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SSRN 2023年

作者： Xiao, Li Lu, Zheng Zhao, Xuewei Feng, Yang Zhao, Ruixia Qiu, Zuchun Chen, Wei Nie, Guochao Cao, Huiling Hou, Yingchun College of Life Sciences Shaanxi Normal University Xi’an710119 China Xi’an Key Laboratory of Basic and Translation of Cardiovascular Metabolic Disease College of Pharmacy Xi’an Medical University Xi’an710021 China Department of Physics Guangxi Colleges and Universities Key Lab of Complex System Optimization and Big Data Processing Yulin Normal University Guangxi Yulin537000 China

Current chemotherapeutic efficacy is limited by the fast acquisition of multidrug resistance (MDR) with high side effects. In this study, 66 MDR-relevant hub genes in hepatocellular carcinoma (HCC) were identified by the combined analysis of differential expressed genes (DEGs), gene functional enrichment, Cox proportional regression, weighted gene co-expression network analysis (WGCNA) and protein-protein interaction (PPI) network construction. The prognostic risk models were established via the LASSO-Cox regression analysis. Based on the comparison of gene mutation frequency, tumor mutation burden (TMB) and immune infiltration in the high and low-risk groups, the relationships between the MDR-relevant hub genes and immune regulation were explored. The competitive endogenous RNA (ceRNA) networks of MDR-relevant hub genes and relevant non-coding RNAs (ncRNAs) were predicted and concluded to explore the potential mechanisms. Five MDR-relevant hub genes in drug-resistant HCC were finally confirmed, including ATP-binding cassette subfamily B member 6 (ABCB6), filamin C (FLNC), mutated in colorectal cancer (MCC), neuron navigator 3 (NAV3) and tripartite motif containing 9 (TRIM9). TRIM9 was identified as the most significant gene enhancing MDR, and its inhibition caused the IC50 of doxorubicin (DOX) decreased, and the intracellular uptake, retention and absorption of DOX increased significantly in HepG2/ADR cells. The results above may provide new insights into the mechanism of MDR development. With further exploration in future, the MDR-relevant hub genes, especially TRIM9 may be therapeutically targeted to improve the prognosis of drug-resistant HCC patients. © 2023, The Authors. All rights reserved.

关键词： Genes

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NONSMOOTH INTERVAL-VALUED MULTIOBJECTIVE optimization PROBLEMS AND GENERALIZED VARIATIONAL INEQUALITIES ON HADAMARD MANIFOLDS

Applied Set-Valued Analysis and Optimization

引用

Applied Set-Valued Analysis and optimization 2023年第1期5卷 69-84页

作者： Upadhyay, B.B. Li, Lijie Mishra, Priyanka Department of Mathematics Indian Institute of Technology Patna Bihar Patna801103 India Guangxi Colleges Universities Key Laboratory of Complex System Optimization and Big Data Processing Yulin Normal University Guangxi Yulin537000 China Mathematics Division School of Advanced Sciences and Languages VIT Bhopal University Bhopal-Indore Highway Kothrikalan Madhya Pradesh Sehore466114 India

In this paper, we study the classes of approximate Minty and Stampacchia type vector variational inequalities along with their local and weak versions on a Hadamard manifold, and a class of nonsmooth interval-valued multiobjective optimization problems, respectively. We obtain the equivalence between the solutions of considered approximate vector variational inequalities and LU-efficient solutions of nonsmooth interval-valued multiobjective optimization problems in which the cost function is assumed to be geodesic approximately LU-convex or geodesic LU-α-convex. ©2023 Applied Set-Valued Analysis and optimization.

关键词： Cost functions

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Analysis of drying characteristics and quality of Star Anise (Illicium verum) using microwave vacuum and hot air combined drying

Journal of Biotech Research

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Journal of Biotech Research 2023年 15卷 386-396页

作者： Liu, Yongfu Zhou, Xiaoting Pan, Xiaoli Fan, Wenyan Yang, Guimei Yu, Wangxin Hong, Weisheng School of Physical and Telecommunication Engineering Yulin Normal University Guangxi Yulin China Yulin Center for Food and Drug Control Guangxi Yulin China Guangxi Colleges and Universities Key Lab of Complex System Optimization and Big Data Processing Yulin Normal University Guangxi Yulin China Center for Applied Mathematics of Guangxi Yulin Normal University Guangxi Yulin China Fangchenggang Agricultural Machinery Service Center Guangxi Fangchenggang China

