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The ACROBAT 2022 Challenge: Automatic Registration Of Breast Cancer Tissue

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arXiv 2023年

作者： Weitz, Philippe Valkonen, Masi Solorzano, Leslie Carr, Circe Kartasalo, Kimmo Boissin, Constance Koivukoski, Sonja Kuusela, Aino Rasic, Dusan Feng, Yanbo Pouplier, Sandra Sinius Sharma, Abhinav Eriksson, Kajsa Ledesma Robertson, Stephanie Marzahl, Christian Gatenbee, Chandler D. Anderson, Alexander R.A. Wodzinski, Marek Jurgas, Artur Marini, Niccolò Atzori, Manfredo Müller, Henning Budelmann, Daniel Weiss, Nick Heldmann, Stefan Lotz, Johannes Wolterink, Jelmer M. De Santi, Bruno Patil, Abhijeet Sethi, Amit Kondo, Satoshi Kasai, Satoshi Hirasawa, Kousuke Farrokh, Mahtab Kumar, Neeraj Greiner, Russell Latonen, Leena Laenkholm, Anne-Vibeke Hartman, Johan Ruusuvuori, Pekka Rantalainen, Mattias Department of Medical Epidemiology and Biostatistics Karolinska Insitutet Stockholm Sweden Institute of Biomedicine University of Turku Turku Finland Institute of Biomedicine University of Eastern Finland Kuopio Finland Department of Surgical Pathology Zealand University Hospital Roskilde Denmark Department of Oncology and Pathology Karolinska Institutet Stockholm Sweden Gestalt Diagnostics Spokane United States Department of Integrated Mathematical Oncology Moffitt Cancer Center Tampa United States Informatics Institute University of Applied Sciences Western Switzerland Switzerland Department of Measurement and Electronics Agh University of Kraków Poland Department of Computer Science University of Geneva Geneva Switzerland Department of Neuroscience University of Padova Italy Medical Faculty University of Geneva Switzerland Fraunhofer Institute for Digital Medicine Mevis Lübeck Germany Department of Applied Mathematics Technical Medical Centre University of Twente Enschede Netherlands Multimodality Medical Imaging Technical Medical Centre University of Twente Enschede Netherlands Department of Electrical Engineering Indian Institute of Technology Bombay India Graduate School of Engineering Muroran Institute of Technology Hokkaido Japan Faculty of Medical Technology Niigata University of Health and Welfare Niigata Japan Forxai Business Operations Konica Minolta Inc. Osaka Japan Department of Computing Science University of Alberta EdmontonAB Canada Alberta Machine Intelligence Institute Edmonton Canada MedTechLabs BioClinicum Karolinska University Hospital Stockholm Sweden Faculty of Medicine and Health Technology Tampere University Tampere Finland

The alignment of tissue between histopathological whole-slide-images (WSI) is crucial for research and clinical applications. Advances in computing, deep learning, and availability of large WSI datasets have revolutionised WSI analysis. Therefore, the current state-of-the-art in WSI registration is unclear. To address this, we conducted the ACROBAT challenge, based on the largest WSI registration dataset to date, including 4,212 WSIs from 1,152 breast cancer patients. The challenge objective was to align WSIs of tissue that was stained with routine diagnostic immunohistochemistry to its H&E-stained counterpart. We compare the performance of eight WSI registration algorithms, including an investigation of the impact of different WSI properties and clinical covariates. We find that conceptually distinct WSI registration methods can lead to highly accurate registration performances and identify covariates that impact performances across methods. These results establish the current state-of-the-art in WSI registration and guide researchers in selecting and developing methods. Copyright © 2023, The Authors. All rights reserved.

