检索结果-内蒙古大学图书馆

Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

作者： Ning Wang Anqi Zhang Jiajia Yang Ling Wang Chenguang Zheng Academy of Medical Engineering and Translational Medicine Medical College Tianjin University Tianjin China Tianjin Key Laboratory of Brain Science and Neuroengineering Tianjin China Haihe Laboratory of Brain-Computer Interaction and Human-Machine Integration Tianjin China

ISBN: (数字)9798350371499

ISBN: (纸本)9798350371505

Spatial memory supported by the hippocampus is a critical cognitive function in daily life. It helps us to navigate to salient goal locations. Hippocampal place cells stably represent the spatial location, while c-Fos-expressing cells (engram cells) contain rich information about the environment, contributing to the encoding and retrieving of memories. However, the role of cFos as a gateway to a more profound comprehension of the mechanisms underlying the process of goal-oriented spatial memory remained poorly understood. In this study, we labeled rats’ c-Fos + neurons by Channelrhodopsin-2 during memory encoding of a specific goal location. A subset of place cells whether they expressed c-Fos was identified optogenetically. As the rats learned the new goal locations, the spatial correlation between task periods remained stable for the c-Fos - place cell, while increased for the c-Fos + place cell. This finding shed light on the processing of goal-oriented spatial memories by the hippocampal network involved in c-Fos. C-Fos - place cells consistently maintained a stable representation of the locations, while c-Fos + place cells exhibited significant flexibility of the goal.

关键词： Correlation Navigation Neurons Cells (biology) Logic gates Encoding Optogenetics Engineering in medicine and biology Hippocampus

来源：评论

学校读者我要写书评

暂无评论

Firing Pattern of Cells in the Hippocampus and Basolateral Amygdala during Novelty Recognition

Firing Pattern of Cells in the Hippocampus and Basolateral A...

引用

Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

作者： Xiaoxin Ren Yimeng Wang Ling Wang Jiajia Yang Chenguang Zheng Academy of Medical Engineering and Translational Medicine Medical College Tianjin University Tianjin China Tianjin Key Laboratory of Brain Science and Neuroengineering Tianjin China Haihe Laboratory of Brain-Computer Interaction and Human-Machine Integration Tianjin China

ISBN: (数字)9798350371499

ISBN: (纸本)9798350371505

Novelty recognition is essential for exploring and collecting unknown but interesting information, in which multiple brain regions related to cognitive memory are involved. Dorsal hippocampus (dHPC) is revealed to be closely associated with spatial memory and basolateral amygdala (BLA) is reported recently to be related to state-dependent encoding of exploratory behavior. However, how the firing pattern of cells in these two brain regions responds to novelty dynamically remains unclear. In this study, we observed that the representations of cells in BLA exhibited shift towards novelty, whereas dHPC cells maintained strong stability after the introduction of novelty, which are both engaged in the execution of novel recognition. Our study may provide new evidence for underlying the internal mechanisms of perception of novelty in the brain.

关键词： Brain In vivo Firing Cells (biology) Encoding Pattern recognition Object recognition Engineering in medicine and biology Hippocampus

来源：评论

学校读者我要写书评

暂无评论

Enhanced Transient Response of Ultrasound Neuromodulation Mediated by Large Conductance Mechanosensitive Ion Channel

Enhanced Transient Response of Ultrasound Neuromodulation Me...

引用

Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

作者： Xin Li Guoying Zhang Chenguang Zheng Yutao Tian Academy of Medical Engineering and Translational Medicine Medical College Tianjin University Tianjin China Tianjin Key Laboratory of Brain Science and Neuroengineering Tianjin China Haihe Laboratory of Brain-Computer Interaction and Human-Machine Integration Tianjin China

ISBN: (数字)9798350371499

ISBN: (纸本)9798350371505

Ultrasound neuromodulation, a burgeoning field aimed at enhancing brain function and behavior, relies on the intricate electrophysiological responses of neurons driven by ion channel dynamics. However, achieving targeted and precise modulation with ultrasound poses a significant challenge. A hypothesis is that mechanosensitive (MS) ion channels may play a pivotal role in achieving the desired specificity in ultrasound effects. Our study involved augmenting MscL-G22S channel expression in specific areas of rats’ hippocampus (HP) and primary visual cortex (V1) via AAV virus delivery. We recorded local field potentials (LFPs) to assess the modulation effect and identified distinct evoked-related potentials (ERPs) in regions overexpressing MscL-G22S channels under anesthesia. Notable variations in the amplitude of negative peaks were observed in the ERPs between HP and V1, highlighting a nuanced response to ultrasound stimulation. These results highlight the complexity and promise of MS channel-mediated neuromodulation, offering critical insights into the development of targeted ultrasound interventions to improve brain function.

