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Moderate red wine alleviates high-fat diet-induced atherosclerosis in ApoE^(-/-)mice via modulations of liver metabolism through gut microbiota remodeling

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Food Science and Human Wellness 2025年第4期14卷 1411-1423页

作者： Xuanxuan Chen Hong Yang Kaikai Li Jianhong Cao Xiaoyun Xu Siyi Pan Erhu Li College of Food Science and Technology Huazhong Agricultural UniversityWuhan 430070China Key Laboratory of Environment Correlative Dietology Ministry of EducationHuazhong Agricultural UniversityWuhan 430070China Hubei Key Laboratory of Fruit&Vegetable Processing&Quality Control Huazhong Agricultural UniversityWuhan 430070China Shangri-La Winery Co. Ltd.Diqing 674412China

Red wine has a good potential for alleviating atherosclerosis,but the mechanisms related to hepatointestinal circulation remain to be *** study showed that administration of a high-polyphenol red wine(16 mL/(kg·day))for 16 weeks significantly reduced the atherosclerotic lesion in high-fat diet-fed ApoE^(-/-)*** total cholesterol(TC)and low-density lipoprotein cholesterol(LDL-C)levels of plasma were lowered by 11.54%and 18.98%.The pro-inflammatory cytokines including interleukin-6(IL-6)and tumor necrosis factorα(TNF-α)levels were decreased by 27.59%and 31.92%.Red wine also reduced triglyceride(TG)level and lipid deposition in the liver,and increased the concentration of total bile acids(TBA).Untargeted metabolomics analysis indicated that red wine modulated the disorder of liver metabolism by regulating sphingolipid signaling pathway,sphingolipid metabolism,glycerophosphlipid metabolism,choline metabolism and bile secretion.16S rRNA sequencing revealed that red wine increased the abundance of Akkermansia and Bifidobacterium and reduced the abundance of Mucispirillum,Romboutsia,Lactobacillus,Bilophila and Blautia,along with the increased concentrations of short-chain fatty acids(SCFAs)in *** findings indicated that red wine could exert anti-atherosclerotic effect by regulating gut microbiota,restoring SCFAs,alleviating liver metabolic disorders.

关键词： Wine Atherosclerosis Gut microbiota Untargeted metabolomics Short chain fatty acids

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The ameliorative effects of ginger against heat-induced oxidative stress and mitochondrial dysfunction in Caenorhabditis elegans

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Food Science and Human Wellness 2025年

作者： Tingting Xu Mingfang Tao Rong Li Shuxin Tang Yuting Huang Ting Wu Senem Kamiloglu Siyi Pan Xiaoyun Xu Key Laboratory of Environment Correlative Dietology (Ministry of Education)， Huazhong Agricultural University Hubei Key Laboratory of Fruit & Vegetable Processing & Quality Control， Huazhong Agricultural University College of Food Science and Technology， Huazhong Agricultural University Department of Food Engineering， Faculty of Agriculture， Bursa Uludag University Science and Technology Application and Research Center (BITUAM)， Bursa Uludag University

Ginger， rich in gingerols and shogaols， exhibits multiple biological properties. However， the mechanisms underlying its thermotolerance remain unclear. The study employed network pharmacology and experimental validation in Caenorhabditis elegans to investigate how gingerol-related compounds within ginger extract (GE) mitigated damage caused by heat stress (HS). A total of 18 types of gingerol analogues were identified in GE， among which 6-， 8-， and 10-gingerol， as well as 6-， 8-， and 10-shogaol were quantified. Collectively， these six compounds accounted for 54.4% of the total composition. Supplementation with 15 μg/mL GE significantly extended heat-stress lifespan by 20.30%， while the combination of the six major gingerols and shogaols at the same concentration prolonged lifespan by 18.93%. Additionally， pretreatment with GE and the combination alleviated HS-induced oxidative damage by eliminating reactive oxygen species (ROS) and upregulating antioxidant enzymes. Network pharmacology analysis suggested that the MAPK pathway may play a crucial role in thermotolerance. Experimental findings confirmed that ginger attenuated oxidative damage through the activation of SKN-1/Nrf2 and DAF-16/FOXO via the MAPK pathway. Moreover， GE stabilized mitochondrial membrane potential and restored ATP levels， thus preserving mitochondrial function during heat exposure. Further investigations using molecular docking and molecular dynamics simulations revealed that shogaols， with more stable binding affinities for KEAP1 protein， exhibited more potent effects than gingerols in prolonging lifespan and reducing ROS levels under HS conditions. In short， gingerol analogues from ginger conferred thermal resistance to nematodes by mitigating oxidative damage and mitochondrial dysfunction.