关键词： Tissue

Kramers Nodal Lines and Weyl Fermions in SmAlSi

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arXiv 2022年

作者： Zhang, Yichen Gao, Yuxiang Gao, Xue-Jian Lei, Shiming Ni, Zhuoliang Oh, Ji Seop Huang, Jianwei Yue, Ziqin Zonno, Marta Gorovikov, Sergey Hashimoto, Makoto Lu, Donghui Denlinger, Jonathan D. Birgeneau, Robert J. Kono, Junichiro Wu, Liang Law, Kam Tuen Morosan, Emilia Yi, Ming Department of Physics and Astronomy Rice University HoustonTX77005 United States Department of Physics Hong Kong University of Science and Technology Clear Water Bay Hong Kong Department of Physics and Astronomy University of Pennsylvania PhiladelphiaPA19104 United States Department of Physics University of California BerkeleyCA94720 United States Applied Physics Graduate Program Smalley-Curl Institute Rice University HoustonTX77005 United States Canadian Light Source Inc. 44 Innovation Boulevard SaskatoonSKS7N 2V3 Canada Stanford Synchrotron Radiation Lightsource SLAC National Accelerator Laboratory 2575 Sand Hill Road Menlo ParkCA94025 United States Advanced Light Source Lawrence Berekeley National Laboratory BerkeleyCA94720 United States Materials Science Division Lawrence Berekeley National Laboratory BerkeleyCA94720 United States Department of Electrical and Computer Engineering Rice University HoustonTX77005 United States Department of Materials Science and Nanoengineering Rice University HoustonTX77005 United States

Kramers nodal lines (KNLs) have recently been proposed theoretically as a special type of Weyl line degeneracy connecting time-reversal invariant momenta. KNLs are robust to spin orbit coupling and are inherent to all non-centrosymmetric achiral crystal structures, leading to unusual spin, magneto-electric, and optical properties. However, their existence in in real quantum materials has not been experimentally established. Here we gather the experimental evidence pointing at the presence of KNLs in SmAlSi, a non-centrosymmetric metal that develops incommensurate spin density wave order at low temperature. Using angle-resolved photoemission spectroscopy, density functional theory calculations, and magneto-transport methods, we provide evidence suggesting the presence of KNLs, together with observing Weyl fermions under the broken inversion symmetry in the paramagnetic phase of SmAlSi. We discuss the nesting possibilities regarding the emergent magnetic orders in SmAlSi. Our results provide a solid basis of experimental observations for exploring correlated topology in SmAlSi. © 2022, CC BY-NC-SA.

关键词： Temperature

Semi-autonomous navigation for virtual tactical simulations in the military domain 8

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Semi-autonomous navigation for virtual tactical simulations ...

8th International Conference on Simulation and Modeling Methodologies, Technologies and Applications, SIMULTECH 2018

作者： Brondani, Juliana R. Silva, Luis A. L. Rutzig, Mateus B. Pozzer, Cesar T. Nunes, Raul C. Martins, Joaõ B. De Freitas, Edison P. Graduate Program in Electrical Engineering Federal University of Rio Grande do Sul Porto Alegre RS Brazil Graduate Program in Computer Science Federal University of Santa Maria Santa Maria RS Brazil

ISBN: (纸本)9789897583230

Integrated constructive and virtual simulations are becoming popular for tactical training in the military domain. An important aspect concerning the integration of these simulation models in the construction of virtual tactical simulations is the modelling and implementation of different kinds of semi-autonomous agents. A fundamental feature of these agents is the capability of intelligently and realistically modelling task-oriented navigation activities in large virtual terrain simulation environments, while following underlying military doctrine and tactics. This paper reviews important navigation issues that emerge in such simulation systems and prominent Artificial Intelligence (AI) techniques that have been explored to solve them. From this analysis, a hybrid, semi-autonomous navigation framework is proposed aiming to fulfil the needs of virtual tactical training simulations, more specifically, in the military domain. As implemented in a system for the virtual tactical simulation of artillery battery tasks, the framework shows how to overcome the challenges of implementing realistic global and local navigation behaviours for military units and, at the same time, it shows that the semi-autonomous behaviours implemented are of primary importance to allow interaction with users for learning purposes in the simulation exercises. Copyright © 2018 by SCITEPRESS-science and Technology Publications, Lda. All rights reserved.

