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Nutrients deprivation of biomimetic nanozymes for cascade catalysis triggered and oxidative damage induced tumor eradication

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Chinese Chemical Letters 2025年第3期36卷 351-356页

作者： Yingtao Zhong Ziwen Qiu Yanmei Li Jiaqi Huang Zhenming Lu Renjiang Kong Ni Yan Hong Cheng School of Biomedical Engineering&Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering Southern Medical UniversityGuangzhou 510515China

Deprivation of glucose and lactate provides an effective pathway to terminate the nutrients supplement for tumor *** this work,biomimetic nanozymes called m@BGLC are constructed for catalytic tumor inhibition through nutrients deprivation and oxidative damage ***,the catalytic enzymes of glucose oxidase(GOx),lactate oxidase(LOx)and chloroperoxidase(CPO)are precrosslinked with bovine serum albumin(BSA)to construct nanozymes,which are then biomimetic functionalized with cancer cell membrane to prepare m@*** from the biomimetic camouflage with homologous cell membrane,m@BGLC inherit homotypic binding and immune escape abilities,facilitating the tumor targeting accumulation and preferable cell internalization for improved drug delivery ***,under the cascade catalysis of nanozymes,m@BGLC consume glucose and lactate for tumor starvation therapy through nutrients deprivation,and meanwhile,the resulting hyprochloric acid(HClO)causes an oxidative damage of cells to synergistically inhibit tumor *** vitro and in vivo findings demonstrate a robust tumor eradication effect of m@BGLC without obvious adverse reactions via the targeted combination *** cascade catalytic nanomedicine may inspire the development of sophisticated strategies for tumor combination therapy under unfavorable tumor microenvironments.

关键词： Biomimetic nanozymes Cascade catalysis Nutrients deprivation Starvation therapy Oxidative damage

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Feedback enhanced tumor targeting delivery of albumin-based nanomedicine to amplify photodynamic therapy by regulating AMPK signaling and inhibiting GSTs

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Chinese Chemical Letters 2024年第8期35卷 481-485页

作者： Jiaqi Huang Renjiang Kong Yanmei Li Ni Yan Yeyang Wu Ziwen Qiu Zhenming Lu Xiaona Rao Shiying Li Hong Cheng School of Biomedical Engineering&Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering Southern Medical UniversityGuangzhou 510515China School of Pharmaceutical Sciences Guangzhou Medical UniversityGuangzhou 511436China

Oxidative therapies receive a limited antitumor efficiency due to the insufficient reactive oxygen species(ROS)levels at focal sites and the evolvement of antioxidant defense ***,we develop an albumin-based nanomedicine to co-deliver chlorin e6(Ce6)and COH-SR4(CS),which can simultaneously enhance the yield and lethality of intracellular ROS for amplified photodynamic therapy(PDT).In which,CS acts as both an activator of AMP-activated protein kinase(AMPK)and an inhibitor of glutathione S-transferases(GSTs).Benefiting from it,the prepared HSA-Ce6@COH-SR4(HCCS)enables positive feed-back uptake by promoting AMPK phosphorylation,leading to rapid and extensive tumor accumulation of *** a result,HCCS obviously increases the ROS production to elevate intracellular oxidative ***,HCCS can inhibit GSTs to disturb the antioxidant defense system of tumor cells,intensifying the oxidative damage of ***,the PDT of HCCS is significantly strengthened by improving the ROS yield and lethality,which greatly declines the proliferation of breast cancer in *** study may open a window in the development of drug co-delivery system for enhanced oxidative therapy of tumors.

关键词： Human serum albumin Drug delivery Reactive oxygen species Positive feedback uptake Oxidative damage

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Cardiac-Adaptive Conductive Hydrogel Patch Enabling construction of Mechanical–Electrical Anisotropic Microenvironment for Heart Repair

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Research 2024年第1期2023卷 489-507页

作者： Xiaoping Song Jifeng Zhang Si Shen Dan Liu Jie Zhang Wenming Yin Genlan Ye Leyu Wang Liu Cai Honghao Hou Xiaozhong Qiu Central Laboratory The Fifth Affiliated HospitalSouthern Medical UniversityGuangzhouGuangdong 510910China Department of Anatomy Neuroscience Laboratory for Cognitive and Developmental DisordersMedical College of Jinan UniversityGuangzhou 510630China Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering School of Basic Medical ScienceBiomaterials Research CenterSchool of Biomedical EngineeringSouthern Medical UniversityGuangzhouGuangdong 510515China

