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Detection of Femtomolar Amyloid-β Peptides for Early-Stage Identification of Alzheimer’s Amyloid-β Aggregation with Functionalized Gold nanoparticles

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ACS Applied Materials and Interfaces 2024年第3期16卷 3819-3828页

作者： Chang, Yu-Jen Chien, Yi-Hsin Chang, Chieh-Chun Wang, Pei-Ning Chen, Yun-Ru Chang, Yun-Chorng Genomics Research Center Academia Sinica Taipei115 Taiwan Taiwan International Graduate Program in Interdisciplinary Neuroscience National Taiwan University and Academia Sinica Taipei115 Taiwan Research Center for Applied Sciences Academia Sinica Taipei115 Taiwan Department of Physics National Taiwan University Taipei106 Taiwan Nano Science and Technology Program Taiwan International Graduate Program Academia Sinica and National Taiwan University Taipei115 Taiwan Brain Research Center National Yang Ming Chiao Tung University Taipei112 Taiwan Division of General Neurology Department of Neurological Institute Taipei Veterans General Hospital Taipei112 Taiwan

Progressive amyloid-β (Aβ) fibrillar aggregates have long been considered as the pathogenesis of Alzheimer’s disease (AD). Biocompatible and stable cysteine-Aβ peptide-conjugated gold nanoparticles (Cys-Aβ@AuNP) are demonstrated as suitable materials for detecting subfemtomolar Aβ peptides in human plasma. Incubation with Aβ peptides causes the Cys-Aβ@AuNP to aggregate and changes its absorption spectra. The spectral change is especially apparent and noticeable when detecting subfemtomolar Aβ peptides, and the aggregates contain only two or three AuNPs. Cys-Aβ@AuNP can also be used to identify early-stage Aβ oligomerization, which is not possible using the conventional method, in which the fluorescence of thioflavin-T is measured. The ability to detect Aβ oligomerization can facilitate therapeutics for AD. In addition, the binding of Aβ peptides by Cys-Aβ@AuNP in combination with centrifugation redirects the conventional Aβ aggregation pathway and can effectively inhibit the formation of toxic Aβ oligomers or fibrils. Therefore, the proposed Cys-Aβ@AuNP can also be used to develop effective therapeutic agents to inhibit Aβ aggregation. The results obtained in this study are expected to open revolutionary ways to both detect and inhibit Aβ aggregation at an early stage. © 2024 American Chemical Society

关键词： Oligomers

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Overcoming the Blood-Brain Tumor Barrier with Docetaxel-Loaded Mesoporous Silica nanoparticles for Treatment of Temozolomide-Resistant Glioblastoma

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ACS Applied Materials and Interfaces 2024年第17期16卷 21722-21735页

作者： Hsu, Tsung-I Chen, Yi-Ping Zhang, Rong-Lin Chen, Zih-An Wu, Cheng-Hsun Chang, Wen-Chang Mou, Chung-Yuan Chan, Hardy Wai-Hong Wu, Si-Han Ph.D. Program in Medical Neuroscience College of Medical Science and Technology Taipei Medical University and National Health Research Institutes Taipei110 Taiwan International Master Program in Medical Neuroscience College of Medical Science and Technology Taipei Medical University Taipei110 Taiwan Graduate Institute of Nanomedicine and Medical Engineering Taipei Medical University Taipei110 Taiwan International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei110 Taiwan Nano Targeting & Therapy Biopharma Inc. Taipei110 Taiwan Graduate Institute of Medical Sciences College of Medicine Taipei Medical University Taipei110 Taiwan Department of Chemistry National Taiwan University Taipei106 Taiwan