关键词： Visualization Ultrasonic imaging Local field potentials Modulation Ions Brain modeling Complexity theory Neuromodulation Hippocampus Viruses (medical)

来源：评论

学校读者我要写书评

暂无评论

Astrocytic TRPA1 as a target in reversing social avoidance by low-intensity focused ultrasound stimulation in mice

Astrocytic TRPA1 as a target in reversing social avoidance b...

引用

Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

作者： Ganjiang Wei Ling Wang Jingnan Zhu Xiao Wang Yuran Zang Jiajia Yang Chenguang Zheng Academy of Medical Engineering and Translational Medicine Medical College Tianjin University Tianjin China Tianjin Key Laboratory of Brain Science and Neuroengineering Tianjin China Haihe Laboratory of Brain-Computer Interaction and Human-Machine Integration Tianjin China

ISBN: (数字)9798350371499

ISBN: (纸本)9798350371505

Social avoidance is a prominent clinical feature of multiple neuropsychiatric disorders. Increasing evidence showed that the medial prefrontal cortex (mPFC) regulates social avoidance with suppression of excitatory neurons. Our previous study found that the low-intensity focused ultrasound (LIFUS), as a novel noninvasive neuromodulation technique, could alleviate the social avoidance of social defeat stress (SDS) model mice by increasing the mPFC excitation. However, the underlying target of LIFUS on mPFC neurons in social defeated mice remains unclear. Here we injected AAV-shRNA to knock down astrocytic TRPA1 in the mPFC, and investigated whether astrocytic TRPA1 played a crucial role in LIFUS modulation. We found that the social avoidance of SDS mice with TRPA1 knocked down was not affected by LIFUS. Furthermore, LIFUS didn’t induce enhanced expression of membrane NMDAR2A and NMDAR2B in SDS mice with TRPA1 knocked down, compared with that in mice infected with the control virus. It is believed that LIFUS can act on astrocytic TRPA1 to improve social avoidance and hence synaptic function.

关键词： Ultrasonic imaging Modulation Brain modeling Mice Biomembranes Neuromodulation Engineering in medicine and biology Viruses (medical) Stress Immune system

来源：评论

学校读者我要写书评

暂无评论

Localisation and decoding of acoustoelectric brain imaging based on anisotropic brain models

Localisation and decoding of acoustoelectric brain imaging b...

引用

IEEE International Symposium on Applications of Ferroelectrics (ISAF)

作者： Xue Wang Chen Zhang Guowei Chen Jia He Mingyu Li Feng He Hao Zhang Minpeng Xu Dong Ming Academy of Medical Engineering and Translational Medicine Tianjin University Tianjin China School of Biomedical Engineering and Technology Tianjin Medical University Tianjin China Haihe Laboratory of Brain -Computer Interaction and Human-Machine Integration Tianjin China

ISBN: (数字)9798350371901

ISBN: (纸本)9798350371918

Acoustoelectric imaging (AEI) combines electroencephalography (EEG) and transcranial focused ultrasound (tFUS) with the advantages of high temporal and spatial resolution, which is expected to provide safe, accurate and non-invasive neurofunctional imaging of the brain. Previous AEI studies were mainly based on isotropic homogeneous media, but the actual skull and brain white matter show anisotropic resistivity distributions, making it difficult for isotropic media to mimic the imaging results of real brain tissue. In this study, a multi-source AEI dipole localisation and decoding platform was established based on a 128-array ultrasound phase-controlled transducer. Using a phantom of imitation brain tissue and an isolated porcine brain tissue as experimental materials, the discharged dipole was raster scanned by focused ultrasound, and the acoustoelectric (AE) signals were decoded and analysed using an envelope decoding algorithm. The results show that the decoding and localisation of AE signals based on the anisotropic phantom was achieved, with a localisation error of less than 0.6 mm, a localisation signal-to-noise ratio (SNR) of at least 18.17 dB, a decoding half-peak width of at least 0.21 mm, and a decoding accuracy of 0.87. This study will further promote the development of AEI in the field of neuroimaging.

关键词： Neuroimaging Brain Ultrasonic imaging Imaging Phantoms Anisotropic Media Electroencephalography Decoding Signal to noise ratio

来源：评论

学校读者我要写书评

暂无评论

Impairments in Spatial Representations of Place Cells and Neural rhythms In APP knock-in rat model 46

Impairments in Spatial Representations of Place Cells and Ne...

