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Spatial atlas of the mouse central nervous system at molecular resolution (vol 622, pg 552, 2023)

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NATURE 2024年第7993期625卷 E6-E6页

作者： Shi, Hailing He, Yichun Zhou, Yiming Huang, Jiahao Maher, Kamal Wang, Brandon Tang, Zefang Luo, Shuchen Tan, Peng Wu, Morgan Lin, Zuwan Ren, Jingyi Thapa, Yaman Tang, Xin Chan, Ken Y. Deverman, Benjamin E. Shen, Hao Liu, Albert Liu, Jia Wang, Xiao Broad Institute of MIT and Harvard Cambridge MA USA Department of Chemistry Massachusetts Institute of Technology Cambridge MA USA John A. Paulson School of Engineering and Applied Sciences Harvard University Boston MA USA Computational and Systems Biology PhD Program Massachusetts Institute of Technology Cambridge MA USA Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology Cambridge MA USA Department of Biology Massachusetts Institute of Technology Cambridge MA USA Klarman Cell Observatory Broad Institute of MIT and Harvard Cambridge MA USA Department of Chemistry and Chemical Biology Harvard University Cambridge MA USA Stanley Center for Psychiatric Research Broad Institute of MIT and Harvard Cambridge MA USA

Ubiquitous Flat Bands in a Cr-based Kagome Superconductor

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arXiv 2024年

作者： Guo, Yucheng Wang, Zehao Xie, Fang Huang, Yuefei Gao, Bin Oh, Ji Seop Wu, Han Liu, Zhaoyu Ren, Zheng Fang, Yuan Biswas, Ananya Zhang, Yichen Yue, Ziqin Hu, Cheng Jozwiak, Chris Bostwick, Aaron Rotenberg, Eli Hashimoto, Makoto Lu, Donghui Kono, Junichiro Chu, Jiun-Haw Yakobson, Boris I. Birgeneau, Robert J. Si, Qimiao Dai, Pengcheng Yi, Ming Department of Physics and Astronomy Rice University HoustonTX77005 United States Advanced Light Source Lawrence Berkeley National Laboratory BerkeleyCA94720 United States Department of Materials Science and NanoEngineering Rice University HoustonTX77005 United States Department of Physics University of California BerkeleyCA94720 United States Department of Physics University of Washington Washington98105 United States Applied Physics Graduate Program Smalley-Curl Institute Rice University HoustonTX77005 United States Stanford Synchrotron Radiation Lightsource SLAC National Accelerator Laboratory Menlo ParkCA94025 United States Department of Electrical and Computer Engineering Rice University HoustonTX77005 United States Smalley-Curl Institute Rice University HoustonTX77005 United States Department of Materials Science and NanoEngineering Rice University HoustonTX77005 United States

In the quest for novel quantum states driven by topology and correlation, kagome lattice materials have garnered significant interest due to their distinctive electronic band structures, featuring flat bands (FBs) arising from the quantum destructive interference of the electronic wave function. The tuning of the FBs to the chemical potential would lead to the possibility of liberating electronic instabilities that lead to emergent electronic orders. Despite extensive studies, direct evidence of FBs tuned to the chemical potential and their participation in emergent electronic orders have been lacking in bulk quantum materials. Here using a combination of Angle-Resolved Photoemission Spectroscopy (ARPES) and Density Functional Theory (DFT), we reveal that the low-energy electronic structure of the recently discovered Cr-based kagome metal superconductor CsCr3Sb5 is dominated by a pervasive FB in close proximity to, and below the Fermi level. A comparative analysis with orbital-projected DFT and polarization dependence measurement uncovers that an orbital-selective renormalization mechanism is needed to reconcile the discrepancy with the DFT calculations, which predict the FB to appear 200 meV above the Fermi level. Furthermore, we observe the FB to shift away from the Fermi level by 20 meV in the low-temperature density wave-ordered phase, highlighting the role of the FB in the emergent electronic order. Our results reveal CsCr3Sb5 to stand out as a promising platform for further exploration into the effects of FBs near the Fermi level on kagome lattices, and their role in emergent orders in bulk quantum materials. © 2024, CC BY.