While temozolomide (TMZ) has been a cornerstone in the treatment of newly diagnosed glioblastoma (GBM), a significant challenge has been the emergence of resistance to TMZ, which compromises its clinical benefits. Additionally, the nonspecificity of TMZ can lead to detrimental side effects. Although TMZ is capable of penetrating the blood-brain barrier (BBB), our research addresses the need for targeted therapy to circumvent resistance mechanisms and reduce off-target effects. This study introduces the use of PEGylated mesoporous silica nanoparticles (MSN) with octyl group modifications (C8-MSN) as a nanocarrier system for the delivery of docetaxel (DTX), providing a novel approach for treating TMZ-resistant GBM. Our findings reveal that C8-MSN is biocompatible in vitro, and DTX@C8-MSN shows no hemolytic activity at therapeutic concentrations, maintaining efficacy against GBM cells. Crucially, in vivo imaging demonstrates preferential accumulation of C8-MSN within the tumor region, suggesting enhanced permeability across the blood-brain tumor barrier (BBTB). When administered to orthotopic glioma mouse models, DTX@C8-MSN notably prolongs survival by over 50%, significantly reduces tumor volume, and decreases side effects compared to free DTX, indicating a targeted and effective approach to treatment. The apoptotic pathways activated by DTX@C8-MSN, evidenced by the increased levels of cleaved caspase-3 and PARP, point to a potent therapeutic mechanism. Collectively, the results advocate DTX@C8-MSN as a promising candidate for targeted therapy in TMZ-resistant GBM, optimizing drug delivery and bioavailability to overcome current therapeutic limitations. © 2024 The Authors. Published by American Chemical Society.

关键词： Tumors

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Cascaded-Type Band Alignment of a WBG Perovskite/NBG Perovskite For Heterostructure Solar Cells

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ACS Applied Energy Materials 2024年第8期7卷 3039-3048页

作者： Thakran, Anjali Mohapatra, Anisha Verma, Hemant Hofmann, Mario Ansari, Zeeshan Alam Hanmandlu, Chintam Lu, Chung Hsin Chu, Chih Wei Department of Physics National Taiwan University Taipei106 Taiwan Research Center for Applied Sciences Academia Sinica 128 Academia Road Section 2 Nangang Taipei11529 Taiwan Nano-Science and Technology Program Taiwan International Graduate Program Academia Sinica Taipei106 Taiwan Department of Chemical Engineering National Taiwan University Taipei106 Taiwan Department of Photonics National Yang Ming Chiao Tung University Hsinchu City30010 Taiwan College of Engineering Center for Green Technology Chang Gung University Taoyuan City333002 Taiwan

The performance of single-junction mixed-halide perovskite-based solar cells is limited by thermalization and spectral losses. With advanced device architectures, the perovskite/perovskite heterostructure, where two or more photoactive layers are stacked together, can help to minimize these losses. In this work, we conformally transfer printed a narrow-band-gap perovskite over a spin-coated wide-band-gap perovskite layer to form a perovskite/perovskite heterostructure. This heterostructure results in broader spectral coverage and the higher position of the lowest unoccupied molecular orbital (LUMO) level of MAPbBrxI3-x compared to MA0.7FA0.3Pb0.5Sn0.5I3, forming a cascaded energy level alignment between photoactive layers. Additionally, direct evidence of improved morphology has been observed with the transfer-printing technique in heterostructure formation. The bottom layer provides favorable assistance for the growth of the top perovskite near the interface with good coverage and maintains the quality of the film. Thus, the increased crystallinity and reduced grain boundaries lead to less defects. This reduction played a key role in suppressing recombination losses at the interfaces, ultimately leading to improved device performance. These inherent properties have a positive impact on the photovoltaic response of the device, resulting in broader spectral response and power conversion efficiencies (PCEs) of 14.76% in the heterostructure device. A notable improvement is achieved compared to control single-junction devices, which typically have a PCE of nearly 10% with printed-Sn and 12% with spin-Br-based devices. Moreover, the heterostructure-based device exhibits high stability, retaining almost 80% of its initial PCE value for almost 1000 h with proper encapsulation. Our technique can be utilized for designing low-temperature and solution-processed stacked layers, applicable for optoelectronic devices, including light-emitting diodes (LEDs), sensors, and transist

