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Simultaneous Application of Photothermal Therapy and an Anti‐inflammatory Prodrug using Pyrene–Aspirin‐Loaded Gold Nanorod Graphitic Nanocapsules

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Angewandte Chemie 2017年第1期130卷

作者： Qian Dong Xuewei Wang Xiaoxiao Hu Langqiu Xiao Liang Zhang Lijuan Song Minglu Xu Yuxiu Zou Long Chen Zhuo Chen Weihong Tan Molecular Science and Biomedicine Laboratory (MBL) State Key Laboratory of Chemo/Bio-Sensing and Chemometrics College of Chemistry and Chemical Engineering Aptamer Engineering Center of Hunan Province Hunan University Changsha Hunan 410082 China College of Life Sciences Molecular Science and Biomedicine Laboratory (MBL) State Key Laboratory of Chem/Bio-Sencing and Chemometrics Aptamer Engineering Center of Hunan Province Hunan University Changsha Hunan 410082 China Faculty of Science and Technology University of Macau E11 Avenida da Universidade Taipa 999078 Macau Department of Chemistry and Department of Physiology and Functional Genomics Center for Research at Bio/nano Interface Health Cancer Center UF Genetics Institute and McKnight Brain Institute University of Florida Gainesville FL 32611-7200 USA

Photothermal therapy (PTT) has been extensively developed as an effective approach against cancer. However, PTT can trigger inflammatory responses, in turn simulating tumor regeneration and hindering subsequent therapy. A therapeutic strategy was developed to deliver enhanced PTT and simultaneously inhibit PTT‐induced inflammatory response. 1‐Pyrene methanol was utilize to synthesize the anti‐inflammatory prodrug pyrene–aspirin (P‐aspirin) with a cleavable ester bond and also facilitate loading the prodrug on gold nanorod (AuNR)‐encapsulated graphitic nanocapsule (AuNR@G), a photothermal agent, through π–π interactions. Such AuNR@G‐P‐aspirin complexes were used for near‐infrared laser‐triggered photothermal ablation of solid tumor and simultaneous inhibition of PTT‐induced inflammation through the release of aspirin in tumor milieu. This strategy showed excellent effects in vitro and in vivo.

关键词： Aspirin Entzündungen Graphitische Nanokapseln Photothermaltherapie Prodrugs

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Who can benefit more from its twelve-week treatment:A prospective cohort study of blonanserin for patients with schizophrenia

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World Journal of Psychiatry 2024年第11期14卷 1735-1745页

作者： Bao-Yan Xu Kun Jin Hai-Shan Wu Xue-Jun Liu Xi-Jin Wang Hong Sang Ke-Qing Li Mei-Juan Sun Hua-Qing Meng Huai-Li Deng Zhi-Yuan Xun Xiao-Dong Yang Lin Zhang Guan-Jun Li Rui-Ling Zhang Duan-Fang Cai Jia-Hong Liu Gui-Jun Zhao Long-Fa Liu Gang Wang Chang-Lie Zhao Bin Guo Sheng-Chun Jin Ling-Yun Huang Fu-De Yang Jian-Min Zheng Gui-Lai Zhan Mao-Sheng Fang Xiang-Jun Meng Guang-Ya Zhang Hai-Min Li Xiang-Lai Liu Ju-Hong Li Bin Wu Hai-Yun Li Jin-Dong Chen Department of Psychiatry National Clinical Research Center for Mental DisordersNational Center for Mental DisordersThe Second Xiangya Hospital of Central South UniversityChangsha 410011Hunan ProvinceChina Department of Psychiatry Hebei Provincial Mental Health CenterHebei Key Laboratory of Major Mental and Behavioral DisordersThe Sixth Clinical Medical College of Hebei UniversityBaoding 071000Hebei ProvinceChina Department of Psychiatry Brain Hospital of Hunan ProvinceChangsha 410000Hunan ProvinceChina Department of Psychiatry The First Psychiatric Hospital of HarbinHarbin 150000Heilongjiang ProvinceChina Mental Health Center Changchun Sixth HospitalChangchun 130000Jilin ProvinceChina Department of Pharmacy Daqing Third HospitalDaqing 163000Heilongjiang ProvinceChina Department of Physical and Psychological Rehabilitation Guangda Rehabilitation HospitalChongqing 400000China Department of Psychology Shanxi Provincial Mental Health CenterTaiyuan 030000Shanxi ProvinceChina Department of Psychiatry Tianjin Anding HospitalTianjin 300000China Department of Psychiatry Shandong Mental Health CenterJinan 250000Shandong ProvinceChina Department of Psychiatry Fuzhou Shenkang HospitalFuzhou 350000Fujian ProvinceChina Department of Psychiatry Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghai 200000China Department of Psychiatry The Second Affiliated Hospital of Xinxiang Medical UniversityXinxiang 453000Henan ProvinceChina Department of Psychiatry The Fifth People’s Hospital of ZigongZigong 643000Sichuan ProvinceChina Department of Psychiatry The Affiliated Kangning Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina Department of Psychiatry Guangyuan Mental Health CenterGuangyuan 628000Sichuan ProvinceChina Department of Psychiatry Jilin Sixth People’s HospitalJilin 132000Jilin ProvinceChina The National Clinical Research Center for Mental Disorders&Beijing Key Laboratory of Mental Disorders Beijing Anding Hospital

