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Meta-analysis of personal and familial co-occurrence of Attention Deficit/Hyperactivity Disorder and Bipolar Disorder

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Neuroscience and Biobehavioral Reviews 2023年第1期146卷 105050页

作者： Khoury, Elie Acquaviva, Eric Purper-Ouakil, Diane Delorme, Richard Ellul, Pierre Child and Adolescent Psychiatry Department Robert Debré Hospital APHP 48 boulevard Sérurier Paris 75019 France CHU Montpellier-Saint Eloi Hospital University of Montpellier Unit of Child and Adolescent Psychiatry (MPEA1) 80 Av. Augustin Fliche Montpellier 34090 France INSERM CESP U 1018 Psychiatry Development and Trajectories France Human Genetics and Cognitive Functions Institut Pasteur Paris France INSERM Immunology-Immunopathology-Immunotherapy (i3) UMRS 959 Paris France

Background: Attention Deficit Disorder / Hyperactivity (ADHD) and Bipolar Disorder (BD) are highly comorbid disorders. Studies have raised the hypothesis of shared genetic, neurobiological, and clinical factors. This would entail an excess risk of co-occurrence of both disorders. Objective: We present the first meta-analysis of individual and familial associations between ADHD and BD. Methods: From 2688 references, 59 were included, with a total of 550,379 ADHD patients, 57,799 BD patients and 12,608,137 controls. Results: Personal history of ADHD increased the risk of BD (OR = 6.06), and conversely individuals with BD had an increased risk of ADHD (OR = 8.94). First-degree relatives of ADHD patients had an increased risk of BD (OR = 1.94). Offspring of individuals with BD had a higher risk for ADHD (OR = 2.33). Finally, first-degree relatives of BD patients had an increased risk of ADHD (OR = 2.71). Conclusion: We show a clear epidemiological overlap between ADHD and BD, as well as a strong familial association which advocates in favor of a more systematic screening. © 2023 Elsevier Ltd

关键词： ADHD Bipolar disorder Co-occurrence Prevalence

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Decomposing the Brain in Autism: Linking Behavioral Domains to Neuroanatomical Variation and Genomic Underpinnings

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Biological Psychiatry: cognitive Neuroscience and Neuroimaging 2025年

作者： Seelemeyer, Hanna Gurr, Caroline Leyhausen, Johanna Berg, Lisa M. Pretzsch, Charlotte M. Schäfer, Tim Hermila, Bassem Freitag, Christine M. Loth, Eva Oakley, Bethany Mason, Luke Buitelaar, Jan K. Beckmann, Christian F. Floris, Dorothea L. Charman, Tony Banaschewski, Tobias Jones, Emily Bourgeron, Thomas Murphy, Declan Ecker, Christine Department of Child and Adolescent Psychiatry University Hospital Goethe University Frankfurt Frankfurt am Main Germany Brain Imaging Center Goethe University Frankfurt Frankfurt am Main Germany Department of Biosciences Goethe University Frankfurt Frankfurt am Main Germany Department of Forensic and Neurodevelopmental Sciences Institute of Psychiatry Psychology and Neuroscience King's College London London United Kingdom Fries Lab Ernst Strüngmann Institut for Neuroscience in Cooperation with Max Planck Society Frankfurt am Main Germany Department of Cognitive Neuroscience Donders Institute for Brain Cognition and Behaviour Radboud University Nijmegen Medical Center Nijmegen Netherlands Methods of Plasticity Research Department of Psychology University of Zurich Zurich Switzerland Department of Psychology Institute of Psychiatry Psychology and Neuroscience King's College London London United Kingdom Child and Adolescent Psychiatry Central Institute of Mental Health University of Heidelberg Medical Faculty Mannheim Mannheim Germany German Center for Mental Health partner site Mannheim-Heidelberg-Ulm Mannheim Germany Centre for Brain and Cognitive Development Birkbeck University of London London United Kingdom Institut Pasteur Human Genetics and Cognitive Functions Unit Paris France

