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Cortical transcriptome analysis after spinal cord injury reveals the regenerative mechanism of central nervous system in CRMP2 knock-in mice

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Neural Regeneration Research 2021年第7期16卷 1258-1265页

作者： Ayaka Sugeno Wenhui Piao Miki Yamazaki Kiyofumi Takahashi Koji Arikawa Hiroko Matsunaga Masahito Hosokawa Daisuke Tominaga Yoshio Goshima Haruko Takeyama Toshio Ohshima Laboratory for Molecular Brain Science Department of Life Science and Medical BioscienceGraduate School of Advanced Science and EngineeringWaseda UniversityTokyoJapan Biomolecular Engineering Laboratory Department of Life Science and Medical BioscienceGraduate School of Advanced Science and EngineeringWaseda UniversityTokyoJapan Computational Bio Big-Data Open Innovation Laboratory(CBBD-OIL) National Institute of Advanced Industrial Science and Technology(AIST)TokyoJapan Research Organization for Nano and Life Innovation Waseda UniversityTokyoJapan Institute for Advanced Research of Biosystem Dynamics Waseda Research Institute for Science and EngineeringGraduate School of Advanced Science and EngineeringWaseda UniversityTokyoJapan Cellular and Molecular Biotechnology Research Institute National Institute of Advanced Industrial Science and Technology(AIST)TsukubaJapan Department of Molecular Pharmacology and Neurobiology Graduate School of MedicineYokohama City UniversityYokohamaJapan

Recent studies have shown that mutation at Ser522 causes inhibition of collapsin response mediator protein 2(CRMP2) phosphorylation and induces axon elongation and partial recovery of the lost sensorimotor function after spinal cord injury(SCI).We aimed to reveal the intracellular mechanism in axotomized neurons in the CRMP2 knock-in(CRMP2KI) mouse model by performing transcriptome analysis in mouse sensorimotor cortex using micro-dissection punching *** to that, we analyzed the structural pathophysiology in axotomized or neighboring neurons after SCI and found that somatic atrophy and dendritic spine reduction in sensorimotor cortex were suppressed in CRMP2KI *** analysis of the transcriptome has aided in the identification of four hemoglobin genes Hba-a1, Hba-a2, Hbb-bs, and Hbb-bt that are significantly upregulated in wild-type mice with concomitant upregulation of genes involved in the oxidative phosphorylation and ribosomal pathways after ***, we observed substantial upregulation in channel activity genes and downregulation of genes regulating vesicles, synaptic function, glial cell differentiation in CRMP2KI ***, the transcriptome profile of CRMP2KI mice has been discussed wherein energy metabolism and neuronal pathways were found to be differentially *** results showed that CRMP2KI mice displayed improved SCI pathophysiology not only via microtubule stabilization in neurons, but also possibly via the whole metabolic system in the central nervous system, response changes in glial cells, and *** together, we reveal new insights on SCI pathophysiology and the regenerative mechanism of central nervous system by the inhibition of CRMP2 phosphorylation at *** these experiments were performed in accordance with the guidelines of the Institutional Animal Care and Use Committee at Waseda University, Japan(2017-A027 approved on March 21, 2017;2018-A003 approved on March 25, 2018;2019-A026 approved on March

关键词： CNS regeneration cortex CRMP2 hemoglobin metabolic pathway spinal cord injury spine transcriptome

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QFide: Quantum Teleportation Fidelity Simulator for Developing Quantum Networks

QFide: Quantum Teleportation Fidelity Simulator for Developi...

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Quantum Communications, Networking, and Computing (QCNC), International Conference on

作者： Yuto Lim Zhaowei Zhong Jianwen Sun Thu Trang Nguyen Ruidong Li Graduate School of Advanced Science and Technology Japan Advanced Institute of Science and Technology Nomi City Japan Institute of Science and Engineering Kanazawa University Kanazawa City Japan

ISBN: (数字)9798331531591

ISBN: (纸本)9798331531607

This paper introduces QFide, a novel simulation tool for quantum teleportation that focuses on unraveling the influence of various environmental factors, such as noise and signal loss, which are critical in shaping the efficiency and reliability of quantum information transfer. Employing Qiskit as the simulator core, QFide adopts a multifaceted approach, integrating various noise models along with an Amplitude Damping Channel (ADC) loss model. Our evaluation study extends the detailed statistical analysis, utilizing statistical metrics and providing a quantifiable measure of fidelity in comparison to real-world experimental outcomes.