引用

46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2024

作者： Wang, Xueling Wang, Yimeng Pang, Keliang Lu, Bai Tian, Yutao Zheng, Chenguang Fudan University Aging and Longevity Institute Institute of Biological Science Zhongshan Hospital Shanghai China Tsinghua University-Peking University Joint Center for Life Sciences Tsinghua University School of Pharmaceutical Sciences IDG/McGovern Institute for Brain Research Beijing China Tianjin University Academy of Medical Engineering and Translational Medicine Medical College Tianjin China Tianjin Key Laboratory of Brain Science and Neuroengineering Tianjin China Haihe Laboratory of Brain-Computer Interaction and Human-Machine Integration Tianjin China

ISBN: (纸本)9798350371499

Alzheimer's disease (AD) is a neurodegenerative disease that severely impacts spatial memory. Place cells in the hippocampus play an important role in spatial memory. However, neuronal activity in the hippocampus is difficult to monitor and study in human AD patients. Thus, it is critical to have an animal model that resembles closely human AD. The newly developed APPNL-G-F rat model, which is a knock-in rat line of the amyloid precursor protein (APP) with Swedish-Beyreuther/Iberian-Arctic mutations, presents a unique opportunity. In this study, we investigated how hippocampal place cells and neural rhythms were impaired in APP rats. Place cells of APP rats showed a less defined spatial tunning and disrupted remapping. In addition, APP rats exhibited decreased power of theta rhythm and slow gamma rhythm. These results suggest that the impairment of spatial memory in APP rats may be caused by the damage of place cells' ability to represent spatial location and abnormal neural rhythm in the hippocampus. © 2024 IEEE.

关键词： Rats

来源：评论

学校读者我要写书评

暂无评论

Eeg-Based Evaluation of Individual Preferences for Diesel Engine Sound Quality

SSRN

引用

SSRN 2024年

作者： Guo, Mingkun Han, Siyang Liu, Hongxing Bai, Yanru Lin, Jiewei Ni, Guangjian Academy of Medical Engineering and Translational Medicine Tianjin University Tianjin China Beijing Shijitan Hospital Capital Medical University Beijing China Haihe Laboratory of Brain-computer Interaction and Human-machine Integration Tianjin China State Key Laboratory of Engines Tianjin University Tianjin China

Diesel engines are prevalent in industrial settings and everyday life, but their high compression rates often result in significant noise emissions. Studies have shown that prolonged exposure to such noise can lead to negative emotional states and health issues. Traditional evaluations of sound quality, which typically rely on subjective and objective assessments, often reflect the preferences of the general population and psychoacoustic perceptions, respectively. However, these evaluations fail to account for the physiological processes involved in sound perception adequately. Electroencephalogram (EEG) signals can provide insights into the brain's physiological responses to external stimuli. This paper proposes an EEG-based method for evaluating sound quality and understanding individual sound quality preferences. EEG signals were collected while participants evaluated diesel engine noise samples. The subjective and psychoacoustic annoyance of the noise samples was analyzed, and EEG features were extracted. The correlation between EEG features and subjective and objective annoyance confirms the feasibility of the proposed method. © 2024, The Authors. All rights reserved.

关键词： Electroencephalography

来源：评论

学校读者我要写书评

暂无评论

Eeg-Based Evaluation of Individual Preferences for Diesel Engine Noise Sound Quality

SSRN

引用

SSRN 2024年

Diesel engines are prevalent in industrial settings and everyday life, but their high compression rates often result in significant noise emissions. Studies have shown that prolonged exposure to such noise can lead to negative emotional states and health issues. Traditional evaluations of sound quality, which typically rely on subjective and objective assessments, often reflect the preferences of the general population and psychoacoustic perceptions, respectively. However, these evaluations fail to account for the physiological processes involved in sound perception adequately. Electroencephalogram (EEG) signals can provide insights into the brain physiological responses to external stimuli. This paper proposes an EEG-based method for evaluating the sound quality of diesel engine noise and understanding individual sound quality preferences. EEG signals were collected while participants evaluated diesel engine noise samples. The subjective and psychoacoustic annoyance of the noise samples was analyzed, and EEG features were extracted. The correlation between EEG features and subjective and objective annoyance confirms the feasibility of the proposed method. © 2024, The Authors. All rights reserved.