Background: Autism is accompanied by highly individualized patterns of neurodevelopmental differences in brain anatomy. This variability makes the neuroanatomy of autism inherently difficult to describe at the group level. Here, we examined interindividual neuroanatomical differences using a dimensional approach that decomposed the domains of social communication and interaction (SCI), restricted and repetitive behaviors (RRBs), and atypical sensory processing (ASP) within a neurodiverse study population. Moreover, we aimed to link the resulting neuroanatomical patterns to specific molecular underpinnings. Methods: Neurodevelopmental differences in cortical thickness (CT) and surface area (SA) were correlated with SCI, RRB, and ASP domain scores by regression of a general linear model in a large neurodiverse sample of 288 autistic individuals and 140 nonautistic individuals, ages 6 to 30 years, recruited within the European Autism Interventions Longitudinal European Autism Project (EU-AIMS LEAP). The domain-specific patterns of neuroanatomical variability were subsequently correlated with cortical gene expression profiles via the Allen human Brain Atlas. Results: Across groups, behavioral variations in SCI, RRBs, and ASP were associated with interindividual differences in CT and SA in partially non-overlapping frontoparietal, temporal, and occipital networks. These domain-specific imaging patterns were enriched for genes that 1) are differentially expressed in autism, 2) mediate typical brain development, and 3) are associated with specific cortical cell types. Many of these genes were implicated in pathways governing synaptic structure and function. Conclusions: Our study corroborates the close relationship between neuroanatomical variation and interindividual differences in autism-related symptoms and traits within the general framework of neurodiversity and links domain-specific patterns of neuroanatomical differences to putative molecular underpinnings. © 2024 S

关键词： Autism spectrum disorder Autism symptoms Brain structure MRI

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F59. DISSECTING THE CONTRIBUTIONS OF RARE AND COMMON GENETIC VARIATION TO NEURODEVELOPMENTAL OUTCOMES

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European Neuropsychopharmacology 2023年 75卷 S253-S253页

作者： Dinneen, Thomas Molloy, Ciara J. Cliquet, Freddy Leblond, Claire S. Bourgeron, Thomas Cooke, Jennifer Loth, Eva Buitelaar, Jan K. Lopez, Lorna M. Gallagher, Louise Trinity Translational Medicines Institute Trinity College Dublin Human Genetics and Cognitive Functions Unit Institut Pasteur University Paris Diderot Institute of Psychiatry Psychology and Neuroscience King's College London Donders Institute for Brain Cognition and Behaviour Radboud University Karakter Child and Adolescent Psychiatry University Centre Radboud University Medical Center Maynooth University Trinity Translational Medicines Institute Trinity College Dublin The Peter Gilgan Centre for Research and Learning Hospital for Sick Children Centre for Addiction and Mental Health University of Toronto

BackgroundNeurodevelopmental disorders (NDDs) are complex, polygenic conditions which require genome-wide approaches to dissect their genetic architecture. Additionally, family-based approaches can help in understanding the differences in inheritance patterns of NDD-associated loci. Here we use whole-genome sequence data and genome-wide imputed genotype data from 922 individuals from the EU-AIMS Longitudinal European Autism Project (LEAP) cohort to investigate the contributions of both rare and common genetic variants to autism and intellectual disability (ID) outcomes. MethodsPolygenic scores for three NDDs (autism, ADHD, schizophrenia) and two cognitive traits (cognition, educational attainment) were generated using PRSice2. Putatively deleterious SNVs and Indels were filtered using three gene-sets – SFARI (autism-associated loci), DDD (ID associated loci), and brain-expressed, intolerant to loss-of-function loci. CNVs in high-confidence NDD (HC-NDD) loci were also included for analyses. Logistic regression analyses were conducted to assess the relationship between rare and common genetic variation and NDD outcomes. Furthermore, polygenic transmission disequilibrium tests (pTDT) were conducted to assess whether carriers of HC-NDD loci with autism (n= 33) inherit less NDD polygenic risk compared to non-carriers with autism (n= 179). ResultsPolygenic scores for ADHD (P= 2.95e-04; OR= 1.49) and schizophrenia (P = 0.01; OR= 0.76) are associated with NDD outcomes with small local effect size estimates. Interestingly, these results indicate that schizophrenia polygenic score has a potential protective effect against NDD outcomes. HC-NDD CNVs and rare SNVs/Indels were not associated with NDD outcomes. There were no differences observed in polygenic inheritance patterns between carriers of HC-NDD CNVs with autism and non-carriers with autism. DiscussionPolygenic scores for ADHD and schizophrenia contribute to NDD outcomes in the LEAP cohort, highlighting their potential i