BACKGROUND Blonanserin(BNS)is a well-tolerated and effective drug for treating *** To investigate which types of patients would obtain the most benefit from BNS *** A total of 3306 participants were evaluated in a 12-week,prospective,multicenter,open-label post-marketing surveillance study of *** psychiatric rating scale(BPRS)scores were calculated to evaluate the effectiveness of BNS,and its safety was assessed with the incidence of adverse drug *** regression was used to screen the influencing factors for the reduction of BPRS total score,and logistic regression was used to identify patients with a better response to *** The baseline BPRS total score(48.8±15.03)decreased to 27.7±10.08 at 12 weeks(P<0.001).Extrapyramidal symptoms(14.6%)were found to be the most frequent adverse drug *** acute phase,baseline BPRS total score,current episode duration,number of previous episodes,dose of concomitant antipsychotics,and number of types of sedative-hypnotic agents were found to be independent factors affecting the reduction of BPRS total score after treatment ***,patients in the acute phase with baseline BPRS total score≥45,current episode duration<3 months,and≤3 previous episodes derived greater benefit from 12-week treatment with *** Patients in the acute phase with more severe symptoms,shorter current episode duration,fewer previous episodes,and a lower psychotropic drug load derived the greatest benefit from treatment with BNS.

关键词： Schizophrenia Blonanserin Effectiveness Psychosocial functioning Prospective cohort study

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An Aptamer Cross‐Linked Hydrogel as a Colorimetric Platform for Visual Detection†

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Angewandte Chemie 2010年第6期122卷

作者： Zhi Zhu Cuichen Wu Haipeng Liu Yuan Zou Xiaoling Zhang Huaizhi Kang Chaoyong James Yang Weihong Tan Center For Research at Bio/nano Interface Department of Chemistry and Department of Physiology and Functional Genomics Shands Cancer Center UF Genetics Institute and McKnight Brain Institute University of Florida Gainesville FL 32611‐7200 (USA) Fax: (+1) 352‐846‐2410 State Key Laboratory for Physical Chemistry of Solid Surfaces The Key Laboratory for Chemical Biology of Fujian Province and Department of Chemical Biology College of Chemistry and Chemical Engineering Xiamen University Xiamen 361005 (China) Fax: (+86) 592‐218‐9959 Department of Chemistry School of Science Beijing Institute of Technology Beijing 100081 (China) Biomedical Engineering Center State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical Engineering Hunan University Changsha 410082 (China)

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Near-Infrared Aggregation-Induced Emission Luminogens for In Vivo Theranostics of Alzheimer's Disease

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Angewandte Chemie 2022年第2期135卷