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A promising strategy for assessing the uricosuric effect of anti-hyperuricemia candidates: a case study of caffeoylquinic acids extract of Artemisia selengensis Turcz. leaves

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Food, Nutrition and Health 2025年第1期2卷 1-12页

作者： Xiang, Lin Mansour, Mohammed Huang, Yuting Wu, Ting Pan, Siyi Xu, Xiaoyun College of Food Science and Technology Huazhong Agricultural University Wuhan China Hubei Key Laboratory of Fruit & Vegetable Processing & Quality Control Huazhong Agricultural University Wuhan China Key Laboratory of Environment Correlative Dietology (Ministry of Education) Huazhong Agricultural University Wuhan China National Key Laboratory for Germplasm Innovation & Utilization of Horticultural Crops Huazhong Agricultural University Wuhan China

Caffeoylquinic acids (CQAs) are phenolic acids found in various plants that possess multiple biological activities including anti-oxidation, anti-inflammation, and xanthine oxidase inhibitory activity. Our previous research demonstrated that CQAs-rich Artemisia selengensis Turcz. leaves extract (ASTLE) effectively lowered uric acid levels in hyperuricemia mice. However, further evidence is needed to elucidate the mechanism of the uric acid-lowering effect of ASTLE. In this study, a sensitive but non-radioactive in vitro method based on 6-carboxyfluorescein (6-CFL) was established, validated, and further applied to assess the uricosuric potential of ASTLE. Furthermore, molecular docking, qRT-PCR, and western blot were employed to evidence the uricosuric effect of ASTLE. The results demonstrated that ASTLE exhibited the potential to inhibit uric acid reabsorption, manifested as the inhibition of 6-CFL uptake by human kidney 2 (HK-2) cells (IC50 = 533.67 ± 19.91 µg/mL), and CQAs were identified as its dominant bioactive compounds. Mechanism investigation further revealed that the uptake inhibitory effect of ASTLE was attributed to the hydrogen bonding interactions of CQAs, particularly di-CQAs, with uric acid transporters URAT1 and GLUT9, as well as to the down-regulation of mRNA and protein expression of URAT1 and GLUT9 and the up-regulation of mRNA and protein expression of ABCG2 by ASTLE. This study indicated that ASTLE has potent uricosuric effect. Moreover, this study suggested that the combination of 6-CFL uptake inhibition assessment, molecular docking, qRT-PCR, and western blot analysis could be a promising strategy for revealing the role of anti-hyperuricemia candidates in promoting uric acid excretion.

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Characterization of blueberry exosome-like nanoparticles and miRNAs with potential cross-kingdom human gene targets

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Food Science and Human Wellness 2024年第2期13卷 869-878页

作者： Yangfan Leng Liubin Yang Siyi Pan Leilei Zhan Fang Yuan College of Food Science and Technology Huazhong Agricultural UniversityWuhan 430070China Hubei Key Laboratory of Fruit&Vegetable Processing&Quality Control Huazhong Agricultural UniversityWuhan 430070China Wuhan GeneCreate Biological Engineering Co. Ltd.Wuhan 430070China