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Natural language processing of multi-hospital electronic health records for public health surveillance of suicidality

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npj Mental Health Research 2024年第1期3卷 6页

作者： Bey, Romain Cohen, Ariel Trebossen, Vincent Dura, Basile Geoffroy, Pierre-Alexis Jean, Charline Landman, Benjamin Petit-Jean, Thomas Chatellier, Gilles Sallah, Kankoe Tannier, Xavier Bourmaud, Aurelie Delorme, Richard Innovation and Data unit IT Department Assistance Publique-Hôpitaux de Paris Paris France Child and Adolescent Psychiatry Department Robert Debré University Hospital Assistance Publique-Hôpitaux de Paris Paris France Département de psychiatrie et d’addictologie GHU Paris Nord DMU neurosciences Bichat - Claude Bernard Hospital Assistance Publique-Hôpitaux de Paris Paris 75018 France GHU Paris – psychiatry & neurosciences 1 rue Cabanis Paris 75014 France NeuroDiderot Inserm FHU I2-D2 université Paris Cité Paris 75019 France CNRS UPR 3212 Institute for cellular and integrative neurosciences Strasbourg 67000 France Université Paris-Est Créteil INSERM Créteil IMRB U955 France Service Santé Publique & URC Hôpital Henri Mondor Assistance Publique-Hôpitaux de Paris Créteil France Université Paris Cité Paris France URC PNVS CIC-EC 1425 INSERM Bichat - Claude Bernard Hospital Assistance Publique-Hôpitaux de Paris Paris France Sorbonne Université Inserm Université Sorbonne Paris Nord Laboratoire d’Informatique Médicale et d’Ingénierie des Connaissances pour la e-Santé (LIMICS) Paris France Clinical Epidemiology Unit Robert Debré University Hospital Assistance Publique-Hôpitaux de Paris Paris France CIC 1426 Inserm Paris France Human Genetics and Cognitive Functions Institut Pasteur Paris France

There is an urgent need to monitor the mental health of large populations, especially during crises such as the COVID-19 pandemic, to timely identify the most at-risk subgroups and to design targeted prevention campaigns. We therefore developed and validated surveillance indicators related to suicidality: the monthly number of hospitalisations caused by suicide attempts and the prevalence among them of five known risks factors. They were automatically computed analysing the electronic health records of fifteen university hospitals of the Paris area, France, using natural language processing algorithms based on artificial intelligence. We evaluated the relevance of these indicators conducting a retrospective cohort study. Considering 2,911,920 records contained in a common data warehouse, we tested for changes after the pandemic outbreak in the slope of the monthly number of suicide attempts by conducting an interrupted time-series analysis. We segmented the assessment time in two sub-periods: before (August 1, 2017, to February 29, 2020) and during (March 1, 2020, to June 31, 2022) the COVID-19 pandemic. We detected 14,023 hospitalisations caused by suicide attempts. Their monthly number accelerated after the COVID-19 outbreak with an estimated trend variation reaching 3.7 (95%CI 2.1–5.3), mainly driven by an increase among girls aged 8–17 (trend variation 1.8, 95%CI 1.2–2.5). After the pandemic outbreak, acts of domestic, physical and sexual violence were more often reported (prevalence ratios: 1.3, 95%CI 1.16–1.48;1.3, 95%CI 1.10–1.64 and 1.7, 95%CI 1.48–1.98), fewer patients died (p = 0.007) and stays were shorter (p < 0.001). Our study demonstrates that textual clinical data collected in multiple hospitals can be jointly analysed to compute timely indicators describing mental health conditions of populations. Our findings also highlight the need to better take into account the violence imposed on women, especially at early ages and in the aftermath of the COVID-

关键词： Epidemiology Psychiatric disorders

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Processing of social and monetary rewards in autism spectrum disorders

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The British journal of psychiatry : the journal of mental science 2023年第3期222卷 100-111页