作者： Dr. Tianfu Zhang Xiaoyu Chen Dr. Congmin Yuan Prof. Xiaobin Pang Ping Shangguan Yisheng Liu Lulu Han Prof. Jianwei Sun Dr. Jacky W. Y. Lam Dr. Yang Liu Dr. Jiefei Wang Prof. Bingyang Shi Prof. Ben Zhong Tang Department of Chemistry the Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction Division of Life Science and State Key Laboratory of Molecular Neuroscience The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong China Contribution: Conceptualization (lead) Methodology (lead) Writing - original draft (lead) Writing - review & editing (lead) Henan-Macquarie University Joint Centre for Biomedical Innovation School of Life Sciences Henan University 475004 Kaifeng China Contribution: Methodology (equal) Contribution: Methodology (supporting) Software (supporting) Henan Key Laboratory of Brain Targeted Bio-nanomedicine School of Life Sciences & School of Pharmacy Henan University 475004 Kaifeng China Contribution: Methodology (supporting) Contribution: Writing - review & editing (supporting) Contribution: Supervision (supporting) Writing - review & editing (supporting) Contribution: Funding acquisition (supporting) Methodology (supporting) Supervision (equal) Writing - review & editing (equal) Centre for motor neuron disease Macquarie Medical School Faculty of Medicine & Health Sciences Macquarie University Sydney NSW Australia Contribution: Funding acquisition (equal) Supervision (equal) Writing - review & editing (equal) School of Science and Engineering Shenzhen Institute of Aggregate Science and Technology The Chinese University of Hong Kong 518172 Shenzhen Guangdong China Contribution: Funding acquisition (lead) Project administration (lead) Supervision (lead) Writing - review & editing (equal)

Optimized theranostic strategies for Alzheimer's disease (AD) remain almost absent from bench to clinic. Current probes and drugs attempting to prevent β-amyloid (Aβ) fibrosis encounter failures due to the blood–brain barrier (BBB) penetration challenge and blind intervention time window. Herein, we design a near-infrared (NIR) aggregation-induced emission (AIE) probe, DNTPH, via balanced hydrophobicity-hydrophilicity strategy. DNTPH binds selectively to Aβ fibrils with a high signal-to-noise ratio. In vivo imaging revealed its excellent BBB permeability and long-term tracking ability with high-performance AD diagnosis. Remarkably, DNTPH exhibits a strong inhibitory effect on Aβ fibrosis and promotes fibril disassembly, thereby attenuating Aβ-induced neurotoxicity. DNTPH treatment significantly reduced Aβ plaques and rescued learning deficits in AD mice. Thus, DNTPH serves as the first AIE in vivo theranostic agent for real-time NIR imaging of Aβ plaques and AD therapy simultaneously.

关键词： Aggregation-Induced Emission Alzheimer's Disease Near-Infrared Theranostic β-Amyloid

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Expert consensus on the diagnosis and treatment of solid tumors with BRAF mutations

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The Innovation 2024年第6期5卷 100-116页