Edible plant derived exosome-like nanoparticles(ELNs)have been shown to have multiple nutraceutical ***,the diversity of plant materials makes the plant derived ELN study *** efforts are still needed to explore the feasible isolation methods of edible plant derived ELNs and the possible roles of food-derived ELNs in improving human *** this study,a size exclusion chromatography based method was compared with the traditional ultracentrifugation method to isolate blueberry derived ELNs(B-ELNs),and the miRNA profile of B-ELNs was analyzed by high-throughput sequencing.A total of 36 miRNAs were found to be enriched in B-ELNs compared with berry tissue,and their potential cross-kingdom human gene targets were further *** showed that size exclusion chromatography was effective for B-ELN *** most abundant miRNAs in B-ELNs mainly belonged to the miR166 family and miR396 *** gene prediction indicated that B-ELNs could potentially regulate pathways related to the human digestive system,immune system and infectious diseases.

关键词： Edible plant derived exosomes-like nanoparticles Size exclusion chromatography miRNA Target gene prediction Blueberry

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Co-assembled C13-dipeptide hydrogels by Gallic Acid (CA) and epigallocatechin gallate (EGCG) with antibacterial activity

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Food Bioscience 2022年第5期49卷 933-940页

作者： Tan Hu Siyi Pan College of Food Science and Technology Huazhong Agricultural UniversityNo.1 Shizishan RoadWuhanHubei430070PR China Key Laboratory of Environment Correlative Dietology(Huazhong Agricultural University) Ministry of EducationChina Hubei Key Laboratory of Fruit&Vegetable Processing&Quality Control(Huazhong Agricultural University) WuhanHubei430070PR China

The self-assembled peptide-based hydrogels have been widely utilized in ***,the self-assembled hydrogels still have some shortages such as low mechanical properties and hydrogel ***,we designed two co-assembled C_(13)-WS hydrogels conjugated by Gallic Acid(CA)and Epigallocatechin Gallate(EGCG).The introduction of CA and EGCG into C_(13)-WS hydrogels can significantly improve the mechanical properties and hydrogel *** storage modulus(G’)values of co-assembled C_(13)-WS/CA and C_(13)-WS/EGCG were 13.33 KPa and 16 KPa,*** transmission electron microscope(TEM)results,CA and EGCG contributed to the rearrangement of C_(13)-WS molecules during ***,the self-/co-assembled C_(13)-WS hydrogels showed antimicrobial activity against ***,***,and *** introduction of CA and EGCG significantly enhanced the antibacterial activity of C_(13)-WS *** findings provide a novel strategy for the development of stable supramolecular antibacterial short peptide hydrogels through co-assembly.

关键词： Peptide hydrogels C_(13)-dipeptides Co-assembly Antibacterial activity

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Comprehensive widely targeted metabolomics unveils the regulatory mechanisms of high-pressure CO₂ in preserving fresh-cut water bamboo shoots (Zizania latifolia) quality

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Postharvest Biology and Technology 2025年 227卷

作者： Zhang, Jiao Wang, Haopeng Hu, Wanfeng Niaz, Nadia Zhu, Lijuan Xu, Xiaoyun Pan, Siyi College of Food Science and Technology Huazhong Agricultural University Wuhan 430070 China Key laboratory of environment correlative dietology (Huazhong Agricultural University) Ministry of Education China Hubei Key Laboratory of Fruit & Vegetable Processing & Quality Control (Huazhong Agricultural University) Hubei Wuhan 430070 China

Lignification and browning are the key factors restricting the storage quality of fresh-cut water bamboo shoots (WBS). High pressure CO2 (HPCD) treatment could mitigate lignification and browning of fresh-cut WBS. In ... 详细信息

