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15th International Conference on Miniaturized systems for Chemistry and Life Sciences 2011, MicroTAS 2011

作者： Lee, Donghee Hyun, Ji-Chul Hong, Sung A. Yang, Sung Graduate-program of Medical System Engineering Korea Republic of School of Mechatronics Korea Republic of Department of Nanobio Materials and Electronics GIST Korea Republic of

ISBN: (纸本)9781618395955

In this study, a method to modify hydrophobic PDMS (Polydimethylsiloxane) surface to be long-lasting hydrophilic surface by applying atmospheric-pressure plasma polymerization is proposed. To enhance the sustainability of the modified hydrophilic PDMS, two kinds of plasma polymerized layers were implemented on the surface of the PDMS block sequentially. The highly cross-linked hydrocarbon layer deposited by atmospheric-pressure plasma polymerization from CH 4 plays a role as a physical barrier layer (PBL) to prevent hydrophobic recovery of the hydrophilic layer deposited from TEOS (Tetraethylorthosilicate) and O2. The modified PDMS surface shows long-lasting superhydrophilic wetting property over 28 days of aging time. Copyright © (2011) by the Chemical and Biological Microsystems Society.

关键词： Surface treatment

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Biomedical data and AI

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Science China Life Sciences 2025年第5期68卷 1536-1540页

作者： Hao Xu Shibo Zhou Zefeng Zhu Vincenzo Vitelli Liangyi Chen Ziwei Dai Ning Yang Luhua Lai Shengyong Yang Sergey Ovchinnikov Zhuoran Qiao Sirui Liu Chen Song Jianfeng Pei Han Wen Jianfeng Feng Yaoyao Zhang Zhengwei Xie Yang-Yu Liu Zhiyuan Li Fulai Jin Hao Li Mohammad Lotfollahi Xuegong Zhang Ge Yang Shihua Zhang Ge Gao Pulin Li Qi Liu Jing-Dong Jackie Han Peking-Tsinghua Center for Life Sciences (CLS) Academy for Advanced Interdisciplinary StudiesPeking University Center for Quantitative Biology (CQB) Academy for Advanced Interdisciplinary StudiesPeking University Peking University-Tsinghua University-National Institute of Biological Sciences Joint Graduate Program Academy for Advanced Interdisciplinary StudiesPeking University Department of Physics University of Chicago School of Life Sciences Southern University of Science and Technology Peking University Chengdu Academy for Advanced Interdisciplinary Biotechnologies College of Chemistry and Molecular Engineering Peking University Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan University Department of Biology Massachusetts Institute of Technology Lambic Therapeutics Inc. Changping Laboratory Al for Science Institute Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence Fudan University Department of Obstetrics and Gynecology West China Second University HospitalSichuan University Peking University International Cancer Institute and Peking University-Yunnan Baiyao International Medical Institute and State Key Laboratory of Natural and Biomimetic Drugs Department of Molecular and Cellular PharmacologySchool of Pharmaceutical SciencesPeking University Health Science CenterPeking University Channing Division of Network Medicine Department of MedicineBrigham and Women's Hospital and Harvard Medical School Center for Artificial Intelligence and Modeling the Carl R.Woese Institute for Genomic BiologyUniversity of Illinois Urbana-Champaign Department of Genetics and Genome Sciences School of Medicine and Department of Computer and Data Sciences and Department of Population and Quantitative Health SciencesCase Western Reserve University Department of Biochemistry and Biophysics University of California Sanger Institute Department of Automation Tsinghua University State Key Laboratory of Multimodal Artificial Intelligence Systems I

The development of artificial intelligence(AI) and the mining of biomedical data complement each other. From the direct use of computer vision results to analyze medical images for disease screening, to now integrating biological knowledge into models and even accelerating the development of new AI based on biological discoveries, the boundaries of both are constantly expanding, and their connections are becoming closer.