关键词： Density functional theory

Caco-2 Cell-Derived Biomimetic Electrochemical Biosensor for Cholera Toxin Detection

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SSRN

SSRN 2022年

作者： Kim, Yonghwan Lee, Dongtak Seo, Youngjun Jung, Hyo Gi Jang, Jae Won Park, Dongsung Kim, Insu Lee, Gyudo Hwang, Kyo Seon Kim, Seung-Hyun Lee, Sang Won Lee, Jeong Hoon Yoon, Dae Sung School of Biomedical Engineering Korea University Seoul02841 Korea Republic of Interdisciplinary Program in Precision Public Health Korea University Seoul02841 Korea Republic of Department of Clinical Pharmacology and Therapeutics College of Medicine Kyung Hee University Seoul02447 Korea Republic of Department of Biotechnology and Bioinformatics Korea University Sejong30019 Korea Republic of Interdisciplinary Graduate Program for Artificial Intelligence Smart Convergence Technology Korea University Sejong30019 Korea Republic of School of Engineering Brown University ProvidenceRI02912 United States Department of Electrical Engineering and Computer Science University of California IrvineCA92697 United States Department of Electrical Engineering Kwangwoon University Seoul01897 Korea Republic of Astrion Inc Seoul02841 Korea Republic of

Cholera is a highly contagious and lethal waterborne disease induced by an infection with Vibrio cholerae (V. cholerae) secreting cholera toxin (CTx). Cholera toxin subunit B (CTxB) from the CTx specifically binds with monosialo-tetra-hexosyl-ganglioside (GM1) found on the exterior cell membrane of an enterocyte. Owing to the pathological process of CTx, a biomimetic electrochemical biosensor (CCB) was developed by applying GM1-expressing Caco-2 cell membrane (CCM) on the electrode surface of the biosensor for CTx detection. Briefly, the electrode surface was functionalized with CCM using the vesicle fusion method. The specific binding between GM1 and CTxB on the electrode surface was verified using confocal laser scanning microscopy and atomic force microscopy. The CTxB detection performances of the CCB, including sensitivity, selectivity, and long-term stability, were determined using electrochemical impedance spectroscopy (EIS). Based on the results, the CCB had an excellent limit of detection of ~11.46 nM and a detection range spanning 100 ng/mL - 1 mg/mL. Further, the CCB had high selectivity for the CTxB compared to different interfering molecules, which are abundant constituents of intestinal fluid and fecal matter in the human body. The long-term stability of the CCBs was also verified for 3 weeks using EIS. Overall, the CCB was found to have an excellent potential for application to point-of-care and cost-effective testing for CTxB detection in developing countries. © 2022, The Authors. All rights reserved.

关键词： Electrochemical impedance spectroscopy

Transfer learning approach to modeling multichannel gate-all-around nanosheet field-effect transistors under work function fluctuations

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engineering Applications of Artificial Intelligence 2025年 148卷

作者： Dash, Sagarika Li, Yiming Parallel and Scientific Computing Laboratory National Yang-Ming Chiao Tung University 1001 Ta-Hsueh Rd. Hsinchu300093 Taiwan Electrical Engineering and Computer Science International Graduate Program National Yang-Ming Chiao Tung University 1001 Ta-Hsueh Rd. Hsinchu300093 Taiwan Institute of Communications Engineering National Yang-Ming Chiao Tung University 1001 Ta-Hsueh Rd. Hsinchu300093 Taiwan Institute of Biomedical Engineering National Yang-Ming Chiao Tung University 1001 Ta-Hsueh Rd. Hsinchu300093 Taiwan Institute of Pioneer Semiconductor Innovation National Yang-Ming Chiao Tung University 1001 Ta-Hsueh Rd. Hsinchu300093 Taiwan Institute of Artificial Intelligence Innovation National Yang-Ming Chiao Tung University 1001 Ta-Hsueh Rd. Hsinchu300093 Taiwan Department of Electronics and Electrical Engineering National Yang-Ming Chiao Tung University 1001 Ta-Hsueh Rd. Hsinchu300093 Taiwan Department of Microelectronics National Yang-Ming Chiao Tung University 1001 Ta-Hsueh Rd. Hsinchu300093 Taiwan

Deep learning (DL) has significantly advanced various industries, including semiconductors, by providing sophisticated methods for analyzing emerging device data. Transfer learning (TL), a prominent DL topology, leverages knowledge from a pre-trained model to improve the performance of a specific target task. This study aims to apply TL to predict the impact of work function fluctuation (WKF) on the variability of threshold voltage (σVTH) in gate-all-around silicon nanosheet field-effect transistors (GAA Si NS FETs). We used TL to transfer knowledge from models trained on 1-channel (1ch) GAA Si NS FETs to more complex 4-channel (4ch) counterparts. The prediction accuracy is evaluated by using the mean square error(MSE), root mean square error (RMSE), and the mean absolute error(MAE) metrics. Our TL approach achieved an error rate of less than 1%, demonstrating high accuracy in predicting WKF effects on σ VTH of 4ch GAA Si NS FETs using only 500 samples. This study presents a pioneering application of TL using a one-dimensional (1D) convolutional neural network (CNN) long short-term memory (LSTM) topology in semiconductor device technology. The results effectively address the challenge of predicting σ VTH variations in advanced GAA Si NS FETs because of WKF, which eliminates the need for extensive semiconductor device simulations. © 2025 Elsevier Ltd

关键词： Convolutional neural networks

Null space-based formation control with leader change possibility 19

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Null space-based formation control with leader change possib...