作者： Sarah Baumeister Carolin Moessnang Nico Bast Sarah Hohmann Pascal Aggensteiner Anna Kaiser Julian Tillmann David Goyard Tony Charman Sara Ambrosino Simon Baron-Cohen Christian Beckmann Sven Bölte Thomas Bourgeron Annika Rausch Daisy Crawley Flavio Dell'Acqua Guillaume Dumas Sarah Durston Christine Ecker Dorothea L Floris Vincent Frouin Hannah Hayward Rosemary Holt Mark H Johnson Emily J H Jones Meng-Chuan Lai Michael V Lombardo Luke Mason Bethany Oakley Marianne Oldehinkel Antonio M Persico Antonia San José Cáceres Thomas Wolfers Eva Loth Declan G M Murphy Jan K Buitelaar Heike Tost Andreas Meyer-Lindenberg Tobias Banaschewski Daniel Brandeis Department of Child and Adolescent Psychiatry and Psychotherapy Central Institute of Mental Health Medical Faculty Mannheim University of Heidelberg Mannheim Germany. Department of Psychiatry and Psychotherapy Central Institute of Mental Health University of Heidelberg Mannheim Germany. Department of Child and Adolescent Psychiatry and Psychotherapy Central Institute of Mental Health Medical Faculty Mannheim University of Heidelberg Mannheim Germany and Department of Child and Adolescent Psychiatry Psychosomatics and Psychotherapy University Hospital Frankfurt am Main Goethe University Frankfurt Germany. Department of Psychology Institute of Psychiatry Psychology & Neuroscience King's College London London United Kingdom and Department of Applied Psychology: Health Development Enhancement and Intervention University of Vienna Vienna Austria. Neurospin Centre CEA Saclay Gif sur Yvette France. Department of Psychology Institute of Psychiatry Psychology & Neuroscience King's College London London UK. Department of Psychiatry University Medical Center Utrecht Brain Center Utrecht University Utrecht the Netherlands. Autism Research Centre Department of Psychiatry University of Cambridge UK. Donders Institute for Brain Cognition and Behaviour Radboud University Nijmegen the Netherlands and Department of Cognitive Neuroscience Radboud University Medical Centre Nijmegen the Netherlands. Center of Neurodevelopmental Disorders (KIND) Centre for Psychiatry Research Department of Women's and Children's Health Karolinska Institutet and Child and Adolescent Psychiatry Stockholm Health Care Services Region Stockholm Stockholm Sweden and School of Allied Health University of Western Australia Perth Western Australia. Institut Pasteur Human Genetics and Cognitive Functions Unit Paris France. Department of Forensic and Neurodevelopmental Sciences Institute of Psychiatry Psychology & Neuroscience King's College London London UK. Department of Forensic and Neurodev

BACKGROUND:Reward processing has been proposed to underpin the atypical social feature of autism spectrum disorder (ASD). However, previous neuroimaging studies have yielded inconsistent results regarding the specificity of atypicalities for social reward processing in ASD. AIMS:Utilising a large sample, we aimed to assess reward processing in response to reward type (social, monetary) and reward phase (anticipation, delivery) in ASD. METHOD:Functional magnetic resonance imaging during social and monetary reward anticipation and delivery was performed in 212 individuals with ASD (7.6-30.6 years of age) and 181 typically developing participants (7.6-30.8 years of age). RESULTS:Across social and monetary reward anticipation, whole-brain analyses showed hypoactivation of the right ventral striatum in participants with ASD compared with typically developing participants. Further, region of interest analysis across both reward types yielded ASD-related hypoactivation in both the left and right ventral striatum. Across delivery of social and monetary reward, hyperactivation of the ventral striatum in individuals with ASD did not survive correction for multiple comparisons. Dimensional analyses of autism and attention-deficit hyperactivity disorder (ADHD) scores were not significant. In categorical analyses, comparisons showed that ASD effects were most pronounced in participants with ASD without co-occurring ADHD. CONCLUSIONS:Our results do not support current theories linking atypical social interaction in ASD to specific alterations in social reward processing. Instead, they point towards a generalised hypoactivity of ventral striatum in ASD during anticipation of both social and monetary rewards. We suggest this indicates attenuated reward seeking in ASD independent of social content and that elevated ADHD symptoms may attenuate altered reward seeking in ASD.

