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2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018

作者： Reis, R.F. Rocha, B.M. Santos, R. W. Dos Lobosco, M. Computer Science Department Federal University of Juiz de Fora Juiz de Fora MG36036-900 Brazil Graduate Program in Computational Modelling Federal University of Juiz de Fora Juiz de Fora MG36036-900 Brazil

ISBN: (纸本)9781538654880

In young adults, up to 20% of all cases of sudden death are due to myocarditis, a heart disease caused by inflammation in the myocardium. There are several reasons that lead to myocarditis, including infections caused by a virus, bacteria, protozoa, fungus, and others. Additionally, this inflammatory response is one of the consequences of an infection triggered by an immunological reaction, which causes an edema in the heart. One of the techniques used to visualize myocardial edema is the cardiovascular magnetic resonance of myocardial tissue. Using this imaging exam it is possible to visualize hyperintense signal in the edematous zone. This paper aims to model and simulate the mechanical deformation due to a bacterial infection in a two-dimensional domain that represents a short axis slice of the heart and compares qualitatively the results with data found from literature. This mathematical model consists of partial differential equations (PDEs) that use the Biot theory of poroelasticity applied to living tissue and coupled with an immune system dynamics to model the edema formation. Thus, the mathematical model used in this study is basically divided into two parts: one modelling the immune system response due to a bacterial infection, represented by neutrophils;and another representing the hydro-mechanical problem. The preliminary results show that our model is able to reproduce some key aspects related to an initial myocarditis. © 2018 IEEE.

关键词： Tissue

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Bayesian data assimilation to support informed decision-making in individualised chemotherapy

arXiv

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arXiv 2019年

作者： Maier, Corinna Hartung, Niklas de Wiljes, Jana Kloft, Charlotte Huisinga, Wilhelm Institute of Mathematics University of Potsdam Germany Graduate Research Training Program PharMetrX: Pharmacometrics & Computational Disease Modelling Freie Universität Berlin University of Potsdam Germany Departement of Mathematics and Statistics University of Reading Whiteknights United Kingdom Department of Clinical Pharmacy and Biochemistry Institute of Pharmacy Freie Universität Berlin Germany

An essential component of therapeutic drug/biomarker monitoring (TDM) is to combine patient data with prior knowledge for model-based predictions of therapy outcomes. Current Bayesian forecasting tools typically rely only on the most probable model parameters (maximum a-posteriori (MAP) estimate). This MAP-based approach, however, does neither necessarily predict the most probable outcome nor does it quantify the risks of treatment inefficacy or toxicity. Bayesian data assimilation (DA) methods overcome these limitations by providing a comprehensive uncertainty quantification. We compare DA methods with MAP-based approaches and show how probabilistic statements about key markers related to chemotherapy-induced neutropenia can be leveraged for more informative decision support in individualised chemotherapy. Sequential Bayesian DA proved to be most computational efficient for handling interoccasion variability and integrating TDM data. For new digital monitoring devices enabling more frequent data collection, these features will be of critical importance to improve patient care decisions in various therapeutic areas. Copyright © 2019, The Authors. All rights reserved.

关键词： Hospital data processing

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Problem-based learning methodology applied within a data network infrastructure design course a real case implementation

Problem-based learning methodology applied within a data net...

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Iberian Conference on Information Systems and Technologies (CISTI)

作者： Valéria Farinazzo Martins Paulo N. M. Sampaio Antônio José A. Cordeiro Bruno Ferreira Viana Mackenzie Prebisterian University Computing and Systems Graduate Program Salvador University (UNIFACS) Computational Modelling and Industrial Technology Senai - Cimatec Management and Technology Graduate Professional Program (GESTEC) Bahia State Estácio University (Estácio FIB)

Education professionals are always searching for new ways of promoting learning, either by modifying the pedagogical project of courses or by the adoption of new learning strategies. In particular, this paper presents the results of an effort in order to bridge the knowledge acquired by students within classroom in face-to-face classes with technical skills required in real life situations. The contribution presented in this paper is the result of an assignment applied within an undergraduate Data Network Infrastructure Design course in a Brazilian university using an adapted Problem-Based Learning methodology (PBL), as a motivational tool. This paper also presents and discusses the resulting data related to the learning assessment.

