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Activation of IP10/CXCR3 Signaling is Highly Coincidental with PrP^(Sc)Deposition in the Brains of Scrapie-Infected Mice

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Biomedical and Environmental Sciences 2024年第11期37卷 1235-1251页

作者： Chen Jia Chen Cao Hu Chao Yang Wei Wang Lin Chen Dongdong Wu Yuezhang Shi Qi Dong Xiaoping National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases NHC Key Laboratory for Medical Virology and Viral DiseasesNational Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases Zhejiang UniversityHangzhou 100084ZhejiangChina Center for Biosafety Mega-Science Chinese Academy of SciencesWuhan 430071HubeiChina China Academy of Chinese Medical Sciences Beijing 100700China Shanghai Institute of Infectious Disease and Biosafety Shanghai 200003China

Objective To analyze the relationship between Chemokine IP10 and its receptor CXCR3 during prion *** We investigated the increases in IP10 signals,primarily localized in neurons within the brains of scrapie-infected mice,using western blotting,ELISA,co-immunoprecipitation,immunohistochemistry,immunofluorescence assays,and *** Both CXCR3 levels and activation were significantly higher in the brains of scrapie-infected mice and prion-infected SMB-S15 *** CXCR3 expression was predominantly observed in neurons and activated *** colocalization of PrPC/PrPSc with IP10/CXCR3 was observed in scrapie-infected mouse brains using immunohistochemistry and ***(IHC)analysis of whole brain sections further revealed increased accumulation of IP10/CXCR3 specifically in brain regions with higher levels of PrPSc ***-immunoprecipitation and biomolecular interaction assays revealed the molecular interactions between PrP and IP10/***,a significantly larger amount of IP10 accumulated within prion-infected SMB-S15 cells than in the normal partner cell line,***,resveratrol treatment effectively suppressed prion replication in SMB-S15 cells,thereby restoring the accumulation and secretion pattern of cellular IP10 similar to that observed in SMB-PS *** Our data demonstrate that the activation of IP10/CXCR3 signaling in prion-infected brain tissues coincides with PrPSc *** of IP10/CXCR3 signaling in the brain represents a potential therapeutic target for mitigating the progression of prion diseases.

关键词： Prion Chemokine IP10 CXCR3 Activation

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CDP-GAN:Near-Infrared and Visible Image Fusion Via Color Distribution Preserved GAN

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IEEE/CAA Journal of Automatica Sinica 2022年第9期9卷 1698-1701页

作者： Jun Chen Kangle Wu Yang Yu Linbo Luo the School of Automation Hubei Key Laboratory of Advanced Control and Intelligent Automation for Complex SystemsEngineering Research Center of Intelligent Technology for Geo-ExplorationMinistry of EducationChina University of GeosciencesWuhan 430074China the Shanghai Institute of Technical Physics Key Laboratory of Infrared System Detecting and Imaging TechnologyChinese Academy of SciencesShanghai 200083China the School of Mechanical Engineering and Electronic Information China University of GeosciencesWuhan 430074China

Dear Editor,This letter is concerned with dealing with the great discrepancy between near-infrared(NIR)and visible(VS)image fusion via color distribution preserved generative adversarial network(CDP-GAN).Different from the global discriminator in prior GAN,conflict of preserving NIR details and VS color is resolved by introducing an attention guidance mechanism into the ***。

关键词： details dealing preserving

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Influence law of different rotational speed ratios on vertical double drive rolling accuracy of large cone 10

Influence law of different rotational speed ratios on vertic...

