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SSRN 2024年

作者： Zhang, Xiaodan Liu, Lili Wang, Yuantu Su, Kenan Cheng, Weiwei Xu, Baocheng Jiao, Xueyuan College of Food and Bioengineering National Experimental Teaching Demonstration Center for Food Processing and Security Henan Engineering Technology Research Center of Food Raw Materials International Joint Laboratory of Food Processing and Quality Safety Control of Henan Province Henan Engineering Technology Research Center of Food Microbiology Henan University of Science and Technology Luoyang471023 China

In this study, the encapsulation and structural characteristics of the self-assembled liposome nanoparticles formed by epigallocatechin gallate (EGCG) and alcohol dehydrogenase (ADH) were studied. According to the results, EGCG significantly increased the catalytic activity of ADH with a 33.33% activation rate and the liposomes were able to entrap EGCG-ADH with an effectiveness of 88.94%. The self-assembled monolayers had nanometer-sized particles, and the excellent self-assembled system was demonstrated by the low PDI value and high surface absolute potential. The scanning electron microscope showed that the self-assembled liposome nanoparticles was honeycomb, groove-shaped, and rough. The spectroscopic results showed that EGCG-ADH complex was formed through hydrogen bond, which changed the secondary structure of the liposome, and verified EGCG-ADH liposome nanoparticle system was successfully prepared. In vitro digestion experiments showed that the gastrointestinal tolerance and antioxidant activity of EGCG-ADH liposome nanoparticles were significantly higher than those of free EGCG-ADH. © 2024, The Authors. All rights reserved.

关键词： Self assembly

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Ferulic acid alleviates the reduction of beef myofibrillar protein digestibility mediated by protein oxidation: Insight from peptide release

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food Science and Human Wellness 2024年

作者： Yantao Yin Yongcun Lu Naiyong Xiao Shucheng Liu Wangang Zhang College of Food Science and Technology， Guangdong Ocean University， Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety， Guangdong Provincial Engineering Laboratory for Marine Biological Products， Guangdong Provincial Engineering Technology Research Center of Seafood Key Laboratory of Meat Processing and Quality Control， College of Food Science and Technology， Nanjing Agricultural University

This study investigated the protective effect of ferulic acid (FA) on the digestibility of oxidized beef myofibrillar protein (MP). MP were treated with varying concentrations of FA (20， 40， and 80 μmol/g protein) and then exposed to oxidation. The results showed that FA inhibited carbonyl in a dose-dependent manner (P < 0.05). Fluorescence spectroscopy and molecular docking studies revealed FA was bonded to MP via hydrophobic interactions and hydrogen bonds. SDS-PAGE and TEM analysis indicated that FA mitigated the aggregation of oxidized MP. Peptidomic analysis showed FA protected 34.24% peptides recover from oxidation loss， and theses recovered peptide were mainly distributed in hydrophobic regions and lysine sites. In vitro digestion showed FA remarkably improved digestibility of oxidized MP (P < 0.05)， with 80 μmol/g protein FA mitigating 67.85% loss in digestibility. Overall， FA effectively preserved the release of peptides by inhibiting hydrophobic aggregation and oxidation of lysine residues， thereby alleviating the decrease in digestibility of oxidized MP.

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Oyster-derived Anticoagulant Peptide Mitigates Thrombin-induced Barrier Dysfunction and Prothrombotic Phenotype in Human Pulmonary Microvascular Endothelial Cells

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food Science and Human Wellness 2024年

作者： Shuzhen Cheng Siyi Wang Ximing Yang Minghao Xie Qi Yang Lushun Yuan Ming Du SKL of Marine Food Processing & Safety Control， School of Food Science and Technology， Dalian Polytechnic University National Engineering Research Center of Seafood， Collaborative Innovation Center of Seafood Deep Processing， Dalian Polytechnic University Department of Vascular Surgery， Shanghai General Hospital， Shanghai Jiao Tong University

Thrombin blockers have been shown to be effective for various pathological conditions， but their use is limited due to the potential for serious bleeding adverse effects. This study introduced a novel bioactive peptide (P-2-CG) from oyster， that mitigated thrombin-mediated barrier dysfunction and prothrombotic phenotypes in human pulmonary microvascular endothelial cells (HPMECs). P-2-CG significantly attenuated the increase in endothelial monolayer permeability induced by thrombin through the possible attenuation of RhoA activation and it promoted barrier recovery by enhancing endothelial cell adhesion. Additionally， P-2-CG was found to decrease the pro-thrombotic phenotype induced by thrombin in HPMEC by reducing the extrinsic trigger TF mRNA expression， which resulted in prolonged plasma clotting time， decreased FXa activation， and reduced thrombin generation. Moreover， P-2-CG inhibited thrombosis efficiently by blocking ICAM-1 and VCAM-1 expression via tyrosine phosphorylation of RelA/p65. P-2-CG inhibits thrombin mediated inflammation and provides a potential therapeutic option for treating endothelial dysfunction and thrombosis.