关键词： Perovskite

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Effect of chemical composition and microstructure on the thermal conductivity of Mg-Al-Ca alloys

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Keikinzoku/Journal of Japan Institute of Light Metals 2024年第1期74卷 9-13页

作者： Kirimoto, Yuichi Kondo, Natsuki Ito, Mizuki Tsukeda, Tadayoshi Aida, Tetsuo Tabata, Hironobu Kurihara, Hideki Suzuki, Mayumi Department of Nano and Functional Material Science Graduate School of Science and Engineering for Education University of Toyama 3190 Gofuku Toyama-shi Toyama930-8555 Japan School of Sustainable Design Materials and Engineering University of Toyama Toyama-shi Toyama Japan Program of Materials Science and Engineering Studies in Science and Engineering Graduate School of Science and Engineering University of Toyama Toyama-shi Toyama Japan Faculty of Sustainable Design Academic Assembly University of Toyama Toyama-shi Toyama Japan CHUETSU METAL WORKS CO. LTD. Nakaniikawa-gun Toyama Japan Saitama Industrial Technology Center Kawaguchi-shi Saitama Japan Department of Mechanical Systems Engineering Faculty of Engineering Toyama Prefectural University Imizu-shi Toyama Japan

In recent years, the increasing demand for electric vehicles, digital devices such as PCs and smartphones, and renewable energy storage systems has created a need for higher-performance batteries. Accordingly, the thermal conductivity of the case that houses the battery is becoming increasingly important. In this study, compositions with high thermal conductivity and good castability were investigated, focusing on Mg-Al-Ca alloys, and the relationship between the two was examined through thermal conductivity measurements and microstructural observations. As a result, the Mg-6%Al-4%Ca alloy was optimal in terms of castability and thermal conductivity. It was confirmed that a lower Al solid solution capacity and a higher purity of the matrix phase are important to improve the thermal conductivity. It is also suggested that the second phase, platelet Al2Ca, is likely to be recognized and enriched in the matrix, contributing to the improvement of thermal conductivity. The amount of Ca solid solution in the matrix was suggested to be reduced by the enrichment of Al in the matrix. The Ca solid solution in the matrix was found to be less effective in reducing thermal conductivity than the Al solid solution. © 2024 The Japan Institute of Light Metals.

关键词： Magnesium alloys

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Transferrable Alumina Membranes as High-Performance Dielectric for Flexible 2D Materials Devices

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Advanced Electronic Materials 2024年第6期10卷

作者： Borhade, Poonam Subhash Raman, Radha Yen, Zhi-Long Hsieh, Ya-Ping Hofmann, Mario Department of Physics National Taiwan University Taipei10617 Taiwan Nano Science and Technology Program Taiwan International Graduate Program Academia Sinica Taipei10617 Taiwan Institute of Atomic and Molecular Sciences Academia Sinica Taipei10617 Taiwan Department of Physics National Central University Taoyuan320317 Taiwan International Graduate Program of Molecular Science and Technology National Taiwan University Taipei10617 Taiwan

2D materials have shown great promise for novel electronic functionality. A common challenge for 2D materials-based transistors is forming a high-performance gate terminal due to the challenges of depositing a dielectric of sufficient quality and controllable thickness. Herein the van-der-Waals integration of a free-standing Al2O3 dielectric membrane is demonstrated as a facile, scalable, and powerful gate dielectric. A process is developed that permits the wet transfer of an amorphous alumina layer with a finely adjustable equivalent oxide thickness (EOT) in the single nanometer range. Electrical characterization demonstrates the high breakdown field and low leakage of the dielectric and integration into 2D materials transistors reveals a high performance. The wafer-scale uniformity of the dielectric membrane permits the formation of large-scale flexible devices that exhibit good robustness and long-term stability. © 2024 The Authors. Advanced Electronic Materials published by Wiley-VCH GmbH.

