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Elastic-plastic beam-column fem model with fiber elements evaluating shear deformation

Journal of Structural and Construction engineering 2017年第737期82卷 1035-1045页

作者： Wang, Dan Hayashi, Yoshiki Muramoto, Makoto Morisako, Kiyotaka Graduate School of Science and Technology Doctoral Program of Design Science Kyoto Institute of Technology Japan Maeda Corporation Japan Faculty of Design and Architecture Kyoto Institute of Technology Japan

This paper proposes a new beam-column FEM which consists of several fiber elements considering shear deformation. The shear strain in each fiber element is assumed by shear deformation angle and distribution of shear strain at the elastic state. The formulation is accomplished based on the incremental perturbation method. Normal stress-strain relation and shear stress-strain relation in the fiber element are supposed here to obey each different consistent law independently. The verification of the proposed numerical method named FERTs-P is carried out for the problem of elastic beam, elastic-plastic beam. The simulation of the steel beam experiment and the frame experiment with a shear panel are done by the FERTs-P. The ratios of shear deformation to bending deformation in elastic beams are almost coincident with theoretical values. The numerical results by the FERTs-P are relatively good predictions for load-deflection curves of beams and frame yielding at shear. In spite of bold modeling, this numerical method may be expected considerably. © 2017 Architectural Institute of Japan. All rights reserved.

关键词： Finite element method

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Bioprospecting microalgal strains cultivated using bicarbonate under a pH-regulated regime for enhanced carbon capture and utilization

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Algal Research 2025年 89卷

作者： Latagan, Mary Joy D. Nagarajan, Dillirani Chen, Jih-Heng Huang, Wei-Ming Chen, Chun-Yen Pacquiao, Melvin R. de Luna, Mark Daniel G. Rollon, Analiza P. Chang, Jo-Shu Department of Chemical Engineering National Cheng Kung University Tainan 701 Taiwan Energy Engineering Program National Graduate School of Engineering University of the Philippines Diliman Quezon City 1101 Philippines Institute of Aquatic Science and Technology College of Hydrosphere Science National Kaohsiung University of Science and Technology Kaohsiung City 811532 Taiwan Department of Chemical and Materials Engineering National Kaohsiung University of Science and Technology Kaohsiung 807 Taiwan University Center for Bioscience and Biotechnology National Cheng Kung University Tainan 701 Taiwan Department of Biomedical Engineering National Cheng Kung University Tainan 701 Taiwan Department of Biotechnology and Bioindustry Sciences National Cheng Kung University Tainan 701 Taiwan Environmental Engineering Program National Graduate School of Engineering University of the Philippines Diliman Quezon City 1101 Philippines Department of Chemical Engineering University of the Philippines Diliman Quezon City 1101 Philippines Department of Chemical and Materials Engineering Tunghai University Taichung 407 Taiwan Department of Chemical Engineering and Materials Science Yuan Ze University Chung-Li Taiwan Department of Life Science National Chung Hsin University Taichung 402202 Taiwan Innovation and Development Center of Sustainable Agriculture National Chung Hsin University Taichung 402202 Taiwan

Microalgae offers significant potential as a sustainable resource for biofuel production. However, an inefficient supply of gaseous CO2 can lead to carbon limitation due to poor mass transfer efficiency, which poses a... 详细信息

Microalgae offers significant potential as a sustainable resource for biofuel production. However, an inefficient supply of gaseous CO₂ can lead to carbon limitation due to poor mass transfer efficiency, which poses a significant challenge in large-scale microalgal cultures. This study investigates pH-stat bicarbonate-based cultivation of various microalgal strains aimed at carbohydrate and lipid production. Four green algal strains were assessed for their capability to utilize bicarbonate ions as their inorganic carbon source for photosynthesis. Among the strains, Chlamydomonas sp. JSC4 attained the highest biomass concentration (1.05 ± 0.05 g/L), biomass productivity (242 mg/L/day), lipid content (42.7 ± 0.85 %), and carbohydrate content (39.16 ± 0.09 %) under conditions of 50 mM KHCO₃, pH 8, and 7 days of cultivation. The biomass productivity attained in this study is higher than those in the reported literature. The predicted biodiesel quality for all strains met the ASTM D6751 and EN 14214 specifications. Increasing the bicarbonate concentration to 100 mM and employing a fed-batch mode elevated the biomass to 1.45 ± 0.32 g/L, carbohydrate accumulation to 58.25 ± 1.28 % DCW, and carbon fixation efficiency to 63.8 ± 3.23 %, which is significantly higher than that of the control cultivated with CO₂ supply (0.30 ± 0.04 %). This study highlights the potential of bicarbonate ion supplementation as an effective strategy for maximal biomass production with high productivity and biomolecule accumulation, aiding in the realization of cost-effective microalgal biofuel production. © 2025 Elsevier B.V.