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Structural analysis of a neutral polysaccharide ATP-1 from the red seaweed Asparagopsis taxiformis and its immunomodulatory effects on RAW264.7 macrophages

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food Science and Human Wellness 2025年

作者： Kun Yang Baojun Xu Wei Hu Yifan Tang Amy Hui-Mei Lin Saiyi Zhong College of Food Science and Technology， Guangdong Ocean University， Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety，Guangdong Province Engineering Laboratory for Marine Biological Products， Guangdong Provincial Engineering Technology Research Center of Seafood Guangdong Provincial Engineering Technology Research Center of Prefabricated Seafood Processing and Quality Control Food Science and Technology Program， Department of Life Sciences， BNU-HKBU United International College Singapore Institute of Food and Biotechnology Innovation (SIFBI) Shenzhen Research Institute， Guangdong Ocean University

As a seaweed supplement， the powdered， entire herb of Asparagopsis taxiformis can effectively promote immune response in animals. However， the active factors responsible for this effect are currently unknown. A novel polysaccharide， ATP-1， was isolated and purified from the red alga A. taxiformis， and its structural and immunomodulatory properties were determined. ATP-1 is a neutral polysaccharide with a molecular weight of 307.978 kDa and is primarily composed of galactose (94.07%)， glucose (1.27%)， and xylose (4.66%). Scanning electron microscopy and atomic force microscopy revealed that ATP-1 had an amorphous structure and was composed of molecular chain entanglement and intramolecular hydrogen bonding interactions. The microstructure of ATP-1 exhibited asymmetric sheet–like cracks and pores. Results from immunomodulatory activity showed that ATP-1 promoted inducible nitric oxide (NO) synthase and cyclooxygenase (COX)-2 protein expression in RAW264.7 macrophages， improved macrophage phagocytic ability， and stimulated cytokine production (NO， tumor necrosis factor [TNF]-α， and interleukin [IL]-6). Quantitative proteome analysis identified 178 differentially expressed proteins (70 upregulated and 108 downregulated) that were involved in various molecular pathways， among which， TNF was one of the 20 most common and significant signaling pathways in inflammation and immunoregulation. Western blotting indicated that ATP-1 significantly upregulated the expression of IKKα， IKKβ， COX-2， and TNF-α proteins in the TNF pathway. In contrast， ATP-1 downregulated the expression of IκBα， Fas， and AIPI. Results from molecular docking suggested that hydrogen bonding predominantly contributed to the affinity between TNF-α and galactose， glucose， and xylose. These findings indicated that ATP-1 may play an immunomodulatory role by activating the TNF signaling pathway. ATP-1 enhanced macrophage phagocytic capacity and stimulated the production of cytokines NO， TNF-α， and IL-6， thereb

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Effects of oxidation and precursors(lysine,glyoxal and Schiff base)on the formation of Nε-carboxymethyl-lysine in aged,stored and thermally treated chicken meat

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food Science and Human Wellness 2022年第5期11卷 1252-1258页

作者： Suhong Huang Xiaoli Dong Yulong Zhang Ming Huang Yuandong Zheng Jiangsu Collaborative Innovation Center of Meat Production and Processing Quality and Safety ControlCollege of Food Science and TechnologyNanjing Agricultural UniversityNanjing 210095China Jiangsu Province Research Engineering Center for Livestock and Poultry Meat Processing National R&D Center for Poultry Processing TechnologyNanjing Huangjiaoshou Food Science and Technology Co.Ltd.Nanjing 210095China Henan Province Qi County Yongda Food Industry Co. Ltd.Hebi 458000China

Advanced glycation end products(AGEs)might pose health risks,and processing and storage could accelerate the generation of AGEs in ***,limited few reports indicated the changes of AGEs contents in meat during *** this study,the aim is to investigate the oxidation and precursors and their roles in the formation of N^(ε)-carboxymethyl-lysine(CML)in raw and cooked chicken meat after post-mortem ageing and *** post-mortem ageing and storage time increased,the CML content in cooked chicken breast significantly increased from 1.81 mg/kg to 2.00 mg/kg during 0-6 h,and then decreased from 2.00 mg/kg to 1.80 mg/kg during 6 h-1 day,finally increased again during 1-7 days,while the CML contents of raw and cooked leg significantly and continuously increased from 1.78 mg/kg to 2.08 mg/***,CML was extremely positively correlated with fat oxidation(R^(2)=0.793,P<0.01),protein oxidation(R^(2)=0.917,P<0.01)and glyoxal(R^(2)=0.678,P<0.05),and was negatively correlated with lysine(R^(2)=0.536,P<0.05).No significant correlation was observed between the Schiff base and CML.