关键词： Measurement Damping Quantum entanglement Statistical analysis Noise Teleportation Environmental factors Reliability Quantum networks Quantum simulation

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Quantifying the Influences of Carbides and Porosities on the Fatigue Crack Evolution of a Ni-Based Single-Crystal Superalloy using X-ray Tomography

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Acta Metallurgica Sinica(English Letters) 2022年第1期35卷 133-145页

作者： Keli Liu Junsheng Wang Bing Wang Pengcheng Mao Yanhong Yang Yizhou Zhou School of Materials Science&Engineering Beijing Institute of TechnologyBeijing100081China Advanced Research Institute of Multidisciplinary Science Beijing Institute of TechnologyBeijing100081China Center for Micro and Nano Technologies Beijing Institute of TechnologyBeijing100081China Superalloys Division Institute of Metal ResearchChinese Academy of SciencesShenyang110016China

The detrimental effects of carbides and porosity on the fatigue crack initiation and propagation of nickel-based single-crystal superalloys have been reported by many previous ***,few studies have quantitatively compared the fatigue damaging effects of carbides and pores on the fatigue crack *** this study,a high-resolution X-ray computed tomography(XCT)characterization of a DD5 nickel-based single-crystal superalloy during fatigue test was *** evolution of carbides,pores and cracks at all stages was observed and *** order to quantify the 3D microstructures,a new damage factor that correlates the morphology of fracture surface with crack evolution behaviors was *** was found that porosity was more detrimental than carbides in crack initiation and propagation during fatigue ***,pore spacing has been found to be the most significant factor among all controlling pore characteristics in the crack initiation stage and sphericity is the most critical pore characteristic in the crack propagation ***,by statistically analyzing the evolution of carbides and pores during fatigue tests in this study,the underlying fatigue cracking mechanism of nickel-based superalloys is revealed.

关键词： X-ray tomography Ni-based superalloys Fatigue Porosity Carbide Crack initiation Crack propagation

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Nanotube-based heterostructures for electrochemistry: A mini-review on lithium storage, hydrogen evolution and beyond

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Journal of Energy Chemistry 2022年第7期31卷 630-642,I0016页

作者： Yongjia Zheng Wanyu Dai Xue-Qiang Zhang Jia-Qi Huang Shigeo Maruyama Hong Yuan Rong Xiang Department of Mechanical Engineering The University of TokyoTokyo 113-8656Japan Advanced Research Institute of Multidisciplinary Science Beijing Institute of TechnologyBeijing 100081China State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310027ZhejiangChina

Nanotube-based mixed-dimensional or one-dimensional heterostructures have attracted great attention recently because of their unique physical properties and therefore potential for novel devices. Their chemical properties, however, were less explored but can be utilized for energy storage and *** this review, we summarize the recent progress of nanotube-based low dimensional materials for electrochemistry, in particular, lithium storage and hydrogen evolution. First, we describe the atomic structure of low-dimensional heterostructures and briefly touch previous work on planar van der Waals heterostructures(2D+2D) in electrochemistry applications. Then we focus this review on the more recently developed nanotube-based, i.e., 1D+2D and 1D + 1D heterostructures, and discuss their various preparation approaches and electrochemical performances. Finally, we outline the challenges and opportunities in this direction and particularly emphasize the possibility of building high-performance electrodes using a single-walled carbon nanotube-based ultra-thin 1D heterostructure, and the importance of understanding the fundamental mechanism at atomic precision.

关键词： Lithium storage Hydrogen evolution Electrochemistry Van der Waals heterostructures Carbon nanotube

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Isomerization of various aldo-saccharides to the corresponding keto-saccharides under microwave heating using uncalcined scallop shell powder as a catalyst

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Food science and technology Research 2024年第3期30卷 305-311页

作者： Watanabe, Yoshiyuki Kobayashi, Takashi Khuwijitjaru, Pramote Adachi, Shuji Department of Applied Biological Chemistry Graduate School of Agriculture Osaka Metropolitan University Naka-ku Osaka Sakai599-8531 Japan Division of Food Science and Biotechnology Graduate School of Agriculture Kyoto University Sakyo-ku Kyoto606-8502 Japan Department of Food Technology Faculty of Engineering and Industrial Technology Silpakorn University Nakhon Pathom73000 Thailand Department of Agriculture and Food Technology Faculty of Bioenvironmental Sciences Kyoto University of Advanced Science Kyoto Kameoka621-8555 Japan

Fifty milliliters of 0.2 mol/L aqueous solutions containing two aldo-pentoses (ribose and xylose), two aldo-hexoses (glucose and galactose), and two aldo-disaccharides (cellobiose and lactose) were placed in a pressure-resistant vessel along with 0.5 g of uncalcined scallop shell powder and heated by a microwave oven at 700 W to isomerize the aldo-saccharides to the corresponding keto-saccharides (ribulose and xylulose, fructose and tagatose, and cellobiulose and lactulose). The yields of keto-saccharides were approximately 10 % for pentoses, 18 % for hexoses, and 25 % for disaccharides within 105 s. The selectivity from aldo-saccharide to the keto-saccharide followed the order of disaccharide > hexose > pentose. Measurements were taken for pH, calcium ion concentration, and absorbance at 280 nm and 420 nm. The acidic by-products formed during heating were neutralized by the shell powder, maintaining the pH of the reaction mixture above 7 to promote isomerization through Lobry de Bruyn–Alberda van Ekenstein transformation. Copyright©2024, Japanese Society for Food science and technology.