作者： Wenxian Wang Bin Lian Chunwei Xu Qian Wang Ziming Li Nan Zheng Aijun Liu Jinpu Yu Wenzhao Zhong Zhijie Wang Yongchang Zhang Jingjing Liu Shirong Zhang Xiuyu Cai Anwen Liu Wen Li Lili Mao Ping Zhan Hongbing Liu Tangfeng Lv Liyun Miao Lingfeng Min Yu Chen Jingping Yuan Feng Wang Zhansheng Jiang Gen Lin Long Huang Xingxiang Pu Rongbo Lin Weifeng Liu Chuangzhou Rao Dongqing Lv Zongyang Yu Xiaoyan Li Chuanhao Tang Chengzhi Zhou Junping Zhang Junli Xue Hui Guo Qian Chu Rui Meng Xuewen Liu Jingxun Wu Rui Zhang Jin Zhou Zhengfei Zhu Yongheng Li Hong Qiu Fan Xia Yuanyuan Lu Xiaofeng Chen Jian Feng Rui Ge Enyong Dai Yu Han Weiwei Pan Fei Pang Xin Huang Meizhen Hu Qing Hao Kai Wang Fan Wu Binbin Song Bingwei Xu Liping Wang Youcai Zhu Li Lin Yanru Xie Xinqing Lin Jing Cai Ling Xu Jisheng Li Xiaodong Jiao Kainan Li Jia Wei Huijing Feng Lin Wang Yingying Du Wang Yao Xuefei Shi Xiaomin Niu Dongmei Yuan Yanwen Yao Jianhui Huang Yue Feng Yinbin Zhang Pingli Sun Hong Wang Mingxiang Ye Dong Wang Zhaofeng Wang Yue Hao Zhen Wang Bin Wan Donglai Lv Shengjie Yang Jin Kang Jiatao Zhang Chao Zhang Wenfeng Li Jianfei Fu Lizhi Wu Shijie Lan Juanjuan Ou Lin Shi Zhanqiang Zhai Yina Wang Bihui Li Zhang Zhang Ke Wang Xuelei Ma Zhongwu Li Zhefeng Liu Nong Yang Lin Wu Huijuan Wang Gu Jin Guansong Wang Jiandong Wang Hubing Shi Meiyu Fang Yong Fang Yuan Li Xiaojia Wang Jing Chen Yiping Zhang Xixu Zhu Yi Shen Shenglin Ma Biyun Wang Yong Song Zhengbo Song Wenfeng Fang Yuanzhi Lu Lu Si Department of Chemotherapy Chinese Academy of Sciences University Cancer Hospital(Zhejiang Cancer Hospital)HangzhouZhejiang 310022P.R.China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Melanoma and SarcomaPeking University Cancer Hospital&InstituteBeijing 100142P.R.China Institute of Cancer and Basic Medicine(ICBM) Chinese Academy of SciencesHangzhouZhejiang 310022P.R.China Department of Respiratory Medicine Affiliated Jinling HospitalMedical School of Nanjing UniversityNanjingJiangsu 210002P.R.China Department of Respiratory Medicine Affiliated Hospital of Nanjing University of Chinese MedicineJiangsu Province Hospital of Chinese MedicineNanjingJiangsu 210029P.R.China Department of Shanghai Lung Cancer Center Shanghai Chest HospitalShanghai Jiao Tong UniversityShanghai 200030P.R.China Beijing Key Laboratory of Mental Disorders National Clinical Research Center for Mental Disorders&National Center for Mental DisordersBeijing Anding HospitalCapital Medical UniversityBeijing 200030China Advanced Innovation Center for Human Brain Protection Capital Medical UniversityBeijing 200030China Senior Department of Pathology the 7th Medical Center of PLA General HospitalBeijing 100700P.R.China Department of Cancer Molecular Diagnostics Core Tianjin Medical University Cancer Institute and HospitalTianjin 300060P.R.China Guangdong Lung Cancer Institute Guangdong Provincial Laboratory of Translational Medicine in Lung CancerGuangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesSchool of MedicineGuangzhouGuangdong 510080P.R.China State Key Laboratory of Molecular Oncology Department of Medical OncologyNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021P.R.China Department of Medical Oncology Lung Cancer and Gastrointestinal UnitHunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School

The BRAF gene is an important signaling molecule in human cells that is involved in the regulation of cell growth,differentiation,and *** the BRAF gene mutates,it can lead to abnormal activation of the signaling pathway,which promotes cell proliferation,inhibits cell apoptosis,and ultimately contributes to the occurrence and development of *** mutations are widely present in various cancers,including malignant melanoma,thyroid cancer,colorectal cancer,non-small cell lung cancer,and hairy cell leukemia,among *** is an important target for the treatment of various solid tumors,and targeted combination therapies,represented by BRAF inhibitors,have become one of the main treatment modalities for a variety of BRAF-mutation-positive solid tumors.

关键词： BRAF diagnosis treatment

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Target-specificity of different amyrin subunits in impeding HCV influx mechanism inside the human cells considering the quantum tunnel profiles and molecular strings of the CD81 receptor: a combined in silico and in vivo study

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In silico pharmacology 2023年第1期11卷 8页

作者： Anika Jabin Mohammad Fahim Uddin Salauddin Al Azad Ashfaque Rahman Fawzia Tabassum Pritthy Sarker A K M Helal Morshed Samiur Rahman Fatima Fairuz Raisa Musfiqur Rahman Sakib Abeer Hasan Olive Tabassum Islam Ramisha Tahsin Shahlaa Zernaz Ahmed Partha Biswas Mst Umme Habiba Mahbuba Siddiquy Maryam Jafary Department of Biochemistry and Microbiology North South University Dhaka 1229 Bangladesh. College of Material Science and Engineering Zhejiang Sci-Tech University Hangzhou 310018 Zhejiang People's Republic of China. Key Laboratory of Industrial Biotechnology Ministry of Education School of Biotechnology Jiangnan University Wuxi 214122 Jiangsu Province People's Republic of China. Department of Genetic Engineering and Biotechnology Shahjalal University of Science and Technology Sylhet 3114 Bangladesh. Pathology and Pathophysiology Major Academy of Medical Science Zhengzhou University Zhengzhou City 450001 Henan Province People's Republic of China. Department of Electrical and Electronic Engineering Brac University Dhaka 1212 Bangladesh. Department of Pharmacy Bangabandhu Sheikh Mujibur Rahman Science and Technology University Gopalganj 8100 Bangladesh. Department of Pharmacy East West University Dhaka 1212 Bangladesh. Department of Computer Science and Engineering East West University Dhaka 1212 Bangladesh. Department of Pharmaceutical Sciences North South University Dhaka 1229 Bangladesh. Department of Genetic Engineering and Biotechnology Jashore University of Science and Technology Jashore 7408 Bangladesh. Data Science Research Unit RPG Interface Lab Jashore 7400 Bangladesh. State Key Laboratory of Food Science and Technology Jiangnan University Wuxi 214122 Jiangsu Province People's Republic of China. Division of Food Safety and Hygiene Department of Environmental Health Engineering School of Public Health Tehran University of Medical Sciences Tehran *** Iran.