关键词： Problem-solving Education Computer networks Electronic mail Laboratories Bridges Tools

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26th Annual computational Neuroscience Meeting (CNS*2017): Part 3 Antwerp, Belgium. 15-20 July 2017 Abstracts

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BMC NEUROSCIENCE 2017年第SUPPL 1期18卷 95-176页

作者： [Anonymous] Department of Neuroscience Yale University New Haven CT 06520 USA Department Physiology & Pharmacology SUNY Downstate Brooklyn NY 11203 USA NYU School of Engineering 6 MetroTech Center Brooklyn NY 11201 USA Departament de Matemàtica Aplicada Universitat Politècnica de Catalunya Barcelona 08028 Spain Institut de Neurobiologie de la Méditerrannée (INMED) INSERM UMR901 Aix-Marseille Univ Marseille France Center of Neural Science New York University New York NY USA Aix-Marseille Univ INSERM INS Inst Neurosci Syst Marseille France Laboratoire de Physique Théorique et Modélisation CNRS UMR 8089 Université de Cergy-Pontoise 95300 Cergy-Pontoise Cedex France Department of Mathematics and Computer Science ENSAT Abdelmalek Essaadi’s University Tangier Morocco Laboratory of Natural Computation Department of Information and Electrical Engineering and Applied Mathematics University of Salerno 84084 Fisciano SA Italy Department of Medicine University of Salerno 84083 Lancusi SA Italy Dipartimento di Fisica Università degli Studi Aldo Moro Bari and INFN Sezione Di Bari Italy Data Analysis Department Ghent University Ghent Belgium Coma Science Group University of Liège Liège Belgium Cruces Hospital and Ikerbasque Research Center Bilbao Spain BIOtech Department of Industrial Engineering University of Trento and IRCS-PAT FBK 38010 Trento Italy Department of Data Analysis Ghent University Ghent 9000 Belgium The Wellcome Trust Centre for Neuroimaging University College London London WC1N 3BG UK Department of Electronic Engineering NED University of Engineering and Technology Karachi Pakistan Blue Brain Project École Polytechnique Fédérale de Lausanne Lausanne Switzerland Departement of Mathematics Swansea University Swansea Wales UK Laboratory for Topology and Neuroscience at the Brain Mind Institute École polytechnique fédérale de Lausanne Lausanne Switzerland Institute of Mathematics University of Aberdeen Aberdeen Scotland UK Department of Integrativ

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Subnational mapping of HIV incidence and mortality among individuals aged 15–49 years in sub-Saharan Africa, 2000–18: a modelling study

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The Lancet HIV 2021年第6期8卷 e363-e375页