关键词： ADHD symptoms Autism spectrum disorder autism traits fMRI multisite reward processing

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P18 - Impact of the COVID-19 pandemic on the hospitalization rates for mental health conditions and self-harm in children and adolescents in metropolitan France

Journal of Epidemiology and Population Health

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Journal of Epidemiology and Population Health 2024年 72卷

作者： Z. Valtuille V. Trebossen N. Ouldali A. Bourmaud C. Gandré C. Aupiais S. Katsahian R. Delorme H. Peyre F. Kaguelidou Robert Debré University Hospital AP-HP Nord Center of Clinical Investigations Inserm CIC1426 Paris France Paris Cité University EA7323 Perinatal and Pediatric Pharmacology and Therapeutic Assessment Paris France Robert Debré University Hospital AP-HP Nord Paris Cité University Department of Child and Adolescent Psychiatry Paris France Robert Debré University Hospital AP-HP Nord Paris Cité University Department of General Pediatrics Pediatric Infectious Disease and Internal Medicine Paris France Robert Debré University Hospital AP-HP Nord UMR-S ECEVE 1123 Paris Cité University Clinical Epidemiology Unit Inserm CIC1426 Paris France Robert Debré University Hospital AP-HP Nord Department of Medical Informatics Paris France Institute for research and information in health economics Irdes Paris France AP-HP Hôpital Jean-Verdier Seine- Saint-Denis UMR-S ECEVE 1123 Paris Cité University Department of Pediatric Emergency Care Paris France AP-HP Hôpital Européen Georges Pompidou Unité de recherche clinique AP-HP Centre Inserm HeKA INRIA Université Paris Cité Paris Centre d'investigation clinique 1418 (CIC1418) Epidémiologie clinique Paris France Institut Pasteur Human Genetics & Cognitive Functions Paris France Montpellier University Hospital MUSE University Autism Reference Centre of Languedoc-Roussillon CRA-LR Excellence Centre for Autism and Neurodevelopmental disorders CeAND Montpellier France CESP Centre de recherche en épidémiologie et santé des populations Inserm U1178 Villejuif France

Background The long-term impact of the COVID-19 pandemic on the mental health of children and adolescents is yet unknown. The aim of this study was to assess the impact of the COVID-19 pandemic on the rates of hospitalizations for mental health (MH) conditions and self-harm (SH) among children and adolescents (aged 6 to 17) in metropolitan France three years after the pandemic onset. Methods This is a national cohort study based on hospital medico-administrative data (PMSI) collected in the pre-pandemic onset period (Jan. 2016 - Feb. 2020), initial pandemic period (March 2020 - May 2020), 1st post-pandemic year (June 2020 - May 2021), 2nd post-pandemic year (June 2021 - May 2022), and 3rd post-pandemic year (June 2022 - May 2023). Monthly hospitalization rates per 100,000 children and adolescents were modeled using a time-series analysis to assess changes in monthly rates and temporal trends and to calculate cumulative percent differences between estimated and expected hospitalization rates in each post-pandemic period. The analysis was stratified by age and sex groups (children/adolescents; boys/girls), and by specific MH diagnosis. Results A total of 583,244 hospitalizations (18.6% children and 81.4% adolescents) were analyzed: 81.4% were related to a MH condition and 18.6% were related to intentional SH. Before the pandemic onset. increasing trends were observed only for SH hospitalizations During the initial pandemic period, all rates immediately decreased. Trends of hospital admissions for MH conditions increased during the first post-pandemic year and decreased thereafter. Trends for SH admissions increased in the first two post-pandemic years, and decreased in the third. Overall, in the 1st post-pandemic year, the rate of hospital admissions for MH decreased by 3% [-6.9%; 0.8%], and increased for SH by 8% [-1.5%; 17.9%] compared to the expected rates. During the 2nd post-pandemic year, cumulative percent increases were observed for both MH and SH hospitalizat

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P17 - Impact of the COVID-19 pandemic on the rates of emergency department visits for mental health conditions and self-harm in children and adolescents in metropolitan France

Journal of Epidemiology and Population Health

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Journal of Epidemiology and Population Health 2024年 72卷