关键词： Nε-carboxymethyl-lysine Chicken Post-mortem ageing Storage Oxidation Precursors

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Effects of soy hull polysaccharide on dyslipidemia and pathoglycemia in rats induced by a high-fat-high-sucrose diet

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food Science and Human Wellness 2022年第1期11卷 49-57页

作者： Qian Lin Lina Yang Lin Han Ziyi Wang Mingshuo Luo Danshi Zhu He Liu Xin Li Yu Feng College of Food Science and Technology Bohai UniversityJinzhou 121013China National&Local Joint Engineering Research Center of Storage Processing and Safety Control Technology for Fresh Agricultural and Aquatic ProductsJinzhou 121013China

The present work aimed at investigating the effects of soy hull polysaccharide(SHP)in alleviating adverse effects in rats fed a high-fat-high-sucrose *** SHP feeding for 4 weeks,the fasting blood glucose(FBG),serum triglyceride(TG),serum high-density lipoprotein cholesterol(HDL-C),short chain fatty acids(SCFAs),and 16S rDNA gene sequence were *** of SHP significantly decreased body fat content and TG levels,and increased water intake and HDL-C levels after 4 weeks of *** antihyperglycemic effect of SHP at a dose of 400 mg/kg mb had the most significant effects among the three dosage *** notably restored the FBG in rats fed a high-fat-high-sucrose diet(P<0.05).Furthermore,SHP at 400 mg/kg mb increased the abundance of Bacteroidetes and decreased that of Firmicutes and Actinobacteria at the phylum *** polysaccharide treated groups had significantly higher content of total SCFAs,and the main fermentation products were acetic,propionic,n-valeric and i-valeric ***,SHP restores blood lipid levels in rats fed a high-fat-high sucrose diet through regulation of the gut microbiota.

关键词： Soy hull polysaccharide Antihyperlipidemic Gut microbiota Short-chain fatty acids

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Corrigendum to ‘regulation of corn starch on the properties of tremella polysaccharide-egg white protein-orange juice composite gel and its application in 3D printing’ [food chemistry: X 27 (2025) 102382] (food Chemistry: X (2025) 27, (S2590157525002299), (10.1016/***.2025.102382))

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food Chemistry: X 2025年 27卷 102449页

作者： Liu, Lili Shao, Beibei Yang, Wanlin Cheng, Weiwei Ding, Yue Xiao, Feng College of Food and Bioengineering National Experimental Teaching Demonstration Center for Food Processing and Security Henan Engineering Technology Research Center of Food Raw Materials International Joint Laboratory of Food Processing and Quality Safety Control of Henan Province Henan Engineering Technology Research Center of Food Microbiology Henan University of Science and Technology Luoyang471023 China School of instrument Science and Opto-Electronics Engineering Beijing Information Science and Technology University Beijing100192 China

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Construction and Characteristics of Epigallocatechin Gallate-Porcine Serum Albumin Pickering Emulsion: Based on Multi-Spectroscopic Analysis

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SSRN 2024年

作者： Liu, Lili Zhang, Xiaodan Xiao, Feng Wang, Yuantu Chen, Weiwei Su, Kenan Yu, Ying Yang, Xieli Cheng, Weiwei Xu, Baocheng College of Food and Bioengineering National Experimental Teaching Demonstration Center for Food Processing and Security Henan Engineering Technology Research Center of Food Raw Materials International Joint Laboratory of Food Processing and Quality Safety Control of Henan Province Henan Engineering Technology Research Center of Food Microbiology Henan University of Science and Technology Luoyang471023 China College of Lizheng Henan University of Science and Technology Luoyang471023 China Henan University of Science and Technology China