关键词： Bicarbonate Biofuel Carbohydrate Chlamydomonas Microalgae pH-stat culture

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Simultaneous assessment of blood flow changes in femoral artery and skeletal muscle microvasculature using pulsed-wave and power Doppler ultrasonography

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European journal of applied physiology 2025年 2025 May 14页

作者： Kazuma Izumi Kana Shiozawa Yutaka Kano Keisho Katayama Noriko Tanaka Hiroshi Akima Graduate School of Education and Human Development Nagoya University 1 Furo Chikusa Nagoya Aichi 464-8601 Japan. izumi.kazuma.r0@s.mail.nagoya-u.ac.jp. Graduate School of Medicine Nagoya University 65 Tsurumai Showa Nagoya Aichi 466-8550 Japan. Research Fellow of Japan Society for the Promotion of Science 5-3-1 Kojimachi Chiyoda Tokyo 102-0083 Japan. Department of Engineering Science Bioscience and Technology Program University of Electro-Communications 1-5-1 Chofugaoka Chofu Tokyo 182-8585 Japan. Research Center of Health Physical Fitness and Sports Nagoya University 1 Furo Chikusa Nagoya Aichi 464-8601 Japan. Graduate School of Education and Human Development Nagoya University 1 Furo Chikusa Nagoya Aichi 464-8601 Japan.

PURPOSE:The purpose of this study was to evaluate blood flow changes in femoral artery and skeletal muscle microvasculature during intermittent submaximal isometric knee extension. METHODS:Seventeen healthy young males (19.7 ± 1.2 years) performed intermittent (5 s on, 5 s off) isometric knee extension. Five contractions were performed at each force level of 10%, 30%, 50%, and 70% of maximal voluntary contraction (MVC) at random with a 10-min rest between sets. We measured right femoral artery blood flow by pulsed-wave Doppler ultrasonography and intramuscular blood flow in the vastus lateralis of the right mid-thigh by power Doppler ultrasonography, simultaneously. Both femoral artery and intramuscular blood flow were normalized by the peak value for each participant and represented as %Peak. Time-to-peak was defined as the time from the end of exercise to the peak. RESULTS:%Peak of femoral artery blood flow was significantly higher than that of intramuscular blood flow at the baseline and following contractions at 10% MVC (P < 0.01). The time-to-peak during the post-exercise of intramuscular blood flow was significantly longer than that of femoral artery blood flow following contractions at 70% MVC (P < 0.01). CONCLUSIONS:These results indicate that blood flow increases appeared slowly in skeletal muscle microvasculature than in femoral artery after intermittent submaximal isometric knee extension, suggesting that differences in vascular reactivity and blood flow regulation could exist between femoral artery and skeletal muscle microvasculature in healthy young males.

关键词： Exercise Femoral artery blood flow Intramuscular blood flow Muscle oxygenation Power Doppler ultrasonography

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Efficient production of cell-encapsulated microgels using flicking technique

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Journal of Drug Delivery science and technology 2025年 108卷

作者： Torabi-Rahvar, Parisa Noohi, Parisa Abdekhodaie, Mohammad J. Shafiee, Mohammad A. Department of Chemical Engineering Sharif University of Technology Tehran Iran Tissue Engineering for Orthopaedic & Mechanobiology Bone & Joint Program Department for BioMedical Research (DBMR) Medical Faculty University of Bern Bern Switzerland Environmental and Applied Science Management Yeates School of Graduate Studies Toronto Metropolitan University Toronto Canada Division of General Internal Medicine Department of Medicine University of Toronto Toronto Canada