Star anise, rich in effective active constituents, is extensively employed in the pharmaceutical and food industries. The drying temperature can irreversibly damage these constituents. To enhance the drying quality and efficiency, this study undertook experiments using three drying methods on star anise including microwave vacuum drying, hot air drying, and a combination of microwave vacuum and hot air drying. The research examined the impacts of varying drying conditions on the drying characteristics of star anise, the moisture diffusion coefficient, and the primary component contents (anethole and shikimic acid). Models were separately established for microwave vacuum and hot air thin-layer drying kinetics including Lewis, Weibull distribution, two-term exponential, Wang, and Singh models, and a Weibull distribution model for combined microwave vacuum-hot air drying. The results indicated that drying with microwave vacuum and hot air primarily proceeded in a falling rate drying phase, whereas combined microwave vacuum and hot air drying encompassed both falling rate and constant rate stages. The effective moisture diffusion coefficients (Deff) for microwave vacuum drying and hot air drying of star anise ranged from 3.4423E-07 to 8.8239E-07 m2/s and 2.0386E-08 to 8.8239E-07 m2/s, respectively, while the Deff for combined microwave and hot air drying ranged from 2.8683E-07 to 4.8014E-07 m2/s and 7.9516E-8 to 2.0964E-7 m2/s, respectively. Evidently, segmented combined drying facilitated more convenient moisture diffusion, and both coefficients increased with microwave power and hot air temperature. During the microwave vacuum and hot air drying processes, both the Wang and Singh models and the Weibull distribution models showed good fitting effects. The Weibull distribution model could effectively predict the drying behavior of segmented microwave vacuum and hot air drying of star anise. In comparison with hot air drying time, combined microwave vacuum and hot air dr

关键词： Drying

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FRACTIONAL PARTIAL DIFFERENTIAL VARIATIONAL INEQUALITY

arXiv

引用

arXiv 2023年

作者： Cen, Jinxia Sousa, Vanterler Da C.J. Wu, Wei School of Mathematical Sciences Zhejiang Normal University Jinhua321004 China Aerospace Engineering PPGEA-UEMA Department of Mathematics DEMATIUEMA MA Sao Luís65054 Brazil Center for Applied Mathematics of Guangxi Guangxi Colleges Universities Key Laboratory of Complex System Optimization and Big Data Processing Yulin Normal University Guangxi Yulin537000 China

In this present paper, we introduce and study a dynamical systems involving fractional derivative operator and nonlocal condition, which is constituted of a fractional evolution equation and a time-dependent variational inequality, and is named as fractional partial differential variational inequality (FPDVI, for short). By employing the estimates involving the one-and two-parameter Mittag-Leffler functions, fixed-point theory for set-value mappings, and non-compactness measure theory, we develop a general framework to establish the existence of smooth solutions to (FPDVI).MSC Codes 47J20, 35R11, 49J40, 35J88, 26A33 Copyright © 2023, The Authors. All rights reserved.

关键词： Dynamical systems

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Drying kinetics characteristics and model fitting of exocarpium citreic grandis microwave vacuum drying

Journal of Biotech Research

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Journal of Biotech Research 2023年 15卷 397-409页

作者： Zhou, Ying Liu, Yongfu Liu, Jiaming Pan, Xiaoli Yang, Guimei Lv, Weiwei Li, Weibin Yulin Center for Food and Drug Control Guangxi Yulin China School of Physical and Telecommunication Engineering China Guangxi Colleges and Universities Key Lab of Complex System Optimization and Big Data Processing China Center for Applied Mathematics of Guangxi Yulin Normal University Guangxi Yulin China Fangchenggang Agricultural Machinery Service Center Guangxi Fangchenggang China Yulin City Food and Drug Certification Evaluation Center Guangxi Yulin China

Exocarpium citreic grandis is the immature outer peel of grapefruit and contains active ingredients such as naringin and rhoifolin. The drying temperature can have a significant effect on the constituents. In order to explore the rules of moisture and quality changes in exocarpium citreic grandis during microwave vacuum drying, this study investigated the effects of different microwave intensities (0.75, 1.25, 1.50, 1.75, 2.00 W/g) on the drying characteristics and main component content of exocarpium citreic grandis. The results showed that, at a microwave intensity of 0.75 W/g, the drying process was controlled by a constant speed stage. At microwave intensities of 1.25 W/g and 1.50 W/g, the drying process was divided into three parts including acceleration stage, constant speed stage, and deceleration stage. When the microwave intensity increased to 1.75 W/g and 2.00 W/g, the drying process was divided into acceleration and deceleration stages with no constant speed drying stage. The resulted data suggested that the thin-layer drying kinetics model of exocarpium citreic grandis was fitted. The selection principle of the model was analyzed from four aspects including modification of the original model, transformation of dependent and independent variables, complex model, and initial and terminal conditions. Lewis, Page, Two-term exponential, and Weibull distribution models were selected for fitting analysis. The optimal thin-layer drying models were the Page model and the Weibull distribution model. The scale parameter α of the Weibull distribution function decreased with the increase in microwave intensity. The shape parameter β underwent slight changes with moisture migration mechanisms being the combined effect of surface moisture evaporation and internal moisture diffusion. The effective moisture diffusion coefficient Deff was increasing with the increase in microwave intensity. The activation energy Ea for microwave vacuum drying of exocarpium citreic grandis