Pickering emulsion prepared by the interaction between polyphenols and protein can improve the stability of protein-based emulsion. The purpose of this study was to explore the complex formation mechanism of epigallocatechin gallate (EGCG)-porcine serum albumin (PSA) complex and the preparation of food-grade Pickering emulsion. By the UV and fluorescence spectral analysis, it was found that EGCG has an obvious fluorescence quenching effect on PSA, mainly static quenching. The results of synchronous, three-dimensional fluorescence and FT-IR spectroscopy showed that the hydrophobic microenvironment of aromatic amino acids and the secondary structure of PSA changed after EGCG was added. The results of molecular docking examined that EGCG and PSA form more stable complexes due to hydrogen bonds, and the binding energy was -4.43 kcal /mol. Compared with the PSA emulsion, the successfully prepared EGCG-PSA Pickering emulsion had smaller droplets and no obvious color in CLMS. The Pickering emulsion of EGCG-PSA had strong emulsification and high viscosity, which belonged to pseudoplastic non-Newtonian fluid. In addition, the free fatty acids release rate of EGCG-PSA Pickering emulsion was decreased by 9.9%. The antioxidant performance of the EGCG-PSA Pickering emulsion was improved, and the DPPH radical scavenging rate and the ABTS+ radical scavenging rate reached the highest, which were 93.72% and 57.16% respectively. This study provides important insights into the interaction between EGCG and PSA, and a reference for the development of polyphenol-protein complex Pickering emulsion in food, medicine, cosmetics, and other fields. © 2024, The Authors. All rights reserved.

关键词： Proteins

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Oyster Protein Hydrolysate Alleviates Cadmium Toxicity by Restoring Cadmium-Induced Intestinal Damage and Gut Microbiota Dysbiosis in Mice via Its Abundance of Methionine,Tyrosine,and Glutamine

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Biomedical and Environmental Sciences 2022年第7期35卷 669-673页

作者： WANG Jing Wen FANG Zhi Jia LI Yong Bin HUANG Lin Ru SUN Li Jun LIU Ying WANG Ya Ling LIAO Jian Meng College of Food Science and Technology Guangdong Provincial Key Laboratory of Aquatic Product Processing and SafetyGuangdong Provincial Engineering Technology Research Center of Marine FoodKey Laboratory of Advanced Processing of Aquatic Products of Guangdong Higher Education InstitutionGuangdong Ocean UniversityZhanjiang 524088GuangdongChina Institute for Food and Drug Control Zhanjiang 524088GuangdongChina

As a typical heavy metal contaminant in food,cadmium(Cd)easily enters the human food chain via crop production,and therefore,threatens human health[1].Intestinal absorption is the principal route for Cd entry into the body,and therefore,intestinal tissue become the primary target for Cd toxicity[2].Previous studies showed that acute Cd exposure damaged intestinal tight junctions,resulting in gut barrier destruction and alterations in gut microbiota[3].Thus,the effective prevention of Cd-induced intestinal damage has become a major research challenge.

关键词： prevention alterations cadmium

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Oyster-derived anticoagulant peptide mitigates thrombin-induced barrier dysfunction and prothrombotic phenotype in human pulmonary microvascular endothelial cells

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food Science and Human Wellness 2025年第5期14卷 1854-1863页

作者： Shuzhen Cheng Siyi Wang Ximing Yang Minghao Xie Qi Yang Lushun Yuan Ming Du SKL of Marine Food Processing&Safety Control School of Food Science and TechnologyDalian Polytechnic UniversityDalian 116034China National Engineering Research Center of Seafood Collaborative Innovation Center of Seafood Deep ProcessingDalian Polytechnic UniversityDalian 116034China Department of Vascular Surgery Shanghai General HospitalShanghai Jiao Tong UniversityShanghai 201620China

Thrombin blockers have been shown to be effective for various pathological conditions,but their use is limited due to the potential for serious bleeding adverse *** study introduced a novel bioactive peptide(P-2-CG) from oyster,that mitigated thrombin-mediated barrier dysfunction and prothrombotic phenotypes in human pulmonary microvascular endothelial cells(HPMECs).P-2-CG significantly attenuated the increase in endothelial monolayer permeability induced by thrombin through the possible attenuation of RhoA activation and it promoted barrier recovery by enhancing endothelial cell ***,P-2-CG was found to decrease the pro-thrombotic phenotype induced by thrombin in HPMEC by reducing the extrinsic trigger tissue factor mRNA expression,which resulted in prolonged plasma clotting time,decreased Factor Xa activation,and reduced thrombin ***,P-2-CG inhibited thrombosis efficiently by blocking intercellular adhesion molecule 1 and vascular cell adhesion protein 1 expression via tyrosine phosphorylation of nuclear factor-κB p65.P-2-CG inhibits thrombin mediated inflammation and provides a potential therapeutic option for treating endothelial dysfunction and thrombosis.

关键词： Thrombin Bioactive peptide Prothrombotic phenotype Barrier function Adhesion molecules

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