作者:
Luo, HengruiPatania, AliceKim, JisuVejdemo-Johansson, MikaelLawrence Berkeley National Laboratory
1 Cyclotron Rd BerkeleyCA94720 United States Department of Statistics
College of Arts and Sciences Ohio State University 1958 Neil Ave ColumbusOH43210 United States
Indiana University 1001 IN-45/46 E SR Bypass BloomingtonIN47408 United States DataShape Team
Inria Saclay France LMO
Université Paris-Saclay Bâtiment 307 Faculté des Sciences d'Orsay Université Paris-Saclay rue Michel Magat Orsay Île-De-France 91400 France Department of Mathematics
CUNY College of Staten Island Computer Science Programme CUNY Graduate Center 2800 Victory Boulevard 1S-215 Staten IslandNY10314 United States
MSC Codes 55N31, 62R40, 68T09Topological Data Analysis (TDA) provides novel approaches that allow us to analyze the geometrical shapes and topological structures of a dataset. As one important application, TDA can be ...
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The research in the field of ergonomics can contribute to the design process of Assistive Technologies using objective and subjective data measurements. The auxiliary crutches are assistive devices commonly used in th...
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ISBN:
(纸本)9781904670841
The research in the field of ergonomics can contribute to the design process of Assistive Technologies using objective and subjective data measurements. The auxiliary crutches are assistive devices commonly used in the process of rehabilitation after lower-extremity injuries. However, for many subjects, walking with crutches in not an easy and comfortable task, as the loads on the upper limbs are substantial and expose the users to potentially harmful long-term effects. In this way, the objective of this study was, first, to report the evaluation of the user-crutch interface by using an objective measurement of the subjects’ muscular activity and exertion perception, and to discuss how objective data measured from the subjects can contribute for the design of the interface. Eleven able-bodied subjects participated. The test protocol consisted of 3 trials of walking with crutches, each one with a different hand diameter, namely 20 mm, 32 mm and 40 mm. Surface electromyography of forearms muscles was collected, and perceived exertion was measured using the Borg’s Scale. The mean of maximum EMG values showed that the highest values activity happened in the extensor digitorum muscle using the largest handles. However, the smallest handles increase electromyography activity in the flexor digitorum superficialis muscle. Statistically significant difference was found between the smaller and the larger handle diameter. The analysis of exertion perception did not show statistical difference in any of the situations investigated. Handle diameter was shown to be a factor affecting the biomechanics of the walking with crutches. In addition, ergonomic evaluation can provide objective measurements that, ultimately, May be applied in the improvement of user-product interface.
Career planning at the organizational level must be translated into career planning at the individual employee level. Performance appraisal can be used more broadly so that it can be the main tool for companies in emp...
Career planning at the organizational level must be translated into career planning at the individual employee level. Performance appraisal can be used more broadly so that it can be the main tool for companies in employee career planning. The purpose of this study is to measure how much influence the Performance Evaluation of Career Planning from employees who have occupied managerial levels goes to the next career level. In this paper, analysis of individual employee performance is carried out using the Spider Plot model. The results of analyzing individual performance from managers in different units can explain quickly and easily the appearance of the Spider Plot diagram. So, it is expected that individual career planning can be easily mapped through performance appraisal so that it can be used in career planning.
Uncertainty quantification (UQ) is a vital step in using mathematical models and simulations to take decisions. The field of cardiac simulation has begun to explore and adopt UQ methods to characterise uncertainty in ...
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Colorectal cancer (CRC) is a leading cause of mortality worldwide. We conducted a genome-wide association study meta-analysis of 100,204 CRC cases and 154,587 controls of European and east Asian ancestry, identifying ...
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Colorectal cancer (CRC) is a leading cause of mortality worldwide. We conducted a genome-wide association study meta-analysis of 100,204 CRC cases and 154,587 controls of European and east Asian ancestry, identifying 205 independent risk associations, of which 50 were unreported. We performed integrative genomic, transcriptomic and methylomic analyses across large bowel mucosa and other tissues. Transcriptome- and methylome-wide association studies revealed an additional 53 risk associations. We identified 155 high-confidence effector genes functionally linked to CRC risk, many of which had no previously established role in CRC. These have multiple different functions and specifically indicate that variation in normal colorectal homeostasis, proliferation, cell adhesion, migration, immunity and microbial interactions determines CRC risk. Crosstissue analyses indicated that over a third of effector genes most probably act outside the colonic mucosa. Our findings provide insights into colorectal oncogenesis and highlight potential targets across tissues for new CRC treatment and chemoprevention strategies.
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