In this study, a simple flicking-base method was developed for the mass production of uniform alginate microgels. A comprehensive investigation was conducted to determine the relationship between the microencapsulation parameters and the size as well as the sphericity of the microgels. Fractional factorial design (FFD) was employed to determine the main factors affecting microgel size, identifying flow rate, alginate concentration, and motor speed as the most influential. Furthermore, the simultaneous effect of these critical factors on microgel size and sphericity was modeled using central composite design (CCD). The resulting quadratic empirical models offered insights into the jet break process in flicking-based microencapsulation and enabled the selection of factors and their levels to generate appropriately sized and shaped alginate microgels. Spherical microgels with a minimum size of 528 ± 20 μm were obtained at a flow rate of 5.8 ml/h, alginate concentration of 2 %, and motor speed of 17.1 Hz. Human mesenchymal stem cells were successfully encapsulated in the microgels with high cell viability exceeding 90 %. This study highlights the flicking method as a promising technique for efficiently producing uniform cell-encapsulated alginate microgels. The simplicity and cost-effectiveness of this method make it an available option for practical laboratory research, enabling the efficient preparation of microgels with adjustable size and shape. Furthermore, this microencapsulation approach has potential applications in tissue engineering, pharmaceutical disease models, cell-based transplantation, and regenerative medicine. © 2025

关键词： Alginate Cell microencapsulation Flicking technique Microgels Response surface methodology

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The experience design of the bamboo craft of laiji tribe in alishan township

The experience design of the bamboo craft of laiji tribe in ...

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2017 IEEE International Conference on Applied System Innovation, ICASI 2017

作者： Dai, Ying Hwang, Shyh-Huei Graduate School of Design Doctoral Program National Yunlin University of Science and Technology Taiwan

ISBN: (纸本)9781509048977

The Laiji's cultural heritage is rich in bamboo characteristics, but the scope of application is limited. This study uses literature analysis, participation observation, in-depth interview, and action research to analyze the existing bamboo utilization of the Laiji tribe, the bamboo artwork of craftsmen, and the experience design for bamboo. The results show that: (1) Laiji's bamboois almost exclusively used for bamboo food and the walls of the sacrificial house;(2) the sweet point is designed to be close to the natural unfixable place and spiritof the bamboo craftsmen'sguileless study of the craft;(3) the pain point of the Laiji tribe's bamboo experiencedesign is a lack of clarity, interestingness, manpower, technology, and project category. © 2017 IEEE.

关键词： Bamboo

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Antioxidant system alterations and oxidative stress caused by polyfluoroalkyl substances (PFAS) in exposed biota: a review

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science of the Total Environment 2025年 977卷 179395页

作者： Soares, Lorena Oliveira Souza de Araujo, Gabriel Farias Gomes, Thais Braga Júnior, Sidney Fernandes Sales Cuprys, Agnieszka Katarzyna Soares, Raquel Moraes Saggioro, Enrico Mendes Laboratory of Environmental Health Assessment and Promotion Oswaldo Cruz Institute Oswaldo Cruz Foundation Av. Brasil 4365 RJ Rio de Janeiro21045-900 Brazil Post-Graduate Program in Public Health and Environment Sergio Arouca National School of Public Health Oswaldo Cruz Foundation Av. Leopoldo Bulhões 1480 RJ Rio de Janeiro21041-210 Brazil Faculty of Science and Technology Norwegian University of Life Sciences P.O. Box 5003 Ås1432 Norway Post-Graduate Program in Environmental Technology and Water Resources Department of Civil and Environmental Engineering – FT University of Brasília Darcy Ribeiro Campus Via L3 Norte DF Brasília70910-900 Brazil

Contamination of aquatic and terrestrial organisms by Perfluoroalkyl substances (PFAS), emerging contaminants, is widespread, as these compounds are present in water, soil, air, and food, owing to their environmental persistence. PFAS exposure induces biochemical process alterations associated with the disruption of the antioxidant defense system in several species. This review aims to discuss how PFAS-induced antioxidant system alterations lead to changes in biochemical processes in different organisms exposed to these pollutants. This disruption, then leads to an imbalance in antioxidant defense systems, contributing to the formation of reactive oxidative species (ROS), which, in turn, can be exacerbate oxidative stress, induce cellular damage, enhance lipid peroxidation, destabilize lysosomal membranes, and cause genotoxic effects, ultimately compromising DNA integrity. In acute tests, PFAS have led to mortality, growth inhibition, diminished behavioral and locomotor abilities, and reproductive impairment. PFAS-induced effects differ with varying species or types of substances, and further bioaccumulation through food chains exacerbates environmental contamination, carrying considerable risks. These findings demonstrate the complex and enduring impact of PFAS on environmental health, emphasizing the importance of this review in corroborating studies on sub-lethal toxicity in exposed organisms and how these effects reflect on the environment. © 2025 Elsevier B.V.