Lignification and browning are the key factors restricting the storage quality of fresh-cut water bamboo shoots (WBS). High pressure CO₂ (HPCD) treatment could mitigate lignification and browning of fresh-cut WBS. In this study, physiological analysis and ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS)-based widely targeted metabolome analysis were conducted to explore the possible pathways through which HPCD treatment inhibits lignification and browning in WBS. The physiological analysis results showed that the respiratory rate of the HPCD-treated group was 31 % lower than that of the CK group at 10 d. HPCD treatment could inhibit respiration intensity during storage, thereby reducing weight loss and nutrient consumption, and ultimately maintaining the quality of fresh-cut WBS. In addition, the results of metabolic pathway analysis found that HPCD treatment might induce glucose to enter the glycolysis/gluconeogenesis pathway, providing a carbon skeleton, stimulating for flavonoid biosynthesis. HPCD treatment stimulated the biosynthesis of flavonoids, thereby improving the antioxidant capacity of fresh-cut WBS. Moreover, flavonoids negatively regulated the shikimic-phenylpropane pathway when they accumulate to a certain amount, inhibiting the de novo synthesis of phenolic substances, thus delaying lignification and browning. This study would provide theoretical support for the development of HPCD in postharvest preservation of fruit and vegetables that are prone to lignification and browning. © 2025

关键词： key metabolic pathways Minimally processed fruit and vegetables Non-thermal processing technology Non-volatile metabolites Postharvest quality Regulation mechanism

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Corrigendum to “Co-assembled C 13 -dipeptide hydrogels by Gallic Acid (CA) and epigallocatechin gallate (EGCG) with antibacterial activity” [Food Bioscience, 49 (2022) 101962]

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Food Bioscience 2025年 64卷

作者： Tan Hu Siyi Pan College of Food Science and Technology Huazhong Agricultural University No. 1 Shizishan Road Wuhan Hubei 430070 PR China Key Laboratory of Environment Correlative Dietology (Huazhong Agricultural University) Ministry of Education PR China Hubei Key Laboratory of Fruit & Vegetable Processing & Quality Control (Huazhong Agricultural University) Wuhan Hubei 430070 PR China

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Molecular dynamics simulation of interaction between high pressure carbon dioxide(HPCD)and phenylalanine ammonia-lyase(PAL)

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Food Bioscience 2023年第3期53卷 2847-2857页

作者： Jiaxing Li Wanfeng Hu Lijuan Zhu Ayesha Murtaza Aamir Iqbal Xiaoyun Xu Siyi Pan College of Food Science and Technology Huazhong Agricultural UniversityNo.1Shizishan StreetHongshan DistrictWuhan430070China Key Laboratory of Environment Correlative Dietology Huazhong Agricultural UniversityMinistry of EducationWuhan430070China Hubei Key Laboratory of Fruit&Vegetable Processing&Quality Control(Huazhong Agricultural University) WuhanHubei430070China College of Agriculture and Life Sciences Cornell UniversityIthacaNYUSA Department of Food Science and Technology University of Central PunjabLahorePakistan

High-pressure carbon dioxide(HPCD)could effectively suppress the yellowing phenomenon in Chinese water chestnut(CWC)by significantly inhibiting the activity of the key enzyme-phenylalanine ammonia-lyase(PAL).However,the molecular mechanism underlying this inhibition remains *** this study,we investigated the structural changes and inhibition mechanisms of PAL from CWC subjected to HPCD *** modeling was used to construct the 3D structure of CWC *** results showed that CWC PAL was highly conserved and had higherα-helix *** dynamics simulations and molecular docking were utilized to investigate the non-covalent interaction between CO_(2) and *** findings revealed that CO_(2) induced conformational changes in PAL via hydrogen bonds,polar interactions,and hydrophobic interactions,thereby increasing PAL’sα-helix structure and preventing the substrate L-Phe from entering its active ***,HPCD treatment caused the movement of the Phe-111 residue in the inner lid-loop,resulting in steric hindrance and destruction of the active center of *** results provide a theoretical basis for expanding the appli-cation of HPCD in the food processing industry.

