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Gut microbiota composition can reflect immune responses of latent tuberculosis infection in patients with poorly controlled diabetes

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Respiratory research 2023年第1期24卷 11页

作者： Hung-Ling Huang Yong-Chun Luo Po-Liang Lu Cheng-Hsieh Huang Kun-der Lin Meng-Rui Lee Meng-Hsuan Cheng Yao-Tsung Yeh Cheng-Yuan Kao Jann-Yuan Wang Jinn-Moon Yang Inn-Wen Chong Division of Pulmonary and Critical Care Medicine Kaohsiung Medical University Hospital 100 Shih-Chuan 1st Road Kaohsiung 80708 Taiwan. Department of Internal Medicine Kaohsiung Medical University Hospital 100 Shih-Chuan 1st Road Kaohsiung 80708 Taiwan. Department of Internal Medicine Kaohsiung Municipal Ta-Tung Hospital 68 Jhonghua 3rd Rd Cianjin District Kaohsiung 80145 Taiwan. Graduate Institute of Medicine College of Medicine Kaohsiung Medical University 100 Shih-Chuan 1st Road Kaohsiung 80708 Taiwan. Institute of Bioinformatics and Systems Biology National Yang Ming Chiao Tung University 1001 University Road Hsinchu 30010 Taiwan. Center for Liquid Biopsy and Cohort Kaohsiung Medical University 100 Shih-Chuan 1st Road Kaohsiung 80708 Taiwan. Aging and Disease Prevention Research Center Fooyin University 151 Jinxue Rd. Daliao Dist. Kaohsiung 83102 Taiwan. Ph. D. Program in Environmental and Occupational Medicine Kaohsiung Medical University 100 Shih-Chuan 1st Road Kaohsiung 80708 Taiwan. Department of Medical Laboratory Science and Biotechnology Fooyin University 151 Jinxue Rd. Daliao Dist. Kaohsiung 83102 Taiwan. Division of Endocrinology and Metabolism Kaohsiung Medical University Hospital 100 Shih-Chuan 1st Road Kaohsiung 80708 Taiwan. Department of Internal Medicine National Taiwan University Hospital 7 Chung-Shan South Rd. Zhongzheng Dist. Taipei 100225 Taiwan. Department of Respiratory Therapy Kaohsiung Medical University Hospital 100 Shih-Chuan 1st Road Kaohsiung 80708 Taiwan. Immunology Research Center National Health Research Institutes 35 Keyan Road Zhunan Town Miaoli 35053 Taiwan. Department of Internal Medicine National Taiwan University Hospital 7 Chung-Shan South Rd. Zhongzheng Dist. Taipei 100225 Taiwan. jywang@ntu.edu.tw. Institute of Bioinformatics and Systems Biology National Yang Ming Chiao Tung University 1001 University Road Hsinchu 30010 Taiwan. moon@faculty.nctu.edu.tw. Department of Biologica

BACKGROUNd:diabetes mellitus (dM) is a major risk factor for tuberculosis (TB). Evidence has linked the dM-related dysbiosis of gut microbiota to modifiable host immunity to Mycobacterium tuberculosis infection. However, the crosslinks between gut microbiota composition and immunological effects on the development of latent TB infection (LTBI) in dM patients remain uncertain. METHOdS:We prospectively obtained stool, blood samples, and medical records from 130 patients with poorly-controlled dM (pdM), defined as ever having an HbA1c > 9.0% within previous 1 year. Among them, 43 had LTBI, as determined by QuantiFERON-TB Gold in-Tube assay. The differences in the taxonomic diversity of gut microbiota between LTBI and non-LTBI groups were investigated using 16S ribosomal RNA sequencing, and a predictive algorithm was established using a random forest model. Serum cytokine levels were measured to determine their correlations with gut microbiota. RESULTS:Compared with non-LTBI group, the microbiota in LTBI group displayed a similar alph.-diversity but different beta-diversity, featuring decrease of Prevotella_9, Streptococcus, and Actinomyces and increase of Bacteroides, Alistipes, and Blautia at the genus level. The accuracy was 0.872 for the LTBI prediction model using the aforementioned 6 microbiome-based biomarkers. Compared with the non-LTBI group, the LTBI group had a significantly lower serum levels of IL-17F (p = 0.025) and TNF-α (p = 0.038), which were correlated with the abundance of the aforementioned 6 taxa. CONCLUSIONS:The study results suggest that gut microbiome composition maybe associated with host immunity relevant to TB status, and gut microbial signature might be helpful for the diagnosis of LTBI.