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Silica nanochannel device for pH sensing based on surface charge density changes

Silica nanochannel device for pH sensing based on surface ch...

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2010 10th IEEE Conference on Nanotechnology, NANO 2010

作者： Lee, Sang Young Yoon, Sang Youl Lee, Kyeong-Hwan Yang, Sung Department of Nanobio Material and Electronics School of Information and Mechatronics GIST Korea Republic of Graduate- Program of Medical System Engineering Biomedical Micro/Nano Device Laboratory GIST Korea Republic of

ISBN: (纸本)9781424470334

This paper demonstrates a novel micro/nano fluidic device for continuous pH sensing of small fluid volumes. The working principle of the device is based on the change of the surface charge density within the silica nano channels with respect to the pH levels of the electrolyte. In order to measure pH levels of various solutions, AC potential is applied along the silica nanochannels which have 50 nm depth, 2 μm width, and 30 μm length. The running current along the nanofluidic channels is directly measured with respect to pH levels. It was found that the running current is inversely proportional to pH levels regardless of ion concentrations. ©2010 IEEE.

关键词： Electrolytes

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A novel peristaltic micropump using three wings with different widths for fluid circulation

A novel peristaltic micropump using three wings with differe...

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14th International Conference on Miniaturized systems for Chemistry and Life Sciences 2010, MicroTAS 2010

作者： Mun, Byung Phil Park, Chang Ju Yoo, Sung Keun Lee, Jong Hyun School of Information and Mechatronics GIST Gwangju Korea Republic of Graduate Program of Medical System Engineering GIST Gwangju Korea Republic of Dept. of Nanobio Materials and Electronics GIST Gwangju Korea Republic of

ISBN: (纸本)9781618390622

This paper reports a novel micropump to effectively rotate fluid in a circular channel. The proposed micropump having different wing widths, which squeezes the flexible part of the fluidic channel at a different time interval, provides a peristaltic effect with a single pneumatic pressure source. This allows simple operation and easy integration with a micro total analysis system (μ-TAS).

关键词： Flexible structures

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Machine learning-based analysis on factors influencing blood heavy metal concentrations in the Korean CHildren's ENvironmental health Study (Ko-CHENS)

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Science of the Total Environment 2025年 978卷

作者： Jung, Seowoo Shah, Surabhi Oh, Jongmin Bang, Yoorim Lee, Ji Hyen Kim, Hwan-Cheol Jeong, Kyoung Sook Park, Huibyeol Lee, Eun-Kyung Hong, Yun-Chul Ha, Eunhee Department of Statistics Ewha Womans University Seoul Korea Republic of Department of Environmental Medicine College of Medicine Ewha Womans University Seoul Korea Republic of Department of Human Systems Medicine College of Medicine Seoul National University Seoul Korea Republic of College of Medicine Ewha Womans University Seoul Korea Republic of Institute for Development and Human Security Ewha Womans University Seoul Korea Republic of Department of Pediatrics College of Medicine Ewha Womans University Seoul Korea Republic of Department of Occupational and Environmental Medicine College of Medicine Inha University Hospital Inha University Incheon Korea Republic of Department of Occupational and Environmental Medicine Wonju College of Medicine Wonju Severance Christian Hospital Yonsei University Wonju Korea Republic of Environmental Health Research Division National Institute of Environmental Research Incheon Korea Republic of Institute of Environmental Medicine Medical Research Center Seoul National University Korea Republic of Graduate Program in System Health Science and Engineering Ewha Womans University Ewha Medical Research Institute College of Medicine Seoul Korea Republic of