HCV is a hepatotropic RNA virus recognized for its frequent virulence and fatality worldwide. Despite many vaccine development programs underway, researchers are on a quest for natural bioactive compounds due to their multivalent efficiencies against viral infections, considering which the current research aimed to figure out the target-specificity and therapeutic potentiality of α, β, and δ subunits of amyrin, as novel bioactive components against the HCV influx mechanism. Initially, the novelty of amyrin subunits was conducted from 203 pharmacophores, comparing their in-silico pharmacokinetic and pharmacodynamic profiles. Besides, the best active site of CD81 was determined following the quantum tunneling algorithm. The molecular dynamic simulation was conducted (100 ns) following the molecular docking steps to reveal the parameters- RMSD (Å); Cα; RMSF (Å); MolSA (Å); Rg (nm); PSA (Å); SASA (Å), and the MM-GBSA dG binding scores. Besides, molecular strings of CD81, along with the co-expressed genes, were classified, as responsible for encoding CD81-mediated protein clusters during HCV infection, resulting in the potentiality of amyrins as targeted prophylactics in HCV infection. Finally, in vivo profiling of the oxidative stress marker, liver-specific enzymes, and antioxidant markers was conducted in the DMN-induced mice model, where -amyrin scored the most significant values in all aspects.

关键词： CD81 receptor Co-expressed genes behind HCV invasion DMN-induced hepatic fibrosis HCV infection In-silico pharmacokinetics and pharmacodynamics Target-specificity of amyrins

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FOUR NOVEL SUSCEPTIBILITY VARIANTS IDENTIFIED IN CHINESE ARE ASSOCIATED WITH SPORADIC ALZHEIMER’S DISEASE

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Alzheimer's & Dementia 2017年第7期13卷 P189-P191页

作者： Jianping Jia Xianbo Zuo Ling Wei Cuibai Wei Kai Wang Luxi Shen Fangyu Li Wei Qin Yi Tang Dantao Peng Lan Tan Benyan Luo Qihao Guo Yong Ji Muni Tang Yanjiang Wang Yifeng Du Jiewen Zhang Junjian Zhang Qiumin Qu Longfei Jia Center of Alzheimer's Disease Beijing Institute for Brain Disorders Beijing China Xuan Wu Hospital Capital Medical University Beijing China Neurodegenerative Laboratory of Ministry of Education of the People’s Republic of China Beijing China Beijing Key Laboratory of Geriatric Cognitive Disorders Beijing China First Affiliated Hospital of Anhui Medical University Hefei China State Key Laboratory Incubation Base of Dermatology Ministry of National Science and Technology Hefei China China-Japan Friendship Hospital Beijing China Qingdao Municipal Hospital School of Medicine Qingdao University Qingdao China First Affiliated Hospital Zhejiang University Hangzhou China Huashan Hospital Fudan University Shanghai China Tianjin Huanhu Hospital Tianjin China Guangzhou Huiai Hospital Affiliated Hospital of Guangzhou Medical College Guangzhou China Daping Hospital Third Military Medical University Chongqing China Shandong Provincial Hospital Shandong University Jinan China Henan Provincial People's Hospital Zhengzhou China Zhongnan Hospital Wuhan University Wuhan China First Affiliated Hospital of Xi'an Jiaotong University Xi'an China Henry Ford Hospital Detroit MI USA

