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检索条件"机构=Harvard/MIT MD–PhD Program"
157 条 记 录,以下是11-20 订阅
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Thymidine nucleotide metabolism controls human telomere length (vol 55, pg 568, 2023)
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NATURE GENETICS 2023年 第7期55卷 1251-1251页
作者: Mannherz, William Agarwal, Suneet Boston Childrens Hosp Oncol & Stem Cell Program Div Hematol Boston MA 02115 USA Dana Farber Canc Inst Pediat Oncol Boston MA 02215 USA Harvard Med Sch Harvard Stem Cell Inst Harvard Initiat RNA Med Biol & Biomed Sci Program Boston MA 02115 USA Harvard Med Sch Harvard MIT MD PhD Program Dept Pediat Boston MA 02115 USA
Telomere length in humans is associated with lifespan and severe diseases, yet the genetic determinants of telomere length remain incompletely defined. Here we performed genome-wide CRISPR–Cas9 functional telomere le... 详细信息
来源: 评论
Alterations in facial expressions in individuals at risk for psychosis: a facial electromyography approach using emotionally evocative film clips
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PSYCHOLOGICAL MEDICINE 2023年 第12期53卷 5829-5838页
作者: Gupta, Tina Osborne, K. Juston Nadig, Ajay Haase, Claudia M. mittal, Vijay A. Univ Pittsburgh Dept Psychiat Pittsburgh PA 15213 USA Northwestern Univ Dept Psychol Evanston IL USA Harvard Med Sch Harvard MIT MD PhD Program Boston MA 02115 USA Northwestern Univ Sch Educ & Social Policy Evanston IL USA
Background Negative symptoms such as blunted facial expressivity are characteristic of schizophrenia. However, it is not well-understood if and what abnormalities are present in individuals at clinical high-risk (CHR)... 详细信息
来源: 评论
Neurosurgery elucidates somatic mutations
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SCIENCE 2023年 第6677期382卷 1360-1362页
作者: Maury, Eduardo A. Walsh, Christopher A. Kahle, Kristopher T. Boston Childrens Hosp Manton Ctr Orphan Dis Div Genet & Genom Boston MA 02115 USA Harvard Med Sch Harvard MIT MD PhD Program Boston MA 02115 USA Broad Inst MIT & Harvard Program Med & Populat Genet Cambridge MA 02142 USA Boston Childrens Hosp Howard Hughes Med Inst Boston MA 02115 USA Broad Inst MIT & Harvard Program Neurosci Cambridge MA USA Boston Childrens Hosp Dept Neurosurg Boston MA USA Massachusetts Gen Hosp Dept Neurosurg Boston MA USA
Surgical innovation is helping to identify roles for somatic mutations in brain disorders Somatic variants are genomic alterations present in some cells of the body but not in others. In contrast to inherited germline...
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Insights into Neurodegeneration in Parkinson's Disease from Single-Cell and Spatial Genomics
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MOVEMENT DISORDERS 2023年 第4期38卷 518-525页
作者: Kamath, Tushar Macosko, Evan Z. Broad Inst Stanley Ctr Psychiat Res Cambridge MA USA Harvard Med Sch Cambridge MA USA Harvard Univ Harvard MIT MD PhD Program Cambridge MA USA Massachusetts Gen Hosp Dept Psychiat Boston MA USA Broad Inst Stanley Ctr Psychiat Res 75 Ames St Cambridge MA 02139 USA
Parkinson's disease (PD) is pathologically defined by the death of dopaminergic (DA) neurons within the pars compacta of the substantia nigra. To date, the cause of this multifaceted disease remains largely unclea... 详细信息
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Addressing the longitudinal components of surgical treatments
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EUROPEAN JOURNAL OF EPIDEMIOLOGY 2023年 第10期38卷 1019-1023页
作者: Messinger, Chelsea J. Madenci, Arin L. Wanis, Kerollos Nashat Harvard TH Chan Sch Publ Hlth Dept Epidemiol 677 Huntington Ave Boston MA 02115 USA Harvard Med Sch Harvard MIT MD PhD Program Boston MA 02115 USA Boston Childrens Hosp Dept Surg Boston MA USA Western Univ Dept Surg London ON Canada
Despite their pre- and postoperative components, surgical treatment strategies have typically been cast as point interventions in causal inference research. When longitudinal perioperative components affect outcomes o... 详细信息
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A good step toward low-cost prognostication of liver-related outcome awaits more validation
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JOURNAL OF HEPATOLOGY 2022年 第3期77卷 887-889页
作者: Song, Jiunn Jiang, Z. Gordon Harvard Med Sch Harvard MIT MD PhD Program Boston MA 02115 USA Harvard Med Sch Beth Israel Deaconess Med Ctr Dept Med Div Gastroenterol & Hepatol Boston MA 02115 USA
来源: 评论
Model-directed generation of artificial CRISPR-Cas13a guide RNA sequences improves nucleic acid detection
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NATURE BIOTECHNOLOGY 2024年 1-8页
作者: Mantena, Sreekar Pillai, Priya P. Petros, Brittany A. Welch, Nicole L. Myhrvold, Cameron Sabeti, Pardis C. Metsky, Hayden C. Broad Inst MIT & Harvard Cambridge MA 02142 USA Harvard Univ Dept Stat Cambridge MA USA Harvard Univ Dept Mol & Cellular Biol Cambridge MA USA Harvard Med Sch Div Hlth Sci & Technol Cambridge MA USA MIT Cambridge MA USA Harvard Massachusetts Inst Technol MD PhD Program Boston MA USA Harvard Med Sch Dept Syst Biol Boston MA USA Princeton Univ Dept Mol Biol Princeton NJ USA Princeton Univ Dept Chem & Biol Engn Princeton NJ USA Princeton Univ Omenn Darling Bioengn Inst Princeton NJ USA Princeton Univ Dept Chem Princeton NJ USA Howard Hughes Med Inst Chevy Chase MD 20815 USA Harvard Univ Dept Organism & Evolutionary Biol Cambridge MA 02138 USA Harvard TH Chan Sch Publ Hlth Dept Immunol & Infect Dis Boston MA 02115 USA
CRISPR guide RNA sequences deriving exactly from natural sequences may not perform optimally in every application. Here we implement and evaluate algorithms for designing maximally fit, artificial CRISPR-Cas13a guides...