作者： Sartorius, Benn VanderHeide, John D. Yang, Mingyou Goosmann, Erik A. Hon, Julia Haeuser, Emily Cork, Michael A. Perkins, Samantha Jahagirdar, Deepa Schaeffer, Lauren E. Serfes, Audrey L. LeGrand, Kate E. Abbastabar, Hedayat Abebo, Zeleke Hailemariam Abosetugn, Akine Eshete Abu-Gharbieh, Eman Accrombessi, Manfred Mario Kokou Adebayo, Oladimeji M. Adegbosin, Adeyinka Emmanuel Adekanmbi, Victor Adetokunboh, Olatunji O. Adeyinka, Daniel Adedayo Ahinkorah, Bright Opoku Ahmadi, Keivan Ahmed, Muktar Beshir Akalu, Yonas Akinyemi, Oluwaseun Oladapo Akinyemi, Rufus Olusola Aklilu, Addis Akunna, Chisom Joyqueenet Alahdab, Fares Al-Aly, Ziyad Alam, Noore Alamneh, Alehegn Aderaw Alanzi, Turki M. Alemu, Biresaw Wassihun Alhassan, Robert Kaba Ali, Tilahun Alipour, Vahid Amini, Saeed Ancuceanu, Robert Ansari, Fereshteh Anteneh, Zelalem Alamrew Anvari, Davood Anwer, Razique Appiah, Seth Christopher Yaw Arabloo, Jalal Asemahagn, Mulusew A. Asghari Jafarabadi, Mohammad Asmare, Wondwossen Niguse Atnafu, Desta Debalkie Atout, Maha Moh'd Wahbi Atreya, Alok Ausloos, Marcel Awedew, Atalel Fentahun Ayala Quintanilla, Beatriz Paulina Ayanore, Martin Amogre Aynalem, Yared Asmare Ayza, Muluken Altaye Azari, Samad Azene, Zelalem Nigussie Babar, Zaheer-Ud-Din Baig, Atif Amin Balakrishnan, Senthilkumar Banach, Maciej Bärnighausen, Till Winfried Basu, Sanjay Bayati, Mohsen Bedi, Neeraj Bekuma, Tariku Tesfaye Bezabhe, Woldesellassie M. Mequanint Bhagavathula, Akshaya Srikanth Bhardwaj, Pankaj Bhattacharyya, Krittika Bhutta, Zulfiqar A. Bibi, Sadia Bikbov, Boris Birhan, Tsegaye Adane Bitew, Zebenay Workneh Bockarie, Moses John Boloor, Archith Brady, Oliver J. Bragazzi, Nicola Luigi Briko, Andrey Nikolaevich Briko, Nikolay Ivanovich Burugina Nagaraja, Sharath Butt, Zahid A. Cárdenas, Rosario Carvalho, Felix Charan, Jaykaran Chatterjee, Souranshu Chattu, Soosanna Kumary Chattu, Vijay Kumar Chowdhury, Mohiuddin Ahsanul Kabir Chu, Dinh-Toi Cook, Aubrey J. Cormier, Natalie Maria Cowden, Richard G. Culquichicon, Carlos Dagnew, Baye Dahlawi, Saad M.A. D Centre for Tropical Medicine and Global Health Nuffield Department of Medicine University of Oxford Oxford United Kingdom Malaria Atlas Project University of Oxford Oxford United Kingdom The George Institute for Global Health University of Oxford Oxford United Kingdom Department of Health Metrics Sciences School of Medicine University of Washington Seattle WA United States Institute for Health Metrics and Evaluation University of Washington Seattle WA United States Department of Global Health University of Washington Seattle WA United States Department of Medicine University of Washington Seattle WA United States Insights Program Bill and Melinda Gates Foundation Seattle WA United States Global Programs Medical Teams International Seattle WA United States Department of Pediatric Newborn Medicine Brigham and Women's Hospital Boston MA United States Advanced Diagnostic and Interventional Radiology Research Center Tehran University of Medical Sciences Tehran Iran Multiple Sclerosis Research Center Tehran University of Medical Sciences Tehran Iran Department of Epidemiology and Biostatistics Tehran University of Medical Sciences Tehran Iran Pediatric Chronic Kidney Disease Research Center Tehran University of Medical Sciences Tehran Iran Department of Environmental Health Engineering Tehran University of Medical Sciences Tehran Iran Metabolomics and Genomics Research Center Tehran University of Medical Sciences Tehran Iran Research Center for Immunodeficiencies Tehran University of Medical Sciences Tehran Iran Department of Public Health Arba Minch University Arba Minch Ethiopia Department of Medical Laboratory Sciences Arba Minch University Arba Minch Ethiopia College of Medicine and Health Science Arba Minch University Arba Minch Ethiopia Department of Nursing Arba Minch University Arba Minch Ethiopia Department of Biomedical Sciences Arba Minch University Arba Minch Ethiopia Department of Public Health Debre Berhan University Debre Brehan