Heavy metal concentration in pregnant women affects neurocognitive and behavioral development of their infants and children. The majority of existing research focusing on pregnant women's heavy metal concentration has considered individual environmental factor. In this study, we aim to comprehensively consider lifestyle, food, and environmental factors to determine the most influential factor affecting heavy metal concentration in pregnant women. The Ko-CHENS (Korean CHildren health and ENvironmental Study) is a nationwide prospective birth cohort study in South Korea enrolling pregnant women from 2015 to 2020. A total of 5458 eligible pregnant women were included in this study, and 897 variables were included in questionnaire comprising: maternal general information, indoor and living environment, dietary habits, health behavior, exposure to chemicals. Lead, cadmium and mercury concentration on blood were measured in early, late pregnancy and in cord blood at birth. Variables that might be related to heavy metal concentrations were included in machine learning models. Random forest and XGBoost machine learning models were conducted for predictions. Both models had similar but better performance than multiple linear regression. Kimchi (β = 1.55), seaweed (β = 0.40), fatty fish (β = 1.55), intakes respectively affected lead, cadmium, and mercury exposure through early, late pregnancy and cord blood. © 2025

关键词： Obstetrics

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Dual-color nonlinear optical microscope imaging and its applications

Dual-color nonlinear optical microscope imaging and its appl...

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2011 International Quantum Electronics Conference, IQEC 2011 and Conference on Lasers and Electro-Optics, CLEO Pacific Rim 2011

作者： Lee, Jang Hyuk Choi, Dae Sik Song, Dong Hoon Cho, Eun Hee Shin, Sang-Mo Oh, Myoung-Kyu Ko, Do-Kyeong Graduate Program of Photonics and Applied Physics Gwangju Institute of Science and Technology Gwangju 500-712 Korea Republic of Graduate Program of Medical System Engineering Gwangju Institute of Science and Technology Gwangju 500-712 Korea Republic of Advanced Photonics Research Institute Gwangju Institute of Science and Technology Gwangju 500-712 Korea Republic of

ISBN: (纸本)9780977565771

A photonic crystal fiber (PCF) based dual-color nonlinear microscope that combines coherent anti-Stokes Raman scattering (CARS) microscopy and two-photon excitation fluorescence (TPEF) microscopy was developed and applied to imaging of polystyrene beads, lily pollens, and live breast cancer cells using a femtosecond laser. © 2011 IEEE.

关键词： Photonic crystal fibers

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Contamination-free cell lysis microfluidic device using cell cross over

Contamination-free cell lysis microfluidic device using cell...

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13th International Conference on Miniaturized systems for Chemistry and Life Sciences, MicroTAS 2009

作者： Mun, Byung Phil Jung, Seung Mo Yoon, Sang Youl Lee, Jong Hyun Yang, Sung School of Information and Mechatronics Gwangju Institute of Science and Technology Korea Republic of Graduate Program of Medical System Engineering Gwangju Institute of Science and Technology Korea Republic of Department of Nanobio Materials and Electronics Gwangju Institute of Science and Technology Korea Republic of

ISBN: (纸本)9780979806421

Complicated and time-consuming cell purification processes prevent a micro cell lysis device from integrating with LOC (Lab-on-a-chip) or μ-TAS (μ-Total Analysis system) devices for cell analysis. In this paper, we present a microfluidic cell lysis device using a contamination-free cell cross over method in order to minimize the cell pretreatment procedure. © 2009 CBMS.

关键词： Microfluidics

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Ligand-exchange of TOPO-capped CdSe quantum dots with quinuclidines

Ligand-exchange of TOPO-capped CdSe quantum dots with quinuc...

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7th IEEE International Conference on Nano/Micro Engineered and Molecular systems, NEMS 2012

作者： Obliosca, Judy M. Tseng, Fan-Gang Huang, Ching-Mao Lo, Leu-Wei Wang, Pen-Cheng Department of Engineering and System Science National Tsing Hua University 101 Kuang-Fu Road Hsinchu 30013 Taiwan Taiwan International Graduate Program Institute of Physics Academia Sinica 128 Academia Road Nankang Taipei 11529 Taiwan Division of Medical Engineering Research National Health Research Institutes Zhunan 35053 Taiwan