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Correction: Individual-specific functional connectivity markers track dimensional and categorical features of psychotic illness

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Molecular psychiatry 2020年第9期25卷 2200页

作者： Danhong Wang Meiling Li Meiyun Wang Franziska Schoeppe Jianxun Ren Huafu Chen Dost Öngür Roscoe O Brady Justin T Baker Hesheng Liu Athinoula A. Martinos Center for Biomedical Imaging Department of Radiology Massachusetts General Hospital Harvard Medical School Charlestown MA USA. Key Laboratory for NeuroInformation of Ministry of Education School of Life Science and Technology University of Electronic Science and Technology of China Chengdu China. Department of Radiology Henan Provincial People's Hospital Zhengzhou China. Psychotic Disorders Division McLean Hospital Harvard Medical School Belmont MA USA. Department of Psychiatry Beth Israel Deaconess Medical Center Harvard Medical School Boston MA USA. Psychotic Disorders Division McLean Hospital Harvard Medical School Belmont MA USA. jtbaker@***. Athinoula A. Martinos Center for Biomedical Imaging Department of Radiology Massachusetts General Hospital Harvard Medical School Charlestown MA USA. hesheng@nmr.mgh.harvard.edu. Department of Radiology Henan Provincial People's Hospital Zhengzhou China. hesheng@nmr.mgh.harvard.edu. Institute for Research and Medical Consultations Imam Abdulahman Bin Faisal University Dammam Saudi Arabia. hesheng@nmr.mgh.harvard.edu. Beijing Institute for Brain Disorders Capital Medical University Beijing China. hesheng@nmr.mgh.harvard.edu.

The original version of this article omitted the author "Roscoe O. Brady Jr." from the "Psychotic Disorders Division, McLean Hospital, Harvard Medical School, Belmont, MA, USA" and the "Depart...

The original version of this article omitted the author "Roscoe O. Brady Jr." from the "Psychotic Disorders Division, McLean Hospital, Harvard Medical School, Belmont, MA, USA" and the "Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA". This has been corrected in both the PDF and HTML versions of the article.

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MedShapeNet - A Large-Scale Dataset of 3D Medical Shapes for computer Vision