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Impulsivity and risk-seeking as Bayesian inference under dopaminergic control
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NEUROPSYCHOPHARMACOLOGY 2022年 第2期47卷 465-476页
作者: Mikhael, John G. Gershman, Samuel J. Harvard Med Sch Program Neurosci Boston MA 02115 USA Harvard Med Sch MD PhD Program Boston MA 02115 USA Harvard Univ Dept Psychol 33 Kirkland St Cambridge MA 02138 USA Harvard Univ Ctr Brain Sci Cambridge MA 02138 USA MIT Ctr Brains Minds & Machines 77 Massachusetts Ave Cambridge MA 02139 USA
Bayesian models successfully account for several of dopamine (DA)'s effects on contextual calibration in interval timing and reward estimation. In these models, tonic levels of DA control the precision of stimulus... 详细信息
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Rare germline structural variants increase risk for pediatric solid tumors
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SCIENCE 2025年 第6729期387卷 eadq0071页
作者: Gillani, Riaz Collins, Ryan L. Crowdis, Jett Garza, Amanda Jones, Jill K. Walker, Mark Sanchis-Juan, Alba Whelan, Christopher W. Pierce-Hoffman, Emma Talkowski, Michael E. Brand, Harrison Haigis, Kevin LoPiccolo, Jaclyn AlDubayan, Saud H. Gusev, Alexander Crompton, Brian D. Janeway, Katherine A. Van Allen, Eliezer M. Dana Farber Canc Inst Dept Pediat Oncol Boston MA 02115 USA Broad Inst MIT & Harvard Canc Program Cambridge MA 02142 USA Harvard Med Sch Boston MA 02115 USA Boston Childrens Hosp Boston MA 02115 USA Dana Farber Canc Inst Dept Med Oncol Boston MA 02115 USA Harvard Med Sch Harvard MIT MD PhD Program Boston MA 02115 USA Broad Inst MIT & Harvard Data Sci Platform Cambridge MA 02142 USA Massachusetts Gen Hosp Ctr Genom Med Boston MA 02114 USA Broad Inst MIT & Harvard Program Med & Populat Genet Cambridge MA 02142 USA Broad Inst MIT & Harvard Stanley Ctr Psychiat Res Cambridge MA 02142 USA Massachusetts Gen Hosp Dept Neurol Boston MA 02114 USA Dana Farber Canc Inst Dept Canc Biol Boston MA 02115 USA Brigham & Womens Hosp Dept Med 75 Francis St Boston MA 02115 USA Brigham & Womens Hosp Div Genet 75 Francis St Boston MA 02115 USA King Saudi bin Abdulaziz Univ Hlth Sci Coll Med Riyadh Saudi Arabia Harvard TH Chan Sch Publ Hlth Dept Epidemiol Boston MA USA Dana Farber Canc Inst Ctr Canc Genom Boston MA 02115 USA
Pediatric solid tumors are a leading cause of childhood disease mortality. In this work, we examined germline structural variants (SVs) as risk factors for pediatric extracranial solid tumors using germline genome seq...
来源: 评论
SLC25A38 is required for mitochondrial pyridoxal 5'-phosphate (PLP) accumulation
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NATURE COMMUNICATIONS 2025年 第1期16卷 1-19页
作者: Pena, Izabella A. Shi, Jeffrey S. Chang, Sarah M. Yang, Jason Block, Samuel Adelmann, Charles H. Keys, Heather R. Ge, Preston Bathla, Shveta Witham, Isabella H. Sienski, Grzegorz Nairn, Angus C. Sabatini, David M. Lewis, Caroline A. Kory, Nora Vander Heiden, Matthew G. Heiman, Myriam MIT Picower Inst Learning & Memory Cambridge MA 02139 USA MIT Dept Brain & Cognit Sci Cambridge MA 02139 USA MIT Dept Biol Cambridge MA USA MIT David H Koch Inst Integrat Canc Res Cambridge MA USA Harvard MIT MD PhD Program Boston MA USA Whitehead Inst Biomed Res Cambridge MA USA Massachusetts Gen Hosp Ctr Canc Res Boston MA USA Harvard Med Sch Massachusetts Gen Hosp Cutaneous Biol Res Ctr Dept Dermatol Boston MA USA Yale Sch Med Dept Psychiat New Haven CT USA MIT Dept Biol Engn Cambridge MA USA Inst Organ Chem & Biochem IOCB Prague Czech Republic UMass Chan Med Sch Program Mol Med Worcester MA USA Harvard TH Chan Sch Publ Hlth Boston MA USA Dana Farber Canc Inst Boston MA USA Childrens Hosp Eastern Ontario CHEO Res Inst Ottawa ON Canada
Many essential proteins require pyridoxal 5'-phosphate, the active form of vitamin B6, as a cofactor for their activity. These include enzymes important for amino acid metabolism, one-carbon metabolism, polyamine ...
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