19th International Conference on Advanced Robotics, ICAR 2019

作者： Netol, Valentim Ernandes Sarcinelli-Filho, Mario Brandao, Alexandre Santos Núcleo de Especialização em Robótica Federal University of Viçosa Department of Electrical Engineering and Graduate Program on Computer Science Viçosa MG Brazil Graduate Program on Electrical Engineering Federal University of Espírito Santo Vitória - ES Brazil

ISBN: (纸本)9781728124674

This work discusses the implementation and experimentation of a control system designed to guide a multi-robot formation of one aerial and three ground robots, in a trajectory tracking task. The implementation considers three partial formations of two robots, each one associated to a virtual structure, a straight line in the 3D space with its own formation controller. Two of the partial line formations are homogeneous formations of two ground vehicles, and the third one is a heterogeneous formation, involving a ground and an aerial vehicles. All the partial formations have the same reference for position, which is one of the ground vehicles. This also allows to discuss what would happen if this ground vehicle, the reference for all the line formations, and thus for the whole formation, presents a failure, what is considered here, in connection to an escorting mission. The result is that the designed control system is effectively able to accomplish the mission, even upon a failure of the reference robot, what is validated by experimental results also discussed here. © 2019 IEEE.

关键词： Ground vehicles

Thermalization of fluorescent protein exciton-polaritons at room temperature

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arXiv 2022年

作者： Satapathy, Sitakanta Liu, Bin Deshmukh, Prathmesh Molinaro, Paul M. Dirnberger, Florian Khatoniar, Mandeep Koder, Ronald L. Menon, Vinod M. Department of Physics Center for Discovery and Innovation The City College of New York 85 St. Nicholas Terrace New YorkNY10031 United States The PhD Program in Physics The Graduate Center of the City University of New York 365 5th Ave New YorkNY10016 United States Department of Electrical Engineering and Computer Science University of Michigan Ann ArborMI48109 United States

Fluorescent proteins (FPs) have recently emerged as a serious contender for realizing ultra-low threshold room temperature exciton-polariton condensation and lasing. Our contribution investigates the thermalization of FP microcavity exciton-polaritons upon optical pumping under ambient conditions. We realize polariton cooling using a new FP molecule, called mScarlet, coupled strongly to the optical modes in a Fabry-Pérot cavity. Interestingly, at the threshold excitation energy (fluence) of ~9 nJ/pulse (15.6 mJ/cm2), we observe an effective temperature, Teff ~350 ± 35 K close to the lattice temperature indicative of strongly thermalized exciton-polaritons at equilibrium. This efficient thermalization results from the interplay of radiative pumping facilitated by the energetics of the lower polariton branch and the cavity Qfactor. Direct evidence for dramatic switching from an equilibrium state into a metastable state is observed for the organic cavity polariton device at room temperature via deviation from the Maxwell-Boltzmann statistics at k1 = 0 above the threshold. Thermalized polariton gases in organic systems at equilibrium hold substantial promise for designing room temperature polaritonic circuits, switches, and lattices for analog simulation. © 2022, CC BY-NC-SA.

关键词： Polariton

Load Manipulation by a Triangular Formation of Quadrotors

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Load Manipulation by a Triangular Formation of Quadrotors

International Conference on Unmanned Aircraft Systems (ICUAS)

作者： Valentim Ernandes Neto Alexandre Santos Brandão Mário Sarcinelli-Filho Graduate Program on Electrical Engineering Federal University of Espírito Santo Vitória ES Brazil Núcleo de Especialização em Robótica Department of Electrical Engineering and Graduate Program on Computer Science Federal University of Viçosa Viçosa MG Brazil

ISBN: (数字)9781728142784

ISBN: (纸本)9781728142791

This work discusses a trajectory tracking task accomplished by a group of three Bebop 2 quadrotors working cooperatively to transport a load. Such unmanned aerial vehicles (UAVs) are considered as a triangular formation, and the load, a triangle-shaped structure, is attached to them through massless flexible cables. The reason to use three quadrotors is the gain in terms of the payload capability and the stability of the load, since it is attached to three vehicles, staying vertically aligned with the center of mass of the triangle correspondent to the formation. A formation controller, actually a kinematic controller applied to a virtual massless robot correspondent to the center of mass of the triangle, is adopted, which generates reference velocities for the three UAVs, whose movement generates the movement and reshaping of the triangular formation. Then, individual dynamic compensators are adopted for each UAV, whose input is the reference velocity delivered by the formation controller. Finally, experimental results are discussed, which validate the proposal.