关键词： Dielectric materials

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Implementation and Evaluation of 0.6 µm CMOS Complex RCPF for Accurate Frequency Response Measurement

IEEJ Transactions on Electronics, Information and Systems

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IEEJ Transactions on Electronics, Information and Systems 2025年第1期145卷 25-37页

作者： Sato, Lina Fukagawa, Kanta Shouno, Kazuhiro Tanimoto, Hiroshi Muto, Cosy Moriyama, Seijiro Takahashi, Chikau Yoshino, Michitaka Graduate School of Science and Technology Degree Programs in Systems and Information Engineering Master’s Program in Computer Science University of Tsukuba Japan Division of Information Engineering University of Tsukuba 1-1-1 Tennoudai Ibaraki Tsukuba305-8573 Japan Kitami Institute of Technology 165 Koen-cho Hokkaido Kitami090-8507 Japan Faculty of Education Nagasaki University 1-14 Bunkyo-machi Nagasaki852-8521 Japan Anagix Corporation 3-22-27 Numama Kanagawa Zushi249-0004 Japan Takamori Corporation Japan Research Center for Micro-Nano Technology Hosei University 3-11-15 Midori-cho Koganei Tokyo184-0003 Japan

This paper describes the implementation and evaluation of an RC polyphase filter (RCPF) and circuitry for measuring its frequency characteristics. The integrated circuit is fabricated on a 0.6 µm CMOS process and its supply voltage is 5 V. The integrated circuit includes a filter under test (FUT), a four-phase square wave generator, several analog switches and differential amplifiers to amplify the high-impedance signals of the RCPF. This FUT is a third-order complex RCPF whose passband is 8 − 40 MHz. This paper describes the design of these circuits in detail. This integrated circuit can select two measurement methods by means of external control signals. The first method uses a four-phase square wave. The frequency characteristics are measured by using an on-chip four-phase square wave generator driven by an external clock generator and by a spectrum analyzer tuned to the fundamental frequency. The second method uses an external network analyzer. Furthermore, this integrated circuit is equipped with a calibration circuit to measure the frequency characteristics of the circuitry except FUT by passing through the input / output signals of the FUT. As a result, the frequency characteristics of the FUT itself can be accurately measured. The effectiveness is confirmed through evaluation of the fabricated integrated circuit. © 2025 The Institute of Electrical Engineers of Japan.

关键词： Differential amplifiers

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Enhanced fast charging capabilities in natural graphite/iron cross-linked pectin electrodes for lithium-ion batteries

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Materials Advances 2024年第17期5卷 6820-6829页

作者： Chung, Chin-Yi Chen, Wei-Ming Chen, Yan-Ruei Chen, Liang-Yu Su, Yu-Hsuan Chi, Po-Wei Wu, Phillip M. Chang-Liao, Kuei-Shu Tang, Hong-Yi Wu, Maw-Kuen Institute of Physics Academia Sinica 128 Section 2 Academia Road Taipei11529 Taiwan Nano Science and Technology Program Taiwan International Graduate Program Academia Sinica and National Tsing Hua University 128 Section 2 Academia Road Taipei11529 Taiwan Department of Engineering and System Science National Tsing Hua University 101 Section 2 Kuang-Fu Road Hsinchu300044 Taiwan College of Science National Chung Hsing University 145 Xingda Road South District Taichung402 Taiwan Department of Applied Chemistry National Chi-Nan University 1 University Road Puli Nantou545301 Taiwan

Rapid charging capabilities are required for the broader adoption of lithium-ion batteries in emerging technologies such as electric vehicles. Although commercial graphite anodes provide a high energy density, their limitations in quick charging warrant the exploration of novel materials. This study extends prior research on the use of pectin, a natural polysaccharide, as an organic binder for graphite anodes. By introducing iron into pectin, we propose a unique ion-crosslinking mechanism that causes the graphite anode to exhibit pseudocapacitive Li storage. Our findings, corroborated by 3D Bode analysis and AC impedance spectra, revealed a positive correlation between the iron ion and the pseudocapacitive vertex in the graphite reaction. Compared with conventional binders, graphite electrodes utilizing iron-doped pectin demonstrated superior initial and stable capacities, reaching 450 mA h g−1 after 100 cycles at 1C. This study highlights the synergistic effect of pectin and iron ions, offering a new avenue for high-performance, rapid-charging, and environmentally sustainable lithium-ion batteries. © 2024 RSC.