关键词： diabetic mellitus Gut microbiota Immunity Latent tuberculosis infection

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Correction: Advanced anti-corrosion coatings prepared from α-zirconium ph.sph.te/polyurethane nanocomposites

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RSC Advances 2017年第36期7卷 22540-22540页

作者： Tsao-Cheng Huang Guan-Hui Lai Chen-En Li Mei-Hui Tsai Peng-Yun Wang Yi-Hsiu Chung Meng-Hung Lin Department of Chemical and Materials Engineering National Chin-Yi University of Technology 41170 Taichung Taiwan Republic of China Ph. D. Program Graduate Institute of Precision Manufacturing National Chin-Yi University of Technology 41170 Taichung Taiwan Republic of China Department Chemical Engineering Tatung University 104 Taipei Taiwan Republic of China National Chung-Shan Institute of Science and Technology Aeronautical Systems Research Division 40722 Taichung Taiwan Republic of China

Correction for ‘Advanced anti-corrosion coatings prepared from α-zirconium ph.sph.te/polyurethane nanocomposites’ by Tsao-Cheng Huang et al., RSC Adv., 2017, 7, 9908–9913.

Correction for ‘Advanced anti-corrosion coatings prepared from α-zirconium ph.sph.te/polyurethane nanocomposites’ by Tsao-Cheng Huang et al., RSC Adv., 2017, 7, 9908–9913.

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Tfe Solberg Award

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Naval Engineers Journal 2009年第5期112卷

作者： dr. Roy L. Streit Since 1992 Dr. Streit has focused a significant amount of his energy to assignment problems in acoustic warfare data fusion systems. This work led him to the formulation of the PDD Principle a broadly useful theoretical method that enables the derivation of new classes of discrete-continuous estimation algorithms for solving assignment problems without requiring enumeration and pruning. In recognition of his outstanding work in this area Dr. Streit received the NAVSEA Scientist of the Year Award for 1997. Dr. Streit has also been pursuing avenues for analyzing the loss in broadband detection performance of an acoustic array in the presence of interferences. Because examining all possible separations between the signal and many interferers is infeasible he has proposed a Poisson process model for the number and location (s) of the interferers. In this same time period Dr. Streit has also been investigating issues in environmental modeling and localization by proposing a novel integral method for solving the bearings-only target motion analysis problem which enables a natural heuristic for compensating for mismatch between the model predictions and the real world. Most recently Dr. Streit has proposed the Numerical ACoustic Hull ARray (NACHAR) Project as a revolutionary and ambitious approach to hull array design. Its premise is that optimizing the detection capability of large hull arrays requires the full integration of hull sensor array and beamformer design processes. Because NACHAR crosses an unusual number of technical disciplines it involves researchers from several departments. The diversity of Dr. Streif s technical background makes him uniquely suited to lead the project Dr. Streifs truly impressive scientific achievements are complemented by a noteworthy list of professional activities that accentuate his value to Division Newport and the Navy. He represents the United States in The Technical Cooperation Program Maritime Activities Panel 9 (Sonar Technology) and participates in the Division New

for his significant engineering research and development in sonar array research and acoustic transient signals as set forth in the following

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The Social Affordances of the Internet for Networked Individualism

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Journal of Computer-Mediated Communication 2006年第3期8卷