关键词： High pressure carbon dioxide Chinese water chestnut Phenylalanine ammonia-lyase Conformational changes Molecular dynamics simulation Molecular docking

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Removal of Acetic Acid in Mulberry Wine by Co-Inoculating Saccharomyces Cerevisiae with Indigenous Non-Saccharomyces Yeast

SSRN

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SSRN 2023年

作者： Guo, Chenchen Deng, Haixia Li, Erhu College of Food Science and Technology Huazhong Agricultural University Hubei Wuhan430070 China Hubei Key Laboratory of Fruit & Vegetable Processing & Quality Control Huazhong Agricultural University Hubei Wuhan430070 China

Excessive levels of acetic acid in fruit raw materials can significantly compromise the sensory quality of the final wines. The aim of this study was to isolate non-Saccharomyces yeasts capable of metabolizing acetic acid in fruit juices, and to evaluate their enological potential in mulberry winemaking. A synthetic medium and mulberry juice were used as fermentation media, respectively. Results showed that Pichia barkeri S29 reduced the final contents of acetic acid in the synthetic medium much lower than Saccharomyces cerevisiae RV002, and addition of 2 g/L acetic acid in the synthetic medium enhanced the ethanol productivity of P. barkeri S29. In mulberry wines, P. barkeri S29 reduced roughly 43% of the acetic acid in mulberry juice, while S. cerevisiae RV002 increased the final acetic acid level by 1.4-fold. Although mixed fermentation with P. barkeri S29 and S. cerevisiae RV002 inhibited the vitality of P. barkeri S29, the concentration of acetic acid in wines declined by 65%-73% compared to pure fermentation of S. cerevisiae RV002. Furthermore, mixed fermentation boosted the variety and concentration of ester compounds, including ethyl decanoate, ethyl dodecanoate, and ethyl hexadecanoate, potentially improving the fruity flavors of mulberry wines. © 2023, The Authors. All rights reserved.

关键词： Acetic acid

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Artemisia Selengensis Turcz. Leaves Extract Ameliorates Hyperuricemia in Mice by Inhibiting Hepatic Xod Activity, Modulating Renal Uric Acid Transporters, and Regulating Organism Metabolism

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SSRN 2023年

作者： Xiang, Lin Huang, Yuting Li, Rong Tao, Yexing Wu, Ting Pan, Siyi Xu, Xiaoyun Key Laboratory of Environment Correlative Dietology Ministry of Education Hubei Key Laboratory of Fruit & Vegetable Processing & Quality Control College of Food Science and Technology Huazhong Agricultural University Wuhan430070 China

Artemisia selengensis Turcz. (AST) leaves might possess the uric acid-lowering effect due to their good in vitro xanthine oxidase (XOD) inhibitory effect. The present work aimed to further evaluate the anti - hyperuricemia (HUA) effect of AST leaves extract (ASTLE) on HUA mice and reveal its related mechanisms. Results showed that ASTLE contained ten caﬀeoylquinic acids (CQAs), totally accounting for 31.48%. In HUA mice, ASTLE reduced serum uric acid (SUA) level and increased urine uric acid (UUA) level and fraction excretion of uric acid (FEUA). Meanwhile, ASTLE protected against liver and kidney damage, as evidenced by decreased serum levels of GOT, GPT, CR, and BUN. To clarify the mechanism, analyses of hepatic XOD activity, mRNA expression of renal uric acid transporters, and serum metabonomics were carried out. After ASTLE intervention, the hepatic XOD activity was inhibited. Additionally, the mRNA expression of URAT1 and GLUT9 were down-regulated, while the mRNA expression of ABCG2, OAT1, and OAT3 were up-regulated. The results of metabonomics further suggested that ASTLE mainly regulated amino acids and their metabolites, which were involved in renal uric acid excretion function, glucose metabolism, and energy metabolism. These ﬁndings indicated that the anti - HUA effect of ASTLE could be associated with the CQAs rich in ASTLE and their capacity to inhibit the hepatic XOD activity, modulate the mRNA expression of renal uric acid transporters, and regulate metabolisms in HUA mice. In conclusion, AST leaves might be a promising resource for ameliorating HUA. © 2023, The Authors. All rights reserved.

关键词： Metabolism

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