ISBN: (纸本)9781467311243

A series of tertiary amine quinuclidine-capped cadmium selenide (Q-CdSe) quantum dots (QDs) of ∼4 nm in diameter was successfully synthesized via ligand exchange process in which the original hydrophobic trioctylphosphine oxide (TOPO) ligand bound to QDs was replaced with stronger quinuclidine derivatives, quinuclidine (Q1), 3-quinuclidinone (Q2) and 3-quinuclidinol (Q3). The ligand exchange of TOPO by Q probed using the combined fluorescence and absorption spectroscopy was achieved in just only a few minutes. Moreover, disappearance of prominent C-H aliphatic stretching (∼2900 cm-1) and phosphate signal (35 ppm) of TOPO-capped CdSe after replacement with Q as revealed in FT-IR and solid state 31P-NMR spectra was observed indicating efficient fast ligand exchange. © 2012 IEEE.

关键词： Cadmium compounds

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Selectively bonded polymeric check valve for the reliable regulation of intraocular pressure

Selectively bonded polymeric check valve for the reliable re...

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作者： Im, Seongmin Mun, Byungphil An, Jaeyong Choi, Jongchan Yang, Sung Lee, Jonghyun School of Mechatronics Gwangju Institute of Science and Technology Gwangju Korea Republic of Graduate Program of Medical System Engineering Gwangju Institute of Science and Technology Gwangju Korea Republic of Department of Nanobio Materials and Electronics Gwangju Institute of Science and Technology Gwangju Korea Republic of

ISBN: (纸本)9789898425379

A glaucoma drainage device for the regulation of intraocular pressure is presented. The device consists of three biocompatible polymer layers: the cover (top layer), the diaphragm (intermediate layer), and the baseplate with a cannular (bottom layer). Finite element analyses (FEA) were performed to find optimal design parameters for the targeted cracking pressure: the diameter of orifice, the thickness of intermediate layer, the width of the channel, and the overlapped length of the orifice over valve seat. Top and bottom layers were made by polydimethylsiloxane (PDMS) replica molding process, and an intermediate thin layer with through-holes was fabricated by PDMS fill-in molding method and hydrophobic treatment. The overlapped area of the bottom layer was coated with Cr and Au by using PDMS as a shadow mask. Metal layers are not to be bonded between the bottom and the intermediate layers so that the device showed the enhanced reliability in operation and the higher yield in production. Oxygen plasma treatment was performed for irreversible bonds between separate three PDMS layers. The experimental cracking pressure of the fabricated valve was 2.50 kPa, which is very close to the target value (2.67 kPa). The experiments showed that the proposed polymer check valve can regulate the pressure of the aqueous humour, fluid in an anterior chamber, within the normal intraocular pressure range (15-20mmHg) with a high repeatability.

关键词： Polydimethylsiloxane

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A microassembly process to realize angular vertical comb electrodes for a gimbal-less two-axis electrostatic scanner

A microassembly process to realize angular vertical comb ele...

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IEEE International Conference on Micro Electro Mechanical systems

作者： Min-Ho Jun Seunghwan Moon Jong-Hyun Lee Graduate School of Information and Mechatronics Gwangju Institute of Science and Technology Gwangju South Korea Graduate-program of Medical System Engineering Gwangju Institute of Science and Technology Gwangju South Korea

This paper proposes a microassembly process that easily realizes a gimbal-less two-axis electrostatic MEMS scanner with fixed angular vertical comb electrodes (FAVCs). The fabrication steps can be remarkably reduced by employing a microassembly, as there is no need to add an insulation layer and conduct a multi-step etching process for SVCs. The reduction in the number of fabrication steps also improves the device yield and reduces fabrication errors. The proposed scanner can be readily applied to various optical applications, as the slow axis is driven by quasi-static operation, allowing the amplitude of the scanning angle to remain constant within a specific frequency range.

关键词： Microassembly Springs Electrostatics Silicon Optical device fabrication Mirrors

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