Background: High-resolution estimates of HIV burden across space and time provide an important tool for tracking and monitoring the progress of prevention and control efforts and assist with improving the precision and efficiency of targeting efforts. We aimed to assess HIV incidence and HIV mortality for all second-level administrative units across sub-Saharan Africa. Methods: In this modelling study, we developed a framework that used the geographically specific HIV prevalence data collected in seroprevalence surveys and antenatal care clinics to train a model that estimates HIV incidence and mortality among individuals aged 15–49 years. We used a model-based geostatistical framework to estimate HIV prevalence at the second administrative level in 44 countries in sub-Saharan Africa for 2000–18 and sought data on the number of individuals on antiretroviral therapy (ART) by second-level administrative unit. We then modified the Estimation and Projection Package (EPP) to use these HIV prevalence and treatment estimates to estimate HIV incidence and mortality by second-level administrative unit. Findings: The estimates suggest substantial variation in HIV incidence and mortality rates both between and within countries in sub-Saharan Africa, with 15 countries having a ten-times or greater difference in estimated HIV incidence between the second-level administrative units with the lowest and highest estimated incidence levels. Across all 44 countries in 2018, HIV incidence ranged from 2·8 (95% uncertainty interval 2·1–3·8) in Mauritania to 1585·9 (1369·4–1824·8) cases per 100 000 people in Lesotho and HIV mortality ranged from 0·8 (0·7–0·9) in Mauritania to 676·5 (513·6–888·0) deaths per 100 000 people in Lesotho. Variation in both incidence and mortality was substantially greater at the subnational level than at the national level and the highest estimated rates were accordingly higher. Among second-level administrative units, Guijá District, Gaza Province, Mozambique,

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A Three-Dimensional computational Model of the Innate Immune System 1

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12th International Conference on computational Science and Its Applications (ICCSA)

作者： Rocha, Pedro Augusto F. Xavier, Micael P. Pigozzo, Alexandre B. Quintela, Barbara de M. Macedo, Gilson C. dos Santos, Rodrigo Weber Lobosco, Marcelo Graduate Program in Computational Modelling UFJF Juiz de Fora MG Brazil Graduate Program in Biological Science UFJF Juiz de Fora MG Brazil

ISBN: (数字)9783642311253

ISBN: (纸本)9783642311246;9783642311253

The Human Immune System is a complex system responsible for protecting the organism against diseases. Although understanding how it works is essential to develop better treatments against diseases, its complexity makes this task extremely hard. In this work a three-dimensional mathematical and computational model of part of this system, the innate immune system, is presented. The high computational costs associated to simulations lead the development of a parallel version of the code, which has achieved a speedup of about 72 times over its sequential counterpart.

关键词： Immune system

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Dynamic output compensator design for time-varying discrete time systems with delayed states

Dynamic output compensator design for time-varying discrete ...

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作者： Leite, Valter J.S. Castelan, Eugênio B. Miranda, Márcio F. Viana, Dimitri C. CEFET-MG Campus Divinópolis Rua Monte Santo 319 35502-036 Divinópolis MG Brazil DAS-CTC/UFSC P.O. Box 476 88040-900 Florianópolis SC Brazil COLTEC UFMG Av. Antônio Carlos 6627 31270-010 Belo Horizonte MG Brazil Graduate Program on Mathematical and Computational Modelling CEFET-MG Av. Amazonas 5253 30480-000 Belo Horizonte MG Brazil

ISBN: (纸本)9781424474264

Convex conditions, proposed as a feasibility test of a set of linear matrix inequalities (LMIs), are given for the design of a partially parameter dependent dynamic output feedback controller for a class of discrete time systems with delayed state. This class concerns the systems with time-varying delay in the state and time varying parameters, both assumed to be available on line. The controller is composed by a classical part, feeding-back the system output and another one where the delayed output of the system is feedback. This last part can be avoided in case of inaccessible delay value, resulting in a more classical control design. Different from other approaches found in the literature, it is used a parameter dependent Lyapunov-Krasovskii functional candidate and a slack matrix variable to reduce the conservatism of the proposed approach. The resulting parameter dependent controller can be obtained on line as a convex combination of some 'vertex' controllers. Numerical examples are presented to illustrated the effectiveness of the proposal. © 2010 AACC.

关键词： Controllers

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Fuzzy control of delayed systems: less conservative convex conditions

Fuzzy control of delayed systems: less conservative convex c...