关键词： Microwave heating

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InNi alloy-induced interface effect promoting the parallel electron transfer: improved photothermal catalytic CO2 hydrogenation

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science China Chemistry 2025年第6期 2725-2734页

作者： Haoyu Zhang Yu-Hang Li Yu Nie Xinyu Dou Haodong Ji Xin Tan Jinhua Ye Tao Yu School of Chemical Engineering and Technology Tianjin University Eco-environment and Resource Efficiency Research Laboratory School of Environment and Energy Peking University Shenzhen Graduate School School of Environmental Science and Engineering Tianjin University Advanced Catalytic Materials Research Center School of Materials Science and Engineering Tianjin University Research Center for Solar Driven Carbon Neutrality Hebei University

Photothermal catalytic CO2hydrogenation is an effective means of utilizing carbon resources. However, it is severely limited in terms of kinetics and thermodynamics. Therefore, it is necessary to meticulously design catalysts to solve this problem. Herein, a sandwich structured Ni O@In Ni/In2O3is designed to intrinsically regulate the direction of photogenerated carriers transfer,resulting in a CO yield of 42.97 mmol g-1h-1(1290.3 μmol h-1) with a selectivity near to 100%. In Ni alloy favors the collection of photogenerated carriers by the parallel way and enhancement of the adsorption and activation of CO2molecules. NiO grown on the surface of In Ni alloy not only improves the adsorption of H2and provides sufficient H+for the reaction, but also makes In Ni alloy more stable during the reaction process. The photothermal effect caused by In2O3accelerates the transfer of photogenerated carriers and increases the surface temperature of the catalyst, thereby synergistically promoting the reaction from a kinetic perspective. This work ameliorates the kinetic and thermodynamic limitations of the photothermal catalytic CO2hydrogenation process through rationally designing the electron transfer direction of the sandwich structured catalysts to parallel way.

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Machine learning-accelerated discovery of novel 2D ferromagnetic materials with strong magnetization

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Chip 2023年第4期2卷 78-88页

作者： Chao Xin Yaohui Yin Bingqian Song Zhen Fan Yongli Song Feng Pan School of Science Changchun University of Science and TechnologyJilin Key Laboratory of Solid-State Laser Technology and ApplicationChangchun 130022China School of Advanced Materials Peking University Shenzhen Graduate SchoolShenzhen 518055China Center forLattice Defectronics&Department of Physics KAISTDaejeon 34141Republic of Korea School of Energy and Power Engineering JiangSuUniversityZhenjiang 212013China

Two-dimensional ferromagnetic(2DFM)semiconductors(metals,half-metals,and so on)are important materials fornext-generation nano-electronic and nano-spintronic ***,these kinds of materials remain scarce,“trial anderror”experiments and calculations are both time-consumingand *** the present work,in order to obtain theoptimal 2DFM materials with strong magnetization,a machinelearning(ML)framework was established to search the 2Dmaterial space containing over 2417 samples and identified 615compounds whose magnetic orders were then determined viahigh-throughput first-principles *** the adoptionof ML algorithms,two classification models and a regressionmodel were *** interpretability of the regressionmodel was evaluated through Shapley Additive exPlanations(SHAP)***,it is found that Cr2NF2 is apotential antiferromagnetic ferroelectric 2D multiferroic *** importantly,60 novel 2DFM candidates werepredicted,and among them,13 candidates have magnetic moments of>7μ***2Cl8,Fe3GeSe2,and Mn4N3S2 were predictedto be novel 2DFM semiconductors,metals,and half-metals,*** the adoption of the ML approach in thecurrent work,the prediction of 2DFM materials with strongmagnetization can be accelerated,and the computation timecan be drastically reduced by more than one order ofmagnitude.

关键词： 2D ferromagnetic Machine learning High through-putscreening DFT Model interpretability

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Dual-Mode Spatial Division Multiplexing with Geometric Constellation Shaping for UVLC

Dual-Mode Spatial Division Multiplexing with Geometric Const...