The biomimetic construction of a microstructural–mechanical–electrical anisotropic microenvironment adaptive to the native cardiac tissue is essential to repair myocardial infarction(MI).Inspired by the 3D anisotropic characteristic of the natural fish swim bladder(FSB),a novel flexible,anisotropic,and conductive hydrogel was developed for tissue-specific adaptation to the anisotropic structural,conductive,and mechanical features of the native cardiac extracellular *** results revealed that the originally stiff,homogeneous FSB film was tailored to a highly flexible anisotropic hydrogel,enabling its potential as a functional engineered cardiac patch(ECP).In vitro and in vivo experiments demonstrated the enhanced electrophysiological activity,maturation,elongation,and orientation of cardiomyocytes(CMs),and marked MI repair performance with reduced CM apoptosis and myocardial fibrosis,thereby promoting cell retention,myogenesis,and vascularization,as well as improving electrical *** findings offer a potential strategy for functional ECP and provides a novel strategy to bionically simulate the complex cardiac repair environment.

关键词： bladder thereby patch

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The cardiac electrophysiology-inspired patches for repairing myocardial infarction: A review

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Smart Materials in Medicine 2025年第1期6卷 108-119页

作者： Zhang, Songtao Shao, Ziyi Wu, Yihong Song, Yongyi He, Yaxi Liu, Zongyi Fu, Xiaodong Wang, Leyu Department of Neurology Institute of Neuroscience Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China The Second Affiliated Hospital Guangzhou Medical University Guangzhou510260 China Department of Cardiology Guangzhou Institute of Cardiovascular Disease Guangdong Key Laboratory of Vascular Diseases The Second Affiliated Hospital Guangzhou Medical University Guangzhou510260 China Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering Biomaterials Research Center School of Biomedical Engineering Southern Medical University Guangzhou510515 China

Myocardial infarction has been a serious threat to human health due to its high morbidity and mortality all over the world. The major problem is the loss of limited regenerative cardiomyocytes and occurrence of inflammatory response, leading to the formation of non-contractile and non-conducting fibrotic scar tissue. Thus, it disrupts the mechano-electric coupling system of the heart, negatively influencing the heart function. Recently, the conductive cardiac patches with advantage of reconstructing electrical propagation have been extensively applied for cardiac repair. This review introduces a detailed overview of the recent progress in cardiac electrophysiology-inspired patches for cardiac repair from three parts of the construction and functionality of mechano-electric coupling cardiac patches, the construction and functionality of microstructure of the cardiac patches, the realtime detection based on mechano-electric transformation. Finally, the achievements and future perspective of conductive cardiac patches is discussed from the aspects of biosafety, further exploration of factors affecting mechano-electric coupling in cardiac patches and regulation of detection. It is hopeful to help researchers understand the functional components and development of conductive cardiac patches for cardiac repair, as well as to inspire them to synthesize novel cardiac patches for promoting clinical translation. © 2025 The Authors

关键词： Electrophysiology

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Ce6-GFFY is a novel photosensitizer for colorectal cancer therapy

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Genes & Diseases 2025年第2期12卷 304-318页

作者： Wei Qiao Shuxin Li Linna Luo Meiling Chen Xiaobin Zheng Jiacong Ye Zhaohui Liang Qiaoli Wang Ting Hu Ling Zhou Jing Wang Xiaosong Ge Guokai Feng Fang Hu Rongbin Liu Jianjun Li Jie Yang Department of Endoscopy State Key Laboratory of Oncology in South ChinaGuangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhouGuangdong 510060China State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhouGuangdong 510060China Department of Nuclear Medicine State Key Laboratory of Oncology in South ChinaGuangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhouGuangdong 510060China Department of Oncology Affliated Hospital of Jiangnan UniversityWuxiJiangsu 214062China Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering Biomaterials Research CenterSchool of Biomedical EngineeringSouthern Medical UniversityGuangzhouGuangdong 510515China Department of Ultrasound Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouGuangdong 510120China Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yatsen Memorial HospitalSun Yat-Sen UniversityGuangzhouGuangdong 510120China