作者： Barry Wellman Anabel Quan-Haase Jeffrey Boase Wenhong Chen Keith Hampton Isabel díaz Kakuko Miyata In 1965 moved from his Bronx High School of Science slide rule to IBM cards and an 029 keypunch in the bowels of Harvard University. Since then he's been primarily interested in the interplay between large-scale social processes and how people use technology to be connected at work and in the community. His NetLab research network is trying to get a handle on how the Internet fits into everyday life. Wellman founded the International Network for Social Network Analysis in 1976. He is a recent Chair of the Community section of the American Sociological Association has been nominated for the Chair of the Communication and Information Technology section of the ASA the Virtual Community focus area leader for SIGGROUP/ACM and a Executive Cmmittee member of the Association for Internet Researchers. Wellman's (co)edited books are: Social Structures: A Network Approach (2d ed CSPI 2003) Networks in the Global Village (Westview Press 1999) and The Internet in Everyday Life (Blackwell Publishers 2002). Address:Centre for Urban & Community Studies University of Toronto 455 Spadina Avenue Toronto Canada M5S 2G8. Fax: +1-416-978-7162 Address:Centre for Urban & Community Studies University of Toronto 455 Spadina Avenue Toronto M5S 2G8 Canada. Address:Massachusetts Institute of Technology 77 Mass. Ave. Room 9-522 Cambridge MA 02139. Address:IN3 Av. Tibidabo 47 08035 Barcelona Spain. Phone: +*** Fax: +***. Address:Department of Sociology Meiji Gakuin University 1-2-37 Shirokanedai Minato-ku Tokyo 108-8636 JAPAN. Phone: +81-3-5421-5565 Fax: +81-3-5421-5697. Doctoral student at the Faculty of Information Studies University of Toronto. She has been a Fellow of the Knowledge Media Design Institute and the McLuhan Program in Culture and Technology. Her articles address the nature of Internet-related social change for social integration and information flow. Her articles have examined the implications of these changes for communities and her thesis focuses on organizations. University of Toronto doctoral

We review the evidence from a number of surveys in which our NetLab has been involved about the extent to which the Internet is transforming or enhancing community. The studies show that the Internet is used for connectivity locally as well as globally, although the nature of its use varies in different countries. Internet use is adding on to other forms of communication, rather than replacing them. Internet use is reinforcing the pre-existing turn to societies in the developed world that are organized around networked individualism rather than group or local solidarities. The result has important implications for civic involvement.

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Application considerations for the dHP methodology

Application considerations for the DHP methodology

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International Joint Conference on Neural Networks (IJCNN)

作者： G.C. Lendaris T. Shannon Systems Science & Electrical Engineering Portland State University Portland OR USA Graduate Student Systems Science Ph. D Program Portland State University Portland OR USA

Six questions are posed that are likely to be of interest to one considering applying the dual heuristic programming (dHP) methodology. Tentative answers to these questions are provided in the last section of the paper. As a basis for these, the paper first describes observations made from a series of explorations into various aspects of using the dHP method to design the controller for the pole-cart benchmark problem. Parameters of the explorations included training gains, plant parameter variations, fidelity of plant model, controller sampling rates, network architectures, training strategies, and generalization tests.

关键词： Neural networks Sampling methods Equations design optimization design methodology Benchmark testing Mathematical programming Process design Analytical models Signal generators

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Reliability analysis of transverse stability of surface ships

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NAVAL ENGINEERS JOURNAL 1997年第3期109卷 129-140页

作者： Atua, K Ayyub, BM Khaled l. Atua:is a graduate student at the Reliability Engi-neering Program at the University of Maryland at College Park. He completed his B.S. degree in naval architecture and marine engineering in 1988 and completed his M.S. degree in naval architecture and marine engineering in 1992 at Alexandtia University. He is also a visiting scholar in the Civil Engineering Department at the University ofMaryland at Colkge Park. He is conducting research with Dc Bilal M. Ayyub in the area of develupment of reliability-based design of ship structures and systems. He is a member ofASNE and SNAME. He has authored or coauthored several papers and reports. Bilal M. Ayyub: Ph.D. RE. is aprofssor of civil engineer-ing at the University of Maryland at College Park. He is also a researcher and consultant in the areas of structural engineering inspection methods and practices reliability and risk analysis. Dc Ayyub completed his B.S. degree in civil engineering in 1980 and completed both his M.S. (1981) and Ph.D. (1983) degrees in civil engineering at the Georgia Institute of Echnol-OD. Dc Ayyub has an extensive background in uncertainty modeling and analysis risk-based analysis and design simula-ion and marine structural reliability. He is engaged in research work involving structural reliability marine structures uncer-tainty modeling and analysis and mathematical modeling using the theories of probability statistics and fuzzy sets. He has completed several research projects that were funded by the National Science Foundation the U S. Coast Guard the U.S. Navy the U.S. Department of Defense the U.S. Army crops of Engineers the Maryland State Highway Administration the American Society ofMechanica1 Engineers and several engi-neering companies. Dc Ayyub served the engineering communio in various capacities through societies that include ASNE ASCE ASME SNAME IEEE-CS and NMIPS. He is a member ofthe ASME Research Committee of Risk Ethnology and the ASME Committee on Human Factors. Currently he is the chai