arXiv

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arXiv 2023年

作者： Li, Jianning Zhou, Zongwei Yang, Jiancheng Pepe, Antonio Gsaxner, Christina Luijten, Gijs Qu, Chongyu Zhang, Tiezheng Chen, Xiaoxi Li, Wenxuan Wodzinski, Marek Friedrich, Paul Xie, Kangxian Jin, Yuan Ambigapathy, Narmada Nasca, Enrico Solak, Naida Melito, Gian Marco Vu, Viet Duc Memon, Afaque R. Schlachta, Christopher De Ribaupierre, Sandrine Patel, Rajnikant Eagleson, Roy Chen, Xiaojun Mächler, Heinrich Kirschke, Jan Stefan de la Rosa, Ezequiel Christ, Patrick Ferdinand Li, Hongwei Bran Ellis, David G. Aizenberg, Michele R. Gatidis, Sergios Küstner, Thomas Shusharina, Nadya Heller, Nicholas Andrearczyk, Vincent Depeursinge, Adrien Hatt, Mathieu Sekuboyina, Anjany Löffler, Maximilian Liebl, Hans Dorent, Reuben Vercauteren, Tom Shapey, Jonathan Kujawa, Aaron Cornelissen, Stefan Langenhuizen, Patrick Ben-Hamadou, Achraf Rekik, Ahmed Pujades, Sergi Boyer, Edmond Bolelli, Federico Grana, Costantino Lumetti, Luca Salehi, Hamidreza Ma, Jun Zhang, Yao Gharleghi, Ramtin Beier, Susann Sowmya, Arcot Garza-Villarreal, Eduardo A. Balducci, Thania Angeles-Valdez, Diego Souza, Roberto Rittner, Leticia Frayne, Richard Ji, Yuanfeng Ferrari, Vincenzo Chatterjee, Soumick Dubost, Florian Schreiber, Stefanie Mattern, Hendrik Speck, Oliver Haehn, Daniel John, Christoph Nürnberger, Andreas Pedrosa, João Ferreira, Carlos Aresta, Guilherme Cunha, António Campilho, Aurélio Suter, Yannick Garcia, Jose Lalande, Alain Vandenbossche, Vicky Van Oevelen, Aline Duquesne, Kate Mekhzoum, Hamza Vandemeulebroucke, Jef Audenaert, Emmanuel Krebs, Claudia van Leeuwen, Timo Vereecke, Evie Heidemeyer, Hauke Röhrig, Rainer Hölzle, Frank Badeli, Vahid Krieger, Kathrin Gunzer, Matthias Chen, Jianxu van Meegdenburg, Timo Dada, Amin Balzer, Miriam Fragemann, Jana Jonske, Frederic Rempe, Moritz Malorodov, Stanislav Bahnsen, Fin H. Seibold, Constantin Jaus, Alexander Marinov, Zdravko Jaeger, Paul F. Stiefelhagen, Rainer Santos, Ana Sofia Lindo, Mariana Ferreira, André Alves, Victor Kamp, Michael Abourayya, Amr Nensa, Felix Hörst, Fabian Brehmer, Alexander Hein Girardetstraße 2 Essen45131 Germany Graz University of Technology Inffeldgasse 16c Graz8010 Austria Graz Austria The Department of Computer Science Johns Hopkins University Malone Hall 3400 N Charles St BaltimoreMD21218 United States Rte Cantonale Lausanne1015 Switzerland The Department of Measurement and Electronics AGH University of Science and Technology Krakow Poland Sierre Switzerland Department of Biomedical Engineering University of Basel Hegenheimermattweg Allschwil167C CH-4123 Switzerland The Boston College 140 Commonwealth Ave Chestnut HillMA02467 United States University Hospital B7-200 339 Windermere Road LondonN6A 5A5 Canada The Department of Radiology Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai200240 China The Research Center for Connected Healthcare Big Data ZhejiangLab Zhejiang Hangzhou311121 China The Faculty of Statistics Technical University Dortmund August-Schmidt-Straße 1 Dortmund44227 Germany The Institute of Mechanics Graz University of Technology Kopernikusgasse 24/IV Graz8010 Austria The Institute of Biomedical Manufacturing and Life Quality Engineering State Key Laboratory of Mechanical System and Vibration School of Mechanical Engineering Shanghai Jiao Tong University 800 Dongchuan Road Shanghai200240 China The Department of Cardiac Surgery Medical University Graz Auenbruggerplatz 29 Graz8036 Austria The Department of Diagnostic and Interventional Radiology University Hospital Giessen Justus-Liebig-University Giessen Klinikstraße 33 Giessen35392 Germany The Department of Mechanical Engineering Mehran University of Engineering and Technology Jamshoro Sindh76062 Pakistan The Institute of Medical Robotics Shanghai Jiao Tong University Shanghai China The Geschäftsführender Oberarzt Abteilung für Interventionelle und Diagnostische Neuroradiologie Universitätsklinikum der Technischen Universität München Ismaningerstr. 22 München81675 Germany icometrix Kolonel Be

Prior to the deep learning era, shape was commonly used to describe the objects. Nowadays, state-of-the-art (SOTA) algorithms in medical imaging are predominantly diverging from computer vision, where voxel grids, meshes, point clouds, and implicit surface models are used. This is seen from numerous shape-related publications in premier vision conferences as well as the growing popularity of ShapeNet (about 51,300 models) and Princeton ModelNet (127,915 models). For the medical domain, we present a large collection of anatomical shapes (e.g., bones, organs, vessels) and 3D models of surgical instrument, called MedShapeNet, created to facilitate the translation of data-driven vision algorithms to medical applications and to adapt SOTA vision algorithms to medical problems. As a unique feature, we directly model the majority of shapes on the imaging data of real patients. As of today, MedShapeNet includes 23 datasets with more than 100,000 shapes that are paired with annotations (ground truth). Our data is freely accessible via a web interface and a Python application programming interface (API) and can be used for discriminative, reconstructive, and variational benchmarks as well as various applications in virtual, augmented, or mixed reality, and 3D printing. Exemplary, we present use cases in the fields of classification of brain tumors, skull reconstructions, multi-class anatomy completion, education, and 3D printing. In future, we will extend the data and improve the interfaces. The project pages are: https://***/ and https://***/Jianningli/*** Codes 68T01 © 2023, CC BY.

