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Current Status of Objectification of Four Diagnostic Methods on Constitution Recognition of Chinese Medicine

Chinese Journal of Integrative Medicine 2022年第12期28卷 1137-1146页

作者： LI Cong-cong YAN Xin-sheng LIU Ming-hao TENG Gui-fa School of Information Science and Technology Hebei Agricultural UniversityBaodingHebei Province 071001China Hebei Key Laboratory of Agricultural Big Data BaodingHebei Province 071001China

Chinese medicine(CM)has thousands of years of experience in prevention of *** for CM,people's constitution is closely related to their health status,thus recognition of CM constitution is the fundamental and core contentof research on constitution *** development of technologies such as sensors,arificial intelligence and big data,objectification of the four diagnostic methods of CM has gradually matured,bringing changes in the mindset and innovations in technical means for recognition of CM *** paper presents a systematic review of the latest research trends in constitution recognition based on objectification of diagnostic methods in CM.

关键词： Chinese medicine constitution recognition four diagnostic methods objectification machine learning deep learning

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Predicting Transcription Factor Binding Signals Based on a Novel Encoder-Decoder Framework 2nd

Predicting Transcription Factor Binding Signals Based on a N...

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2nd International Conference on Applied Intelligence, ICAI 2024

作者： Wang, Siguo Li, Zhipeng Zhang, Qinhu Ningbo Institute of Digital Twin Eastern Institute of Technology No. 568 Tongxin Road Zhuangshi Street Zhejiang Ningbo315201 China Big Data and Intelligent Computing Research Center Guangxi Academy of Science Nanning530007 China Institute for Regenerative Medicine Medical Innovation Center and State Key Laboratory of Cardiology School of Medicine Shanghai East Hospital Tongji University Shanghai200123 China

ISBN: (纸本)9789819619061

The transcription process is the initial step in gene expression and the core of the regulatory mechanism, in which transcription factors control gene expression through interactions with particular DNA sequences. Therefore, identification of transcription factor binding sites (TFBSs) provides theoretical basis for further dissection of transcriptional regulatory mechanisms and disease diagnosis. To address the limitations of current research on TFBSs, a novel symmetric Encoder-Decoder framework is proposed for predicting transcription factor binding signals values at base sites. Our approach utilizes word vectors to encode DNA sequences, followed by encoders that progressively extract feature representations from these sequences. We then employ Gated Recurrent Unit (GRU) to capture the contextual dependencies within the sequences, ultimately using decoders to reconstruct the binding signal values for the DNA sequence sites. In order to access the effectiveness of the proposed symmetric Encoder-Decoder framework, some experiments were conducted on 20 ChIP-seq datasets, and the results show that the proposed novel method outperformers several existing advanced methods. © The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2025.

关键词： DNA sequences

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A Self-Supervised Transfer Learning Framework for Gland Segmentation in Colorectal Cancer Histopathology with Limited Labeled data 2nd

A Self-Supervised Transfer Learning Framework for Gland Segm...

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2nd International Conference on Applied Intelligence, ICAI 2024

作者： Wen, Huer Wu, Yan Huang, De-Shuang Institute for Regenerative Medicine Medical Innovation Center and State Key Laboratory of Cardiology Shanghai East Hospital School of Medicine Tongji University Shanghai200123 China Big Data and Intelligent Computing Research Center Guangxi Academy of Science Nanning530007 China Ningbo Institute of Digital TwinEastern Institute of Technology No. 568 Tongxin Road Zhuangshi Street Zhejiang Ningbo315201 China

ISBN: (纸本)9789819619061

Accurate gland segmentation in colorectal cancer histopathology images is crucial for diagnosis and grading but is hampered by the limited availability of annotated data. To develop a robust and accurate gland segmentation method that effectively leverages unlabeled data to overcome the limitations of small annotated datasets. We propose a novel framework that combines self-supervised learning and transfer learning. A vision transformer is pre-trained using DINOv2 on a large unlabeled dataset (IMP-CRS-2024) and then fine-tuned on the GlaS dataset using a lightweight decoder and a boundary-aware loss function that combines Dice loss and a distance transform-weighted boundary loss. Our method achieves state-of-the-art performance on the GlaS dataset, surpassing existing methods in terms of F1-score, Object Dice, and Object Hausdorff distance. An ablation study confirms the benefits of both the self-supervised pre-training and the boundary-aware loss. Our approach effectively addresses the challenge of limited annotated data in gland segmentation, offering a promising solution for improving the accuracy and efficiency of colorectal cancer diagnosis. The framework can be generalized to other histopathology image analysis tasks and cancer types. © The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2025.