关键词： Navigation

Overcoming the surface paradox: Buried perovskite quantum dots in wide-bandgap perovskite thin films

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arXiv 2025年

作者： Zhang, Hao Pasha, Altaf Metcalf, Isaac Zhou, Jianlin Staunstrup, Mathias Zhu, Yunxuan Liao, Shusen Ssennyimba, Ken Chen, Jia-Shiang Reddy, Surya Prakash Thébaud, Simon Hou, Jin Shuai, Xinting Mandani, Faiz Sidhik, Siraj Jones, Matthew R. Ma, Xuedan Balakrishna, R. Geetha Susarla, Sandhya Ginger, David S. Katan, Claudine Kanatzidis, Mercouri G. Bawendi, Moungi G. Natelson, Douglas Tamarat, Philippe Lounis, Brahim Even, Jacky Mohite, Aditya D. Department of Chemical and Biomolecular Engineering Rice University HoustonTX77005 United States Applied Physics Program Smalley‐Curl Institute Rice University HoustonTX77005 United States Centre for Nano and Material Sciences Jain University Jain Global Campus Kanakapura Karnataka Bangalore562112 India Department of Materials Science and NanoEngineering Rice University HoustonTX77005 United States Université de Bordeaux LP2N Talence France Institut d’Optique CNRS LP2N Talence France Department of Physics and Astronomy Rice University HoustonTX77005 United States Center for Nanoscale Materials Argonne National Laboratory LemontIL60439 United States School for Engineering of Matter Transport and Energy Arizona State University TempeAZ85281 United States UMR 6082 CNRS INSA de Rennes Rennes35708 France Department of Chemistry Rice University HoustonTX77005 United States Department of Chemistry University of Washington Box 351700 SeattleWA98195-1700 United States UMR 6226 Rennes35000 France Department of Chemistry Northwestern University EvanstonIL United States Department of Chemistry Massachusetts Institute of Technology 77 Massachusetts Avenue CambridgeMA02139 United States Department of Electrical and Computer Engineering Rice University HoustonTX77005 United States

Colloidal perovskite quantum dots (PQDs) are an exciting platform for on-demand quantum, and classical optoelectronic and photonic devices. However, their potential success is limited by the extreme sensitivity and low stability arising from their weak intrinsic lattice bond energy and complex surface chemistry. Here we report a novel platform of buried perovskite quantum dots (b-PQDs) in a three-dimensional perovskite thin-film, fabricated using one-step, flash annealing, which overcomes surface related instabilities in colloidal perovskite dots. The b-PQDs demonstrate ultrabright and stable single-dot emission, with resolution-limited linewidths below 130 μeV, photon-antibunching (g2(0)=0.1), no blinking, suppressed spectral diffusion, and high photon count rates of 104/s, consistent with unity quantum yield. The ultrasharp linewidth resolves exciton fine-structures (dark and triplet excitons) and their dynamics under a magnetic field. Additionally, b-PQDs can be electrically driven to emit single photons with 1 meV linewidth and photon-antibunching (g2(0)=0.4). These results pave the way for on-chip, low-cost single-photon sources for next generation quantum optical communication and sensing. © 2025, CC BY.

关键词： Photons

Interplay of Purcell Effect, Stimulated Emission, and Leaky Modes in the Photoluminescence Spectra of Microsphere Cavities

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Physical Review applied 2019年第5期11卷 051001-051001页

作者： Ching-Hang Chien Shang-Hsuan Wu Trong Huynh-Buu Ngo Yia-Chung Chang Research Center for Applied Sciences Academia Sinica Taipei 115 Taiwan Nano Science and Technology Program TIGP Academia Sinica Taipei 115 Taiwan Department of Engineering and System Science National Tsing Hua University Hsinchu 300 Taiwan Department of Electrical and Computer Engineering University of Texas at Austin USA Department of Electrical and Computer Engineering University of Alberta Edmonton Alberta T6G 2V4 Canada