作者： Z. Valtuille V. Trebossen N. Ouldali A. Bourmaud C. Gandré C. Aupiais S. Katsahian R. Delorme H. Peyre F. Kaguelidou Robert Debré University Hospital AP-HP Nord Center of Clinical Investigations Inserm CIC1426 Paris France Paris Cité University EA7323 Perinatal and Pediatric Pharmacology and Therapeutic Assessment Paris France Robert Debré University Hospital AP-HP Nord Paris Cité University Department of Child and Adolescent Psychiatry Paris France Robert Debré University Hospital AP-HP Nord Paris Cité University Department of General Pediatrics Pediatric Infectious Disease and Internal Medicine Paris France Robert Debré University Hospital AP-HP Nord UMR-S ECEVE 1123 Paris Cité University Clinical Epidemiology Unit Inserm CIC1426 Paris France Robert Debré University Hospital AP-HP Nord Department of Medical Informatics Paris France Institute for research and information in health economics Irdes Paris France AP-HP Hôpital Jean-Verdier Seine- Saint-Denis UMR-S ECEVE 1123 Paris Cité University Department of Pediatric Emergency Care Paris France AP-HP Hôpital Européen Georges Pompidou Unité de recherche clinique AP-HP Centre Inserm HeKA INRIA Universite Paris Cité Centre d'investigation clinique 1418 (CIC1418) Epidémiologie clinique Paris France Institut Pasteur Human Genetics & Cognitive Functions Paris France Montpellier University Hospital MUSE University Autism Reference Centre of Languedoc-Roussillon CRA-LR Excellence Centre for Autism and Neurodevelopmental disorders CeAND Montpellier France Université Paris-Saclay UVSQ Inserm U1178 Centre de recherche en épidémiologie et santé des population Team DevPsy Villejuif France

Background The long-term impact of the COVID-19 pandemic on the mental health of children and adolescents is yet unknown. We aimed to assess the impact of the COVID-19 pandemic on the rate of emergency department (ED) visits for mental health (MH) conditions and self-harm (SH) among children and adolescents (aged 6 to 17 years) in metropolitan France three years after the pandemic onset. Methods This is a national cohort study based on hospital medico-administrative data (PMSI – RPU database) collected in the pre-pandemic onset period (Jan. 2016 - Feb. 2020), initial pandemic period (March 2020 - May 2020), 1st post-pandemic year (June 2020 - May 2021), 2nd post-pandemic year (June 2021 - May 2022), and 3rd post-pandemic year (June 2022 - May 2023). Monthly rates of ED visits per 100,000 children and adolescents were modeled using a time-series analysis to assess changes in monthly rates and temporal trends and to calculate cumulative percent differences between estimated and expected ED visits rates in each post-pandemic period. The analysis was stratified by age and sex groups (children/adolescents; boys/girls), and by specific MH diagnosis. Results A total of 432,725 ED visits were analyzed (13.8% children and 86.2% adolescents): 79.9% were related to a mental health condition and 20.1% related to intentional self-harm. Increasing trends were observed in ED visits for both MH conditions and SH before the pandemic onset. In the initial pandemic period, rates immediately and significantly dropped. Trends of ED visits for MH conditions increased during the first post-pandemic year only, whereas trends for SH visits increased in the first two post-pandemic years, and decreased thereafter. Overall, in the 1st post-pandemic year, the rate of ED visits for MH conditions decreased by 6.1% [-10.3%; -1.9%] and the rate of visits for SH increased by 10% [1%; 18.9%] compared to the expected rates. During the 2nd post-pandemic year, increases were observed in ED visits for bo

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Author Correction: A framework to identify contributing genes in patients with Phelan-McDermid syndrome

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npj Genomic Medicine 2019年第1期4卷 1页