关键词： Large dataset

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Author Correction: Sparse whole-genome sequencing identifies two loci for major depressive disorder

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Nature 2023年第7976期620卷 E28页

作者： N. A. Cai Warren Kretzschmar Yihan Li Guangyi Fu Jonathan Marchini Richard Mott Jonathan Flint Tim B. Bigdeli Mark Reimers Todd Webb Brien Riley Silviu Bacanu Roseann E. Peterson Kenneth S. Kendler Jieqin Liang Li Song Jingchu Hu Qibin Li Wei Jin Zhenfei Hu Guangbiao Wang Linmao Wang Puyi Qian Yuan Liu Tao Jiang Yao Lu Xiuqing Zhang Ye Yin Yingrui Li Xun Xu Huanming Yang Jian Wang Jun Wang Jingfang Gao Yiping Chen Hui Zhong Zhengrong Liu Gang Wang Jing Sun Hong Sang Guoqing Jiang Xiaoyan Zhou Yi Li Wei Zhang Xueyi Wang Xiang Fang Runde Pan Guodong Miao Qiwen Zhang Jian Hu Fengyu Yu Bo Du Wenhua Sang Keqing Li Guibing Chen Min Cai Lijun Yang Donglin Yang Baowei Ha Xiaohong Hong Hong Deng Gongying Li Kan Li Yan Song Shugui Gao Jinbei Zhang Zhaoyu Gan Huaqing Meng Jiyang Pan Chengge Gao Kerang Zhang Ning Sun Youhui Li Qihui Niu Yutang Zhang Tieqiao Liu Chunmei Hu Zhen Zhang Luxian Lv Jicheng Dong Xiaoping Wang Ming Tao Xumei Wang Jing Xia Han Rong Qiang He Tiebang Liu Guoping Huang Qiyi Mei Zhenming Shen Ying Liu Jianhua Shen Tian Tian Xiaojuan Liu Wenyuan Wu Danhua Gu Jianguo Shi Yunchun Chen Xiangchao Gan Lanfen Liu Lina Wang Fuzhong Yang Enzhao Cong Shenxun Shi Qi Xu Wellcome Trust Centre for Human Genetics University of Oxford Roosevelt Drive Oxford OX3 7BN UK Department of Statistics University of Oxford Oxford OX1 3TG UK East China Normal University 3663 North Zhongshan Road Shanghai 200062 China Virginia Institute for Psychiatric and Behavioral Genetics Virginia Commonwealth University Richmond 23298 Virginia USA BGI-Shenzhen Floor 9 Complex Building Beishan Industrial Zone YantianDistrict Shenzhen 518083 Guangdong China Department of Biology University of Copenhagen Ole Maal Oes Vej 5 Copenhagen 2200 Denmark Macau University of Science and Technology Avenida Wai long Taipa Macau 999078 China Taipa 999078 Macau China Princess Al Jawhara Center of Excellence in the Research of Hereditary Disorders King Abdulaziz University Jeddah 21589 Saudi Arabia Zhejiang Traditional Chinese Medical Hospital No.54 Youdian Road Hangzhou 310000 Zhejiang China CTSU Richard Doll Building University of Oxford Old Road Campus Oxford OX3 7LF UK Anhui Mental Health Center No.316 Huangshan Road Hefei 230000 Anhui China Anshan Psychiatric Rehabilitation Hospital No.127 Shuangshan Road Lishan District Anshan 114000 Liaoning China Beijing Anding Hospital of Capital University of Medical Sciences No.5 Ankang Hutong Deshengmen wai Xicheng District Beijing 100000 Beijing China Brain Hospital of Nanjing Medical University No.264 Guangzhou Road Nanjing 210000 Jiangsu China Changchun Mental Hospital No.4596 Beihuan Road Changchun 130000 Jilin China Chongqing Mental Health Center No.102 Jinzishan Jiangbei District Chongqing 404100 China Dalian No.7 Hospital No.179 Lingshui Road Ganjingzi District Dalian 116000 Liaoning China Wuhan Mental Health Center No.70 Youyi Road Wuhan 430000 Hubei China Daqing No.3 Hospital of Heilongjiang Province No.54 Xitai Road Ranghulu district Daqing 163000 Heilongjiang China First Hospital of Hebei Medical University No.89 Donggang Road Shijiazhuang 50000 Hebei China Fu

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