关键词： Self-supervised learning

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Time-varying formation for general linear multi-agent systems via distributed event-triggered control under switching topologies

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Chinese Physics B 2018年第4期27卷 228-235页

作者： Jin-Huan Wang Yu-Ling Xu Jian Zhang De-Dong Yang School of Science Hebei Provincial Key Laboratory of Big Data Calculation Hebei University of Technology Tianjin 300401 China School of Control Science and Engineering Hebei University of Technology Tianjin 300130 China

This paper investigates the time-varying formation problem for general linear multi-agent systems using distributed event-triggered control *** from the previous works,to achieve the desired time-varying formation,a distributed control scheme is designed in an event-triggered way,in which for each agent the controller is triggered only at its own event *** interaction topology among agents is assumed to be *** common Lyapunov function as well as Riccati inequality is applied to solve the time-varying formation ***,the Zeno behavior of triggering time sequences can be excluded for each ***,a simulation example is presented to illustrate the effectiveness of the theoretical results.

关键词： multi-agent systems time-varying formation switching topologies event-triggered control

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Edge-Driven Industrial computing Power Networks: Digital Twin-Empowered Service Provisioning by Hybrid Soft Actor-Critic

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IEEE Transactions on Vehicular Technology 2025年

作者： Zhang, Long Song, Deng-Ao Zhang, Hongliang Tian, Ni Zhuang, Zirui Niyato, Dusit Han, Zhu Hebei University of Engineering School of Information and Electrical Engineering Handan056038 China Peking University State Key Laboratory of Advanced Optical Communication Systems and Networks School of Electronics Beijing100871 China Beijing University of Posts and Telecommunications State Key Laboratory of Networking and Switching Technology Beijing100876 China Nanyang Technological University College of Computing and Data Science 639798 Singapore University of Houston Department of Electrical and Computer Engineering HoustonTX77004 United States Kyung Hee University Department of Computer Science and Engineering Seoul446-701 Korea Republic of

With the proliferation of data-intensive industrial applications, the collaboration of computing powers among standalone edge servers is vital to provision such services for smart devices. In this paper, we propose an edge-driven industrial computing power network (CPN) by orchestrating the computing and network resources of edge servers through the centralized resource scheduling and decentralized task computing. However, efficient task offloading and collaborative processing is challenging, which requires higher degrees of network automation and intelligence. Therefore, we incorporate digital twins (DTs) into the edge-driven CPN architecture, where the DTs are created as the digital replicas to assist both the computation offloading and collaborative processing. A joint optimization problem of the computing power assignment, service association, task partition, and transmit power control is formulated for maximizing the system average weighted utility. Due to the temporal-spatial variability of tasks and the resulted dynamic environment, we transform the original problem as a Markov decision process aiming at maximizing the long-term average weighted utility. To efficiently handle the high-dimensional discrete-continuous action space, a hybrid soft actor-critic based deep reinforcement learning algorithm is developed for optimizing the joint design. Simulation results validate the superiority of our proposed algorithm over the benchmarks, showing the significant gains obtained by integrating DTs into the edge-driven CPN. © 1967-2012 IEEE.

关键词： Markov processes

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Agentic Knowledgeable Self-awareness

arXiv

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arXiv 2025年

作者： Qiao, Shuofei Qiu, Zhisong Ren, Baochang Wang, Xiaobin Ru, Xiangyuan Zhang, Ningyu Chen, Xiang Jiang, Yong Xie, Pengjun Huang, Fei Chen, Huajun Zhejiang University China Alibaba Group China Nanjing University of Aeronautics and Astronautics China Zhejiang Key Laboratory of Big Data Intelligent Computing China