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2024 10th International Conference on Applied Materials and Manufacturing Technology, ICAMMT 2024

作者： Song, Yanli Shen, Changrui Wang, Xuchu Wu, Kai Su, Jianjun Hubei Key Laboratory of Advanced Technology for Automotive Components Wuhan University of Technology Hubei Wuhan430070 China Hubei Collaborative Innovation Center for Automotive Components Technology Wuhan University of Technology Hubei Wuhan430070 China Hubei Research Center for New Energy & Intelligent Connected Vehicle Wuhan University of Technology Wuhan430070 China Hubei Qixing Automobile Body Co. Ltd Suizhou441300 China

In the international context of increasing tension over fossil energy, hydrogen energy has an important strategic position in the global energy structure due to its advantages of renewable, pollution-free, and high combustion efficiency. As a core component of heavy-duty chemical equipment such as hydrogen storage and hydrogen production, large cones are difficult to manufacture, and the molding accuracy is difficult to guarantee. This paper takes the vertical double-drive rolling process of large cones as the research object and reveals the influence law of different speed ratios on the axial precision error of large cones, suggesting that the axial tilt is minimized when the inner and outer speeds of the intermediate section are kept the same. © Published under licence by IOP Publishing Ltd.

关键词： Hydrogen storage

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A Time-Independent control Method for Variable-Speed Load-Bearing Walking with Suspended Backpack

A Time-Independent Control Method for Variable-Speed Load-Be...

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第43届中国控制会议

作者： Zhiyuan He Yu Cao Yifei Guo Jian Huang Hubei Key Laboratory of Brain-inspired Intelligent Systems Key Laboratory for Image Processing and Intelligent ControlSchool of Artificial Intelligence and AutomationHuazhong University of Science and Technology

ISBN: (数字)9789887581581

ISBN: (纸本)9798350366907

Walking with a load brings a significant burden to human shoulders,resulting in increasing metabolic energy consumption and the risk of skeleton and muscle *** backpack has been widely conducted for load-bearing walking,but exiting time-dependent control methods and event-based control methods are unable to exploit the characteristics of human gait *** this case,a time-independent control(TIC) method capable of eliminating the time dependence and adapting to variable speed is *** on the dynamical model of human-backpack system,an assistance profile along with the parameter optimization method are introduced which allows the backpack to reduce the burden on human shoulders during load-bearing *** the simulation evaluation,the proposed TIC method is compared with an impedance controller based time-dependent method and a locked backpack,under both constant speed and variable speed *** results demonstrates that the TIC case achieves an 89.1% reduction in dynamic load on shoulder under the condition of constant speed and a 78.2% reduction under the condition of variable speed,compared with the LOCKED case.

关键词： suspended backpack load carriage time-independent control

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Estimation and compensation of periodic disturbance using internal-model-based equivalent-input-disturbance approach

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Science China(Information Sciences) 2022年第8期65卷 150-163页

作者： Qicheng MEI Jinhua SHE Zhentao LIU Min WU School of Automation China University of Geosciences Hubei Key Laboratory of Advanced Control and Intelligent Automation for Complex Systems School of Engineering Tokyo University of Technology

This paper presents an improved equivalent-input-disturbance(EID) approach to deal with periodic disturbances. The approach has two degrees of freedom. One is an improved EID compensator, in which a repetitive controller is inserted in this study. The other is a conventional servo system for a reference *** improved EID compensator estimates and compensates for periodic disturbances without steady-state error, and the servo system ensures a satisfactory tracking performance. The improved EID compensator is designed using the linear-matrix-inequality(LMI) method. Three parameters in an LMI are selected using the particle-swarm-optimization(PSO) algorithm. The state-feedback gain of the conventional servo system is designed using the linear-quadratic-regulator(LQR) method. Simulation results of a rotational control system demonstrate the validity of the approach and its advantage over others.

关键词： equivalent input disturbance (EID) linear matrix inequality (LMI) linear quadratic regulator (LQR) particle swarm optimization (PSO) periodic disturbance repetitive control

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Optimal Portfolio of Wind-solar-hydro Hybrid Renewable Generation based on Variable Speed Pumped Storage 6

Optimal Portfolio of Wind-solar-hydro Hybrid Renewable Gener...

