK cells with potent antitumor activity

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Cellular & Molecular Immunology 2022年第2期19卷 296-298页

作者： Bokyung Min Bitna Yang You-Sun Kim Gyeong Min Park HyunAh Kim Hyojin Kim Eun-Ji Kim Yu Kyeong Hwang Eui-Cheol Shin Sungyoo Cho BioMedical Science and Engineering Interdisciplinary Program KAISTDaejeonKorea Cell Therapy Research Center GC LabCellYonginKorea Laboratory of Immunology and Infectious Diseases Graduate School of Medical Science and EngineeringKAISTDaejeonKorea

Natural killer(NK)cells play an important role in the antitumor immune response as the major cytotoxic lymphocytes in the innate immune *** cells without any genetic modifications have been used for both autologous and allogeneic ***,many reports have suggested that allogeneic NK cells can reduce the recurrence of disease and improve survival through a graft-versus-leukemia effect without GVHD[1,2].

关键词： killer expressing optimal

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Chemical Constituents and Bioactive Principles from the Mexican Truffle and Fermented Products of the Derived Fungus Ustilago maydis MZ496986

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Journal of Agricultural and Food Chemistry 2023年第2期71卷 1122-1131页

作者： Wu, Ho-Cheng His, Hsiao-Yang Hsiao, George Yen, Chia-Hung Leu, Jyh-Yih Wu, Chin-Chung Chang, Szu-Hsing Huang, Shu-Jung Lee, Tzong-Huei Graduate Institute of Pharmacognosy College of Pharmacy Taipei Medical University Taipei110 Taiwan Ph.D. Program in Clinical Drug Development of Herbal Medicine College of Pharmacy Taipei Medical University Taipei110 Taiwan Institute of Fisheries Science National Taiwan University Taipei106 Taiwan Graduate Institute of Medical Sciences and Department of Pharmacology School of Medicine College of Medicine Taipei110 Taiwan Graduate Institute of Natural Products College of Pharmacy Kaohsiung Medical University Kaohsiung807 Taiwan Department of Life Science College of Science and Engineering Fu Jen Catholic University New Taipei City242 Taiwan Graduate Institute of Applied Science and Engineering College of Science and Engineering Fu-jen Catholic University New Taipei242 Taiwan

To look in-depth into the traditional Mexican truffle, this study investigated the phytochemical and pharmacological properties of field-collected corn galls and the fermentate of its pathogen Ustilago maydis MZ496986. Here, we established the chemical profiles of both materials via the gradient HPLC-UV method and successfully identified six previously unreported chemical entities, ustilagols A-F (1-6), and 17 known components. Compounds 3, 5, and 9 exhibited potent nitric oxide production inhibitory activities in murine brain microglial BV-2 cells (IC50 = 6.7 ± 0.5, 5.8 ± 0.9, and 3.9 ± 0.1 μM) without cytotoxic effects. DIMBOA (9) also attenuates lipopolysaccharide (LPS)-stimulated NF-κB activation in RAW 264.7 macrophages (IC50 = 58.1 ± 7.2 μM). Ustilagol G (7) showed potent antiplatelet aggregation in U46619-stimulated human platelets (IC50 = 16.5 ± 5.3 μM). These findings highlighted the potential of corn galls and U. maydis MZ496986 fermentate as functional foods for improving inflammation-related discomforts and vascular obstruction. © 2023 American Chemical Society.

关键词： Nitric oxide

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Unitig-centered pan-genome machine learning approach for predicting antibiotic resistance and discovering novel resistance genes in bacterial strains

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Computational and Structural Biotechnology Journal 2024年 23卷 1864-1876页

作者： Do, Duyen Thi Yang, Ming-Ren Vo, Tran Nam Son Le, Nguyen Quoc Khanh Wu, Yu-Wei Graduate Institute of Biomedical Informatics College of Medical Science and Technology Taipei Medical University Taipei Taiwan Department of Electrical Engineering National Taiwan University of Science and Technology Taipei Taiwan Department of Business Administration College of Management Lunghwa University of Science and Technology Taoyuan City Taiwan Professional Master Program in Artificial Intelligence in Medicine College of Medicine Taipei Medical University Taipei Taiwan Clinical Big Data Research Center Taipei Medical University Hospital Taipei Taiwan TMU Research Center for Digestive Medicine Taipei Medical University Taipei Taiwan

In current genomic research, the widely used methods for predicting antimicrobial resistance (AMR) often rely on prior knowledge of known AMR genes or reference genomes. However, these methods have limitations, potentially resulting in imprecise predictions owing to incomplete coverage of AMR mechanisms and genetic variations. To overcome these limitations, we propose a pan-genome-based machine learning approach to advance our understanding of AMR gene repertoires and uncover possible feature sets for precise AMR classification. By building compacted de Brujin graphs (cDBGs) from thousands of genomes and collecting the presence/absence patterns of unique sequences (unitigs) for Pseudomonas aeruginosa, we determined that using machine learning models on unitig-centered pan-genomes showed significant promise for accurately predicting the antibiotic resistance or susceptibility of microbial strains. Applying a feature-selection-based machine learning algorithm led to satisfactory predictive performance for the training dataset (with an area under the receiver operating characteristic curve (AUC) of > 0.929) and an independent validation dataset (AUC, approximately 0.77). Furthermore, the selected unitigs revealed previously unidentified resistance genes, allowing for the expansion of the resistance gene repertoire to those that have not previously been described in the literature on antibiotic resistance. These results demonstrate that our proposed unitig-based pan-genome feature set was effective in constructing machine learning predictors that could accurately identify AMR pathogens. Gene sets extracted using this approach may offer valuable insights into expanding known AMR genes and forming new hypotheses to uncover the underlying mechanisms of bacterial AMR. © 2024 The Authors

关键词： Genes

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A Performance Comparison of Commercial Speech Recognition APIs in Noisy Environments

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Transactions of the Korean Institute of Electrical Engineers 2022年第9期71卷 1266-1273页

作者： Lee, Geonhui Lee, Sanghwa Ji, Suhwan Kim, Auk Im, Hyeonseung Dept. of Computer Science and Engineering Dept. of Convergence Security Interdisciplinary Graduate Program in Medical Bigdata Convergence Kangwon National University Korea Republic of Dept. of Convergence Security Kangwon National University Korea Republic of Interdisciplinary Graduate Program in Medical Bigdata Convergence Kangwon National University Korea Republic of

This paper compares the performance of five commercial speech recognition APIs under noisy environments, namely those provided by Amazon AWS, Microsoft Azure, Google, Kakao, and Naver. To this end, we used an open dataset for development and evaluation of multi-channel noise processing technology provided in AI Hub. We tested each API's performance with respect to the speaker's gender and location and the speech content, and measured their error rate using both word error rate (WER) and character error rate (CER). Except for the AWS API, the error rate was higher when tested with female's data than male's one, and when tested with the data recorded from the side than the front. The error rate was also relatively high when the test sentences contained proper nouns such as person's names and local names, and the shorter the sentences, the higher the error rate. Moreover, the Google API outperformed all the others in terms of both WER and CER, with 53% and 18% of error rate, respectively. © 2022 Korean Institute of Electrical Engineers. All rights reserved.

关键词： Speech recognition

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