作者： Anne-Claude Tabet Thomas Rolland Marie Ducloy Jonathan Lévy Julien Buratti Alexandre Mathieu Damien Haye Laurence Perrin Céline Dupont Sandrine Passemard Yline Capri Alain Verloes Séverine Drunat Boris Keren Cyril Mignot Isabelle Marey Aurélia Jacquette Sandra Whalen Eva Pipiras Brigitte Benzacken Sandra Chantot-Bastaraud Alexandra Afenjar Delphine Héron Cédric Le Caignec Claire Beneteau Olivier Pichon Bertrand Isidor Albert David Laila El Khattabi Stephan Kemeny Laetitia Gouas Philippe Vago Anne-Laure Mosca-Boidron Laurence Faivre Chantal Missirian Nicole Philip Damien Sanlaville Patrick Edery Véronique Satre Charles Coutton Françoise Devillard Klaus Dieterich Marie-Laure Vuillaume Caroline Rooryck Didier Lacombe Lucile Pinson Vincent Gatinois Jacques Puechberty Jean Chiesa James Lespinasse Christèle Dubourg Chloé Quelin Mélanie Fradin Hubert Journel Annick Toutain Dominique Martin Abdelamdjid Benmansour Claire S. Leblond Roberto Toro Frédérique Amsellem Richard Delorme Thomas Bourgeron Genetics Department Robert Debré Hospital APHP Paris France Human Genetics and Cognitive Functions Institut Pasteur Paris France CNRS UMR 3571 Genes Synapses and Cognition Institut Pasteur Paris France Sorbonne Paris Cité Human Genetics and Cognitive Functions Université Paris Diderot Paris France Cytogenetics Unit Pitié Salpetrière Hospital APHP Paris France Neurogenetics Unit Pitié Salpetrière Hospital APHP Paris France Clinical Genetics Unit Pitié Salpetrière Hospital APHP Paris France Cytogenetics Unit Jean Verdier Hospital APHP Bondy France Cytogenetics Unit Trousseau Hospital APHP Paris France Clinical Genetics Unit Trousseau Hospital APHP Paris France Clinical Genetics Unit Nantes Hospital Nantes France Cytogenetics Unit Cochin Hospital APHP Paris France Genetics Unit CHU Estaing Clermont-Ferrand France Cytogenetics Unit Dijon Hospital Dijon France Clinical Genetics Unit Dijon Hospital Dijon France Genetics Unit La Timone Hospital Marseille France Cytogenetics Unit Lyon Civil Hospital Lyon France Clinical Genetics Unit Lyon Civil Hospital Lyon France Cytogenetics Unit Grenoble Hospital Grenoble France Clinical Genetics Unit Grenoble Hospital Grenoble France Genetics Unit Bordeaux Hospital Bordeaux France Genetics Unit Montpellier Hospital Montpellier France Genetics Unit CHRU Nimes Nimes France Cytogenetics Unit Chambéry-Hôtel-Dieu Hospital Chambéry France Genetics Unit CHU Rennes Rennes France Genetics Unit Chubert Hospital Vannes France Genetics Unit Bretonneau Hospital Tours France Genetics Unit CH Le Mans Le Mans France Department of Child and Adolescent Psychiatry Robert Debré Hospital APHP Paris France

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Corrigendum: Polygenic Architecture of human Neuroanatomical Diversity

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Cerebral cortex (New York, N.Y. : 1991) 2020年第5期30卷 3435-3436页

作者： Anne Biton Nicolas Traut Jean-Baptiste Poline Benjamin S Aribisala Mark E Bastin Robin Bülow Simon R Cox Ian J Deary Masaki Fukunaga Hans J Grabe Saskia Hagenaars Ryota Hashimoto Masataka Kikuchi Susana Muñoz Maniega Matthias Nauck Natalie A Royle Alexander Teumer Maria Valdés Hernández Uwe Völker Joanna M Wardlaw Katharina Wittfeld Hidenaga Yamamori Thomas Bourgeron Roberto Toro Human Genetics and Cognitive Functions Unit Institut Pasteur UMR 3571 CNRS Université Paris Diderot Paris 75015 France. Hub de Bioinformatique et Biostatistique-Département Biologie Computationnelle Institut Pasteur USR 3756 CNRS Paris 75015 France. Department of Neurology and Neurosurgery Montreal Neurological Institute McGill University Montreal Quebec H3A 2B4 Canada. Centre for Cognitive Ageing and Cognitive Epidemiology Department of Psychology University of Edinburgh Edinburgh EH8 9JZ UK. Centre for Clinical Brain Sciences University of Edinburgh Edinburgh EH16 4SB UK. Department of Computer Science Lagos State University Lagos 102101 Nigeria. Brain Research Imaging Centre Centre for Clinical Brain Sciences University of Edinburgh Edinburgh EH16 4TJ UK. The Institute of Diagnostic Radiology and Neuroradiology University Medicine Greifswald Greifswald 17489 Germany. Department of Psychology University of Edinburgh Edinburgh EH8 9JZ UK. Division of Cerebral Integration National Institute for Physiological Sciences Okazaki 444-8585 Japan. Department of Physiological Sciences School of Life Sciences The Graduate University for Advanced Studies (SOKENDAI) Hayama 240-0193 Japan. Department of Psychiatry and Psychotherapy University Medicine Greifswald Greifswald 17485 Germany. German Centre of Neurodegenerative Diseases (DZNE) Site Greifswald/Rostock Greifswald 17489 Germany. The Social Genetic and Developmental Psychiatry Research Centre Institute of Psychiatry Psychology & Neuroscience King's College London London SE5 8AF UK. Department of Pathology of Mental Diseases National Institute of Mental Health National Center of Neurology and Psychiatry Tokyo 187-0031 Japan. Department of Genome Informatics Graduate School of Medicine Osaka University Osaka 565-0871 Japan. Institute of Clinical Chemistry and Laboratory Medicine University Medicine Greifswald Greifswald 17475 Germany. DZHK (German Centre for Cardiovascular Research) Partner Si