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6th IEEE International Electrical and Energy Conference, CIEEC 2023

作者： Xiang, Shizhe Xu, Da Gao, Menglu School of Automation China University of Geosciences Wuhan430074 China Hubei Key Laboratory of Advanced Control and Intelligent Automation for Complex Systems Wuhan430074 China Engineering Research Center of Intelligent Technology for Geo-Exploration Ministry of Education Wuhan430074 China Dc Company of State Grid Hubei Electric Power Co. Ltd. Yichang443000 China

ISBN: (纸本)9798350346671

Compared with separate solar or wind generation, the hybrid wind-solar-hydro renewable portfolio can achieve better generation characteristics due to their temporal-spatial complementarities. This paper proposes optimal portfolio of wind-solar-hydro hybrid renewable generation based on variable speed pumped storage (VSPS). In this portfolio, the complementarities of hydro-solar-wind hybrid renewable energy sources (RESs) are fully exploited via various conversion and storage devices for zero carbon 100% renewable supplies. Compared to traditional fixed speed pumped storage (FSPS), the VSPS has obvious advantages in power regulation and renewable accommodation, which is comprehensively modeled to capture its dynamic operational dispatchability and flexibility. The portfolio production, conversion, storage, and consumption are formulated via a two-stage framework, which takes the minimum system investment cost as the objective function. Case studies on southwest China are performed to show the effectiveness and superiority of the proposed methodology on cost-effective accommodation. © 2023 IEEE.

关键词： Cost effectiveness

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Multi-Level Features Fusion for Zero-Shot Object Pose Estimation 26

Multi-Level Features Fusion for Zero-Shot Object Pose Estima...

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26th International Conference on Industrial Technology, ICIT 2025

作者： Huang, Nanxin Xu, Chi School of Automation China University of Geosciences Hubei Key Laboratory of Advanced Control and Intelligent Automation for Complex Systems Engineering Research Center of Intelligent Technology for Geo-Exploration Ministry of Education Wuhan China

ISBN: (纸本)9798331521950

Driven by advancements in industrial production and artificial intelligence, the need for pose estimation of new ob-jects in areas like robotic manipulation and virtual reality is increasing. We introduce a zero-shot object pose estimation approach that identifies the poses of objects excluded from the training dataset, removing the requirement for re-modeling. The method is built around a multi-level features fusion framework de-signed to enhance generalization. First, a trainable feature extraction module filters and selects multi-level features extracted by the backbone network. Unlike traditional convolutional ker-nels, we incorporate a dynamic convolution kernel to enhance the feature extraction capability. Second, in the feature fusion module, we adopt a dynamic weight generation strategy to perform weighted fusion of multi-level features. This method enhances template matching by effectively describing similarities between unseen objects (those absent from the training set) and templates, leveraging robust and adaptive feature representations to narrow the gap with seen objects. Experimental results demonstrate that our approach achieves state-of-the-art performance on two popu-lar benchmark datasets, LineMod and LineMod-Occlusion, proves that our method has better generalization than previous models. © 2025 IEEE.

关键词： Industrial robots

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Hydrogen Purification Performance of Pressure Swing Adsorption Based on Cu-BTC/zeolite 5A Layered Bed

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Journal of Wuhan University of Technology(Materials Science) 2022年第5期37卷 815-822页

作者： SUN Kang YANG Tianqi MA Shuo YE Feng XIAO Jinsheng Hubei Research Center for New Energy&Intelligent Connected Vehicle and Hubei Key Laboratory of Advanced Technology for Automotive Components School of Automotive EngineeringWuhan University of TechnologyWuhan430070China Intelligent Manufacturing and Automobile School Chongqing College of Electronic EngineeringChongqing401331China School of Artificial Intelligence Jianghan UniversityWuhan430056China