关键词： Biotic

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Research on the matching relationship of municipal solid waste management and alternative fuel in Indonesia's cement industry

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Case Studies in Chemical and Environmental engineering 2025年 11卷

作者： Wiharja Suherman Syafrudin Kholiq, Muhammad Abdul Pratama, Reba Anindyajati Robbani, Muhammad Haqqiyuddin Suryanto, Feddy Doctoral Program of Environmental Science School of Postgraduate Studies Diponegoro University Central Java Semarang 50275 Indonesia Research Center for Environmental and Clean Technology National Research and Innovation Agency Banten South Tangerang 15314 Indonesia Department of Chemical Engineering Faculty of Engineering Diponegoro University Central Java Semarang 50275 Indonesia Department of Environmental Engineering Faculty of Engineering Diponegoro University Central Java Semarang 50275 Indonesia Directorate of Environment Maritime Natural Resources and Nuclear Policy National Research and Innovation Agency Jakarta 10340 Indonesia

The cement industry in Indonesia, heavily relies on coal, contributing significantly to greenhouse gas (GHG) emissions. Simultaneously, Java Island generates over 23 million tons of municipal solid waste (MSW) annually, with limited utilization for energy recovery. This study evaluates the feasibility of substituting coal with refuse-derived fuel (RDF) from MSW in Java's cement industry, focusing on environmental, economic, and technical aspects. Scenario analyses indicate that substituting 10%, 20%, and 30% of thermal energy with RDF could divert up to 8.7 million tons of MSW from landfills annually, reducing GHG emissions by up to 2.77 million Gg CO₂-eq. These reductions align with Indonesia's environmental policies and global climate commitments under the Paris Agreement. The economic assessment demonstrates the viability of RDF, with potential annual cost savings of up to $421 million. Beyond addressing coal dependency, RDF adoption supports circular economy practices, reduces landfill reliance, and mitigates environmental pollution. However, challenges such as infrastructure gaps and regulatory barriers require attention. This study provides actionable insights to guide policy formulation, foster industry investment, and facilitate the implementation of RDF-based energy solutions. By bridging waste management and sustainable energy practices, the findings contribute to Indonesia's renewable energy goals, emphasizing the practical applications of RDF for a more sustainable future in industrial operations. © 2025 The Authors

关键词： Alternative fuel Cement industry Municipal solid waste Refused-derived fuel Sustainable energy

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Evaluation of ultrasonic-range Vibratory Microinjection System at a frequency of 35 kHz using fertilized mouse eggs

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Journal of Mammalian Ova Research 2012年第1期29卷 48-54页

作者： Kudereti, Dilidaer Miyawaki, Fujio Kobayashi, Kenji Hasegawa, Jun Graduate School of Advanced Science and Technology Doctoral Program Tokyo Denki University Saitama 350-0394 Japan Graduate School of Engineering Takushoku University Tokyo 193-0985 Japan

To facilitate pronuclear microinjection, we have been developing the Vibratory Microinjection Systems (VMSs) that provides a micropipette with longitudinal vibration. The current VMS utilizes any frequency up to 100 kHz. We compared 35-kHz vibratory microinjection (VM) with ordinary microinjection (OM). Fourteen micropipettes were used to inject 420 BDF1 zygotes. Each micropipette finished its injection quota of 30 eggs, which were manipulated one by one alternately using the two types of microinjections, even when it repeatedly pulled out nuclear components. All microinjections were conducted at a compensation pressure of 30 hPa and digitally recorded for subsequent image analysis. VM resulted in slightly better embryonic development in 4-day culture than OM, but significantly shortened the time spent on microinjection and the time spent swelling the pronucleus by 25% and 30%, respectively. These pronuclear swelling times, together with the almost identical degrees of pronuclear swelling in both groups, suggested that VM injected a GFP solution at a 42% higher speed. VM significantly reduced the incidence of pulling out nuclear components, suggesting VM's capability of removing the nuclear components already adhering to the micropipettes. These results indicate VMS is a useful option which is capable of raising the efficiency of microinjection significantly by saving time, labor and cost of microinjection. © 2012 Japanese Society of Mammalian Ova Research.