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American Control Conference

作者： Dimitri C. Viana Valter J. S. Leite Marcio F. Miranda Graduate Program on Mathematical and Computational Modelling (GPMCM) CEFET-MG Av. Amazonas 5253 30480-000 Belo Horizonte MG Brazil CEFET-MG/Campus Divinopolis Rua Monte Santo 319 35502-036 Divinopolis MG Brazil COLTEC/UFMG Av. Antonio Carlos 6627 31270-010 Belo Horizonte MG Brazil

ISBN: (纸本)9781424474264

Convex conditions for stability analysis and control synthesis for discrete-time fuzzy systems with delayed state are proposed in this paper. The conditions are obtained by considering a parameter dependent Lyapunov-Krasovskii functional, slack matrix variables and, in the synthesis case, an instrumental variable. In all cases, the conditions are formulated as an LMI (linear matrix inequality) feasibility test, that can be efficiently solved in polynomial time by specialized numerical solvers. It is shown that the proposed conditions encompass quadratic stability based formulations. Moreover, in the stability analysis case, conditions published recently in the literature can be recovered as a particular case from those proposed in this paper. Convex conditions for controller synthesis are proposed using an instrumental variable, yielding complementary results when compared with other conditions recently published in the literature. Numerical examples are presented to illustrate the efficiency of the proposed conditions. Comparisons are made with other conditions from the literature.

关键词： Fuzzy control Delay systems Fuzzy systems Linear matrix inequalities Stability analysis Instruments Control systems Control system synthesis Nonlinear systems Digital control

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Dynamic Output Stabilizing Design for Discrete-Time Fuzzy Systems With Time-Varying Delay

Dynamic Output Stabilizing Design for Discrete-Time Fuzzy Sy...

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2010 49th IEEE Conference on Decision and Control

作者： Dimitri C. Viana Valter J. S. Leite Eugenio B. Castelan Marcio F. Miranda Graduate Program on Mathematical and Computational Modelling (GPMCM) CEFET-MG Av. Amazonas 7576 30480-000 Belo Horizonte MG Brazil CEFET-MG / Campus Divinopolis R. Alvares Azevedo 400 35500-970 Divinopolis MG Brazil UFSC DAS-CTC Florianpolis SC 88040-900 BRAZIL COLTEC / UFMG Av. Antonio Carlos 6627 31270-010 Belo Horizonte MG Brazil

ISBN: (纸本)9781424477456

The design of a distributed-compensation (DC) output feedback controller for discrete-time fuzzy systems with time-varying delay is proposed by the formulation of convex optimization problems, formulated as a set of linear matrix inequalities (LMIs). At the exception of controller matrix D, all other are designed depending on the submodes of the fuzzy system and assembled together by fuzzy inference rules. The novelty of this proposal is that the controller is composed by a classical part, feeding-back the system output, and another where the delayed output of the system is dynamically feedback, whenever the delay is known. Different from other approaches found in the literature, it is used a parameter dependent Lyapunov-Krasovskii function candidate and extra matrices to reduce the conservatism of the proposed approach. Numerical experiments are presented showing the effectiveness of the proposal.

关键词： Fuzzy systems time varying output(systems) discrete fuzzy system discrete time systems Controllers discrete-time Conservatism Fuzzy inference rule Novelty delay

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Dynamic output compensator design for time-varying discrete time systems with delayed states

Dynamic output compensator design for time-varying discrete ...

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American Control Conference

作者： Valter J. S. Leite Eugenio B. Castelan Marcio F. Miranda Dimitri C. Viana CEFET-MG/Campus Divinopolis Rua Monte Santo 319 35502-036 Divinopolis MG Brazil DAS-CTC/UFSC P.O. Box 476 88040-900 Florianopolis SC Brazil COLTEC/UFMG Av. Antonio Carlos 6627 31270-010 Belo Horizonte MG Brazil Graduate Program on Mathematical and Computational Modelling CEFET-MG Av. Amazonas 5253 30480-000 Belo Horizonte MG Brazil

ISBN: (纸本)9781424474264

关键词： Time varying systems Discrete time systems Delay systems Delay effects Output feedback Control systems System testing Linear matrix inequalities Linear feedback control systems Control design

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