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2023 Asia Communications and Photonics Conference/2023 International Photonics and Optoelectronics Meetings, ACP/POEM 2023

作者： Wang, Jiwei Chen, Chen Deng, Bohua Liu, Min He, Cuiwei Fu, H.Y. School of Microelectronics and Communication Engineering Chongqing University Chongqing China Tsinghua Shenzhen International Graduate School Tsinghua University Shenzhen China School of Information Science Japan Advanced Institute of Science and Technology Ishikawa Japan

A dual-mode spatial division multiplexing (DM-SDM) scheme with geometric constellation shaping (GCS) is proposed for underwater visible light communication (UVLC) systems. Simulation and experimental results successfu... 详细信息

ISBN: (纸本)9798350312614

关键词： Dual-mode index modulation spatial division multiplexing underwater visible light communication

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Elite-guided equilibrium optimiser based on information enhancement:Algorithm and mobile edge computing applications

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CAAI Transactions on Intelligence technology 2024年第5期9卷 1126-1171页

作者： Zong-Shan Wang Shi-Jin Li Hong-Wei Ding Gaurav Dhiman Peng Hou Ai-Shan Li Peng Hu Zhi-Jun Yang Jie Wang School of Information Science and Engineering Yunnan UniversityKunmingChina Shenzhen Institute for Advanced Study University of Electronic Science and Technology of ChinaShenzhenChina Academic Affairs Office Yunnan University of Finance and EconomicsKunmingChina Faculty of Management and Economics Kunming University of TechnologyKunmingChina Department of Electrical and Computer Engineering Lebanese American UniversityBeirutLebanon Department of Computer Science and Engineering University Centre for Research and DevelopmentChandigarh UniversityChennaiIndia Department of Computer Science and Engineering Graphic Era Deemed to Be UniversityDehradunIndia School of Computer Science Fudan UniversityShanghaiChina Rackham Graduate School University of MichiganAnn ArborMIUSA Research and Development Department Youbei Technology Co.LTDKunmingChina School of Mechanical and Power Engineering Zhengzhou UniversityZhengzhouChina

The Equilibrium Optimiser(EO)has been demonstrated to be one of the metaheuristic algorithms that can effectively solve global optimisation *** the paradox between exploration and exploitation operations while enhancing the ability to jump out of the local optimum are two key points to be addressed in EO *** alleviate these limitations,an EO variant named adaptive elite-guided Equilibrium Optimiser(AEEO)is ***,the adaptive elite-guided search mechanism enhances the balance between exploration and *** modified mutualism phase reinforces the information interaction among particles and local optima *** cooperation of these two mechanisms boosts the overall performance of the basic *** AEEO is subjected to competitive experiments with state-of-the-art algorithms and modified algorithms on 23 classical benchmark functions and IEE CEC 2017 function test *** results demonstrate that AEEO outperforms several well-performing EO variants,DE variants,PSO variants,SSA variants,and GWO variants in terms of convergence speed and *** addition,the AEEO algorithm is used for the edge server(ES)placement problem in mobile edge computing(MEC)*** experimental results show that the author’s approach outperforms the representative approaches compared in terms of access latency and deployment cost.

关键词： ANT COLONY optimization CLOUD COMPUTING GENETIC ALGORITHMS SWARM intelligence

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High-strength aluminum alloys hollow billet prepared by two-phase zone continuous casting

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China Foundry 2022年第3期19卷 253-262页

作者： Yao-hua Yang Xue-feng Liu Wang-zhang Chen Beijing Advanced Innovation Center for Materials Genome Engineering University of Science and Technology BeijingBeijing 100083China Beijing Laboratory of Metallic Materials and Processing for Modern Transportation University of Science and Technology BeijingBeijing 100083China Key Laboratory for Advanced Materials Processing of Ministry of Education University of Science and Technology BeijingBeijing 100083China Shunde Graduate School University of Science and Technology BeijingFoshan 528399GuangdongChina

The two-phase zone continuous casting(TZCC)technique was used to continuously cast high-strength aluminum alloy hollow billets,and a verified 3D model of TZCC was used to simulate the flow and temperature fields at casting speeds of 2-6 mm·min^(-1).Hollow billets under the same conditions were prepared,and their macro/microstructures were analyzed by an optical microscope and a scanning electron *** the TZCC process,a circular fluid flow appears in front of the mushy zone,and the induction heated stepped mold and convective heat transfer result in a curved solidification front with depressed region near the inner wall and a vertical temperature *** deflection of the solidification front decreases and the average cooling rate in the mushy zone increases with increasing casting *** results for a 2D12 alloy show that hot tearing periodically appears in the hollow billet accompanied by macrosegregation near the inner wall at casting speeds of 2 and 4 mm·min^(-1),while macroscopic defects of hot tearing and macrosegregation weaken and the average size of columnar crystals in the hollow billets decreases with further increasing casting speed.2D12 aluminum alloy hollow billets with no macroscopic defects,the finest columnar crystals,and excellent mechanical properties were prepared by TZCC at a casting speed of 6 mm·min^(-1),which is beneficial for the further plastic forming process.

关键词： two-phase zone continuous casting high-strength aluminum alloy hollow billet fluid flow heat transfer columnar crystals

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