关键词： Injection speed Longitudinal vibration Microinjection Ultrasonic-range vibration Working efficiency

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Transplantation of human kidney organoids elicited a robust allogeneic response in a humanized mouse model

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Kidney International 2025年第6期107卷 1011-1016页

作者： Mon-Wei Yu, Samuel Choi, John Yongjoon Kady, Jamie De Cos, Marina Wong, Jenny S. King, Emily Younis, Nour Al Rahy, Nadim Al Chaar, Soltan Djebli, Houda Eskandari, Siawosh Samuel, Stephen Merhej, Tamara Sukumar, Nivedha Lin, Jia-Ren Chen, Jia-Yun Xu, Yilin Santagata, Sandro Weins, Astrid Yeung, Melissa Cravedi, Paolo Campbell, Kirk N. Lemos, Dario Bonventre, Joseph V. Brehm, Michael A. Azzi, Jamil Department of Medicine Nephrology Division Mount Sinai Hospital New York NY United States Department of Medicine Renal Division Brigham and Women's Hospital Harvard Medical School Boston MA United States Program in Molecular Medicine Diabetes Center of Excellence University of Massachusetts Chan Medical School Worcester MA United States Doctoral School of Science and Technology Lebanese University Beirut Lebanon Institute of Biological Science Faculty of Medical Sciences Mohammed VI Polytechnic University Benguerir Morocco Department of Biotechnology Northeastern University Boston MA United States Department of Systems Biology Harvard Medical School Boston MA United States Department of Pathology Brigham and Women's Hospital Harvard Medical School Boston MA United States Harvard Stem Cell Institute Cambridge MA United States Department of Medicine Division of Engineering in Medicine Brigham and Women's Hospital Harvard Medical School Boston MA United States

Human kidney organoids derived from embryonic stem cells (ESCs) or induced pluripotent stem cells (iPSCs) have become novel tools for studying various kidney pathologies. Here, we transplanted ESC-derived kidney organoids into humanized mice with a mature human adaptive immune system developed through thymic education. As judged by histology and immunophenotyping, the transplanted HLA-mismatched kidney organoids trigged a robust alloimmune response, characterized by a dense immune cell infiltrate and enhanced memory T cell phenotype in the allograft 30 days post-transplantation. Multiplexed immunofluorescence revealed expression of functional markers of various immune cell infiltrates in response to organoid allografts, mimicking the T cell-mediated rejection process in humans. This validated our model as a novel platform to study various therapeutic strategies to control alloimmunity. Splenocytes isolated from organoid-transplanted hosts showed an alloantigen-specific memory response against 2D kidney organoids ex vivo. Overall, our study indicates that transplanting kidney organoids in humanized mice may be a valuable tool for studying human allogeneic immunity. © 2025 International Society of Nephrology

关键词： human kidney organoids humanized mice model kidney transplantation

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On design methodology and practice of bionics

On design methodology and practice of bionics

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3rd IEEE International Conference on Digital Game and Intelligent Toy Enhanced Learning, DIGITEL 2010

作者： Chiu, Wan-Ting Chiou, Shang-Chia Graduate School of Design Doctoral Program National Yunlin University of Science and Technology Yunlin Taiwan

ISBN: (纸本)9780769539935

It has been 50 years since Bionics were first being studied and developed. However, the findings and scholars in Bionics were rather deficient comparing with its developing history, and that made Bionics unable to become a leading subject among all the other disciplines, let alone the achievements of Bionic applications to designing. Under the principle of interdisciplinary research, this study has reviewed the concepts and knowledge system of Bionic design, and further by the given examples of the Biology of crabs, this study has also analyzed a hands-on practice in applying the Biological knowledge to designing. The logic of Bionic design, which is also the ultimate expectation of this study - is to reload and transform the elements of Biology and technology/material after the comprehension of Biological knowledge. To sum up, this study aims to inference the education approaches of Bionic design, and to construct and analyze the methodology of Bionic design by the achievements of former approaches. Aimed at the third year university students in Taiwan, the hands-on practice revealed the following effects: 1. the designers usually have a good sense on connecting the shape and functions of organism to the product design, and result in a visual completeness. 2. Knowledge of different organisms indeed enriches education, thought and sense, and opens up a new route of designing. 3. Interdisciplinary study is necessary for breaking the closed subjects, and for accepting another new knowledge to widen the view. I believe this worth a better development by more designers and researchers in the future. © 2010 IEEE.

关键词： Bionics

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