Photodynamic therapy is an"old"strategy for cancer therapy featuring clinical safety and rapid working,but suitable photosensitizers for colorectal cancer therapy remain *** study synthesized a novel photosensitizer termed Ce6-GFFY based on a self-assembling peptide GFFY and a photo-responsive molecule chlorin e6(Ce6).Ce6-GFFY forms macroparticles with a diameter of~160 nm and possesses a half-life of 10 h,as well as an ideal tumor-targeting ability in mouse ***6-GFFY effectively penetrates cells and generates numerous reactive oxygen species upon 660 nm laser *** reactive oxygen species promotes the accumulation of cytotoxic T cells and decrease of myeloid-derived suppressor cells in the tumor microenvironment through immunogenic cell death,thus prohibiting the growth of both primary and metastatic tumors after once *** study not only provides a strategy for photosensitizer development but also confirms a promising application of Ce6-GFFY for colorectal cancer therapy.

关键词： Anti-tumorimmunity Ce6-GFFY Colorectal cancer Novel photosensitizer Photodynamic therapy

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Biomimetic microstructural scaffolds and their applications in tissue engineering

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Biomedical engineering Communications 2022年第1期1卷 36-48页

作者： Ru-Rong Lin Cheng Chen Hai-Bin Zheng Chun-Yi Pu Jian-Xing Huang Qi-Xiang Duan Shuai Liu Xiao-Zhong Qiu Hong-Hao Hou Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering School of Basic Medical ScienceSouthern Medical UniversityGuangdongGuangzhou 510515China

The dynamic structures of extracellular matrix regulate cell behaviors by providing three-dimension ecological niche and mechanical *** the progress of both surface patterning and biomaterials,the cues of micro-and nanoscale topography on microstructural scaffold biomaterials are increasingly recognized as decisive factors of biomimetic *** this review,we provide an overview of the recent progress of biomimetic microstructured scaffolds,including advances in their biomimetic manufacturing technology,functionality,potential applications and future *** highlight recent progress in the fabrication of microstructured scaffold materials with various biological and physicochemical characteristics of native extracellular *** recent key advances of microstructured scaffold for tissue engineering,bio-adhesive,antibacterial and biosensing applications were ***,we summarize by offering our perspective on this fast-growing field.

关键词： tissue engineering biomimetic scaffold microstructure bio-adhesive antibacterial biosensing

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A bioactive glass functional hydrogel enhances bone augmentation via synergistic angiogenesis,self-swelling and osteogenesis

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Bioactive Materials 2023年第4期22卷 201-210页

作者： Fujian Zhao Zhen Yang Huacui Xiong Yang Yan Xiaofeng Chen Longquan Shao Stomatological Hospital Southern Medical UniversityGuangzhou510280China Department of Biomedical Engineering School of Materials Science and EngineeringSouth China University of TechnologyGuangzhou510641China National Engineering Research Center for Tissue Restoration and Reconstruction South China University of TechnologyGuangzhou510006China Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering Guangzhou510515China

Bone augmentation materials usually cannot provide enough new bone for dental implants due to the material degradation and mucosal *** use of hydrogels with self-swelling properties may provide a higher bone augmentation,although swelling is generally considered to be a disadvantage in tissue ***,a double-crosslinked gelatin-hyaluronic acid hydrogels(GH)with self-swelling properties were ***,niobium doped bioactive glasses(NbBG)was dispersed in the hydrogel network to prepare the GH-NbBG *** composite hydrogel exhibited excellent biocompatibility and the addition of NbBG significantly improved the mechanical properties of the *** vivo results found that GH-NbBG synergistically promoted angiogenesis and increased bone augmentation by self-swelling at the early stage of *** addition,at the late stage after implantation,GH-NbBG significantly promoted new bone formation by activating RUNX2/Bglap signaling ***,this study reverses the self-swelling disadvantage of hydrogels into advantage and provides novel ideas for the application of hydrogels in bone augmentation.