关键词： Lithium-ion batteries

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Investigation of manufacturing conditions of single roll rapidly solidified ribbon for anode materials of magnesium rechargeable batteries

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Keikinzoku/Journal of Japan Institute of Light Metals 2023年第11期73卷 537-544页

作者： Kirimoto, Yuichi Fuke, Kousuke Tsukeda, Tadayoshi Aida, Tetsuo Nemoto, Yasunori Ikeda, Minoru Tabata, Hironobu Kurihara, Hideki Suzuki, Mayumi Department of Nano and Functional Material Science Graduate School of Science and Engineering for Education University of Toyama 3190 Gofuku Toyama-shi-shiToyama Toyama930-8555 Japan Program of Materials Science and Engineering Studies in Science and Engineering Graduate School of Science and Engineering University of Toyama Toyama-shi-shiToyama Toyama Japan Faculty of Sustainable Design Academic Assembly University of Toyama Toyama-shi Toyama-shi-shiToyama Toyama Japan FLOW Science JAPAN Shizuoka Hamamatsu-shi Japan CHUETSU METAL WORKS CO. LTD Nakaniikawa-gun Toyama Japan Saitama Industrial Technology Center Saitama Kawaguchi-shi Japan Department of Mechanical Systems Engineering Faculty of Engineering Toyama Prefectural University Imizu-shi Toyama Japan

Magnesium rechargeable batteries are attracting attention as next-generation rechargeable batteries because of their resource abundance, cost, safety, and high electrical capacity per volume compared to conventional lithium-ion rechargeable batteries. Our joint research team focused not only on the electrochemically active magnesium composition of ribbon for the negative electrode materials of magnesium rechargeable batteries but also on the production process, focused on the single roll type liquid quenching and rapid solidification method, which can be produced at a lower cost. In this study, the optimal processing conditions were examined by comparing CAE analysis with ribbon actually manufactured, with the aim of further improving manufacturing conditions using the same method, such as length discontinuities, thickness, and surface properties of ribbon. We specifically various process parameters such as injection pressure and roll peripheral speed for evaluation. As a result, several linear cracks were observed on the surface of the ribbon as the peripheral speed increased and as the Gap became wider, and the surface properties tended to deteriorate. Also, It was found that the dominant factor in the length of the ribbon was the peripheral speed. As the peripheral speed increased, the length of the ribbon tended to increase. © 2023 Japan Institute of Light Metals. All rights reserved.

关键词： Surface properties

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Electron Cloaking in MoS2 for High-Performance Optoelectronics

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nano letters 2025年第23期25卷 2025 May 28页

作者： Yu-Xiang Chen Jian-Jhang Lee Ding-Rui Chen You-Chen Lin Hao-Ting Chin Xiu-Yu Huang Sheng-Kuei Chiu Chu-Chi Ting Mario Hofmann Ya-Ping Hsieh Institute of Atomic and Molecular Sciences Academia Sinica Taipei 10617 Taiwan. International Graduate Program of Molecular Science and Technology National Taiwan University Taipei 10617 Taiwan. Molecular Science and Technology Program Taiwan International Graduate Program Academia Sinica Taipei 10617 Taiwan. Department of Electronic Engineering Chung Yuan Christian University Taoyuan 320 Taiwan. Department of Physics National Taiwan University Taipei 10617 Taiwan. Nano Science and Technology Program Taiwan International Graduate Program Academia Sinica Taipei 10617 Taiwan. Department of Materials Science and Engineering Feng Chia University Taichung 407 Taiwan. Department of Materials Science National University of Tainan Tainan 70005 Taiwan. Graduate Institute of Opto-Mechatronics Department of Mechanical Engineering National Chung Cheng University Chia-Yi 62102 Taiwan.