Large Language Models (LLMs) have achieved considerable performance across various agentic planning tasks. However, traditional agent planning approaches adopt a "flood irrigation" methodology that indiscriminately injects gold trajectories, external feedback, and domain knowledge into agent models. This practice overlooks the fundamental human cognitive principle of situational self-awareness during decision-making—the ability to dynamically assess situational demands and strategically employ resources during decision-making. We propose agentic knowledgeable self-awareness to address this gap, a novel paradigm enabling LLM-based agents to autonomously regulate knowledge utilization. Specifically, we propose KnowSelf, a data-centric approach that applies agents with knowledgeable self-awareness like humans. Concretely, we devise a heuristic situation judgement criterion to mark special tokens on the agent’s self-explored trajectories for collecting training data. Through a two-stage training process, the agent model can switch between different situations by generating specific special tokens, achieving optimal planning effects with minimal costs. Our experiments demonstrate that KnowSelf can outperform various strong baselines on different tasks and models with minimal use of external knowledge1 Copyright © 2025, The Authors. All rights reserved.

关键词： Risk perception

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A data Augmentation Method for Disease Diagnosis Based on Single Cell Omics data 2nd

A Data Augmentation Method for Disease Diagnosis Based on Si...

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2nd International Conference on Applied Intelligence, ICAI 2024

作者： Zhuang, Han Zhang, Qinhu Ningbo Institute of Digital Twin Eastern Institute of Technology No. 568 Tongxin Road Zhuangshi Street Zhejiang Ningbo315201 China Big Data and Intelligent Computing Research Center Guangxi Academy of Science Nanning530007 China Institute for Regenerative Medicine Medical Innovation Center and State Key Laboratory of Cardiology Shanghai East Hospital School of Medicine Tongji University Shanghai200123 China

ISBN: (纸本)9789819619061

Single cell omics data has enabled bioinformatics methods to identify cell type, infer gene regulatory network and beyond. Besides these great advances, there is active research about how to predict patients’ diagnosis based on cell predicted disease status. In this study, we propose a computational method consisting of a resampling method and an AI model to perform disease diagnosis with single cell omics data. According to our analysis, our proposed method outperforms baseline methods on three public datasets and is effective for disease diagnosis. © The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2025.

关键词： disease diagnosis resampling single cell omics

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FaceBench: A Multi-View Multi-Level Facial Attribute VQA dataset for Benchmarking Face Perception MLLMs

arXiv

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arXiv 2025年

作者： Wang, Xiaoqin Ma, Xusen Hou, Xianxu Ding, Meidan Li, Yudong Chen, Junliang Chen, Wenting Peng, Xiaoyang Shen, Linlin Computer Vision Institute College of Computer Science and Software Engineering Shenzhen University China National Engineering Laboratory for Big Data System Computing Technology Shenzhen University China Guangdong Provincial Key Laboratory of Intelligent Information Processing China AIAC Xi’an Jiaotong-Liverpool University China Tsinghua University China The Hong Kong Polytechnic University Hong Kong City University of Hong Kong Hong Kong Sun Yat-sen University China

Multimodal large language models (MLLMs) have demonstrated remarkable capabilities in various tasks. However, effectively evaluating these MLLMs on face perception remains largely unexplored. To address this gap, we introduce FaceBench, a dataset featuring hierarchical multi-view and multi-level attributes specifically designed to assess the comprehensive face perception abilities of MLLMs. Initially, we construct a hierarchical facial attribute structure, which encompasses five views with up to three levels of attributes, totaling over 210 attributes and 700 attribute values. Based on the structure, the proposed FaceBench consists of 49,919 visual question-answering (VQA) pairs for evaluation and 23,841 pairs for fine-tuning. Moreover, we further develop a robust face perception MLLM baseline, Face-LLaVA, by training with our proposed face VQA data. Extensive experiments on various mainstream MLLMs and Face-LLaVA are conducted to test their face perception ability, with results also compared against human performance. The results reveal that, the existing MLLMs are far from satisfactory in understanding the fine-grained facial attributes, while our Face-LLaVA significantly outperforms existing open-source models with a small amount of training data and is comparable to commercial ones like GPT-4o and Gemini. The dataset will be released at https://***/CVI-SZU/FaceBench. Copyright © 2025, The Authors. All rights reserved.