关键词： Weibull distribution

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BLOWN: A Blockchain Protocol for Single-Hop Wireless Networks under Adversarial SINR

arXiv

引用

arXiv 2021年

作者： Xu, Minghui Zhao, Feng Zou, Yifei Liu, Chunchi Cheng, Xiuzhen Dressler, Falko The School of Computer Science and Technology Shandong University Qingdao266510 China The Guangxi Colleges and Universities Key Laboratory of Complex System Optimization and Big Data Processing Yulin Normal University Yulin China Ernst & Young Shanghai200120 China The School of Electrical Engineering and Computer Science TU Berlin Berlin10587 Germany

Known as a distributed ledger technology (DLT), blockchain has attracted much attention due to its properties such as decentralization, security, immutability and transparency, and its potential of servicing as an infrastructure for various applications. Blockchain can empower wireless networks with identity management, data integrity, access control, and high-level security. However, previous studies on blockchain-enabled wireless networks mostly focus on proposing architectures or building systems with popular blockchain protocols. Nevertheless, such existing protocols have obvious shortcomings when adopted in wireless networks where nodes may have limited physical resources, may fall short of well-established reliable channels, or may suffer from variable bandwidths impacted by environments or jamming attacks. In this paper, we propose a novel consensus protocol named Proof-of-Channel (PoC) leveraging the natural properties of wireless communications, and develop a permissioned BLOWN protocol (BLOckchain protocol for Wireless Networks) for single-hop wireless networks under an adversarial SINR model. We formalize BLOWN with the universal composition framework and prove its security properties, namely persistence and liveness, as well as its strengths in countering against adversarial jamming, double-spending, and Sybil attacks, which are also demonstrated by extensive simulation studies. Copyright © 2021, The Authors. All rights reserved.

关键词： Blockchain

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Wideband polarization reconfigurable antenna based on double C-shaped radiators

Wideband polarization reconfigurable antenna based on double...

引用

International Applied Computational Electromagnetics Society Symposium (ACES)

作者： Weilong Liang Long Li Zhao Wu Yanhu Huang Qingxiu Ma Jiajun Liang Nanjing Research Institute of Electronics Technology Nanjing P. R. China School of Physics and Telecommunication Engineering Yulin Normal University Yulin P. R. China Guangxi Colleges and Universities Key Lab of Complex System Optimization and Big Data Processing Yulin Normal University Yulin P. R. China

An enhancing bandwidth tri-polarization reconfigurable antenna based on double C-shaped radiators is proposed. The antenna consists of a modified ground plane, double C-shaped radiators, and a feedline with a simple parasitic stub. The modified ground plane and the parasitic stub can improve the impedance matching, meanwhile, adjust the axial ratio performance. Two PIN diodes are embedded between the C-shaped radiator and the feedline. Three polarization reconfigurable modes can be achieved caused by switching two PIN diodes state, linear polarization (LP), left-hand circular polarization (LHCP), and right-hand circular polarization (RHCP). As the simulated results show, the −10-dB impedance bandwidth reaches 126.6% (1.76-7.83 GHz) in LP mode and 78.4% (2.96-6.78 GHz) in CP modes. And the proposed antenna has a 3-dB axial ratio (AR) bandwidth of 84% (2.6-6.4 GHz) in two CP modes. Therefore, the proposed antenna can meet the requirement of the modern wireless and satellite communication system.