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LifeTime and improving European healthcare through cell-based interceptive medicine (vol 587, pg 377, 2020)

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NATURE 2021年第7852期592卷 E8-E8页

作者： Rajewsky, Nikolaus Almouzni, Genevieve Gorski, Stanislaw A. Aerts, Stein Amit, Ido Bertero, Michela G. Bock, Christoph Bredenoord, Annelien L. Cavalli, Giacomo Chiocca, Susanna Clevers, Hans De Strooper, Bart Eggert, Angelika Ellenberg, Jan Fernandez, Xose M. Figlerowicz, Marek Gasser, Susan M. Hubner, Norbert Kjems, Jorgen Knoblich, Jurgen A. Krabbe, Grietje Lichter, Peter Linnarsson, Sten Marine, Jean-Christophe Marioni, John C. Marti-Renom, Marc A. Netea, Mihai G. Nickel, Dorthe Nollmann, Marcelo Novak, Halina R. Parkinson, Helen Piccolo, Stefano Pinheiro, Ines Pombo, Ana Popp, Christian Reik, Wolf Roman-Roman, Sergio Rosenstiel, Philip Schultze, Joachim L. Stegle, Oliver Tanay, Amos Testa, Giuseppe Thanos, Dimitris Theis, Fabian J. Torres-Padilla, Maria-Elena Valencia, Alfonso Vallot, Celine van Oudenaarden, Alexander Vidal, Marie Voet, Thierry Berlin Institute for Medical Systems Biology Max Delbrück Center for Molecular Medicine in the Helmholtz Association Berlin Germany Charité-Universitätsmedizin Berlin Germany Berlin Institute of Health (BIH) Berlin Germany German Center for Cardiovascular Research (DZHK) Partner Site Berlin Berlin Germany Institute for Biology Humboldt University of Berlin Berlin Germany Cardiovascular and Metabolic Sciences Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) Berlin Germany Department of Pediatric Oncology/Hematology Charité-Universitätsmedizin Berlin Berlin Germany Institut Curie CNRS PSL Research University Sorbonne Université Nuclear Dynamics Unit Equipe Labellisée Ligue contre le cancer Paris France VIB Center for Brain and Disease Research Leuven Belgium Department of Human Genetics KU Leuven Leuven Belgium Department of Neurosciences KU Leuven Leuven Belgium UK Dementia Research Institute at UCL University College London London UK Wellcome Sanger Institute Wellcome Genome Campus Cambridge UK Department of Immunology Weizmann Institute of Science Rehovot Israel Centre for Genomic Regulation (CRG) Barcelona Institute of Science and Technology Barcelona Spain CNAG-CRG Centre for Genomic Regulation Barcelona Institute of Science and Technology Barcelona Spain Universitat Pompeu Fabra Barcelona Spain ICREA Barcelona Spain CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences Vienna Austria Department of Laboratory Medicine Medical University of Vienna Vienna Austria Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases Vienna Austria Department of Medical Humanities Julius Center for Health Sciences and Primary Care University Medical Center Utrecht Utrecht The Netherlands Institute of Human Genetics UMR 9002 CNRS and University of Montpellier Montpellier France Department of Experimental Oncology IEO European Institute of Oncology IRCCS Milan Italy Department of Oncology and Hemato

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