A theoretical model for describing the emission spectra of microsphere cavities is presented and its predictions of detailed line shapes of emission spectra associated with whispering gallery modes (WGMs) of various orders in ZnO microspheres (MSs) are verified experimentally by photoluminescence (PL) spectroscopy. The interplay of the Purcell effect, quality factor, and leaky modes in spontaneous and stimulated emission spectra related to WGMs of all orders is revealed. The key success of the theory is based on the expansion of the full Green’s function of the MS in terms of all possible resonance modes in complex frequency space, which allows incorporation of contributions from leaky modes, stimulated emission processes, and the Purcell effect. We show that the spontaneous emission spectrum calculated according to Mie theory (without the Purcell effect) is dominated by the contribution of leaky modes, while the spontaneous and stimulated emission enhanced by the Purcell effect is responsible for the main WGM resonance peaks observed experimentally. It is found that the stimulated emission peaks are doubly enhanced by their respective mode quality factor Q: one factor from the Purcell effect and the other factor from the photon number derived from the rate equation. After combining all these effects, the theory can provide a quantitative description of fine features of both TE and TM modes (including higher-order modes) observed in the PL spectra of ZnO MSs. Surprisingly, it is found that for ZnO MS with a diameter larger than 5 μm, the PL emission spectrum is dominated by higher-order modes. The quantitative understanding of the interplay of these emission mechanisms should prove useful for optimizing the performance of light-emitting devices based on microresonators.

关键词： Cavity quantum electrodynamics Lasers Light-matter interaction Optical pumping Photonics Semiconductor quantum optics Spontaneous emission Whispering gallery mode resonators

electrically driven programmable phase-change meta-switch reaching 80% efficiency

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arXiv 2021年

作者： Abdollahramezani, Sajjad Hemmatyar, Omid Taghinejad, Mohammad Taghinejad, Hossein Krasnok, Alex Eftekhar, Ali A. Teichrib, Christian Deshmukh, Sanchit El-Sayed, Mostafa Pop, Eric Wuttig, Matthias Alù, Andrea Cai, Wenshan Adibi, Ali School of Electrical and Computer Engineering Georgia Institute of Technology 778 Atlantic Drive NW AtlantaGA30332-0250 United States Photonics Initiative Advanced Science Research Center City University of New York New YorkNY10031 United States Department of Electrical Engineering Precourt Institute for Energy Stanford University StanfordCA94305 United States Laser Dynamics Laboratory School of Chemistry and Biochemistry Georgia Institute of Technology AtlantaGA30332-0400 United States George W. Woodruff School of Mechanical Engineering Georgia Institute of Technology AtlantaGA30332-0405 United States Physikalisches Institut IA RWTH Aachen Sommerfeldstrasse 14 Aachen52074 Germany Physics Program Graduate Center City University of New York New YorkNY10016 United States School of Materials Science and Engineering Georgia Institute of Technology 801 Ferst Drive NW AtlantaGA30332-0295 United States

Despite recent advances in active metaoptics, efficient wide dynamic range combined with highspeed reconfigurable solutions is still elusive. Phase-change materials (PCMs) offer a compelling platform for metasurface optical elements, owing to the large index contrast and fast yet stable phase transition properties. Here, we experimentally demonstrate an in situ electrically driven reprogrammable metasurface by harnessing the unique properties of a phase-change chalcogenide alloy, Ge2Sb2Te5 (GST), in order to realize non-volatile, reversible, multilevel, fast, and pronounced optical modulation in the near-infrared spectral range. Co-optimized through a multiphysics analysis, we integrate an efficient heterostructure resistive microheater that indirectly heats and transforms the embedded GST film without compromising the optical performance of the metasurface even after several reversible phase transitions. A hybrid plasmonic-PCM meta-switch with a record eleven-fold change in the reectance (an absolute reectance contrast reaching 80%), unprecedented quasi-continuous spectral tuning over 250 nm, and operation speed that can potentially reach a few kHz is presented. Our work represents a significant step towards the development of fully integrable dynamic metasurfaces and their potential for beamforming applications. © 2021, CC BY.

关键词： Phase change materials

TiEMPO: Open-source time-dependent end-to-end model for simulating ground-based submillimeter astronomical observations