关键词： Vehicle dynamics Aerodynamics Atmospheric modeling Aircraft Robot kinematics Mathematical model

Graphene Terahertz Devices for Sensing and Communication

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arXiv 2024年

作者： Samaha, Anna-Christina Doumani, Jacques Kritzell, T. Elijah Xu, Hongjing Baydin, Andrey Ajayan, Pulickel M. Tahchi, Mario El Kono, Junichiro Laboratory of Biomaterials and Intelligent Materials Department of Physics Faculty of Sciences 2 Lebanese University P.O. Box 90656 Jdeidet Lebanon Department of Electrical and Computer Engineering Rice University 6100 Main Street HoustonTX77005 United States Applied Physics Graduate Program Smalley–Curl Institute Rice University 6100 Main Street HoustonTX77005 United States Department of Physics and Astronomy Rice University 6100 Main Street HoustonTX77005 United States Smalley–Curl Institute Rice University 6100 Main Street HoustonTX77005 United States Department of Materials Science and NanoEngineering Rice University 6100 Main Street HoustonTX77005 United States Carbon Hub Rice University 6100 Main Street HoustonTX77005 United States

Graphene-based terahertz (THz) devices have emerged as promising platforms for a variety of applications, leveraging graphene’s unique optoelectronic properties. This review explores recent advancements in utilizing graphene in THz technology, focusing on two main aspects: THz molecular sensing and THz wave modulation. In molecular sensing, the environment-sensitive THz transmission and emission properties of graphene are utilized for enabling molecular adsorption detection and biomolecular sensing. This capability holds significant potential, from the detection of pesticides to DNA at high sensitivity and selectivity. In THz wave modulation, crucial for next-generation wireless communication systems, graphene demonstrates remarkable potential in absorption modulation when gated. Novel device structures, spectroscopic systems, and metasurface architectures have enabled enhanced absorption and wave modulation. Furthermore, techniques such as spatial phase modulation and polarization manipulation have been explored. From sensing to communication, graphene-based THz devices present a wide array of opportunities for future research and development. Finally, advancements in sensing techniques not only enhance biomolecular analysis but also contribute to optimizing graphene’s properties for communication by enabling efficient modulation of electromagnetic waves. Conversely, developments in communication strategies inform and enhance sensing capabilities, establishing a mutually beneficial relationship. © 2024, CC BY.

关键词： Graphene

Development of a Selective Wet-Chemical Etchant for 3D Structuring of Silicon via Nonlinear Laser Lithography

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arXiv 2023年

作者： Borra, Mona Zolfaghari Radfar, Behrad Nasser, Hisham Çolakoğlu, Tahir Tokel, Onur Turnalı, Ahmet Demirtaş, Merve Ustunel, Hande Toffoli, Daniele Ömer İlday, F. Turan, Raşit Pavlov, Ihor Bek, Alpan ODTÜ-GÜNAM Middle East Technical University Ankara06800 Turkey Ankara06800 Turkey Department of Electronics and Nanoengineering Aalto University Tietotie 3 EspooFI-02150 Finland Department of Physics Engineering Ankara University Ankara06100 Turkey Department of Physics Bilkent University Ankara06800 Turkey UNAM National Nanotechnology Research Center Institute of Materials Science and Nanotechnology Bilkent University Ankara06800 Turkey Department of Electrical and Electronics Engineering Bilkent University Ankara06800 Turkey Department of Electrical and Computer Engineering Boston University 8 Saint Mary’s Street BostonMA02215 United States Ankara06800 Turkey Network Technologies Department TUBITAK ULAKBIM Ankara06800 Turkey Department of Chemical and Pharmaceutical Sciences Trieste University Trieste Italy IOM-CNR Istituto Officina dei Materiali Trieste34149 Italy Micro and Nanotechnology Graduate Program of Natural and Applied Sciences Middle East Technical Turkey

Recently-demonstrated high-quality three-dimensional (3D) subsurface laser processing inside crystalline silicon (c-Si) wafers opens a door to a wide range of novel applications in multidisciplinary research areas. Using this technique, a novel maskless micro-pillars with precise control on the surface reflection and coverage are successfully fabricated by etching the laser processed region of c-Si wafer. To achieve this, a particular selective wet chemical etching is developed to follow subsurface laser processing of c-Si to reveal the desired 3D structures with smooth surfaces. Here, we report the development of a novel chromium-free chemical etching recipe based on copper nitrate, which yields substantially smooth surfaces at high etch rate and selectivity on the both laser-processed Si surface and subsurface, i.e., without significant etching of the unmodified Si. Our results show that the etch rate and surface morphology are interrelated and strongly influenced by the composition of the adopted etching solution. After an extensive compositional study performed at room temperature, we identify an etchant with a selectivity of over 1600 times for laser-modified Si with respect to unmodified Si. We also support our findings using density functional theory calculations of HF and Cu adsorption energies, indicating significant diversity on the c-Si and laser-modified surfaces. Copyright © 2023, The Authors. All rights reserved.

关键词： Morphology