关键词： Electroencephalography

来源：评论

学校读者我要写书评

暂无评论

Temporal aware Mixed Attention-based Convolution and Transformer Network for cross-subject EEG emotion recognition

引用

computers in Biology and Medicine 2024年 181卷 108973-108973页

作者： Si, Xiaopeng Huang, Dong Liang, Zhen Sun, Yulin Huang, He Liu, Qile Yang, Zhuobin Ming, Dong Academy of Medical Engineering and Translational Medicine State Key Laboratory of Advanced Medical Materials and Devices Haihe Laboratory of Brain-computer Interaction and Human-machine Integration Tianjin Key Laboratory of Brain Science and Neural Engineering Institute of Applied Psychology Tianjin University Tianjin300072 China School of Biomedical Engineering Medical School Shenzhen University Guangdong Provincial Key Laboratory of Biomedical Measurements and Ultrasound Imaging Shenzhen518060 China

Emotion recognition is crucial for human–computer interaction, and electroencephalography (EEG) stands out as a valuable tool for capturing and reflecting human emotions. In this study, we propose a hierarchical hybrid model called Mixed Attention-based Convolution and Transformer Network (MACTN). This model is designed to collectively capture both local and global temporal information and is inspired by insights from neuroscientific research on the temporal dynamics of emotions. First, we introduce depth-wise temporal convolution and separable convolution to extract local temporal features. Then, a self-attention-based transformer is used to integrate the sparse global emotional features. Besides, channel attention mechanism is designed to identify the most task-relevant channels, facilitating the capture of relationships between different channels and emotional states. Extensive experiments are conducted on three public datasets under both offline and online evaluation modes. In the multi-class cross-subject online evaluation using the THU-EP dataset, MACTN demonstrates an approximate 8% enhancement in 9-class emotion recognition accuracy in comparison to state-of-the-art methods. In the multi-class cross-subject offline evaluation using the DEAP and SEED datasets, a comparable performance is achieved solely based on the raw EEG signals, without the need for prior knowledge or transfer learning during the feature extraction and learning process. Furthermore, ablation studies have shown that integrating self-attention and channel-attention mechanisms improves classification performance. This method won the Emotional BCI Competition's final championship in the World Robot Contest. The source code is available at https://***/ThreePoundUniverse/MACTN. © 2024 Elsevier Ltd

关键词： Emotion Recognition

来源：评论

学校读者我要写书评

暂无评论

Congenital hydrocephalus:a review of recent advances in genetic etiology and molecular mechanisms

引用

Military Medical Research 2024年第6期11卷 942-958页

作者： Xiu-Yun Liu Xin Song Marek Czosnyka Chiara Robba Zofia Czosnyka Jennifer Lee Summers Hui-Jie Yu Guo-Yi Gao Peter Smielewski Fang Guo Mei-Jun Pang Dong Ming Medical School Tianjin UniversityTianjin 300072China State Key Laboratory of Advanced Medical Materials and Devices Tianjin UniversityTianjin 300072China Haihe Laboratory of Brain-Computer Interaction and Human-Machine Integration Tianjin 300380China School of Pharmaceutical Science and Technology Tianjin University300072 TianjinChina Department of Clinical Neurosciences Addenbrooke’s HospitalUniversity of CambridgeCambridge CB20QQUK San Martino Policlinico Hospital IRCCS for Oncology and Neuroscience16132 GenoaItaly Department of Anesthesiology and Critical Care Medicine Johns Hopkins UniversityBaltimoreMD 21287USA Department of Neurosurgery Tianjin Medical University General HospitalTianjin 300052China Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China Department of Neurosurgery Tianjin Huanhu HospitalTianjin 300350China

The global prevalence rate for congenital hydrocephalus(CH)is approximately one out of every five hundred births with multifaceted predisposing factors at *** influences stand as a major contributor to CH pathogenesis,and epidemiological evidence suggests their involvement in up to 40%of all cases observed *** about an individual’s genetic susceptibility can significantly improve prognostic precision while aiding clinical decision-making ***,the precise genetic etiology has only been pinpointed in fewer than 5%of human *** occurrences of CH cases are required for comprehensive gene sequencing aimed at uncovering additional potential genetic loci.A deeper comprehension of its underlying genetics may offer invaluable insights into the molecular and cellular basis of this brain *** review provides a summary of pertinent genes identified through gene sequencing technologies in humans,in addition to the 4 genes currently associated with CH(2 X-linked genes L1CAM and AP1S2,2 autosomal recessive MPDZ and CCDC88C).Others predominantly participate in aqueduct abnormalities,ciliary movement,and nervous system *** prospective CH-related genes revealed through animal model gene-editing techniques are further outlined,focusing mainly on 4 pathways,namely cilia synthesis and movement,ion channels and transportation,Reissner’s fiber(RF)synthesis,cell apoptosis,and ***,the proper functioning of motile cilia provides significant impulsion for cerebrospinal fluid(CSF)circulation within the brain ventricles while mutations in cilia-related genes constitute a primary cause underlying this *** far,only a limited number of CH-associated genes have been identified in *** integration of genotype and phenotype for disease diagnosis represents a new trend in the medical *** models provide insights into the pathogenesis of CH and contribute to our understanding of its association w

关键词： Congenital hydrocephalus Genetic disease Central system Cilia Ventricle

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：