关键词： Wireless communication Polarization Satellite antennas PIN photodiodes Switches Antenna feeds Broadband antennas

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RETRACTED ARTICLE: Research on North Gulf distributed big data submarine 3D terrain computing system based on remote sensing and multi-beam

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Soft Computing 2019年第8期24卷 5847-5857页

作者： Dong, Yuan Hu, BaoQing Zhang, ShiLun Huang, YuanLin Nong, GuoCai Xin, Han College of Resource and Environment Beibu Gulf University Qinzhou People’s Republic of China Guangxi Colleges and Universities Key Laboratory of Complex System Optimization and Big Data Processing Yulin Normal University Yulin People’s Republic of China The Key Laboratory for Advanced Technology to Internet of Things Beibu Gulf University Qinzhou China Key Laboratory of Environment Evolution and Resources Utilization in Beibu Gulf (Nanning Teachers Education University) Ministry of Education Nanning People’s Republic of China

North Gulf is China’s important sea route to Asia and Europe, and the seabed is rich in resources. For various reasons, the detection and mapping of submarine terrain are blank. The traditional multi-beam measurement method has high accuracy but uneven spatial distribution. Although the detection line process has high sampling and measurement accuracy, there is a large blank area between adjacent routes, which is difficult to achieve full-scale large area measurement due to environmental, time and budget constraints. On the other hand, the accuracy of the remote sensing inversion depth method is not high, but it can achieve a wide range of coverage, which is characterized by low cost, short cycle and convenient dynamic monitoring. This paper takes North Gulf as the research area, uses remote sensing data to construct the seabed topography, uses multi-beam data for checksum correction and uses distributed computing technology to distribute big data in different computing nodes, and the data are refined and reconstructed in three dimensions to form a 3D seabed topography. The method improves the efficiency and accuracy of multi-beam data processing and can construct a large area, high-resolution submarine DEM and realize database management.

关键词：

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A new class of history-dependent quasi variational-hemivariational inequalities with constraints

arXiv

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arXiv 2023年

作者： Migórski, Stanislaw Bai, Yunru Zeng, Shengda College of Applied Mathematics Chengdu University of Information Technology Sichuan Province Chengdu610225 China School of Science Guangxi University of Science and Technology Guangxi Province Liuzhou545006 China Jagiellonian University in Krakow Faculty of Mathematics and Computer Science ul. Lojasiewicza 6 Krakow30348 Poland Guangxi Colleges and Universities Key Laboratory of Complex System Optimization and Big Data Processing Yulin Normal University Guangxi Province Yulin537000 China

In this paper we consider an abstract class of time-dependent quasi variational-hemivariational inequalities which involves history-dependent operators and a set of unilateral constraints. First, we establish the existence and uniqueness of solution by using a recent result for elliptic variational-hemivariational inequalities in reflexive Banach spaces combined with a fixed-point principle for history-dependent operators. Then, we apply the abstract result to show the unique weak solvability to a quasistatic viscoelastic frictional contact problem. The contact law involves a unilateral Signorini-type condition for the normal velocity and the nonmonotone normal damped response condition while the friction condition is a version of the Coulomb law of dry friction in which the friction bound depends on the accumulated *** Codes 35J87, 47J20, 49J40, 49J45, 74G30, 74M15 © 2023, CC BY.

关键词： Friction

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On second order differential inclusion driven by quasi-variational–hemivariational inequalities

引用

Nonlinear Analysis: Real World Applications 2024年 77卷

作者： Liang, Yunshui Ceng, Lu-Chuan Yao, Jen-Chih Zeng, Shengda Department of Mathematics Shanghai Normal University Shanghai200234 China Center for Fundamental Science Kaohsiung Medical University Kaohsiung807 Taiwan Department of Applied Mathematics National Sun Yat-sen University Kaohsiung804 Taiwan Center for Applied Mathematics of Guangxi and Guangxi Colleges and Universities Key Laboratory of Complex System Optimization and Big Data Processing Yulin Normal University Guangxi Yulin537000 China Jagiellonian University in Krakow Faculty of Mathematics and Computer Science ul. Lojasiewicza 6 Krakow30-348 Poland

In this paper we investigate an evolution problem (SDQHVI) which constitutes of the second order differential inclusion driven by a quasi-variational–hemivariational inequality (QHVI) with perturbation operator in Banach spaces. Unlike the existing literature on differential inclusions, on the one hand, the second order differential operator is not assumed to be compact;on the other hand, the solvability of the inequality is proved under non-coercive condition. More precisely, first, it is shown that the solution set of the QHVI with perturbation operator is nonempty, bounded, closed and convex under the KKM theorem and the Minty formulation. Then, an associated multivalued map with the solution set of the QHVI with perturbation operator is introduced, and we prove that it is upper semicontinuous and measurable. Finally, by utilizing Kakutani–Fan–Glicksberg fixed point theorem, a weak topology technique and properties of strong continuous cosine operators, we prove the existence of mild solutions for SDQHVI. © 2023 Elsevier Ltd

关键词： Banach spaces

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