An introduction to a rational development of transverse stability criteria for surface ships is presented in this paper. The development is based on a probabilistic analysis of the uncertainties associated with the design parameters involved in determining the transverse stability. Reliability methods are used for assessing and determining transverse stability of ships. These reliability methods address the uncertainties associated with the basic design variables that are involved in stability assessment and design. The sources of uncertainty in stability variables are presented, uncertainties associated with these basic random variables are summarized, different reliability assessment methods are described, a case study that shows the computation procedure using some of these methods is discussed for illustration purposes, and finally, conclusions and recommendations for further work in this area are presented.

关键词： Naval vessels

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PARALLEL ANd dISTRIBUTEd TLM COMPUTATION WITH SIGNAL-PROCESSING FOR ELECTROMAGNETIC-FIELd MOdELING

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INTERNATIONAL JOURNAL OF NUMERICAL MOdELLING-ELECTRONIC NETWORKS dEVICES ANd FIELdS 1995年第3-4期8卷 169-185页

作者： SO, PPM ESWARAPPA, C HOEFER, WJR NSERC/MPR Teltech Research Chair in RF Engineering Department of Electrical and Computer Engineering University of Victoria Victoria British Columbia V8W 3P6 Canada Poman So received his B.Sc. degree in computer science and physics from the University of Toronto Toronto Onatario Canada in 1985. He obtained his B.A. Sc. and M.A.Sc. degrees in electrical engineering (summa cum laude) from the University of Ottawa Ottawa Ontario Canada in 1987 and 1989 respectively. Mr So was a research engineer in the University of Ottawa from January 1989 to October 1991 his research interests included CAD techniques of microwave circuits and numerical methods for electromagnetic wave modelling. He specialized in the development of electromagnetic engineering CAD software and successfully implemented a number of electromagnetic wave simulators based on the two-dimensional and three-dimensional transmission-line matrix methods. From August 1990 to February 1991 he accompanied Professor W. J. R. Hoefer to Rome Italy and Sophia Antiopolas France. During that time he implemented a parallel version of the 3D-TLM simulator for the CM-2 Connection Machine using C-Star and X Windows Library. He is a research engineer and a Ph.D. student at the University of Victoria Victoria British Columbia Canada. He ported the 2D- and 3D-TLM simulators to DECmpp 1200 massively parallel computer using MPL C and C++. He also combined OSA90/hope a commercially available microwave CAD program with a 2D-TLM simulation module for geometry optimization using the Datapipe technique of OSA90/hope. Recently he has developed a distributed client-server computing technique for the TLM method this technique could accelerate the TLM simulation by more than an order of magnitude. Channabasappa Eswarappa received the M.Tech. degree in electrical engineering from the Indian Institute of Technology Kanpur India in 1983 and Ph. D. degree from the University of Ottawa Canada in 1990. He worked as an Assistant Executive Engineer and later as

This paper describes the implementation of transmission-line matrix (TLM) method algorithms on a massively parallel computer (dECmpp 12000), the technique of distributed computing in the UNIX environment, and the combination of TLM analysis with Prony's method as well as with autoregressive moving average (ARMA) digital signal processing for electromagnetic field modelling. By combining these advanced computation techniques, typical electromagnetic field modelling of microwave structures by TLM analysis can be accelerated by a few orders of magnitude.

关键词： Mathematical models

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