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Predicting the Risk of Incident Cardiovascular Disease Using Retinal Vessel Caliber Measured by Artificial Intelligence in a Chinese Community-Based Population

SSRN

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SSRN 2025年

作者： Luo, Xingyu Yang, Guangzhengao Fan, Fangfang Jiang, Yimeng Jia, Jia Zhao, Jie Chen, Zifan Yan, Shenshen She, Haicheng Zheng, Bo Zhang, Li Zhang, Yan Department of Cardiology Peking University First Hospital Beijing China Institute of Cardiovascular Disease Peking University First Hospital Beijing China Center for Data Science Peking University Beijing China National Engineering Laboratory for Big Data Analysis and Applications Peking University Beijing China Peking University Changsha Institute for Computing and Digital Economy Beijing China Beijing Tongren Eye Center Beijing Tongren Hospital Capital Medical University Beijing Ophthalmology and Visual Science Key Lab Beijing China

Background: The predictive value of retinal vessel caliber, measured through artificial intelligence (AI), for incident cardiovascular disease (CVD) risk remains to be explored. Our study aimed to investigate the association between AI-measured retinal vessel caliber and the risk of incident CVD in a Chinese community-based population. Methods: We conducted a prospective cohort study on subjects from a Beijing community in China who were free of prevalent stroke or myocardial infarction and underwent retinal photography at baseline. By deep-learning algorithm, retinal vessel caliber measurements, including central retinal arteriolar equivalent (CRAE), central retinal venular equivalent (CRVE), and arteriolar-to-venular ratio (AVR), were obtained from 0.5 to 1 disc diameter from the optic disc margin. The primary endpoint was an incident major adverse cardiovascular event (MACE), defined as a composite of first non-fatal stroke, first non-fatal acute myocardial infarction (AMI), and cardiovascular death. The secondary endpoints included first stroke, first AMI, and cardiovascular death. Findings: A total of 3,585 participants were included. The mean age was 56.49 ± 8.94 years, and 2335 (65.1%) were female. Prevalence of prior hypertension and diabetes was 1594 (44.5%) and 676 (18.9%), respectively. The mean values for CRAE, CRVE, and AVR were 190.83 ± 29.92 μm, 278.26 ± 36.34 μm, and 0.69 ± 0.08, respectively. During the follow-up (median, 7.53 years), there were 293 cases of incident MACE (8.2%), 226 strokes (6.3%), 57 AMIs (1.6%), and 44 cardiovascular deaths (1.2%). The Kaplan–Meier curves showed significant differences in cumulative hazards of the primary endpoint among tertiles of CRAE, CRVE, and AVR. In Cox proportional-hazards models adjusting for covariates, CRAE was negatively associated with the risk of incident MACE (per 10 μm increase, hazard ratio [HR] = 0.95, 95% confidence interval [CI]: 0.92-0.99, P = 0.009) and the risk of incident stroke (per 10 μm

关键词： Risk assessment

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Auction Theory and Game Theory Based Pricing of Edge computing Resources: A Survey

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IEEE Internet of Things Journal 2025年

作者： Yu, Jiguo Liu, Shun Zou, Yifei Wang, Guijuan Hu, Chunqiang University of Electronic Science and Technology of China School of Information and Software Engineering Chengdu610054 China Qilu University of Technology Big Data Institute Jinan250353 China Qufu Normal University School of Computer Science Shandong Rizhao China Shandong University School of Computer Science and Technology Shandong Qingdao266237 China Key Laboratory of Computing Power Network and Information Security Ministry of Education Shandong Computer Science Center Jinan250353 China Shandong Fundamental Research Center for Computer Science Shandong Provincial Key Laboratory of Computer Networks Jinan250353 China Chongqing University School of Big Data and Software Engineering Chongqing400044 China

The proliferation of Internet of Things (IoT) devices and edge computing applications has heightened the demand for efficient resource allocation and pricing mechanisms. Effective pricing strategies play a crucial role in optimizing resource utilization, reducing latency, and ensuring fair resource distribution among users. Both auction theory and game theory have emerged as fundamental economic frameworks for designing pricing mechanisms in edge computing. This paper presents a comprehensive survey of pricing strategies that leverage both auction and game theory, systematically categorizing existing research based on auction mechanisms and game-theoretic models. Unlike previous surveys that focus solely on auction-based pricing, this work integrates game-theoretic perspectives, providing a holistic analysis of strategic interactions in edge computing resource allocation. Furthermore, we discuss key challenges, emerging trends, and future research directions aimed at enhancing efficiency, fairness, and privacy protection in cloud-edge collaborative computing environments. © 2014 IEEE.

关键词： Mobile edge computing

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