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arXiv 2021年

作者： Huijten, Esmee Roelvink, Yannick Brackenhoff, Stefanie A. Taniguchi, Akio Bakx, Tom J.L.C. Marthi, Kaushal B. Zaalberg, Stan Baselmans, Jochem J.A. Chin, Kah Wuy Huiting, Robert Karatsu, Kenichi Laguna, Alejandro Pascual Tamura, Yoichi Takekoshi, Tatsuya Yates, Stephen J.C. van Hoven, Maarten Endo, Akira Faculty of Electrical Engineering Mathematics and Computer Science Delft University of Technology Mekelweg 4 Delft2628 CD Netherlands Kavli Institute of NanoScience Faculty of Applied Sciences Delft University of Technology Lorentzweg 1 Delft2628 CJ Netherlands Division of Particle and Astrophysical Science Graduate School of Science Nagoya University Aichi464-8602 Japan Kapteyn Astronomical Institute University of Groningen P.O. Box 800 Groningen9700 AV Netherlands SRON—Netherlands Institute for Space Research Sorbonnelaan 2 Utrecht3584 CA Netherlands National Astronomical Observatory of Japan Mitaka Tokyo181-8588 Japan Department of Astronomy School of Science University of Tokyo Bunkyo Tokyo113-0033 Japan Institute of Astronomy Graduate School of Science The University of Tokyo 2-21-1 Osawa Mitaka Tokyo181-0015 Japan SRON—Netherlands Institute for Space Research Landleven 12 Groningen9747 AD Netherlands

The next technological breakthrough in millimeter-submillimeter astronomy is 3D imaging spectrometry with wide instantaneous spectral bandwidths and wide fields of view. The total optimization of the focal-plane instrument, the telescope, the observing strategy, and the signal-processing software must enable efficient removal of foreground emission from the Earth’s atmosphere, which is time-dependent and highly nonlinear in frequency. Here we present TiEMPO: Time-dependent End-to-end Model for Post-process Optimization of the DESHIMA spectrometer. TiEMPO utilizes a dynamical model of the atmosphere and parametrized models of the astronomical source, the telescope, the instrument, and the detector. The output of TiEMPO is a timestream of sky brightness temperature and detected power, which can be analyzed by standard signal-processing software. We first compare TiEMPO simulations with an on-sky measurement by the wideband DESHIMA spectrometer, and find good agreement in the noise power spectral density and sensitivity. We then use TiEMPO to simulate the detection of the line emission spectrum of a high-redshift galaxy using the DESHIMA 2.0 spectrometer in development. The TiEMPO model is open source. Its modular and parametrized design enables users to adapt it to design and optimize the end-to-end performance of spectroscopic and photometric instruments on existing and future telescopes. Copyright © 2021, The Authors. All rights reserved.

关键词： Millimeter waves

Optimal path and illumination design for multiframe motion deblurring

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Optimal path and illumination design for multiframe motion d...

Imaging Systems and Applications, ISA 2018

作者： Dean, Sarah Phillips, Zachary Waller, Laura Recht, Ben Department of Electrical Engineering and Computer Sciences UC Berkeley Berkeley United States Graduate Group in Applied Science and Technology UC Berkeley Berkeley United States

We propose an extension of coded illumination design for motion deblurring to multiframe imaging, where a large field-of-view sample is recovered from many motion-blurred measurements captured while scanning the sampl... 详细信息

ISBN: (纸本)9781943580446

关键词： Three dimensional displays

Deep learning-based super-resolution and image transformation into structured illumination microscopy

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Deep learning-based super-resolution and image transformatio...

Microscopy Histopathology and Analytics, Microscopy 2020

作者： Wang, Hongda Rivenson, Yair Jin, Yiyin Wei, Zhensong Gao, Ronald Günaydin, Harun Bentolila, Laurent A. Kural, Comert Ozcan, Aydogan Electrical and Computer Engineering Department University of California Los AngelesCA90095 United States Bioengineering Department University of California Los AngelesCA90095 United States California NanoSystems Institute University of California Los AngelesCA90095 United States Computer Science Department University of California Los AngelesCA90095 United States Department of Chemistry and Biochemistry University of California Los AngelesCA90095 United States Department of Physics Ohio State University ColumbusOH43210 United States Biophysics Graduate Program Ohio State University ColumbusOH43210 United States Department of Surgery David Geffen School of Medicine University of California Los AngelesCA90095 United States

We demonstrate single-image super-resolution in fluorescence microscopy using a trained neural-network, matching the resolution of structured illumination microscopy (SIM). This performance is achieved without any par... 详细信息

ISBN: (纸本)9781943580743

关键词： Fluorescence microscopy