关键词： Bioactive glass Bone formation Osteogenesis Angiogenesis

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A cigarette filter-derived biomimetic cardiac niche for myocardial infarction repair

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Bioactive Materials 2024年第5期35卷 362-381页

作者： Guofeng Tang Zhentao Li Chengbin Ding Jiang Zhao Xianglong Xing Yan Sun Xiaozhong Qiu Leyu Wang Biomaterials Research Center School of Biomedical EngineeringSouthern Medical UniversityGuangzhouGuangdong510515PR China Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering Southern Medical UniversityGuangzhouGuangdong510515PR China School of Basic Medical Science Southern Medical UniversityGuangzhouGuangdong510515PR China Thoracic and Cardiovascular Surgery The Tenth Affiliated HospitalSouthern Medical University(Dongguan People’s Hospital)DongguanGuangdong523058PR China

Cell implantation offers an appealing avenue for heart repair after myocardial infarction(MI).Nevertheless,the implanted cells are subjected to the aberrant myocardial niche,which inhibits cell survival and maturation,posing significant challenges to the ultimate therapeutic *** functional cardiac patches(CPs)have been proved to construct an elastic conductive,antioxidative,and angiogenic microenvironment for rectifying the aberrant microenvironment of the infarcted *** importantly,inducing implanted cardiomyocytes(CMs)adapted to the anisotropic arrangement of myocardial tissue by bioengineered structural cues within CPs are more conducive to MI ***,a functional Cig/(TA-Cu)CP served as biomimetic cardiac niche was fabricated based on structural anisotropic cigarette filter by modifying with tannic acid(TA)-chelated Cu2+(TA-Cu complex)via a green *** CP possessed microstructural anisotropy,electrical conductivity and mechanical properties similar to natural myocardium,which could promote elongation,orientation,maturation,and functionalization of ***,the Cig/(TA-Cu)CP could efficiently scavenge reactive oxygen species,reduce CM apoptosis,ultimately facilitating myocardial electrical integration,promoting vascular regeneration and improving cardiac ***,our study introduces a functional CP that integrates multimodal cues to create a biomimetic cardiac niche and provides an effective strategy for cardiac repair.

关键词： Cigarette filter Cardiac patch Myocardial infarction Structural anisotropy Antioxidative Angiogenic

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Recent advances in nano material-based application of liver neoplasms

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Smart Materials in Medicine 2021年 2卷 114-123页

作者： Cao, Yuan Zhang, Hong-Wu Department of Anatomy Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering Southern Medical University China

Significant impacts have occurred around the world because of liver neoplasms, especially Hepatocellular Carcinoma(HCC). Nano material has been used in diagnosis and treatment of liver neoplasms and showed us the productive prospect. This paper summarizes the classical theoretical basis for the application of liver cancer based on nano materials, such as passive targeted conveying and active targeted conveying. Then we review the detailed application directions of nano materials in recent years, and discusses the corresponding conditions of nano particles in detail. Finally, we introduced some hopeful derection of nano materials in liver neoplasm such as oligonucleotide-therapy carrier and nano particles therapy. © 2021

关键词： Conveying

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Bioactive matters based on natural product for cardiovascular diseases

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Smart Materials in Medicine 2024年第4期5卷 542-565页

作者： Zhong, Linfang Tan, Xiaoying Yang, Wenhui Li, Peishan Ye, Lianbao Luo, Qi Hou, Honghao The Fifth Affiliated Hospital Southern Medical University Guangzhou510900 China School of Traditional Chinese Medicine Southern Medical University Guangzhou510515 China Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering School of Basic Medical Science Southern Medical University Guangzhou510515 China School of Pharmacy Guangdong Pharmaceutical University Guangzhou510006 China

Natural products are valuable sources of bioactive compounds for drug development. It is useful to explore natural products to treat cardiovascular disease. This review provides an overview of the natural products, including their general sources, structure types, functional methods, applications for cardiovascular diseases and future challenges. We highlight recent advances in drug delivery systems of natural products applicated in cardiovascular diseases such as nanoparticles, microspheres and hydrogels, and outline general strategies for functionalizing the natural product with various biological. Finally, we propose our perspective on challenges and future developments in this rapidly-evolving field. © 2024 The Authors

关键词： Natural product Bioactive matters Cardiovascular diseases Natural-product-loading biomaterials Synthesis of natural product

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