Defects in two-dimensional (2D) materials represent both challenges and opportunities to their optoelectronic performance. While defects limit the carrier mobility in transistors through increased charge scattering, they also enhance 2D material functionality in sensors. Electron cloaking, a process that reduces Coulomb scattering via localized electron-defect interactions, has recently been shown to mitigate the performance degradation of bulk semiconductors in the presence of defects. We demonstrate the realization of electron cloaking in 2D materials through the metal decoration of defects. Sulfur vacancies were introduced in MoS and selectively decorated with aluminum using atomic layer deposition. Theoretical and experimental characterization demonstrate the suppression of electronic scattering through localized interactions. Optoelectronic measurements reveal a significant improvement in carrier mobility and lifetime, highlighting the effectiveness of the cloaking mechanism. Our findings open a route independently to maximize performance and functionality of optoelectronic devices, which is illustrated by the realization photosensors with unprecedented sensitivity and speed.

关键词： 2D material Coulomb scattering MoS2 defect-limited mobility electron cloaking electron−defect interaction vacancies

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Z-Laminating Assembly of Graphene nanoflakes for Super-Strong Membranes and Functional Coatings

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ACS Applied nano Materials 2024年第13期7卷 14957-14963页

作者： Santos, Ian Daniell Tjarks, Patrick Muthu, Jeyavelan Lin, You-Chen Yen, Zhi-Long Chand, Pradyumna Kumar Raman, Radha Nguyen, Dinh Tuan Rouhani, Mehdi Jeng, Yeau-Ren Hsieh, Ya-Ping Hofmann, Mario Department of Physics National Taiwan University Taipei 106 Taiwan Nano Science and Technology Program Taiwan International Graduate Program Academia Sinica and National Taiwan University Taipei 106 Taiwan J. Heyrovsky Institute of Physical Chemistry of the Czech Academy of Sciences Prague 18200 Czech Republic Institute of Atomic and Molecular Sciences Academia Sinica Taipei 106 Taiwan Department of Chemistry National Taiwan University Taipei 106 Taiwan Department of Physics National Central University Taoyuan 320 Taiwan Molecular Science and Technology Program Taiwan International Graduate Program Academia Sinica and National Central University Taipei 106 Taiwan Department of Biomedical Engineering National Cheng Kung University 1 University Road Tainan 70101 Taiwan Department of Materials Science and Engineering National Cheng Kung University Tainan 70101 Taiwan Academy of Innovative Semiconductor and Sustainable Manufacturing National Cheng-Kung University (NCKU) Tainan 70101 Taiwan

We demonstrate the strengthening of graphene, an atomically thin carbon allotrope, by out-of-plane folding. Through lateral confinement of graphene at the water-air interface, nanoscale buckling was induced in suspended flakes, leading to an unexpected folding transition beyond a critical surface pressure. The emergence of folding was confirmed by in situ Brewster angle reflectivity and ex situ microscopy, showing a unique “z-laminated” nanostructure. Molecular dynamics simulations indicate that z-lamination yields an enhanced adhesion between neighboring flakes compared to lateral sliding, which was confirmed by a surface pressure hysteresis during the folding process. Mechanical testing reveals superior Young’s modulus and yield strength when compared to conventional graphene assemblies and even compared to composites. We demonstrate the potential of the z-lamination approach for applications in graphene-based structural materials, tribological layers, and functional electrochemical coatings. Finally, the complete recyclability of z-laminated graphene opens up new routes toward sustainable nanostructured materials. © 2024 The Authors. Published by American Chemical Society

关键词： 2D materials composites laminated graphene membranes recyclable

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