A pressure swing adsorption (PSA) hydrogen purification model for the four-component gas (H_(2)/CO_(2)/CH_(4)/CO=73/16/8/3 mol%) in a layered bed packed with Cu-BTC and zeolite 5A was established to achieve better hydrogen purification *** comparing its simulation results with the experimental data,the adsorption isotherm model was validated and could be used to accurately describe the adsorption process of the gas mixture on the two *** breakthrough curves of the mixed gas on the layered bed were studied to verify the correctness of the established simulation *** on the validated model,the performance of the PSA system based on the layered bed was carried out,including the hydrogen purity and *** simulation results show that the hydrogen purification system based on the layered bed model can achieve hydrogen purity of 95.469% and hydrogen recovery of 83.219%.Moreover,a parametric study was carried out and its results show that reductions in feed flow rate and adsorption time result in an increase in hydrogen purity and a decrease in hydrogen recovery.A longer equalization time between the two adsorption beds can simultaneously increase the hydrogen purity and recovery.

关键词： hydrogen purification pressure swing adsorption layered bed Cu-BTC zeolite 5A

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Economic Research on User-Side Photovoltaic Energy Storage System Considering Shared Energy Storage 5

Economic Research on User-Side Photovoltaic Energy Storage S...

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5th International Conference on Power and Energy Technology, ICPET 2023

作者： Chen, Kaiwen Wang, Qingyi Kang, Kai Wang, Hao School of Automation China University of Geosciences Wuhan China Hubei Key Laboratory of Advanced Control and Intelligent Automation for Complex Systems Wuhan China Engineering Research Center of Intelligent Technology for Geo-Exploration Ministry of Education Wuhan China PowerChina Hubei Electric Engineering Co. Ltd Wuhan China Wuhan Second Ship Design and Research Institute Wuhan China

ISBN: (纸本)9798350339673

Based on the background of photovoltaic development in the whole county and the demand for energy storage on the user-side, this paper establishes an economic evaluation model of user-side photovoltaic energy storage system considering shared energy storage. Firstly, three schemes of no energy storage, independent energy storage and shared energy storage are proposed, and the influence of photovoltaic energy storage system loss on annual power generation is considered. Secondly, based on the whole life cycle theory, the cost and benefit model of the user-side photovoltaic energy storage system is established, and the unit electricity cost of the user is used as the evaluation index. Finally, the relevant data of user in hubei area are analyzed as an example to verify the effectiveness of the model and provide reference for the investment of related projects. © 2023 IEEE.

关键词： photovoltaic energy storage system shared energy storage the unit electricity cost of the user user-side

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Distributed Active Disturbance Rejection control of Multiple Mobile Robots for Online Workload Partition

Distributed Active Disturbance Rejection Control of Multiple...

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2023 China Automation Congress, CAC 2023

作者： Li, Xin Zhai, Chao Zhang, Hehong China University of Geosciences School of Automation Wuhan Campus Wuhan China Hubei Key Laboratory of Advanced Control and Intelligent Automation for Complex Systems Wuhan China Engineering Research Center of Intelligent Technology for Geo-Exploration Ministry of Education Wuhan China School of Computer and Data Science Fuzhou University Fuzhou China

ISBN: (纸本)9798350303759

Considering the actual multi-agent coverage process, the motion trajectories are seriously affected by disturbances and noise. In this paper, a cooperative control method based on active disturbance rejection controller (ADRC) for multiple mecanum-wheeled robots (MWMR) is proposed to improve its robustness. In particular, to suppress the total disturbances during the running of each robot and reduce large computation and observation cost of high order ADRC, a reduced-order cascaded ADRC (RC-ADRC) is proposed. Moreover, distributed controller is proposed to track the expected trajectories of multiple mecanum-wheeled robots under disturbances. Compared with the proposed RC-ADRC based cooperative control scheme and PID based cooperative control one, the favorable motion trajectory tracking performance is obtained. Simulation results verify the superiority of the method. © 2023 IEEE.

关键词： controllers

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